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Articles 31 - 54 of 54
Full-Text Articles in Entire DC Network
Space Radiation: The Number One Risk To Astronaut Health Beyond Low Earth Orbit, Jeffery C. Chancellor, Graham B.I. Scott, Jeffrey P. Sutton
Space Radiation: The Number One Risk To Astronaut Health Beyond Low Earth Orbit, Jeffery C. Chancellor, Graham B.I. Scott, Jeffrey P. Sutton
Faculty Publications
Projecting a vision for space radiobiological research necessitates understanding the nature of the space radiation environment and how radiation risks influence mission planning, timelines and operational decisions. Exposure to space radiation increases the risks of astronauts developing cancer, experiencing central nervous system (CNS) decrements, exhibiting degenerative tissue effects or developing acute radiation syndrome. One or more of these deleterious health effects could develop during future multi-year space exploration missions beyond low Earth orbit (LEO). Shielding is an effective countermeasure against solar particle events (SPEs), but is ineffective in protecting crew members from the biological impacts of fast moving, highly-charged galactic …
Investigating The Effect Of Insurance Fraud On Mouse Usage In Human-Computer Interactions, Martin Hibbeln, Jeffrey L. Jenkins, Christoph Schneider, Joseph S. Valacich, Markus Weinmann
Investigating The Effect Of Insurance Fraud On Mouse Usage In Human-Computer Interactions, Martin Hibbeln, Jeffrey L. Jenkins, Christoph Schneider, Joseph S. Valacich, Markus Weinmann
Faculty Publications
The completion of online forms is the catalyst for many business and governmental processes. However, providing fraudulent information in such forms is pervasive, resulting in costly consequences for organizations and society. Furthermore, detecting fraudulent responses in online forms is often very difficult, time consuming, and expensive. This research proposes that analyzing users’ mouse movements may reveal when a person is being fraudulent. Namely, based on neuroscience and deception theory, the paper explains how deception may influence hand movements captured via the computer mouse. In an insurance fraud context, a study is conducted to explore these proposed relationships. The results suggest …
Exploring Post-Translational Arginine Modification Using Chemically Synthesized Methylglyoxal Hydroimidazolones, Tina Wang, Rendy Kartika, David A. Spiegel
Exploring Post-Translational Arginine Modification Using Chemically Synthesized Methylglyoxal Hydroimidazolones, Tina Wang, Rendy Kartika, David A. Spiegel
Faculty Publications
The methylglyoxal-derived hydroimidazolones (MG-Hs) comprise the most prevalent class of non-enzymatic, post-translational modifications of protein arginine residues found in nature. These adducts form spontaneously in the human body, and are also present at high levels in the human diet. Despite numerous lines of evidence suggesting that MG-H-arginine adducts play critical roles in both healthy and disease physiology in humans, detailed studies of these molecules have been hindered by a lack of general synthetic strategies for their preparation in chemically homogeneous form, and on scales sufficient to enable detailed biochemical and cellular investigations. To address this limitation, we have developed efficient, …
Report And Reflections From Year One Of The Nsf Gk- 12 Program At Usm, Sherry S. Herron, J. Hanna, K. Wingo
Report And Reflections From Year One Of The Nsf Gk- 12 Program At Usm, Sherry S. Herron, J. Hanna, K. Wingo
Faculty Publications
No abstract provided.
Pharmacokinetic Pilot Study Of The Antiangiogenic Activity Of Standardized Platycodi Radix, Emma M. Twiner, Zhijun Liu, Jeffrey Gimble, Ying Yu, Frank Greenway
Pharmacokinetic Pilot Study Of The Antiangiogenic Activity Of Standardized Platycodi Radix, Emma M. Twiner, Zhijun Liu, Jeffrey Gimble, Ying Yu, Frank Greenway
Faculty Publications
Introduction: Platycodi radix is a radish used in food, such as Korean kimchi, and has been shown to cause weight loss in rodents. Platycodin D is considered its active ingredient and has been shown to inhibit lipases. The authors hypothesized that platycodi radix and the platycodin D it contains inhibit angiogenesis; another mechanism for weight loss. Methods: This study tested platycodi radix extract, platycodin D, and an extract of platycodi radix standardized to platycodin D for their ability to inhibit angiogenesis in a human adipose tissue assay. This study treated five healthy volunteers, orally, with platycodi radix extract standardized to …
The Nlrp3 Inflammasome Instigates Obesity-Induced Inflammation And Insulin Resistance, Bolormaa Vandanmagsar, Yun Hee Youm, Anthony Ravussin, Jose E. Galgani, Krisztian Stadler, Randall L. Mynatt, Eric Ravussin, Jacqueline M. Stephens, Vishwa Deep Dixit
The Nlrp3 Inflammasome Instigates Obesity-Induced Inflammation And Insulin Resistance, Bolormaa Vandanmagsar, Yun Hee Youm, Anthony Ravussin, Jose E. Galgani, Krisztian Stadler, Randall L. Mynatt, Eric Ravussin, Jacqueline M. Stephens, Vishwa Deep Dixit
Faculty Publications
The emergence of chronic inflammation during obesity in the absence of overt infection or well-defined autoimmune processes is a puzzling phenomenon. The Nod-like receptor (NLR) family of innate immune cell sensors, such as the nucleotide-binding domain, leucine-rich-containing family, pyrin domain-containing-3 (Nlrp3, but also known as Nalp3 or cryopyrin) inflammasome are implicated in recognizing certain nonmicrobial originated 'danger signals' leading to caspase-1 activation and subsequent interleukin-1β 2 (IL-1β 2) and IL-18 secretion. We show that calorie restriction and exercise-mediated weight loss in obese individuals with type 2 diabetes is associated with a reduction in adipose tissue expression of Nlrp3 as well …
Automatic Generation Of Music For Inducing Emotive Response, Tony R. Martinez, Kristine Monteith, Dan A. Ventura
Automatic Generation Of Music For Inducing Emotive Response, Tony R. Martinez, Kristine Monteith, Dan A. Ventura
Faculty Publications
We present a system that generates original music designed to match a target emotion. It creates n-gram models, Hidden Markov Models, and other statistical distributions based on musical selections from a corpus representing a given emotion and uses these models to probabilistically generate new musical selections with similar emotional content. This system produces unique and often remarkably musical selections that tend to match a target emotion, performing this task at a level that approaches human competency for the same task.
Creation Care And The Christian, Jo Ann Davidson
Creation Care And The Christian, Jo Ann Davidson
Faculty Publications
No abstract provided.
How Can A Video Game Cause Panic Attacks? 1. Effects Of An Auditory Stressor On The Human Brainstem, Judith Lauter, Elizabeth Mathukutty, Brandon Scott
How Can A Video Game Cause Panic Attacks? 1. Effects Of An Auditory Stressor On The Human Brainstem, Judith Lauter, Elizabeth Mathukutty, Brandon Scott
Faculty Publications
The auditory brainstem response (ABR) was recorded during simultaneous binaural presentation of two types of sounds: 1) condensation clicks presented through in-the-ear earphones at 43.1/sec, 60dB nHL; and 2) recordings of breathing sounds, presented through supra-aural headphones, at levels adjusted by participants to be equivalent to the clicks. In alternate blocks, the breathing sounds were either: 1) a recording of quiet breathing (blocks 1, 3, 5); or 2) a recording of erratic (stressed) breathing (blocks 2, 4). The erratic breathing was modeled on a video game soundtrack in which the character was represented as running, wounded, and frightened. Four 2048-sweep …
Modeling The Daily Activities Of Breeding Colonial Seabirds: Dynamic Occupancy Patterns In Multiple Habitat Patches, Andrea L. Moore, Smruti P. Damania, Shandelle M. Henson, James L. Hayward
Modeling The Daily Activities Of Breeding Colonial Seabirds: Dynamic Occupancy Patterns In Multiple Habitat Patches, Andrea L. Moore, Smruti P. Damania, Shandelle M. Henson, James L. Hayward
Faculty Publications
We constructed differential equation models for the diurnal abundance and distribution of breeding glaucous-winged gulls (Larus glaucescens) as they moved among nesting and non-nesting habitat patches. We used time scale techniques to reduce the differential equations to algebraic equations and connected the models to field data. The models explained the data as a function of abiotic environmental variables with R2=0.57. A primary goal of this study is to demonstrate the utility of a methodology that can be used by ecologists and wildlife managers to understand and predict daily activity patterns in breeding seabirds.
Genome Analysis Of The Platypus Reveals Unique Signatures Of Evolution, Wesley C. Warren, La Deana W. Hillier, Jennifer A. Marshall Graves, Ewan Birney, Chris P. Ponting, Frank Grützner, Katherine Belov, Webb Miller, Laura Clarke, Asif T. Chinwalla, Shiaw Pyng Yang, Andreas Heger, Devin P. Locke, Pat Miethke, Paul D. Waters, Frédéric Veyrunes, Lucinda Fulton, Bob Fulton, Tina Graves, John Wallis, Xose S. Puente, Carlos López-Otín, Gonzalo R. Ordóñez, Evan E. Eichler, Lin Chen, Ze Cheng, Janine E. Deakin, Amber Alsop, Katherine Thompson, Patrick Kirby, Anthony T. Papenfuss, Matthew J. Wakefield, Tsviya Olender, Doron Lancet
Genome Analysis Of The Platypus Reveals Unique Signatures Of Evolution, Wesley C. Warren, La Deana W. Hillier, Jennifer A. Marshall Graves, Ewan Birney, Chris P. Ponting, Frank Grützner, Katherine Belov, Webb Miller, Laura Clarke, Asif T. Chinwalla, Shiaw Pyng Yang, Andreas Heger, Devin P. Locke, Pat Miethke, Paul D. Waters, Frédéric Veyrunes, Lucinda Fulton, Bob Fulton, Tina Graves, John Wallis, Xose S. Puente, Carlos López-Otín, Gonzalo R. Ordóñez, Evan E. Eichler, Lin Chen, Ze Cheng, Janine E. Deakin, Amber Alsop, Katherine Thompson, Patrick Kirby, Anthony T. Papenfuss, Matthew J. Wakefield, Tsviya Olender, Doron Lancet
Faculty Publications
We present a draft genome sequence of the platypus, Ornithorhynchus anatinus. This monotreme exhibits a fascinating combination of reptilian and mammalian characters. For example, platypuses have a coat of fur adapted to an aquatic lifestyle; platypus females lactate, yet lay eggs; and males are equipped with venom similar to that of reptiles. Analysis of the first monotreme genome aligned these features with genetic innovations. We find that reptile and platypus venom proteins have been co-opted independently from the same gene families; milk protein genes are conserved despite platypuses laying eggs; and immune gene family expansions are directly related to platypus …
Promoting Self-Confidence In Clinical Nursing Students, Karen M. Lundberg
Promoting Self-Confidence In Clinical Nursing Students, Karen M. Lundberg
Faculty Publications
Clinical nursing instructors are continually telling their students that they just need more confidence. But how do students find this needed confidence and how can nursing instructors help them? The author discusses sources and principles of confidence in relationship to teaching behaviors and strategies for increasing self-confidence, such as simulations, peer modeling, story telling, skill review sessions, and journaling.
Ellen White’S Interpretation And Use Of The Seven Letters Of Revelation, Denis Fortin
Ellen White’S Interpretation And Use Of The Seven Letters Of Revelation, Denis Fortin
Faculty Publications
No abstract provided.
Those Pesky Footnotes - Part I, Douglas E. Abrams
Those Pesky Footnotes - Part I, Douglas E. Abrams
Faculty Publications
No abstract provided.
Mobile Dna In Old World Monkeys: A Glimpse Through The Rhesus Macaque Genome, Kyudong Han, Miriam K. Konkel, Jinchuan Xing, Hui Wang, Jungnam Lee, Thomas J. Meyer, Charles T. Huang, Erin Sandifer, Kristi Hebert, Erin W. Barnes, Robert Hubley, Webb Miller, Arian F.A. Smit, Brygg Ullmer, Mark A. Batzer
Mobile Dna In Old World Monkeys: A Glimpse Through The Rhesus Macaque Genome, Kyudong Han, Miriam K. Konkel, Jinchuan Xing, Hui Wang, Jungnam Lee, Thomas J. Meyer, Charles T. Huang, Erin Sandifer, Kristi Hebert, Erin W. Barnes, Robert Hubley, Webb Miller, Arian F.A. Smit, Brygg Ullmer, Mark A. Batzer
Faculty Publications
The completion of the draft sequence of the rhesus macaque genome allowed us to study the genomic composition and evolution of transposable elements in this representative of the Old World monkey lineage, a group of diverse primates closely related to humans. The L1 family of long interspersed elements appears to have evolved as a single lineage, and Alu elements have evolved into four currently active lineages. We also found evidence of elevated horizontal transmissions of retroviruses and the absence of DNA transposon activity in the Old World monkey lineage. In addition, ∼100 precursors of composite SVA (short interspersed element, variable …
Evolutionary And Biomedical Insights From The Rhesus Macaque Genome, Richard A. Gibbs, Jeffrey Rogers, Michael G. Katze, Roger Bumgarner, George M. Weinstock, Elaine R. Mardis, Karin A. Remington, Robert L. Strausberg, J. Craig Venter, Richard K. Wilson, Mark A. Batzer, Carlos D. Bustamante, Evan E. Eichler, Matthew W. Hahn, Ross C. Hardison, Kateryna D. Makova, Webb Miller, Aleksandar Milosavljevic, Robert E. Palermo, Adam Siepel, James M. Sikela, Tony Attaway, Stephanie Bell, Kelly E. Bernard, Christian J. Buhay, Mimi N. Chandrabose, Marvin Dao, Clay Davis, Kimberly D. Delehaunty, Yan Ding, Huyen H. Dinh, Shannon Dugan-Rocha, Lucinda A. Fulton, Ramatu Ayiesha Gabisi
Evolutionary And Biomedical Insights From The Rhesus Macaque Genome, Richard A. Gibbs, Jeffrey Rogers, Michael G. Katze, Roger Bumgarner, George M. Weinstock, Elaine R. Mardis, Karin A. Remington, Robert L. Strausberg, J. Craig Venter, Richard K. Wilson, Mark A. Batzer, Carlos D. Bustamante, Evan E. Eichler, Matthew W. Hahn, Ross C. Hardison, Kateryna D. Makova, Webb Miller, Aleksandar Milosavljevic, Robert E. Palermo, Adam Siepel, James M. Sikela, Tony Attaway, Stephanie Bell, Kelly E. Bernard, Christian J. Buhay, Mimi N. Chandrabose, Marvin Dao, Clay Davis, Kimberly D. Delehaunty, Yan Ding, Huyen H. Dinh, Shannon Dugan-Rocha, Lucinda A. Fulton, Ramatu Ayiesha Gabisi
Faculty Publications
The rhesus macaque (Macaca mulatta) is an abundant primate species that diverged from the ancestors of Homo sapiens about 25 million years ago. Because they are genetically and physiologically similar to humans, rhesus monkeys are the most widely used nonhuman primate in basic and applied biomedical research. We determined the genome sequence of an Indian-origin Macaca mulatta female and compared the data with chimpanzees and humans to reveal the structure of ancestral primate genomes and to identify evidence for positive selection and lineage-specific expansions and contractions of gene families. A comparison of sequences from individual animals was used to investigate …
Generation And Characterization Of Rabbit Embryonic Stem Cells, Shufen Wang, Xianghui Tang, Yuyu Niu, Hongwei Chen, Bin Li, Tianqing Li, Xiuzhen Zhang, Zhixin Hu, Qi Zhou, Weizhi Ji
Generation And Characterization Of Rabbit Embryonic Stem Cells, Shufen Wang, Xianghui Tang, Yuyu Niu, Hongwei Chen, Bin Li, Tianqing Li, Xiuzhen Zhang, Zhixin Hu, Qi Zhou, Weizhi Ji
Faculty Publications
We described the derivation of four stable pluripotent rabbit embryonic stem cell (ESC) lines, one (RF) from blastocysts fertilized in vivo and cultured in vitro and three (RP01, RP02, and RP03) from parthenogenetic blastocysts. These ESC lines have been cultivated for extended periods (RF >1 year, RP01 >8 months, RP02 >8 months, and RP03 >6 months) in vitro while maintaining expression of pluripotent ESC markers and a normal XY or XX karyotype. The ESCs from all lines expressed alkaline phosphatase, transcription factor Oct-4, stage-specific embryonic antigens (SSEA-1, SSEA-3, and SSEA-4), and the tumor-related antigens (TRA-1-60 and TRA-1-81). Similar to human …
A Chemomechanical Polymer That Functions In Blood Plasma With High Glucose Selectivity, George K. Samoei, Weihua Wang, Jorge O. Escobedo, Xiangyang Xu, Hans Jörg Schneider, Robert L. Cook, Robert M. Strongin
A Chemomechanical Polymer That Functions In Blood Plasma With High Glucose Selectivity, George K. Samoei, Weihua Wang, Jorge O. Escobedo, Xiangyang Xu, Hans Jörg Schneider, Robert L. Cook, Robert M. Strongin
Faculty Publications
(Figure Presented) See the shrink: Systematic modification of poly(methyl methacrylate) leads to a chemomechanical polymer that selectively contracts in the presence of glucose at physiological levels in human blood plasma. The polymer also exhibits good reversibility allowing continuous expansion-contraction cycles. © 2006 Wiley-VCH Verlag GmbH & Co. KGaA.
A Meta-Analysis Of Genome-Wide Linkage Scans For Hypertension: The National Heart, Lung And Blood Institute Family Blood Pressure Program, Michael A. Province, Sharon L.R. Kardia, Koustubh Ranade, Dabeeru C. Rao, Bonnie A. Thiel, Richard S. Cooper, Neil Risch, Stephen T. Turner, David R. Cox, Steven C. Hunt, Alan B. Weder, Eric Boerwinkle
A Meta-Analysis Of Genome-Wide Linkage Scans For Hypertension: The National Heart, Lung And Blood Institute Family Blood Pressure Program, Michael A. Province, Sharon L.R. Kardia, Koustubh Ranade, Dabeeru C. Rao, Bonnie A. Thiel, Richard S. Cooper, Neil Risch, Stephen T. Turner, David R. Cox, Steven C. Hunt, Alan B. Weder, Eric Boerwinkle
Faculty Publications
Background: Four multicenter Networks (GenNet, GENOA, HyperGEN, SAPPHIRe) form the National Heart, Lung and Blood Institute Family Blood Pressure Program (FBPP), to search for hypertension/blood pressure (BP) genes. The networks used different family designs and targeted multiple ethnic groups, using standardized protocols and definitions. Linkage genome scans were done on samples within each network (N = 6245 relatives). Methods: The evidence was synthesized using meta-analysis. Results: Combining ethnic groups, no region reached LOD >2, but several small peaks were identified, including chromosome 2p where two other recent reports find hypertension linkage. Conclusions: No regions show uniformly large effects on BP/hypertension …
An Equity Paradigm For Preventing Genetic Discrimination, Anita Silvers, Michael Ashley Stein
An Equity Paradigm For Preventing Genetic Discrimination, Anita Silvers, Michael Ashley Stein
Faculty Publications
No abstract provided.
Review Of Religion And The Enlightenment: From Descartes To Kant, By James M. Byrne, Denis Fortin
Review Of Religion And The Enlightenment: From Descartes To Kant, By James M. Byrne, Denis Fortin
Faculty Publications
No abstract provided.
Race, Religion, And Cultural Identity: Reconciling The Jurisprudence Of Race And Religion, Tseming Yang
Race, Religion, And Cultural Identity: Reconciling The Jurisprudence Of Race And Religion, Tseming Yang
Faculty Publications
No abstract provided.
Sensory Interaction And Descriptions Of Fabric Hand., L. D. Burns, J. Chandler, D. M. Brown, B. Cameron, M. J. Dallas
Sensory Interaction And Descriptions Of Fabric Hand., L. D. Burns, J. Chandler, D. M. Brown, B. Cameron, M. J. Dallas
Faculty Publications
82 subjects who viewed and felt fabrics (sensory interaction group) used different categories of terms to describe fabric hand than did 38 subjects who only felt the fabrics. Therefore, the methods used to measure fabric hand that isolate the senses may not accurately assess the way in which subjects describe fabric hand in nonlaboratory settings.
Endogenous Retinoids In Rat Epididymal Tissue And Rat And Human Spermatozoa, R. S. Pappas, M. E. Newcomer, D. E. Ong
Endogenous Retinoids In Rat Epididymal Tissue And Rat And Human Spermatozoa, R. S. Pappas, M. E. Newcomer, D. E. Ong
Faculty Publications
Recent work has demonstrated high levels of retinoid binding proteins in rat epididymis, and a lumenal retinoic acid binding protein has been purified. These findings suggested that vitamin A may be involved in spermatozoal maturation in the epididymis. We further addressed this question by quantifying retinol, retinyl esters, and retinoic acid isomers from perfused epididymal tissue, from rat testicular and epididymal spermatozoa, and from human ejaculate sperm. HPLC showed vitamin A levels to be higher in caput than in corpus or cauda tissue. Retinoic acid and 9-cis-retinoic acid were found to be graded from lowest levels in caput to highest …