Digital Commons Network^™

Guarding The Center, Gerald A. Klingbeil

Faculty Publications

No abstract provided.

Association Between Toxoplasma Gondii Seropositivity And Memory Function In Non-Demented Older Adults, Cynthia Elizabeth Wyman, Shawn D. Gale, Ariana Hedges-Muncy, Lance D. Erickson, Eric Wilson, Dawson W. Hedges

Faculty Publications

Toxoplasma gondii (T. gondii) seropositivity may be associated with decreased memory in older adults. To further investigate the association between T. gondii seropositivity and memory in nondemented older adults, we obtained serum samples from 114 non-demented older adults evaluated by the Alzheimer’s Disease and Research Center at Washington University in St. Louis Missouri, USA. We determined T. gondii seropositivity and anti-T. gondii IgG antibody titer and examined associations with memory function while controlling for socioeconomic status, education level, age, and apolipoprotein E4 status. There were few associations between T. gondii seropositivity or anti-T. gondii IgG antibodies and memory, although there …

Effectiveness Of Integrative Restoration (Irest) Yoga Nidra On Mindfulness, Sleep, And Pain In Health Care Workers, Eva Livingston, Katreena Collette Merrill

Faculty Publications

This article examines the effectiveness of Integrative Restoration (iRest) Yoga Nidra meditation on mindfulness, sleep, and pain in health care workers. As health care workers provide emotional support to patients, it is not uncommon for workers to experience both physical and mental exhaustion. One holistic approach to support employees is mindfulness training. iRest Yoga Nidra is a complementary and integrative health therapy that increases mindfulness. A pre-/postinterveniton descriptive survey design was used. Before and after experiencing iRest meditation, participants completed a 51-item questionnaire consisting of demographics plus 3 validated instruments: the Five-Facet Mindfulness Questionnaire (FFMQ), the Epworth Sleepiness Scale (ESS), …

Characterizing Severe Weather Potential In Synoptically Weakly Forced Thunderstorm Environments, Paul W. Miller, Thomas L. Mote

Faculty Publications

Abstract. Weakly forced thunderstorms (WFTs), short-lived convection forming in synoptically quiescent regimes, are a contemporary forecasting challenge. The convective environments that support severe WFTs are often similar to those that yield only non-severe WFTs and, additionally, only a small proportion of individual WFTs will ultimately produce severe weather. The purpose of this study is to better characterize the relative severe weather potential in these settings as a function of the convective environment. Thirty-one near-storm convective parameters for > 200 000 WFTs in the Southeastern United States are calculated from a high-resolution numerical forecasting model, the Rapid Refresh (RAP). For each parameter, …

The Right Tool For Trade Relations With China, Anna M. Han, Colleen Chien

Faculty Publications

In life, it’s important to have the right tool for the job, and trade is no different. The technology and intellectual property issues at the heart of the recent US-China trade dispute are complex and nuanced. Tariffs are a big stick good for shaking at partners but also, as the stock markets dramatic reaction shows us, capable of great collateral damage. And so, as an alternative to the blunt instrument of tariffs, we propose some surgical policy interventions, unilateral and bilateral, for moving forward.

The US Trade Representative’s premise for the sanctions is nothing new—that US companies are tired of …

Cross-Participant Eeg-Based Assessment Of Cognitive Workload Using Multi-Path Convolutional Recurrent Neural Networks, Ryan G. Hefron, Brett J. Borghetti, Christine M. Schubert Kabban, James Christensen, Justin Estep

Faculty Publications

Applying deep learning methods to electroencephalograph (EEG) data for cognitive state assessment has yielded improvements over previous modeling methods. However, research focused on cross-participant cognitive workload modeling using these techniques is underrepresented. We study the problem of cross-participant state estimation in a non-stimulus-locked task environment, where a trained model is used to make workload estimates on a new participant who is not represented in the training set. Using experimental data from the Multi-Attribute Task Battery (MATB) environment, a variety of deep neural network models are evaluated in the trade-space of computational efficiency, model accuracy, variance and temporal specificity yielding three …

Industrial Cyber Vulnerabilities: Lessons From Stuxnet And The Internet Of Things, Lawrence J. Trautman, Peter C. Ormerod

Faculty Publications

Cyber breaches continue at an alarming pace with new vulnerability warnings an almost daily occurrence. Discovery of the industrial virus Stuxnet during 2010 introduced a global threat of malware focused toward disruption of industrial control devices. By the year 2020, it is estimated that over 30 billion Internet of Things (IoT) devices will exist. The IoT global market spend is estimated to grow from $591.7 billion in 2014 to $1.3 trillion in 2019 with a compound annual growth rate of 17%. The installed base of IoT endpoints will grow from 9.7 billion in 2014 to more than 25.6 billion in …

Uncertainty Evaluation In The Design Of Structural Health Monitoring Systems For Damage Detection, Christine M. Schubert Kabban, Richard P. Uber, Kevin J. Lin, Bin Lin, M. Bhuiyan, Victor Giurgiutiu

Faculty Publications

The validation of structural health monitoring (SHM) systems for aircraft is complicated by the extent and number of factors that the SHM system must demonstrate for robust performance. Therefore, a time- and cost-efficient method for examining all of the sensitive factors must be conducted. In this paper, we demonstrate the utility of using the simulation modeling environment to determine the SHM sensitive factors that must be considered for subsequent experiments, in order to enable the SHM validation. We demonstrate this concept by examining the effect of SHM system configuration and flaw characteristics on the response of a signal from a …

Uncertainty Evaluation In The Design Of Structural Health Monitoring Systems For Damage Detection, Christine Schubert Kabban, Richard Uber, Kevin Lin, Bin Li, Md Yeasin Bhuiyan, Victor Giurgiutiu

Faculty Publications

The validation of structural health monitoring (SHM) systems for aircraft is complicated by the extent and number of factors that the SHM system must demonstrate for robust performance. Therefore, a time- and cost-efficient method for examining all of the sensitive factors must be conducted. In this paper, we demonstrate the utility of using the simulation modeling environment to determine the SHM sensitive factors that must be considered for subsequent experiments, in order to enable the SHM validation. We demonstrate this concept by examining the effect of SHM system configuration and flaw characteristics on the response of a signal from a …

Exploring Screen Time Habits And The Life Empowerment Divide At An Hbcu, Kim Smith, Tobin Walton, Alvin Keyes

Faculty Publications

College students at a historically black university used their social media accounts to recruit 1,232 of their peers to take an online survey that explored digital screen time and social media habits at this HBCU. The study revealed that 51% devoted daily screen time to academic empowerment, 31% devoted it to leisure, and 11% devoted it to life empowerment. Sixty-six percent said they spent too much screen time on leisure and not enough on life empowerment, i.e., using resources in the digital world to improve their lives. The paper explored the divide, its implications, and how to narrow it.

Threshold-Dependent Repression Of Spl Gene Expression By Mir156/Mir157 Controls Vegetative Phase Change In Arabidopsis Thaliana, Jia He, Mingli Xu, Matthew R. Willmann, Kevin Mccormick, Tieqiang Hu, Li Yang, Colby G. Starker, Daniel F. Voytas, Blake C. Meyers, R. Scott Poethig

Faculty Publications

Vegetative phase change is regulated by a decrease in the abundance of the miRNAs, miR156 and miR157, and the resulting increase in the expression of their targets, SQUAMOSA PROMOTER BINDING PROTEIN-LIKE (SPL) transcription factors. To determine how miR156/miR157 specify the quantitative and qualitative changes in leaf morphology that occur during vegetative phase change, we measured their abundance in successive leaves and characterized the phenotype of mutations in different MIR156 and MIR157 genes. miR156/miR157 decline rapidly between leaf 1&2 and leaf 3 and decrease more slowly after this point. The amount of miR156/miR157 in leaves 1&2 greatly exceeds the …

Which Type Of Tobacco Product Warning Imagery Is More Effective And Sustainable Over Time?, Dien Anshari, Hua-Hei Yong, Ron Borland, Kamala Swayampakala, Jim Thrasher

Faculty Publications

Objective This study examined smokers’ responses to pictorial health warnings (PHWs) with different types of imagery under natural exposure conditions.

Methods Adult smokers from online panels in Canada (n=2357), Australia (n=1671) and Mexico (n=2537) were surveyed every 4 months from 2012 to 2013. Participants were shown PHWs on packs in their respective countries and asked about: (1) noticing PHWs; (2) negative affects towards PHWs; (3) believability of PHWs; (4) PHW-stimulated discussions; and (5) quit motivation due to PHWs. Country-specific generalised estimating equation models regressed these outcomes on time (ie, survey wave), PHW imagery type (ie, symbolic representations of risk, suffering …

Fear Of Etiolation In The Age Of Professional Passion, Kathleen F. Mcconnell

Faculty Publications

Recent analysis of academia credits neoliberalism for its destabilization. Neoliberalism alone does not explain academics’ conflicted attachments to a precarious professional life or the tendency to embrace normative conceptions of passion and shun professional decline. The quarantine on decline is analogous to the exemption that J.L. Austin imposed on theatre: both deny constitutive power to certain statements and harbor a fear of queerness. Four essays published in Text & Performance Quarterly illustrate how academics quarantine professional fears and doubts. A fifth finds that the deterioration of professional accomplishments loosens normative associations to make space for other, queer relations.

A Route Less Traveled: Principals’ Perceptions Of Alternative Licensed Cte Teachers, Scott R. Bartholomew, Emma P. Bullock, Louis S. Nadelson

Faculty Publications

The shortage of teachers prepared to teach career and technical education (CTE) courses, or willing to work in certain locations (e.g. inner city, rural), has motivated the desire to explore solutions such as alternative routes to teacher licensure (ARL). Most ARL programs bypass colleges of education and provide a different approach to preparing individuals to teach, leaving many to wonder about the quality and knowledge of these teachers. Specific areas, such as CTE, have seen a large influx of ARL teachers in recent years. We sought to determine school principals’ perceptions of ARL CTE teachers. We found principal support for …

Are We Practicing What We Are Taught In Health Professions’ Education? Coproducing Health Care, Rosemary M. Caron, Ryan Joy O'Connor

Faculty Publications

Health-care providers and educators are inherently empathetic, compassionate, experienced professionals who entered their profession to assure the complementary missions of public health and health care. These missions work to ensure conditions in which people can be healthy via disease and injury prevention, health promotion, and timely, effective, coordinated care (1). The skills necessary to achieve these crucial outcomes (ie, listening to the patient and their family, exhibiting empathy, and understanding the significance of the social determinants of health, etc) are routinely taught in health professions’ education.

To highlight the necessity for these representative competencies covered throughout the course of health …

Importance Of Coverage And Quality For Impact Of Nutrition Interventions Delivered Through An Existing Health Programme In Bangladesh, Phuong Hong Nguyen, Edward A. Frongillo Jr., Tina Sanghvi, Sunny S. Kim, Silvia Alayon, Lan Mai Tran, Zeba Mahmud, Bachera Aktar, Purnima Menon

Faculty Publications

Understanding implementation of interventions is critical to illuminate if, how, and why the interventions achieve impact. Alive & Thrive integrated a nutrition intervention into an existing maternal, neonatal, and child health (MNCH) programme in Bangladesh, documenting improvements in women's micronutrient supplement intake and dietary diversity. Here, we examined how well the nutrition intervention was implemented and which elements of implementation explained intervention impact. Survey data were collected in 2015 and 2016 from frontline health workers (FLW) and households in areas randomized to nutrition‐focused MNCH (intensified interpersonal counselling, community mobilization, distribution of free micronutrient supplements, and weight‐gain monitoring) or standard MNCH …

High Male Sexual Investment As A Driver Of Extinction In Fossil Ostracods, Maria João Fernandes Martins, T. Markham Puckett, Rowan Lockwood, John P. Swaddle, Gene Hunt

Faculty Publications

Sexual selection favours traits that confer advantages in the competition for mates. In many cases, such traits are costly to produce and maintain, because the costs help to enforce the honesty of these signals and cues. Some evolutionary models predict that sexual selection also produces costs at the population level, which could limit the ability of populations to adapt to changing conditions and thus increase the risk of extinction. Other models, however, suggest that sexual selection should increase rates of adaptation and enhance the removal of deleterious mutations, thus protecting populations against extinction. Resolving the conflict between these models is …

A Computational Reconstruction Of Papio Phylogeny Using Alu Insertion Polymorphisms, Vallmer E. Jordan, Jerilyn A. Walker, Thomas O. Beckstrom, Cody J. Steely, Cullen L. Mcdaniel, Corey P. St Romain, Kim C. Worley, Jane Phillips-Conroy, Clifford J. Jolly, Jeffrey Rogers, Miriam K. Konkel, Mark A. Batzer, Jeffrey Rogers, R. Alan Harris, Muthuswamy Raveendran, Yue Liu, Shwetha Murali, Tauras P. Vilgalys, Jerilyn A. Walker, Miriam K. Konkel

Faculty Publications

© 2018 The Author(s). Background: Since the completion of the human genome project, the diversity of genome sequencing data produced for non-human primates has increased exponentially. Papio baboons are well-established biological models for studying human biology and evolution. Despite substantial interest in the evolution of Papio, the systematics of these species has been widely debated, and the evolutionary history of Papio diversity is not fully understood. Alu elements are primate-specific transposable elements with a well-documented mutation/insertion mechanism and the capacity for resolving controversial phylogenetic relationships. In this study, we conducted a whole genome analysis of Alu insertion polymorphisms unique to …

Likelihood And Cost Impact Of Engineering Change Requirements For Dod Contracts, James C. Ellis, Edward D. White, Jonathan D. Ritschel, Shawn M. Valentine, Brandon Lucas, Ian S. Cordell

Faculty Publications

Purpose: There appears to be no empirical-based method in the literature for estimating if an engineering change proposal (ECP) will occur or the dollar amount incurred. This paper aims to present an empirically based approach to address this shortfall.
Design/Methodology/Approach: Using the cost assessment data enterprise database, 533 contracts were randomly selected via a stratified sampling plan to build two regression models: one to predict the likelihood of a contract experiencing an ECP and the other to determine the expected median per cent increase in baseline contract cost if an ECP was likely. Both models adopted a stepwise approach. A …

Comparing Substance Use And Mental Health Outcomes Among Sexual Minority And Heterosexual Women In Probability And Non-Probability Samples, Laurie Drabble, Karen Trocki, Rachael Korcha, Jamie Klinger, Cindy Veldhuis, Tonda Hughes

Faculty Publications

Objective To examine similarities and differences in demographics and key substance use and mental health outcomes in a probability sample of heterosexual women and two samples of sexual minority women (SMW), one recruited using probability and the other using non-probability methods. Methods Using data from four waves of the National Alcohol Survey (NAS; n = 315 SMW; 10,523 heterosexual women) and Wave 3 of the Chicago Health and Life Experiences of Women (CHLEW; n = 688 SMW) study, we examined hazardous drinking, drug use, tobacco use, depression, and help-seeking for alcohol or other drug problems. Results Compared to SMW …

Social Recommendations For Personalized Fitness Assistance, Saumil Dharia, Magdalini Eirinaki, Vijesh Jain, Jvalant Patel, Iraklis Varlamis, Jainikkumar Vora, Rizen Yamauchi

Faculty Publications

Wearable technology allows users to monitor their activity and pursue a healthy lifestyle through the use of embedded sensors. Such wearables usually connect to a mobile application that allows them to set their profile and keep track of their goals. However, due to the relatively “high maintenance” of such applications, where a significant amount of user feedback is expected, users who are very busy, or not as self-motivated, stop using them after a while. It has been shown that accountability improves commitment to an exercise routine. In this work, we present the PRO-Fit framework, a personalized fitness assistant aiming at …

Occupying And Transcending A Provincial See: The Career Of Euthymios Malakes, Hannah Ewing

Faculty Publications

Despite a distinguished reputation as an orator and bishop in his own time, comparatively little scholarship focuses upon Euthymios Malakes, metropolitan of Neopatras during the later twelfth century. Using his extant works and contemporary sources, this article reconstructs elements of Malakes’ career in both Constantinople and Hellas. He was active in each, balancing his intellectual credentials, participation in synods, and elite connections to the capital, with immersion in more local contests. This combination allowed him to expand his pursuits and reputation beyond his minor see, in the capital and also in the province of his see.

An Evaluation Of The Classification Scheme For Adventists And Ellen White, Felipe E. Tan, Terry Dwain Robertson

Faculty Publications

Libraries at Seventh-day Adventist affiliated colleges and universities collect their denominational materials exhaustively. Many use the Library of Congress Classification Scheme (LCC). The challenge is that these exhaustive collections must fit in a classification scheme based on a general collection that does not typically hold much on this topic. LCC uses BX6151- 6155 for Seventh-day Adventists. Following the LCC notation without modification or expansion results in the proliferation of decimals, impeding both library users and staff. When a number of institutions share this same need, finding a standard notation they all can use is a mutual benefit. This paper reports …

The Natural Property Rights Straitjacket: The Takings Clause, Taxation, And Excessive Rigidity, Eric Kades

Faculty Publications

Natural property rights theories have become the primary lens through which conservative jurists and scholars view the Constitution’s main property rights provision, the Takings Clause. One of their most striking arguments is that progressive income taxation — applying higher tax rates to higher incomes — is an unconstitutional taking of wealthy taxpayers’ property. This has become part and parcel of well-established battle lines between conservative property rights advocates and their liberal counterparts. What has gone unnoticed is that the very same argument deployed against progressive taxation also deems regressive taxation — applying lower tax rates to higher incomes — an …

Making A Market For Corporate Disclosure, Kevin S. Haeberle, M. Todd Henderson

Faculty Publications

It has long been said that market forces alone will result in a problematic under-sharing of information by public companies. Since the 1930s, the main regulatory response to this market failure has come in the form of the massive mandatory-disclosure regime that sits at the foundation of modern securities law. But this regime—especially when viewed along with its speech-chilling antifraud overlay—no doubt leaves society without all the corporate information from which it would benefit. The typical fix offered to the problem has been more of the same: add to the 100-plus-page list of what firms must disclose, often based on …

How Subterranean Regulation Hinders Innovation In Assisted Reproductive Technology, Myrisha S. Lewis

Faculty Publications

Most scholars believe assisted reproductive technology is subject only to minimal regulation, especially by the federal government. This belief, I contend, is wrong. In this Article, I examine agency documents, statements by officials, and letters that the U.S. Food and Drug Administration (FDA) has sent to physicians and researchers over the past fifteen years to reveal an overlooked regulatory program. The FDA has been targeting new forms of assisted reproductive technology that involve small genetic modifications (advanced assisted reproductive technologies or AARTs) through regulatory actions that receive little public, media, or scholarly attention. I term this method of regulation “subterranean …

Editing Life: Modern Biology And Biblical Principles, Peter J. Lyons

Faculty Publications

No abstract provided.

Endothelial Cell Autonomous Role Of Akt1, Monica Y. Lee, Ana Gamez-Mendez, Jiasheng Zhang, Zhenwu Zhuang, David J. Vinyard, Jan Kraehling, Heino Velazquez, Gary W. Brudvig, Themis R. Kyriakides, Michael Simons, William C. Sessa

Faculty Publications

© 2018 American Heart Association, Inc. Objective - The importance of PI3K/Akt signaling in the vasculature has been demonstrated in several models, as global loss of Akt1 results in impaired postnatal ischemia- and VEGF-induced angiogenesis. The ubiquitous expression of Akt1, however, raises the possibility of cell-type-dependent Akt1-driven actions, thereby necessitating tissue-specific characterization. Approach and Results - Herein, we used an inducible, endothelial-specific Akt1-deleted adult mouse model (Akt1iECKO) to characterize the endothelial cell autonomous functions of Akt1 in the vascular system. Endothelial-targeted ablation of Akt1 reduces eNOS (endothelial nitric oxide synthase) phosphorylation and promotes both increased vascular contractility in isolated vessels …

Increasing Mortality In Adults With Diabetes And Low Estimated Glomerular Filtration Rate In The Absence Of Albuminuria, Holly Kramer, Robert E. Boucher, David Leehey, Linda Fried, Guo Wei, Tom Greene, Sylvia E. Rosas, Richard Cooper, Guichan Cao, Srinivasan Beddhu

Faculty Publications

OBJECTIVE Improved blood pressure control and use of renin-angiotensin-aldosterone system blockers have altered the clinical presentation or phenotype of chronic kidney disease (CKD) in U.S. adults with diabetes. These changes may influence mortality. RESEARCH DESIGN AND METHODS Data from theNationalHealth and Nutrition Examination Surveys (NHANES) 1988-2006 were used to examinemortality trends in adults with diabetes, defined as physician diagnosis, fasting glucose ≥126 mg/dL, HbA1c >6.5% (48 mmol/mol), or use of glucose-lowering medications. Mortality trends by CKD phenotype (estimated glomerular filtration rate [eGFR] and urine albumin-to-creatinine ratio [ACR] level)were obtained via linkage with the National Death Index through 31 December 2011 …

Stem Cell Factor In Combination With Granulocyte Colony-Stimulating Factor Reduces Cerebral Capillary Thrombosis In A Mouse Model Of Cadasil, Suning Ping, Xuecheng Qiu, Maria E. Gonzalez-Toledo, Xiaoyun Liu, Li Ru Zhao

Faculty Publications

Cerebral autosomal dominant arteriopathy with subcortical infarcts and leucoencephalopathy (CADASIL) is a cerebral small vascular disease caused by NOTCH3 mutation-induced vascular smooth muscle cell (VSMC) degeneration, leading to ischemic stroke and vascular dementia. Our previous study has demonstrated that repeated treatment with a combination of stem cell factor (SCF) and granulocyte colony-stimulating factor (G-CSF) reduces VSMC degeneration and cerebral endothelial cell (EC) damage and improves cognitive function in a mouse model of CADASIL (TgNotch3R90C). This study aimed to determine whether cerebral thrombosis occurs in TgNotch3R90C mice and whether repeated SCF+G-CSF treatment reduces cerebral thrombosis in TgNotch3R90C mice. Using the approaches …