Digital Commons Network^™

Transitioning To Independence And Maintaining Research Careers In A New Funding Climate: American Society Of Preventive Oncology Junior Members Interest Group Report, Wendy C. Birmingham, Jada G. Hamilton, Parisa Tehranifar, Melinda L. Erwin, William M. P. Klein, Linda Nebeling, Jessica Chubak

Faculty Publications

The American Society of Preventive Oncology (ASPO) is a professional society for multi-disciplinary investigators in cancer prevention and control. The ASPO Junior Members Interest Group promotes the interests of predoctoral, postdoctoral, and junior faculty members within the Society, and provides them with career development and training opportunities. To this end, as part of the 37th ASPO Annual Meeting held in Memphis, Tennessee in March 2013, the Junior Members Interest Group organized a session designed to address issues faced by early-career investigators as they navigate the transition to become an independent, well-funded scientist with a sustainable program of research in the …

Elucidating Satisfaction With Physical Activity: An Examination Of The Day-To-Day Associations Between Experiences With Physical Activity And Satisfaction During Physical Activity Initiation, Scott A. Baldwin, Austin Baldwin, Valerie G. Loehr, Julie L. Kangas, Georita M. Frierson

Faculty Publications

Satisfaction with physical activity is known to be an important factor in physical activity maintenance, but the factors that influence satisfaction are not well understood. The purpose of this study was to elucidate how ongoing experiences with recently initiated physical activity are associated with satisfaction. Participants (n = 116) included insufficiently active volunteers who initiated a self-directed physical activity regimen and completed daily diaries about their experiences for 28 days. We used multilevel models to examine the associations between experiences with physical activity and satisfaction. Significant between-person effects demonstrated that people reporting higher average levels of positive experiences and lower …

Social Network Development, Language Use, And Language Acquisition During Study Abroad: Arabic Language Learners’ Perspectives, Dan Dewey, R. Kirk Belnap, Rebecca Hillstrom

Faculty Publications

Language learners and educators have subscribed to the belief that those who go abroad will have many opportunities to use the target language and will naturally become proficient. They also assume that language learners will develop relationships with native speakers allowing them to use the language and become more fluent, an assumption Pellegrino (Pellegrino, 1997, 1998) found to be held by study abroad participants. However, recent research has shown that students do not always use the language to the expected degree and that they often fall back on social relationships with native speakers of their own language (DeKeyser, 2007; Dewey, …

Young People’S Experiences Of Living With Type 1 Diabetes, Tina M. Taylor, Cheryl Scholes, Barbara Mandleco, Susanne Roper, Karen Dearing, Donna Freeborn

Faculty Publications

Scholes C et al (2013) Young people’s experiences of living with type 1 diabetes. Nursing Times; 109: 45, 23-25. Young people with type 1 diabetes mellitus face a unique set of challenges: their own and their family’s perspectives of the disease and treatment impact on how well they manage metabolic control. Hormonal changes, desire for autonomy and emotional distress can influence self-management. This study aimed to better understand the perspective of young people with diabetes and to find out whether metabolic rate affects how individuals’ view the disease and treatment. The findings are used to make suggestions for treatment approaches.

Satisfaction With Family Life Scale, Ramon B. Zabriskie, Peter J. Ward

Faculty Publications

We wanted to present validity and reliability data for the Satisfaction With Family Life (SWFL) scale. This instrument has been successfully used in a variety of family samples and offers a brief, widely applicable tool to measure satisfaction with family life. The SWFL scale, modeled after the Satisfaction With Life scale, was designed to assess an individual’s global judgment of family satisfaction, which is theoretically predicted to depend on a comparison of family life circumstances with one’s own standards and expectations. The scale consists of five items on a Likert-type scale. Data were collected from parents and adolescents in 15 …

Exploring The Effect Of Arousal And Valence On Mouse Interaction, G. Mark Grimes, Jeffrey L. Jenkins, Joseph S. Valacich

Faculty Publications

Determining a user’s affective state can be an important element when trying to understand human-computer interactions. Accurately assessing affect during system use, however, can be very difficult, especially in a non-laboratory setting. Extensive previous research in neuroscience has shown that arousal and valence influence motor control. In this research, the prior relevant neuroscience findings inform the investigation of mouse movement behavior under conditions of low and high arousal as well as positive and negative valence. A controlled laboratory experiment was conducted, providing support for hypotheses predicting that arousal and valence may be inferred by monitoring for differences in the distance, …

Effects Of Leadership On Financial Performance At The Local Level Of An Industrial Distributor, Rod L. Flanagan, Gary Stewardson, Jeffrey P. Dew, Michelle M. Fleig-Palmer, Edward Reeve

Faculty Publications

An important component in the industrial products supply chain is the distribution segment of the channel. The health and success of industrial distributors can often influence the success cess of manufacturers whom they represent. Although research has demonstrated how leadership is a key ingredient in the success of large corporations across industries, very little leadership research has been conducted in the industrial distribution market segment—especially at the local level. This research fills the gap between what is know about leadership in larger organizations, and the need for greater understanding of leadership at the local level of an industrial distributor. The …

Assessing Correlations Between Lingual Movements And Formants, Christopher Dromey, Gwi-Ok Jang, Kristi Hollis

Faculty Publications

First and second formant histories have been used in studies of both normal and disordered speech to indirectly measure the activity of the vocal tract. The purpose of the present study was to determine the extent to which formant measures are reflective of lingual movements during diphthong production. Twenty native speakers of American English from the western United States produced four diphthongs in a sentence context while tongue movement was measured with a magnetic tracking system. Correlations were computed between the vertical tongue movements and the first formant, as well as between the anteroposterior movements and the second formant during …

Taxpayers As Victims: Taxpayer Harm & Criminalization, Brenner M. Fissell

Faculty Publications

No abstract provided.

Economics And/Of Science: The Meaning(S) Of Financial Bias And The Ideal Of Interest-Free Science In Law, David S. Caudill

Faculty Publications

Images of scientific research and funding conventions are important in legal contexts when, for example, a trial judge or agency administrator evaluates the integrity of a scientific expert or risk assessment report — is industry affiliation or sponsorship of research a marker of bias, and should the results of “independent” research be given greater weight? In the discourse concerning the commercialization of science, there is a geography of positions reflecting different images of how science is affected by, or alternatively rises above, financial or economic pressures or entanglements. Of course, science costs and has always cost a lot of money, …

Preemption As Inverse Negligence Per Se, Michael P. Moreland

Faculty Publications

No abstract provided.

Molten Carbonates As An Effective Oxygen Reduction Catalyst For 550–650°C Solid Oxide Fuel Cells, Yunhui Gong, Xue Li, Lingling Zhang, Whitney Tharp, Changyong Qin, Kevin Huang

Faculty Publications

We report the first study that investigates the use of molten carbonates as an effective catalyst to promote electrochemical oxygen reduction reaction (ORR) at the cathode of intermediate temperature solid oxide fuel cells (IT-SOFCs). A series of binary Li-K carbonate compositions were incorporated into the porous backbones of a commercial cathode assembled in symmetrical impedance cells for electrochemical characterization. Within the temperature range of 550–650◦C, we observed that the polarization and ohmic area-specific resistances of the original sample can be significantly reduced by the introduction of molten carbonates. A new ORR charge-transfer model involving two intermediate species CO5 2− and …

Wave Propagation In Metamaterial Using Multiscale Resonators By Creating Local Anisotropy, Raiz U. Ahmed, Sourav Banerjee

Faculty Publications

Directional guiding, passing or stopping of elastic waves through engineered materials have many applications to the engineering fields. Recently, such engineered composite materials received great attention by the broader research community. In elastic waves, the longitudinal and transverse motion of material particles are coupled, which exhibits richer physics and demands greater attention than electromagnetic waves and acoustic waves in fluids. Waves in periodic media exhibit the property of Bragg scattering and create frequency band gaps in which the energy propagation is prohibited. However, in addition to the Bragg scattering, it has been found that local resonance of artificially designed resonators …

Eco-Terrorism Or Eco-Tage: An Argument For The Proper Frame, David Thomas Sumner, Lisa M. Weidman

Faculty Publications

What does the term “terrorism” mean? Is it accurate to lump illegal acts that destroy property but carefully avoid harming people into the same category as acts clearly intended to kill? Is this a difference of kind or just of degree? While we (the authors) don't generally endorse the destruction of property as a method of generating social change, we believe that the destruction of property is fundamentally different from the intentional killing of people; therefore, to label acts of obstruction, trespassing, vandalism, sabotage, or arson as “terrorism” is inaccurate and has the potential to damage one's understanding of real …

The Limits Of Violence: People And Property In Edward Abbey's "Monkeywrenching" Novels, David Thomas Sumner

Faculty Publications

This paper explores Edward Abbey’s fiction asking what kind of ethical imperative his monkeywrenching novels offer. While advocating the destruction of property in defense of wilderness, The Monkey Wrench Gang draws a clear ethical distinction between the destruction of property in defense of wilderness and the harming of people. Yet the sequel, Hayduke Lives!, blurs this ethical line when a security guard is killed during the novel’s final eco-sabotage scene. After exploring several possible textual explanations for this apparent change and then interviewing several of Abbey’s close friends regarding this issue, the author concludes that the shift does not …

Genomic Impact Of Eukaryotic Transposable Elements, Irina R. Arkhipova, Mark A. Batzer, Juergen Brosius, Cédric Feschotte, John V. Moran, Jürgen Schmitz, Jerzy Jurka

Faculty Publications

The third international conference on the genomic impact of eukaryotic transposable elements (TEs) was held 24 to 28 February 2012 at the Asilomar Conference Center, Pacific Grove, CA, USA. Sponsored in part by the National Institutes of Health grant 5 P41 LM006252, the goal of the conference was to bring together researchers from around the world who study the impact and mechanisms of TEs using multiple computational and experimental approaches. The meeting drew close to 170 attendees and included invited floor presentations on the biology of TEs and their genomic impact, as well as numerous talks contributed by young scientists. …

A Smartphone Design Approach To User Communication Interface For Administering Storage System Network, Weider Yu, Xiao Su, Jason Hansen

Faculty Publications

This paper investigates the feasibility and potential of using a mobile smartphone as a user administration control for storage system network. It includes the design and implementation of a mobile smartphone software system that can be used to perform system administration activities on the storage system without the need of using a laptop or desktop system. In the paper the design of some effective metaphors to present the storage system on the limited display area of a mobile smartphone device and the set of system features chosen for implementation are presented. Current storage system administration is limited to using storage …

Naturally Occurring Carboxypeptidase A6 Mutations: Effect On Enzyme Function And Association With Epilepsy, Matthew R. Sapio, Annick Salzmann, Monique Vessaz, Arielle Crespel, Peter J. Lyons, Alain Malafosse, Lloyd D. Fricker

Faculty Publications

Carboxypeptidase A6 (CPA6) is a member of the A/B subfamily of M14 metallocarboxypeptidases that is expressed in brain and many other tissues during development. Recently, two mutations in human CPA6 were associated with febrile seizures and/or temporal lobe epilepsy. In this study we screened for additional CPA6 mutations in patients with febrile seizures and focal epilepsy, which encompasses the temporal lobe epilepsy subtype. Mutations found from this analysis as well as CPA6 mutations reported in databases of single nucleotide polymorphisms were further screened by analysis of the modeled proCPA6 protein structure and the functional role of the mutated amino acid. …

Early Invitation To Food And/Or Multiple Micronutrient Supplementation In Pregnancy Does Not Affect Body Composition In Offspring At 54 Months: Follow-Up Of The Minimat Randomized Trial, Bangladesh, Ashraful Islam Khan, Iqbal Kabir, Sophie Hawkesworth, Eva‐Charlotte Ekström, Shams Arifeen, Edward A. Frongillo Jr., Lars Åke Persson

Faculty Publications

Growth patterns in early life are associated with later health.The effect of nutrition duringin uterodevelopmenton later body composition is unclear. We evaluated whether prenatal early invitation to food and/or multiplemicronutrient supplementation (MMS) in pregnancy has an effect on offspring body composition at 54 monthsof age. In Maternal and Infant Nutrition Interventions in Matlab trial (ISRCTN16581394) in Bangladesh, 4436pregnant women were randomised into six equally sized groups: double-masked supplementation with capsulesof either 30 mg Fe and 400mg folic acid, or 60 mg Fe and 400mg folic acid, or MMS (15 micronutrients), wascombined with a randomised early invitation (around 9 weeks) or …

Genomic And Physiological Footprint Of The Deepwater Horizon Oil Spill On Resident Marsh Fishes, Andrew Whitehead, Benjamin Dubansky, Charlotte Bodinier, Tzintzuni I. Garcia, Scott Miles, Chet Pilley, Vandana Raghunathan, Jennifer L. Roach, Nan Walker, Ronald B. Walter, Charles D. Rice, Fernando Galvez

Faculty Publications

The biological consequences of the Deepwater Horizon oil spill are unknown, especially for resident organisms. Here, we report results from a field study tracking the effects of contaminating oil across space and time in resident killifish during the first 4 mo of the spill event. Remote sensing and analytical chemistry identified exposures, which were linked to effects in fish characterized by genome expression and associated gill immunohistochemistry, despite very low concentrations of hydrocarbons remaining in water and tissues. Divergence in genome expression coincides with contaminating oil and is consistent with genome responses that are predictive of exposure to hydrocarbon-like chemicals …

Impact Of The Deepwater Horizon Oil Spill On A Deep-Water Coral Community In The Gulf Of Mexico, Helen K. White, Pen Yuan Hsing, Walter Cho, Timothy M. Shank, Erik E. Cordes, Andrea M. Quattrini, Robert K. Nelson, Richard Camilli, Amanda W.J. Demopoulos, Christopher R. German, James M. Brooks, Harry H. Roberts, William Shedd, Christopher M. Reddy, Charles R. Fisher

Faculty Publications

To assess the potential impact of the Deepwater Horizon oil spill on offshore ecosystems, 11 sites hosting deep-water coral communities were examined 3 to 4 mo after the well was capped. Healthy coral communities were observed at all sites >20 km from the Macondo well, including seven sites previously visited in September 2009, where the corals and communities appeared unchanged. However, at one site 11 km southwest of the Macondo well, coral colonies presented widespread signs of stress, including varying degrees of tissue loss, sclerite enlargement, excessmucous production, bleached commensal ophiuroids, and covering by brown flocculent material (floc). On the …

Impact Of Margin Size On The Predicted Risk Of Radiogenic Second Cancers Following Proton Arc Therapy And Volumetric Modulated Arc Therapy For Prostate Cancer, Laura A. Rechner, Rebecca M. Howell, Rui Zhang, Wayne D. Newhauser

Faculty Publications

We previously determined that the predicted risk of radiogenic second cancer in the bladder and rectum after proton arc therapy (PAT) was less than or equal to that after volumetric modulated arc therapy (VMAT) with photons, but we did not consider the impact of margin size on that risk. The current study was thus conducted to evaluate margin size's effect on the predicted risks of second cancer for the two modalities and the relative risk between them. Seven treatment plans with margins ranging from 0 mm in all directions to 6 mm posteriorly and 8 mm in all other directions …

Prevalence And Predictors Of Giving Birth In Health Facilities In Bugesera District, Rwanda, Shahrzad Joharifard, Stephen Rulisa, Francine Niyonkuru, Andrew Weinhold, Felix Sayinzoga, Jeffrey Wilkinson, Jan Ostermann, Nathan M. Thielman

Faculty Publications

Background The proportion of births attended by skilled health personnel is one of two indicators used to measure progress towards Millennium Development Goal 5, which aims for a 75% reduction in global maternal mortality ratios by 2015. Rwanda has one of the highest maternal mortality ratios in the world, estimated between 249–584 maternal deaths per 100,000 live births. The objectives of this study were to quantify secular trends in health facility delivery and to identify factors that affect the uptake of intrapartum healthcare services among women living in rural villages in Bugesera District, Eastern Province, Rwanda.

Methods Using census data …

Assessing Treatment Integrity: A Case Example, Anat Zeira, Betty Blythe, Anita Reithoffer Tucker

Faculty Publications

This paper presents an example of assessing treatment integrity as part of an experimental study of home-based, intensive family preservation services (IFPS). Participants were 103 IFPS workers and 24 state public child welfare agency workers (FC). The structured, self-report questionnaire included questions about specific components of the services, as well as the characteristics of the family and the workers themselves. Findings suggest that IFPS workers delivered services according to the treatment model guidelines. The procedure yielded a good estimate of whether the structural components of treatment were delivered according to the model as delineated in the treatment manual. The paper …

Lines In The Sand: Social Representations Of Substance Use Boundaries In Life Narratives, K. F. Trocki, L. O. Michalak, Laurie A. Drabble

Faculty Publications

This study identifies social representations in interviews about alcohol and substance use in the discourse of 129 young adults, who were interviewed for 2.5 to 3.5 hr each for their life histories and use or nonuse of alcoholic beverages and drugs. Respondents spontaneously delineated their substance use boundaries, creating a continuum of behaviors with boundary points separating acceptable from unacceptable behaviors. They used signaling expressions to indicate go and stop signs and movement along the substance use continuum and reported negotiating substance use boundaries both internally and with peers. A ubiquitous narrative element was the cautionary tale, in which a …

Hostile Mood And Social Strain During Daily Life: A Test Of The Transactional Model., Elizabeth J. Vella, Thomas W. Karmarck, Janine D. Flory, Stephen B. Manuck

Faculty Publications

Hostility is a multidimensional construct related to cardiovascular (CV) disease risk. Daily hostile mood and social interactions may precipitate stress-related CV responses in hostile individuals. Purpose: Determine whether trait cognitive hostility best predicts daily hostile mood and social interactions relative to other trait hostility factors and explore the temporal links between these daily measures

Inside Voices: Protecting The Student-Critic In Public Schools, Josie F. Brown

Faculty Publications

First Amendment doctrine acknowledges the constructive potential of citizens’ criticism of public officials and governmental policies by offering such speech vigilant protection. However, when students speak out about perceived injustice or dysfunction in their public schools, teachers and administrators too often react by squelching and even punishing student-critics. To counteract school officials’ reflexively repressive responses to student protest and petition activities, this Article explains why the faithful performance of public schools’ responsibility to prepare students for constitutional citizenship demands the adoption of a more receptive and respectful attitude toward student dissent. After documenting how both educators and courts have mistakenly …

Beyond Law Enforcement: Camreta V. Greene, Child Protection Investigations, And The Need To Reform The Fourth Amendment Special Needs Doctrine, Josh Gupta-Kagan

Faculty Publications

The Fourth Amendment “special needs” doctrine distinguishes between searches and seizures that serve the “normal need for law enforcement” and those that serve some other “special need,” excusing non-law enforcement searches and seizures from the warrant and probable cause requirements. The Supreme Court has never justified drawing this bright line exclusively around law enforcement searches and seizures but not those that threaten important non-criminal constitutional rights.

Child protection investigations illustrate the problem: Millions of times each year, state child protection authorities search families’ homes, and seize children for interviews about alleged maltreatment. Only a minority of these investigations involve an …

Jak/Stat3 Signaling Promotes Somatic Cell Reprogramming By Epigenetic Regulation, Yong Tang, Yan Luo, Zongliang Jiang, Yinghong Ma, Chih Jen Lin, Chul Kim, Mark G. Carter, Tomokazu Amano, Joonghong Park, Sharon Kish, Xiuchun Tian

Faculty Publications

Although leukemia inhibitory factor (LIF) maintains the ground state pluripotency of mouse embryonic stem cells and induced pluripotent stem cells (iPSCs) by activating the Janus kinase/signal transducer and activator of transcription 3 (Jak/Stat3) pathway, the mechanism remained unclear. Stat3 has only been shown to promote complete reprogramming of epiblast and neural stem cells and partially reprogrammed cells (pre-iPSCs). We investigated if and how Jak/Stat3 activation promotes reprogramming of terminally differentiated mouse embryonic fibroblasts (MEFs). We demonstrated that activated Stat3 not only promotes but also is essential for the pluripotency establishment of MEFs during reprogramming. We further demonstrated that during this …

Competition Of Zinc Ion For The [2fe-2s] Cluster Binding Site In The Diabetes Drug Target Protein Mitoneet, Guoqiang Tan, Aaron P. Landry, Ruili Dai, Li Wang, Jianxin Lu, Huangen Ding

Faculty Publications

Human mitochondrial protein mitoNEET is a novel target of type II diabetes drug pioglitazone, and contains a redox active [2Fe-2S] cluster that is hosted by a unique ligand arrangement of three cysteine and one histidine residues. Here we report that zinc ion can compete for the [2Fe-2S] cluster binding site in human mitoNEET and potentially modulate the physiological function of mitoNEET. When recombinant mitoNEET is expressed in Escherichia coli cells grown in M9 minimal media, purified mitoNEET contains very little or no iron-sulfur clusters. Addition of exogenous iron or zinc ion in the media produces mitoNEET bound with a [2Fe-2S] …