Digital Commons Network^™

Transepithelial Anti-Neuroblastoma Response To Kale Among Four Vegetable Juices Using In Vitro Model Co-Culture System, John Piletz, Yuhan Mao, Debarshi Roy, Bilal Qizilbash, Eurielle Nkamssi, Enleyona Weir, Jessica Graham, Mary Emmanuel, Suwaira Iqbal, Kellie Brue, Bidisha Roy Sengupta

Faculty Publications

Juicing vegetables is thought to be an anticancer treatment. Support exists for a rank order of anticancer greens (kale > dandelion > lettuce > spinach) based on degrees of bioavailability of different phytochemicals, also offset by some noxious molecules (i.e., calcium-oxalate). We developed a new in vitro transepithelial anti-neuroblastoma model system. The juices were diluted as predicted once in the small intestine. They were applied to apical Caco-2Bbe1 cells atop dividing SH-SY5Y neuroblastoma cells, and changes in transepithelial electrical resistance (TEER) and cell growth were considered with juice spectroscopies. Studied first in monoculture, kale and dandelion were the most cytostatic juices on SH-SY5Ys, …

How Much Hvac Energy Could Be Saved From The Occupant-Centric Smart Home Thermostat: A Nationwide Simulation Study, Zhihong Pang, Yan Chen, Jian Zhang, Zheng O'Neill, Hwakong Cheng, Bing Dong

Faculty Publications

Thermostat management plays a significant role in household energy conservation. This study aims to conduct a systematic and comprehensive analysis to quantify the energy savings potential of the occupant-centric smart thermostat based on a large-scale nationwide simulation infrastructure. The single-family Residential Prototype Building Model was used to represent a typical single-family detached house in the U.S. A generalized random occupancy presence schedule was created based on an occupancy probability schedule and k-means clustering algorithm. A total of 16,000 simulations, which were composed of four building foundation types, four heating source types, 40 American cities, five building energy code versions, and …

The Establishment Clause: Its Original Public Meaning And What We Can Learn From The Plain Text, Carl H. Esbeck

Faculty Publications

Modern times in church-state relations began in 1947 with the Supreme Court’s decision in Everson v. Board of Education. The justices in both the majority and dissent said they were interpreting the Establishment Clause based on the intent of the founding generation. However, rather than looking to Congress’s lawmaking in the summer of 1789 that led to the First Amendment, the justices relied on the Virginia disestablishment from four years prior, as well as the efforts of just two statesmen, James Madison and Thomas Jefferson.

For the next half century, the High Court’s search was for events and prominent …

Plausible Harassment, Joseph Seiner

Faculty Publications

Despite the overwhelming public awareness of sexual harassment in the workplace, many federal courts still apply an unnecessarily stringent evidentiary burden to these claims. Following the Supreme Court’s lead in Bell Atlantic Corp. v. Twombly, 550 U.S. 544 (2007), and Ashcroft v. Iqbal, 556 U.S. 662 (2009), the lower courts have imposed a heightened plausibility pleading standard on harassment cases, preventing these claims from proceeding at the nascent stages of the case.

Workplace harassment is an undeniable fact of our society, and the courts should accept this fact when it is pled in a discrimination complaint, rather than prematurely eviscerating …

Neural Responses To Happy, Fearful And Angry Faces Of Varying Identities In 5-And 7-Month-Old Infants, Laurie Bayet, Katherine L. Perdue, Hannah F. Behrendt, John E. Richards, Alissa Westerlund, Julia K. Cataldo, Charles A. Nelson Iii

Faculty Publications

The processing of facial emotion is an important social skill that develops throughout infancy and early childhood. Here we investigate the neural underpinnings of the ability to process facial emotion across changes in facial identity in cross-sectional groups of 5- and 7-month-old infants. We simultaneously measured neural metabolic, behavioral, and autonomic responses to happy, fearful, and angry faces of different female models using functional near-infrared spectroscopy (fNIRS), eye-tracking, and heart rate measures. We observed significant neural activation to these facial emotions in a distributed set of frontal and temporal brain regions, and longer looking to the mouth region of angry …

Novel Adjective Processing In Preschool Children: Evidence From Event-Related Brain Potentials, Katelyn L. Gerwin, Laurence B. Leonard, Jennifer Schumaker, Patricia Deevy, Eileen Haebig, Christine Weber

Faculty Publications

Purpose: Recent findings in preschool children indicated novel adjective recall was enhanced when learned using repeated retrieval with contextual reinstatement (RRCR) compared to repeated study (RS). Recall was similar for learned pictures used during training and new (generalized) pictures with the same adjective features. The current study compared the effects of learning method and learned/ generalized pictures on the neural processes mediating the recognition of novel adjectives. Method: Twenty typically developing children aged 4;6– 5;11 (years;months) learned four novel adjectives, two using RRCR and two using RS. Five-minute and 1-week tests assessed adjective recall using learned and generalized pictures. Also, …

Interdependencies Between Acoustic And High-Speed Videoendoscopy Parameters, Patrick Schlegel, Andreas M. Kist, Melda Kunduk, Stephan Dürr, Michael Döllinger, Anne Schützenberger

Faculty Publications

In voice research, uncovering relations between the oscillating vocal folds, being the sound source of phonation, and the resulting perceived acoustic signal are of great interest. This is especially the case in the context of voice disorders, such as functional dysphonia (FD). We investigated 250 high-speed videoendoscopy (HSV) recordings with simultaneously recorded acoustic signals (124 healthy females, 60 FD females, 44 healthy males, 22 FD males). 35 glottal area waveform (GAW) parameters and 14 acoustic parameters were calculated for each recording. Linear and non-linear relations between GAW and acoustic parameters were investigated using Pearson correlation coefficients (PCC) and distance correlation …

Digital Anthropometry For Body Circumference Measurements: Toward The Development Of Universal Three-Dimensional Optical System Analysis Software, Sima Sobhiyeh, Samantha Kennedy, Alexander Dunkel, Marcelline E. Dechenaud, Jerome A. Weston, John Shepherd, Peter Wolenski, Steven B. Heymsfield

Faculty Publications

Background/Objective: Digital anthropometric (DA) assessments are increasingly being administered with three-dimensional (3D) optical devices in clinical settings that manage patients with obesity and related metabolic disorders. However, anatomic measurement sites are not standardized across manufacturers, precluding use of published reference values and pooling of data across research centers. Subjects/Methods: This study aimed to develop universal 3D analysis software by applying novel programming strategies capable of producing device-independent DA estimates that agree with conventional anthropometric (CA) measurements made at well-defined anatomic sites. A series of technical issues related to proprietary methods of 3D geometrical reconstruction and image analysis were addressed in …

Applying Spatial Video Geonarratives And Physiological Measurements To Explore Perceived Safety In Baton Rouge, Louisiana, Alina Ristea, Michael Leitner, Bernd Resch, Judith Stratmann

Faculty Publications

Spatial crime analysis, together with perceived (crime) safety analysis have tremendously benefitted from Geographic Information Science (GISc) and the application of geospatial technology. This research study discusses a novel methodological approach to document the use of emerg-ing geospatial technologies to explore perceived urban safety from the lenses of fear of crime or crime perception in the city of Baton Rouge, USA. The mixed techniques include a survey, spatial video geonarrative (SVG) in the field with study participants, and the extraction of moments of stress (MOS) from biosensing wristbands. This study enrolled 46 participants who completed geonarratives and MOS detection. A …

Increased Mood Disorder Symptoms, Perceived Stress, And Alcohol Use Among College Students During The Covid-19 Pandemic, Nora E. Charles, Stephanie J. Strong, Lauren C. Burns, Margaret R. Bullerjahn, Katherine M. Serafine

Faculty Publications

The COVID-19 pandemic caused significant disruption during the spring of 2020. Many college students were told to leave campus at spring break and to complete the semester remotely. This study evaluates effects of this disruption on student well-being. Measures of psychological symptoms, perceived stress, and alcohol use during the pandemic were completed by 148 students in spring 2020 and 352 students in fall 2020 at a university in the southeastern U.S. Results from both cohorts were compared to 240 students who completed the same measures in the fall 2019 semester. Participants in spring 2020 reported more mood disorder symptoms, perceived …

A Synthesis Of Deepwater Horizon Impacts On Coastal And Nearshore Living Marine Resources, Steven A. Murawski, Joshua P. Kilborn, Adriana C. Bejarano, David Chagaris, David Donaldson, Frank J. Hernandez, Timothy C. Macdonald, Craig Newton, Ernst Peebles, Kelly L. Robinson

Faculty Publications

The 2010 Deepwater Horizon (DWH) oil blowout in the Gulf of Mexico began on April 20, originating in the deep sea 66 km off the Louisiana coast. By early June, DWH oil had spread to coastal Louisiana, Mississippi, Alabama and western Florida. An estimated 2,113 km of shoreline were oiled, making DWH the largest marine oil spill in global history by length of affected shoreline. Additionally, a series of oil spill response measures were deployed, including diversions of Mississippi River discharge to forestall oil coming ashore, and the establishment of large-scale fishery closures, with both affecting coastal resources to varying …

Biophysical Characteristics Of Lipid-Induced Aβ Oligomers Correlate To Distinctive Phenotypes In Transgenic Mice, Jhinuk Saha, Dexter N. Dean, Shailendra Dhakal, Kelli A. Stockmal, Sarah E. Morgan, Kristy D. Dillon, Munir F. Adamo, Yona Levites, Vijayaraghavan Rangachari

Faculty Publications

Alzheimer's disease (AD) is a progressive neurodegenerative disorder that affects cognition and memory. Recent advances have helped identify many clinical sub-types in AD. Mounting evidence point toward structural polymorphism among fibrillar aggregates of amyloid-β (Aβ) to being responsible for the phenotypes and clinical manifestations. In the emerging paradigm of polymorphism and prion-like propagation of aggregates in AD, the role of low molecular weight soluble oligomers, which are long known to be the primary toxic agents, in effecting phenotypes remains inconspicuous. In this study, we present the characterization of three soluble oligomers of Aβ42, namely 14LPOs, 16LPOs, and GM1Os with discreet …

Multifunctional Films For Thermoplastic Composite Joints: Ultrasonic Welding And Damage Detection Under Tension Loading, Wencai Li, Harry Frederick, Genevieve Palardy

Faculty Publications

This paper investigates the use of multi-walled carbon nanotube/polypropylene (MWCNT/PP) films to enable ultrasonic welding and damage detection of glass fiber/polypropylene (GF/PP) composite joints in a single lap configuration. Three MWCNT concentrations above electrical percolation (15–25 wt%) were chosen to weld GF/PP adherends. The effect of MWCNT content on the welding process was evaluated by comparing weld quality through lap shear strength (LSS) tests and fractography analysis. Films containing 15 and 20 wt% MWCNT had no significant effect on the welding process, while 25 wt% reduced LSS by up to 39% compared to pure PP films due to their brittleness. …

Population Dynamics Of Arctic Alaska: A Graphical Library Of Changes In 102 Towns And Villages, 1990–2020, Lawrence C. Hamilton

Faculty Publications

No abstract provided.

The Importance Of Viewing Property As A System, Lynda L. Butler

Faculty Publications

Can--or should--the American property system adapt to curb the excesses inherent in the dominant form of capitalism? Those extolling the virtues of privatization of resources would likely answer in the negative. Such a response would ignore the core functions and infrastructure of the American institution of property. This Article discusses the structure of property that enables property law to evolve over time, reacting to changing conditions, recognizing informal customs and usages, and otherwise taking into account important feedbacks. It explains how property provides an ordering system of concepts and principles that define and govern relations between a society and its …

A Life Cycle Comparison Of Remote, Deployed Expeditionary Waste Management Scenarios, David J. Chester, Chandrani Mukherjee, Jeremy M. Slagley, Eric Mbonimpa, Thomas Hornstein

Faculty Publications

The current barrier to acquisition and utilization of viable waste-to-energy (WTE) technologies at remote or deployed expeditionary sites requires high capital and operation & maintenance costs. The impacts to environment and human health of differing expeditionary waste management strategies were compared using the Life Cycle Assessment software SimaPro 8.0. Emissions of individual waste management scenarios were compiled from peer-reviewed literature, converted to values compatible with SimaPro’s waste scenario inputs, and the calculated impacts compared using SimaPro’s pre-loaded methodologies. These calculated impacts and the economic impacts confirm that open-air burning of waste is not only dangerous to humans and the environment, …

From Surviving To Thriving: Effective Ministry And Evangelism In The Covid-19 Era And Beyond, S. Joseph Kidder, Willie Edward Hucks Ii

Faculty Publications

No abstract provided.

A Place Of One's Own: How Law Libraries Support Democracy By Protecting Citizens' Right To Read, Amy A. Emerson

Faculty Publications

By offering places for private reading and contemplation, law libraries foster wellinformed citizens capable of independent thought. This process, in turn, provides a foundation for understanding the law, questioning the law, and ultimately challenging the legal status quo, all necessary elements of a well-functioning democracy.

The Effects Of Source Cues And Issue Frames During Covid-19, Chandler Case, Christopher Eddy, Rahul Hemrajani, Christopher Howell, Daniel Lyons, Yu-Hsien Sung, Elizabeth C. Connors

Faculty Publications

The health and economic outcomes of the COVID-19 pandemic will in part be determined by how effectively experts can communicate information to the public and the degree to which people follow expert recommendation. Using a survey experiment conducted in May 2020 with almost 5,000 respondents, this paper examines the effect of source cues and message frames on perceptions of information credibility in the context of COVID-19. Each health recommendation was framed by expert or nonexpert sources, was fact- or experience-based, and suggested potential gain or loss to test if either the source cue or framing of issues affected responses to …

Pharmacokinetics And Pharmacodynamics Of Immediate- And Modified-Release Mycophenolic Acid Preparations In Healthy Beagle Dogs, Micheal Klotsman, Sebastien Coquery, Gayatri Sathyan, Vatsala Naageshwaran, Paddy Shivanand, Amanda J. Fairchild, Oliver A. Garden, Wayne H. Anderson

Faculty Publications

Background: Mycophenolic acid (MPA) is a broad-acting immunomodulating agent that may be therapeutically beneficial for the treatment of immune-mediated diseases in canine patients.

Objectives: To determine the suppressive effects of MPA on T-cell proliferation, and to assess the feasibility of a canine-specific q24 h modified-release MPA formulation (OKV-1001b).

Animals: Fifteen healthy purpose-bred male beagle dogs.

Methods: Two nearly identical open-label fifteen-day studies were conducted in which dogs were randomized to receive mycophenolate mofetil (MMF; 10 mg/kg q12h), or two doses of OKV-1001b (270 mg and 180 mg; q24h). Serial pharmacokinetic (PK) and pharmacodynamic (PD) samples were collected on Days 1, …

Integrating Survivors Of Stroke Into Exercise‐Based Cardiac Rehabilitation Improves Endurance And Functional Strength, Elizabeth Wherley Regan Dpt, Ph.D., Reed Handlery, Jill Campbell Stewart, Joseph Lee Pearson Ms,Drph, Sarah Wilcox Phd, Stacy L. Fritz Phd, Pt

Faculty Publications

Background

Cardiac rehabilitation (CR) is a structured exercise program prevalent in the United States for people with cardiovascular disease that has been shown to increase cardiovascular endurance and improve quality of life. Despite similar cardiovascular risk factors, stroke is not among the covered diagnoses for CR. The purpose of this study was to examine the participant impact of integrating survivors of stroke into the exercise portion of an existing hospital‐based CR program through measures of physical function and other health impacts and through qualitative evaluation of participant perception.

Methods and Results

Subacute and chronic survivors of stroke were integrated into …

Structural Insights Into The Disruption Of Tnf-Tnfr1 Signalling By Small Molecules Stabilising A Distorted Tnf, David Mcmillan, Carlos Martinez-Fleites, John Porter, David Fox, Rachel E. Davis, Prashant Mori, Tom Ceska, Bruce Carrington, Alastair Lawson, Tim Bourne, James O'Connell

Faculty Publications

Tumour necrosis factor (TNF) is a trimeric protein which signals through two membrane receptors, TNFR1 and TNFR2. Previously, we identified small molecules that inhibit human TNF by stabilising a distorted trimer and reduce the number of receptors bound to TNF from three to two. Here we present a biochemical and structural characterisation of the small molecule-stabilised TNF-TNFR1 complex, providing insights into how a distorted TNF trimer can alter signalling function. We demonstrate that the inhibitors reduce the binding affinity of TNF to the third TNFR1 molecule. In support of this, we show by X-ray crystallography that the inhibitor-bound, distorted, TNF …

Psychiatric Symptoms, Risk, And Protective Factors Among University Students In Quarantine During The Covid-19 Pandemic In China, Shufang Sun, Simon B. Goldberg, Danhua Lin, Shan Qiao Ph.D., Don Operario

Faculty Publications

Background: The COVID-19 pandemic has made unprecedented impact on the psychological health of university students, a population vulnerable to distress and mental health disorders. This study investigated psychiatric symptoms (anxiety, depression, and traumatic stress) during state-enforced quarantine among university students in China (N = 1912) through a cross-sectional survey during March and April 2020. Results: Psychiatric symptoms were alarmingly prevalent: 67.05% reported traumatic stress, 46.55% had depressive symptoms, and 34.73% reported anxiety symptoms. Further, 19.56% endorsed suicidal ideation. We explored risk and protective factors of psychological health, including demographic variables, two known protective factors for mental health (mindfulness, perceived social …

A Nationwide Population-Based Study On The Incidence Of Parapharyngeal And Retropharyngeal Abscess-A 10-Year Study, Tzong-Hann Yang, Sudha Xirasagar Mbbs., Ph.D., Yen-Fu Cheng, Chuan-Song Wu, Yi-Wei Kao, Herng-Ching Lin

Faculty Publications

This study aimed to investigate the annual incidence of parapharyngeal and retropharyngeal abscess (PRPA) based on 10-year population-based data. Patients with PRPA were identified from the Taiwan Health Insurance Research Database, a database of all medical claims of a randomly selected, population-representative sample of over two million enrollees of the National Health Insurance system that covers over 99% of Taiwan’s citizens. During 2007–2016, 5779 patients received a diagnosis of PRPA. We calculated the population-wide incidence rates of PRPA by sex and age group (20–44, 45–64, and >64) as well as in-hospital mortality. The annual incidence rate of PRPA was 2.64 …

Click Conjugation Of Boron Dipyrromethene (Bodipy) Fluorophores To Egfr-Targeting Linear And Cyclic Peptides, Tyrslai M. Williams, Nichole E.M. Kaufman, Zehua Zhou, Sitanshu S. Singh, Seetharama D. Jois, Maria Da Graça H. Vicente

Faculty Publications

Through a simple 1,3-cycloaddition reaction, three BODIPY-peptide conjugates that target the extracellular domain of the epidermal growth factor receptor (EGFR) were prepared and their ability for binding to EGFR was investigated. The peptide ligands K(N3)LARLLT and its cyclic analog cyclo(K(N3)larllt, previously shown to have high affinity for binding to the extracellular domain of EGFR, were conjugated to alkynyl-functionalized BODIPY dyes 1 and 2 via a copper-catalyzed click reaction. This reaction produced conjugates 3, 4, and 5 in high yields (70-82%). In vitro studies using human carcinoma HEp2 cells that overexpress EGFR demonstrated high cellular uptake, particularly for the cyclic peptide …

Anemia Management In Rural Haitian Children: A Mixed Methods Study, Marc-Aurel Martial, Kathy A. Sward, Janice M. Morse, Andrew R. Wilson, Cempaka S. Martial, Debra S. Penney, Elie Nicolas

Faculty Publications

Introduction: We examined factors influencing anemia outcomes in rural children following implementation of a prevention program. Method: Mixed methods study of children, parents, and clinicians utilized statistical modeling and content/ ethnographic analysis. Retrospective chart abstraction evaluated treatments administered and measured hemoglobin in children aged 6 to 59 months (n = 161). Prospective interviews/questionnaires examined parent (n = 51) and clinician (n = 19) perceptions. Results: Anemia prevalence decreased by 21.2%. Predictors of increased hemoglobin were clinic visit number and age at first visit. Once anemia improved, children were likely to remain improved (P = .65). Despite favorable program perceptions, stakeholders …

Supporting The Inclusion Of Socially Vulnerable Early Adolescents: Theory And Illustrations Of The Base Model, Thomas W. Farmer, Brittany I. Sterrett, Kate E. Norwalk, Chen-Chih Chen, Molly Dawes Ph.D., Jill V. Hamm, David L. Lee, Adaline G. Farmer

Faculty Publications

We focus on the inclusion of socially vulnerable early adolescents including students with special education needs (SEN). Building from multiple intervention and randomized control trials of a professional development model aimed at supporting teachers' management of the classroom social context, we provide an overview of the Behavioral, Academic, and Social Engagement (BASE) Model as a framework to foster social inclusion. We briefly review the conceptual foundations of this model and we present the delivery (i.e., directed consultation, the scouting report process) and content (i.e., Academic Engagement Enhancement, Competence Enhancement Behavior Management, Social Dynamics Management) components of BASE. We then briefly …

Neighborhood Characteristics And The Mental Health Of Caregivers Cohabiting With Care Recipients Diagnosed With Alzheimer’S Disease, Dana M. Alhasan, Jana A. Hirsch, Chandra L. Jackson, Margaret Chandlee Miller, Bo Cai Ph.D., Matthew C. Lohman Ph.D.

Faculty Publications

While studies have documented the influence of caregiver and care recipient factors on caregiver health, it is important to address the potential impact of neighborhood contexts. This study estimated the cross-sectional associations between neighborhood characteristics and mental health among caregivers cohabiting with Alzheimer’s disease care recipients that were experiencing severe or non-severe neuropsychiatric symptoms (NPSs) (e.g., aggression/anxiety). We obtained data collected in 2010 on caregivers and care recipients (n

While studies have documented the influence of caregiver and care recipient factors on caregiver health, it is important to address the potential impact of neighborhood contexts. This study estimated the cross-sectional …

Associations Of Maternal Dietary Inflammatory Potential And Quality With Offspring Birth Outcomes: An Individual Participant Data Pooled Analysis Of 7 European Cohorts In The Alphabet Consortium, Ling-Wei Chen, Adrien M. Aubert, Nitin Shivappa, Jonathan Y. Bernard, Sara M. Mensink-Bout, Aisling A. Geraghty, John Mehegan, Matthew Suderman, Kinga Polanska, Wojciech Hanke, Elzbieta Trafalska, Caroline L. Relton, Sarah R. Crozier, Nicholas C. Harvey, Cyrus Cooper, Liesbeth Duijts, Barbara Heude, James R. Hébert Scd, Fionnuala M. Mcauliffe, Cecily C. Kelleher, Catherine M. Phillips

Faculty Publications

Background

Adverse birth outcomes are major causes of morbidity and mortality during childhood and associate with a higher risk of noncommunicable diseases in adult life. Maternal periconception and antenatal nutrition, mostly focusing on single nutrients or foods, has been shown to influence infant birth outcomes. However, evidence on whole diet that considers complex nutrient and food interaction is rare and conflicting. We aim to elucidate the influence of whole-diet maternal dietary inflammatory potential and quality during periconceptional and antenatal periods on birth outcomes.

Methods and findings

We harmonized and pooled individual participant data (IPD) from up to 24,861 mother–child pairs …

Topsentinol L Trisulfate, A Marine Natural Product That Targets Basal-Like And Claudin-Low Breast Cancers, Nader N. El-Chaar, Thomas E. Smith, Gajendra Shrestha, Stephen R. Piccolo, Mary Kay Harper, Ryan M. Van Wagoner, Zhenyu Lu, Ashlee R. Venancio, Chris M. Ireland, Andrea H. Bild, Philip J. Moos

Faculty Publications

Patients diagnosed with basal-like breast cancer suffer from poor prognosis and limited treatment options. There is an urgent need to identify new targets that can benefit patients with basal-like and claudin-low (BL-CL) breast cancers. We screened fractions from our Marine Invertebrate Compound Library (MICL) to identify compounds that specifically target BL-CL breast cancers. We identified a previously unreported trisulfated sterol, i.e., topsentinol L trisulfate (TLT), which exhibited increased efficacy against BL-CL breast cancers relative to luminal/HER2+ breast cancer. Biochemical investigation of the effects of TLT on BL-CL cell lines revealed its ability to inhibit activation of AMP-activated protein kinase (AMPK) …