Digital Commons Network^™

A Pilot Study Of A Comprehensive School Physical Activity Program In Elementary Schools: Be A Champion!, Justin B. Moore, Robert Glenn Weaver Med,Phd, Beverly J. Levie, Camelia R. Sngletary, Russell L. Carson, Michael W. Beets Med, Mph, Phd, Darla M. Castelli, Aaron Beighle, Russell R. Pate Ph.D.

Faculty Publications

Objective: In the present study, we sought to determine if a comprehensive school physical activity program (CSPAP) delivered using the Be a Champion! (BAC) framework was effective in increasing moderate-to-vigorous physical activity (MVPA) and decreasing sedentary time in elementary school youth. Methods : We implemented a CSPAP in 3 elementary schools to determine its effectiveness to youth behaviors compared to 2 control schools. Youth physical activity was assessed via accelerometry in spring 2015 and spring 2016 during school hours on school days. Implementation of the BAC components and youth behavior was assessed through direct observation from fall 2015 through winter …

Discovery Of Clioquinol And Analogues As Novel Inhibitors Of Severe Acute Respiratory Syndrome Coronavirus 2 Infection, Ace2 And Ace2 - Spike Protein Interaction In Vitro, Omonike A. Olaleye, Manvir Kaur, Collins Onyenaka, Tolulope Adebusuyi

Faculty Publications

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), the etiological agent for coronavirus disease 2019 (COVID-19), has resulted in an ongoing pandemic. Presently, there are no clinically approved drugs for COVID-19. Hence, there is an urgent need to accelerate the development of effective antivirals. Herein, we discovered Clioquinol (5-chloro-7-iodo-8-quinolinol (CLQ)), a Food and Drug Administration (FDA) approved drug, and two of its analogues (7-bromo-5-chloro-8-hydroxyquinoline (CLBQ14); and 5, 7-Dichloro-8-hydroxyquinoline (CLCQ)) as potent inhibitors of SARS-CoV-2 infection-induced cytopathic effect in vitro. In addition, all three compounds showed potent anti-exopeptidase activity against recombinant human angiotensin-converting enzyme 2 (rhACE2) and inhibited the binding of rhACE2 …

Assessing Determinants Of Continuance Intention Towards Personal Cloud Services: Extending Utaut2 With Technology Readiness, Shih Chih Chen, Shing Han Li, Shih Chi Liu, David C. Yen, Athapol Ruangkanjanases

Faculty Publications

In addition to the rapid development of global information and communications technology (ICT) and the Internet, recent rapid growth in cloud computing technology represents another important trend. Individual continuance intention towards information technology is a critical area in which information systems research can be performed. This study aims to develop an integrated model designed to explain and predict an individual’s continuance intention towards personal cloud services based on the concepts of technology readiness (TR) and the unified theory of acceptance and use of technology 2 (UTAUT2), moderated by gender, age, and experience of personal cloud services. The key results of …

Immune Checkpoint-Related Serum Proteins And Genetic Variants Predict Outcomes Of Localized Prostate Cancer, A Cohort Study, Qinchuan Wang, Yuanqing Ye, Hao Yu, Shu Hong Lin, Huakang Tu, Dong Liang, David W. Chang, Maosheng Huang, Xifeng Wu

Faculty Publications

Background: The clinical predictors and biological mechanisms for localized prostate cancer (PCa) outcomes remain mostly unknown. We aim to evaluate the role of serum immune-checkpoint-related (ICK) proteins and genetic variations in predicting outcomes of localized PCa. Methods: We profiled the serum levels of 14 ICK-related proteins (BTLA, GITR, HVEM, IDO, LAG-3, PD-1, PD-L1, PD-L2, Tim-3, CD28, CD80, 4-1BB, CD27, and CTLA-4) in 190 patients with localized PCa. The genotypes of 97 single nucleotide polymorphisms (SNPs) from 19 ICK-related genes were analyzed in an extended population (N = 1762). Meta-data from ArrayExpress and TCGA was employed to validate and to probe …

The Interrelationship Between Water Access, Exclusive Breastfeeding And Diarrhea In Children: A Cross-Sectional Assessment Across 19 African Countries, Paschal A. Apanga, Ann M. Weber, Lyndsey A. Darrow, Mark S. Riddle, Wei-Chen Tung, Yan Liu, Joshua V. Garn

Faculty Publications

Background Access to an improved water supply and practicing exclusive breastfeeding are essential for improving maternal and child health outcomes. However, few studies have been equipped to assess the interdependencies between access to improved water, practicing exclusive breastfeeding, and child health. The primary aim of our study was to assess whether access to an improved water supply and water-fetching were associated with mothers’ practice of exclusive breastfeeding.

Methods We analyzed data on 247090 mothers with children 5 months old or less using Multiple Indicator Cluster Surveys from 19 African countries. Multivariable logistic regression was used to estimate the relationship between …

Ugandan Adolescents' Attitudes Toward, And Shared Activities With, Same And Other-Gender Peers And Friends, Flora Farago, J. Xu, Natalie D. Eggum-Wilkens, Linlin Zhang, Danming An, Eunjung Kim, Emily Adams

Faculty Publications

Ugandan adolescents (n = 202, 54% girls; M_age = 14.26) answered closed- and open-ended questions about the gender composition of friends and attitudes about, and activities with, same- and other-gender peers and friends. Adolescents’ friendships were somewhat gender segregated, although other-gender friendships were present. Positive attitudes about same- and other-gender peers and friends were prevalent. Girls and boys displayed similar attitudes about same- and other-gender peers, with the exception of boys reporting more positive attitudes toward boys. Adolescents enjoyed the following aspects of same- and other-gender friendships: talking about problems, receiving help, sharing items and activities, receiving advice …

Food Insecurity And Food Access During Covid-19 In The San Francisco Bay Area, Giselle Pignotti, Marcelle Dougan, Iris Tablas-Mejia, Adriana Telias, Ashnee Gounden

Faculty Publications

The coronavirus (COVID-19) pandemic impacted socio-economic stability and food systems in the U.S. and worldwide. To better understand food access challenges and needs of those significantly impacted by the pandemic, an online survey was distributed in the San Francisco Bay Area from August to November of 2020. A total of 726 participants completed the survey who were recruited through paid Facebook ads and community partners outreach. This report features key results from the survey regarding changes in food security rates, food access challenges, and coping strategies used during the pandemic. Some of the key findings include: 1) There was a …

Marine Phytoplankton Responses To Oil And Dispersant Exposures: Knowledge Gained Since The Deepwater Horizon Oil Spill, Antonietta Quigg, Michael Parsons, Sibel Bargu, Koray Ozhan, Kendra L. Daly, Sumit Chakraborty, Manoj Kamalanathan, Deana Erdner, Sarah Cosgrove, Edward J. Buskey

Faculty Publications

The Deepwater Horizon oil spill of 2010 brought the ecology and health of the Gulf of Mexico to the forefront of the public's and scientific community's attention. Not only did we need a better understanding of how this oil spill impacted the Gulf of Mexico ecosystem, but we also needed to apply this knowledge to help assess impacts from perturbations in the region and guide future response actions. Phytoplankton represent the base of the food web in oceanic systems. As such, alterations of the phytoplankton community propagate to upper trophic levels. This review brings together new insights into the influence …

Preparedness, Planning, And Advances In Operational Response, David G. Westerholm, Cameron H. Ainsworth, Christopher H. Barker, Peter G. Brewer, John W. Farrington, Dubravko Justić, Vassiliki H. Kourafalou, Steven A. Murawski, John G. Shepherd, Helena M. Solo-Gabriele

Faculty Publications

During the last 50 years, the numbers and sizes of oil spills have been significantly reduced through prevention. But spills still occur, and it is critical to prepare for these events through planning and exercises. Operational decisions are designed to expedite cleanup and minimize overall impacts, yet they often involve complex tradeoffs between a multitude of competing interests. It is imperative to apply the best technology and science when events occur. However, while planning and response tactics have evolved over time, determining what may be most at risk is often confounded by sparse background data, modeling limitations, scalability, or research …

Physical Transport Processes That Affect The Distribution Of Oil In The Gulf Of Mexico Observations And Modeling, Michel Boufadel, Annalisa Bracco, Eric P. Chassignet, Shuyi S. Chen, Eric D’Asaro, William K. Dewar, Oscar Garcia-Pineda, Dubravko Justić, Joseph Katz, Vassiliki H. Kourafalou, Ian R. Macdonald, Tamay M. Özgökmen, Claire B. Paris-Limouzy, Scott S. Socolofsky, David Halpern, John G. Shepherd

Faculty Publications

Physical transport processes such as the circulation and mixing of waters largely determine the spatial distribution of materials in the ocean. They also establish the physical environment within which biogeochemical and other processes transform materials, including naturally occurring nutrients and human-made contaminants that may sustain or harm the region’s living resources. Thus, understanding and modeling the transport and distribution of materials provides a crucial substrate for determining the effects of biological, geological, and chemical processes. The wide range of scales in which these physical processes operate includes microscale droplets and bubbles; small-scale turbulence in buoyant plumes and the near-surface “mixed” …

Three-Dimensional Analysis Of The Effect Of Human Movement On Indoor Airflow Patterns, Arup Bhattacharya, Jovan Pantelic, Ali Ghahramani, Ehsan S. Mousavi

Faculty Publications

Human activity is known to leave significant effects on indoor airflow patterns. These patterns are carefully designed for many facilities such as cleanrooms, pharmaceutical settings, and healthcare environments, where human-induced wakes contribute to the transport of contaminants. Therefore, the knowledge about these wakes as it relates to indoor air quality is critical. As a result, a series of experiments were conducted in a controlled chamber to study the three-dimensional effects of true human walking on airflow. Experiments were designed to capture the effect of human walking under three different flow conditions, and for two different walking schemes. The results show …

Evidence-Based Use Of Cognitive Testing For Academic Interventions: A Critical Appraisal Of Meta-Analytic Methodologies, Scott L. Decker, Jessica C. Luedke

Faculty Publications

Research suggests Specific Learning Disabilities (SLD) are directly linked to specific neurocognitive deficits that result in unexpected learning delays in academic domains for children in schools. However, meta-analytic studies have failed to find supporting evidence for using neurocognitive tests and, consequently, have discouraged their inclusion in SLD identification policies. The current study critically reviews meta-analytic findings and the methodological validity of over 200 research studies used in previous meta-analytic studies to estimate the causal effect of neurocognitive tests on intervention outcomes. Results suggest that only a very small percentage (6–12%) of studies used in previous meta-analytic studies were methodologically valid …

Cost-Effectiveness Analysis Of Radiotherapy Techniques For Whole Breast Irradiation, Yibo Xie, Beibei Guo, Rui Zhang

Faculty Publications

Background The current standard of care (SOC) for whole breast radiotherapy (WBRT) in the US is conventional tangential photon fields. Advanced WBRT techniques may provide similar tumor control and better normal tissue sparing, but it is controversial whether the medical benefits of an advanced technology are significant enough to justify its higher cost. Objective To analyze the cost-effectiveness of six advanced WBRT techniques compared with SOC. Methods We developed a Markov model to simulate health states for one cohort of women (65-year-old) with early-stage breast cancer over 15 years after WBRT. The cost effectiveness analyses of field-in-field (FIF), hybrid intensity …

A Facility For The Research, Development, And Translation Of Advanced Technologies For Ion-Beam Therapies, M. Lis, W. Newhauser, M. Donetti, M. Durante, U. Weber, B. Zipfel, C. Hartmann-Sauter, M. Wolf, C. Graeff

Faculty Publications

This article describes the updated GSI radiotherapy research facility (Cave M) located at the GSI Helmholtz Center for Heavy Ion Research in Darmstadt, Germany. This facility was upgraded by modernizing the beamline that supported a pilot project in carbon ion cancer therapy in Europe from 1997 to 2008. Descriptions are provided of the modernized beamline, related hardware components and treatment delivery system. The performance specifications and general characteristics for each major component are described, along with example pre-clinical test results of selected components. These upgrades to Cave M allow for investigating novel therapy methods. The radiotherapy research facility is located …

Health Differences Between Religious And Secular Subgroups In The United States: Evidence From The General Social Survey, Mark H. Walker, Leah Drakeford, Samuel Stroope, Joseph O. Baker, Alexander L. Smith

Faculty Publications

Religious nonaffiliates who have high certainty in the existence of God or a higher power (theistic nones) have grown rapidly in size in the U.S. in the last 30 years, and are now the fourth largest American religious or secular category. This subgroup has been overlooked in prior research on religion, secularism, and health. We build on recent work on religion and health by distinguishing between atheists, agnostics, and nonaffliliated theists when examining the link between religious or secular identification and self-rated health. Specifically, we advance research on the heterogeneity of secular individuals and health by splitting nonaffiliated theists into …

Revamping Ecosystem Services Through Agroecology—The Case Of Cereals, Gomathy Sethuraman, Nurul Amalina Mohd Zain, Sumiani Yusoff, Yin Mei Ng, Niranjan Baisakh, Acga Cheng

Faculty Publications

Globally, farming systems are mostly dominated by monoculture, which has the advantage of profitability at the expense of ecological systems. Recent years have witnessed an increasing mo-mentum in global efforts to deploy sustainable agriculture practices that mimic ecological processes, with agroecology at the forefront. In addition to the ecological aspect, agroecology also encompasses economic and social aspects targeting the whole food system. Transformative agroecology has been recognized as a stepping stone to achieving several Sustainable Development Goals (SDGs), due to its great potential to build climate change-resilient farming systems while enhancing ecosystem services and reducing biodiversity loss. Nonetheless, the available …

The Association Between Quitline Characteristics And Smoking Cessation By Educational Attainment, Income, Race/Ethnicity, And Sex, David C. Colston, Bethany J. Simard, Yanmei Xie, Marshall Chandler Mcleod, Micheal R. Elliott, Jim F. Thrasher Ph.D., Ma, Ms, Nancy L. Fleischer

Faculty Publications

Little research examines how tobacco quitlines affect disparities in smoking cessation in the United States. Our study utilized data from the Tobacco Use Supplement to the Current Population Survey (2010, 2011, 2012, 2015, 2018) (TUS-CPS) and state-level quitline data from the North American Quitline Consortium and National Quitline Data Warehouse. We ran multilevel logistic regression models assessing a state-run quitline’s budget, reach, number of counseling sessions offered per caller, and hours of operation on 90-day smoking cessation. Multiplicative interactions between all exposures and sex, race/ethnicity, income, and education were tested to understand potential effect modification. We found no evidence that …

Learners’ Motivational Response To The Science, Pe, & Me! Curriculum: A Situational Interest Perspective, Senlin Chen, Haichun Sun, Xihe Zhu, Ang Chen, Catherine D. Ennis (Posthumous)

Faculty Publications

Background: The Science, PE, & Me! (SPEM) curriculum is a concept-based physical education curriculum that offers students coherent educational experiences for constructing health-related fitness knowledge through movement experiences. The purpose of this study was to evaluate students’ motivational response to the SPEM curriculum from the situational interest perspective. Methods: The study used a cluster randomized controlled design in which 30 elementary schools in one of the largest metropolitan areas in the eastern United States were randomly assigned to an experimental or comparison condition. Although all students in the 3rd, 4th, and 5th grades in the targeted schools were eligible to …

Juvenile Punishment, High School Graduation, And Adult Crime: Evidence From Idiosyncratic Judge Harshness, Ozkan Eren, Naci Mocan

Faculty Publications

This paper contributes to the debate on the impact of juvenile crime punishment on high school completion and adult recidivism using administrative data from a southern U.S. state. We exploit random assignment of cases to judges and use idiosyncratic judge stringency in imprisonment to estimate the causal effect of incarceration. We find that juvenile incarceration increases the propensity of being convicted for a drug offense in adulthood while it lowers the propensity to be convicted of a property crime. Juvenile incarceration has also a detrimental effect on high school completion for earlier cohorts, but it has no impact on later …

Cost Effectiveness Of Community Led Total Sanitation In Ethiopia And Ghana, Jonny Crocker, David Fuente, Jamie Bartram

Faculty Publications

We conducted cost effectiveness analyses of four different CLTS interventions implemented in Ethiopia and Ghana. In each country, a pilot approach in which additional local actors were trained in CLTS facilitation was compared to the conventional approach. Data were collected using bottom-up costing, household surveys, and observations. We assessed variability of cost effectiveness from a societal perspective for latrine ownership and latrine use outcomes in different contexts. Cost effectiveness ranged from $34–$1897 per household ($5.85–$563 per person) gaining access to a private latrine or stopping open defecation, depending on the intervention, context, and outcome considered. For three out of four …

The Lost Promise Of Disability Rights, Claire Raj

Faculty Publications

Children with disabilities are among the most vulnerable students in public schools. They are the most likely to be bullied, harassed, restrained, or segregated. For these and other reasons, they also have the poorest academic outcomes. Overcoming these challenges requires full use of the laws enacted to protect these students’ affirmative right to equal access and an environment free from discrimination. Yet, courts routinely deny their access to two such laws—the Americans with Disabilities Act (ADA) and section 504 of the Rehabilitation Act of 1973 (section 504).

Courts too often overlook the affirmative obligations contained in these two disability rights …

No Evidence That Salt Water Ingestion Kills Adult Mosquitoes (Diptera: Culicidae), Donald A. Yee, Catherine Dean, Cameron Webb, Jennifer A. Henke, Gabriela Perezchica-Harvey, Gregory S. White, Ary Faraji, Joshua D. Macaluso, Rebecca Christofferson

Faculty Publications

Various products and insecticides are available that purport to reduce wild populations of adult mosquitoes. Recently, several manufacturers and general public comments on the internet have promoted devices that claim that ingestion of salt will significantly reduce populations of wild mosquitoes to near zero; there are no known scientific efficacy data that support these claims. We tested the survival of nine mosquito species of pest and public health importance across four adult diets: Water Only, Sugar Water Only (8.00%), Salt Water Only (1.03%), and Sugar + Salt Water. Species included the following: Aedes aegypti (L.), Aedes albopictus (Skuse), Aedes dorsalis …

Prospects For Gulf Of Mexico Environmental Recovery And Restoration, Denis A. Wiesenburg, Bob Shipp, F. Joel Fodrie, Sean Powers, Julien Lartigue, Kelly M. Darnell, Melissa M. Baustian, Cam Ngo, John F. Valentine, Kateryna Wowk

Faculty Publications

Previous oil spills provide clear evidence that ecosystem restoration efforts are challenging, and recovery can take decades. Similar to the Ixtoc 1 well blowout in 1979, the Deepwater Horizon (DWH) oil spill was enormous both in volume of oil spilled and duration, resulting in environmental impacts from the deep ocean to the Gulf of Mexico coastline. Data collected during the National Resource Damage Assessment showed significant damage to coastal areas (especially marshes), marine organisms, and deep-sea habitat. Previous spills have shown that disparate regions recover at different rates, with especially long-term effects in salt marshes and deepsea habitat. Environmental recovery …

Response Inhibition Deficits In Women With The Fmr1 Premutation Are Associated With Age And Fall Risk, Carly Moser, Lyndsay Schmitt, Joseph Schmidt, Amanda Fairchild, Jessica Klusek

Faculty Publications

One in 113-178 females worldwide carry a premutation allele on the FMR1 gene. The FMR1 premutation is linked to neurocognitive and neuromotor impairments, although the phenotype is not fully understood, particularly with respect to age effects. This study sought to define oculomotor response inhibition skills in women with the FMR1 premutation and their association with age and fall risk. We employed an antisaccade eye-tracking paradigm to index oculomotor inhibition skills in 35 women with the FMR1 premutation and 28 control women. The FMR1 premutation group exhibited longer antisaccade latency and reduced accuracy relative to controls, indicating deficient response inhibition skills. …

Elaborating The Science Of Food Choice For Rapidly Changing Food Systems In Low-And Middle-Income Countries, Christine E. Blake Ph.D., Rd, Edward A. Frongillo Jr. Ph.D., Andrea M. Warren, Shilpa V. Constantinides, Krystal K. Rampalli, Shiva Bhandari

Faculty Publications

The world’s food systems and environments have been changing dramatically, concomitant with changes in overand undernutrition. We elaborate the science of food choice to better understand, analyze, and respond to relationships between changing food environments and food choice. The science of food choice is concerned with generating knowledge about causal drivers of food choice decision making processes and behavior within immediate food and social environments. Three fundamental and interconnected questions undergird this science; 1) what do people eat from the options available and accessible?; 2) how do people interact with food environments?; and 3) why do people decide to acquire, …

The Costs Of Dissent: Protest And Civil Liabilities, Timothy Zick

Faculty Publications

This Article examines the civil costs and liabilities that apply to individuals who organize, participate in, and support protest activities. Costs ranging from permit fees to punitive damages significantly affect First Amendment speech, assembly, and petition rights. A variety of common law and statutory civil claims also apply to protest activities. Plaintiffs have recently filed a number of new civil actions negatively affecting protest, including "negligent protest," "aiding and abetting defamation," "riot boosting," "conspiracy to protest," and "tortious petitioning." The labels are suggestive of the threats these suits pose to First Amendment rights. All of these costs and liabilities add …

The Opioid Doctors: Is Losing Your License A Sufficient Penalty For Dealing Drugs?, Adam M. Gershowitz

Faculty Publications

Imagine that a medical board revokes a doctor's license both because he has been peddling thousands of pills of opioids and also because he was caught with a few grams of cocaine. The doctor is a family physician, not a pain management specialist. Yet, during a one-year period he wrote more than 4,000 prescriptions for opioids--roughly eighteen scripts per day. Patients came from multiple states and from hundreds of miles away to get oxycodone prescriptions. And the doctor prescribed large quantities of opioids--up to 240 pills per month--to patients with no record of previously needing narcotic painkillers. Both federal and …

Never Waste A Crisis: Digital Inclusion For Sustainable Development In The Context Of The Covid Pandemic, Amanda Reed, Kim M. Thompson

Faculty Publications

In responding to United Nations’ Sustainable Development Goals in 2030, the International Federation of Library Associations and Institutions recently launched the mutual commitment of Library Pledge for Digital Inclusion and its Call to Action along with other international organizations. Domestic and foreign library leaders and well-known experts and scholars discuss the theme of Library and Digital Inclusion. Rao Quan points out that with the development of modern technology, the digital divide has become a growing problem. The National Library of China has put forward an idea of building a “National Smart Library System”, to lead public libraries to realize smart …

Consolo Aos Pequeninos, S. Joseph Kidder, Natalie Dorland

Faculty Publications

No abstract provided.

Forging The Chaplain's Pastoral Identity, Anna M. Galeniece

Faculty Publications

No abstract provided.