Digital Commons Network^™

Replacing The Axial Ligand Tyrosine 75 Or Its Hydrogen Bond Partner Histidine 83 Minimally Affects Hemin Acquisition By The Hemophore Hasap From Pseudomonas Aeruginosa, Ritesh Kumar, Hirotoshi Matsumura, Scott Lovell, Huili Yao, Juan C. Rodríguez, Kevin P. Battaile, Pierre Moënne-Loccoz, Mario Rivera

Faculty Publications

Hemophores from Pseudomonas aeruginosa (HasAp), Serratia marcescens (HasAsm), and Yersinia pestis (HasAyp) bind hemin between two loops. One of the loops harbors conserved axial ligand Tyr75 (Y75 loop) in all three structures, whereas the second loop (H32 loop) contains axial ligand His32 in HasAp and HasAsm, but a noncoordinating Gln32 in HasA yp. Binding of hemin to the Y75 loop of HasAp or HasAsm causes a large rearrangement of the H32 loop that allows His32 coordination. The Q32 loop in apo-HasAyp is already in the closed conformation, such that binding of hemin to the conserved Y75 loop occurs with minimal …

Extracurricular School-Based Sports As A Motivating Vehicle For Sports Participation In Youth: A Cross-Sectional Study, An V. De Meester, Nathalie Aelterman, Greet Cardon, Ilse De Bourdeaudhuij, Leen Haerens

Faculty Publications

Background

Extracurricular school-based sports are considered to be an ideal means of reaching children who are not active in community sports. The purposes of this study were to examine the extent to which pupils not engaging in community sports do participate in extracurricular school-based sports, and to assess whether extracurricular school-based sports participants are more physically active and/or more autonomously motivated towards sports in daily life than children who do not participate in extracurricular school-based sports.

Methods

One thousand forty-nine children (53.7% boys; M age = 11.02 years, SD = 0.02) out of 60 classes from 30 Flemish elementary schools, …

School And Community-Based Childhood Obesity: Implications For Policy And Practice, Suzette Fromm Reed, Judah J. Viola, Karen Lynch

Faculty Publications

This introduction to a special issue of the Journal of Prevention and Intervention in the Community on the topic of childhood obesity prevention lays some of the basis for the state of affairs of the childhood obesity epidemic in the United States as of 2012 and the need for and types of existing prevention and intervention efforts underway. At the intersection of public health and community psychology, each of the five articles presents some insights into how prevention and intervention efforts currently underway are fairing and offers some implications for program developers and policy makers to start to turn around …

Transcriptional Activation Of Antioxidants May Compensate For Selenoprotein Deficiences In Amblyomma Maculatum (Acari: Ixodidae) Injected With Selk- Or Selm- Dsrna, S. Adamson, R. Browning, P. Singh, S. Nobles, A. Villareal, Shahid Karim

Faculty Publications

The Gulf‐Coast tick, Amblyomma maculatum, possesses an elaborate set of selenoproteins, which prevent the deleterious effects from oxidative stress that would otherwise occur during feeding. In the current work, we examined the role of selenoprotein K (SelK) and selenoprotein M (SelM) in feeding A. maculatum by bioinformatics, transcriptional gene expression, RNA interference and antioxidant assays. The transcriptional expression of SelK did not vary significantly in salivary glands or midguts throughout the bloodmeal. However, there was a 58‐fold increase in transcript levels of SelM in tick midguts. Ticks injected with selK‐dsRNA or selM‐dsRNA did not reveal any observable …

Improvements In Blood Pressure Among Undiagnosed Hypertensive Participants In A Community-Based Lifestyle Intervention, Mississippi, 2010, Jamie M. Zoellner, Jessica L. Thomson, Alicia S. Landry, Charkarra Anderson-Lewis, Carol Connell, Elaine Fontenot Molaison, Kathleen Yadrick

Faculty Publications

Introduction

Effective strategies are needed to reach and treat people who lack awareness of or have uncontrolled hypertension. We used data from a community-based participatory research initiative, Hub City Steps, to quantify the prevalence of undiagnosed hypertension and determine the relationship between hypertension status at baseline and postintervention improvements in blood pressure and health-related quality of life.

Methods

Hub City Steps was a 6-month preintervention–postintervention lifestyle intervention targeting hypertension risk factors. Outcome measures were collected at baseline, 3 months, and 6 months. Generalized linear mixed models were used to test for effects by time and hypertension status.

Results

Of the …

We Are Our Stories: Narrative Dimension Of Human Identity And Its Implications For Christian Faith Formation, Rolf A. Jacobson

Faculty Publications

Increasingly, representatives of diverse disciplines have come to a significant consensus about human identity. Each of us constructs and lives in a narrative that is, in fact, us. If this is the case, we will need an outside source to construct a narrative that is both good and true—one to which and in which we can give our lives. Such a story is given us in Holy Scripture and in the collective memory of the church.

Politics Then And Now, In Maine And The Nation Conversations With The Sages, Richard Barringer, Kenneth Palmer

Faculty Publications

No abstract provided.

Hydraulic Fracturing On Federal And Indian Lands: An Analysis Of The Bureau Of Land Management's Revised Proposed Rule, Nathan D. Richardson, Alan Krupnick, Madeline Gottlieb, Molly Feiden

Faculty Publications

The federal government controls 700 million acres of subsurface rights (plus 56 million subsurface acres of Indian mineral estate) across 24 states, making it the largest landowner in the nation, and therefore in a position to negotiate lease terms and shape regulations of oil and gas development. The federal Bureau of Land Management’s (BLM) rules on how drilling activity can take place on federal lands essentially dictate terms, making BLM the largest “regulator” of drilling activity in the country. BLM last revised its oil and gas regulations (the Onshore Orders) in the 1980s and early 1990s, well before the recent …

Automated Vehicles Are Probably Legal In The United States, Bryant Walker Smith

Faculty Publications

This article provides the most comprehensive discussion to date of whether so-called automated, autonomous, self-driving, or driverless vehicles can be lawfully sold and used on public roads in the United States. The short answer is that the computer direction of a motor vehicle’s steering, braking, and accelerating without real-time human input is probably legal. The long answer, which follows, provides a foundation for tailoring regulations and understanding liability issues related to these vehicles.

The article’s largely descriptive analysis, which begins with the principle that everything is permitted unless prohibited, covers three key legal regimes: the 1949 Geneva Convention on Road …

Unpermitted Urban Agriculture: Transgressive Actions, Changing Norms And The Local Food Movement, Sarah B. Schindler

Faculty Publications

Roberta keeps four chickens in her backyard. Bob snuck onto the vacant lot next door, which the bank foreclosed upon and now owns, and planted a vegetable garden. Vien operates an occasional underground restaurant from his friends’ microbrewery after beer-making operations cease for the day. The common thread tying these actions together is that they are unauthorized; they are being undertaken in violation of existing laws and often norms. In this Article, I explore ideas surrounding the overlap between food policy and land use law, specifically the transgressive1 actions that people living in urban and suburban communities are undertaking to …

Anger Problems And Posttraumatic Stress Disorder In Male And Female National Guard And Reserve Service Members, Miranda E. Worthen, S D. Rathod, G. Cohen, L. Sampson, R. Ursano, R. Gifford, C. Fullerton, S. Galea, J. Ahern

Faculty Publications

Anger is a common problem among veterans and has been associated with posttraumatic stress disorder (PTSD). This study aimed to improve understanding of how anger and PTSD co-occur by examining gender differences and differences by whether the triggering traumatic event is deployment-related vs. civilian-related in current service members. A representative cohort of Reserve and National Guard service personnel (n = 1293) were interviewed to assess for deployment- or civilian-related traumas, PTSD, and anger. The prevalence of self-reported anger problems was estimated among male (n = 1036) and female (n = 257) service members. Log Poisson regression models with robust standard …

Leonard Knight 1931-2014, Jo Farb Hernandez

Faculty Publications

No abstract provided.

Concordance Between The Chang And The International Society Of Pediatric Oncology (Siop) Ototoxicity Grading Scales In Patients Treated With Cisplatin For Medulloblastoma, Johnnie Bass, Jie Huang, Arzu Onar-Thomas, Kay Chang, Shaum Bhagat, Murali Chintagumpala, Ute Bartels, Sridharan Gururangan, Tim Hassall, John Heath, Geoffrey Mccowage, Richard Cohn, Michael Fisher, Giles Robinson, Alberto Broniscer, Amar Gajjar, James Gurney

Faculty Publications

BackgroundReporting ototoxicity is frequently complicated by use of various ototoxicity criteria. The International Society of Pediatric Oncology (SIOP) ototoxicity grading scale was recently proposed for standardized use in reporting hearing loss outcomes across institutions. The aim of this study was to evaluate the concordance between the Chang and SIOP ototoxicity grading scales. Differences between the two scales were identified and the implications these differences may have in the clinical setting were discussed.ProceduresAudiological evaluations were reviewed for 379 patients with newly diagnosed medulloblastoma (ages 3–21 years). Each patient was enrolled on one of two St. Jude clinical protocols that included craniospinal …

Disability, Development, And Human Rights: A Mandate And Framework For International Financial Institutions, Michael Ashley Stein, Penelope J. S. Stein

Faculty Publications

No abstract provided.

Mental Illness And Danger To Self, Cynthia V. Ward

Faculty Publications

No abstract provided.

Impact Of Uniform Laws On The Teaching Of Trusts And Estates, David M. English

Faculty Publications

Beginning in 1969 with the approval of the Uniform Probate Code (UPC), uniform laws have had a major impact on the teaching of the basic Trusts and Estates course. This is not the place to list the close to thirty uniform acts relating to Trusts and Estates that have been approved. Rather, this Article will focus on the impact that uniform laws have had on the content of what is taught in the Trusts and Estates course. Uniform laws are not written in a vacuum. Like other legislative enactments, they are the product of societal changes and changes in legal …

Hub City Steps: A 6-Month Lifestyle Intervention Improves Blood Pressure Among A Primarily African-American Community, Jamie M. Zoellner, Carol Connell, Michael B. Modson, Jessica L. Thomson, Alicia S. Landry, Elaine Fontenot Molaison, Vickie Blakely Reed, Kathleen Yadrick

Faculty Publications

The effectiveness of community-based participatory research (CBPR) efforts to address the disproportionate burden of hypertension among African Americans remains largely untested. The objective of this 6-month, noncontrolled, pre-/post-experimental intervention was to examine the effectiveness of a CBPR intervention in achieving improvements in blood pressure, anthropometric measures, biological measures, and diet. Conducted in 2010, this multicomponent lifestyle intervention included motivational enhancement, social support provided by peer coaches, pedometer diary self-monitoring, and monthly nutrition and physical activity education sessions. Of 269 enrolled participants, 94% were African American and 85% were female. Statistical analysis included generalized linear mixed models using maximum likelihood estimation. …

Women, Unions, And Negotiation, Nicole Buonocore Porter

Faculty Publications

In a period when union membership is at an all-time low (at least in the private sector), some (or perhaps many) people have given up hope that the labor movement can be revived. I believe that the labor movement still has the potential to be successful but needs to be re-imagined and reinvigorated. One way (among many) of doing this is to increase women's attachment to the labor movement. Now that women comprise nearly 47 percent of the workforce, it makes sense to have a concentrated effort to increase their union participation.

Not only will more women in unions increase …

Unequal Protection Under The Law: Why Fda Should Use Negotiated Rulemaking To Reform The Regulation Of Generic Drugs, Marie C. Boyd

Faculty Publications

The duty to ensure the safety of drug products, through adequate warnings or other means, should ultimately rest with the drug's manufacturer regardless of whether the drug is a generic drug or a brand-name drug. Recent U.S. Supreme Court holdings, however, suggest that while the manufacturer of a brand-name drug is always responsible for its label's content, this is not the case for generic drugs. In addition, by holding that failure-to-warn claims against generic drug manufacturers based on state law are preempted, the Court has removed the protections and compensation that state tort law can provide consumers of generic drugs …

Health Insurance Status, Psychological Processes, And Older African Americans' Use Of Preventive Care, Catherine Walker O'Neal, Kandauda A.S. Wickrama, Penny A. Ralston, Jasminka Z. Elich, Cynthia M. Harris, Catherine Coccia, Iris Young-Clark, Jennifer Lemacks

Faculty Publications

The current study examined the influence of health insurance, psychological processes (i.e. psychological competency and vulnerability), and the interaction of these two constructs on older African Americans' utilization of five preventive care services (e.g. cholesterol screening and mammogram/prostate examination) using data from 211 older African Americans (median age = 60). In addition to direct effects, the influence of health insurance sometimes varied depending on respondents' psychological competency and/or vulnerability. Policies and interventions to increase older African Americans' use of preventive health services should consider structural (e.g. health insurance) and psychological (e.g. psychological competency and vulnerability) factors along with the interaction …

The Value Of Life: Constitutional Limits On Citizens’ Use Of Deadly Force, F. Patrick Hubbard

Faculty Publications

This Article argues that most states have unconstitutionally overbroad authorizations for citizens to use deadly force in the context of crime prevention, citizen’s arrest, and defense of one’s “castle.” Similarly, some authorizations of deadly force for self-defense in public areas may be unconstitutional. The starting points of this argument are the fundamental value of life, the state’s monopoly of deadly force, and the fundamental constitutional right to life. Because of the state’s monopoly of deadly force, any use of such force is either legitimate or proscribed. The lack of a third category of “private” use of deadly force affects constitutional …

Pharmacy Compounding After The Drug Quality And Security Act, Erika Lietzan

Faculty Publications

On November 27, 2013, President Obama signed into law the Drug Quality and Security Act ("DQSA"), which amends the Federal Food, Drug, and Cosmetic Act ("FDCA") to add statutory provisions addressing drug compounding and supply chain issues. This article discusses Title I of this legislation, known as the Compounding Quality Act, and draft compounding guidances subsequently issued by the Food and Drug Administration ("FDA"). Section I provides a brief history of FDA's regulation of compounding activities before the Compounding Quality Act's enactment. Section II reviews the Compounding Quality Act and FDA's new draft guidances. Section III considers some of the …

Pushing Back From The Table, Nicole A. Cooke

Faculty Publications

No abstract provided.

Cost-Savings Achieved In Two Semesters Through The Adoption Of Open Educational Resources, John Hilton Iii, T. Jared Robinson, David Wiley, J. Dale Ackerman

Faculty Publications

Textbooks represent a significant portion of the overall cost of higher education in the United States. The burden of these costs is typically shouldered by students, those who support them, and the taxpayers who fund the grants and student loans which pay for textbooks. Open educational resources (OER) provide students a way to receive high-quality learning materials at little or no cost to students. We report on the cost savings achieved by students at eight colleges when these colleges began utilizing OER in place of traditional commercial textbooks.

Choices, Bias, And The Value Of The Paycheck Fairness Act: A Response Essay, Nicole Buonocore Porter

Faculty Publications

In the previous article written by Gary Siniscalco, Lauri Damrell, and Clara Morain Nabity [The Pay Gap, the Glass Ceiling, and Pay Bias: Moving Forward Fifty Years After the Equal Pay Act], the authors argue that the pay gap is not primarily caused by employer discrimination, but rather can be attributed to many factors, including the "glass ceiling" and choices made by women regarding occupation, caregiving, and commitment to the workforce. Thus, they argue that we should not place blame on employers and focus on the reach of anti-discrimination laws, and should instead acknowledge that there is a …

Finding A Fix For The Fmla: A New Perspective, A New Solution, Nicole Buonocore Porter

Faculty Publications

When the Family and Medical Leave Act ("FMLA") was enacted in 1993, it was considered landmark legislation.... Yet, despite the promise of the FMLA, by almost all accounts it has not achieved much.... Over the years, scholars have proposed many solutions to improve the FMLA.

[...]

In this article, I am taking a different perspective and proposing a reform that I have not seen proposed before. Of all of the problems with the FMLA, the one that gets the least attention is the frequency with which employees abuse their rights under the FMLA and the difficulty employers have administering the …

From "War On Poverty" To Pro Bono: Access To Justice Remains Elusive For Too Many, Including Our Veterans, Patricia E. Roberts

Faculty Publications

Fifty years ago, President Lyndon B. Johnson launched the War on Poverty. The Legal Services Program of 1965, along with the Legal Services Corporation formed in 1974, considerably increased civil legal aid to America’s poor. Yet today, there is only one legal aid attorney for every 6,415 people living in poverty. Veterans, comprising 4.6%of those living in poverty, often suffer additional obstacles and extensive legal needs, including assistance in obtaining benefits to which they are entitled. While encouraging additional pro bono service among attorneys incrementally increases the availability of legal services to the poor, law school clinics across the country …

Mir-200, A New Star Mirna In Human Cancer, Xiangling Feng, Zhengming Wang, Rebecca Fillmore, Yaguang Xi

Faculty Publications

MicroRNAs (miRNAs) are a set of non-coding small RNA molecules in control of gene expression at posttranscriptional/translational level. They not only play crucial roles in normal developmental progress, but also are commonly dysregulated in human diseases, including cancer. MiR-200 is a family of tumor suppressor miRNAs consisting of five members, which are significantly involved in inhibition of epithelial-to-mesenchymal transition (EMT), repression of cancer stem cells (CSCs) self-renewal and differentiation, modulation of cell division and apoptosis, and reversal of chemoresistance. In this article, we summarize the latest findings with regard to the tumor suppressor signatures of miR-200 and the regulatory mechanisms …

Concentrations And Sources Of Polycyclic Aromatic Hydrocarbons In Surface Coastal Sediments Of The Northern Gulf Of Mexico, Zucheng Wang, Zhanfei Liu, Kehui Xu, Lawrence M. Mayer, Zulin Zhang, Alexander S. Kolker, Wei Wu

Faculty Publications

Background: Coastal sediments in the northern Gulf of Mexico have a high potential of being contaminated by petroleum hydrocarbons, such as polycyclic aromatic hydrocarbons (PAHs), due to extensive petroleum exploration and transportation activities. In this study we evaluated the spatial distribution and contamination sources of PAHs, as well as the bioavailable fraction in the bulk PAH pool, in surface marsh and shelf sediments (top 5 cm) of the northern Gulf of Mexico. Results: PAH concentrations in this region ranged from 100 to 856 ng g(-1), with the highest concentrations in Mississippi River mouth sediments followed by marsh sediments and then …

Examining Religious Commitment, Perfectionism, Scrupulosity, And Well-Being Among Lds Individuals, Kawika Allen, Kenneth T. Wang

Faculty Publications

This study examined the relationships and interactions between religious commitment, perfectionism, scrupulosity, and psychological well-being among Latter-Day Saints (LDS or Mormons). The results showed a positive association between religious commitment and satisfaction with life. Scrupulosity partially mediated the relationship between maladaptive perfectionism and depression, anxiety, and satisfaction with life. The sample majority was classified as adaptive perfectionists, reporting higher intra- and interpersonal religious commitment, self-esteem, and satisfaction with life, and lower levels of anxiety and depression than the maladaptive and nonperfectionists. Additional results are provided. Implications of these findings are outlined.