Digital Commons Network^™

Redressing All Erisa Fiduciary Breaches Under Section 409 (A), Eric D. Chason

Faculty Publications

No abstract provided.

Immature Citizens And The State, Vivian E. Hamilton

Faculty Publications

Citizens are born, but they are also made. How its citizens come to be—whether the educations they receive will expand or constrain their future options, whether the values they assimilate will encourage or dissuade their civic engagement, etc.—fundamentally concerns the state. Through the power it wields over a vast range of policymaking contexts, the state can significantly influence (or designate those who will influence) many of the formative experiences of young citizens. Young citizens’ accumulated experiences in turn can significantly influence the future mature citizens they will become. The state insufficiently considers the cumulative nature of its citizens’ development, however. …

Monitoring Carboplatin Ototoxicity With Distortion-Product Otoacoustic Emissions In Children With Retinoblastoma, Shaum Bhagat, Johnnie Bass, Stephanie White, Ibrahim Qaddoumi, Matthew Wilson, Jianrong Wu, Carlos Rodriguez-Galindo

Faculty Publications

ObjectiveCarboplatin is a common chemotherapy agent with potential ototoxic side effects that is used to treat a variety of pediatric cancers, including retinoblastoma. Retinoblastoma is a malignant tumor of the retina that is usually diagnosed in young children. Distortion-product otoacoustic emission tests offer an effective method of monitoring for ototoxicity in young children. This study was designed to compare measurements of distortion-product otoacoustic emissions obtained before and after several courses of carboplatin chemotherapy in order to examine if (a) mean distortion-product otoacoustic emission levels were significantly different; and (b) if criterion reductions in distortion-product otoacoustic emission levels were observed in …

Critical Theory, Libraries And Culture, Jenny Bossaller, Denice Adkins, Kim M. Thompson

Faculty Publications

There are disparate notions among people within the broad field of information and library science regarding exactly what comprises information science. One broad definition is provided by Tefko Saracevic: “Information science is a field of professional practice and scientific inquiry addressing the problem of effective communication of knowledge records – ʻliteratureʼ – among humans in the context of social, organizational, and individual need for and use of information” (1055- 1056). At its most basic, it seems that information science could be a neutral science if, indeed, it studies everything that is communicated, in any form. However, as noted in the …

Erisa Preemption Doctrine As Health Policy, Joshua P. Booth, Larry I. Palmer

Faculty Publications

No abstract provided.

The Use Of Insecticide-Treated Nets For Reducing Malaria Morbidity Among Children Aged 6-59 Months, In An Area Of High Malaria Transmission In Central Côte D'Ivoire, Benjamin G. Koudou, Hala Ghattas Ph.D., Clémence Essé, Christian Nsanzabana, Fabian Rohner, Jürg Utzinger, Brian E. Faragher, Andres B. Tschannen

Faculty Publications

Background

Long-lasting insecticidal nets (LLINs) are an important tool for controlling malaria. Much attention has been devoted to determine both the effect of LLINs on the reduction of Plasmodium infection rate and on clinically-confirmed malaria cases in sub-Saharan Africa. We carried out an epidemiological study to investigate whether LLINs impact on Plasmodium prevalence rate and the proportion of clinically-confirmed malaria cases, in five villages in the district of Toumodi, central Côte d'Ivoire.

Methods

From April 2007 to November 2008, a community-based malaria control programme was implemented in the study villages, which involved large-scale distribution of LLINs, and training and sensitization …

Correlating Pharmaceutical Data With A National Health Survey As A Proxy For Estimating Rural Population Health, Ronald E. Cossman, Jeralynn S. Cossman, Wesley L. James, Troy Blanchard, Richard Thomas, Louis G. Pol, Arthur G. Cosby

Faculty Publications

Background: Chronic disease accounts for nearly three-quarters of US deaths, yet prevalence rates are not consistently reported at the state level and are not available at the sub-state level. This makes it difficult to assess trends in prevalence and impossible to measure sub-state differences. Such county-level differences could inform and direct the delivery of health services to those with the greatest need.Methods: We used a database of prescription drugs filled in the US as a proxy for nationwide, county-level prevalence of three top causes of death: heart disease, stroke, and diabetes. We tested whether prescription data are statistically valid proxy …

Heads Or Tails: L1 Insertion-Associated 5' Homopolymeric Sequences, Thomas J. Meyer, Deepa Srikanta, Erin M. Conlin, Mark A. Batzer

Faculty Publications

Background. L1s are one of the most successful autonomous mobile elements in primate genomes. These elements comprise as much as 17% of primate genomes with the majority of insertions occurring via target primed reverse transcription (TPRT). Twin priming, a variant of TPRT, can result in unusual DNA sequence architecture. These insertions appear to be inverted, truncated L1s flanked by target site duplications. Results. We report on loci with sequence architecture consistent with variants of the twin priming mechanism and introduce dual priming, a mechanism that could generate similar sequence characteristics. These insertions take the form of truncated L1s with hallmarks …

‘The Grass That Gets Trampled When Elephants Fight’: Will The Codification Of The Crime Of Aggression Protect Women?, Beth Van Schaack

Faculty Publications

This article analyzes the outcome of the Kampala process with an eye toward the rarely-considered gender aspects of the crime of aggression, whether or not the provisions adopted represent an advancement for women, and how aspects of feminist theory might interpret the new regime. The Article concludes that any impact of the provisions will inevitably be limited by gaps and ambiguities in the definition of the crime and the jurisdictional regime, which is premised on state consent and exempts non-states parties altogether. At the same time, the insertion of the crime of aggression in the Rome Statute enables the prosecution …

International Greenhouse Gas Offsets Under The Clean Air Act, Nathan D. Richardson

Faculty Publications

Offsets, and in particular international offsets, have been advanced as an important tool in climate policy, capable of significantly reducing the costs of emissions reductions. As attention turns to the existing CAA as a potential vehicle for general reduction of GHG emissions, an important question is whether regulation under the statute is compatible with international offsets. Certain regulatory programs under the CAA are likely candidates for GHG regulation, but many of them are legally incompatible with international offsets. Those programs that might permit use of international offsets have other problems that make them unpopular choices for GHG regulation. To the …

Three-Dimensional Structure Of The Weakly Associated Protein Homodimer Ser13 Using Rdcs And Paramagnetic Surface Mapping, Hsiau Wei Lee, Greg Wylie, Sonal Bansal, Xu Wang, Adam W. Barb, Megan A. Macnaughtan, Asli Ertekin, Gaetano T. Montelione, James H. Prestegard

Faculty Publications

The traditional NMR-based method for determining oligomeric protein structure usually involves distinguishing and assigning intra- and intersubunit NOEs. This task becomes challenging when determining symmetric homo-dimer structures because NOE cross-peaks from a given pair of protons occur at the same position whether intra- or intersubunit in origin. While there are isotope-filtering strategies for distinguishing intra from intermolecular NOE interactions in these cases, they are laborious and often prove ineffectual in cases of weak dimers, where observation of intermolecular NOEs is rare. Here, we present an efficient procedure for weak dimer structure determination based on residual dipolar couplings (RDCs), chemical shift …

A Global Census Of Fission Yeast Deubiquitinating Enzyme Localization And Interaction Networks Reveals Distinct Compartmentalization Profiles And Overlapping Functions In Endocytosis And Polarity, Ilektra Kouranti, Janel R. Mclean, Anna Feoktistova, Ping Liang, Alyssa E. Johnson, Rachel H. Roberts-Galbraith, Kathleen L. Gould

Faculty Publications

Ubiquitination and deubiquitination are reciprocal processes that tune protein stability, function, and/or localization. The removal of ubiquitin and remodeling of ubiquitin chains is catalyzed by deubiquitinating enzymes (DUBs), which are cysteine proteases or metalloproteases. Although ubiquitination has been extensively studied for decades, the complexity of cellular roles for deubiquitinating enzymes has only recently been explored, and there are still several gaps in our understanding of when, where, and how these enzymes function to modulate the fate of polypeptides. To address these questions we performed a systematic analysis of the 20 Schizosaccharomyces pombe DUBs using confocal microscopy, proteomics, and enzymatic activity …

Estimates Of Heritability For Reproductive Traits In Captive Rhesus Macaque Females, Christine Gagliardi, Kathrine P. Falkenstein, Donald E. Franke, H. Michael Kubisch

Faculty Publications

Records from a colony of captive Indian rhesus macaques (Macaca mulatta) were used to estimate heritability for a number of reproductive traits. Records were based on a total of 7,816 births by 1,901 females from 1979 to 2007. Heritability was estimated with a linear animal model using a multiple trait derivative free REML set of programs. Because no male parents were identified, the numerator relationship matrix contained female kinships established over six generations. Reproductive traits included female age at the birth of the first, second and last infant, age at death, inter-birth intervals, number of infants born per female and …

Delineation Of Differential Temporal Relations Between Specific Eating And Anxiety Disorders, Julia D. Buckner, Jose Silgado, Peter M. Lewinsohn

Faculty Publications

This study examined the temporal sequencing of eating and anxiety disorders to delineate which anxiety disorders increase eating disorder risk and whether individuals with eating disorders are at greater risk for particular anxiety disorders. The sample was drawn from the Oregon Adolescent Depression Project. Temporal relations between specific eating and anxiety disorders were examined after controlling for relevant variables (e.g., mood disorders, other anxiety disorders) over 14. years. After excluding those with anorexia nervosa (AN) in adolescence (T1), OCD was the only T1 anxiety disorder to predict AN by age 30 (T4). No T1 anxiety disorder was associated with T4 …

Commute Times, Food Retail Gaps, And Body Mass Index In North Carolina Counties, Stephanie B. Jilcott, Haiyong Liu, Justin B. Moore, Jeffrey W. Bethel, James Wilson, Alice S. Ammerman

Faculty Publications

Introduction: The prevalence of obesity is higher in rural than in urban areas of the United States, for reasons that are not well understood. We examined correlations between percentage of rural residents, commute times, food retail gap per capita, and body mass index (BMI) among North Carolina residents.

Methods: We used 2000 census data to determine each county's percentage of rural residents and 1990 and 2000 census data to obtain mean county-level commute times. We obtained county-level food retail gap per capita, defined as the difference between county-level food demand and county-level food sales in 2008, from the North Carolina …

Integrating Concepts And Technologies To Advance The Study Of Bird Migration, W. Douglas Robinson, Melissa Bowlin, Isabelle Bisson, Judy Shamoun-Barnes, Kasper Thorup, Robert H. Diehl, Thomas H. Kunz, Sarah Mabey, David W. Winkler

Faculty Publications

Recent technological innovation has opened new avenues in migration research - for instance, by allowing individual migratory animals to be followed over great distances and long periods of time, as well as by recording physiological information. Here, we focus on how technology - specifically applied to bird migration - has advanced our knowledge of migratory connectivity, and the behavior, demography, ecology, and physiology of migrants. Anticipating the invention of new and smaller tracking devices, in addition to the ways that technologies may be combined to measure and record the behavior of migratory animals, we also summarize major conceptual questions that …

The Body Soviet: Propaganda, Hygiene, And The Revolutionary State, Brian K. Lapierre

Faculty Publications

No abstract provided.

Practical Considerations In Establishing Sustainable International Nursing Experiences, Rae Jeanne Memmott, Catherine R. Coverston, Barbara A. Heise, Mary Williams, Erin D. Maughan, James Kohl, Sheri P. Palmer

Faculty Publications

An understanding of global health and the development of cultural competence are important outcomes of today's baccalaureate nursing programs. Thoughtfully designed International experiences can provide excellent opportunities to achieve those outcomes. Based Ono 16 years of providing International experiences within a baccalaureate curriculum, components are identified that contribute to the development of a sustainable international program. Areas addressed in the article are evaluating the fit with university and college mission, establishing the program within the university operational structure, selecting faculty and students, developing sites, designing a course, and program evaluation.

Postpartum Depression And Culture: Pesado Corazon, Lynn Clark Callister, Renea L. Beckstrand, Cheryl A. Corbett

Faculty Publications

The purpose of this article is to describe what the -literature has shown about postpartum depression (PPD) in culturally diverse women. The majority of qualitative studies done with women identified as -having PPD have been conducted with Western -women, with the second largest group focusing on Chinese women. This article reviews the qualitative studies in the literature and discusses how the management of PPD in technocentric and ethnokinship cultures differs. Social support has been shown to be significantly related to fewer symptoms of PPD, and culturally prescribed practices may or may not be -cultural mediators in decreasing the incidence of …

Neural Plasticity And Treatment-Induced Recovery Of Sentence Processing In Agrammatism, Cynthia K. Thompson, Dirk B. Den Ouden, Borna Bonakdarpour, Kyla Garibaldi, Todd B. Parrish

Faculty Publications

This study examined patterns of neural activation associated with treatment-induced improvement of complex sentence production (and comprehension) in six individuals with stroke-induced agrammatic aphasia, taking into account possible alterations in blood flow often associated with stroke, including delayed time-to-peak of the hemodynamic response function (HRF) and hypoperfused tissue. Aphasic participants performed an auditory verification fMRI task, processing object cleft, subject cleft, and simple active sentences, prior to and following a course of Treatment of Underlying Forms (TUR; Thompson et al., 2003), a linguistically based approach for treating aphasic sentence deficits, which targeted objective relative clause constructions. The patients also were …

Muscular And Performance Fitness And The Incidence Of Type 2 Diabetes: Prospective Study Of Japanese Men, Susumu S. Sawada, I-Min Lee, Hisashi Naito, Koji Tsukamoto, Takashi Muto, Steven N. Blair

Faculty Publications

Background: Limited data are available on the relationship between muscular and performance fitness (MPF) and the incidence of type 2 diabetes.

Methods: A cohort of 3792 Japanese men completed a medical examination that included MPF and cardiorespiratory fitness tests. MPF index composite score was calculated using Z-scores from vertical jump, sit-ups, side step, and functional reach tests.

Results: The mean follow-up period was 187 months (15.6 years). There were 240 patients who developed type 2 diabetes during follow-up. Relative risks and 95% confidence intervals (CI) for incidence of diabetes across baseline quartiles of MPF index composite score were obtained using …

Hopelessness, Depression, And Early Markers Of Endothelial Dysfunction In U.S. Adults, D. Phuong Do, Jennifer B. Dowd, Nalini Ranjit, James S. House, George A. Kaplan

Faculty Publications

Objective - This study examines whether the psychological traits of hopelessness and depressive symptoms are related to endothelial dysfunction.

Methods - Data come from a subsample of 434 respondents in the 2001-2003 Chicago Community Adult Health Study (CCAHS), a population-based survey designed to study the impact of psychological attributes, neighborhood environment, and socio-economic circumstances on adults age 18 and over. Circulating biomarkers of endothelial dysfunction including e-selectin, p-selectin and s-ICAM1 were obtained from serum samples. Hopelessness was measured by responses to two questions and depressive symptoms were measured by an 11-item version of the CES-D. Multivariate regression models tested whether …

Neighborhood Effects On Health: Concentrated Advantage And Disadvantage, Brian K. Finch, D. Phuong Do, Melonie Heron, Chloe E. Bird, Teresa Seeman, Nicole Lurie

Faculty Publications

We investigate an alternative conceptualization of neighborhood context and its association with health. Using an index that measures a continuum of concentrated advantage and disadvantage, we examine whether the relationship between neighborhood conditions and health varies by socio-economic status. Using NHANES III data geo-coded to census tracts, we find that while largely uneducated neighborhoods are universally deleterious, individuals with more education benefit from living in highly educated neighborhoods to a greater degree than individuals with lower levels of education.

Reducing Portion Size Reduces Food Intake And Plate Waste, Marjorie Freedman, Carolina Brochado

Faculty Publications

As portion size (PS) increases, so does food intake. The effect of decreasing PS on food intake in a nonlaboratory setting is unknown. This 5-week study sought to determine whether decreasing PS resulted in decreased intake of the same food, and if so, at what point further PS reductions might lack benefit. It also assessed effects of PS reduction on food production and waste in a university all-you-can-eat dining facility (DF). Subjects were primarily freshmen who regularly ate lunch at the DF, and self-selected French fries (FF) presented in individual paper bags, portioned originally at 88 g, and decreased ∼15 …

A “Healthy Pizza Kitchen” Nutrition Education Program At A Children's Health Museum, Marjorie Freedman

Faculty Publications

For nutrition education to be successful in changing behavior, schools, families, and communities must participate in or provide a variety of diverse, creative, accessible, and culturally appropriate programs. One venue for provision of nutrition education is a health and science education center that has exhibits and special programs not found in an average school. Establishing relationships with these organizations could greatly enhance a school health curriculum.1 Although nutrition information, displays, and programming are often found in these centers, studies examining whether provision of nutrition education in these venues increases knowledge or changes behavior are lacking. The purpose of this study, …

Improving Immunization Rates In The Clinic And In The Community, Karlen E. (Beth) Luthy, Arlene M. Sperhac, Sandra A. Faux, Joseph K. Miner

Faculty Publications

Over the past decade, the United States haas had tremendous success in achieving very high immunization compliance rates among children, sometimes as high as 91%. However, despite progress toward controlling the spread of communicable disease through immunizations, more than 2.1 million children nationwide are not adequately immunized. Even among US children who are adequately immunized, only about half of them actually received their immunization on time.

Parenting In Emerging Adulthood: An Examination Of Parenting Clusters And Correlates, Larry J. Nelson, Laura M. Padilla-Walker, Katherine J. Christensen, Cortney A. Evans, Jason S. Carroll

Faculty Publications

The changing nature of the transition to adulthood in western societies, such as the United States, may be extending the length of time parents are engaged in “parenting” activities. However, little is known about different approaches parents take in their interactions with their emerging-adult children. Hence, this study attempted to identify different clusters of parents based on the extent to which they exhibited both extremes of control (psychological control, punishment, verbal hostility, indulgence) and responsiveness (knowledge, warmth, induction, autonomy granting), and to examine how combinations of parenting were related to emerging adult children’s relational and individual outcomes (e.g. parent–child relationship …

Where Is The Love?, Hyveth Williams

Faculty Publications

No abstract provided.

Insights Into Particle Formation And Remineralization Using The Short-Lived Radionuclide, Thorium-234, Kanchan Maiti, Claudia R. Benitez-Nelson, Ken O. Buesseler

Faculty Publications

[1] Simple mass balance models are applied to a high resolution 234Th profile from the northwest Pacific to examine the magnitude, rate, and depth distribution of particle remineralization processes below the euphotic zone (Ez). Here, excess 234Th (234Th > 238U) below the Ez is attributed to fragmentation processes that result in the conversion of sinking to non‐sinking particles. By considering particulate organic carbon (POC) to 234Th ratios on particles, we show that POC flux attenuation is larger than for 234Th, which we attribute to bacterial and zooplankton consumption of sinking POC. Three case studies are used to demonstrate how different combinations …

Kinetic And Spectroscopic Studies Of Hemin Acquisition In The Hemophore Hasap From Pseudomonas Aeruginosa, Erik T. Yukl, Grace Jepkorir, Aileen Y. Alontaga, Lawrence Pautsch, Juan C. Rodriguez, Mario Rivera, Pierre Moënne-Loccoz

Faculty Publications

The extreme limitation of free iron has driven various pathogens to acquire iron from the host in the form of heme. Specifically, several Gram-negative pathogens secrete a heme binding protein known as HasA to scavenge heme from the extracellular environment and to transfer it to the receptor protein HasR for import into the bacterial cell. Structures of heme-bound and apo-HasA homologues show that the heme iron(III) ligands, His32 and Tyr75, reside on loops extending from the core of the protein and that a significant conformational change must occur at the His32 loop upon heme binding. Here, we investigate the kinetics …