Digital Commons Network^™

Oprm1 Genotype Interacts With Serotonin System Dysfunction To Predict Alcohol-Heightened Aggression In Primates, Carlos A. Driscoll, Stephen G. Lindell, Melanie L. Schwandt, Stephen J. Suomi, J. Dee Higley, Markus Heilig, Christina S. Barr

Faculty Publications

Although the notion that alcohol promotes violence is widespread, not all individuals are aggressive while intoxicated. Genetic variation could be a contributing factor to individual differences in alcohol-heightened aggression. The present study examines the effects of OPRM1C77G genotype on responses to threat in rhesus macaques under normal conditions and following alcohol administration. Prior studies have shown that a low CSF level of 5-HIAA is a trait marker for individuals prone to escalated aggression. We wanted to examine whether the predictive value for this marker on aggression was moderated by OPRM1 genotype. Animals were administered alcohol (BAC 100-200 mg%), were provoked …

Analysis Of Particle Behavior Inside The Classifier Of A Raymond Bowl Mill While Co-Milling Woody Biomass With Coal, Seyedhassan Fakourian, Andrew R. Fry, Tanner Jasperson

Faculty Publications

Woody biomass cofiring with coal at existing pulverized-coal boilers is known to be a green energy source and is a low-expense alternative for pure coal combustion. Co-milling woody biomass particles (15 wt%) with coal particles (85 wt%) before burning at a boiler is a complex problem because large woody biomass particles (>300 μm) exit the milling system along with the fine particles. A Computational Particle Fluid Dynamics (CPFD) is used in this paper to present a novel analysis about the behavior of woody biomass particles as they are mixed with coal particles inside the classifier. To meet this …

The Effects Of Music On Student Step Counts And Time In Activity In College Basketball Activity Classes, David C. Barney, Keven A. Prusak, Lindsey Brewer

Faculty Publications

Music is a powerful influence in life. We hear music at work, in the car, at the mall, and in our homes. Music has also been found to have an affect during physical activity. The purpose of this study was to examine the effects of music on physical activity rates, via pedometers, of college-aged students in basketball class. For this study 106 college-aged students participated in this study. Two classes played basketball with no music playing during game play. Two other classes played basketball with music playing during game play. It was found that the two classes that played basketball …

Hpv-Related Cancer Prevention And Control Programs At Community-Based Hiv/Aids Service Organizations: Implications For Future Engagement, Lisa T. Wigfall, Shalanda A. Bynum, Heather M. Brandt, Neethu Sebastian, Marcia G. Ory

Faculty Publications

People living with human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS) and, men who have sex with men (MSM) are disproportionately affected by genital warts and cancers caused by human papillomavirus (HPV). We assessed community-based HIV/AIDS service organizations' (ASOs) staff awareness, knowledge, attitudes, and beliefs about HPV and effective cancer prevention tools, namely HPV vaccination, Pap, and HPV tests. The potential engagement of ASO staff in future efforts to reduce the disproportionate burden of genital warts and HPV-related cancers among HIV-positive women and MSM was explored. In May-June 2016, staff were recruited from three ASOs located in the South United States Census …

Characterization Of Embyronic Stem Cell-Differentiated Fibroblasts As Mesenchymal Stem Cells With Robust Expansion Capacity And Attenuated Innate Immunity, William D'Angelo, Bohan Chen, Chandan Gurung, Yan-Lin Guo

Faculty Publications

Background: Mesenchymal stem cells (MSCs) isolated from adult tissues (Ad-MSCs) have shown great promise for use in regenerative medicine. However, their poor in vitro expansion capacity and tissue scarcity have been major limitations. In this study, we demonstrate that mouse embryonic stem cells (mESCs) can differentiate into cells with MSC properties.

Methods: Using previously established methods that characterize Ad-MSCs, we analyzed mESC-differentiated fibroblasts (mESC-FBs), including plastic adherence, clonogenic growth, MSC marker expression, tri-lineage differentiation potential, and the capacity to express immunomodulators.

Results: Although previously characterized as mESC-differentiated fibroblasts (mESC-FBs), these cells exhibit major properties of Ad-MSCs. However, …

Modification Of Asphalt Rubber With Nanoclay Towards Enhanced Storage Stability, Song-Yi Park, Minji Kang, Lynne Wilkens, Yurii Shvetsov, Brook Harmon, Nitin Shivappa, Michael Wirth, James R. Hébert, Christopher Haiman, Loïc Le Marchand, Carol Boushey

Faculty Publications

Asphalt rubber (AR), which is prepared by blending crumb rubber and bitumen, provides various advantages, including superior rutting resistance, lower road-tire noise and longer service life. However, contractors have expressed concerns regarding its poor storage stability, which in turn limits its wider application. This study aims to address the storage stability concern by incorporating nano-montmorillonite (nanoclay). Three types of nanoclay were dispersed into hot AR binder by high shear blending. The rheological properties of nanoclay-crumb rubber modifier (CRM)-modified bitumen were evaluated through Superpave performance grade (PG) tests and the storage stability was characterized by measuring the difference in softening points …

Napnap Position Statement On Immunizations, Lacey Eden, Cheryl Cairns, Karlen E. (Beth) Luthy, Mary Koslap-Petraco

Faculty Publications

The National Association of Pediatric Nurse Practitioners (NAPNAP) supports the timely and complete immunization of all infants, children, adolescents, and adults in an attempt to maximize the health and wellbeing of all people. Routine childhood immunizations prevent as many as 3 million deaths per year. In addition, 1.5 million deaths per year could be avoided if global vaccination efforts continue to improve (World Health Organization, 2017).

Understanding Dyslexia In The Context Of Developmental Language Disorders, Suzanne M. Adlof, Tiffany P. Hogan

Faculty Publications

Purpose: The purpose of this tutorial is to discuss the language basis of dyslexia in the context of developmental language disorders (DLDs). Whereas most studies have focused on the phonological skills of children with dyslexia, we bring attention to broader language skills. Method: We conducted a focused literature review on the language basis of dyslexia from historical and theoretical perspectives with a special emphasis on the relation between dyslexia and DLD and on the development of broader language skills (e.g., vocabulary, syntax, and discourse) before and after the identification of dyslexia. Results: We present clinically relevant information on the history …

Genetic And Psychological Factors Interact To Predict Physical Impairment Phenotypes Following Exercise-Induced Shoulder Injury, Paul A. Borsa, Jeffrey J. Parr, Margaret R. Wallace, Samuel S. Wu, Yunfeng Dai, Roger B. Fillingim, Steven Z. George

Faculty Publications

Background: We investigated interactions between genetic and psychological factors in predicting shoulder impairment phenotypes. We hypothesized that pro-inflammatory genes would display stronger relationships compared with pain-related genes when combined with psychological factors for predicting phenotypic changes.
Subjects and methods: Altogether, 190 participants completed a 5-day experimental protocol. An experimental shoulder injury model was used to induce physical impairment, and a priori selected genetic (pain-related, pro-inflammatory) and psychological (anxiety, depressive symptoms, pain catastrophizing, fear of pain, kinesiophobia) factors were included as predictors of interest. Impairment phenotypes were injury-induced deficits in range of motion (ROM) and strength. After controlling for age, sex, …

How Distress Tolerance Mediates The Relationship Between Posttraumatic Stress Disorder And The Interpersonal Theory Of Suicide Constructs In A U.S. Military Sample, Rachel L. Martin, Brian W. Bauer, Kathleen L. Ramsey, Bradley A. Green, Daniel Capron, Michael D. Anestis

Faculty Publications

Objectives

Despite the general suicide rate within the military being comparable to the general population when comparing peers, there are certain branches of the military that have elevated risk. Specifically, the U.S. National Guard has suicide rates that are constantly higher than other military branches and civilian peers. The National Guard are a unique military population in which they frequently transition between military and civilian life. With these unique experiences and heightened risk, military suicide prevention efforts may benefit from further research within this population. Posttraumatic stress disorder (PTSD) is another concern amongst military personnel and has been linked to …

Evidence That A Respiratory Shield In Escherichia Coli Protects A Low-Molecular-Mass Fe-Ii Pool From O2-Dependent Oxidation, Joshua D. Wofford, Naimah Bolaji, Nathaniel Dziuba, Franklin Wayne Outten, Paul A. Lindahl

Faculty Publications

Iron is critical for virtually all organisms, yet major questions remain regarding the systems' level understanding of iron in whole cells. Here, we obtained Mössbauer and EPR spectra of Escherichia coli cells prepared under different nutrient iron concentrations, carbon sources, growth phases, and O₂ concentrations to better understand their global iron content. We investigated wild-type cells and those lacking Fur, FtnA, Bfr, and Dps proteins. The coarse-grain iron content of exponentially growing cells consisted of iron-sulfur clusters, variable amounts of nonheme high-spin Fe^II species, and an unassigned residual quadrupole doublet. The iron in stationary-phase cells was dominated by …

A Simple, Sensitive And Reliable Lc-Ms/Ms Method For The Determination Of 7-Bromo-5-Chloroquinolin-8-Ol (Clbq14), A Potent And Selective Inhibitor Of Methionine Aminopeptidases: Application To Pharmacokinetic Studies, Oscar Ekpenyong, Candace Cooper, Jing Ma, Dong Liang, Omonike Olaleye, Huan Xie

Faculty Publications

CLBQ14 is an 8-hydroxyquinoline analogue that inhibits methionine aminopeptidase (MetAP), an enzyme responsible for the post-translational modification of several proteins and polypeptides. MetAP has been validated as druggable target for some infectious diseases, and its inhibitors have been investigated as potential therapeutic agents. In this study, we developed and validated a liquid chromatography tandem-mass spectrometry (LC-MS/MS) method for the quantification of CLBQ14 in solution, and in rat plasma and urine. This method was applied to the pharmacokinetic evaluation of CLBQ14 in adult male Sprague Dawley (SD) rats. Chromatographic separation was achieved using an ultra-high-performance liquid chromatography (UHPLC) system equipped with …

Aldosterone Mediated Regulation Of Epithelial Sodium Channel (Enac) Subunits In The Rat Hypothalamus, Natalie J. Mills, Kaustubh Sharma, Masudul Haque, Meagan Moore, Ryoichi Teruyama

Faculty Publications

© 2018 IBRO Current evidence suggests that the epithelial Na + channel (ENaC) in the brain plays a significant role in the development of hypertension. ENaC is present in vasopressin (VP) neurons in the hypothalamus, suggesting that ENaC in VP neurons is involved in the regulation of blood pressure. Our recent study demonstrated that high dietary salt intake caused an increase in the expression and activity of ENaC that were responsible for the more depolarized basal membrane potential in VP neurons. A known regulator of ENaC expression, the mineralocorticoid receptor (MR), is present in VP neurons, suggesting that ENaC expression …

Performance Comparison Of Low Temperature And Chemical Absorption Carbon Capture Processes In Response To Dynamic Electricity Demand And Price Profiles, Seyed Mostafa Safdarnejad, John Hedengren, Kody M. Powell

Faculty Publications

Current projections to the year 2050 reveal that fossil fuels will remain the main source of energy generation. To achieve the target limits of carbon dioxide emission, set by national and international policies, carbon capture will play a key role. Modeling and optimization of various carbon capture technologies such as pre-combustion, oxy-fuel, and post-combustion, when integrated with coal-fired power plants, have been researched extensively in literature. Research on the integration of power generation with capture technologies regarding comparisons between the different schemes in response to dynamic inputs is lacking. This work provides a comparison between a low temperature carbon capture …

Cip2a Immunosensor Comprised Of Vertically-Aligned Carbon Nanotube Interdigitated Electrodes Towards Point-Of-Care Oral Cancer Screening, Shaowei Ding, Suprem R. Das, Benjamin J. Brownlee, Kshama Parate, Taylor Davis, Loreen R. Stromberg, Edward K.L. Chan, Joseph Katz, Brian D. Iverson, Jonathan C. Claussen

Faculty Publications

Vertically aligned carbon nanotube array (VANTA) coatings have recently garnered much attention due in part to their unique material properties including light absorption, chemical inertness, and electrical conductivity. Herein we report the first use of VANTAs grown via chemical vapor deposition in a 2D interdigitated electrode (IDE) footprint with a high height-to-width aspect ratio (3:1 or 75:25 µm). The VANTA-IDE is functionalized with an antibody (Ab) specific to the human cancerous inhibitor PP2A (CIP2A)—a alivary oncoprotein that is associated with a variety of malignancies such as oral, breast, and multiple myeloma cancers. The resultant immunosensor is capable of detecting CIP2A …

A Mobile Smoking Cessation Intervention For Mexico (Vive Sin Tabaco... ¡Decídete!): Single-Arm Pilot Study, Ana Paula Cupertino, Francisco Cartujano-Barrera, Mariana Ramírez, Rosibel Rodríguez-Bolaños, James F. Thrasher, Gloria Pérez-Rubio, Ramcés Falfán-Valencia, Edward F. Ellerbeck, Luz Myriam Reynales-Shigematsu

Faculty Publications

Background: Of the 14.3 million Mexicans who smoke, only a minority take advantage of evidence-based approaches to smoking cessation. Mobile health interventions have the potential to increase the reach of effective cessation interventions in Mexico.

Objective: This study aimed to assess the feasibility and acceptability of an innovative, personalized, and interactive smoking cessation mobile intervention developed for Mexican smokers.

Methods: We recruited 40 Mexican smokers to participate in Vive sin Tabaco... ¡Decídete!, a smoking cessation program that uses a tablet-based decision support software to drive a 12-week text messaging smoking cessation program and pharmacotherapy support. Outcome measures included participant text …

Effects Of Coumaphos And Imidacloprid On Honey Bee (Hymenoptera: Apidae) Lifespan And Antioxidant Gene Regulations In Laboratory Experiments, Ales Gregorc, Mohamed Alburaki, Nicholas Rinderer, Blair Sampson, Patricia R. Knight, Shahid Karim, John Adamczyk

Faculty Publications

The main objective of this study was to test comparatively the effects of two common insecticides on honey bee Apis mellifera worker’s lifespan, food consumption, mortality, and expression of antioxidant genes. Newly emerged worker bees were exposed to organophosphate insecticide coumaphos, a neonicotinoid imidacloprid, and their mixtures. Toxicity tests were conducted along with bee midgut immunohistological TUNEL analyses. RT-qPCR assessed the regulation of 10 bee antioxidant genes linked to pesticide toxicity. We tested coumaphos at 92,600 ppb concentration, in combination with 5 and 20 ppb imidacloprid. Coumaphos induced significantly higher bee mortality, which was associated with down regulation of catalase …

Book Review: An Anxious Kind Of Mind: A True Story Of Rising Above Anxiety Disorders, By Randy Fishell.Columbia, Sc: Sbc Books, 2017, Gerald A. Klingbeil

Faculty Publications

No abstract provided.

Concentrations Of Nicotine, Nitrosamines, And Humectants In Legal And Illegal Cigarettes In Mexico, Ariela Braverman-Bronstein, James F. Thrasher, Luz Myriam Reynales-Shigematsu, Mauricio Hernández-Ávila, Tonatiuh Barrientos Gutierrez

Faculty Publications

Background: Article 10 of the World Health Organization Framework Convention on Tobacco Control states the need for industry disclosure of tobacco contents and emissions. Currently, the profiles of key tobacco compounds in legal and illegal cigarettes are largely unknown. We aimed to analyze and compare concentrations of nicotine, nitrosamines, and humectants in legal and illegal cigarettes collected from a representative sample of smokers.

Methods: Participants of the International Tobacco Control cohort provided a cigarette pack of the brand they smoked during the 2014 wave. Brands were classified as legal or illegal according to the Mexican legislation. Nicotine, nitrosamines, glycerol, propylene …

Oxygen Deprivation Influences The Survival Of Listeria Monocytogenes In Gerbils, Jillian Harris, Oindrila Paul, Si Hong Park, Sally White, Khemraj Budachetri, Daniel M. Mcclung, Jessica G. Wilson, Alicia K. Olivier, Justin A. Thornton, Paul R. Broadway, Steven C. Ricke, Janet R. Donaldson

Faculty Publications

Listeria monocytogenes is a facultative anaerobic foodborne pathogen capable of surviving harsh environments. Recent work has indicated that anaerobic conditions increase the resistance capability of certain strains to environmental stressors. The goal of the study was to conduct a preliminary study to determine whether exposure to anaerobic conditions prior to infection increases the ability to survive in vivo. Gerbils were inoculated with one of five doses of the L. monocytogenes strain F2365 by oral gavage: phosphate-buffered saline (control), 5 × 10⁶ colony forming units aerobic culture (low aerobic), 5 × 10⁸ aerobic culture (high aerobic), 5 × 10 …

Fibroblast Growth Factor 21, Adiposity, And Macronutrient Balance In A Healthy, Pregnant Population With Overweight And Obesity, Elizabeth F. Sutton, Christopher D. Morrison, Jacqueline M. Stephens, Leanne M. Redman

Faculty Publications

© 2018, © 2018 Taylor & Francis. Aim of the study: The regulation and actions of fibroblast growth factor 21 (FGF21) are responsive to energy status and macronutrient balance, and investigations of FGF21 in normal pregnancy, which could be informative for FGF21 biology, are seldom. The goal of our study was to examine FGF21 levels in a contemporary healthy, pregnant population. Methods: We phenotyped 43 women with overweight and obesity during pregnancy for weight, body composition, and fasting blood. Serum FGF21 was measured during the first and third trimesters. Placentas were collected at delivery. Results: Maternal FGF21 concentrations were positively …

Integration Of An Electrical Engineering Capstone Course With Social Justice And Global Studies, David Parent, Patricia Backer

Faculty Publications

A four course package (six units total) consisting of two general education (GE) classes and two electrical engineering capstone classes that are taught in a highly integrated manner, that not only meets university GE requirements, but also meets the new ABET criteria in which the need to address a societal need is embedded with design criteria. The prompts for the new integrated GE/capstone Assessment results are also presented, along with methods to increase student motivation for studying GE.

Examination The Impact Of Various Factors On Student Success In An Introduction To Circuit Analysis Course, David Parent

Faculty Publications

In this work in progress, several models to predict student success in a sophomore introduction to circuit analysis class were created based on prior grade point average, grade in a pre-requisite physics class, the semester the pre-requisite physics class was taken, the number of units a student was taking, the number of times a student repeated the circuits class, and the number of times a student repeated any class prior to enrollment. While all models were statistically significant, the model that included prior GPA and the grade in a pre-requisite physics was the most significant for the data collection effort. …

Automatic Authorization Of Frisks In Terry Stops For Suspicion Of Firearms Possession, Royce De R. Barondes

Faculty Publications

The recognition in Heller of an individual right to bear arms has required courts to grapple with the interaction between exercise of this right in public and Terry stops. Core questions are (i) whether reasonable suspicion a person is armed is by itself sufficient to initiate a Terry stop and (ii), if so, whether such a stop inherently authorizes an accompanying frisk. The former issue is examined in a separate forthcoming article, Royce de R. Barondes, Conditioning Exercise of Firearms Rights on Unlimited Terry Stops, 54 Idaho L. Rev. 297.

This article focuses on the second issue. Most fundamentally, insofar …

Too Ill To Be Killed: Mental And Physical Competency To Be Executed Pursuant To The Death Penalty, Linda A. Malone

Faculty Publications

Mentally ill individuals are being housed in prisons and jails throughout the country. Due to decreased funding and overpopulation of correctional facilities, individuals with pre-existing illnesses, as well as others who develop illnesses, are in severe need of mental health services and punished for their ailments through the use of solitary confinement, long prison sentences, and lack of care. The stress created by such conditions is amplified for mentally ill prisoners who are awaiting execution or the dismissal of their death row sentences. These individuals must show that they are competent to stand trial, exhibit the mental state required for …

Microbial Community Structure And Functional Potential Of Lava-Formed Gotjawal Soils In Jeju, Korea, Jong Shik Kim, Dae Shin Kim, Keun Chul Lee, Jung Sook Lee, Gary M. King, Sanghoon Kang

Faculty Publications

© 2018 Kim et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. The Gotjawal areas of Jeju Island, Korea, are comprised of unmanaged forests growing on volcanic soils. They support unique assemblages of vascular plants from both northern and southern hemispheres, but are threatened by human disturbance. The health and ecosystem function of these assemblages likely depends in part on the diversity and community structure of soil microbial communities, about which little is …

Particulate Matter Containing Environmentally Persistent Free Radicals Induces Ahrdependent Cytokine And Reactive Oxygen Species Production In Human Bronchial Epithelial Cells, Ashlyn C. Harmon, Valeria Y. Hebert, Stephania A. Cormier, Balamurugan Subramanian, James R. Reed, Wayne L. Backes, Tammy R. Dugas

Faculty Publications

© 2018 Harmon et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Particulate matter (PM) is emitted during the combustion of fuels and wastes. PM exposure exacerbates pulmonary diseases, and the mechanism may involve oxidative stress. At lower combustion temperatures such as occurs in the cool zone of a flame, aromatic compounds chemisorb to the surface of metal-oxide-containing PM, resulting in the formation of surface-stabilized environmentally persistent free radicals (EPFR). Prior studies showed …

Paper Promises For Drug Innovation, Erika Lietzan

Faculty Publications

Innovation does not stop when a new medicine is launched. Development of new uses for already approved drugs, in particular, can make profound contributions to the public health. Whether a new use is suspected during the initial premarket trials, identified through focused research after approval, or discovered serendipitously by physicians treating patients, however, it requires extensive clinical testing before it can be approved by FDA. This testing takes time and money — three to five years on average, and as much as $300 million. This Article considers the incentives that federal law offers to companies to make this investment: patent …

Class Specific Discrimination Of Volatile Organic Compounds Using A Quartz Crystal Microbalance Based Multisensor Array, Stephanie R. Vaughan, Nicholas C. Speller, Pratap Chhotaray, Kevin S. Mccarter, Noureen Siraj, Rocío L. Pérez, Yue Li, Isiah M. Warner

Faculty Publications

© 2018 Elsevier B.V. The use of quartz crystal microbalance (QCM) sensor arrays for analyses of volatile organic compounds (VOC) has attracted significant interest in recent years. In this regard, a group of uniformed materials based on organic salts (GUMBOS) has proven to be promising recognition elements in QCM based sensor arrays due to diverse properties afforded by this class of tunable materials. Herein, we examine the application of four novel phthalocyanine based GUMBOS as recognition elements for VOC sensing using a QCM based multisensor array (MSA). These synthesized GUMBOS are composed of copper (II) phthalocyaninetetrasulfonate (CuPcS4) anions coupled with …

Trans-Allelic Mutational Effects At The Peg3 Imprinted Locus, Corey L. Bretz, Joomyeong Kim

Faculty Publications

© 2018 Bretz, Kim. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. How one allele interacts with the other for the function of a gene is not well understood. In this study, we tested potential allelic interaction at the Peg3 imprinted locus with several mutant alleles targeting an Imprinting Control Region, the Peg3-DMR. According to the results, maternal deletion of the Peg3-DMR resulted in 2-fold up-regulation of two paternally expressed genes, Peg3 and Usp29. …