Digital Commons Network^™

Comparisons Between Rail-Trail Users And Nonusers And Men And Women's Patterns Of Use In A Suburban Community, Philip J. Troped, Ruth P. Saunders, Russell R. Pate

Faculty Publications

Background: Physical activity research on trails is limited. We compared rail-trail users and nonusers on demographics, physical activity, and barriers/concerns about trail use; and described use among men and women. Methods: Four hundred thirteen adults completed a physical activity survey during fall 1998. Chi-square statistics and t-tests were used to compare trail users to nonusers, and men and women on trail use. Results: More trail users (79%) performed recreational physical activity ≥ 3 d/wk, compared to nonusers (47%). Walking was the most common activity for trail users and nonusers. Both groups shared concerns about safe access to the trail …

A Matter Of Life And Death, William E. Richardson

Faculty Publications

No abstract provided.

Egf-Stimulation Activates The Nuclear Localization Signal Of Shp-1, Dandan He, Xi Song, Lijun Liu, David H. Burk, G. Wayne Zhou

Faculty Publications

Protein tyrosine phosphatase SHP-1 plays a critical role in the regulation of a variety of intracellular signaling pathways. SHP-1 is predominantly expressed in the cells of hematopoietic origin, and is recognized as a negative regulator of lymphocyte development and activation. SHP-1 consists of two Src homology 2 (SH2) domains and one protein tyrosine phosphatase (PTP) domain followed by a highly basic C-terminal tail containing tyrosyl phosphorylation sites. It is unclear how the C-terminal tail regulates SHP-1 function. We report the examination of the subcellular localization of a variety of truncated or mutated SHP-1 proteins fused with enhanced green fluorescent protein …

Policymaking By The Administrative Judiciary, Charles H. Koch Jr.

Faculty Publications

No abstract provided.

The Liberal State's Response To Religious Visions Of Education, James G. Dwyer

Faculty Publications

No abstract provided.

The Invisible Pillar Of Gideon, Adam M. Gershowitz

Faculty Publications

In 1996, the State of South Carolina charged Larry McVay with common-law robbery. McVay, who was employed part-time and took home less than $160 per week after taxes, claimed that after paying his basic living expenses he had no money left with which to hire an attorney. A South Carolina court disagreed and denied McVay’s request for appointed counsel. Seven years later, Scott Peterson was arrested for the murder of his wife and unborn child in California. Although Peterson owned a home, drove an expensive SUV, and was carrying $10,000 in cash when he was captured, he claimed to be …

Policymaking By The Administrative Judiciary, Charles H. Koch Jr.

Faculty Publications

No abstract provided.

Should Liability Play A Role In The Social Control Of Biobanks?, Larry I. Palmer

Faculty Publications

No abstract provided.

Those Who Revise And Those Who Revolt, Jo Ann Davidson

Faculty Publications

No abstract provided.

Scale And Shape Issues In Focused Cluster Power For Count Data, Robin C. Puett, Andrew B. Lawson, Allan B. Clark, Tim E. Aldrich, Dwayne E. Porter, Charles E. Feigley, James R. Hébert

Faculty Publications

Background: Interest in the development of statistical methods for disease cluster detection has experienced rapid growth in recent years. Evaluations of statistical power provide important information for the selection of an appropriate statistical method in environmentally-related disease cluster investigations. Published power evaluations have not yet addressed the use of models for focused cluster detection and have not fully investigated the issues of disease cluster scale and shape. As meteorological and other factors can impact the dispersion of environmental toxicants, it follows that environmental exposures and associated diseases can be dispersed in a variety of spatial patterns. This study simulates …

Study Of The Pion Trajectory In The Photoproduction Of Leading Neutrons At Hera, S. Chekanov, M. Derrick, D. Krakauer, J. H. Loizides, S. Magill, S. Miglioranzi, B. Musgrave, J. Repond, R. Yoshida, Margarita C. K. Mattingly, P. Antonioli, G. Bari, M. Basile, L. Bellagamba, D. Boscherini, A. Bruni, G. Bruni, G. Cara Romeo, L. Cifarelli, F. Cindolo, A. Contin, M. Corradi, S. De Pasquale, P. Giusti, G. Iacobucci, A. Margotti, A. Montanari, R. Nania, F. Palmonari, A. Pesci, G. Sartorelli

Faculty Publications

Energetic neutrons produced in ep collisions at HERA have been studied with the ZEUS detector in the photoproduction regime at a mean photon-proton center-of-mass energy of 220 GeV. The neutrons carry a large fraction 0.64

Disrupting Integrin Transmembrane Domain Heterodimerization Increases Ligand Binding Affinity, Not Valency Or Clustering, Bing Hao Luo, Christopher V. Carman, Junichi Takagi, Timothy A. Springer

Faculty Publications

Residues important in the interaction between the 23-residue transmembrane (TM) domains of the integrin αIIb- and β3- subunits were identified by mutating each non-Leu residue to Leu. Leu substitutions of αIIb at G972, G976, and T981, and of β3 at 1693 and G708, increased ligand binding. Substitutions with other amino acids at αIIbG972 and β3G708 could also increase ligand binding. The results are consistent with and extend the helical interface between the integrin α- and β-subunit TM domains previously defined by cysteine scanning and disulfide bond formation. We differentiated between affinity- and valency-based modes of activation by TM domain mutations. …

Haplotypes Produced From Rare Variants In The Promoter And Coding Regions Of Angiotensinogen Contribute To Variation In Angiotensinogen Levels, Xiaofeng Zhu, Laura Fejerman, Amy Luke, Adebowale Adeyemo, Richard S. Cooper

Faculty Publications

The most efficient study design to map genes underlying complex traits will be determined by assumptions about whether the genetic effects are likely to be due to relatively few common variants or multiple rare variants. To examine the possibility that rare variants may influence blood pressure, we sequenced a 6.8 kb region of the angiotensinogen (AGT) gene in 29 male Nigerians with high plasma AGT levels and 28 with low levels. The frequency of haplotypes produced from rare variants in the promoter and coding regions was significantly different between the two groups, and it is unlikely that this difference was …

Universal Service: Problems, Solutions, And Responsive Policies, Allen S. Hammond Iv

Faculty Publications

Affordable access to telecommunications networks is extremely important to all Americans. The federal universal service policy is critical to ensuring affordable access for low income Americans and those living in rural and high cost areas, and on tribal lands. Consequently the nation’s commitment to preserving universal service has been longstanding and continues to this day.

While reform of the telecommunications universal service policy is clearly warranted, ignoring the impact of IP-enabled intermodal competition is counterproductive. In an era of IP-enabled convergence, ultimately, proposals and policies that solely focus on one technology platform will be less successful. Too often they will …

Pronounced Clean, Comfortable, And Good Looking: The Passage Of Mormon Immigrants Through The Port Of Philadelphia, Fred E. Woods

Faculty Publications

We were pronounced clean, comfortable, and good looking. So wrote LDS voyage leader Matthias Cowley after arriving in Philadelphia with a company of foreign Saints in the mid-nineteenth century. At this time, Latter-day Saint European immigrants, obeying the call to come to Zion, were gathering to America by the thousands on the way to their Mormon Mecca in Salt Lake City. They were obeying the call to come to Zion. In 1852, the First Presidency issued the following counsel: "When a people, or individuals, hear the Gospel, obey its first principles, are baptized for the remission of sins, and receive …

Reporting Quality Of Randomized Trials In The Diet And Exercise Literature For Weight Loss, Cheryl A. Gibson, Erik P. Kirk, James D. Lecheminant, Bruce W. Bailey Jr, Guoyuan Huang, Joseph E. Donnelly

Faculty Publications

Background

To adequately assess individual studies and synthesize quantitative research on weight loss studies, transparent reporting of data is required. The authors examined the reporting quality of randomized trials in the weight loss literature, focusing exclusively on subject characteristics as they relate to enrollment, allocation, and follow-up.

Methods

An extensive literature review, which included a computerized search of the MEDLINE database, manual searches of bibliographic references, and cross-referencing of 92 review articles was conducted. A checklist, based on CONSORT recommendations, was used to collect information on whether or not authors reported age, gender, co-morbid disease, medication use, race/ethnicity, and postmenopausal …

Analysis Of The Human Alu Ye Lineage, Abdel Halim Salem, David A. Ray, Dale J. Hedges, Jerzy Jurka, Mark A. Batzer

Faculty Publications

Background: Alu elements are short (∼300 bp) interspersed elements that amplify in primate genomes through a process termed retroposition. The expansion of these elements has had a significant impact on the structure and function of primate genomes. Approximately 10 % of the mass of the human genome is comprised of Alu elements, making them the most abundant short interspersed element (SINE) in our genome. The majority of Alu amplification occurred early in primate evolution, and the current rate of Alu retroposition is at least 100 fold slower than the peak of amplification that occurred 30-50 million years ago. Alu elements …

Indirect Enzyme-Linked Immunosorbent Assay For Detection Of Brucella Melitensis-Specific Antibodies In Goat Milk, N. D. Funk, L. B. Tabatabai, P. H. Elzer, S. D. Hagius, B. M. Martin, L. J. Hoffman

Faculty Publications

Brucella melitensis is the cause of brucellosis in sheep and goats, which often results in abortion. Few cases of B. melitensis infection in goats have occurred in the United States over the last 25 years. However, vigilance must be maintained, as it is for the bovine milk industry, to ensure that brucellosis is not introduced into the U.S. goat population. The objective of this study was to develop a sensitive and specific indirect enzyme-linked immunosorbent assay (iELISA) for the detection of B. melitensis-specific antibodies in goat milk. Brucella salt-extractable protein extract was employed as an antigen, and a horseradish peroxidase-labeled …

Multiplex Polymerase Chain Reaction For Simultaneous Quantitation Of Human Nuclear, Mitochondrial, And Male Y-Chromosome Dna: Application In Human Identification, Jerilyn A. Walker, Dale J. Hedges, Benjamin P. Perodeau, Kate E. Landry, Nadica Stoilova, Meredith E. Laborde, Jaiprakash Shewale, Sudhir K. Sinha, Mark A. Batzer

Faculty Publications

Human forensic casework requires sensitive quantitation of human nuclear (nDNA), mitochondrial (mtDNA), and male Y-chromosome DNA from complex biomaterials. Although many such systems are commercially available, no system is capable of simultaneously quantifying all three targets in a single reaction. Most available methods either are not multiplex compatible or lack human specificity. Here, we report the development of a comprehensive set of human-specific, target-specific multiplex polymerase chain reaction (PCR) assays for DNA quantitation. Using TaqMan-MGB probes, our duplex qPCR for nDNA/mtDNA had a linear quantitation range of 100 ng to 1 pg, and our triplex qPCR assay for nDNA/mtDNA/male Y …

Texture And Microflora Of Vallagret Cheese During Maturation, Kayanush J. Aryana, Zahur Z. Haque

Faculty Publications

Vallagret is a unique Jarlsberg-like cheese that combines characteristics of Cheddar and Swiss cheeses. The objectives of this study were to elucidate the stress and strain behaviour of young (1 week) and mature (20 weeks) vallagret cheese and to enumerate the microflora of young and matured cheeses. The large deformation properties of vallagret cheese were determined using an Instron universal testing machine. Lactococci were enumerated using M17 agar. Lactobacilli and Leuconostoc mesenteroides ssp. cremoris were enumerated on Lactobacillus selective (LBS) agar while the aerobic microorganisms were enumerated using plate count agar. Fracture stress decreased significantly from 0.52 MPa in young …

A Virtual Environment For Remote Testing Of Complex Systems, Loredana Cristaldi, Alessandro Ferrero, Antonello Monti, Ferdinanda Ponci, William Mckay, Roger A. Dougal

Faculty Publications

Complex systems, realized by integration of several components or subsystems, pose specific problems to simulation environments. It is, in fact, desirable to simulate the complex system altogether, and not component by component, since the operation of the single part depends on the surrounding system and an early verification can prevent damages and save time for modifications. The availability of detailed and validated models of the single parts is therefore critical. This task may be difficult to achieve. In fact, in industrial applications, where a system can be a mix of different devices produced by different manufacturers, the physical device may …

The Effect Of Social Desirability And Social Approval On Self-Reports Of Physical Activity, Swann A. Adams, Charles E. Matthews, Cara B. Ebbeling, Charity G. Moore, Joan E. Cunningham, Jeanette Fulton, James R. Hébert

Faculty Publications

The purpose of this investigation was to examine social desirability and social approval as sources of error in three self-reported physical activity assessments using objective measures of physical activity as reference measures. In 1997, women (n = 81) living in Worcester, Massachusetts, completed doubly labeled water measurements and wore an activity monitor for 14 days. They also completed seven interviewer-administered 24-hour physical activity recalls (PARs) and two different self-administered 7-day PARs. Measures of the personality traits “social desirability” and “social approval” were regressed on 1) the difference between physical activity energy expenditure estimated from doubly labeled water and each …

Association Between Dietary Carbohydrates And Body Weight, Yunsheng Ma, Barbara Olendzki, David Chiriboga, James R. Hébert, Youfu Li, Wenjun Li, Mary Jane Campbell, Katherine Gendreau, Ira S. Ockene

Faculty Publications

The role of dietary carbohydrates in weight loss has received considerable attention in light of the current obesity epidemic. The authors investigated the association of body mass index (weight (kg)/height (m)²) with dietary intake of carbohydrates and with measures of the induced glycemic response, using data from an observational study of 572 healthy adults in central Massachusetts. Anthropometric measurements, 7-day dietary recalls, and physical activity recalls were collected quarterly from each subject throughout a 1-year study period. Data were collected between 1994 and 1998. Longitudinal analyses were conducted, and results were adjusted for other factors related to body …

A Regional Food-Frequency Questionnaire For The Us Mississippi Delta, Katherine L. Tucker, Janice Maras, Catherine Champagne, Carol L. Connell, Susan Goolsby, Judith Weber, Sahar Zaghloul, Teresa Carithers, Margaret L. Bogle

Faculty Publications

Objective: To describe food sources of nutrient intake for white and African American adults in the Lower Mississippi Delta (LMD), and their use in the development of a regional food-frequency questionnaire (FFQ) based on an earlier version of the National Cancer Institute's Health Habits and History Questionnaire. Design: We ranked food sources of energy, macronutrients, vitamins and minerals, and examined portion size distributions for 842 white and 857 African American residents aged 19 years and older, using 24-hour dietary intake recall data from a telephone survey of 36 LMD counties. These values were used to develop a regional FFQ, which …

The Structure Of Coral Allene Oxide Synthase Reveals A Catalase Adapted For Metabolism Of A Fatty Acid Hydroperoxide, Michael L. Oldham, Alan R. Brash, Marcia E. Newcomer

Faculty Publications

8R-Lipoxygenase and allene oxide synthase (AOS) are parts of a naturally occurring fusion protein from the coral Plexaura homomalla. AOS catalyses the production of an unstable epoxide (an allene oxide) from the fatty acid hydroperoxide generated by the lipoxygenase activity. Here, we report the structure of the AOS domain and its striking structural homology to catalase. Whereas nominal sequence identity between the enzymes had been previously described, the extent of structural homology observed was not anticipated, given that this enzyme activity had been exclusively associated with the P450 superfamily, and conservation of a catalase fold without catalase activity is unprecedented. …

An International Comparative Study Of Blood Pressure In Populations Of European Vs. African Descent, Richard S. Cooper, Katharina Wolf-Maier, Amy Luke, Adebowale Adeyemo, José Ramon Banega, Terrence Forrester, Simona Giampaoli, Michel Joffres, Mika Kastarinen, Paola Primatesta, Birgitta Stegmayr, Michael Thamm

Faculty Publications

Background: The consistent finding of higher prevalence of hypertension in US blacks compared to whites has led to speculation that African-origin populations are particularly susceptible to this condition. Large surveys now provide new information on this issue. Methods: Using a standardized analysis strategy we examined prevalence estimates for 8 white and 3 black populations (N = 85,000 participants). Results: The range in hypertension prevalence was from 27 to 55% for whites and 14 to 44% for blacks. Conclusions: These data demonstrate that not only is there a wide variation in hypertension prevalence among both racial groups, the rates among blacks …

Studying Multiprotein Complexes By Multisignal Sedimentation Velocity Analytical Ultracentrifugation, Andrea Balbo, Kenneth H. Minor, Carlos A. Velikovsky, Roy A. Mariuzza, Cynthia B. Peterson, Peter Schuck

Faculty Publications

Protein interactions can promote the reversible assembly of multiprotein complexes, which have been identified as critical elements in many regulatory processes in cells. The biophysical characterization of assembly products, their number and stoichiometry, and the dynamics of their interactions in solution can be very difficult. A classical first-principle approach for the study of purified proteins and their interactions is sedimentation velocity analytical ultracentrifugation. This approach allows one to distinguish different protein complexes based on their migration in the centrifugal field without isolating reversibly formed complexes from the individual components. An important existing limitation for systems with multiple components and assembly …

The Use Of Phenomenology For Family Therapy Research: The Search For Meaning, Carla M. Dahl, Pauline Boss

Faculty Publications

No abstract provided.

Expectations Of Executive Mbas, Ernest A. Capozzoli, David E. Gundersen

Faculty Publications

Currently there are over 200 EMBA programs worldwide. These programs have grown in popularity and have increased by over a third in the last three years. Overall, schools are aggressively marketing their EMBA programs, and, as a consequence, prospective EMBA participants have numerous options for EMBA program enrollment. To successfully compete in the current environment, EMBA programs must understand and market to the expectations of prospective EMBAs. This paper explores the suitability of using the Teaching Goals Inventory (TGI) developed by Angelo and Cross (1993) as an instrument to analyze the expectations of EMBA candidates in the United States and …

The Curry/Samara Model And The Model Classrooms Project Background And Research Foundations, Gloria J. Gresham Dr., Ronnie Porter

Faculty Publications

The Curry/Samara Model(CSM) is an integrated, standards based approach to curriculum development that addresses differentiation from three dimensions (content, process & product). CSM is comprised of strategies related to curriculum, instruction and assessment that helps teachers to: (1) complement factual subject matter with rich, global concepts; (2) foster basic and abstract levels of thinking as related to core content; and (3) engage and assess students through traditional as well as innovative, authentic products.