Digital Commons Network^™

Developing An Ethical Framework-Guided Instrument For Assessing Bias In Ehr-Based Big Data Studies: A Research Protocol, Shan Qiao Ph.D., George Khushf, Xiaoming Li, Jiajia Zhang Ph.D., Bankole Olatosi Ph.D.

Faculty Publications

Introduction The emergence of Big Data health research has exponentially advanced the fields of medicine and public health but has also faced many ethical challenges. One of most worrying but still under-researched aspects of the ethical issues is the risk of potential biases in data sets (eg, electronic health records (EHR) data) as well as in the data curation and acquisition cycles. This study aims to develop, refine and pilot test an ethical framework-guided instrument for assessing bias in Big Data research using EHR data sets.

Methods and analysis Ethical analysis and instrument development (ie, the EHR bias assessment guideline) …

Cdk8 And Cdk19: Positive Regulators Of Signal-Induced Transcription And Negative Regulators Of Mediator Complex Proteins, Mengqian Chen, Jing Li, Li Zhang, Lili Wang, Chen Cheng, Hao Ji, Serena Altilia, Xiaokai Ding, Guoshuai Cai, Diego Altomare, Michael Shtutman, Stephanie D. Byrum, Samuel G. Mackintosh, Alexey Feoktistov, Nataliya Soshnikova, Vladislav A. Mogila, Victor Tatarskiy, Maksim Erokhin, Darya Chetverina, Angga Prawira, Yi Ni, Stephan Urban, Campbell Mcinnes, Eugenia Broude, Igor Roninson

Faculty Publications

We have conducted a detailed transcriptomic, proteomic and phosphoproteomic analysis of CDK8 and its paralog CDK19, alternative enzymatic components of the kinase module associated with transcriptional Mediator complex and implicated in development and diseases. This analysis was performed using genetic modifications of CDK8 and CDK19, selective CDK8/19 small molecule kinase inhibitors and a potent CDK8/19 PROTAC degrader. CDK8/19 inhibition in cells exposed to serum or to agonists of NFκB or protein kinase C (PKC) reduced the induction of signal-responsive genes, indicating a pleiotropic role of Mediator kinases in signal-induced transcriptional reprogramming. CDK8/19 inhibition under basal conditions initially downregulated a small …

Changes In Medicaid Fee-For-Service Benefit Design For Substance Use Disorder Treatment During The Opioid Crisis, 2014 To 2021, Angela Shoulders, Christina Andrews, Melissa A. Westlake, Amanda J. Abraham, Colleen M. Grogan

Faculty Publications

Importance: Medicaid is the largest payer of substance use disorder treatment in the US and plays a key role in responding to the opioid epidemic. However, as recently as 2017, many state Medicaid programs still did not cover the full continuum of clinically recommended care. Objective: To determine whether state Medicaid fee-for-service (FFS) programs have expanded coverage and loosened restrictions on access to substance use disorder treatment in recent years. Design, Setting, and Participants: In 2014, 2017, and 2021, a survey on coverage for substance use disorder treatment was conducted among state Medicaid programs and the District of Columbia with …

Best Practices For Edd Comprehensive Exams And Capstone Projects: Students' Attitudes And Perspectives Of Outcomes In An Online Program, Masha Krsmanovic, Holly A. Foster

Faculty Publications

This research was guided by a problem of practice experienced by an EdD program, which transitioned to a fully online modality during the pandemic and rapidly grew in enrollment. The problem evaluated was ensuring the redesigned program milestones – capstone and comprehensive exam – are feasible given the size of the program. The current study utilized descriptive research design to provide a comprehensive description of educational phenomena. The study was conducted at a large, public research university in the South. A total of 316 students enrolled in the program and were invited to complete the survey, of which 131 responses …

The Association Between Covid-19 Preventive Behaviors And Mental Health Conditions, Elizabeth Wachira, Bhakti Chavan, Carolyn Nganga-Good, Caroline Kingori

Faculty Publications

Our findings highlight that individuals with mental health conditions reported more psychological distress. Specifically, feeling depressed, anxious, lonely, and hopeless were triggered and exacerbated as a result of the pandemic and may have long-term effects on general well-being and productivity. Therefore, our findings have important implications on the need to include mental health promotion as part of pandemic response efforts. This includes developing policies and allocating funding so as to ensure sustainable mental health interventions and support, public and provider education on the importance of screening for mental health issues.

Longitudinal Assessment Of Cognitive Function In The Appswe/Ps1de9 Mouse Model Of Alzheimer's-Related Beta-Amyloidosis, Paul L. Soto, Michael E. Young, Giuliana M. Dimarco, Brianna George, Tatiana Melnikova, Alena V. Savonenko, Breanna N. Harris

Faculty Publications

Preclinical models of Alzheimer's disease (AD)-related cognitive decline can be useful for developing therapeutics. The current study longitudinally assessed short-term memory, using a delayed matching-to-position (DMTP) task, and attention, using a 3-choice serial reaction time (3CSRT) task, from approximately 18 weeks of age through death or 72 weeks of age in APPswe/PS1dE9 mice, a widely used mouse model of AD-related amyloidosis. Both transgenic (Tg) and non-Tg mice exhibited improvements in DMTP accuracy over time. Breaks in testing reduced DMTP accuracy but accuracy values quickly recovered in both Tg and non-Tg mice. Both Tg and non-Tg mice exhibited high accuracy in …

Quality Of Farmed Shrimp (Penaeus Monodon, Fabricius, 1798 And Macrobrachium Rosenbergii, Deman, 1879) As Affected By Melanosis Inhibiting Compounds, M. Khan, J. A. Lively

Faculty Publications

A problem associated with shrimp is blackspot or melanosis and to prevent blackspot, sulfites have been used for years but come with additional health risks. Newer 4-hexylresorcinol formulations exist that allow sulfite-free shrimp, but effects on the quality of Penaeus monodon Fabricius, 1798, and Macrobrachium rosenbergii, de Man, 1879, beyond melanosis prevention are unknown. Adverse effects on the quality of the shrimp from melanosis prevention treatments would negatively offset the benefits of a sulfite-free product. In order to determine if prevention compounds (sulfite powder or 4-hexylresorcinol based compounds, Everfresh® and Xyrex® Prawnfresh™) affect quality, proximate composition and total plate count …

Impact Of Reactive Oxygen Species Scavenging On The Intermediate Production Of Anthracene And Anthraquinone In Fresh Versus Saltwater Environments, Scott J. St. Romain, Laura M. Basirico, Yong Ha Kim, Emily Vebrosky Nolan, Wei Xu, Kevin L. Armbrust

Faculty Publications

While salinity can alter the photodegradation of hydrophobic organic compounds (HOCs), the cause of their altered kinetics in seawater is not well understood. Because HOC intermediate photoproducts are often more toxic than their parent compounds, characterizing the generation of intermediates in saline environments is needed to accurately predict their health effects. The present study investigated the influence of salinity on the generation of anthraquinone through the photolysis of anthracene and the generation of anthrone and 1-hydroxyanthraquinone from the photolysis of anthraquinone as well as their reactivities with hydroxyl radicals. This was conducted by measuring the photolysis rates of anthracene and …

Chemical Characterization And Impact Of Nipple Fruit (Solanum Mammosum) On The Characteristics Of Lactobacillus Acidophilus La K, Ricardo S. Aleman, Dany Avila, Allan Avila, Jack N. Losso, David Picha, Zhimin Xu, Kayanush Aryana

Faculty Publications

Nipple fruit (Solanum mammosum) has been considered to have great pharmaceutical potential because of its high amounts of solamargine and solasonine. This study aimed to examine the effect of nipple fruit at different concentrations (0.5%, 1%, and 2% (w/v)) on the viability, acid, bile, lysozyme, and gastric juice tolerance, and protease activity of Lactobacillus acidophilus LA K. The viability was studied in MRS broth. Acid tolerance was determined by adjusting the pH to 2, whereas bile tolerance was examined with oxgall 0.3% (w/v) in MRS broth. Lysozyme resistance was investigated in an electrolyte solution with lysozyme (100 mg/L), while gastric …

Unlocking The Potential Of Kinase Targets In Cancer: Insights From Canceromicsnet, An Ai-Driven Approach To Drug Response Prediction In Cancer, Manali Singha, Limeng Pu, Gopal Srivastava, Xialong Ni, Brent A. Stanfield, Ifeanyi K. Uche, Paul J.F. Rider, Konstantin G. Kousoulas, J. Ramanujam, Michal Brylinski

Faculty Publications

Deregulated protein kinases are crucial in promoting cancer cell proliferation and driving malignant cell signaling. Although these kinases are essential targets for cancer therapy due to their involvement in cell development and proliferation, only a small part of the human kinome has been targeted by drugs. A comprehensive scoring system is needed to evaluate and prioritize clinically relevant kinases. We recently developed CancerOmicsNet, an artificial intelligence model employing graph-based algorithms to predict the cancer cell response to treatment with kinase inhibitors. The performance of this approach has been evaluated in large-scale benchmarking calculations, followed by the experimental validation of selected …

Editorial Introduction: Exploring Theories And Subtleties Of The Policy Process, Geoboo Song, Melissa K. Merry, Nataliia Borozdina, Ben Galloway, Gwen Arnold, Aaron Smith-Walter, Holly L. Peterson, Creed Tumlison

Faculty Publications

No abstract provided.

Discipling The Whole Person, Scott R. Ward, David Sedlacek, Rogelio Paquini, Jasmine Fraser

Faculty Publications

No abstract provided.

Mining Chinese Consumer Minds: Motivations For Selling Unwanted Fashion Items In Online Resale Marketplaces, Zhongjie Wang, Chuanlan Liu

Faculty Publications

With the development of China’s fashion resale market, sustainable consumption patterns have gradually become popular in China. Although the prospects of China’s fashion resale market are recognized, more and more consumers are also actively participating in the circular consumption model. Consumers have multiple identities in participating in resale, and can be sellers or buyers. However, the sales intention of Chinese consumers to participate in resale as sellers is still unclear. We need to understand what value Chinese consumers are looking for in resale as sellers. The focus of this exploratory study is to understand the intention of Chinese consumers to …

The Dynamic Nature Of Wrack: An Investigation Into Wrack Movement And Impacts On Coastal Marshes Using Suas, Grayson R. Morgan, Daniel R. Morgan, Cuizhen Wang, Michael E. Hodgson, Steven R. Schill

Faculty Publications

This study investigates the use of small unoccupied aerial systems (sUAS) as a new remote sensing tool to identify and track the spatial distribution of wrack on coastal tidal marsh systems. We used sUAS to map the wrack movement in a Spartina alterniflora-dominated salt marsh monthly for one year including before and after Hurricane Isaias that brought strong winds, rain, and storm surge to the area of interest in August 2020. Flight parameters for each data collection mission were held constant including collection only during low tide. Wrack was visually identified and digitized in a GIS using every mission orthomosaic …

The Municipal Acequias Of San Fernando De Béxar: A Working Paper, José A. Rivera Ph.D

Faculty Publications

Of the seven acequia irrigation systems constructed during the height of San Antonio’s Spanish colonial period, five were built for the benefit of the Franciscan missions and their indigenous residents: San Antonio de Valero, Nuestra Señora de la Purísima Concepción de Acuña, San José y San Miguel de Aguayo, San Juan Capistrano, and San Francisco de la Espada. In addition to the five mission acequias, other diversions from the Río de San Antonio and San Pedro Creek were constructed for civilian use within the municipality of San Fernando de Béxar, founded in 1731, now San Antonio: the San Pedro Acequia …

That Ye Might Feel And See: Touch In The First Day Of Christ's Ministry, Dan L. Belnap

Faculty Publications

No abstract provided.

The Emergence Of Convergence, Shana M. Sundstrom, David G. Angeler, Jessica G. Ernakovich, Jorge H. Garcia, Joseph A. Hamm, Orville Huntington, Craig R. Allen

Faculty Publications

Science is increasingly a collaborative pursuit. Although the modern scientific enterprise owes much to individuals working at the core of their field, humanity is increasingly confronted by highly complex problems that require the integration of a variety of disciplinary and methodological expertise. In 2016, the U.S. National Science Foundation launched an initiative prioritizing support for convergence research as a means of “solving vexing research problems, in particular, complex problems focusing on societal needs.” We discuss our understanding of the objectives of convergence research and describe in detail the conditions and processes likely to generate successful convergence research. We use our …

Structural Behavior Of Reactive Powder Concrete Under Harmonic Loading, Shatha D. Mohammed, Teghreed H. Ibrahim, Ban F. Salman, Abbas A. Allawi

Faculty Publications

Industrial buildings usually are designed to sustain several types of load systems, such as dead, live, and dynamic loads (especially the harmonic load produced by rotary motors). In general, these buildings require high-strength structural elements to carry the applied loads. Moreover, Reactive Powder Concrete (RPC) has been used for this purpose because of its excellent mechanical strength and endurance. Therefore, this study provides an experimental analysis of the structural behaviors of reinforced RPC beams under harmonic loads. The experimental program consisted of testing six simply supported RPC beams with lengths of 1500 mm, widths of 150 mm, and thicknesses of …

Nanotechnology As A Foundational Tool To Combat Global Food Insecurity, Melanie Kah, Cristina Sabliov, Yi Wang, Jason C. White

Faculty Publications

With a global population racing toward 10 billion people in the next 25 years, the challenge to global food production, storage, and distribution will be immense. There are a range of technologies and strategies that could, at least in theory, be successfully applied to improve food security in a sustainable way. Nanotechnology is one such strategy that is being increasingly recognized as having great potential. Here, we present examples of how nanotechnology can be applied from farm to fork and help to improve availability, access, and utilization of food. We also discuss major challenges associated with efficient production and deployment …

The Hidden Power Of “Thank You”: Exploring Aspects, Expressions, And The Influence Of Gratitude In Religious Families, Joe M. Chelladurai, Loren D. Marks, David C. Dollahite, Heather H. Kelley, David B. Allsop

Faculty Publications

Gratitude has been extensively studied over the past two decades. Among several predictors, aspects of religiosity and spirituality have been consistent predictors of gratitude. To explore the religious motivations and processes that foster the practice of gratitude, we undertook a systematic thematic analysis using interview data from a national qualitative project of 198 highly religious families. Participants (n = 476) included mothers, fathers, and children from various socioeconomic backgrounds and from diverse religious, racial, and ethnic backgrounds in the United States of America. Semi-structured interviews were conducted in the participants’ homes. Data for this study were analyzed using a team-based …

Whose Social Capital?: Citation And Co-Citation Patterns Of A Fragmented Concept, Jimi Adams, Kate Vinita Fitch

Faculty Publications

Despite its wide use across the social sciences, social capital research has been regularly criticized as having fuzzy conceptualization, resulting in multiple (potentially conflicting) operationalizations. Our analyses employ bibliometric analytic tools to demonstrate the disconnected structure of social capital research. The resulting visualization illustrates one potential source of the confusion surrounding social capital—that there are many, potentially nonoverlapping versions of the idea rather than one unified social capital concept.

Family Experiences Of Engagement In Inclusive Childcare Programs For Toddlers, Julianna Lieb, Audra Classen, Lindsay Wright, Hollie Filce

Faculty Publications

Previous research has explored family engagement experiences and practices in childcare programs. The purpose of this study was to explore family members’ experiences related to their engagement in decision-making processes across various inclusive, toddler childcare programs. Five early educators and eight parents participated in the study. Four parents had a child with a diagnosed disability or developmental delays, were at-risk for developmental delays, and/or received speech, occupational, or physical therapy. Eligible early educators participating in the study taught toddlers (18 to 30 months) in a private, faith-based, or university childcare program. A semi-structured interview style was used to collect family …

Gender (In)Equity In Global Mental Health Research: A Call To Action, The Women In Global Mental Health Research Group, Kelly Rose-Clarke

Faculty Publications

In this commentary, we build on work by Gurung and colleagues which highlighted gender inequity in the global mental health research workforce in Nepal (Gurung et al., 2021). We seek to increase awareness of the under-representation of women in global mental health research and its consequences, and we call for change. By women, we refer to all people who identify as women, including trans people. The commentary is informed by conversations with women who are global mental health researchers in the Global North and South at various stages of their careers.

Factors Associated With Resilience Among Msw Students In The Face Of The Covid-19 Pandemic, Jose Carbajal, Donna Schuman, Warren Ponder, Christine Bishop, Amber Hall, Kristin Bolton

Faculty Publications

COVID-19 continues to affect the general population, and its impact on MSW students is unknown. Therefore, this study aims to examine resilience, attachment, and other mental health constructs among MSW students during COVID-19. U.S. MSW program directors were emailed the electronic surveys to distribute to their MSW students. Authors evaluated the bivariate relationship between the variables and conducted a multiple hierarchical regression predicting resilience. The findings suggest that individuals with higher levels of resilience have lower levels of depression and PTSD. Finally, attachment avoidance, attachment anxiety, and self-efficacy were statistically significant predictors of resilience in the hierarchical regression. This study …

Short-Term Responses Of Soil Carbon, Nitrogen, And Microbial Biomass To Cover Crop Mixtures And Monocultures, Igor Alexandre De Souza, Amanda B. Daly, Jorg Schnecker, Nicholas D. Warren, Adalfredo Rocha Lobo Jr., Richard G. Smith, Andre Fonseca Brito, A. Stuart Grandy

Faculty Publications

Increasingly, cover crops are being adopted for the purpose of improving soil health, yet the timescale and magnitude by which living annual cover crops might modify soil chemical and biological aspects of soil health is not well understood. At the same time, there is growing interest among farmers in cover crop mixtures due to perceptions that species-rich cover crop communities will enhance soil health relative to monocultures. In a field experiment in southeast New Hampshire, we investigated how groups of cover crops grown as monocultures and mixtures for specific seasonal niches (winter/spring, summer, and fall) influenced levels of soil nitrogen …

Electrically-Evoked Referred Sensations Induce Embodiment Of Rubber Limb, Anthony Nguyen, Brooke Draggoo, Brooklyn Tobias, Payton Dubose, Katharine Polasek

Faculty Publications

Introduction: Electrical stimulation is increasingly relevant in a variety of medical treatments. In this study, the quality of referred sensations evoked using surface electrical stimulation was evaluated using the rubber hand and foot illusions.

Methods: The rubber hand and foot illusions were attempted under 4 conditions: (1) multi-location tapping; (2) one-location tapping; (3) electrical stimulation of sensation referred to the hand or foot; (4) asynchronous control. The strength of each illusion was quantified using a questionnaire and proprioceptive drift, where a stronger response suggested embodiment of the rubber limb.

Results: 45 able-bodied individuals and two individuals with amputations participated in …

Year-Round Weather Alters Nest-Provisioning Rates In A Migratory Owl, Eliza D. Stein, Stephen R. Midway, Brian D. Linkhart

Faculty Publications

As global temperatures and precipitation become more extreme, habitat specialists are at particular risk of being pushed past their environmental tolerance limits. Flammulated Owls (Psiloscops flammeolus) are small migratory owls that breed in temperate conifer forests of western North America. Their highly specialized nesting and foraging requirements make them indicators of ecosystem health. Using 17 years of nest observations, we investigated how annual weather patterns affected Flammulated Owl nesting and foraging behaviors during the breeding season. We used generalized linear models with a changepoint parameter to evaluate nest provisioning and nestling growth rates in years of extreme temperature and precipitation. …

The Mindful First Amendment, Gary Myers

Faculty Publications

The mindfulness movement has begun to play an expanding role in personal well-being and in society more generally. Although there is an active push for mindfulness in law, its primary focus is on ways in which mindfulness techniques can help lawyers in their personal and professional lives. This article explores the possible contributions of mindfulness to the widely recognized challenges facing freedom of speech and freedom of the press in an era of severe cultural and political polarization.

Preliminary Validation Of Digital Photography To Assess The Home Food Environment, Daniela Quan, Isaac Michael, Elizabeth Gollub

Faculty Publications

The home food environment (HFE), the availability and accessibility of foods and food products within the home, has a strong influence on healthy eating behaviors. Studies assessing the HFE commonly utilize a home food inventory (HFI) for data collection. However, this approach tends to be burdensome for participants. This study validated a low-burden digital photo method for assessing the home food environment and confirmed that this method is preferred by participants. Study participants completed an HFI, submitted photos of household foods, then identified preference for the HFI or photo reporting method. Researchers completed an HFI based on each participant’s photo …

Clathrin-Mediated Endocytosis Facilitates The Internalization Of Magnaporthe Oryzae Effectors Into Rice Cells, Ely Oliveira-Garcia, Tej Man Tamang, Jungeun Park, Melinda Dalby, Magdalena Martin-Urdiroz, Clara Rodriguez Herrero, An Hong Vu, Sunghun Park, Nicholas J. Talbot, Barbara Valent

Faculty Publications

Fungi and oomycetes deliver effectors into living plant cells to suppress defenses and control plant processes needed for infection. Little is known about the mechanism by which these pathogens translocate effector proteins across the plasma membrane into the plant cytoplasm. The blast fungus Magnaporthe oryzae secretes cytoplasmic effectors into a specialized biotrophic interfacial complex (BIC) before translocation. Here, we show that cytoplasmic effectors within BICs are packaged into punctate membranous effector compartments that are occasionally observed in the host cytoplasm. Live cell imaging with fluorescently labeled proteins in rice (Oryza sativa) showed that these effector puncta colocalize with the plant …