Digital Commons Network^™

Understanding The Epidemiology Of Malaria In Zanzibar Through Molecular And Serological Analysis Of Samples Collected During Reactive Case Detection, Vanrun Goel, Wahida Hassan, Caroline Murphy, Barbara B. Choloi, Mohamed Ali, Shija J. Shija, Jeffrey A. Bailey, Anders Björkman, Billey E. Ngasala, Eric Rogier, Jonathan J. Juliano, Jessica T. Lin

Faculty Publications

Background

The Zanzibar archipelago has been a pre-elimination region for malaria thanks to rigorous control interventions, but recent surges in malaria cases have been observed. The contribution of non-falciparum species to the current malaria situation is unknown.

Method

This study investigates the epidemiology of falciparum and non-falciparum malaria species in Zanzibar. Leveraging plasma extracted from dried blood spots (DBS) collected during reactive case detection (RCD) activities across Unguja island from May 2022 to January 2023, we measured immunoglobulin G (IgG) responses to Plasmodium MSP1-19kD antigens using a multiplex bead-based immunoassay. Additionally, active infections were detected using species-specific real-time PCR.

Results …

Cost-Effectiveness Of Pregabalin, Duloxetine, And Milnacipran Vs Amitriptyline For Moderate To Severe Fibromyalgia, Sarah S. Downen, Hussein M. Farag, Abby Davis, Chijioke M. Okeke, Kenechukwu C. Ben-Umeh, Ismaeel Yunusa Ph.D., Tewodros Eguale

Faculty Publications

Importance

Fibromyalgia (FM) is a chronic pain condition associated with substantial quality-of-life impairments and economic burden. Although multiple pharmacologic options are recommended in clinical guidelines, the relative cost-effectiveness of off-label amitriptyline compared with FDA-approved treatments remains poorly defined due to a scarcity of direct economic comparisons and the use of heterogenous outcome measures in the extant literature.

Objective

To evaluate the cost-effectiveness of pregabalin, duloxetine, and milnacipran compared with amitriptyline in adults with moderate to severe FM.

Design, Setting, and Participants

Decision analytical model using a Markov cohort state transition model to estimate lifetime costs and quality-adjusted life-years (QALYs) for …

Construction Project Performance Research: A Bibliometric, Scientometric, And Qualitative Review (1989–2023), Abdelnaser Abdelhameed, Mohamed S. Yamany, Ahmed Abdelaty, Emad Elbeltagi

Faculty Publications

Despite the significant increase in publications on construction project performance (CPP), there is a deficiency of research that rigorously assesses and synthesizes previous studies to delineate the field’s development, themes, and research gaps. This article employs quantitative and qualitative methodologies to critically evaluate studies on CPP published over the last three decades and indexed in the Scopus database. The quantitative approach includes bibliometric searches and scientometric analyses to assess the extent of research interest and achievements. The qualitative methodology aims to conduct thorough content analysis to classify existing material based on prevalent themes. The results demonstrate an exponential growth of …

Boronate Esters For The Binding And Detection Of Low Molecular Weight Volatile Amines, Xiaoning Li, James Boyt, Steven Sloope, Luke T. Lackovic, Mark D. Smith, James J. Lavingne

Faculty Publications

Conjugated thiophene-based diboronate esters, 1–4, were synthesized to investigate how substituents on catechol alter the Lewis acidity and accessibility to boron, and influence binding interactions with low molecular weight Lewis basic amines. Crystallographic analysis indicated that both boron centres bind analyte and that Lewis base coordination induces deplanarization of the conjugated system. Spectroscopic studies demonstrate that amine binding disrupts conjugation, producing distinct and reproducible optical responses that depend on analyte basicity and structure, with association constants in organic solvent ranging from 10³ to 10⁶ M⁻¹. Quantitative binding analyses indicate strong negative cooperativity between the two boron …

Nanomedicine Meets Immunotherapy: Transforming Chimeric Antigen Receptor T Cell Treatment For Solid Tumors, Stephen O'Rourke, Nuo Xu, Hongjun Wang, Hexin Chen

Faculty Publications

The emergence of effective immunotherapies has drastically revolutionized clinical management of many cancer types. Among them, chimeric antigen receptor (CAR)-T cell therapy (CTT), as a groundbreaking approach, has been considered as a “living drug,” displaying unprecedented clinical outcomes with hematological malignancies, including B cell leukemia and lymphomas, and multiple myeloma. Despite the high remission rates and improved survival achieved with hematological cancers, the effectiveness of CTT in solid tumors remains largely unsatisfactory. The efficacy of CTT in solid tumors is significantly challenged by multiple factors, including tumor-antigen heterogeneity, limited T cell trafficking and infiltration, a highly immunosuppressive tumor microenvironment, and …

The Promise Of Mindfulness-Based Interventions: A Stress-Reduction Strategy For Testicular Cancer Survivors' Health-Related Quality Of Life, Michael J. Rovito, Colin F. Mahony, Kamalie Thomas, Keith Brazendale, Ciaran Fairman Ph.D., Cscs, Cet

Faculty Publications

Background: Testicular cancer (TC) disproportionately affects younger men and carries unique psychosocial and physiological consequences that extend well beyond treatment. Despite favorable survival rates, TC survivors frequently report diminished health-related quality of life (HRQoL). These burdens are often compounded by masculinity-related identity disruptions, fear of recurrence, sexual dysfunction, and a lack of tailored psychosocial support. Existing interventions remain limited, with most programs focused on physical rehabilitation or early detection. Few address the multidimensional stressors that shape the TC survivorship experience.

Aims: This narrative review examines the literature on HRQoL among TC survivors and evaluates the potential of mindfulness-based interventions (MBIs) …

Association Of Body Fatness With Hypertension, Dyslipidemia, And Myocardial Infarction In A Multinational Pooled Cohort, Vivek Kumar Prasad, Chibueze Ogbonnaya, Hannah Oh, Andrew Atkin, Madison Kindred, Min-Jeong Shin, Dahyun Park, Jin Eui Kim, Mike Loosemore, Vartika Saxena, Ryan Porter, Courtney Kipps, Jason Jaggers, Xuemei Sui M.D., M.P.H., Ph.D., Carl J. Lavie, Mark Hamer

Faculty Publications

Objective

Methods

Results

Impact Of Iron-Bearing Fillers On The Mechanical Strength And Chemical Stability Of Magnesium Potassium Phosphate Matrices Incorporating Rhenium, Sergey Sayenko, Volodymyr Shkuropatenko, Hans Conrad Zur Loye, Petr Vecernik, Monika Kiselova, Vlastislav Kašpar, Vlastimil Miller, Petr Bezdicka, Jan Šubrt, Petra Ecorchard, Natalija Murafa, Iva Milisavljevic, Scott T. Misture

Faculty Publications

We report on the study of the immobilization process of non-radioactive rhenium (Re), a chemical analogue of technetium-99 (⁹⁹Tc), in compounds based on magnesium potassium phosphate (MKP), as well as the possibility of enhancing their properties with iron-bearing additives/fillers. Powdered Re2O7 was used as the initial Re-containing source. Because of the solubility and high leachability of Tc (VII), which is also volatile at high temperatures, its immobilization for long-term storage and disposal poses a serious challenge to researchers. Taking this into account, low-temperature stabilization technology based on MKP, a cementitious material, is currently considered promising. We prepared experimental …

Influence Of Superhydrophobic Surface Microstructure On Transient Jet Impingement Cooling, D. Jacob Butterfield, Brian D. Iverson, Daniel Maynes, Julie Crockett

Faculty Publications

Water jet impingement is an effective method of rapidly cooling a surface, but heat transfer from the surface is highly dependent on the surface condition and properties. Here, the impact of a superhydrophobic (SH) surface on heat transfer to an impinging, axisymmetric, room-temperature water jet with Re=6 x 10³to 18 x 103 is explored. SH surfaces are created by etching thin silicon wafers to form different micropatterns (posts or holes). Surfaces are heated to between 200 and 320°C, and the local surface temperature is measured with a thermal camera. The time resolved heat transfer from the surface and …

Rapid Flood Inundation Mapping For Dam Failure And Operations, Shivakumar Balachandran, Parvaneh Nikrou, Ayman Mokhtar Nemnem, Reza Saleh Alipour, Sagy Cohen, Xingong Li, Erfan Goharian, Jasim Imran

Faculty Publications

Dam failure often causes catastrophic flooding. Although conventional hydrodynamic models are available for generating flood inundation maps, there is a need for low-complexity models that can provide rapid inundation estimates during emergency situations. Operational releases of large volumes may also lead to downstream flooding. This study utilizes two DEM-based models, OWP HAND-FIM and FLDPLN, to produce flood inundation maps for near-real-time operational applications. Three dam-related scenarios, including failures and controlled operations, are examined using these simplified models for the Fall River Dam in Kansas. Breach flows are estimated using empirical relationships, and discharge attenuation is calculated using an analytical approach. …

Is History Precedent?, Allison Orr Larsen

Faculty Publications

It has been just over three years since the Supreme Court instructed lower courts to evaluate Second Amendment challenges by examining history and tradition. And it is no secret that the courts have struggled. This Article tackles a phenomenon that is born of that struggle. Overwhelmed by the task of evaluating historical claims, lower courts instead are turning to other judges as authorities on history. They are using what I call in this Article “historical precedents”—meaning language about history from an older decision that the subsequent judge then treats as authority, not as part of a legal rule but for …

Research Journal 2026: People And Places, José A. Rivera Ph.D

Faculty Publications

José Rivera narrates his life history from adolescence into college years, university teaching, research career, publications, and ends with post-retirement service as a giving back to community. For most of his term as an academic, his research focus was on community-based organizations that he terms “peoples’ institutions”: acequia associations and mutual help societies. For data, he conducted field work in New Mexico and the American Southwest as well as internationally, primarily in Mexico, Peru, Spain and the Philippines. While at these locations, he interviewed people, collected maps, researched archives, and took photographs as ethnographic evidence of people and places. His …

Ceo Pay Differences Between Us And Non-Us Firms: A New Longitudinal Investigation, Ruiyuan (Ryan) Chen, Sadok El Ghoul, Omrane Guedhami, Feiyu Liu

Faculty Publications

Research Question/Issue

Public and academic debates typically portray US CEOs as exceptionally well paid. Yet, evidence on the existence and magnitude of a US CEO pay premium is mixed and dated. This study uses an expanded, longitudinal dataset to identify whether such a pay premium exists and explores potential differences across countries, time, and governance and institutional contexts.

Research Findings/Insights

Using a dataset of over 42,000 firm-year observations from 34 countries during 2001–2018, we document a persistent but heterogeneous US CEO pay premium. Compared with non-US peers, US CEOs receive 23% more total pay and 20% more equity-based compensation, on …

Patient-Specific Lumped-Parameter Model For Quantifying Vessel-Specific Remodeling And Predicting Right Ventricular Function In Pulmonary Hypertension, Christopher G. Lechuga, Amirreza Kachabi, Mitchel J. Colebank, Claudia E. Korcarz, Farhan Raza

Faculty Publications

Purpose: Pulmonary hypertension (PH) is a heterogeneous disease with patient-specific variability and vessel-specific remodeling, which eventually lead to right ventricular (RV) failure. The gold standard for RV assessment—pressure–volume (PV) loop acquisition—is invasive and limited to specialized settings. This study aims to develop a patient-specific lumped-parameter model that quantifies vessel-specific remodeling and simulates RV PV loops across PH phenotypes using routine clinical data.

Methods: A lumped-parameter model was calibrated using right heart catheterization and echocardiography data. Model agreement was assessed by R2 values for pressure and flow goodness-of-fit, and model-derived hemodynamic metrics were comparedwith clinical values. A dimensionality reduction approach was …

Characterization Of Ru(Ii) Polypyridyl Photosensitizers Bound To Tio2 Supports Through A New Covalent Metal-Ester Bonding Motif, D. M. S. C. Dissanayake, Christopher T. Lebarron, Laura C. Maybach, Joseph J. Kuchta Iii, Seyyedamirhossein Hosseini, Aaron K. Vannucci

Faculty Publications

The development of photoelectrochemical (PEC) devices involves the attachment of molecular photosensitizers onto solid supports. Particularly significant to this work are PECs that rely on ruthenium-based photosensitizers on high band gap metal oxide (MOx) supports. In this study, we have explored a new ester binding motif (MOx-ester) to covalently attach a ruthenium polypyridyl photosensitizer to TiO₂. This new MOx-ester photoanode is compared to the traditional photoanodes that utilize acid/base binding groups to attach the molecular Ru sensitizers to TiO₂. The new MOx-ester binding motif is characterized by cyclic voltammetry UV-Vis, solid state ¹³C NMR, and …

Psychological Resilience In The Covid-19 Response: A Systematic Review For Future Public Health Preparedness, Atena Pasha, Abdul-Hanan Saani Inusah, Jannatun Nayem, Xiaoming Li, Shan Qiao

Faculty Publications

Objective: The COVID-19 pandemic has highlighted the importance of psychological resilience for well-being. While several reviews have addressed resilience in specific populations or contexts, few have synthesized global literature across diverse populations. This review examines psychological resilience across diverse populations, focusing on measurement, associated factors, and future public health preparedness strategies. Method: Guided by the PRISMA, a thorough search of PsycINFO, PubMed, ScienceDirect, and Web of Science was conducted in February 2024, including quantitative studies considering psychological resilience during the COVID-19 pandemic published in peer-reviewed English journals from 2020 to 2024, using search terms relevant to psychological resilience and COVID-19. …

Green Runs: Colorado Cannabis Sales During Ski Season, Joshua H. Hess, Isabellle Bassock

Faculty Publications

This study examines the impact of ski tourism on Colorado’s retail marijuana (RMJ) sales, leveraging county-level sales data and ski resort characteristics. Using a two-way fixed effects model, we analyze seasonal variations in RMJ sales across counties with differing ski resort acreages. Our findings indicate that ski resort counties experience significant increases in RMJ sales during peak ski months (December–March), with the most prominent effects observed in counties with the largest ski resorts. The largest ski resort county– Summit County– sees an estimated seasonal increase of $4.35 million in RMJ sales. We estimate the isolated extra-state ski tourism effects and …

“When And Where [We] Enter…”? Intersectional Ideologies And Experiences In African American Support For Lgbtq+ Communities, Monique L. Lyle, Todd Shaw

Faculty Publications

This article examines how intersectional ideologies and experiences of marginalization affect the extent to which African Americans support or oppose the marginalization of LGBTQ communities. We posit that awareness of the race-gender positionality of African American women, as well as the unique positionalities of other marginalized African American subgroups, is critical to understanding the conditions under which Black Americans embrace LGBTQ rights and communities. Using the Black respondent subsample of the 2016 Collaborative Multiracial Post-Election Study, we test the extent to which intersectional theories explain African American cross-group consciousness with LGBTQ persons and support for LGBTQ rights and communities. In …

Community Synchrony In Aquatic Macroinvertebrates Is Unrelated To Environmental Variability But Differs Among Functional Feeding Groups, Anthony J. Pignatelli, Tad Dallas

Faculty Publications

Environments are becoming increasingly more variable, as a function of climate change. As this occurs, species may be exposed to conditions outside their preferred range. Such variability in the environment can influence community abundance as individual species respond either similarly (synchronous dynamics) or differently (asynchronous dynamics) to each other. These fluctuations in abundances are important for understanding the impact of environmental variability on species temporal fluctuations in aquatic macroinvertebrates. This group of organisms is species-rich and highly sensitive to environmental fluctuations. We analyzed 18 stream macroinvertebrate communities sampled by the National Ecological Observatory Network between 2014 and2022 to understand how …

Effects Of Leucine Supplementation On Athletic Performance, Central Fatigue, And Serum Metabolism In Endurance Athletes: A Randomized Controlled Trial And Targeted Metabolomics Study, Tieying Li, Wei Xu, Jun Chen, Zhaobo Kan, Xuemei Sui, Zhiguang Zhao, Qirong Wang

Faculty Publications

Objectives: We aimed to investigate the effects of 6 weeks of leucine supplementation on athletic performance, central fatigue, and serum metabolome in endurance athletes, and to provide valuable insights into nutritional strategies for endurance athletes. Methods: Twenty cross-country skiers were recruited and randomized into 2 groups: the placebo (PLA) group and the leucine (LEU) group. Subjects were given leucine (8.5 g) + sucrose (14 g) or only sucrose (14 g) supplements twice each day from Monday to Saturday for 6 weeks. Test parameters include body composition, aerobic capacity, isokinetic muscle strength, blood biochemistry, and targeted metabolomics. Results: After intervention, compared …

Virtual And Remote Cardiac Rehabilitation For Older Adults: Current Evidence And Implementation Strategies, Sarah E. Slone, Rita D'Aoust, Rhonda Smith Wright, Victoria A. Yandle, Kurt G. Barringhaus

Faculty Publications

Purpose of Review

To present and analyze recent developments in remote cardiac rehabilitation for older adults, review outcomes data regarding clinical effectiveness of these modalities, and discuss implementation strategies targeted at older adults.

Recent Findings

Data from recent studies enrolling older adults into remote cardiac rehabilitation programs have yielded mixed results with some showing encouraging improvements in functional capacity and quality of life comparable to those obtained with center-based rehabilitation programs. Studies that showed no improvement in outcomes identified decreased patient engagement as an important driver of results. This underscores the importance of adapting remote cardiac rehabilitation programs to the …

Recalibrating The Risk Of False Confession Wrongful Convictions: Interrogation Tactics And Inverse Probability, Scott M. Mourtgos, Ian T. Adams

Faculty Publications

False confession wrongful convictions (FCWCs) are a serious failure of the criminal justice system. Although scholars have identified interrogation tactics thought to elevate this risk, existing research rarely estimates the population-level probability that legally permissible methods will produce an FCWC. Instead, inference relies on outcome-selected case series and laboratory diagnosticity ratios that ignore base rates and the far larger universe of interrogations without false confessions. This article offers a methodological recalibration. We formalize the outcome-selection problem and apply inverse probability logic to derive posterior FCWC risk integrating base rates, sensitivity, and specificity. Using Monte Carlo simulation, we synthesize available empirical …

Boiling A Frog: Pre-Adaptive Processes And Prison Riot Dynamics, Hayden P. Smith

Faculty Publications

This study explores the adaptive mechanisms and survival strategies deployed by incarcerated individuals during the Lee Prison Riot of April 15, 2018. Drawing solely on in-depth interviews with 25 incarcerated men (predominantly Black, aged 25–61) at Lee Correctional Institution, and utilizing the importation and deprivation models as analytical frameworks, the analysis reveals that early-life trauma, neighborhood disruption, and the construction of survival pride significantly shape inmate adaptation. In particular, the research documents how inmates are channeled into “high‑alpha dorms” where collective violence becomes both predictable and deeply ambiguous, and where post‑riot behaviors signal the emergence of a “new normal” in …

Improving Lexicosemantic Impairments In Post-Stroke Aphasia Using Rtms Targeting The Right Anterior Temporal Lobe, Sophie Arheix-Parras, Sophia R. Moore, Rutvik H. Desai

Faculty Publications

Background/Objectives: Repetitive Transcranial Magnetic Stimulation (rTMS) can enhance post-stroke aphasia recovery. The right Inferior Frontal Gyrus is the most common target in rTMS studies for inhibitory stimulation. However, lexicosemantic processes involve a large brain network including the Anterior Temporal Lobe (ATL). We hypothesize that rTMS targeting the ATL will improve lexicosemantic impairments in people with post-stroke aphasia. Methods: In a Single-Case Experimental Design, three people with post-stroke aphasia with lexicosemantic impairments performed Picture and Auditory Naming and Semantic Decision tasks five times a week for one or two weeks to establish baseline scores. Then, each participant received continuous inhibitory Theta …

Meet Me At The Rock: The Behavioral Patterns Of Collective Violence In Prison, Hayden P. Smith

Faculty Publications

This study explores the behavioral dynamics of collective violence in prisons, focusing on the largest prison riot in the United States in twenty-five years at Lee Correctional Institution, using an ethnographic approach and Crime Script Analysis (CSA). The sample consisted of twenty-five incarcerated men, predominantly African American, aged 25 to 61, with extensive incarceration histories, experiences of violence, and influencer status within the prison community. It identifies key factors such as situational awareness, gang affiliations, and chronic understaffing that escalate violence. Themes include the "pressure cooker" environment, elevated tensions, and stages of confrontation, escalation, and de-escalation. A key finding is …

Police Staffing Shortages, Public Awareness, And Policy Preferences, Hunter M. Boehme, Joshua Mccrain, Scott M. Mourtgos, Brandon Tregle

Faculty Publications

Since the summer of 2020, police agencies across the United States have continued to experience police staffing shortages. The consequences of understaffed police agencies are well studied, but little is known about whether the public is aware of the staffing problem and its consequences for public safety and police behavior. This study presents a pre-registered factorial survey experiment to 3105 US adults, varying the information respondents see on the consequences of staffing shortages (e.g., public safety, police behavior) and the messenger of this information (e.g., police chief, mayor). Respondents are then asked about their levels of concern about police staffing, …

When Disasters Trigger Cyber Vulnerabilities: Mapping Physical-Digital Interdependencies In Critical Infrastructure Systems, Dikshya Panta, Sicheng Wang, Aditya Sapkota, Prakash Ranganathan

Faculty Publications

Critical infrastructure (CI) systems such as power, water, communications, and emergency services are increasingly exposed to compound risks in which natural disasters and cyber incidents interact and amplify one another. Traditional risk assessments often isolate physical and digital threats, overlooking the cascading dependencies that emerge when operational stress, emergency reconfiguration, and adversarial exploitation coincide. This study conducts a 2019–2025 scoping review and introduces a Geographic Information System (GIS) driven six-stage disaster cyber compounding framework that characterizes, maps, and operationalizes compound risk across interdependent CI sectors. The framework integrates a common operating picture, analytic situational understanding, exposure mapping, threat-fingerprint encoding, detection …

The Age And Composition Of The Voyager Seamounts: Evidence For A Long-Lived Marquesas Mantle Source, Andrea Balbas, Hannah Paradis, Kevin Konrad, Valerie A. Finlayson, Michael Bizimis, Stephanie Anderson, Christopher Kelley, Nicole A. Raineault, Beth N. Orcutt

Faculty Publications

We present new observations on the dynamics and locations of deep mantle reservoirs derived from the ages and compositions of Voyager Seamount Chain lava flows. The previously unexplored Voyager Seamount Chain trends NW–SE between the Mid-Pacific Mountains and the Northwestern Hawaiian Ridge. Volcanic samples were recovered from the chain during the Ocean Exploration Trust expedition NA134. The lava flows are alkalic to highly alkalic in composition. Ages ranged from 81 to 86 Ma (n = 8), with the oldest ages in the NW and an age-progression toward the SE. The Voyager age-progression continues southward through the Northern Line Islands …

High Frobenius Pushforwards Generate The Bounded Derived Category, Matthew R. Ballard, Srikanth B. Iyengar, Pat Lank, Alapan Mukhopadhyay, Josh Pollitz

Faculty Publications

This work concerns generators for the bounded derived category of coherent sheaves over a noetherian scheme X of prime characteristic. The main result is that when the Frobenius map on X is finite, for any compact generator G of D(X) the Frobenius pushforward F^e_*G generates the bounded derived category whenever p^e is larger than the codepth of X, an invariant that is a measure of the singularity of X. The conclusion holds for all positive integers e when X is locally complete intersection. The question of when one can take G = …

Dietary Inflammatory Index And Risk Of Colorectal Cancer In Japanese Men, Ayaka Kotemori, Kumiko Kito, Motoki Iwasaki, Taiki Yamaji, James Hébert Scd, Junko Ishihara, Manami Inoue, Shoichiro Tsugane, Norie Sawada On The Behalf Of Jphc Study Group

Faculty Publications

Background/Objectives: Unhealthy lifestyles lead to chronic low-grade inflammation, increasing the risk of colorectal cancer. Few studies in East Asia have examined the association between the dietary inflammation potential and colorectal cancer incidence. Therefore, we aimed to investigate this association further in the Japanese population. Methods: This study included 38,807 men aged 45–74 years who participated in the Japan Public Health Center-based prospective study (JPHC Study). The energy-adjusted dietary inflammatory index (E-DII) was derived from a food frequency questionnaire. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using Cox proportional hazards regression models. Differences in risk due to a …