Digital Commons Network^™

Phenome-Wide Association Study Of P2rx7 Identifies Schizophrenia And Mood Disorders As Primary Associated Phenotypes, Ling Zhu, Qiao Mao, Zhixiong Luo, Bin Chen, Yong Zhang, Xiaowei Lu, Ping Liu, Jiawu Ji, Xiaoping Wang, Kesheng Wang Phd, Ma, Bs, Xinghua Pan, Yuping Cao, Na Liu, Jennifer Luo, Lingjun Zuo, Zhiren Wang, Xingguang Luo, Xiaoyun Guo

Faculty Publications

Objectives: P2RX7 has been implicated in bipolar disorder, major depressive disorder, schizophrenia, anxiety disorders, Alzheimer's disease, and Parkinson's disease. However, the specificity and comparability of these as sociations remain unclear. This study aimed to systematically evaluate multiple neuropsychiatric disorders to identify those most robustly associated with P2RX7.

Methods: We analyzed 1861 imputed SNPs spanning the P2RX7 gene in 1,087,925 individuals from 72 inde pendent cohorts across 18 neuropsychiatric disorders. SNP-disease associations were assessed within each cohort, followed by meta-analysis and false discovery rate (FDR) correction to identify significant disease-risk variants. P2RX7 mRNA and protein expression across tissues or cells …

Does Patient History Influence Capsular Contracture? An Exploratory Analysis With Machine Learning, Thomas M. Johnstone, Daniel Najafali, Jennifer K. Shaw, Justin M. Camacho, Chancellor Johnstone, Rahim S. Nazerali, Gordon K. Lee

Faculty Publications

Background: Capsular contracture (CC) is a frequent and distressing complication of breast augmentation and reconstruction. Although numerous patient-, surgical-, and implant-related risk factors have been proposed, reliable population-level predictors remain inconsistent across studies. This study evaluates whether administrative medical history, as encoded by ICD and CPT codes, contains sufficient predictive signal to identify patients at risk for CC using machine learning. Methods: Patients were queried from the MerativeTM MarketScan® Research Databases from 2003 to 2017 with CPT codes for implant-based breast reconstruction and augmentation. ICD codes were then used to identify all events and conditions of a patient’s history. Hyperparameter-tuned …

Panda-Plus-Bench: A Clinical Benchmark For Evaluating The Robustness Of Ai Foundation Models In Prostate Cancer Diagnosis, Joshua L. Ebbert, Dennis Della Corte

Faculty Publications

Artificial intelligence foundation models are increasingly deployed for prostate cancer Gleason grading, where GP3/GP4 distinction directly impacts treatment decisions (active surveillance vs. intervention). However, these models may achieve high validation accuracy by learning specimen-specific artifacts rather than generalizable biological features, limiting real-world clinical utility. We introduce PANDA-PLUS-Bench, a curated benchmark dataset derived from expertly annotated prostate biopsies designed specifically to quantify this failure mode. The benchmark comprises nine carefully selected whole slide images from nine unique patients containing diverse Gleason patterns, with non-overlapping tissue patches extracted at both 512 × 512 and 224 × 224-pixel resolutions across eight augmentation conditions. …

The Meaning And Measurement Of Unrealised Fertility: A Comparison Of Measures Among Women Ages 40-49 In The United States, Kathleen Broussard

Faculty Publications

Unrealised fertility – when people fall short of their childbearing goals – is inconsistently defined and measured, leading to wide variation in estimates of its prevalence and implications for health and well-being. Using a nationally representative sample of U.S. women aged 40–49, this study compares four potential approaches to measurement, finding prevalence estimates that range from 3.5% to 22.4% across indicators. Multivariable logistic regression models reveal that the social and reproductive health correlates of unrealised fertility also vary according to the selected indicator. Improved measures of unrealised fertility are needed to inform our understanding of fertility barriers, including who is …

Modeling Individual Self-Protective Behavior During Epidemics, Geonsik Yu, Michael J. Garee, Mario Ventresca, Yuehwern Yih

Faculty Publications

Protecting public health from infectious diseases requires collective action, as individual behaviors—such as vaccination and mask-wearing—directly influence disease dynamics. During the COVID-19 pandemic, unexpected public responses often undermined the effectiveness of interventions, highlighting the need to understand collective behavioral patterns and motivations to design more effective mitigation strategies. This study presents an agent-based simulation model that captures how individuals adjust self-protective behaviors based on evolving opinions about disease risk and examines how these decisions interact with external factors, such as public health interventions, to shape collective outcomes. To improve the representativeness of the simulated population, multiple datasets were integrated to …

Systematic Reviews Across Disciplines: Comparing Quality And Publication Practices, Megan Bresnahan, Eugenia Opuda

Faculty Publications

As the publication of systematic reviews has proliferated across the sciences in the past decade, librarians have a role in helping researchers select the appropriate type of review, providing best practice guidelines, and under-standing variations in disciplinary practices for evidence synthesis. Using a title-abstract search filtered by 10 research areas in the Web of Science, we collected a sample of 100 systematic reviews from a range of disciplines, including “Fisheries,” “Forestry,” “Health Care Sciences & Services,” and “Veterinary Sciences.” Our analysis of this data explores to what extent these articles include the basic components of a systematic review and adhere …

Sequence Determinants Of Rna G-Quadruplex Unfolding By Arg-Rich Regions, Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui-Ting Lee, Jun Zhang

Faculty Publications

RNA sequences with the potential to form G-quadruplexes (rGQs) are widespread but largely unfolded in cells by unknown mechanisms. rGQ folding status is a critical regulator of RNA splicing and translation. We show that rGQs can be unfolded by SR proteins, SR-related proteins, and other Arg-rich proteins, including SRSF1, SRSF3, SRSF9, U1-70K, and U2AF1. The length and composition of Arg-rich regions are key determinants of this activity: Arg residues are the primary drivers, while acidic residues attenuate the unfolding activity. To unfold ARPC2 rGQ, at least 13 Arg residues are required. Our findings identify Arg-rich proteins as previously unrecognized, helicase-independent …

Association Between Cholinesterase Inhibitor-Overactive Bladder Antimuscarinic Prescribing Cascade And Risk Of Delirium And Falls Among Individuals Living With Dementia, Sarah Beth Tucker, Bryan L. Love Pharm D., Chijoke M. Okeke, Erin D. Zwick, Chengwen Teng Pharm.D., Ph.D., Jingkai Wei, Ibraheem M. Karaye, Saud Alsahali, Krithika Rajagopalan, Ismaeel Yunusa Ph.D.

Faculty Publications

Background

Prescribing cascades occur when cholinesterase inhibitor (ChEI)-induced urinary incontinence is misinterpreted as a new condition, leading to overactive bladder (OAB) antimuscarinic initiation. We evaluated whether the ChEI-OAB antimuscarinic prescribing cascade was associated with delirium or falls compared with mirabegron in older adults living with dementia.

Methods

We conducted a retrospective cohort study using the Anlitiks All-Payor Claims database (2015–2020). Participants were adults aged ≥ 65 years with dementia newly prescribed a ChEI with no prior ChEI or OAB therapy (180 days). A 60-day window identified OAB treatment initiation after ChEI therapy. Exposures were OAB antimuscarinics or mirabegron. Outcomes were …

Increasing Pride Skills For Child Engagement Using Cdi-Only Ipcit With Children With Autism Spectrum Disorder, Jordan T. Etherington, Zachary C. Labrot, Emily R. Defouw, Brad Dufrene, Brittany D. Garza, Amarah Sweaks, Briley Newcomb

Faculty Publications

Many children with autism spectrum disorder (ASD) display elevated levels of challenging behaviors and decreased social engagement. Parent Child Interaction Therapy (PCIT) may help children with ASD increase rates at which they engage and interact with their caregivers. Existing barriers to treatment completion, including high attrition and travel time and costs, may be ameliorated by delivering PCIT virtually (iPCIT) and setting attainable mastery criteria. This study utilized a multiple baseline design across three caregiver-child dyads with ASD to determine whether an iPCIT protocol affected caregivers’ use of positive engagement skills, children’s engagement, and children’s challenging behaviors. Results demonstrated increased and …

Use Of Period- Or Fertility-Tracking Technologies Pre- And Post-Dobbs, Emily Neiman, Marta Bornstein Phd, Mph, Abigail Norris Turner, Megan L. Kavanaugh, Maria F. Gallo

Faculty Publications

Objectives

Study design

Statutory Backups For Endangered Constitutional Rights, Aaron-Andrew P. Bruhl

Faculty Publications

This Article concerns the phenomenon of “statutory backup rights,” or statutes that provide protections parallel to constitutional rights that are believed to be at risk of judicial abrogation. Proposals for backup rights gained attention in the aftermath of the Supreme Court’s 2022 decision in Dobbs v. Jackson Women’s Health Organization, which not only eliminated the constitutional right to abortion but called into question some other constitutional rights as well. Shortly after Dobbs, Congress enacted a limited statutory backup for same-sex marriage. States have created backup rights across a range of topics, some of which appeal mostly to those …

Examining The Psychometric Structure Of An Instrument To Measure Students’ Interests And Motivation In Science Learning: Factor Analysis And Measurement Invariance, Fuhui Tong, Shifang Tang, Zhuoying Wang, Beverly J. Irby

Faculty Publications

In this study, we examined the psychometric properties (reliability, validity, and underlying factor structure) and measurement invariance of a researcher-developed instrument: Motivated Strategies for Science Learning (MSSL). Data were collected from 2765 fifth-grade students across [state withheld] school districts. Results from exploratory and confirmatory factor analyses suggested satisfactory psychometric properties of MSSL. We further identified strong evidence to support configural, metric, scalar, and strict invariance across school location groups (i.e., rural and non-rural), confirming that the instrument can accurately capture the construct of science learning motivation among fifth-grade students from both rural and non-rural Texas schools. The study provides the …

The Big Five Personality Traits And Perceptions Of Generative Ai In Higher Education: A Canonical Correlation Analysis For Sustainable Digital Education, Mei Jiang, Shifang Tang, Qingwei Wang

Faculty Publications

The purpose of this study was to examine the multivariate relationship between college students’ Big Five personality traits and their perceptions of generative artificial intelligence (AI). Guided by sustainable digital education and expectancy-value theory, this study investigated whether personality profiles were associated with students’ knowledge of AI, attainment value, intrinsic value, utility value, perceived cost, and intention to use AI. Using a cross-sectional survey design, data were collected from 375 students enrolled at a Southwestern doctoral-granting public university. Participants completed an adapted measure of generative AI perceptions and the Big Five Inventory, and canonical correlation analysis (CCA) was conducted to …

Libraries And Librarians Get After Participatory Science, Catherine Wong, Megan Bresnahan

Faculty Publications

No abstract provided.

Planning For The Transition To Adulthood: Parent Perspectives On The Planning Process And Experiences Of Young Adults With Fragile X Syndrome, Leonard Abbeduto, Jessica Klusek, Julie Lounds Taylor, Angela John Thurman

Faculty Publications

Objectives Relatively few young adults with fragile X syndrome (FXS) meet the normative expectations of adulthood, although there is heterogeneity in this regard. The present study examined the preparation for the transition to adulthood experienced by young adults with FXS and their parents.

Methods Thirty-nine young adults with FXS and their primary caregiving parents participated. Those with FXS were in their last year of, or had recently left, high school or a formal transition program. Parents completed surveys about the formal transition planning process. We examined the role of the young adults’ adaptive behavior skills in transition planning.

Results Among …

Planning For The Transition To Adulthood: Parent Perspectives On The Planning Process And Experiences Of Young Adults With Fragile X Syndrome, Leonard Abbeduto, Jessica Klusek Ph.D., Ccc-Slp, Julie Lounds Taylor, Angela John Thurman

Faculty Publications

Objectives

Relatively few young adults with fragile X syndrome (FXS) meet the normative expectations of adulthood, although there is heterogeneity in this regard. The present study examined the preparation for the transition to adulthood experienced by young adults with FXS and their parents.

Methods

Thirty-nine young adults with FXS and their primary caregiving parents participated. Those with FXS were in their last year of, or had recently left, high school or a formal transition program. Parents completed surveys about the formal transition planning process. We examined the role of the young adults’ adaptive behavior skills in transition planning.

Results

Among …

Changes In Depression, Eating, Sleep, And Emotion Regulation In Air Force Rotc Cadets After The 12-Wk Star Training Program, Antonella V. Schwarz, Hunter Haynes, Sheena Puleali’I, Jacob Mota, Molly F. Johnson, Maria G. Kaylor, Andrew Addison, Robyn Braun-Trocchio, Austin J. Graybeal

Faculty Publications

Introduction: – Reserve Officer Training Corps (ROTC) cadets must balance collegiate demands with military preparation, leaving them vulnerable to psychological stressors. While structured strength and conditioning (S&C) programs enhance physical readiness, their impact on psychological health in cadet populations remains unclear. This study evaluated changes in depression, eating behaviors, sleep quality, and emotion regulation during a 12-wk S&C program. Methods: – Forty-nine U.S. Air Force ROTC cadets (21 female, 28 male; age: 20 ± 2 yr; body mass index: 24.2 ± 4.4 kg·m⁻²; body fat %: 27.1 ± 9.0%) completed the Supporting Tactical Athlete Readiness (STAR) program, a …

Psychosocial Mediators Of A Physical Activity And Dietary Intervention In Pregnant Women With Overweight Or Obesity, Meghan Baruth, Sarah Wilcox, Jihong Liu, Rebecca Schlaff

Faculty Publications

Background

Mediation analyses provide insight into both ‘pieces’ of the mediation chain; they allow us to look into the ‘black box’ that is behavior change. They allow researchers to better understand the ‘how’ of an intervention’s effects and/or the ‘why’ behind why an intervention worked or did not work. The lack of publications in pregnant populations highlights the need for additional studies to be conducted and published. The purpose of this study is to examine the psychosocial mediators of physical activity and dietary outcomes in a sample of pregnant women with overweight or obesity participating in the Health in Pregnancy …

A Place To Breathe: High School Students’ Perceptions Of A School-Based Wellness Center, Devan Clayton, Elizabeth Cutrer, Paul Caldarella, Michael Richardson, Jared Warren

Faculty Publications

Adolescents face significant academic and emotional stressors, underscoring the need for accessible school-based mental health support. This qualitative study examined high school students’ (N = 17) perceptions of a school-based wellness center, including both users and non-users. Four focus groups were analyzed using Interpretative Phenomenological Analysis to explore experiences, perceived benefits, and barriers to use. Students described the center as a calming, supportive space that aided emotional regulation, short-term recovery, and readiness to return to class. Users emphasized relational connection, belonging, and managing stress and anxiety in a safe, nonjudgmental environment. Students also viewed the center as fostering early …

Riparian Ecosystem Condition And Impaired Floodplain Assessment In The Congaree River Watershed, South Carolina, Olusola-Ige O. Adetoro, Cuizhen Wang, Ayobami T. Salami, Olusegun O. Awotoye

Faculty Publications

Floodplain riparian ecological zones (FREZs) are transitional environments that facilitate interactions among hydrological, geomorphological, and environmental processes within aquatic and terrestrial systems. In the context of climate change, urban growth, and increased hydrologic modifications, these systems are experiencing accelerated degradation. This study employed a multi-criteria Riparian Condition Assessment (RCA) framework that combined the Riparian Condition Assessment Tool (RCAT) and a fuzzy inference system (FIS) to evaluate riparian corridor health in the Congaree River watershed, South Carolina, USA. Using 30 m LANDFIRE land-cover data, hydrologic segmentation (at 500 m reach scale), and transport infrastructure overlays, we quantified riparian vegetation deviation, land-use …

New Species Of Kronosvirus Bacteriophages That Infect Caulobacter Strain Cbr1, Tannaz Mohammadi, Austin Millwood, Maherah Shaik, Bert Ely

Faculty Publications

Caulobacter segnis strain CBR1 enhances the germination rate and total biomass of Arabidopsis plants. Since bacteriophages are usually present in the rhizosphere, we isolated three additional bacteriophages, designated TMCBR2, TMCBR3, and W2, that can replicate using CBR1 as the host strain. The genome sizes and morphologies of the new phages were similar to those of the previously isolated Kronos phage, and when we compared the nucleotide sequence of these new phage genomes, we found only minor differences among the four phage genomes. Pairwise sequence comparisons indicated that the phage genomes should be grouped into three separate species within Kronosvirus genus. …

Single State Agency Licensure Requirements For Substance Use Disorder Treatment Programs In The United States: Results Of A National Survey, Brooks Yelton Ma, Lmsw, Melissa A. Westlake, Amanda J. Abraham, Colleen M. Grogan, Olivia Hinds, Christina M. Andrews

Faculty Publications

Background

Substance use disorder (SUD) remains a critical public health crisis in the United States, with high prevalence and overdose mortality rates. Despite the availability of effective treatments, including medications that significantly reduce overdose risk, fewer than 20% of Americans with active SUD receive treatment annually. Single State Agencies (SSAs), which oversee federal funding and regulate SUD treatment programs, hold significant authority to impose licensure and reporting requirements intended to promote treatment quality.

Methods

This study presents findings from a national survey of SSAs across 50 states and the District of Columbia (94% response rate) conducted between 2020 and 2021, …

Heterogeneity Of Treatment Effects In Transcranial Direct Current Stimulation For Knee Osteoarthritis Pain And Symptoms, Chiyoung Lee, Xiaoxiao Sun, Juyoung Park, Chen X. Chen, Christine Pellegrini Ph.D., Nan-Kuei Chen, David O. Garcia, Heewon Kim, C. Kent Kwoh, Hyochol Ahn

Faculty Publications

Introduction: Although heterogeneity of treatment effects (HTEs) is commonly observed in clinical trials, it has received little attention in studies on transcranial direct current stimulation (tDCS).

Objectives: This study identified the presence of HTE in tDCS treatment among participants with symptomatic knee osteoarthritis (KOA) and explored participant characteristics associated with this heterogeneity.

Methods: This secondary analysis of a randomized clinical trial included 120 participants with symptomatic KOA who received 15 daily sessions of home-based 2-mA active or sham tDCS over 3 weeks. We used a multitrajectory analysis to identify distinct subgroups based on the longitudinal trajectories of KOA pain and …

Heterogeneity Of Treatment Effects In Transcranial Direct Current Stimulation For Knee Osteoarthritis Pain And Symptoms, Chiyoung Lee, Xiaoxiao Sun, Juyoung Park, Chen X. Chen, Christine Pellegrini, Nan-Kuei Chen, David O. Garcia, Haewon Kim, C. Kent Kwoh, Hyochoi Ahn

Faculty Publications

Introduction: Although heterogeneity of treatment effects (HTEs) is commonly observed in clinical trials, it has received little attention in studies on transcranial direct current stimulation (tDCS).

Objectives: This study identified the presence of HTE in tDCS treatment among participants with symptomatic knee osteoarthritis (KOA) and explored participant characteristics associated with this heterogeneity.

Methods: This secondary analysis of a randomized clinical trial included 120 participants with symptomatic KOA who received 15 daily sessions of home-based 2-mA active or sham tDCS over 3 weeks. We used a multitrajectory analysis to identify distinct subgroups based on the longitudinal trajectories of KOA pain and …

The Influence Of Mentoring On Educational Attitudes, Beliefs, And Behaviors (Eabbs): A Scoping Review, Amanda L. Davis, Jennifer Koide, Savannah B. Simpson, Samuel Mcquillin, Michael D. Lyons

Faculty Publications

Youth mentoring is a popular means for preventing negative psychosocial outcomes (e.g., high-risk behaviors, school dropout) and promoting positive ones (e.g., matriculation, goal setting). Mentors matched with youth through formal programs, such as Big Brothers Big Sisters, are uniquely positioned to promote the development of the mentee’s positive educational attitudes, beliefs, and behaviors (EABBs; e.g., academic engagement, grit, growth mindset). While school staff, such as school psychologists, are often unable to directly serve all students in need of support due to lack of time or large caseloads, youth mentoring may be a means to target EABB development. However, a critical …

Private Coverage, Public Risk: The Role Of Cyber Insurance In National Security Governance, Deborah L. Johnson

Faculty Publications

This Article explores the growing yet underexamined role of the commercial cyber insurance market in shaping the United States' approach to cybersecurity readiness. It argues that, as cyber threats against U.S. critical infrastructure and essential services increase, commercial cyber insurance has quietly come to function as a de facto governance tool in national cybersecurity. In hospitals, water and energy systems, and other public-facing sectors, policy language, underwriting questionnaires, and post-breach claims practices help define what counts as "reasonable" security, influence how organizations plan for and respond to incidents, and affect the pace and scope of recovery after an attack. Yet …

Roadmap On Artificial Intelligence-Augmented Additive Manufacturing, Ali Zolfagharian, Liuchao Jin, Qi Ge, Wei-Hsin Liao, Andrés Díaz Lantada, Francisco Franco Martínez, Tianyu Zhang, Tao Liu, Charlie C.L. Wang, Mohammad Hossein Mosallanejad, Reza Ghanavati, Abdollah Saboori, Alejandro De Blas De Miguel, William Solórzano-Requejo, Yi Cai, Xiangyang Dong, Huangyi Qu, Najmeh Samadiani, Guangyan Huang, Austin Downey, Yanzhou Fu, Lang Yuan

Faculty Publications

Artificial intelligence-augmented additive manufacturing (AI2AM) represents a transformative frontier in digital fabrication, where artificial intelligence (AI) is embedded not as a peripheral tool, but as a central framework driving intelligent, adaptive, and autonomous additive manufacturing (AM) systems. The objective of this Roadmap is to present a comprehensive vision of the state-of-the-art developments in AI2AM while charting the future trajectory of this rapidly emerging field. As AM applications continue to expand across diverse sectors, conventional design and control strategies face growing limitations in scalability, quality assurance, and material complexity. AI uses tools like computer vision, generative design, and large language models …

Wildfires, Smoke Pollution, And Household Purchasing Behaviors, Tamara Sheldon, Crystal Zhan

Faculty Publications

In this paper, we investigate households’ behavioral responses to wildfires in California to understand their mitigation and adaptation strategies. We combine daily household-level consumer purchase data from the NielsenIQ Consumer Panel with detailed wildfire incident and smoke exposure data from various sources. Our analysis reveals that wildfires reduce retail trips and overall spending, both in-store and online, likely due to evacuations. However, wildfire-driven smoke increases purchases of essential goods, indicating adaptive behavior. More experienced households tend to respond more cautiously, and we observe heterogeneity in responses based on income, age, and pre-existing health conditions. These findings highlight the complexity and …

Radiation Protection Factor Research: The Keystone For Conventional-Nuclear Integration (Cni), Andrew W. Decker

Faculty Publications

This article briefly describes Defense Threat Reduction Agency (DTRA) vehicle Radiation Protection Factor (RPF) research and explains its critical role in enabling future Operations in a Nuclear Environment (ONE) and Conventional-Nuclear Integration (CNI) on behalf of the US Department of War (DoW).1 As such, the background and practical utility of RPF values is discussed, as well as the justification for renewed Army and DoW investment into RPF research to enhance Joint military planning, survivability, and lethality on tomorrow’s nuclear battlefields. Advances in DTRA RPF research directly strengthen US strategic and extended deterrence efforts and support all Agencies and Departments responsible …

Factors Associated With Lapses In Care Among People Living With Hiv In South Carolina, Xueying Yang Ph.D., Fanghui Shi, Shujie Chen, Gavi Samuel, Bankole Olatosi Ph.D., Sharon Weissman, Xiaoming Li Ph.D., Jiajia Zhang Ph.D.

Faculty Publications

Utilizing statewide electronic health records (EHR) data, this study aims to assess the factors determining the occurrence of lapses in HIV care among people with HIV (PWH) in South Carolina (SC). All adult (≥ 18 years old) PWH who were diagnosed with HIV between 2006 and 2018 with at least two HIV care encounters and at least 1-year follow-up record were included in the analysis. The outcome, a lapse in care, was defined as a repeated measure of HIV care encounter that occurs over a year following the previous visit. Generalized Estimation Equation models were employed. The study cohort had …