Digital Commons Network^™

The Effect Of Flame Structure On Soot Formation And Transport In Turbulent Nonpremixed Flames Using Direct Numerical Simulation, David O. Lignell, Jacqueline H. Chen, Philip J. Smith, Tianfeng Lu, Chung K. Law

Faculty Publications

Direct numerical simulations of a two-dimensional, nonpremixed, sooting ethylene flame are performed to examine the effects of soot–flame interactions and transport in an unsteady configuration. A 15-step, 19-species (with 10 quasi-steady species) chemical mechanism was used for gas chemistry, with a two-moment, four-step, semiempirical soot model. Flame curvature is shown to result in flames that move, relative to the fluid, either toward or away from rich soot formation regions, resulting in soot being essentially convected into or away from the flame. This relative motion of flame and soot results in a wide spread of soot in the mixture fraction coordinate. …

Associations Between Shyness And Internalizing Behaviors, Externalizing Behaviors, And Relationships During Emerging Adulthood, Larry J. Nelson, Laura M. Padilla-Walker, Sarah Badger, Carolyn Mcnamara Barry, Jason S. Carroll, Stephanie D. Madsen

Faculty Publications

Many studies have documented the ways in which shyness can be a barrier to personal well-being and social adjustment throughout childhood and adolescence; however, less is known regarding shyness in emerging adulthood. Shyness as experienced during emerging adulthood may continue to be a risk factor for successful development. The purpose of this study was to compare shy emerging adults with their non-shy peers in (a) internalizing behaviors, (b) externalizing behaviors, and (c) close relationships. Participants included 813 undergraduate students (500 women, 313 men) from a number of locations across the United States. Results showed that relatively shy emerging adults, both …

The Influence Of Culture On Negotiations In South Africa: An Attempt To Promote International Collaborative Dialogue And Research, Judy Rashid, Sharron K. Jenkins Ph.D.

Faculty Publications

This article explores the intersection of culture and negotiation practices during the international development of the AIDS Online International (AOI) project in South Africa. Developed by Dr. Sharron Jenkins as a cross-university, research-based HIV/AIDS education initiative, the AOI course aimed to increase college students' awareness of HIV prevention and to foster global dialogue. In August 2007, faculty from the U.S. engaged in collaborative planning sessions with South African institutions in Durban and Johannesburg. The article highlights how cultural factors—such as negotiation goals, attitudes, agreement-building styles, and team organization—shaped the dynamics of these international meetings. Drawing on Salacuse’s ten cultural negotiation …

Field Studies Of Anoxic Conditions In The Baltic Sea During The Cruise Of R/V Professor Albrecht Penck In July 2006, G. Jost, B. Clement, S. V. Pakhomova, E. V. Yakushev

Faculty Publications

No abstract provided.

Agreement Between Student-Reported And Proxy-Reported Physical Activity Questionnaires, Marsha Dowda, Russell R. Pate, James F. Sallis, Patty S. Freedson, Wendell C. Taylor, John R. Sirard, Stewart G. Trost

Faculty Publications

Parents and 531 students (46% males, 78% white) completed equivalent questionnaires. Agreement between student and parent responses to questions about hypothesized physical activity (PA) correlates was assessed. Relationships between hypothesized correlates and an objective measure of student's moderate-to-vigorous physical activity (MVPA) in a subset of 177 students were also investigated. Agreement between student and parent ranged from r=.34 to .64 for PA correlates. Spearman correlations between MVPA and PA correlates ranged from -.04 to .21 for student report and -.14 to .32 for parent report, and there were no statistical differences for 8 out of 9 correlations between parent …

Assessment Of Genetic Diversity In The Usda And Cip-Fao International Nursery Collections Of Quinoa (Chenopodium Quinoa Willd.) Using Microsatellite Markers, S. A. Christensen, D. B. Pratt, C. Pratt, P. T. Nelson, M. R. Stevens, Eric N. Jellen, Craig E. Coleman, Daniel J. Fairbanks, A. Bonifacio, Michael J. Maughan

Faculty Publications

Quinoa (Chenopodium quinoa Willd.) is a staple food crop for millions of impoverished rural inhabitants of Andean South America where it has been cultivated for millennia. Interest in quinoa, due largely to its superior nutritional characteristics, is fuelling a growing export market and has led to an increased focus on genetic research and the development of quinoa breeding programmes throughout South America. The success of these breeding programmes will rely heavily on the development of core germplasm collections and germplasm conservation. We report the development of a set of fluorescence-tagged microsatellite molecular markers that can be used to characterize genetic …

Hiv/Aids Drugs For Sub-Saharan Africa: How Do Brand And Generic Supply Compare?, Colleen Chien

Faculty Publications

Significant quantities of antiretroviral drugs (ARVs) to treat HIV/AIDS have been procured for Sub-Saharan Africa for the first time in their 20-year history. This presents a novel opportunity to empirically study the roles of brand and generic suppliers in providing access to ARVs.

An observational study of brand and generic supply based on a dataset of 2,162 orders of AIDS drugs for Sub-Saharan Africa reported to the Global Price Reporting Mechanism at the World Health Organization from January 2004-March 2006 was performed. Generic companies supplied 63% of the drugs studied, at prices that were on average about a third of …

Does State Certification Or Licensure Influence Outpatient Substance Abuse Treatment Program Practices?, Jamie Chriqui, Yvonne Terry-Mcelrath, Duane C. Mcbride, S Eidson, Curtis J. Vanderwaal

Faculty Publications

In the United States, state governments legally authorize outpatient substance abuse treatment programs. In some states, programs are certified or accredited (ideal standards). Other states license programs (minimal standards). Additionally, some states authorize programs through "deemed status", which is afforded to programs attaining accreditation from a national accrediting body. Primary legal research and the National Survey of Substance Abuse Treatment Services' (N-SSATS) data were used to examine the relationships between state authorization type (certification/accreditation vs licensure with and without deemed status) and outpatient treatment program practices. Programs in certification/accreditation (vs licensure) states had significantly higher odds of offering wrap-around and …

An Ancestral Variant Of Secretogranin Ii Confers Regulation By Phox2 Transcription Factors And Association With Hypertension, Gen Wen, Jennifer Wessel, Weidong Zhou, Georg B. Ehret, Fangwen Rao, Mats Stridsberg, Sushil K. Mahata, Peter M. Gent, Madhusudan Das, Richard S. Cooper, Aravinda Chakravarti, Huilin Zhou, Nicholas J. Schork, Daniel T. O'Connor, Bruce A. Hamilton

Faculty Publications

Granins regulate secretory vesicle formation in neuroendocrine cells and granin-derived peptides are co-released with neurotransmitters as modulatory signals at sympathetic sites. We report evidence for association between a regulatory polymorphism in Secretogranin II (SCG2) and hypertension in African-American subjects. The minor allele is ancestral in the human lineage and is associated with disease risk in two case-control studies and with elevated blood pressure in a separate familial study. Mechanistically, the ancestral allele acts as a transcriptional enhancer in cells that express endogenous Scg2, whereas the derived allele does not. ARIX (PHOX2A) and PHOX2B are identified as potential transactivating factors by …

Structure And Mechanism Of The Genomically Encoded Fosfomycin Resistance Protein, Fosx, From Listeria Monocytogenes, Kerry L. Fillgrove, Svetlana Pakhomova, Matthew R. Schaab, Marcia E. Newcomer, Richard N. Armstrong

Faculty Publications

The fosfomycin resistance protein, FosX, catalyzes the hydration of the antibiotic fosfomycin, (1R,25)-epoxypropylphosphonic acid. Genes encoding the enzyme are found in several pathogenic microorganisms. The structure and mechanism of action of the genomically encoded FosX enzyme from Listeria monocytogenes (FosXLMATCC) obtained from the American Type Culture Collection are reported. The gene harbors 31 point mutations, and as a consequence, the protein differs in 10 amino acid residues from the previously reported FosX encoded in the genome of the EGD strain of L. monocytogenes (FosXLMEGD). The FosXLMATCC enzyme is shown to catalyze the addition of water to the C1 position of …

A Relationship Between Us Healthcare Worker Smallpox Vaccination Rates In 2003 And Presidential Election Results In 2004, F. Matthew Mihelic, David G. Schultz Jr., Melinda R. Mihelic

Faculty Publications

A statistical relationship exists between state per capita smallpox vaccination rates of healthcare workers in 2003 and state presidential election results in 2004. The potential implications of political influence on national biosecurity decision making are discussed.

Life, Health, And Disability Insurance: Understanding The Relationships, Robert H. Jerry Ii

Faculty Publications

This project focuses on the extent to which dis-ability insurers should be allowed to use genetic information in underwriting and rate-setting, but this subject cannot be completely isolated from the related questions of whether life and health insurers should also have this discretion. Federal and state laws place significant restrictions on insurers' use of genetic information in health insurance, but regulation of such use in life and disability insurance is considerably more modest. This essay examines the reasons for this disparity and discusses the implications for future proposals to regulate disability insurers' use of genetic information in underwriting and rate-set-ting. …

Weekend And Weekday Patterns Of Physical Activity In Overweight And Normal-Weight Adolescent Girls, Margarita S. Treuth, Diane J. Catellier, Kathryn H. Schmitz, Russell R. Pate, John P. Elder, Robert G. Mcmurray, Robert M. Blew, Song Yang, Larry S. Webber

Faculty Publications

Objective - To describe the patterns (specifically comparing weekdays and weekends classified by intensities) of physical activity (PA) measured by accelerometry in adolescent girls.

Research Methods and Procedures - Healthy sixth grade girls (n=1603), 11 to 12 years old, were randomly recruited from 36 schools participating in the Trial of Activity in Adolescent Girls. Age, ethnicity, socioeconomic status, weight, and height were taken. PA patterns were measured for 6 days using accelerometry.

Results - Adolescent girls spend most of their time in sedentary (52% to 57% of the day) and light activity (40% to 45% of the day) …

Perceived Individual, Social, And Environmental Factors For Physical Activity And Walking, Michelle L. Granner, Patricia A. Sharpe, Brent E. Hutto, Sarah Wilcox, Cheryl L. Addy

Faculty Publications

Background: Few studies have explored associations of individual, social, and environmental factors with physical and walking behavior. Methods: A random-digit-dial questionnaire, which included selected individual, social, and environmental variables, was administered to 2025 adults, age 18 y and older, in two adjacent counties in a southeastern state. Logistic regressions were conducted adjusting for age, race, sex, education, and employment. Results: In multivariate models, somewhat different variables were associated with physical activity versus regular walking. Self-efficacy (OR = 19.19), having an exercise partner (OR = 1.47), recreation facilities (OR = 1.54), and safety of trails from crime (OR = 0.72) were …

Dangers Of Deference To Form Arbitration Provisions, Amy J. Schmitz

Faculty Publications

This Article is part of my larger project exploring what I call "contracting culture," which borrows from legal realism and relational contract theory by considering contextual factors such as negotiators' relations, understandings, and values. As part of this project, I am pursuing various threads, including empirical studies of how contracting realities impact arbitration. In this Article, however, I focus on how these realities in business to consumer contracts combine with the Federal Arbitration Act and formulaic contract law to foster dangerous deference to form arbitration provisions. The Article then invites procedural reforms and offers suggestions for regulations aimed to temper …

Energizing An Invertebrate Embryo: Bafilomycin-Dependent Respiration And The Metabolic Cost Of Proton Pumping By The V-Atpase, Joseph A. Covi, Steven C. Hand

Faculty Publications

We examine herein the contribution of V-ATPase activity to the energy budget of aerobically developing embryos of Artemia franciscana and discuss the results in the context of quiescence under anoxia. 31P-NMR analysis indicates that intracellular pH and NTP levels are unaffected by acute incubation of dechorionated embryos with the V-ATPase inhibitor, bafilomycin A1. Bafilomycin A1 also has no significant effect on oxygen consumption by isolated mitochondria. Taken together, these data indicate that bafilomycin does not affect energy-producing pathways in the developing embryo. However, the V-ATPase inhibitor exhibits a concentration-dependent inhibition of oxygen consumption in aerobic embryos. A conservative analysis of …

In Search Of Polymorphic Alu Insertions With Restricted Geographic Distributions, Richard Cordaux, Deepa Srikanta, Jungnam Lee, Mark Stoneking, Mark A. Batzer

Faculty Publications

Alu elements are transposable elements that have reached over one million copies in the human genome. Some Alu elements inserted in the genome so recently that they are still polymorphic for insertion presence or absence in human populations. Recently, there has been an increasing interest in using Alu variation for studies of human population genetic structure and inference of individual geographic origin. Currently, this requires a high number of Alu loci. Here, we used a linker-mediated polymerase chain reaction method to preferentially identify low-frequency Alu elements in various human DNA samples with different geographic origins. The candidate Alu loci were …

Sines, Evolution And Genome Structure In The Opossum, Wanjun Gu, David A. Ray, Jerilyn A. Walker, Erin W. Barnes, Andrew J. Gentles, Paul B. Samollow, Jerzy Jurka, Mark A. Batzer, David D. Pollock

Faculty Publications

Short INterspersed Elements (SINEs) are non-autonomous retrotransposons, usually between 100 and 500 base pairs (bp) in length, which are ubiquitous components of eukaryotic genomes. Their activity, distribution, and evolution can be highly informative on genomic structure and evolutionary processes. To determine recent activity, we amplified more than one hundred SINE1 loci in a panel of 43 M. domestica individuals derived from five diverse geographic locations. The SINE1 family has expanded recently enough that many loci were polymorphic, and the SINE1 insertion-based genetic distances among populations reflected geographic distance. Genome-wide comparisons of SINE1 densities and GC content revealed that high SINE1 …

Genomic Organization And Imprinting Of The Peg3 Domain In Bovine, Joomyeong Kim, Anne Bergmann, Jung Ha Choo, Lisa Stubbs

Faculty Publications

Using multiple mammalian genomic sequences, we have analyzed the evolution and imprinting of several genes located in the Peg3 domain, including Mim1 (approved name, Mimt1), Usp29, Zim3, and Zfp264. A series of comparative analyses shows that the overall genomic structure of this 500-kb imprinted domain has been well maintained throughout mammalian evolution but that several lineage-specific changes have also occurred in each species. In the bovine domain, Usp29 has lost its protein-coding capability, Zim3 has been duplicated, and the expression of Zfp264 has become biallelic in brain and testis, which differs from paternal expression of mouse Zfp264 in brain. In …

Genome-Wide Association Scan Shows Genetic Variants In The Fto Gene Are Associated With Obesity-Related Traits, Angelo Scuteri, Serena Sanna, Wei Min Chen, Manuela Uda, Giuseppe Albai, James Strait, Samer Najjar, Ramaiah Nagaraja, Marco Orrú, Gianluca Usala, Mariano Dei, Sandra Lai, Andrea Maschio, Fabio Busonero, Antonella Mulas, Georg B. Ehret, Ashley A. Fink, Alan B. Weder, Richard S. Cooper, Pilar Galan, Aravinda Chakravarti, David Schlessinger, Antonio Cao, Edward Lakatta, Gonçalo R. Abecasis

Faculty Publications

The obesity epidemic is responsible for a substantial economic burden in developed countries and is a major risk factor for type 2 diabetes and cardiovascular disease. The disease is the result not only of several environmental risk factors, but also of genetic predisposition. To take advantage of recent advances in gene-mapping technology, we executed a genome-wide association scan to identify genetic variants associated with obesity-related quantitative traits in the genetically isolated population of Sardinia. Initial analysis suggested that several SNPs in the FTO and PFKP genes were associated with increased BMI, hip circumference, and weight. Within the FTO gene, rs9930506 …

Evolutionary Dynamics Of Transposable Elements In The Short-Tailed Opossum Monodelphis Domestica, Andrew J. Gentles, Matthew J. Wakefield, Oleksiy Kohany, Wanjun Gu, Mark A. Batzer, David D. Pollock, Jerzy Jurka

Faculty Publications

The genome of the gray short-tailed opossum Monodelphis domestica is notable for its large size (∼3.6 Gb). We characterized nearly 500 families of interspersed repeats from the Monodelphis. They cover ∼52% of the genome, higher than in any other amniotic lineage studied to date, and may account for the unusually large genome size. In comparison to other mammals, Monodelphis is significantly rich in non-LTR retrotransposons from the LINE-1, CR1, and RTE families, with <29% of the genome sequence comprised of copies of these elements. Monodelphis has at least four families of RTE, and we report support for horizontal transfer of this non-LTR retrotransposon. In addition to short interspersed elements (SINEs) mobilized by L1, we found several families of SINEs that appear to use RTE elements for mobilization. In contrast to L1-mobilized SINEs, the RTE-mobilized SINEs in Monodelphis appear to shift from G+C-rich to G+C-low regions with time. Endogenous retroviruses have colonized ∼10% of the opossum genome. We found that their density is enhanced in centromeric and/or telomeric regions of most Monodelphis chromosomes. We identified 83 new families of ancient repeats that are highly conserved across amniotic lineages, including 14 LINE-derived repeats; and a novel SINE element, MER131, that may have been exapted as a highly conserved functional noncoding RNA, and whose emergence dates back to ∼300 million years ago. Many of these conserved repeats are also present in human, and are highly over-represented in predicted cis-regulatory modules. Seventy-six of the 83 families are present in chicken in addition to mammals. ©2007 by Cold Spring Harbor Laboratory Press.

The Decline Of The American Superpower, Earl H. Fry

Faculty Publications

By 2040, the United States will no longer be considered as a global superpower and the world may be headed toward a long era devoid of any superpowers. This will occur as a result of several negative trends within the United States itself, combined with changing dynamics and exigencies in the global system and the rise of more powerful competitors in Asia and Europe. The negative trends within the United States include unprecedented governmental and international debt, dysfunctional campaign-finance and lobbying systems, unmanageable entitlement and health-care obligations, a deteriorating public education network, an inordinate concentration of wealth and power in …

Neighborhood Context And Ethnicity Differences In Body Mass Index: A Multilevel Analysis Using The Nhanes Iii (1988-1994), D. Phuong Do, Tamara Dubowitz, Chloe E. Bird, Nicole Lurie, José J. Escarce, Brian K. Finch

Faculty Publications

A growing body of literature has documented a link between neighborhood context and health outcomes. However, little is known about the relationship between neighborhood context and body mass index (BMI) or whether the association between neighborhood context and BMI differs by ethnicity. This paper investigates several neighborhood characteristics as potential explanatory factors for the variation of BMI across the United States; further, this paper explores to what extent segregation and the concentration of disadvantage across neighborhoods help explain ethnic disparities in BMI. Using data geo-coded at the census tract-level and linked with individual-level data from the Third National Health and …

Disparities In Mental Health Utilization Among Persons With Chronic Diseases, Saundra H. Glover, Keith T. Elder, Sudha Xirasagar, Jong-Deuk Baek, Crystal N. Piper, Dayna Campbell

Faculty Publications

This study used Aday and Andersen's Behavioral Model of Health Services Use to examine to role of chronic disease and the joint impact of race and chronic disease type on mental health utilization. Using data from Community Tracking Survey Household Survey, we tested the assumption that chronic disease, chronic disease type, and race are related to lower rates of mental health visits when adjusted for predisposing, enabling, and need factors. After adjusting for population characteristics, we found that race significantly moderated the impact of chronic disease type on mental health utilization, showing that African Americans with cardiovascular disease were half …

Federalism And The Tug Of War Within: Seeking Checks And Balance In The Interjurisdictional Gray Area, Erin Ryan

Faculty Publications

Federalism and the Tug of War Within explores tensions that arise among the underlying values of federalism when state or federal actors regulate within the "interjurisdictional gray area" that implicates both local and national concerns. Drawing examples from the failed response to Hurricane Katrina and other interjurisdictional problems to illustrate this conflict, the Article demonstrates how the trajectory set by the New Federalism's "strict-separationist" model of dual sovereignty inhibits effective governance in these contexts. In addition to the anti-tyranny, pro-accountability, and localism-protective values of federalism, the Article identifies a problem-solving value inherent in the capacity requirement of American federalism's subsidiarity …

Can We Make The Constitution More Democratic?, Ilya Somin, Neal Devins

Faculty Publications

No abstract provided.

International Courts And Tribunals, Lee M. Caplan, Nancy Amoury Combs, Carl Magnus Nesser, Ucheora O. Onwuamaegbu, Cesare P.R. Romano

Faculty Publications

This article summarizes significant developments in 2006 concerning international courts and tribunals, particularly events relating to the International Court of Justice, the Permanent Court of Arbitration, the Iran-U.S. Claims Tribunal, the Eritrea-Ethiopia Claims Commission, and arbitral tribunals constituted under the Convention on the Settlement of Investment Disputes Between States and Nationals of Other States. This article covers the period of activity from December 1, 2005, to November 30, 2006.

A Cultural Models Approach To Service Recovery, Glenn L. Christensen, Gaby Odekerken-Schröder, Torsten Ringberg

Faculty Publications

Service recovery research remains conflicted in its understanding of consumers’ recovery expectations and of why similar goods or service failures may lead to different recovery expectations. The authors argue that this conflict results from the assumption that consumer recovery expectations are monolithic and largely homogeneous, driven mainly by behavioral, relational, or contextual stimuli. Instead, recovery scenarios involving high-involvement (i.e., self-relevant) goods and service failures may activate closely held, identity-related cultural models that, though ultimately applied to regain balance (a foundational schema), differ according to their sociocultural heritage and create a range of unique consumer recovery preferences. The authors empirically identify …

Mentors And Students Seeking Knowledge, Meredith Jones-Gray

Faculty Publications

No abstract provided.

Putting Emotional Reactivity In Its Place? Exploring Family-Of-Origin Influences On Emotional Reactivity, Conflict, And Satisfaction In Premarital Couples, Brandt C. Gardner, Dean M. Busby, Andrew S. Brimhall

Faculty Publications

The purpose of this research was to develop a structural equation model that tested the effects of emotional reactivity on the relational health of a representative sample of 736 premarital couples. We hypothesized that partners’ perceived family-of-origin experience would be predictive of partners’ reports of their own and their partners’ emotional reactivity. These reports were hypothesized to predict partners’ reports of their own and their partners’ ability to manage conflict, which were hypothesized to predict relationship satisfaction. Overall, the model fit the data quite well, with particularly interesting differences by gender. We discuss the model’s fit within the larger body …