Digital Commons Network^™

A Survey Of South Carolina Pharmacists' Readiness To Prescribe Human Immunodeficiency Virus Pre-Exposure Prophylaxis, Charles M. Burns, Kyle Endres, Caroline Derrick, Alexandra Cooper, Patricia Fabel, Nwora Lance Okeke, Divya Ahuja, Amy Corneli, Mehri S. Mckellar

Faculty Publications

Introduction: Human immunodeficiency virus (HIV) pre-exposure prophylaxis (PrEP) is largely underutilized in the Southern United States. Given their community presence, pharmacists are well positioned to provide PrEP within rural, Southern regions. However, pharmacists' readiness to prescribe PrEP in these communities remains unknown. Objective: To determine the perceived feasibility and acceptability of prescribing PrEP by pharmacists in South Carolina (SC). Methods: We distributed a 43-question online descriptive survey through the University of South Carolina Kennedy Pharmacy Innovation Center's listserv of licensed SC pharmacists. We assessed pharmacists' comfort, knowledge, and readiness to provide PrEP. Results: A total of 150 pharmacists responded to …

Retraction, N. Kinoshita, M. Paul, Y. Kashiv, P. Collon, C. M. Deibel, B. Digiovine, J. P. Greene, C. L. Jiang, S. T. Marley, R. C. Pardo, K. E. Rehm, D. Robertson, R. Scott, C. Schmitt, X. D. Tang, R. Vondrasek, A. Yokoyama

Faculty Publications

No abstract provided.

Slow-Goverance In Smart Cities: An Empirical Study Of Smart Intersection Implementation In Four U. S. College Towns, Brett Frischmann, Madelyn Rose Sanfilippo

Faculty Publications

Cities cannot adopt supposedly smart technological systems and protect human rights without developing appropriate data governance, because technologies are not value-neutral. This paper proposes a deliberative, slow-governance approach to smart tech in cities. Inspired by the Governing Knowledge Commons (GKC) framework and past case studies, we empirically analyse the adoption of smart intersection technologies in four US college towns to evaluate and extend knowledge commons governance approaches to address human rights concerns. Our proposal consists of a set of questions that should guide community decision-making, extending the GKC framework via an incorporation of human-rights impact assessments and a consideration of …

Meeting Patients Where They Are: A Nurse-Driven Quality Improvement Project To Provide Influenza Vaccinations In The Emergency Department, Stacie Hunsaker, Larry Garrett, Katreena Merrill, Rachelle Rhodes

Faculty Publications

Introduction: Influenza is highly contagious, vaccine-preventable, and may result in significant morbidity and mortality. While vaccination is the primary protection against influenza, vaccination rates remain low. Traditionally, primary care clinics, retail pharmacies, and public health departments offer influenza vaccines. However, offering influenza vaccines in new settings may increase their availability to the public and increase community uptake. This project aimed to add emergency departments as a new influenza vaccine location to increase the number of vaccines distributed during the 2020 to 2021 influenza season.

Methods: Adult patients discharged from 24 emergency departments were included in this pre- post-intervention project. A …

Tcf21 Marks Visceral Adipose Mesenchymal Progenitors And Functions As A Rate-Limiting Factor During Visceral Adipose Tissue Development, Qianglin Liu, Chaoyang Li, Buhao Deng, Peidong Gao, Leshan Wang, Yuxia Li, Mohammad Shiri, Fozi Alkaifi, Junxing Zhao, Jacqueline M. Stephens, Constantine A. Simintiras, Joseph Francis, Jiangwen Sun, Xing Fu

Faculty Publications

Distinct locations of different white adipose depots suggest anatomy-specific developmental regulation, a relatively understudied concept. Here, we report a population of Tcf21 lineage cells (Tcf21 LCs) present exclusively in visceral adipose tissue (VAT) that dynamically contributes to VAT development and expansion. During development, the Tcf21 lineage gives rise to adipocytes. In adult mice, Tcf21 LCs transform into a fibrotic or quiescent state. Multiomics analyses show consistent gene expression and chromatin accessibility changes in Tcf21 LC, based on which we constructed a gene-regulatory network governing Tcf21 LC activities. Furthermore, single-cell RNA sequencing (scRNA-seq) identifies the heterogeneity of Tcf21 LCs. Loss of …

Capturing Children Food Exposure Using Wearable Cameras And Deep Learning, Shady Elbassuoni, Hala Ghattas Ph.D., Jalila El Ati, Yorgo Zoughby, Aline Semaan, Christelle Akl, Tarek Trabelsi, Reem Talhouk, Houda Ben Gharbia, Zoulfikar Shmayssani, Aya Mourad

Faculty Publications

Children’s dietary habits are influenced by complex factors within their home, school and neighborhood environments. Identifying such influencers and assessing their effects is traditionally based on self-reported data which can be prone to recall bias. We developed a culturally acceptable machine-learning-based data-collection system to objectively capture school-children’s exposure to food (including food items, food advertisements, and food outlets) in two urban Arab centers: Greater Beirut, in Lebanon, and Greater Tunis, in Tunisia. Our machine-learning-based system consists of 1) a wearable camera that captures continuous footage of children’s environment during a typical school day, 2) a machine learning model that automatically …

Toward A Simulation Model Complexity Measure, J. Scott Thompson, Douglas D. Hodson, Michael R. Grimaila, Nicholas Hanlon, Richard Dill

Faculty Publications

Is it possible to develop a meaningful measure for the complexity of a simulation model? Algorithmic information theory provides concepts that have been applied in other areas of research for the practical measurement of object complexity. This article offers an overview of the complexity from a variety of perspectives and provides a body of knowledge with respect to the complexity of simulation models. The key terms model detail, resolution, and scope are defined. An important concept from algorithmic information theory, Kolmogorov complexity, and an application of this concept, normalized compression distance, are used to indicate the possibility of measuring changes …

Control Education For Societal-Scale Challenges: A Community Roadmap, John Anthony Rossiter, Christos G. Cassandras, João Hespanha, Sebastian Dormido, Luis De La Torre, Gireeja Ranade, Antonio Visioli, John Hedengren, Richard M. Murray, Panos Antsaklis, Francoise Lamnabhi-Lagarrigue, Thomas Parisini

Faculty Publications

This article focuses on extending, disseminating and interpreting the findings of an IEEE Control Systems Society working group looking at the role of control theory and engineering in solving some of the many current and future societal challenges. The findings are interpreted in a manner designed to give focus and direction to both future education and research work in the general control theory and engineering arena, interpreted in the broadest sense. The paper is intended to promote discussion in the community and also provide a useful starting point for colleagues wishing to re-imagine the design and delivery of control-related topics …

A Diversity, Equity, And Inclusion Audit Of The American Families Of Faith Project: Exploring Lifespan Spiritual Development In Religiously And Racially Diverse Families, David C. Dollahite, Justin J. Hendricks, Loren D. Marks

Faculty Publications

Social science and religious studies scholars should endeavor to broaden theories, methods, and samples to be more inclusive. Therefore, we have conducted an “equity audit” of the American Families of Faith (AFF) project. We evaluated the diversity, equity, and inclusion of the AFF project’s (a) research team, (b) products, and (c) samples. We then discuss the reasoning behind the decisions that resulted in the existing strengths and limitations of the project, the fruits of this and previous evaluations (including a presentation of some narrative accounts from parents and youths across several religious-ethnic communities across the US), opportunities for growth, and …

Delineating The Effects Of Molecular And Colloidal Interactions Of Dissolved Organic Matter On Titania Photocatalysis, Mostafa Maghsoodi, Céline Jacquin, Benoit Teychené, Geoffroy Lesage, Samuel D. Snow

Faculty Publications

In the face of significant challenges to practical applications of photocatalysis for water treatment, recent reports revealed a potential route to overcome a problem posed by dissolved organic matter (DOM). These studies showed that inhibition of photocatalytic processes by DOM is driven largely by competition for active surface sites on TiO2 or other catalysts, and controlling the type of DOM present in solution could significantly mitigate DOM fouling. Whether or not control of solution parameters could achieve the same preventative action is not known. Here, a series of DOM isolates, including humic acid (HA) and transphilic (TPI), hydrophobic (HPO), or …

Student Preferences For Active Learning And Their Beliefs, Experiences, And Knowledge, Tammy Shilling, Jerome Thayer, Anneris Coria-Navia, Heather Ferguson

Faculty Publications

Active teaching methods are believed to facilitate higher-order thinking skills and prepare allied health students for independent clinical decision-making. This quantitative, correlational study aimed to explain the relationships between student preferences for active over traditional methods and their beliefs, the frequency and positiveness of their experiences, and the extent of knowledge they have received regarding active and traditional teaching methods. Two hundred and thirty students completed a 53-item online survey. Students were enrolled in a Doctor of Physical Therapy, Masters in Speech-language Pathology, or Bachelor of Science Nursing program in one of seventeen participating institutions across a ten-state Midwest region. …

Synthetic Strategies Of Supported Pd-Based Bimetallic Catalysts For Selective Semi-Hydrogenation Of Acetylene: A Review And Perspectives, Xinxiang Cao, Ben W.-L. Jang, Jiaxue Hu, Lei Wang

Faculty Publications

Selective semi-hydrogenation of acetylene is an extremely important reaction from both industrial and theoretical perspectives. Palladium, due to its unique chemical and physical properties, is the most active and currently irreplaceable metal for this reaction in industry, but the poor catalytic selectivity towards ethylene is also its inherent shortcoming. Introducing a secondary metal to tune a geometric and electronic structures of Pd nanoparticles and to create a synergistic effect is the most widely used strategy to effectively improve the overall catalytic performance of Pd-based catalysts. Thus, various supported Pd-based bimetallic catalysts for selective semi-hydrogenation of acetylene have been exploited in …

Practices And Perceptions Of Family-Centered Care: A Cross-Sectional Survey Of Secondary School Athletic Trainers, Zachary K. Winkelmann, Nancy A. Uriegas, James M. Mensch, Conner E. Montgomery, Toni M. Torres-Mcgehee

Faculty Publications

Family-centered care (FCC) includes collaboration between families and healthcare providers, the creation of flexible policies, and the family taking an active role in the delivery of care. Secondary school athletic trainers provide care for underage patients in school-based health systems, making them responsible for maintaining communication with parents, guardians, and/or caregivers. This cross-sectional survey investigated the extent to which athletic trainers (n = 205) include aspects of FCC in their daily secondary school clinical practice (current practices = CP) and whether they believe that aspect of care is necessary for FCC to be provided in athletic training (perceived necessary = …

Perspectives On Lifespan Religious And Spiritual Development From Scholars Across The Lifespan, Megan Gale, Justin J. Hendricks, David C. Dollahite, Loren D. Marks

Faculty Publications

The purpose of the article is to share our perspectives on the key influences of lifespan religious and spiritual development as scholars from across the lifespan (i.e., the four authors are from different generations, including Baby Boomers, Generation X, Millennials, and Gen Z). Our perspectives are heavily influenced by our combined 60+ years of research experience in examining the connections between religion and family life. Our discussion is organized around Bronfenbrenner’s bioecological framework and the process-person-context-time model. Within this framework, the key factors we discuss that influence religious/spiritual development include (a) process (i.e., person-religion mismatch and family processes), (b) person …

Altogether Now! Early Introduction Of Case-Based Learning For Success In Clinical Chemistry, Cristy E. Moss

Faculty Publications

•Differentiate between active & passive learning. •Identify ways early integration of case-based learning is beneficial for the medical laboratory student. •Summarize current methods for Integration of case-based activities into routine lecture / discussion sessions with students.

Are Denisons In A Political Bubble, Miles Williams, Paul Djupe

Faculty Publications

No abstract provided.

Affective Depression Mediates Ptsd To Suicide In A Sample Of Treatment-Seeking First Responders, James Whitworth, Jeanine Galusha, Jose Carbajal, Warren Ponder, Donna Schuman

Faculty Publications

Objective: The aim of this study was to examine the associations of comorbid

posttraumatic stress disorder (PTSD), affective or somatic depression, and

suicide among first responders (FRs). Method: We used baseline data from

FRs (N = 232) who sought services at a nonprofit mental health agency specializing

in treating trauma exposed FRs. We conducted two PROCESS simple

mediation models with PTSD as the predictor, affective depression and somatic

depression as the mediators, and suicidality as the dependent variable.

Results: Affective depression significantly mediated the relationship between

PTSD and suicidality, whereas somatic depression did not. The direct effect …

Field Applications Of Zein As A Precise Nanoscale Delivery System For Methoxyfenozide, C. A.R. Bonser, C. Tamez, J. C. White, C. E. Astete, C. M. Sabliov, J. A. Davis

Faculty Publications

When insecticides are applied in the environment, much of the product does not reach the target pest. Biopolymeric nanoparticles as nanocarriers have the potential to improve insecticide efficacy by improving absorption, coverage, and permeability while protecting the insecticide active ingredient from abiotic conditions and extending efficacy through controlled release. We conducted a series of experiments using a biopolymeric nanoparticle synthesized from zein, a biodegradable maize protein, to compare efficacy of a nanodelivered hydrophobic insect growth regulator (methoxyfenozide) against a commercial formulation. Positively charged zein nanoparticles (empty and loaded with methoxyfenozide) were compared to the formulated product, Intrepid 2F, as a …

Impact Of Nonconventional Selection By Insecticides On Susceptibility Of The Southern House Mosquito, Culex Quinquefasciatus, Vivek Pokhrel, James A. Ottea

Faculty Publications

Mosquitoes are an important target of pest control as they vector pathogens that are associated with many debilitating human diseases. Given that mosquitoes have been selected with insecticides for over 100 years, much is known about the development of insecticide resistance associated with targeted application against populations of these insects. However, off-target selection by applications of insecticides in agricultural and residential sites also impacts development of insecticide resistance and is understudied. Similarly, the impact of selecting one life stage of mosquitoes on the insecticide susceptibility of different life stages is largely unknown. Here, we show that susceptibility to chlorantraniliprole, which …

Recent Advances And Challenges In Implementing Ipm Programmes In The Entomological Context Of Indian Agriculture, Ruchika Geedi, Gadi V.P. Reddy

Faculty Publications

Integrated pest management (IPM) programmes are based on using multiple methods to maintain nuisance insects below tolerant levels in crop fields. Recent advances in IPM in developed countries have incorporated biological pesticides, microbial products, semiochemicals, and beneficial insects, but few of such programmes have been successfully implemented in developing countries, such as India. Semiochemicals play critical roles as signals in various interspecific and intraspecific interactions between insects and plants, and among interacting insects, plants, and microbes. In India IPM programmes have included mechanical, chemical, cultural, and biological management strategies. However, among these methods, biological management has its own limitations. Indian …

A Draft Of The Genome Of The Gulf Coast Tick, Amblyomma Maculatum, Jose M.C. Ribeiro, Natalia J. Bayona-Vásquez, Khemraj Budachetri, Deepak Kumar, Julia Catherine Frederick, Faizan Tahir, Brant C. Faircloth, Travis C. Glenn, Shahid Karim

Faculty Publications

The Gulf Coast tick, Amblyomma maculatum, inhabits the Southeastern states of the USA bordering the Gulf of Mexico, Mexico, and other Central and South American countries. More recently, its U.S. range has extended West to Arizona and Northeast to New York state and Connecticut. It is a vector of Rickettsia parkeri and Hepatozoon americanum. This tick species has become a model to study tick/Rickettsia interactions. To increase our knowledge of the basic biology of A. maculatum we report here a draft genome of this tick and an extensive functional classification of its proteome. The DNA from a single …

Using Automated Speech Processing For Repeated Measurements In A Clinical Setting Of The Behavioral Variability In The Stroop Task, Terje B. Holmlund, Alex S. Cohen, Jian Cheng, Peter W. Foltz, Jared Bernstein, Elizabeth Rosenfeld, Bruno Laeng, Brita Elvevåg

Faculty Publications

The Stroop interference task is indispensable to current neuropsychological practice. Despite this, it is limited in its potential for repeated administration, its sensitivity and its demands on professionals and their clients. We evaluated a digital Stroop deployed using a smart device. Spoken responses were timed using automated speech recognition. Participants included adult nonpatients (N = 113; k = 5 sessions over 5 days) and patients with psychiatric diagnoses (N = 85; k = 3–4 sessions per week over 4 weeks). Traditional interference (difference in response time between color incongruent words vs. color neutral words; M = 0.121 s) and facilitation …

Factors Influencing Consumers’ Willingness-To-Try Seafood Byproducts, Silvia Murillo, Ryan Ardoin, Witoon Prinyawiwatkul

Faculty Publications

With increasing global demand for seafood, seafood byproducts (SB) utilization can contribute to a more sustainable food supply chain through waste-to-value food product development. However, consumer perceptions of SB (e.g., fish skin and bones) are underexplored. Therefore, this study aims to evaluate some factors influencing consumers’ willingness-to-try seafood byproducts. An online survey was conducted in the USA regarding intervention of SB informational cues with N = 904 adult seafood consumers internationally. The proportion of consumers willing to try SB increased significantly (McNemar’s test, α = 0.05) from 47% to 68% after SB safety and health claims had been presented in …

Can Biodiversity Of Preexisting And Created Salt Marshes Match Across Scales? An Assessment From Microbes To Predators, Friedrich W. Keppeler, James R. Junker, Margaret J. Shaw, Scott B. Alford, Annette S. Engel, Linda M. Hooper-Bùi, Olaf P. Jensen, Katelyn Lamb, Paola C. López-Duarte, Charles W. Martin, Ashley M. Mcdonald, Jill A. Olin, Audrey T. Paterson, Michael J. Polito, Nancy N. Rabalais, Brian J. Roberts, Ryann E. Rossi, Erick M. Swenson

Faculty Publications

Coastal wetlands are rapidly disappearing worldwide due to a variety of processes, including climate change and flood control. The rate of loss in the Mississippi River Delta is among the highest in the world and billions of dollars have been allocated to build and restore coastal wetlands. A key question guiding assessment is whether created coastal salt marshes have similar biodiversity to preexisting, reference marshes. However, the numerous biodiversity metrics used to make these determinations are typically scale dependent and often conflicting. Here, we applied ecological theory to compare the diversity of different assemblages (surface and below-surface soil microbes, plants, …

Unhealthy Herds And The Predator–Spreader: Understanding When Predation Increases Disease Incidence And Prevalence, Robert L. Richards, Bret D. Elderd, Meghan A. Duffy

Faculty Publications

Disease ecologists now recognize the limitation behind examining host–parasite interactions in isolation: community members—especially predators—dramatically affect host–parasite dynamics. Although the initial paradigm was that predation should reduce disease in prey populations (“healthy herds hypothesis”), researchers have realized that predators sometimes increase disease in their prey. These “predator–spreaders” are now recognized as critical to disease dynamics, but empirical research on the topic remains fragmented. In a narrow sense, a “predator–spreader” would be defined as a predator that mechanically spreads parasites via feeding. However, predators affect their prey and, subsequently, disease transmission in many other ways such as altering prey population structure, …

Using The Exploration, Preparation, Implementation, And Sustainment (Epis) Framework To Advance The Science And Practice Of Healthy Food Retail, Bailey Houghtaling, Sarah Misyak, Elena Serrano, Rachael D. Dombrowski, Denise Holston, Chelsea R. Singleton, Samantha M. Harden

Faculty Publications

Although healthy food retail strategies are widely used, there appears to be a limited understanding of the processes and determinants for successful adoption, implementation, and sustainment. To fill this gap, we recommend the Exploration, Preparation, Implementation, and Sustainment (EPIS) framework to be used to advance the science and practice of healthy food retail. In this perspective, we: (1) introduce EPIS and describe why it was chosen as a recommended implementation science framework for healthy food retail, (2) highlight healthy food retail evidence supporting EPIS, and (3) discuss research and practice needs moving forward.

The Interaction Of Rurality And Rare Cancers For Travel Time To Cancer Care, Tracy Onega, Jennifer Alford-Teaster, Chris Leggett, Andrew Loehrer, Julie E. Weiss, Erika L. Moen, Catherine C. Pollack, Fahui Wang

Faculty Publications

Purpose: Geographic access to cancer care is known to significantly impact utilization and outcomes. Longer travel times have negative impacts for patients requiring highly specialized care, such as for rare cancers, and for those in rural areas. Scant population-based research informs geographic access to care for rare cancers and whether rurality impacts that access. Methods: Using Medicare data (2014-2015), we identified prevalent cancers and cancer-directed surgeries, chemotherapy, and radiation. We classified cancers as rare (incidence <6/100,000/year) or common (incidence ≥6/100,000/year) using previously published thresholds and categorized rurality from ZIP code of beneficiary residence. We estimated travel time between beneficiaries and providers for each service based on ZIP code. Descriptive statistics summarized travel time by rare versus common cancers, service type, and rurality. Findings: We included 1,169,761 Medicare beneficiaries (21.9% in nonmetropolitan areas), 87,399; 7.5% had rare cancers, with 9,133,003 cancer-directed services. Travel times for cancer services ranged from approximately 29 minutes (25th percentile) to 68 minutes (75th percentile). Travel times were similar for rare and common cancers overall (median: 45 vs 43 minutes) but differed by service type; 13.4% of surgeries were >2 hours away for rare cancers, compared to 8.3% for common cancers. Increasing rurality disproportionately increased travel time to surgical care for rare compared to …

Surface Plasmon Resonance (Spr) Sensor For Cancer Biomarker Detection, Sreyashi Das, Ram Devireddy, Manas Ranjan Gartia

Faculty Publications

A biomarker is a physiological observable marker that acts as a stand-in and, in the best-case scenario, forecasts a clinically significant outcome. Diagnostic biomarkers are more convenient and cost-effective than directly measuring the ultimate clinical outcome. Cancer is among the most prominent global health problems and a major cause of morbidity and death globally. Therefore, cancer biomarker assays that are trustworthy, consistent, precise, and verified are desperately needed. Biomarker-based tumor detection holds a lot of promise for improving disease knowledge at the molecular scale and early detection and surveillance. In contrast to conventional approaches, surface plasmon resonance (SPR) allows for …

On The Effect Of Environmental Temperature On Fracture Fatigue Entropy, Mohammad A. Amooie, M. M. Khonsari

Faculty Publications

Fracture behavior of carbon steel 1018 operating in low-temperature environments is investigated. Specifically, fully-reversed bending experimental tests are performed to examine the efficacy of applying the concept of Fracture Fatigue Entropy (FFE) for predicting fatigue life at different environmental temperatures. A large cooling chamber was constructed that houses the entire bending test rig and maintains the environmental temperature at the desired value down to −10 °C. It is shown that under conditions tested, fatigue life improves at lower operating temperatures. Results also reveal that FFE remains nearly constant and can be used for reliable prediction of fatigue life. Illustrative examples …

Policy Comparison Of Lead Hunting Ammunition Bans And Voluntary Nonlead Programs For California Condors, Robin M. Rotman, John H. Schulz, Samantha Totoni, Sonja A. Wilhelm Stanis, Christine Jie Li, Mark Morgan, Damon M. Hall, Elisabeth B. Webb

Faculty Publications

The endangered California condor (Gymnogyps californianus) is negatively affected by lead poisoning from spent lead‐based hunting ammunition. Because lead poisoning is the primary mortality factor affecting condors, the California Fish and Game Commission banned lead hunting ammunition during 2008 in the southern California condor range followed by a statewide ban implemented in 2019. In contrast, the Arizona Game and Fish Department instituted an outreach and awareness program encouraging voluntary use of nonlead hunting ammunition in the northern portion of the state during 2005 and a similar program was launched in Utah during 2012. The juxtaposition of policy tools provided a …