Digital Commons Network^™

Enhancing Mucus Flow And Clearance By Grafting Zwitterionic Hydrogel Films To Luminal Surfaces, Ryan Horne, Caleb Escudero, Morgan Ellerman, C. Allan Guymon, Marlan Hansen

Faculty Publications

Objective

To determine the effects of zwitterionic hydrogel films on mucus contact angles, flow, and stasis with respect to medical polymer surfaces, both flat and tubular.

Methods

A zwitterionic hydrogel thin film was photografted onto medical rubber surfaces and compared against non-zwitterionic hydrogel thin films and untreated surfaces to determine its impact on mucus contact angles, mucus flow on sheets and tubes, and mucus plugging.

Results

Zwitterionic and conventional hydrogel films significantly reduce the mucus contact angles and the tilt required to initiate mucus flow on sheets and in tubular systems. Preliminary experiments show that these films may also shorten …

Trans-Arg: Predicting Antibiotic Resistance Genes With A Transformer-Based Model And Pretrained Protein Language Model, Mohd Manzar Abbas, Amit Ranjan, Aixin Hou, Supratik Mukhopadhyay

Faculty Publications

Antibiotic resistance presents an emerging challenge to global health by reducing the efficacy of antibiotics administered to treat bacterial infections. Traditional approaches for detecting antibiotic resistance genes (ARGs) involve alignment-based sequence similarity techniques, which are time-consuming and resource-intensive. This signifies the necessity for developing advanced computational methods to detect ARGs early. To address this challenge, we introduce Trans-ARG, a novel multi-head attention transformer-based model designed to predict potential ARGs. Our approach leverages the pretrained ESMFold model to extract embeddings from protein sequences, capturing intricate structural and functional information. Protein sequences labelled as ARG or non-ARG were used as the dataset. …

Kg-Dta: A Knowledge Graph-Based Meta-Path Learning Framework To Predict Drug-Target Binding Affinity, Amit Ranjan, Adam Bess, Md Saiful Islam Sajol, Magesh Rajasekaran, Chris Alvin, Supratik Mukhopadhyay

Faculty Publications

Drug target affinity (DTA) prediction is essential at different phases of drug discovery and virtual drug screening. However, traditional wet lab experiments are time and resource-intensive owing to the complex interactions within the vast biological and chemical spaces. Computational methods have proven their potential to predict DTA, but none have considered the association of drugs and proteins to capture the complex interactions in the biological network between drugs and proteins. To address this, we propose a novel framework leveraging knowledge graph-based meta-path learning (KG-DTA) to enhance DTA prediction. First, we construct a weighted heterogeneous network of drugs and proteins that …

Nucleoredoxin Regulates Wnt Signaling During Pituitary Stem Cell Differentiation, Michelle L. Brinkmeier, Leonard Y M Cheung, Sean P. O'Connell, Diana K. Gutierrez, Eve C. Rhoads, Sally A. Camper, Shannon W. Davis

Faculty Publications

Nucleoredoxin (Nxn) encodes a multi-functional enzyme with oxidoreductase activity that regulates many different signaling pathways and cellular processes in a redox-dependent manner. Rare NXN mutations are reported in individuals with recessive Robinow syndrome, which involves mesomelic skeletal dysplasia, short stature, craniofacial dysmorphisms, and incompletely penetrant heart and palate defects. Here we report that Nxn is expressed in the ventral diencephalon and developing pituitary gland, and that Nxn deficient mice have pituitary dysmorphology and craniofacial abnormalities that include defects in the skull base and cleft palate. Nxn mutant mice exhibit reduced WNT signaling and reduced differentiation of pituitary stem …

Pre-Exposure Prophylaxis Uptake Among Black/African American Men Who Have Sex With Other Men In Midwestern, United States: A Systematic Review, Oluwafemi Adeagbo, Oluwaseun Abdulganiyu Badru, Prince Addo, Amber Hawkins, Monique J. Brown Ph.D., Mph, Xiaoming Li, Rima Afifi

Faculty Publications

Introduction: Black/African American men who have sex with other men (BMSM) are disproportionately affected by HIV, experience significant disparities in HIV incidence, and face significant barriers to accessing HIV treatment and care services, including pre-exposure prophylaxis (PrEP). Despite evidence of individual and structural barriers to PrEP use in the Midwest, no review has synthesized this finding to have a holistic view of PrEP uptake and barriers. This review examines patterns of, barriers to, and facilitators of PrEP uptake among BMSM in the Midwest, United States (US).

Methods: Five databases (CINAHL Plus, PUBMED, PsycINFO, SCOPUS, and Web of Science) were searched …

Byu Nano-Carbon Physics Lab, Robert Davis Dr., Richard Vanfleet Dr., Felipe Rivera Dr., David Hayes, Nick Allen, Bridget Kemper, Dan Broadbent

Faculty Publications

BYU Nano-Carbon Physics Lab

Started in 2003 by Physics Professors Robert Davis and Richard Vanfleet, who received the BYU Technology Transfer Award in 2024.

Over 81 undergraduate and 21 graduate student projects in the lab have advanced carbon nanotube (CNT) research.

Applications of research from the lab have resulted in over 30 patents, many of which have been licensed to companies for use in the world.

This display showcases highlights of work done in the lab.

Alcohol Use Disorder Medication Coverage And Utilization Management In Medicaid Managed Care Plans, Maureen T. Stewart, Sage R. Feltus, Christina M. Andrews Ph.D., Andrea Acevedo, Cindy Parks Thomas, Jeffrey Bratberg, Constance M. Horgan, Dominic Hodgkin, Rachel Sayko Adams

Faculty Publications

Importance: Evidence-based, patient-centered treatment for alcohol use disorder (AUD) can include pharmacotherapy with naltrexone, acamprosate, or disulfiram; however, these medications are rarely used. Medicaid managed care plans (MCPs) manage health services for nearly 80% of Medicaid enrollees and are the largest payer for addiction treatment services. Little is known about Medicaid MCP policies for AUD medications. Objectives: To describe Medicaid MCPs' coverage and management of acamprosate, naltrexone, and disulfiram for AUD and examine associations of plan characteristics and state policies with medication coverage. Design, Setting, and Participants: In this cross-sectional study, a content analysis was performed of 2021 insurance benefit …

Older Adults’ Health, Ethnicity, And Daily Life, Hyunsook Kang, Mihae Bae

Faculty Publications

Abstract

This study examines the relationship between ethnicity and daily functional disabilities among older adults, focusing on Activities of Daily Living (ADLs) and Instrumental Activities of Daily Living (IADLs). The analysis uses data from the 2020 National Social Life, Health, and Aging Project (NSHAP) survey, which included a sample of individuals aged 57-85 (n=3,005). Respondents provided information on their demographic background (e.g., income, gender, race, age, health, retirement, and marital status) and socioeconomic characteristics through telephone interviews.

The study hypothesized that ethnic differences would be evident in perceived difficulties with ADLs and IADLs in later life. To assess these relationships, …

The Lumberman, The "General," The Watchman, And The Comeback Queen: The Afterlife Of Slavery In The Bayou City From 1861 To The Present, Karen Kossie-Chernyshev

Faculty Publications

Using oral history and genealogical research, this essay examines the historical ties of a lifetime resident of Houston's historic Fifth Ward community to selected members of William Marsh Rice’s family from the period of slavery to freedom. This narrative reaffirms the role that oral history plays in our understanding of the afterlife of urban slavery in Houston, Texas, the nation’s 4th-largest city.

Modelling The Effects Of Vegetation Distribution And Density On Hydrological Connectivity And Water Age In A River Delta, Madoche Jean Louis, Matthew Hiatt

Faculty Publications

Water transport timescales (WTTs) quantify how long it takes for water to travel through or remain in a system and are often cast as indicators of ecosystem function and health. Such timescales are known to be affected by vegetation in various environments. We quantify the impact of floodplain vegetation on WTTs within the Wax Lake Delta (WLD), a river delta system in Louisiana, USA, using a high-resolution Delft3D Flexible Mesh (DFM) model incorporating vegetation-induced flow resistance. We show that increased vegetation density leads to extended WTTs within vegetated sections of WLD while fostering flow localization and accelerating transport within distributary …

A Practical Guide For Using The Rps Negotiation And Mediation Coach, John Lande

Faculty Publications

This two-page guide introduces the RPS Negotiation and Mediation Coach, an AI-powered tool grounded in Real Practice Systems (RPS) theory. It explains who can use RPS Coach, how it supports good decision-making, and the range of tasks it can perform. It is designed for attorneys, mediators, parties, ADR program administrators, educators, and students to improve the quality of dispute resolution practice, program design, and legal education. Practitioners and parties can use it to prepare for, participate in, and reflect on negotiation and mediation. Faculty can use it to develop syllabi, assignments, and simulations. Users can explore ideas, generate drafts, and …

Hd-Tacs Over The Left Frontal Aslant Tract Entrains Theta Activity Associated With Speech Motor Control, Karim Johari, Fatemeh Tabari

Faculty Publications

Transient disruption or permanent damage to the left Frontal Aslant Tract (FAT) is associated with deficits in speech production. The present study examined the application of theta (4 Hz) high-definition transcranial alternating current stimulation (HD-tACS) over the left SMA and IFG –as a part of FAT- as a potential multisite protocol to modulate neural and behavioral correlates of speech motor control. Twenty-one young adults participated in three counterbalanced sessions in which they received in-phase, anti-phase, and sham theta HD-tACS. In each session, 4 Hz stimulation was applied over the left IFG and SMA, and subsequently EEG data was recorded while …

Modulators Of Energy Expenditure Accuracy In Adults With Overweight Or Obesity: E-Mechanic Secondary Analyses, Rachel Matthews, Christoph Höchsmann, Melissa L. Erickson, James L. Dorling, Guillaume Spielmann, Neil M. Johannsen, Timothy S. Church, Corby K. Martin

Faculty Publications

Purpose American College of Sports Medicine (ACSM) metabolic equations are used to estimate energy expenditure (EE) of physical activity and prescribe aerobic exercise to meet EE requirements. Limited evidence supports their accuracy in sedentary adults with overweight or obesity during controlled exercise interventions. The purpose of this study was to compare EE estimated by the ACSM walking equation versus EE measured by indirect calorimetry during a 24-wk aerobic exercise intervention, and identify potential modulators for their accuracy. Methods Data from the exercising groups (8 or 20 kcal·kg body weight-1·wk-1) of the E-MECHANIC study were utilized in this ancillary analysis (N …

Social-Ecological Correlates Of Social Well-Being In Transgender And Gender Diverse Adults In The Usa: Implications For Policy, Theory, And Research, Robert J. Cramer, Andréa R. Kaniuka, Raymond P. Tucker, Brenda Hanson, Richard C. Fording, Lee Robertson, Casey Mesaeh, Sasha Zabelski, Thomas Joiner

Faculty Publications

Introduction: Emerging transgender and gender diverse (TGD) health models focus on social well-being. The present study contributes to this movement through investigation of hate crime statutes, state-level political and anti-TGD attitudes, and multiple marginalized identities as correlates of social well-being (i.e., outness, community connection, and workplace and familial support). Methods: The current study merged data from three sources: (a) the 2015 United States Transgender Survey (USTS), (b) the 2014 and 2018 Cooperative Congressional Election Studies (CCES), and (c) the 2018 Anti-Defamation League’s (ADL) Hate Crime Map. Bivariate (e.g., chi-square) and regression analyses were used to identify correlates of social well-being …

From The Mountains To The Beach: Water Purification Ecosystem Services And Recreational Beach Use In Puerto Rico, Maya Corridore, Rebeca De Jesús Crespo, Mariam Valladares-Castellanos, Thomas Douthat

Faculty Publications

Recreational beach use is important for coastal economies and is influenced by water clarity, a trait that may be maintained by water purification ecosystem services (ESs). However, few studies have addressed these linkages. In this study, we ask the following questions: (1) Do watershed-scale water purification ecosystem services influence coastal water quality? (2) Does coastal water quality help explain beach visitation rates? To address these questions, we focused on Puerto Rico (PR), where coastal tourism has economic and cultural importance. We estimated water purification ESs using the Integrated Valuation of Ecosystem Services and Tradeoffs (InVEST), coastal water quality using long-term …

Post-Wildfire Mobilization Of Organic Carbon, Travis Numan, Srinidhi Lokesh, Abrar Shahriar, Anil Timilsina, Myron L. Lard, Justin Clark, Yasaman Raeofy, Qian Zhao, Simon R. Poulson, Paul S. Verburg, Jocelyn A. Richardson, Robert L. Cook, Vera Samburova, Yu Yang

Faculty Publications

Wildfires significantly alter watershed functions, particularly the mobilization of organic carbon (OC). This study investigated OC mobility and the physicochemical characteristics of wildfire-impacted soils and ashes from the northern California and Nevada fires (Dixie, Beckworth, Caldor). Organic carbon in wildfire-derived ashes (9.2–57.3 mg/g) generally exceeded levels in the background soils (4.3–24.4 mg/g), except at the Dixie fire sites. The mobile OC fraction varied from 0.0093 to 0.029 in ashes and 0.010 to 0.065 in soils, though no consistent trend was observed between the ashes and soils. Notably, the ash samples displayed lower OC mobility compared with the soils beneath them. …

Church Leaders’ Health Behaviors And Program Implementation In The Faith, Activity, And Nutrition Program In The United States, Kelsey R. Day, Sara Wilcox Phd, Lindsay Decker, John Bernhart Ph.D., Mph, Ches, Meghan Baruth, Andrew T. Kaczynski Ph.D., Christine A. Pellegrini Ph.D.

Faculty Publications

Objectives: Church leaders are important to the success of faith-based health promotion interventions through the role modeling of health behaviors. However, clergy may be at a higher risk of chronic disease than their congregants and their health is understudied. This study examined church leaders’ health-related behaviors, differences in health behaviors by socio-demographic characteristics, and associations between health behaviors and church-level implementation of an ecological intervention. Methods: Pastors (n = 93) and church coordinators (n = 92) reported body mass index (BMI), self-rated health, fruit and vegetable consumption (F&V), and physical activity (PA) at baseline and 12 months post-training in the …

Comparing The Restoration Effect And Stress Recovery In Real And Virtual Environments With A Green Wall, Alireza Sedghikhanshir, Yan Chen, Yimin Zhu, Melissa R. Beck, Amirhosein Jafari

Faculty Publications

Biophilic design, incorporating natural elements, is known to enhance stress recovery. Immersive virtual environments (IVEs) are increasingly utilized for biophilic design validation and research, but their efficacy in replicating the restorative effects of real environments remains uncertain. Varying responses to virtual settings suggest that specific design factors may affect their effectiveness. This study provides a novel comparison of the stress recovery and restoration effect between real and virtual green walls in a controlled climate chamber. Sixty-three participants were exposed to either a real or virtual green wall for seven minutes after a 5 min stressor task. Physiological stress responses, including …

Time-Series Data-Driven Pm2.5 Forecasting: From Theoretical Framework To Empirical Analysis, Chunlai Wu, Ruiyang Wang, Siyu Lu, Jiawei Tian, Lirong Yin, Lei Wang, Wenfeng Zheng

Faculty Publications

PM2.5 in air pollution poses a significant threat to public health and the ecological environment. There is an urgent need to develop accurate PM2.5 prediction models to support decision-making and reduce risks. This review comprehensively explores the progress of PM2.5 concentration prediction, covering bibliometric trends, time series data characteristics, deep learning applications, and future development directions. This article obtained data on 2327 journal articles published from 2014 to 2024 from the WOS database. Bibliometric analysis shows that research output is growing rapidly, with China and the United States playing a leading role, and recent research is increasingly focusing on data-driven …

Religious Nationalism: Narendra Modi’S 2019 Election Victory Speech, Nihar Sreepada

Faculty Publications

The ideology of nationalism is permeating and ascending across societies, eventually manifesting materially in several nations across the world. In this essay, I analyze the religious manifestation of nationalism within the context of India’s Hindu nationalism. I argue that Modi, in his 2019 election victory speech, constructs a grand narrative of Hindu nationalistic unification by positioning himself as a Hindu sanyasi (ascetic) and by alluding to Hindu mythologies. First, I present the historical context of India’s Hindu nationalism (Hindutva). Second, I explicate the formation of an ideological discourse through Kenneth Burke’s focus on identification and the constitutive rhetoric of calling …

Rural–Urban Differences In Substance Use During Pregnancy, Emma Kathryn Boswell, Olivia M. Hinds, Cassie Odahowski Phd, Mph, Elizabeth L. Crouch, Peiyin Hung Ph.D, Christina M. Andrews Ph.D.

Faculty Publications

Purpose: Drug overdoses are now a leading cause of pregnancy-related deaths in the United States. Despite evidence of rural–urban disparities in substance use, there has not yet been a nationally representative examination of rural–urban differences in perinatal substance use. This study provides a comprehensive examination of rural–urban disparities in perinatal substance use. Methods: This study uses cross-sectional data to examine 3499 pregnant women from the 2015–2019 National Survey on Drug Use and Health (NSDUH). Rural (nonmetro)–urban (metro) differences in past-month tobacco use, alcohol use, binge drinking, illicit drug use, and marijuana use were examined using Rao–Scott chi-square tests and multivariable …

Increasing A-Type Co32− Substitution Decreases The Modulus Of Apatite Nanocrystals, Stephanie Wong, Abigail Eaton, Christina Krywka, Arun Nair, Christophe Drouet, Alix Deymier

Faculty Publications

Biological apatite mineral is highly substituted with carbonate (CO₃²⁻). CO₃²⁻ can exchange for either phosphate, known as B-type, or hydroxyl groups, known as A-type. Although the former has been extensively studied, A-type CO₃²⁻ substituted apatites are poorly understood. Therefore, A-type CO₃²⁻ apatites with biologically relevant levels of CO32− (1.7–5.8 wt%) were prepared and characterized. The addition of A-type CO₃²⁻ into the apatite structure caused the predicted expansion of the a-axis and contraction of the c-axis in the unit cell. This was accompanied by a significant modification in the atomic …

Modifiable And Non-Modifiable Risk Factors For Dementia Among Non-Hispanic White And Black Populations Aged 50-64 In The United States, 2006-2016, Jingkai Wei, Matthew C. Lohman Ph.D., Monique J. Brown, James W. Hardin, Chih-Hsiang Yang, Anwar T. Nerchant, Daniela B. Friedman

Faculty Publications

Background and Objectives

Research Design and Methods

Adverse Childhood Experiences, Resilience, And Syringe Services Program Attendance Among Persons Who Inject Drugs In Northeast Georgia, Usa: A Mediation Analysis, Mohammad Rifat Haider, Samantha Clinton, Monique J. Brown, Nathan B. Hansen

Faculty Publications

Background: Syringe services programs (SSP) are evidence-based venues offering harm reduction services to persons who inject drugs (PWID), such as sterile syringes, STI/HIV testing, and linkage to care to decrease drug use-related morbidities and mortalities. Adverse childhood experiences (ACEs) have been linked with reduced resilience, while increased resilience can help PWID attend SSPs. This study examined the potential mediating role of resilience between ACEs and SSP attendance among PWID.

Methods: Data were collected from adult HIV-negative PWID in northeast Georgia, between February-December 2023 (N = 173). Data were collected on SSP attendance (Yes vs. No), resilience, and ACEs. Covariates included …

Geographic Disparities In Unpaid Caregiving, Emma Kathryn Boswell, Monique J. Brown Ph.D., Mph, Lorie Donelle Phd, Rn, Fcan, Nicholas Yell, Taryn Farrell, Peiyin Hung Ph.D., Elizabeth Crouch Ph.D.

Faculty Publications

Purpose: An updated, nationally representative examination of rural–urban differences in the experiences, health, and well-being of caregivers is needed; previous research on this topic uses older data or has limited generalizability. This study examines rural–urban differences in the characteristics, experiences, and health of caregivers. Methods: The 2021–2022 Behavioral Risk Factor Surveillance System (n = 44,274 unpaid caregivers) was used, with rurality defined according to the 2013 National Center for Health Statistics (NCHS) Urban-Rural Classification Scheme. Chi-square tests compared rural–urban differences in these caregivers’ characteristics, including demographic factors, caregiving intensity (e.g., weekly hours spent caregiving, reason for caregiving, past-month ADL/IADL assistance), …

A Wounded Healer: Childhood Trauma’S Eeffects On Pastoral Ministry, David Sedlacek, René Drumm

Faculty Publications

No abstract provided.

Race, The Academy, And The Constitution Of The War On Drugs, Bennett Capers, Jeffrey Bellin

Faculty Publications

The war on drugs is widely viewed as a policy failure. Despite massive government intrusions on personal liberty, drug addiction, overdoses, and drug-related violence have only increased since the war was declared in 1971. David Pozen’s new book, The Constitution of the War on Drugs, reveals a constitutional failure as well. Pozen chronicles a host of constitutional arguments that American litigants deployed to protect a “right” to use drugs with surprising, if fleeting, success. Pozen asks what might have been, exploring why the courts backtracked and effectively removed the Constitution as a meaningful obstacle to drug prohibitions.

This Review …

Is Bullying Associated With Health Risk And Quality Of Life Behaviors In Adolescents?, Ana Beatriz Pacífico, Eliane Denise Araújo Bacil, Thiago Silva Piola, Michael Pereira Da Silva, Fabio Fontana, Jhonatan Gritten Campos, Ademar Avelar, Wagner De Campos

Faculty Publications

This study assessed the practice of bullying, health risk behavior and quality of life in adolescent boys and girls from the city of Maringá, Paraná. A representative sample of 1,020 adolescents participated in the study to assess the association between bullying, health-risk behavior, and quality of life factors through self-reported questionnaires. Odds ratios with 95% confidence intervals (95%CI) were obtained using both crude and adjusted binary and ordinal logistic regression, with a significance level of p< 0.05. Male bullying perpetrators were 2.2 (95%CI=1.4-3.4) and 2.0 (95%CI=1.2-3.2) times more likely to consume alcohol and engage in physical activity compared to non-bullying males. Female bullying perpetrators were 2.1 (95%CI=1.3-3.5), 3.6 (95%CI=1.3-10.1), 1.8 (95%CI=1.1-2.9), and 2.7 (95%CI=1.1-6.3) times more likely to smoke, use illicit drugs, be addicted to smartphones, and have poorer sleep quality. These girls also had a 60% higher chance of having a worse perception of quality of life, respectively, compared to non-bullying females. The conclusion drawn is that bullying may be associated with health risk behaviors for both boys and girls.

Potential Of Individual Upper-Limb Muscles To Contribute To Postural Tremor: Simulations From Neural Drive To Joint Rotation, Spencer A. Baker, Landon J. Beutler, Daniel B. Free, Dario Farina, Steven Knight Charles

Faculty Publications

Background: It is unclear which muscles contribute most to tremor and should therefore be targeted by tremor suppression methods. Previous studies used mathematical models to investigate how upper-limb biomechanics affect muscles’ potential to generate tremor. These investigations yielded principles, but the models included at most only 15 muscles. Here we expand previous models to include 50 upper-limb muscles, simulate tremor propagation, and test the validity of the previously postulated principles. Methods: Tremor propagation was characterized using the gains between tremorogenic neural drive to the 50 muscles (inputs) and tremulous joint rotations in the 7 joint degreesof- freedom (DOF) from shoulder …

Legal Residency Status And Its Relationship With Health Indicators Among Syrian Refugees In Lebanon: A Nested Cross-Sectional Study, Marie-Elizabeth Ragi, Hala Ghattas Ph.D., Berthe Abi Zeid, Hazar Shamas, Noura Joseph El Salibi, Sawsan Abdulrahim, Jocelyn Dejong, Stephen J. Mccall, The Caep Study Group

Faculty Publications

Background Failure to possess or renew legal residency permits increases the burden on a vulnerable refugee population. It risks detention or deportation, and hinders access to basic services including healthcare. This study aimed to examine the association between legal residency status and health of Syrian refugees living in Lebanon.

Methods Data were from two independent nested cross-sectional studies collected in 2022 through telephone surveys. In the first study, all Syrian refugees aged 50 years or older from households that received humanitarian assistance were invited to participate. The second included all adult Syrian refugees residing in a suburb of Beirut. The …