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Examining The Cdcynergy Event Assessment Tool: An Investigation Of The Anthrax Crisis In Boca Raton, Florida, J. J. Mcintyre, Steven J. Venette Sep 2006

Examining The Cdcynergy Event Assessment Tool: An Investigation Of The Anthrax Crisis In Boca Raton, Florida, J. J. Mcintyre, Steven J. Venette

Faculty Publications

This paper examines the dependability of the Event Assessment Tool over time. The latter is part of a CD-ROM-Emergency Risk Communication CDCynergy-distributed primarily to public information officers in the United States by the Centers for Disease Control and Prevention. The Event Assessment Tool is designed to aid emergency professionals in identifying the magnitude of a crisis event and to suggest appropriate actions to confront such a situation. Applied twice during the 2001 anthrax bioterrorism crisis in Boca Raton, Florida, the tool functioned in a binary manner by first indicating a moderate crisis level (on 4 October) and then four days …

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Intestinal Enzymes During Malnutrition & Infection In Rabbits, Sufia Islam, Amal K. Mitra, Ashish K. Chowdhury, Nur Haque Alam Sep 2006

Intestinal Enzymes During Malnutrition & Infection In Rabbits, Sufia Islam, Amal K. Mitra, Ashish K. Chowdhury, Nur Haque Alam

Faculty Publications

Background & objectives: Malnutrition plays an important role in the intestinal absorption of nutrients. However, reports are not consistent whether intestinal enzymes are decreased in the presence of malnutrition. It is also not clear whether simultaneous presence of malnutrition and infection adds to the problem of malabsorption of nutrients. The aim of the present study was to determine intestinal functions in terms of concentrations of disaccharidase enzymes during diarrhoea and protein energy malnutrition. Methods: Concentrations of three disaccharidase enzymes, namely maltase, sucrase and lactase were measured in nine energy-restricted and five control rabbits during diarrhoea induced by rabbit diarrhoeagenic Escherichia …

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Multicultural Competency Instrumentation: A Review And Analysis Of Reliability Generalization, Todd W. Dunn, Timothy B. Smith, Jared A. Montoya Sep 2006

Multicultural Competency Instrumentation: A Review And Analysis Of Reliability Generalization, Todd W. Dunn, Timothy B. Smith, Jared A. Montoya

Faculty Publications

This article reviews the internal consistency reliability of multicultural competency instrumentation. Additional psychometric properties are qualitatively reviewed for commonly used instruments and 5 other measures of multicultural competency that have not previously been reviewed in the literature. Results indicate that the most widely used instruments have generally acceptable internal consistency reliability across different populations and settings. Limitations of research conducted on multicultural counseling competencies are identified, and recommendations for future research are provided.

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Hiv-1 Dna/Mva Vaccination Reduces The Per Exposure Probability Of Infection During Repeated Mucosal Shiv Challenges, Dennis Ellenberger, Ronald A. Otten, Bin Li, Michael Aidoo, I. Vanessa Rodriguez, Carlos A. Sariol, Melween Martinez, Michael Monsour, Linda Wyatt, Michael G. Hudgens, Edmundo Kraiselburd, Bernard Moss, Harriet Robinson, Thomas Folks, Salvatore Butera Aug 2006

Hiv-1 Dna/Mva Vaccination Reduces The Per Exposure Probability Of Infection During Repeated Mucosal Shiv Challenges, Dennis Ellenberger, Ronald A. Otten, Bin Li, Michael Aidoo, I. Vanessa Rodriguez, Carlos A. Sariol, Melween Martinez, Michael Monsour, Linda Wyatt, Michael G. Hudgens, Edmundo Kraiselburd, Bernard Moss, Harriet Robinson, Thomas Folks, Salvatore Butera

Faculty Publications

Historically, HIV vaccines specifically designed to raise cellular immunity resulted in protection from disease progression but not infection when tested in monkeys challenged with a single high virus exposure. An alternative approach, more analogous to human sexual exposures, is to repetitively challenge immunized monkeys with a much lower dose of virus until systemic infection is documented. Using these conditions to mimic human sexual transmission, we found that a multi-protein DNA/MVA HIV-1 vaccine is indeed capable of protecting rhesus monkeys against systemic infection when repeatedly challenged with a highly heterologous immunodeficiency virus (SHIV). Furthermore, this repetitive challenge approach allowed us to …

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Religion And Family Relational Health: An Overview And Conceptual Model, Loren Marks Aug 2006

Religion And Family Relational Health: An Overview And Conceptual Model, Loren Marks

Faculty Publications

This paper presents a review of research addressing religion and family relational health. Strengths of the extant data include the correlation of three dimensions of religious experience (religious practices, religious beliefs, and religious community) with certain aspects of mother–child, father–child, and marital relationships and specific connections between the three dimensions of religious experience and family relationships are identified. Key weaknesses in the research at present include a paucity of research examining the hows, whys, and processes involved behind identified religion–family correlations and a lack of data on non-nuclear families, families of color, interfaith families, and non-Christian religions including Judaism and …

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Interaction Of Ice Storms And Management Practices On Current Carbon Sequestration In Forests With Potential Mitigation Under Future Co2 Atmosphere, Heather R. Mccarthy, Ram Oren, Hyun-Seok Kim, Kurt H. Johnsen, Chris Maier, Seth G. Pritchard, Micheal Davis Aug 2006

Interaction Of Ice Storms And Management Practices On Current Carbon Sequestration In Forests With Potential Mitigation Under Future Co2 Atmosphere, Heather R. Mccarthy, Ram Oren, Hyun-Seok Kim, Kurt H. Johnsen, Chris Maier, Seth G. Pritchard, Micheal Davis

Faculty Publications

[1] Ice storms are disturbance events with potential impacts on carbon sequestration. Common forest management practices, such as fertilization and thinning, can change wood and stand properties and thus may change vulnerability to ice storm damage. At the same time, increasing atmospheric CO2 levels may also influence ice storm vulnerability. Here we show that a nonintensively managed pine plantation experienced a ∼250 g C m−2 reduction in living biomass during a single storm, equivalent to ∼30% of the annual net ecosystem carbon exchange of this ecosystem. Drawing on weather and damage survey data from the entire storm cell, …

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A Chemomechanical Polymer That Functions In Blood Plasma With High Glucose Selectivity, George K. Samoei, Weihua Wang, Jorge O. Escobedo, Xiangyang Xu, Hans Jörg Schneider, Robert L. Cook, Robert M. Strongin Aug 2006

A Chemomechanical Polymer That Functions In Blood Plasma With High Glucose Selectivity, George K. Samoei, Weihua Wang, Jorge O. Escobedo, Xiangyang Xu, Hans Jörg Schneider, Robert L. Cook, Robert M. Strongin

Faculty Publications

(Figure Presented) See the shrink: Systematic modification of poly(methyl methacrylate) leads to a chemomechanical polymer that selectively contracts in the presence of glucose at physiological levels in human blood plasma. The polymer also exhibits good reversibility allowing continuous expansion-contraction cycles. © 2006 Wiley-VCH Verlag GmbH & Co. KGaA.

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Empowered Through Labor And Buttressing Their Communities: Mayan Women And Coastal Migration, 1875 - 1965, David Carey Aug 2006

Empowered Through Labor And Buttressing Their Communities: Mayan Women And Coastal Migration, 1875 - 1965, David Carey

Faculty Publications

No abstract provided.

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Rickettsia Felis From Cat Fleas: Isolation And Culture In A Tick-Derived Cell Line, Walairat Pornwiroon, Susan S. Pourciau, Lane D. Foil, Kevin R. Macaluso Aug 2006

Rickettsia Felis From Cat Fleas: Isolation And Culture In A Tick-Derived Cell Line, Walairat Pornwiroon, Susan S. Pourciau, Lane D. Foil, Kevin R. Macaluso

Faculty Publications

Rickettsia felis, the etiologic agent of spotted fever, is maintained in cat fleas by vertical transmission and resembles other tick-borne spotted fever group rickettsiae. In the present study, we utilized an Ixodes scapularis-derived tick cell line, ISE6, to achieve isolation and propagation of R. felis. A cytopathic effect of increased vacuolization was commonly observed in R. felis-infected cells, while lysis of host cells was not evident despite large numbers of rickettsiae. Electron microscopy identified rickettsia-like organisms in ISE6 cells, and sequence analyses of portions of the citrate synthase (gltA), 16S rRNA, Rickettsia genus-specific 17-kDa antigen, and spotted fever group-specific outer …

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The Drosophila Boundary Element-Associated Factors Beaf-32a And Beaf-32b Affect Chromatin Structure, Matthew K. Gilbert, Yian Yee Tan, Craig M. Hart Aug 2006

The Drosophila Boundary Element-Associated Factors Beaf-32a And Beaf-32b Affect Chromatin Structure, Matthew K. Gilbert, Yian Yee Tan, Craig M. Hart

Faculty Publications

Binding sites for the Drosophila boundary element-associated factors BEAF-32A and -32B are required for the insulator activity of the scs' insulator. BEAF binds to hundreds of sites on polytene chromosomes, indicating that BEAF-utilizing insulators are an important class in Drosophila. To gain insight into the role of BEAF in flies, we designed a transgene encoding a dominant-negative form of BEAF under GAL4 UAS control. This BID protein encompasses the BEAF self-interaction domain. Evidence is provided that BID interacts with BEAF and interferes with scs' insulator activity and that BEAF is the major target of BID in vivo. BID expression during …

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Health In Cuba, Richard S. Cooper, Joan F. Kennelly, Pedro Orduñez-Garcia Aug 2006

Health In Cuba, Richard S. Cooper, Joan F. Kennelly, Pedro Orduñez-Garcia

Faculty Publications

The poorer countries of the world continue to struggle with an enormous health burden from diseases that we have long had the capacity to eliminate. Similarly, the health systems of some countries, rich and poor alike, are fragmented and inefficient, leaving many population groups underserved and often without health care access entirely. Cuba represents an important alternative example where modest infrastructure investments combined with a well-developed public health strategy have generated health status measures comparable with those of industrialized countries. Areas of success include control of infectious diseases, reduction in infant mortality, establishment of a research and biotechnology industry, and …

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Reflections From The Introduction Of Blogs And Rss Feeds Into A Preservice Instructional Technology Course, Bruce Gabbitas, Charles R. Graham, Richard E. West, Geoffrey Wright Aug 2006

Reflections From The Introduction Of Blogs And Rss Feeds Into A Preservice Instructional Technology Course, Bruce Gabbitas, Charles R. Graham, Richard E. West, Geoffrey Wright

Faculty Publications

In this paper we report our experiences using blogs and RSS technology to teach over 800 preservice students in an introductory instructional technology course over the course of three semesters. Our main purpose for using blogs and RSS feeds was to promote critical reflection, student collaboration, and professional development. Through focus group interviews and class surveys, we discovered both effective and ineffective methods for integrating blogs and RSS feeds into a course. This paper will reflect on these findings and provide practical ideas for overcoming the challenges we faced in implementing blogs and RSS feeds as effective teaching and learning …

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Measuring The Effects Of Salinity Stress In The Red Mangrove, Rhizophora Mangle L., Patrick D. Biber Aug 2006

Measuring The Effects Of Salinity Stress In The Red Mangrove, Rhizophora Mangle L., Patrick D. Biber

Faculty Publications

The mangrove habitat exhibits many unique physical features, one of the most important of which is a salinity gradient. Photosynthetic rates, as measured by leaf stomatal conductance and leaf chlorophyll fluorescence induction, were tested as indicators of salinity stress in seedlings of the red mangrove, Rhizophora mangle, grown under five different salinity levels: 0, 15, 30, 45, and 60 parts per thousand. Photosynthetic gas exchange (measured by stomatal conductance), as well as the light reaction of photosynthesis (measured by chlorophyll fluorescence) were found to decrease as salinity increased. The use of leaf stomatal conductance and chlorophyll fluorescence as a …

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The Clinical Research Forum And Association Of American Physicians Disagree With Criticism Of The Nih Roadmap, William Crowley Jr, John Courtney, Larry Jameson, Herbert Pardes, Jay Moskowitz, Eugene Orringer, Arthur Rubenstein, Alastair Wood, Richard Rettig, Dennis Ausiello, David Brenner, Francis Collins, Jack Elias, Warner Greene, Ralph Horowitz, Larry Jameson, Elliott Kieff, Craig Thompson, Judith Swain Aug 2006

The Clinical Research Forum And Association Of American Physicians Disagree With Criticism Of The Nih Roadmap, William Crowley Jr, John Courtney, Larry Jameson, Herbert Pardes, Jay Moskowitz, Eugene Orringer, Arthur Rubenstein, Alastair Wood, Richard Rettig, Dennis Ausiello, David Brenner, Francis Collins, Jack Elias, Warner Greene, Ralph Horowitz, Larry Jameson, Elliott Kieff, Craig Thompson, Judith Swain

Faculty Publications

No abstract provided.

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Early Predictors Of Self-Regulation In Middle Childhood, Rebecca A. Colman, Sam A. Hardy, Myesha Albert, Marcela Raffaelli, Lisa J. Crockett Jul 2006

Early Predictors Of Self-Regulation In Middle Childhood, Rebecca A. Colman, Sam A. Hardy, Myesha Albert, Marcela Raffaelli, Lisa J. Crockett

Faculty Publications

The present study examined the contribution of caregiving practices at ages 4–5 (Time 1) to children’s capacity for self regulation at ages 8–9 (Time 2). The multiethnic sample comprised 549 children of National Longitudinal Survey of Youth (NLSY) participants. High levels of maternal warmth and low levels of physically punitive discipline at Time 1 were associated with a greater capacity for self-regulation at Time 2. These associations remained signifi cant once initial levels of self-regulation were taken into account, indicating that the development of self-regulation is open to caregiver infl uence during childhood. Neither child gender nor ethnicity moderated the …

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Classical Biological Control Of The Papaya Mealybug, Paracoccus Marginatus (Hemiptera: Pseudococcidae) In The Republic Of Palau, R. Muniappan, D. E. Meyerdirk, F. M. Sengebau, D. D. Berringer, G. V.P. Reddy Jul 2006

Classical Biological Control Of The Papaya Mealybug, Paracoccus Marginatus (Hemiptera: Pseudococcidae) In The Republic Of Palau, R. Muniappan, D. E. Meyerdirk, F. M. Sengebau, D. D. Berringer, G. V.P. Reddy

Faculty Publications

The papaya mealybug (PM), Paracoccus marginatus Williams and Granara de Willink (Hemiptera: Pseudococcidae), a pest in Central America and the Caribbean, was noted to have established on Palau in March 2003 and was causing serious damage to papaya, plumeria, hibiscus, and other plants. The parasitoids Anagyrus loecki Noyes, Pseudleptomastix mexicana Noyes and Schauff, and Acerophagus papayae Noyes and Schauff (Hymenoptera: Encyrtidae) totaling 24,586 were imported from Puerto Rico and field released in Palau from August 2003 to June 2004. Anagyrus loecki and A. papayae appear to be promising biological control agents of PM in Palau. No field recovery of P. …

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Identification Of Clustered Yy1 Binding Sites In Imprinting Control Regions, Jeong Do Kim, Angela K. Hinz, Anne Bergmann, Jennifer M. Huang, Ivan Ovcharenko, Lisa Stubbs, Joomyeong Kim Jul 2006

Identification Of Clustered Yy1 Binding Sites In Imprinting Control Regions, Jeong Do Kim, Angela K. Hinz, Anne Bergmann, Jennifer M. Huang, Ivan Ovcharenko, Lisa Stubbs, Joomyeong Kim

Faculty Publications

Mammalian genomic imprinting is regulated by imprinting control regions (ICRs) that are usually associated with tandem arrays of transcription factor binding sites. In this study, the sequence features derived from a tandem array of YY1 binding sites of Peg3-DMR (differentially methylated region) led us to identify three additional clustered YY1 binding sites, which are also localized within the DMRs of Xist, Tsix, and Nespas. These regions have been shown to play a critical role as ICRs for the regulation of surrounding genes. These ICRs have maintained a tandem array of YY1 binding sites during mammalian evolution. The in vivo binding …

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Eminent Domain Reform In Missouri: A Legislative Memoir, Dale A. Whitman Jul 2006

Eminent Domain Reform In Missouri: A Legislative Memoir, Dale A. Whitman

Faculty Publications

The Missouri General Assembly, like a number of other state legislatures, undertook to reform its statutes relating to eminent domain during the 2006 legislative session. This article is the story of that effort and an analysis of the result. I write from a personal perspective. I was fortunate to have been personally involved in many of the decisions that were made as the bill, House Bill 1944, made its was through the legislative process. This opportunity was, I think, fairly unusual for a law professor; in thirty-seven years of teaching property law, I had never previously been so closely engaged …

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Biocatalytic And Antimetastatic Studies Of The Marine Cembranoids Sarcophine And 2-Epi-16-Deoxysarcophine, Swapnali S. Sawant, Diaa T.A. Youssef, Jane Reiland, Melissa Ferniz, Dario Marchetti, Khalid A. El Sayed Jul 2006

Biocatalytic And Antimetastatic Studies Of The Marine Cembranoids Sarcophine And 2-Epi-16-Deoxysarcophine, Swapnali S. Sawant, Diaa T.A. Youssef, Jane Reiland, Melissa Ferniz, Dario Marchetti, Khalid A. El Sayed

Faculty Publications

The soft coral Sarcophyton glaucum is a rich resource of several bioactive cembranoids. Sarcophytol A (1) and sarcophine (2) are cembranoid diterpenes reported from this soft coral and extensively investigated for their cancer chemopreventive properties. This study aimed at investigating the antimetastatic potential of the major cembranoids, sarcophine (2) and 2-epi-16-deoxysarcophine (3), from the Red Sea soft coral S. glaucum. Biocatalytic transformation of 3 using Rhizopus stolonifer ATCC 6227a and Absidia spinosa ATCC 6648 afforded four new metabolites, 5-7 and 9, along with the known 9α-hydroxysarcophine (8). Sarcophine, 2-epi-16-deoxysarcophine, and metabolites 5-9 revealed significant antimetastatic activity against the highly metastatic …

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Workplace Blogs And Workers' Privacy, Rafael Gely, Leonard Bierman Jul 2006

Workplace Blogs And Workers' Privacy, Rafael Gely, Leonard Bierman

Faculty Publications

In this article we focus on a related issue. We discuss the development of blogs, and the virtual “space” where blogs and bloggers interact the “blogosphere” and their impact on the issue of workers' privacy. To some extent it would seem a bit of a contradiction to talk about privacy and blogging in the same article. Blogging, as we will discuss below, does not appear to be the most private of enterprises. There are, we argue, a number of interesting privacy issues raised by the development of blogs as an employee communication tool and by the way employers have reacted …

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Due Process And Punitive Damages: The Error Of Federal Excessiveness Jurisprudence, A. Benjamin Spencer Jul 2006

Due Process And Punitive Damages: The Error Of Federal Excessiveness Jurisprudence, A. Benjamin Spencer

Faculty Publications

The Supreme Court, in a line of several cases over the past decade, has established a rigorous federal constitutional excessiveness review for punitive damages awards based on the Due Process Clause. As a matter of substantive due process, says the Court, punitive awards must be evaluated by three "guideposts" set forth in BMW of North America v. Gore: the degree of reprehensibility of the defendant's conduct, the ratio between punitive and compensatory damages, and a comparison of the amount of punitive damages to any "civil or criminal penalties that could be imposed for comparable misconduct." Following up on this pronouncement …

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Response - Jay Katz: From Harms To Risks, Larry I. Palmer Jul 2006

Response - Jay Katz: From Harms To Risks, Larry I. Palmer

Faculty Publications

No abstract provided.

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The Adventist Theologian, The Three Angels’ Messages, And The Unity Of The Church, P. Gerard Damsteegt Jul 2006

The Adventist Theologian, The Three Angels’ Messages, And The Unity Of The Church, P. Gerard Damsteegt

Faculty Publications

This paper is written in the context of God’s mandate to the Seventh-day Adventist Church. This mandate calls for Seventh-day Adventists to proclaim the great commission, focusing on the three angels’ messages of Revelation 14. The paper focuses especially what this means for Adventist theologians.

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Lanthanide Complexes As Fluorescent Indicators For Neutral Sugars And Cancer Biomarkers, Onur Alptürk, Oleksandr Rusin, Sayo O. Fakayode, Weihua Wang, Jorge O. Escobedo, Isiah M. Warner, William E. Crowe, Vladimir Král, Jeff M. Pruet, Robert M. Strongin Jun 2006

Lanthanide Complexes As Fluorescent Indicators For Neutral Sugars And Cancer Biomarkers, Onur Alptürk, Oleksandr Rusin, Sayo O. Fakayode, Weihua Wang, Jorge O. Escobedo, Isiah M. Warner, William E. Crowe, Vladimir Král, Jeff M. Pruet, Robert M. Strongin

Faculty Publications

Simple water-soluble lanthanum and europium complexes are effective at detecting neutral sugars as well as glycolipids and phospholipids. In solutions at physiologically relevant pH the fluorescent lanthanum complex binds neutral sugars with apparent binding constants comparable to those of arylboronic acids. Interference from commonly occurring anions is minimal. The europium complex detects sialic acid-containing gangliosides at pH 7.0 over an asialoganglioside. This selectivity is attributed, in large part, to the cooperative complexation of the oligosaccharide and sialic acid residues to the metal center, based on analogous prior studies. In MeOH, lysophosphatidic acid (LPA), a biomarker for several pathological conditions including …

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Stat5 Activators Modulate Acyl Coa Oxidase (Aox) Expression In Adipocytes And Stat5a Binds To The Aox Promoter In Vitro, Ann A. Coulter, Jacqueline M. Stephens Jun 2006

Stat5 Activators Modulate Acyl Coa Oxidase (Aox) Expression In Adipocytes And Stat5a Binds To The Aox Promoter In Vitro, Ann A. Coulter, Jacqueline M. Stephens

Faculty Publications

Growth hormone (GH) diminishes adipose tissue mass in vivo and prolactin (PRL) can also modulate adipocyte metabolism. Both GH and PRL are potent activators of STAT5 and exert a variety of effects on adipocyte gene expression. In this study, we have demonstrated that GH and PRL increase the mRNA of acyl CoA oxidase in 3T3-L1 adipocytes. We also identified seven putative STAT elements in the murine AOX promoter. We observed that GH modulates protein binding to the majority of these promoter elements. However, GH induced very potent binding to -1841 to -1825 of the murine AOX promoter. EMSA supershift analysis …

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Criterion Validity Of The Pittsburgh Sleep Quality Index: Investigation In A Non-Clinical Sample, Michael A. Grandner, Daniel F. Kripke, In-Young Yoon, Shawn D. Youngstedt Jun 2006

Criterion Validity Of The Pittsburgh Sleep Quality Index: Investigation In A Non-Clinical Sample, Michael A. Grandner, Daniel F. Kripke, In-Young Yoon, Shawn D. Youngstedt

Faculty Publications

The objective of this study was to investigate the reliability and validity of the Pittsburgh Sleep Quality Index (PSQI) in a non-clinical sample consisting of younger and older adults. There has been little research validating the PSQI with respect to multinight recording as with actigraphy, and more validation is needed in samples not specifically selected for clinical disturbance. Also, the degree to which the PSQI scores may reflect depressive symptoms versus actual sleep disturbance remains unclear. One-hundred and twelve volunteers (53 younger and 59 older) were screened for their ability to perform treadmill exercises; inclusion was not based on sleep …

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Origin And Health Impacts Of Emissions Of Toxic By-Products And Fine Particles From Combustion And Thermal Treatment Of Hazardous Wastes And Materials, Stephania A. Cormier, Slawo Lomnicki, Wayne Backes, Barry Dellinger Jun 2006

Origin And Health Impacts Of Emissions Of Toxic By-Products And Fine Particles From Combustion And Thermal Treatment Of Hazardous Wastes And Materials, Stephania A. Cormier, Slawo Lomnicki, Wayne Backes, Barry Dellinger

Faculty Publications

High-temperature, controlled incineration and thermal treatment of contaminated soils, sediments, and wastes at Superfund sites are often preferred methods of remediation of contaminated sites under the Comprehensive Environmental Response, Compensation, and Liability Act of 1980 and related legislation. Although these methods may be executed safely, formation of toxic combustion or reaction by-products is still a cause of concern. Emissions of polycyclic aromatic hydrocarbons (PAHs); chlorinated hydrocarbons (CHCs), including polychlorinated dibenzo-p-dioxins and dibenzofurans; and toxic metals (e.g., chromium VI) have historically been the focus of combustion and health effects research. However, fine particulate matter (PM) and ultrafine PM, which have been …

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Pivotal Advance: Eosinophil Infiltration Of Solid Tumors Is An Early And Persistent Inflammatory Host Response, Stephania A. Cormier, Anna G. Taranova, Carrie Bedient, Thanh Nguyen, Cheryl Protheroe, Ralph Pero, Dawn Dimina, Sergei I. Ochkur, Katie O'Neill, Dana Colbert, Theresa R. Lombari, Stephanie Constant, Michael P. Mcgarry, James J. Lee, Nancy A. Lee Jun 2006

Pivotal Advance: Eosinophil Infiltration Of Solid Tumors Is An Early And Persistent Inflammatory Host Response, Stephania A. Cormier, Anna G. Taranova, Carrie Bedient, Thanh Nguyen, Cheryl Protheroe, Ralph Pero, Dawn Dimina, Sergei I. Ochkur, Katie O'Neill, Dana Colbert, Theresa R. Lombari, Stephanie Constant, Michael P. Mcgarry, James J. Lee, Nancy A. Lee

Faculty Publications

Tumor-associated eosinophilia has been observed in numerous human cancers and several tumor models in animals; however, the details surrounding this eosinophilia remain largely undefined and anecdotal. We used a B16-F10 melanoma cell injection model to demonstrate that eosinophil infiltration of tumors occurred from the earliest palpable stages with significant accumulations only in the necrotic and capsule regions. Furthermore, the presence of diffuse extracellular matrix staining for eosinophil major basic protein was restricted to the necrotic areas of tumors, indicating that eosinophil degranulation was limited to this region. Antibody-mediated depletion of CD4+ T cells and adoptive transfer of eosinophils suggested, respectively, …

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Positive Selection On Nucleotide Substitutions And Indels In Accessory Gland Proteins Of The Drosophila Pseudoobscura Subgroup, Sheri Dixon Schully, Michael E. Hellberg Jun 2006

Positive Selection On Nucleotide Substitutions And Indels In Accessory Gland Proteins Of The Drosophila Pseudoobscura Subgroup, Sheri Dixon Schully, Michael E. Hellberg

Faculty Publications

Genes encoding reproductive proteins often diverge rapidly due to positive selection on nucleotide substitutions. While this general pattern is well established, the extent to which specific reproductive genes experience similar selection in different clades has been little explored, nor have possible targets of positive selection other than nucleotide substitutions, such as indels, received much attention. Here, we inspect for the signature of positive selection in the genes encoding five accessory gland proteins (Acps) (Acp26Aa, Acp32CD, Acp53Ea, Acp62F, and Acp70A) originally described from Drosophila melanogaster but with recognizable orthologues in the D. pseudoobscura subgroup. We compare patterns of selection within the …

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Initiation Of Apoptosis And Autophagy By Photodynamic Therapy, David Kessel, M. Graça H. Vicente, John J. Reiners Jun 2006

Initiation Of Apoptosis And Autophagy By Photodynamic Therapy, David Kessel, M. Graça H. Vicente, John J. Reiners

Faculty Publications

Background and Objectives: This study was designed to examine modes of cell death after photodynamic therapy (PDT). Study Design: Murine leukemia L1210 cells and human prostate Bax-deficient DU145 cells were examined after PDT-induced photodamage to the endoplasmic reticulum (ER). Phase contrast, fluorescence and electron microscopy were used to identify changes in cellular morphology, chromatin condensation, loss of mitochondrial membrane potential, and formation of phagolysosomes. Western blots were used to assess the processing of LC3-I to LC3-II, a marker for autophagy. Inhibitors of apoptosis and/or autophagy were used to delineate the contributions of the two pathways to the effects of PDT. …

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