Digital Commons Network^™

Patient With Questions About Cancer Risk, Deborah O. Himes, Jennie Vagher

Faculty Publications

Primary care nurse practitioners routinely care for patients with personal or family histories of cancer. Approximately 5% to 10% of all cancers are related to hereditary cancer syndromes (HCSs), which cause an increased risk for developing more cancers and cancers at earlier ages than the general population. Nurse practitioners in primary care must become comfortable with identifying patients at risk for HCSs. Ordering genetic tests can be a challenge because the number of genetic tests available is growing at a rapid pace. This case highlights a woman who survived breast cancer at age 25 and basal cell carcinoma at age …

Impact Of Reappraisal Of Fluoroquinolone Minimum Inhibitory Concentration Susceptibility Breakpoints In Gram-Negative Bloodstream Isolates, Stephanie C. Shealy, Matthew M. Brigmon, Julie Ann Justo, P Brandon Bookstaver, Joseph Kohn, Majdi N. Al-Hasan

Faculty Publications

The Clinical Laboratory Standards Institute lowered the fluoroquinolone minimum inhibitory concentration (MIC) susceptibility breakpoints for and glucose non-fermenting Gram-negative bacilli in January 2019. This retrospective cohort study describes the impact of this reappraisal on ciprofloxacin susceptibility overall and in patients with risk factors for antimicrobial resistance. Gram-negative bloodstream isolates collected from hospitalized adults at Prisma Health-Midlands hospitals in South Carolina, USA, from January 2010 to December 2014 were included. Matched pairs mean difference (MD) with 95% confidence intervals (CI) were calculated to examine the change in ciprofloxacin susceptibility after MIC breakpoint reappraisal. Susceptibility of to ciprofloxacin declined by 5.2% (95% …

Everyday Communication Challenges In Aphasia: Descriptions Of Experiences And Coping Strategies, Tyson G. Harmon

Faculty Publications

Background: Everyday communication often occurs in situations that pose high attentional and social demands. People with aphasia have reported perceiving greater challenge communicating in these situations, but more specific information about these challenges could help clinicians and researchers work toward more meaningful intervention outcomes and increased life participation.

Aims: To explore the everyday communication experiences of people with aphasia based on their own perspectives and to identify how they report coping with everyday communication challenges.

Method: Twenty-one participants with mild or moderate aphasia completed semi-structured interviews that immediately followed the experimental arm of a larger project. Interview questions solicited descriptions …

Spared Perception Of The Structure Of Scenes After Hippocampal Damage, Zhisen J. Urgolites, Ramona O. Hopkins, Larry R. Squire

Faculty Publications

To explore whether the hippocampus might be important for certain spatial operations in addition to its well-known role in memory, we administered two tasks in which participants judged whether objects embedded in scenes or whether scenes themselves could exist in 3-D space. Patients with damage limited to the hippocampus performed as well as controls in both tasks. A patient with large medial-temporal lobe lesions had a bias to judge objects in scenes and scenes themselves as possible, performing well with possible stimuli but poorly with impossible stimuli in both tasks. All patients were markedly impaired at remembering the tasks. The …

Episodes From The History Of American-Soviet Cultural Relations: Stanford Slavic Studies, Volume 5 (1992), Lazar Fleishman, Ronald D. Leblanc (Translator)

Faculty Publications

Appearing here for the first time in an English-language translation are four of the illuminating essays, written by the renowned Pasternak scholar, Professor Lazar Fleishman, that are contained in his book, From the History of Russian and Soviet Culture: Documents from the Hoover Institution (Stanford Slavic Studies, Volume 5), published in 1992. These four essays appear in the section of his book, titled “Episodes from the History of American-Soviet Cultural Relations,” which includes the following: (1) “Introduction,” an introductory essay that provides background on the American journalist Joseph Freeman, (2) “Joseph Freeman and Boris Pilnyak,” an essay that explores Freeman’s …

Establishment Of A Reliable Change Index For The Gad-7, Thomas Bischoff, Shayne R. Anderson, Joy Heafner, Rachel Tambling

Faculty Publications

Aim: It is increasingly important for mental healthcare providers and researchers to reliably assess client change, particularly with common presenting problems such as anxiety. The current study addresses this need by establishing a Reliable Change Index of 6 points for the GAD-7.

Method: Sample size included 116 online community participants using Amazon’s Mechanical Turk (MTurk) and archival data for 332 clinical participants. Participants completed measures of the GAD-7 and the MDI in 2 rounds. Using previously established cutoff scores and Jacobson and Truax’s (1991) method, we establish a Reliable Change Index which, when applied to 2 administrations of the GAD-7, …

Spatial Distribution Of Lycorma Delicatula (Hemiptera: Fulgoridae) Egg Masses On Tree-Of-Heaven, Black Walnut, And Siberian Elm In North America, Houping Liu, Richard J. Hartlieb, Timothy Schowalter

Faculty Publications

The spatial distribution of Lycorma delicatula (White) egg masses on three species of trees were studied in Pennsylvania. Five tree-of-heaven, five black walnut, and one Siberian elm trees were felled in early spring 2019 to sample for egg masses. Each egg mass was marked for its cardinal direction, position in the tree, height above ground, and spread from the bole. A total of 214 egg masses were found on tree-of-heaven and black walnut, with 38.3, 29.4, 22.0, and 10.3% on the north, west, south, and east quadrant, respectively. No significant difference in cardinal direction was found for either species. Equal …

Associations Between Food Insecurity And Psychotropic Medication Use Among Women Living With Hiv In The United States, Henry J. Whittle, William R. Wolfe, Lila A. Sheira, Edward A. Frongillo Jr., Kartika Palar, Daniel Merenstein, Tracey E. Wilson, Adebola Adedimeji, Mardge H. Cohen, Eryka L. Wentz, Phyllis C. Tien, Sheri D. Weiser

Faculty Publications

AIMS: Psychotropic prescription rates continue to increase in the United States (USA). Few studies have investigated whether social-structural factors may play a role in psychotropic medication use independent of mental illness. Food insecurity is prevalent among people living with HIV in the USA and has been associated with poor mental health. We investigated whether food insecurity was associated with psychotropic medication use independent of the symptoms of depression and anxiety among women living with HIV in the USA. METHODS: We used cross-sectional data from the Women's Interagency HIV Study (WIHS), a nationwide cohort study. Food security (FS) was the primary …

Shinylearner: A Containerized Benchmarking Tool For Machine-Learning Classification Of Tabular Data, Stephen Piccolo, Terry J. Lee, Erica Suh, Kimball Hill

Faculty Publications

Background: Classification algorithms assign observations to groups based on patterns in data. The machine-learning community have developed myriad classification algorithms, which are used in diverse life science research domains. Algorithm choice can affect classification accuracy dramatically, so it is crucial that researchers optimize the choice of which algorithm(s) to apply in a given research domain on the basis of empirical evidence. In benchmark studies, multiple algorithms are applied to multiple datasets, and the researcher examines overall trends. In addition, the researcher may evaluate multiple hyperparameter combinations for each algorithm and use feature selection to reduce data dimensionality. Although software implementations …

Hpv Knowledge, Attitudes, And Vaccination Among Hispanic/Latino College Students In The Usa, Itzel Corral Gonzalez, Wei-Chen Tung, Ho-Jui Tung, Wing Lam Tock

Faculty Publications

This study evaluated Human Papillomavirus-related knowledge and attitudes, vaccination practices, and explored associated factors among Hispanic/Latino college students in the United States of America. Using a self-administered survey, a descriptive, cross-sectional quantitative study was conducted in 2018 at colleges and universities in the United States of America. Our results indicate that Hispanic/Latino college students had a low level of HPV-related knowledge, a moderately positive attitude, and a moderate rate of HPV vaccination. Students who were in a health-related major, married/divorced, and had health insurance had greater knowledge and more positive attitudes towards HPV and its vaccines. This study is important …

Advancing Evidence Synthesis From Effectiveness To Implementation: Integration Of Implementation Measures Into Evidence Reviews, Aaron Tierney, Marie Haverfield, Mark Mcgovern, Donna Zulman

Faculty Publications

BackgroundIn order to close the gap between discoveries that could improve health, and widespread impact on routine health care practice, there is a need for greater attention to the factors that influence dissemination and implementation of evidence-based practices. Evidence synthesis projects (e.g., systematic reviews) could contribute to this effort by collecting and synthesizing data relevant to dissemination and implementation. Such an advance would facilitate the spread of high-value, effective, and sustainable interventions.ObjectiveThe objective of this paper is to evaluate the feasibility of extracting factors related to implementation during evidence synthesis in order to enhance the replicability of successes of studies …

Anomalous Oceanic Conditions In The Central And Eastern North Pacific Ocean During The 2014 Hurricane Season And Relationships To Three Major Hurricanes, Victoria L. Ford, Nan D. Walker, Iam Fei Pun

Faculty Publications

The 2014 Northeast Pacific hurricane season was highly active, with above-average intensity and frequency events, and a rare landfalling Hawaiian hurricane. We show that the anomalous northern extent of sea surface temperatures and anomalous vertical extent of upper ocean heat content above 26 °C throughout the Northeast and Central Pacific Ocean may have influenced three long-lived tropical cyclones in July and August. Using a variety of satellite-observed and-derived products, we assess genesis conditions, along-track intensity, and basin-wide anomalous upper ocean heat content during Hurricanes Genevieve, Iselle, and Julio. The anomalously northern surface position of the 26 °C isotherm beyond 30° …

Advances In The Neurophysiology Of Magnocellular Neuroendocrine Cells, Jeffrey G. Tasker, Masha Prager-Khoutorsky, Ryoichi Teruyama, José R. Lemos, William E. Amstrong

Faculty Publications

© 2020 British Society for Neuroendocrinology Hypothalamic magnocellular neuroendocrine cells have unique electrical properties and a remarkable capacity for morphological and synaptic plasticity. Their large somatic size, their relatively uniform and dense clustering in the supraoptic and paraventricular nuclei, and their large axon terminals in the neurohypophysis make them an attractive target for direct electrophysiological interrogation. Here, we provide a brief review of significant recent findings in the neuroplasticity and neurophysiological properties of these neurones that were presented at the symposium “Electrophysiology of Magnocellular Neurons” during the 13th World Congress on Neurohypophysial Hormones in Ein Gedi, Israel in April 2019. …

Food Safety Risk Information-Seeking Intention Of Wechat Users In China, Zhaohui Yang, Krishna P. Paudel, Xiaowei Wen, Sangluo Sun, Yong Wang

Faculty Publications

© 2020 by the authors. Licensee MDPI, Basel, Switzerland. Consumers’ food safety risk information-seeking behavior plays a vital role in improving their food quality and safety awareness and preventing food safety risks. Based on the Risk Information Seeking and Processing Model (RISP), this paper empirically analyzes the food safety risk information-seeking intention of consumers in WeChat and influencing factors under the impact of food safety incidents. We use data from 774 WeChat users and apply the Structural Equation Modeling (SEM) approach. We also conduct multigroup analysis with demographic characteristics as moderating variables. The results demonstrated that: (1) Risk perception (p …

Addressing The Class Claim Conundrum With Online Dispute Resolution, Amy J. Schmitz

Faculty Publications

Consumers with similar claims in the United States (U.S.) often join forces to launch representative, or "class", actions. This allows them to obtain remedies with little cost and effort and serves a "private attorney general" function by bringing light to purchase problems that public enforcement offices may not have the resources to address. This is especially important for lower dollar claims that are too costly for each consumer to pursue individually.

Nonetheless, some have criticized class actions in the U.S. for forcing settlements and padding the pockets of lawyers, while leaving consumers with minimal pay outs. At the same time, …

Efficacy Of Entomopathogenic Nematodes Against The Sugarbeet Wireworm, Limonius Californicus (Mannerheim) (Coleoptera: Elateridae), Ramandeep Kaur Sandhi, David Shapiro-Ilan, Anamika Sharma, Gadi V.P. Reddy

Faculty Publications

Wireworms, the larval stage of click beetles (Coleoptera: Elateridae), are economically important soil-dwelling pests that attack many field crops worldwide. Wireworms have become a serious threat to spring wheat in the Northern Great Plains because of lack of effective control measures, creating a need for alternative control methods such as biological control with entomopathogenic nematodes (EPNs). A laboratory bioassay was used to test ten EPN strains and identify infective EPN strains against the sugarbeet wireworm, Limonius californicus (Mannerheim) (Coleoptera: Elateridae). Steinernema carpocapsae (Weiser) (All and Cxrd strains) and S. riobrave Cabanillas, Poinar, and Raulston (355 and 7–12 strains) killed 60–70% …

Nucleolar Stress In Drosophila Neuroblasts, A Model For Human Ribosomopathies, Sonu Shrestha Baral, Molly E. Lieux, Patrick J. Dimario

Faculty Publications

Different stem cells or progenitor cells display variable threshold requirements for functional ribosomes. This is particularly true for several human ribosomopathies in which select embryonic neural crest cells or adult bone marrow stem cells, but not others, show lethality due to failures in ribosome biogenesis or function (now known as nucleolar stress). To determine if various Drosophila neuroblasts display differential sensitivities to nucleolar stress, we used CRISPR-Cas9 to disrupt the Nopp140 gene that encodes two splice variant ribosome biogenesis factors (RBFs). Disruption of Nopp140 induced nucleolar stress that arrested larvae in the second instar stage. While the majority of larval …

Decarbonization In Democracy, Shelley Welton

Faculty Publications

Conventional wisdom holds that democracy is structurally ill-equipped to confront climate change. As the story goes, because each of us tends to dismiss consequences that befall people in other places and in future times, “the people” cannot be trusted to craft adequate decarbonization policies, designed to reduce present-day, domestic carbon emissions. Accordingly, U.S. climate change policy has focused on technocratic fixes that operate predominantly through executive action to escape democratic politics — with vanishingly little to show for it after a change in presidential administration.

To help craft a more durable U.S. climate change strategy, this Article scrutinizes the purported …

Covid-19 And Conflicts: The Health Of Peace Processes During A Pandemic, Lisa K. Dicker, C. Danae Paterson

Faculty Publications

(Excerpt)

This Article reviews the status of selected contemporary peace processes in the early stages of the COVID-19 outbreak and explores some of the initial effects that the pandemic has had on those processes. The Article first provides an overview of the 20th and 21st century trend toward internationalized peace processes. Then, it introduces several contemporary mediation efforts that were ongoing at the onset of the pandemic and examines the early impacts of COVID-19 on those peace processes. In so doing, the Article identifies instances where actors have exploited the pandemic and peace processes where momentum has shrunk under COVID-19. …

The Impact Of Innovative Executive Servant Leadership On Organizational Citizenship, And Organizational Cynicism, Jerry L. Chi, Grace Chi, Nile M. Khanfar, Gabriel Gao, Belal A. Kaifi

Faculty Publications

Have you ever wondered how your employees complained to their friends about how things happened in your organization? The most challenging part for Servant Leadership is to reduce organizational cynicism and nurture organizational citizenship. The major research interest for this study was to discover whether the bottom-up servant leadership theory to “serve” first and “lead” second can be truly practiced by the president of a university and whether it is valid and effective in reducing employee’s organizational cynicism and enhancing employee’s organizational citizenship. The results showed that the goodness of fit (GFI) was good and sufficient and adequate. The null …

Keeping Ai Under Observation: Anticipated Impacts On Physicians' Standard Of Care, Iria Giuffrida, Taylor Treece

Faculty Publications

As Artificial Intelligence (AI) tools become increasingly present across industries, concerns have started to emerge as to their impact on professional liability. Specifically, for the medical industry--in many ways an inherently "risky" business--hospitals and physicians have begun evaluating the impact of Al tools on their professional malpractice risk. This Essay seeks to address that question, zooming in on how AI may affect physicians' standard of care for medical malpractice claims.

A Qualitative Look At College Students Perceptions Of Social Interactions In College Physical Activity Classes, David C. Barney, Teresa Leavitt

Faculty Publications

Physical activity (PA) has been found to benefit a person in many ways. One of the benefits of being physically active is the social component. This deals with interacting with someone before, during or after the activity. The purpose of this study was to investigate the effects of social interactions effects on college-aged students during their PA class. Participants for this study included 408 college-aged students (272 males & 136 females) who were surveyed regarding their interactions during their PA class. The survey contained Likert scale questions and open-ended questions, requiring the students to respond with written answers. In short, …

Transformed By The Call, Glenn Russell

Faculty Publications

No abstract provided.

Psychological Body Armor: Factors That Contribute To Resilience Capacity, Harvey J. Burnett Jr.

Faculty Publications

No abstract provided.

Associations Of Maternal Resources With Care Behaviours Differ By Resource And Behaviour, Sulochana Basnet, Edward A. Frongillo Jr., Phuong Hong Nguyen, Spencer Moore, Mandana Arabi

Faculty Publications

Care is important for children's growth and development, but lack or inadequacy of resources for care can constrain appropriate caregiving. The objectives of this study were to examine whether maternal resources for care are associated with care behaviours specifically infant and young child feeding, hygiene, health-seeking, and family care behaviours. The study also examined if some resources for care are more important than others. This study used baseline Alive & Thrive household surveys from Bangladesh, Vietnam, and Ethiopia. Measures of resources for care were maternal education, knowledge, height, nourishment, mental well-being, decision-making autonomy, employment, support in chores, and perceived instrumental …

Adult Smokers’ Awareness And Interest In Trying Heated Tobacco Products: Perspectives From Mexico, Where Htps And E-Cigarettes Are Banned, Lizeth Cruz-Jiménez, Inti Barrientos-Gutiérrez, Liliana Coutiño-Escamilla, Katia Gallegos-Carrillo, Edna Arillo-Santillán, Jim Thrasher

Faculty Publications

Background: We evaluated smokers’ perceptions of heated tobacco products (HTPs) in Mexico, where industry publically lobbied to introduce HTPs into this country that banned both HTPs and e-cigarettes. Methods: Online surveys (November 2018 to July 2019) were analyzed from adults who only smoked cigarettes (n = 2091) or who smoked and used e-cigarettes (“dual users” n = 1128). Logistic models regressed HTP awareness, interest to trying HTPs, and having seen HTPs for sale (only among aware participants) on sociodemographics and tobacco-related variables. Results: Of the 17.1% who were aware of HTPs, 52.7% reported having seen HTPs for sale. Of all …

Developing Outreach Events That Impact Underrepresented Students: Are We Doing It Right?, Andrew J. Gall, Peter J. Vollbrecht, Tristan Tobias

Faculty Publications

Many outreach programs share the common goals of serving underrepresented groups in STEM and improving public attitudes toward science. To meet these goals, scientists must find ways to both reach the appropriate audience and communicate the importance of science in meaningful and accessible ways. This requires careful consideration of the outreach method being used. Two common outreach methods include in‐school visits (scientist in the classroom) and science fairs or open houses. Here, we compare the effectiveness of these two outreach methods in meeting the goals of reaching underrepresented students and/or students with less initial interest in science. We have found …

Speech Exemplar And Evaluation Database (Seed) For Clinical Training In Articulatory Phonetics And Speech Science, Marisha Speights Atkins, Dallin J. Bailey, Suzanne E. Boyce

Faculty Publications

One challenge faced by teachers of phonetics, speech science, and clinical speech disorders courses is providing meaningful instruction that closes the theory to practice gap. One barrier to providing this type of deep learning experience is the lack of publicly available examples of speech recordings that illustrate comparisons between typical and disordered speech production across a broad range of disorder populations. Data of this type exist, but are typically collected for specific research projects under narrowly written IRB protocols that do not allow for release of even de-identified speech recordings to other investigators or teachers. As a partial corrective to …

Functional Blockade Of E-Selectin In Tumor-Associated Vessels Enhances Anti-Tumor Effect Of Doxorubicin In Breast Cancer, Yoshihiro Morita, Macall Leslie, Hiroyasu Kameyama, Ganesh L. Lokesh, Norihisa Ichimura, Rachel Davis, Natalie Hills, Nafis Hasan, Roy Zhang, Yuji Kondo, David G. Gorenstein, David E. Volk, Inna Chervoneva, Hallgeir Rui, Takemi Tanaka

Faculty Publications

Chemotherapy is a mainstay of treatment for solid tumors. However, little is known about how therapy-induced immune cell infiltration may affect therapy response. We found substantial CD45 immune cell density adjacent to E-selectin expressing inflamed vessels in doxorubicin (DOX)-treated residual human breast tumors. While CD45 level was significantly elevated in DOX-treated wildtype mice, it remained unchanged in DOX-treated tumors from E-selectin null mice. Similarly, intravenous administration of anti-E-selectin aptamer (ESTA) resulted in a significant reduction in CD45 immune cell density in DOX-treated residual tumors, which coincided with a delay in tumor growth and lung metastasis in MMTV-pyMT mice. Additionally, both …

Controlling Their Own Destiny: Latin American Agency In The Context Of Us Hegemony, Dexter S. Boniface

Faculty Publications

No abstract provided.