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Glucuronides Hydrolysis By Intestinal Microbial Β-Glucuronidases (Gus) Is Affected By Sampling, Enzyme Preparation, Buffer Ph, And Species, Christabel Ebuzoeme, Imoh Etim, Autumn Ikimi, Jamie Song, Ting Du, Ming Hu, Dong Liang, Song Gao Jul 2021

Glucuronides Hydrolysis By Intestinal Microbial Β-Glucuronidases (Gus) Is Affected By Sampling, Enzyme Preparation, Buffer Ph, And Species, Christabel Ebuzoeme, Imoh Etim, Autumn Ikimi, Jamie Song, Ting Du, Ming Hu, Dong Liang, Song Gao

Faculty Publications

Glucuronides hydrolysis by intestinal microbial β-Glucuronidases (GUS) is an important procedure for many endogenous and exogenous compounds. The purpose of this study is to deter-mine the impact of experimental conditions on glucuronide hydrolysis by intestinal microbial GUS. Standard probe 4-Nitrophenyl β-D-glucopyranoside (pNPG) and a natural glucuronide wogonoside were used as the model compounds. Feces collection time, buffer conditions, interindividual, and species variations were evaluated by incubating the substrates with enzymes. The relative reaction activity of pNPG, reaction rates, and reaction kinetics for wogonoside were calculated. Fresh feces showed the highest hydrolysis activities. Sonication increased total protein yield during enzyme preparation. …


Ugandan Adolescents’ Descriptive Gender Stereotypes About Domestic And Recreational Activities, And Attitudes About Women, Flora Farago, Natalie Eggum-Wilkens, Linlin Zhang Jul 2021

Ugandan Adolescents’ Descriptive Gender Stereotypes About Domestic And Recreational Activities, And Attitudes About Women, Flora Farago, Natalie Eggum-Wilkens, Linlin Zhang

Faculty Publications

In Eastern Uganda, 201 adolescents aged 11- to 17-years old (48% girls; Mage = 14.62) answered close- and open-ended questions about gender stereotypes of domestic and recreational activities and gender-role attitudes about women’s behavior, rights, and roles. Adolescents answered questions such as “who is more likely to . . .?” assessing descriptive stereotypes (i.e., stereotype knowledge) and questions such as “is it ok for women to . . .?” assessing prescriptive stereotypes (i.e., stereotype endorsement) about gender roles. Data were analyzed via descriptive statistics, correlations, and thematic coding. Findings indicate that Ugandan adolescents were fairly egalitarian in some domains …


Physical Activity Among Adults Residing In 11 Countries During The Covid-19 Pandemic Lockdown, Kele Ding, Jingzhen Yang, Ming-Kai Chin, Lindsay Sullivan, J. Larry Durstine, Verónica Violant-Holz, Giyasettin Demirhan, Nara R.C. Oliveira, Biljana Popeska, Garry Kuan, Waheeda Khan, Jianhui Dai, Xia Xu, Zornitza Mladenova, Govindasamy Balasekaran, Gary A. Smith, Global Community Health-Covid-19 Collaborative Research Team Jul 2021

Physical Activity Among Adults Residing In 11 Countries During The Covid-19 Pandemic Lockdown, Kele Ding, Jingzhen Yang, Ming-Kai Chin, Lindsay Sullivan, J. Larry Durstine, Verónica Violant-Holz, Giyasettin Demirhan, Nara R.C. Oliveira, Biljana Popeska, Garry Kuan, Waheeda Khan, Jianhui Dai, Xia Xu, Zornitza Mladenova, Govindasamy Balasekaran, Gary A. Smith, Global Community Health-Covid-19 Collaborative Research Team

Faculty Publications

During the novel coronavirus (COVID-19) pandemic, physical activity (PA) behaviors were altered worldwide due to public health measures such as “lockdown.” This study described PA among adults residing in 11 countries during COVID-19 lockdown and examined factors associated with PA engagement. We conducted a cross-sectional anonymous survey among adults (≥18 years old) in 11 countries (Brazil, Bulgaria, China, India, Ireland, Malaysia, North Macedonia, Singapore, Spain, Turkey, United States). Of 11,775 participants, 63.7% were female and 52.8% were 18–34 years old. More than 40% of participants were insufficiently active (43.9%) and reported a decrease in their PA during lockdown (44.8%). Statistically …


Comparative Antennal Morphometry And Sensilla Organization In The Reproductive And Non-Reproductive Castes Of The Formosan Subterranean Termite, Paula Castillo, Nathan Le, Qian Sun Jul 2021

Comparative Antennal Morphometry And Sensilla Organization In The Reproductive And Non-Reproductive Castes Of The Formosan Subterranean Termite, Paula Castillo, Nathan Le, Qian Sun

Faculty Publications

Antennae are the primary sensory organs in insects, where a variety of sensilla are distributed for the perception of the chemical environment. In eusocial insects, colony function is main-tained by a division of labor between reproductive and non-reproductive castes, and chemosensation is essential for regulating their specialized social activities. Several social species in Hymenoptera display caste-specific characteristics in antennal morphology and diversity of sensilla, reflecting their differential tasks. In termites, however, little is known about how the division of labor is associated with chemosensory morphology among castes. Using light and scanning electron microscopy, we performed antennal morphometry and characterized the …


Changes In The Microbial Community In Soybean Plots Treated With Biochar And Poultry Litter, Rosalie B. Calderon, Changyoon Jeong, Hyun Hwoi Ku, Lyndon M. Coghill, Young Jeong Ju, Nayong Kim, Jong Hyun Ham Jul 2021

Changes In The Microbial Community In Soybean Plots Treated With Biochar And Poultry Litter, Rosalie B. Calderon, Changyoon Jeong, Hyun Hwoi Ku, Lyndon M. Coghill, Young Jeong Ju, Nayong Kim, Jong Hyun Ham

Faculty Publications

The application of organic materials that promote beneficial microbial activity is vital to maintaining soil health and crop productivity. We investigated the effect on the soil microbiome of applying biochar (BC), poultry litter (PL), and a combination of biochar and poultry litter (BC/PL) in soybean cultivation at the Red River Research Station (Bossier City, LA, USA). We characterized the microbial profiles, community structure, and co-occurrence network from sequencing data to infer microbial interactions in the soil samples collected in the first and second years of each soil treatment (2016 and 2017, respectively). Our results showed that soil treatments with BC, …


The Aortic-Femoral Arterial Stiffness Gradient: An Atherosclerosis Risk In Communities (Aric) Study, Keeron Stone, Simon Fryer, Michelle L. Meyer, Anna Kucharska-Newton, James Faulkner, Gabriel Zieff, Craig Paterson, Daniel Credeur, Kunihiro Matsushita, Timothy M. Hughes, Hirofumi Tanaka, Lee Stoner Jul 2021

The Aortic-Femoral Arterial Stiffness Gradient: An Atherosclerosis Risk In Communities (Aric) Study, Keeron Stone, Simon Fryer, Michelle L. Meyer, Anna Kucharska-Newton, James Faulkner, Gabriel Zieff, Craig Paterson, Daniel Credeur, Kunihiro Matsushita, Timothy M. Hughes, Hirofumi Tanaka, Lee Stoner

Faculty Publications

Background: The aortic to femoral arterial stiffness gradient (af-SG) may be a novel measure of arterial health and cardiovascular disease (CVD) risk, but its association with CVD risk factors and CVD status, and whether or not they differ from the referent measure, carotid-femoral pulse-wave velocity (cfPWV), is not known.

Method: Accordingly, we compared the associations of the af-SG and cfPWV with (i) age and traditional CVD risk factors and (ii) CVD status. We evaluated 4183 older-aged (75.2 ± 5.0 years) men and women in the community-based Atherosclerosis Risk in Communities (ARIC) Study. cfPWV and femoral-ankle PWV (faPWV) were …


Stable Isotope Analyses Identify Trophic Niche Partitioning Between Sympatric Terrestrial Vertebrates In Coastal Saltmarshes With Differing Oiling Histories, Sydney Moyo, Hayat Bennadji, Danielle Laguaite, Anna A. Pérez-Umphrey, Allison M. Snider, Andrea Bonisoli-Alquati, Jill A. Olin, Philip C. Stouffer, Sabrina S. Taylor, Paola C. López-Duarte, Brian J. Roberts, Linda Hooper-Bui, Michael J. Polito Jul 2021

Stable Isotope Analyses Identify Trophic Niche Partitioning Between Sympatric Terrestrial Vertebrates In Coastal Saltmarshes With Differing Oiling Histories, Sydney Moyo, Hayat Bennadji, Danielle Laguaite, Anna A. Pérez-Umphrey, Allison M. Snider, Andrea Bonisoli-Alquati, Jill A. Olin, Philip C. Stouffer, Sabrina S. Taylor, Paola C. López-Duarte, Brian J. Roberts, Linda Hooper-Bui, Michael J. Polito

Faculty Publications

Bioindicator species are commonly used as proxies to help identify the ecological effects of oil spills and other stressors. However, the utility of taxa as bioindicators is dependent on understanding their trophic niche and life history characteristics, as these factors mediate their ecological responses. Seaside sparrows (Ammospiza maritima) and marsh rice rats (Oryzomys palustris) are two ubiquitous terrestrial vertebrates that are thought to be bioindicators of oil spills in saltmarsh ecosystems. To improve the utility of these omnivorous taxa as bioindicators, we used carbon and nitrogen stable isotope analysis to quantify their trophic niches at saltmarshes in coastal Louisiana with …


Molecular Evolution Of Ecological Specialisation: Genomic Insights From The Diversification Of Murine Rodents, Emily Roycroft, Anang Achmadi, Colin M. Callahan, Jacob A. Esselstyn, Jeffrey M. Good, Adnan Moussalli, Kevin C. Rowe Jul 2021

Molecular Evolution Of Ecological Specialisation: Genomic Insights From The Diversification Of Murine Rodents, Emily Roycroft, Anang Achmadi, Colin M. Callahan, Jacob A. Esselstyn, Jeffrey M. Good, Adnan Moussalli, Kevin C. Rowe

Faculty Publications

Adaptive radiations are characterized by the diversification and ecological differentiation of species, and replicated cases of this process provide natural experiments for understanding the repeatability and pace ofmolecular evolution.During adaptive radiation, genes related to ecological specialization may be subject to recurrent positive directional selection. However, it is not clear to what extent patterns of lineage-specific ecological specialization (includingphenotypic convergence) are correlatedwithsharedsignatures of molecular evolution. To test this, we sequenced whole exomes from a phylogenetically dispersed sample of 38 murine rodent species, a group characterized bymultiple, nested adaptive radiations comprising extensive ecological and phenotypic diversity.We found that genes associatedwithimmunity, reproduction, diet, …


Individual Quality And Phenology Mediate The Effect Of Radioactive Contamination On Body Temperature In Chernobyl Barn Swallows, Zbyszek Boratynski, Timothy A. Mousseau, Anders Pape Moller Jul 2021

Individual Quality And Phenology Mediate The Effect Of Radioactive Contamination On Body Temperature In Chernobyl Barn Swallows, Zbyszek Boratynski, Timothy A. Mousseau, Anders Pape Moller

Faculty Publications

Anthropogenic stressors, such as radioactive contaminants released from the Chernobyl and Fukushima Daiichi accidents, deteriorate ecological and evolutionary processes, as evidence for damaging effects of radioactive contamination on wildlife is accumulating. Yet little is known about physiological traits of animals inhabiting contaminated areas, and how those are affected by individual quality and phenology. We investigated variation in body temperature of wild barn swallows, Hirundo rustica, exposed to radioactive contamination from the Chernobyl accident in Ukraine and Belarus. We tested whether exposure to variable levels of radioactive contamination modified core body temperature of birds, and whether individual and phenological characteristics modulated …


Closed-Form Solution For Shock Wave Propagation In Density-Graded Cellular Material Under Impact, Vjendra Gupta, Addis Kidane, Michael A. Sutton Jul 2021

Closed-Form Solution For Shock Wave Propagation In Density-Graded Cellular Material Under Impact, Vjendra Gupta, Addis Kidane, Michael A. Sutton

Faculty Publications

Density-graded cellular materials have tremendous potential in structural applications where impact resistance is required. Cellular materials subjected to high impact loading result in a compaction type deformation, usually modeled using continuum-based shock theory. The resulting governing differential equation of the shock model is nonlinear, and the density gradient further complicates the problem. Earlier studies have employed numerical methods to obtain the solution. In this study, an analytical closed-form solution is proposed to predict the response of density-graded cellular materials subjected to a rigid body impact. Solutions for the velocity of the impinging rigid body mass, energy absorption capacity of the …


Rabies Postexposure Prophylaxis In The United States: Opportunities To Improve Access, Coordination, And Delivery, Gavin T. Howington, Huy-Binh Nguyen, P Brandon Bookstaver, Peter Akpunonu, Joshua T. Swan Jul 2021

Rabies Postexposure Prophylaxis In The United States: Opportunities To Improve Access, Coordination, And Delivery, Gavin T. Howington, Huy-Binh Nguyen, P Brandon Bookstaver, Peter Akpunonu, Joshua T. Swan

Faculty Publications

No abstract provided.


Deference Is Dead, Long Live Chevron, Nathan D. Richardson Jul 2021

Deference Is Dead, Long Live Chevron, Nathan D. Richardson

Faculty Publications

Chevron v. NRDC has stood for more than 35 years as the central case on judicial review of administrative agencies’ interpretations of statutes. Its contours have long been debated, but more recently it has come under increasing scrutiny, with some—including two sitting Supreme Court Justices—calling for the case to be overturned. Others praise Chevron, calling deference necessary or even inevitable. All seem to agree the doctrine is powerful and important.

This standard account is wrong, however. Chevron is not the influential doctrine it once was and has not been for a long time. It has been eroded from the outside …


Blockumulus: A Scalable Framework For Smart Contracts On The Cloud, Nikolay Ivanov, Qiben Yan, Qingyang Wang Jul 2021

Blockumulus: A Scalable Framework For Smart Contracts On The Cloud, Nikolay Ivanov, Qiben Yan, Qingyang Wang

Faculty Publications

Public blockchains have spurred the growing popularity of decentralized transactions and smart contracts, especially on the financial market. However, public blockchains exhibit their limitations on the transaction throughput, storage availability, and compute capacity. To avoid transaction gridlock, public blockchains impose large fees and per-block resource limits, making it difficult to accommodate the ever-growing high transaction demand. Previous research endeavors to improve the scalability and performance of blockchain through various technologies, such as side-chaining, sharding, secured off-chain computation, communication network optimizations, and efficient consensus protocols. However, these approaches have not attained a widespread adoption due to their inability in delivering a …


Evaluation Of Circulating Levels Of Interleukin-10 And Interleukin-16 And Dietary Inflammatory Index In Lebanese Knee Osteoarthritis Patients, Zeina El-Ali, Germine El-Kassas, Fouad M. Ziade, Nitin Shivappa Mbbs, Mph, Ph.D., James Hébert Scd, Nisrine Bissar Jul 2021

Evaluation Of Circulating Levels Of Interleukin-10 And Interleukin-16 And Dietary Inflammatory Index In Lebanese Knee Osteoarthritis Patients, Zeina El-Ali, Germine El-Kassas, Fouad M. Ziade, Nitin Shivappa Mbbs, Mph, Ph.D., James Hébert Scd, Nisrine Bissar

Faculty Publications

Objectives

To investigate plasma concentrations of Interleukin-16 (IL-16) and Interleukin-10 (IL-10) in Lebanese knee osteoarthritis (KOA) patients and to examine the association between the diet-associated inflammation and increased risk for KOA.

Methods

A total of 208 study participants were assigned to one of the 3 groups: Diagnosed Knee Osteoarthritis group (DKOA) (N = 78); Undiagnosed Knee Osteoarthritis group (UKOA) (N = 60) and controls matched on age, sex and sociodemographic characteristics (N = 70). UKOA represents KOA features before they are altered by therapeutic intervention and lifestyle modifications that follow the diagnosis. Energy-adjusted dietary inflammatory index (E-DII™) scores were calculated …


Strategic Human Resource Management And Covid-19: Emerging Challenges And Research Opportunities, David G. Collings, John Mcmackin, Anthony Nyberg, Patrick M. Wright Jul 2021

Strategic Human Resource Management And Covid-19: Emerging Challenges And Research Opportunities, David G. Collings, John Mcmackin, Anthony Nyberg, Patrick M. Wright

Faculty Publications

No abstract provided.


Perspective: The Importance Of Water Security For Ensuring Food Security, Good Nutrition, And Well-Being, Sera L. Young, Edward A. Frongillo Jr., Zeina Jamaluddine, Hugo Melgar-Quiñonez, Rafael Pérez-Escamilla, Claudia Ringler, Asher Y. Rosinger Jul 2021

Perspective: The Importance Of Water Security For Ensuring Food Security, Good Nutrition, And Well-Being, Sera L. Young, Edward A. Frongillo Jr., Zeina Jamaluddine, Hugo Melgar-Quiñonez, Rafael Pérez-Escamilla, Claudia Ringler, Asher Y. Rosinger

Faculty Publications

Water security is a powerful concept that is still in its early days in the field of nutrition. Given the prevalence and severity of water issues and the many interconnections between water and nutrition, we argue that water security deserves attention commensurate with its importance to human nutrition and health. To this end, we first give a brief introduction to water insecurity and discuss its conceptualization in terms of availability, access, use, and stability. We then lay out the empirical grounding for its assessment. Parallels to the food-security literature are drawn throughout, both because the concepts are analogous and food …


Comparing Dietary Score Associations With Lipoprotein Particle Subclass Profiles: A Cross-Sectional Analysis Of A Middle-To Older-Aged Population, Seán R. Millar, Pilar Navarro, Janas M. Harrington, Nitin Shivappa Mbbs, Mph, Ph.D., James Hébert Scd, Ivan J. Perry, Catherine M. Phillips Jul 2021

Comparing Dietary Score Associations With Lipoprotein Particle Subclass Profiles: A Cross-Sectional Analysis Of A Middle-To Older-Aged Population, Seán R. Millar, Pilar Navarro, Janas M. Harrington, Nitin Shivappa Mbbs, Mph, Ph.D., James Hébert Scd, Ivan J. Perry, Catherine M. Phillips

Faculty Publications

Background and objectives: Lipoprotein particle concentrations and size are associated with increased risk for atherosclerosis and premature cardiovascular disease. Studies also suggest that certain dietary behaviours may be cardioprotective. Limited comparative data regarding any dietary score/index-lipoprotein particle subclass associations exist. Thus, our objective was to assess relationships between the Dietary Approaches to Stop Hypertension (DASH), Health Eating Index-2015 (HEI-2015), Mediterranean Diet (MD) and Energy-adjusted Dietary Inflammatory Index (E-DII™) scores and plasma lipids and lipoprotein profiles to test the hypothesis that healthier diet (better quality and more anti-inflammatory) would be associated with a more favourable lipoprotein profile.

Materials and methods: This …


Vaccination: Biblical-Theological Reflection, Jiří Moskala Jul 2021

Vaccination: Biblical-Theological Reflection, Jiří Moskala

Faculty Publications

No abstract provided.


A Qualitative Study Of Stress And Coping To Inform The Leads Health Promotion Trial For African American Adolescents With Overweight And Obesity, Mary Quattlebaum, Colby Kipp, Dawn Wilson-King, Allison Sweeney Ph.D. Jun 2021

A Qualitative Study Of Stress And Coping To Inform The Leads Health Promotion Trial For African American Adolescents With Overweight And Obesity, Mary Quattlebaum, Colby Kipp, Dawn Wilson-King, Allison Sweeney Ph.D.

Faculty Publications

The purpose of this study was to conduct in-depth individual interviews with 30 African American adolescents with overweight and obesity and their families (caregiver/adolescent dyads) to gain a better understanding of how to integrate stress and coping essential elements into an existing family-based health promotion program for weight loss. Interview data from 30 African American adolescents with overweight and obesity (Mage = 15.30 ± 2.18; MBMI%-ile = 96.7 ± 3.90) were transcribed and coded for themes using inductive and deductive approaches by two independent coders. Inter-rater reliability was acceptable (r = 0.70–0.80) and discrepancies were resolved to 100% agreement. The …


An Evidence-Based Review Of The Pathophysiology, Treatment, And Prevention Of Exercise-Associated Muscle Cramps, Kevin C. Miller, Brendon P. Mcdermott, Susan W. Yeargin, Aidan Fiol, Martin P. Schwellnus Jun 2021

An Evidence-Based Review Of The Pathophysiology, Treatment, And Prevention Of Exercise-Associated Muscle Cramps, Kevin C. Miller, Brendon P. Mcdermott, Susan W. Yeargin, Aidan Fiol, Martin P. Schwellnus

Faculty Publications

Exercise-associated muscle cramps (EAMCs) are common and frustrating for athletes and the physically active. We critically appraised the EAMC literature to provide evidence based treatment and prevention recommendations. Although the pathophysiology of EAMCs appears controversial, recent evidence suggests that EAMCs are due to a confluence of unique intrinsic and extrinsic factors rather than a singular cause. The treatment of acute EAMCs continues to include self-applied or clinician-guided gentle static stretching until symptoms abate. Once the painful EAMCs are alleviated, the clinician can continue treatment on the sidelines by focusing on patient-specific risk factors that may have contributed to the onset …


Risk Of Early-Onset Dementia Among Persons With Tinnitus: A Retrospective Case–Control Study, Yen-Fu Cheng, Sudha Xirasagar Mbbs. Ph.D., Tzong- Han Yang, Chuan-Song Wu, Yi-Wei Kao, Herng-Ching Lin Jun 2021

Risk Of Early-Onset Dementia Among Persons With Tinnitus: A Retrospective Case–Control Study, Yen-Fu Cheng, Sudha Xirasagar Mbbs. Ph.D., Tzong- Han Yang, Chuan-Song Wu, Yi-Wei Kao, Herng-Ching Lin

Faculty Publications

Higher rates of poor cognitive performance are known to prevail among persons with tinnitus in all age groups. However, no study has explored the association between tinnitus and early-onset dementia. We hypothesize that tinnitus may precede or occur concurrently with subclinical or early onset dementia in adults younger than 65 years of age. This case–control study used data from the Taiwan National Health Insurance Research Database, identifying 1308 patients with early-onset dementia (dementia diagnosed before 65 years of age) and 1308 matched controls. We used multivariable logistic regressions to estimate odds ratios (ORs) for prior tinnitus among patients with dementia …


The Young Age And Plant-Based Diet Hypothesis For Low Sars-Cov-2 Infection And Covid-19 Pandemic In Sub-Saharan Africa, J N. Losso, M N. Losso, M Toc, J N. Inungu, J N. Losso Jun 2021

The Young Age And Plant-Based Diet Hypothesis For Low Sars-Cov-2 Infection And Covid-19 Pandemic In Sub-Saharan Africa, J N. Losso, M N. Losso, M Toc, J N. Inungu, J N. Losso

Faculty Publications

Since the outbreak of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that caused the coronavirus disease-19 (COVID-19), in December 2019, the infection has spread around the globe. Some of the risk factors include social distancing, mask wearing, hand washing with soap, obesity, diabetes, hypertension, asthma, cardiovascular disease, and dysbiosis. Evidence has shown the incidence of total infection and death rates to be lower in sub-Saharan Africa when compared with North Africa, Europe and North America and many other parts of the world. The higher the metabolic syndrome rate, the higher the risk of SARS-CoV-2 infection. Africa has a lower …


Review Of The Analysis Of 234Th In Small Volume (2–4 L) Seawater Samples: Improvements And Recommendations, Samantha J. Clevenger, Claudia Benitez-Nelson, Jessica Drysdale, Steven Pike, Viena Puigcorbé, Ken O. Buesseler Jun 2021

Review Of The Analysis Of 234Th In Small Volume (2–4 L) Seawater Samples: Improvements And Recommendations, Samantha J. Clevenger, Claudia Benitez-Nelson, Jessica Drysdale, Steven Pike, Viena Puigcorbé, Ken O. Buesseler

Faculty Publications

Schools may be one important context where adolescents learn and shape the behaviors necessary for promoting global inclusivity in adulthood. Given the importance of bystanders in halting bullying and peer aggression, the focus of this study is on both moral judgments regarding one type of bullying, social exclusion, and factors that are associated with bystander intervention. The study includes 896 adolescents, who were 6th (N = 450, Mage = 11.73), and 9th (N = 446, Mage = 14.82) graders, approximately evenly divided by gender. Participants were primarily European–American (63.3%). Results revealed that girls and participants who …


Clinical Correlations Of Polycomb Repressive Complex 2 In Different Tumor Types, Maksim Erokhin, Olga Chetverina, Balázs Győrffy, Victor V. Tatarskiy, Vladic Mogila, Alexander A. Shtil, Igor Roninson, Jerome Moreaux, Pavel Georgiev, Giacomo Cavalli, Darya Chetverina Jun 2021

Clinical Correlations Of Polycomb Repressive Complex 2 In Different Tumor Types, Maksim Erokhin, Olga Chetverina, Balázs Győrffy, Victor V. Tatarskiy, Vladic Mogila, Alexander A. Shtil, Igor Roninson, Jerome Moreaux, Pavel Georgiev, Giacomo Cavalli, Darya Chetverina

Faculty Publications

PRC2 (Polycomb repressive complex 2) is an evolutionarily conserved protein complex required to maintain transcriptional repression. The core PRC2 complex includes EZH2, SUZ12, and EED proteins and methylates histone H3K27. PRC2 is known to contribute to carcinogenesis and several small molecule inhibitors targeting PRC2 have been developed. The present study aimed to identify the cancer types in which PRC2 targeting drugs could be beneficial. We queried genomic and transcriptomic (cBioPortal, KMplot) database portals of clinical tumor samples to evaluate clinical correlations of PRC2 subunit genes. EZH2, SUZ12, and EED gene amplification was most frequently found in prostate cancer, whereas lymphoid …


Resistance Exercise, Alone And In Combination With Aerobic Exercise, And Obesity In Dallas, Texas, Us: A Prospective Cohort Study, Angelique G. Brellenthin, Duck-Chul Lee, Jason A. Bennie, Xuemei (Mei) Sui M.D., M.P.H., Ph.D., Steven N. Blair Jun 2021

Resistance Exercise, Alone And In Combination With Aerobic Exercise, And Obesity In Dallas, Texas, Us: A Prospective Cohort Study, Angelique G. Brellenthin, Duck-Chul Lee, Jason A. Bennie, Xuemei (Mei) Sui M.D., M.P.H., Ph.D., Steven N. Blair

Faculty Publications

Background

Obesity is a significant and growing public health problem in high-income countries. Little is known about the relationship between resistance exercise (RE), alone and in combination with aerobic exercise (AE), and the risk of developing obesity. The purpose of this prospective cohort study was to examine the associations between different amounts and frequencies of RE, independent of AE, and incident obesity.

Methods and findings

Participants were 11,938 healthy adults ages 18–89 years with a BMI < 30 kg/m2 at baseline who completed at least 2 clinical examinations during 1987–2005 as part of the Aerobics Center Longitudinal Study. Self-reported RE participation in minutes/week and days/week was collected from a standardized questionnaire. Incident obesity was defined as a BMI ≥ 30 kg/m2 at follow-up. Incident obesity was also defined by waist circumference (WC) > 102/88 cm for men/women and percent body fat (PBF) ≥ 25%/30% for men/women at follow-up in participants who were not obese by WC (n …


Topology And Ground State Control In Open-Shell Donor-Acceptor Conjugated Polymers, Kevin S. Mayer, Daniel J. Adams, Naresh Eedugurala, Molly M. Lockart, Paramasivam Mahalingavelar, Lifeng Huang, Luke A. Galuska, Eric R. King, Xiaodan Gu, Michael K. Bowman, Jason D. Azoulay Jun 2021

Topology And Ground State Control In Open-Shell Donor-Acceptor Conjugated Polymers, Kevin S. Mayer, Daniel J. Adams, Naresh Eedugurala, Molly M. Lockart, Paramasivam Mahalingavelar, Lifeng Huang, Luke A. Galuska, Eric R. King, Xiaodan Gu, Michael K. Bowman, Jason D. Azoulay

Faculty Publications

Donor-acceptor (DA) conjugated polymers (CPs) with narrow bandgaps and open-shell (diradical) character represent an emerging class of materials whose rich behavior emanates from their collective electronic properties and diminished electron pairing. However, the structural and electronic heterogeneities that define these materials complicate bandgap control at low energies and connections linking topology, exchange interactions, and (opto)electronic functionality remain nascent. To address these challenges, we demonstrate structurally rigid and strongly π-conjugated copolymers comprised of a solubilizing thiadiazoloquinoxaline acceptor and cyclopenta[2,1-b:3,4-b′]dithiophene or dithieno[3,2-b:2′,3′-d]thiophene donors. Atom-specific substitution modulates local aromatic character within the donor resulting in dramatic differences in structural, physicochemical, electronic, and magnetic …


Peer-To-Peer Health Promotion Interventions Among African American Men: A Scoping Review Protocol, Guillermo M. Wippold, Sarah Grace Frary, Demetrius Abshire Phd, Rn, Dawn Wilson-King Jun 2021

Peer-To-Peer Health Promotion Interventions Among African American Men: A Scoping Review Protocol, Guillermo M. Wippold, Sarah Grace Frary, Demetrius Abshire Phd, Rn, Dawn Wilson-King

Faculty Publications

Background

Health promotion efforts among African American men have been met with significant challenges and have produced limited results. Interventions that do not align with the values, perspectives, and preferences of African American men often produce less effective results. Research among African American men has provided compelling evidence that these men prefer informal networks of health support. Recent successful health promotion efforts among these men have benefited from peer-to-peer models of implementation. To date, no known scoping or systematic review of peer-to-peer health promotion interventions among African American men has been conducted. The goal of this scoping review is to …


The Community Health Worker (Chw) Common Indicators Project: Engaging Chws In Measurement To Sustain The Profession, Keara Rodela, Noelle Wiggins, Kenneth Maes, Teresa Campos-Dominguez, Victoria Adewumi, Pennie Jewell, Susan Mayfield-Johnson Jun 2021

The Community Health Worker (Chw) Common Indicators Project: Engaging Chws In Measurement To Sustain The Profession, Keara Rodela, Noelle Wiggins, Kenneth Maes, Teresa Campos-Dominguez, Victoria Adewumi, Pennie Jewell, Susan Mayfield-Johnson

Faculty Publications

Despite progress in documenting the outcomes of Community Health Worker interventions, the lack of standardized measures to assess CHW practice has made it difficult for programs to conduct reliable evaluations, and impossible to aggregate data across programs and regions, impeding commitment to sustainable, long-term financing of CHW programs. In addition, while CHWs have sometimes been involved as data collectors, they have seldom been engaged as full partners in all stages of evaluation and research. This manuscript details the current work being done by the CI Project, demonstrating how CHWs are able to contribute to the integrity, sustainability, and viability of …


The Mexico Simsmoke Tobacco Control Policy Model: Development Of A Simulation Model Of Daily And Nondaily Cigarette Smoking, Luz Maria Sanchez-Romero, Luis Zavala-Arciniega, Luz Myriam Reynales-Shigematsu, Belén Sáenz De Miera-Juárez, Zhe Yuan, Yameng Li, Yan Kwan Lau, Nancy L. Fleischer, Rafael Meza, Jim F. Thrasher Ph.D., Ma, Ms, David T. Levy Jun 2021

The Mexico Simsmoke Tobacco Control Policy Model: Development Of A Simulation Model Of Daily And Nondaily Cigarette Smoking, Luz Maria Sanchez-Romero, Luis Zavala-Arciniega, Luz Myriam Reynales-Shigematsu, Belén Sáenz De Miera-Juárez, Zhe Yuan, Yameng Li, Yan Kwan Lau, Nancy L. Fleischer, Rafael Meza, Jim F. Thrasher Ph.D., Ma, Ms, David T. Levy

Faculty Publications

Background

Nondaily smoking has been on the rise, especially in Mexico. While Mexico has strengthened its tobacco control policies, their effects on nondaily smokers have gone largely unexamined. We developed a simulation model to estimate the impact of tobacco control policies on daily and nondaily smoking in Mexico.

Methods

A previously validated Mexico SimSmoke model that estimated overall trends in smoking prevalence from 2002 through 2013 was extended to 2018 and adapted to distinguish daily and nondaily smoking prevalence. The model was then validated using data from Mexican surveys through 2016. To gauge the potential effects of policies, we compared …


Time Spent In Different Sedentary Activity Domains Across Adolescence: A Follow-Up Study, Michael Pereira Silva, Roseane De Guimarães, Eliane Denise Bacil, Thiago Silva Piola, Edmar Roberto Fantinelli, Fabio Eduardo Fontana, Wagner De Campos Jun 2021

Time Spent In Different Sedentary Activity Domains Across Adolescence: A Follow-Up Study, Michael Pereira Silva, Roseane De Guimarães, Eliane Denise Bacil, Thiago Silva Piola, Edmar Roberto Fantinelli, Fabio Eduardo Fontana, Wagner De Campos

Faculty Publications

OBJECTIVE: This longitudinal study aimed to verify possible changes in the time spent in sedentary activities occurring as screen-time, educational, cultural, social, and transportation domains in a sample of Brazilian adolescents between 2015 and 2017.

METHODS: It is a longitudinal prospective study with 586 adolescents from 12 to 15 years old at the Baseline (2015) enrolled in 14 public schools from Curitiba, Brazil. The Adolescent Sedentary Activity Questionnaire assessed the time spent in sedentary activities in five domains (recreational screen-time, educational, cultural, social, and transportation). A series of linear random effects regressions analyzed changes in the sedentary time between 2015 …