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Articles 541 - 570 of 16781
Full-Text Articles in Entire DC Network
Progerin Can Induce Dna Damage In The Absence Of Global Changes In Replication Or Cell Proliferation, Liza A. Joudeh, P. Logan Schuck, Nina M. Van, Alannah J. Dicintio, Jason A. Stewart, Alan S. Waldman
Progerin Can Induce Dna Damage In The Absence Of Global Changes In Replication Or Cell Proliferation, Liza A. Joudeh, P. Logan Schuck, Nina M. Van, Alannah J. Dicintio, Jason A. Stewart, Alan S. Waldman
Faculty Publications
Hutchinson-Gilford Progeria Syndrome (HGPS) is a rare genetic condition characterized by features of accelerated aging, and individuals with HGPS seldom live beyond their mid-teens. The syndrome is commonly caused by a point mutation in the LMNA gene which codes for lamin A and its splice variant lamin C, components of the nuclear lamina. The mutation causing HGPS leads to production of a truncated, farnesylated form of lamin A referred to as "progerin." Progerin is also expressed at low levels in healthy individuals and appears to play a role in normal aging. HGPS is associated with an accumulation of genomic DNA …
Everyone Brings Something To The Table: A Culturally Sustaining Analysis Of Teacher Candidates’ Mixed Reality Teaching Simulations, Erin Scott
Faculty Publications
Discussions of HBCU students’ content knowledge have centered around developing high impact, asset-based approaches to learning (Williams et al, 2022). So, HBCU teacher preparation providers (TPPs) can also focus efforts on culturally sustaining approaches to developing candidates’ content knowledge and researching how high impact practices, like teaching simulations, can help prepare candidates for classrooms. This exploratory case study uses critical cases (n=2); findings suggest candidates have a developing understanding of content, which forms a solid basis for increasing their knowledge. MRTSs are addressed as a potential high impact, culturally sustaining practice for building candidates’ content knowledge. Further, HBCU TPPs can …
Carbon Dioxide Fluxes And The Dominant Role Of Vegetation In Recently Created And Reference Gulf Coast Marshes, A. Muench, T. Elsey-Quirk, J. R. White, R. D. Delaune
Carbon Dioxide Fluxes And The Dominant Role Of Vegetation In Recently Created And Reference Gulf Coast Marshes, A. Muench, T. Elsey-Quirk, J. R. White, R. D. Delaune
Faculty Publications
Coastal wetlands are one of the most productive ecosystems on Earth with the capacity to sequester large amounts of carbon dioxide (CO2). Wetland loss due to anthropogenic and natural causes reduces the carbon (C) storage capacity and potentially releases previously fixed C in biomass and soil to the water column and atmosphere through decomposition. Coastal wetland restoration has the potential to mitigate some of the C losses depending on the balance of C fluxes. However, the role of vegetation and environmental conditions in governing rates of C accumulation in restoration sites is not well resolved. The purpose of this study …
Net Evaporation-Induced Mangrove Area Loss Across Low-Lying Caribbean Islands, Isamar M. Cortés, Jorge Lorenzo-Trueba, Andre S. Rovai, Robert R. Twilley, Mark Chopping, Temilola Fatoyinbo
Net Evaporation-Induced Mangrove Area Loss Across Low-Lying Caribbean Islands, Isamar M. Cortés, Jorge Lorenzo-Trueba, Andre S. Rovai, Robert R. Twilley, Mark Chopping, Temilola Fatoyinbo
Faculty Publications
Although mangroves provide many beneficial ecosystem services, such as blue carbon storage and coastal protection, they are currently under threat due to changes in climate conditions, such as prolonged drought exposure. Under drought conditions, evaporation exceeds precipitation and high soil salinities can lead to stunted growth and die-back. To quantify this interplay, we developed a database for low-lying and uninhabited mangrove islands in the Caribbean under various evaporation and precipitation regimes. We extracted physical and biological information from each island using remote sensing techniques and coupled it with a process-based model. We used this database to develop a model that …
A Temperature Tipping Point In Hypoxic Zone Size, R. Eugene Turner, Nancy N. Rabalais, Cassandra N. Glaspie
A Temperature Tipping Point In Hypoxic Zone Size, R. Eugene Turner, Nancy N. Rabalais, Cassandra N. Glaspie
Faculty Publications
Temperature increases will have ubiquitous effects on aquatic food webs, from microbes to consumers, and affect the quality and quantity of carbon flows within and between water layers. A decline in the biological pump moving carbon from surface to lower layers is anticipated. We reviewed 37 years of data on hypoxic zone size and water quality in the northern Gulf of Mexico to determine if air and bottom water temperature increases (0.5°C decade−1) are significantly related to variations in its areal size. There was no significant decline in important river water quality in the 24 years since the …
Detecting, Attributing, And Projecting Global Marine Ecosystem And Fisheries Change: Fishmip 2.0, Julia L. Blanchard, Camilla Novaglio, Olivier Maury, Cheryl S. Harrison, Colleen M. Petrik, Denisse Fierro-Arcos, Kelly Ortega-Cisneros, Andrea Bryndum-Buchholz, Tyler D. Eddy, Ryan Heneghan, Kelsey Roberts, Jacob Schewe, Daniele Bianchi, Jerome Guiet, P. Daniel Van Denderen, Juliano Palacios-Abrantes, Xiao Liu, Charles A. Stock, Yannick Rousseau, Matthias Büchner, Ezekiel O. Adekoya, Cathy Bulman, William Cheung, Villy Christensen, Marta Coll, Leonardo Capitani, Samik Datta, Elizabeth A. Fulton, Alba Fuster, Victoria Garza, Matthieu Lengaigne, Max Lindmark, Kieran Murphy
Detecting, Attributing, And Projecting Global Marine Ecosystem And Fisheries Change: Fishmip 2.0, Julia L. Blanchard, Camilla Novaglio, Olivier Maury, Cheryl S. Harrison, Colleen M. Petrik, Denisse Fierro-Arcos, Kelly Ortega-Cisneros, Andrea Bryndum-Buchholz, Tyler D. Eddy, Ryan Heneghan, Kelsey Roberts, Jacob Schewe, Daniele Bianchi, Jerome Guiet, P. Daniel Van Denderen, Juliano Palacios-Abrantes, Xiao Liu, Charles A. Stock, Yannick Rousseau, Matthias Büchner, Ezekiel O. Adekoya, Cathy Bulman, William Cheung, Villy Christensen, Marta Coll, Leonardo Capitani, Samik Datta, Elizabeth A. Fulton, Alba Fuster, Victoria Garza, Matthieu Lengaigne, Max Lindmark, Kieran Murphy
Faculty Publications
There is an urgent need for models that can robustly detect past and project future ecosystem changes and risks to the services that they provide to people. The Fisheries and Marine Ecosystem Model Intercomparison Project (FishMIP) was established to develop model ensembles for projecting long-term impacts of climate change on fisheries and marine ecosystems while informing policy at spatio-temporal scales relevant to the Inter-Sectoral Impact Model Intercomparison Project (ISIMIP) framework. While contributing FishMIP models have improved over time, large uncertainties in projections remain, particularly in coastal and shelf seas where most of the world's fisheries occur. Furthermore, previous FishMIP climate …
Food At Sea On The Late Antique Mediterranean, Andrew Donnelly, Justin Leidwanger
Food At Sea On The Late Antique Mediterranean, Andrew Donnelly, Justin Leidwanger
Faculty Publications
No abstract provided.
Trajectories Of Offending Over 9 Years After Youths' First Arrest: What Predicts Who Desists And Who Continues To Offend?, Elizabeth Cauffman, Jordan Beardslee, Colleen Sbeglia, Paul J. Frick, Laurence Steinberg
Trajectories Of Offending Over 9 Years After Youths' First Arrest: What Predicts Who Desists And Who Continues To Offend?, Elizabeth Cauffman, Jordan Beardslee, Colleen Sbeglia, Paul J. Frick, Laurence Steinberg
Faculty Publications
Antisocial and illegal behavior generally declines as youth approach adulthood, but there is significant individual variation in the timing of the peak and decline of offending from adolescence to young adulthood. There are two primary research questions in the present study. First, are there subgroups of youth who follow similar patterns of offending over the nine years after their first arrest? Second, what baseline factors predict which youth will follow each pattern of offending? Data were drawn from the Crossroads study, which includes a sample of racially and ethnically diverse boys who were interviewed regularly for 9 years following their …
Evidence For A Shock-Compressed Magnetic Field In The Northwestern Rim Of Vela Jr. From X-Ray Polarimetry, Dmitry A. Prokhorov, Yi Jung Yang, Riccardo Ferrazzoli, Jacco Vink, Patrick Slane, Enrico Costa, Stefano Silvestri, Ping Zhou, Niccolò Bucciantini, Alessandro Di Marco, Martin C. Weisskopf, Luca Baldini, Victor Doroshenko, Steven R. Ehlert, Jeremy Heyl, Philip Kaaret, Dawoon E. Kim, Frédéric Marin, Tsunefumi Mizuno, Chi Yung Ng, Melissa Pesce-Rollins, Carmelo Sgrò, Paolo Soffitta, Douglas A. Swartz, Toru Tamagawa, Fei Xie, Iván Agudo, Lucio A. Antonelli, Matteo Bachetti, Wayne H. Baumgartner, Ronaldo Bellazzini, Stefano Bianchi, Stephen D. Bongiorno
Evidence For A Shock-Compressed Magnetic Field In The Northwestern Rim Of Vela Jr. From X-Ray Polarimetry, Dmitry A. Prokhorov, Yi Jung Yang, Riccardo Ferrazzoli, Jacco Vink, Patrick Slane, Enrico Costa, Stefano Silvestri, Ping Zhou, Niccolò Bucciantini, Alessandro Di Marco, Martin C. Weisskopf, Luca Baldini, Victor Doroshenko, Steven R. Ehlert, Jeremy Heyl, Philip Kaaret, Dawoon E. Kim, Frédéric Marin, Tsunefumi Mizuno, Chi Yung Ng, Melissa Pesce-Rollins, Carmelo Sgrò, Paolo Soffitta, Douglas A. Swartz, Toru Tamagawa, Fei Xie, Iván Agudo, Lucio A. Antonelli, Matteo Bachetti, Wayne H. Baumgartner, Ronaldo Bellazzini, Stefano Bianchi, Stephen D. Bongiorno
Faculty Publications
Synchrotron X-ray emission has been detected from nearly a dozen young supernova remnants (SNRs). X-rays of synchrotron origin exhibit linear polarization in a regular, non-randomly oriented magnetic field. The significant polarized X-ray emission from four such SNRs has already been reported on the basis of observations with the Imaging X-ray Polarimetry Explorer (IXPE). The magnetic-field structure as derived from IXPE observations is radial for Cassiopeia A, Tycho's SNR, and SN 1006, and tangential for RX J1713.7-3946. The latter together with the recent detection of a tangential magnetic field in SNR 1E 0102.2-7219 by the Australia Telescope Compact Array in the …
Identification And Expression Analysis Of Phosphate Transporter 1 (Pht1) Genes In The Highly Phosphorus-Use-Efficient Hakea Prostrata (Proteaceae), Benjamin J. Nestor, Toby Bird, Anita A. Severn-Ellis, Philipp E. Bayer, Kosala Ranathunge, M. Asaduzzaman Prodhan, Maheshi Dassanayake, Jacqueline Batley, David Edwards, Hans Lambers, Patrick M. Finnegan
Identification And Expression Analysis Of Phosphate Transporter 1 (Pht1) Genes In The Highly Phosphorus-Use-Efficient Hakea Prostrata (Proteaceae), Benjamin J. Nestor, Toby Bird, Anita A. Severn-Ellis, Philipp E. Bayer, Kosala Ranathunge, M. Asaduzzaman Prodhan, Maheshi Dassanayake, Jacqueline Batley, David Edwards, Hans Lambers, Patrick M. Finnegan
Faculty Publications
Heavy and costly use of phosphorus (P) fertiliser is often needed to achieve high crop yields, but only a small amount of applied P fertiliser is available to most crop plants. Hakea prostrata (Proteaceae) is endemic to the P-impoverished landscape of southwest Australia and has several P-saving traits. We identified 16 members of the Phosphate Transporter 1 (PHT1) gene family (HpPHT1;1-HpPHT1;12d) in a long-read genome assembly of H. prostrata. Based on phylogenetics, sequence structure and expression patterns, we classified HpPHT1;1 as potentially involved in Pi uptake from soil and HpPHT1;8 and HpPHT1;9 as potentially involved in Pi uptake and root-to-shoot …
Management Strategies For Preventing And Recovering From Bermudagrass Winterkill, W. J. Hutchens, T. Q. Carr, A. J. Patton, C. A. Bigelow, E. J. Deboer, J. M. Goatley, D. L. Martin, D. S. Mccall, G. L. Miller, J. S. Powlen, M. D. Richardson, M. Xiang
Management Strategies For Preventing And Recovering From Bermudagrass Winterkill, W. J. Hutchens, T. Q. Carr, A. J. Patton, C. A. Bigelow, E. J. Deboer, J. M. Goatley, D. L. Martin, D. S. Mccall, G. L. Miller, J. S. Powlen, M. D. Richardson, M. Xiang
Faculty Publications
Bermudagrass (Cynodon spp. Rich) is a warm-season grass that is widely planted throughout tropical, sub-tropical, and even temperate climates, and it generally requires fewer inputs than most cool-season turfgrasses. In recent years, the area of adaptation for bermudagrass has progressively expanded to cooler climates due to the development of more cold-tolerant cultivars. The expanded area of adaptation as well as the reduced inputs required to maintain healthy turfgrass have made bermudagrass a popular choice in areas of marginal adaptation. In these areas, the greatest threat to bermudagrass health and survivability is winterkill. This management guide seeks to describe winterkill: what …
Substituent Effects On The Photophysical Properties Of A Series Of 8(Meso)-Pyridyl-Bodipys: A Computational Analysis Of The Experimental Data †, Petia Bobadova-Parvanova, Dylan Goliber, Elijuah Hernandez, Daniel Lamaster, Maria Da Graça H. Vicente
Substituent Effects On The Photophysical Properties Of A Series Of 8(Meso)-Pyridyl-Bodipys: A Computational Analysis Of The Experimental Data †, Petia Bobadova-Parvanova, Dylan Goliber, Elijuah Hernandez, Daniel Lamaster, Maria Da Graça H. Vicente
Faculty Publications
Recently, a series of 8(meso)-pyridyl-BODIPYs (2-pyridyl, 3-pyridyl, and 4-pyridyl) and their 2,6-substituted derivatives were synthesized and their structure and photophysical properties were studied both experimentally and computationally. One of the main observed trends was that the 2-pyridyl-BODIPYs were consistently less fluorescent than their 3-pyridyl and 4-pyridyl analogs, regardless of the 2,6-substituents. Herein, we extend our previous computational studies and model not only the ground but also the excited states of the entire series of previously synthesized meso-pyridyl-BODIPYs with the aim of explaining the observed differences in the emission quantum yields. To better understand the trends and the effect of 2- …
Cgbi_Yolo: Lightweight Land Target Detection Network, Ruiyang Wang, Siyu Lu, Jiawei Tian, Lirong Yin, Lei Wang, Xiaobing Chen, Wenfeng Zheng
Cgbi_Yolo: Lightweight Land Target Detection Network, Ruiyang Wang, Siyu Lu, Jiawei Tian, Lirong Yin, Lei Wang, Xiaobing Chen, Wenfeng Zheng
Faculty Publications
Object detection algorithms for optical remote sensing images often face challenges in computational efficiency, particularly when detecting small and densely packed targets. This paper introduces CGBi_YOLO, a novel lightweight land target detection network designed to optimize computational resource utilization while maintaining detection capabilities for small-scale targets. Our approach incorporates an innovative lightweight optimization strategy featuring a new lightweight backbone feature extraction network: CSPGhostNet. This model significantly enhances the detection ability of small objects within optical remote sensing images without increasing computational demands. The efficacy of the proposed model is validated through rigorous experimentation on the DOTA dataset. Compared to the …
Research Overview On Urban Heat Islands Driven By Computational Intelligence, Chao Liu, Siyu Lu, Jiawei Tian, Lirong Yin, Lei Wang, Wenfeng Zheng
Research Overview On Urban Heat Islands Driven By Computational Intelligence, Chao Liu, Siyu Lu, Jiawei Tian, Lirong Yin, Lei Wang, Wenfeng Zheng
Faculty Publications
In recent years, the intensification of the urban heat island (UHI) effect has become a significant concern as urbanization accelerates. This survey comprehensively explores the current status of surface UHI research, emphasizing the role of land use and land cover changes (LULC) in urban environments. We conducted a systematic review of 8260 journal articles from the Web of Science database, employing bibliometric analysis and keyword co-occurrence analysis using CiteSpace to identify research hotspots and trends. Our investigation reveals that vegetation cover and land use types are the two most critical factors influencing UHI intensity. We analyze various computational intelligence techniques, …
Preserving The Future Of Juries And Jury Trials, Paula Hannaford-Agor, Hope Forbush, Miriam Hamilton, Jawwaad Johnson, Morgan Moffett
Preserving The Future Of Juries And Jury Trials, Paula Hannaford-Agor, Hope Forbush, Miriam Hamilton, Jawwaad Johnson, Morgan Moffett
Faculty Publications
To preserve the future of juries and jury trials, the National Center for State Courts (NCSC) convened a meeting of representatives from a broad array of justice system stakeholders as a project under the Justice for All Reauthorization Act (JFARA). To frame the stakeholder discussions, NCSC employed strategic foresight, a methodological approach designed to explore a range of possible futures of juries and jury trials within the American justice system as a vehicle for identifying critical vulnerabilities within the current jury system and proposing targeted strategies to preserve and strengthen jury trials. Critical vulnerabilities are those areas of weakness that …
The Relationship Between A Transient Scientific Phenomenon And Local Journalism At The Beginning Of The Gilded Age, Thomas Hockey
The Relationship Between A Transient Scientific Phenomenon And Local Journalism At The Beginning Of The Gilded Age, Thomas Hockey
Faculty Publications
In the United States, the nineteenth century was the halcyon era for local newspapers. These publications were the primary source of public information at a time when other periodicals and books had low circulation. The purpose of this paper is to explore how local journalism in the nineteenth-century United States dealt with an occasion outside the boundaries of the commonplace: an unfamiliar natural phenomenon. My example is the total solar eclipse of 7 August 1869. Editors and journalists of the time largely were unaccustomed to covering celestial events. Nevertheless, they sensed—correctly—an interest in the solar eclipse. Articles about the approaching …
The Pagan Reception Of Judaism From The Sibylline Oracles: Insights From Pseudo-Seneca’S Octavia Regarding The Creation And Circulation Of Oral Sibylline Oracles By The Plebs, Kenneth Atkinson
Faculty Publications
According to tradition, the original collection of Sibylline Books acquired by the Roman monarch Tarquinius Priscus, which were kept in the Temple of Jupiter in the capital, were lost in the fire of 83 BCE. In 76 BCE, the Senate ordered the college of the quindecimviri to travel to the traditional centers of Sibylline activity in the East to find Sibylline Oracles to replace those destroyed in the fire. According to Lactantius, these officials collected many Oracles from private individuals. This reference suggests that Sibylline Oracles circulated widely. However, based on the witnesses regarding their consultation, it appears that the …
An Account Of The 1453 Ce Ottoman Siege Of Constantinople Interpreted Through A First Century Bce Jewish Text: How An Ancient Collection Of Second Temple Period Poems Changed The Course Of Western Civilization, Kenneth Atkinson
Faculty Publications
On 29 May 1453 CE, the besieged Christian occupants of Constantinople — the capital of the Byzantine Empire and the last surviving portion of the former Roman Empire — knew the end was near when they heard 50,000-80,000 angry Ottoman soldiers, including 5,000 to 10,000 of the elite Janissaries — the Sultan’s shook troops — preparing to breach its walls after a 53-day siege. The 7,000-man army defending the city knew that all was lost. The 21-year-old Sultan Mehmet II — given the sobriquet “the Conqueror” for capturing the city — leveled the roads so his army could reach Constantinople’s …
Law And Equity On Appeal, Aaron-Andrew P. Bruhl
Law And Equity On Appeal, Aaron-Andrew P. Bruhl
Faculty Publications
Most lawyers know that the Federal Rules of Civil Procedure merged the divergent trial procedures of the common law and of equity, but fewer are familiar with the development of federal appellate procedure. Here too there is a story of the merger of two distinct systems. At common law, a reviewing court examined the record for errors of law after the final trial judgment. In the equity tradition, an appeal was a rehearing of the law and the facts that aimed at achieving justice and did not need to await a final judgment. Unlike the story of federal trial procedure, …
Roman History In Sibylline Oracle 13: A Palestinian Jewish Perspective On Emperors, Usurpers, And Saviors During The Third Century Ce (Part Two: From Decius To Odenath Of Palmyra), Kenneth Atkinson
Faculty Publications
Sibylline Oracle 13 is a remarkable historical document that contains a unique perspective on the poorly documented period of Roman history known as the “Crisis of the Third Century (235-284 CE), which began with the assassination of the Roman emperor Severus Alexander (222-235 CE), the last ruler of the Severan dynasty. This turbulent era was marked by nearly fifty years of civil wars, barbarian invasions, rebellions, and approximately twenty-six claimants to the throne. Although the end of this turmoil under Diocletian (284-305 CE) is well known, we have little information about much of this century, particularly its first decades. The …
Cryo-Em Structure Of A Photosystem I Variant Containing An Unusual Plastoquinone Derivative In Its Electron Transfer Chain, Christopher J. Gisriel, Vasily Kurashov, David F. Iwig, Brandon P. Russell, David J. Vinyard, Gary W. Brudvig, John H. Golbeck, K. V. Lakshmi
Cryo-Em Structure Of A Photosystem I Variant Containing An Unusual Plastoquinone Derivative In Its Electron Transfer Chain, Christopher J. Gisriel, Vasily Kurashov, David F. Iwig, Brandon P. Russell, David J. Vinyard, Gary W. Brudvig, John H. Golbeck, K. V. Lakshmi
Faculty Publications
Photosystem I (PS I) is a light-driven oxidoreductase responsible for converting photons into chemical bond energy. Its application for renewable energy was revolutionized by the creation of the MenB deletion (ΔmenB) variant in the cyanobacterium Synechocystis sp. PCC 6803, in which phylloquinone is replaced by plastoquinone-9 with a low binding affinity. This permits its exchange with exogenous quinones covalently coupled to dihydrogen catalysts that bind with high affinity, thereby converting PS I into a stable solar fuel catalyst. Here, we reveal the 2.03-Å-resolution cryo-EM structure of a recent MenB variant of PS I. The quinones and their binding environment are …
Impact Of Vaporization On Drop Aerobreakup, B. Boyd, S. Becker, Yue Stanley Ling
Impact Of Vaporization On Drop Aerobreakup, B. Boyd, S. Becker, Yue Stanley Ling
Faculty Publications
Aerodynamic breakup of vaporizing drops is commonly seen in many spray applications. While it is well known that vaporization can modulate interfacial instabilities, the impact of vaporization on drop aerobreakup is poorly understood. Detailed interface-resolved simulations were performed to systematically study the effect of vaporization, characterized by the Stefan number, on the drop breakup and acceleration for different Weber numbers and density ratios. It is observed that the resulting asymmetric vaporization rates and strengths of Stefan flow on the windward and leeward sides of the drop hinder bag development and prevent drop breakup. The critical Weber number thus generally increases …
Bound States And Particle Production By Breather-Type Background Field Configurations, Abhishek Rout, Brett Altschul
Bound States And Particle Production By Breather-Type Background Field Configurations, Abhishek Rout, Brett Altschul
Faculty Publications
We investigate the interaction of fermion fields with oscillating domain walls, inspired by breather-type solutions of the sine-Gordon equation, a nonlinear system of fundamental importance. Our study focuses on the fermionic bound states and particle production induced by a time-dependent scalar background field. The fermions couple to two domain walls undergoing harmonic motion, and we explore the resulting dynamics of the fermionic wave functions. We demonstrate that while fermions initially form bound states around the domain walls, the energy provided by the oscillatory motion of the scalar field induces an outward flux of fermions and antifermions, leading to particle production …
Applying Machine‐Learning Methods To Laser Acceleration Of Protons: Lessons Learned From Synthetic Data, Ronak Desai, Thomas Zhang, J. J. Felice, Ricky Oropeza, Joseph R. Smith, Alona Kryshchenko, Chris Orban, Michael L. Dexter, Anil K. Patnaik
Applying Machine‐Learning Methods To Laser Acceleration Of Protons: Lessons Learned From Synthetic Data, Ronak Desai, Thomas Zhang, J. J. Felice, Ricky Oropeza, Joseph R. Smith, Alona Kryshchenko, Chris Orban, Michael L. Dexter, Anil K. Patnaik
Faculty Publications
In this study, we consider three different machine-learning methods—a three-hidden-layer neural network, support vector regression, and Gaussian process regression—and compare how well they can learn from a synthetic data set for proton acceleration in the Target Normal Sheath Acceleration regime. The synthetic data set was generated from a previously published theoretical model by Fuchs et al. 2005 that we modified. Once trained, these machine-learning methods can assist with efforts to maximize the peak proton energy, or with the more general problem of configuring the laser system to produce a proton energy spectrum with desired characteristics. In our study, we focus …
Motivational Dysregulation With Melanocortin 4 Receptor Haploinsufficiency, Alex M. Steiner, Robert F. Roscoe, Rosemarie M. Booze, Charles F. Mactutus
Motivational Dysregulation With Melanocortin 4 Receptor Haploinsufficiency, Alex M. Steiner, Robert F. Roscoe, Rosemarie M. Booze, Charles F. Mactutus
Faculty Publications
Obesity, by any standard, is a global health crisis. Both genetic and dietary contributions to the development and maintenance of obesity were integral factors of our experimental design. As mutations of the melanocortin 4 receptors (MC4R) are the leading monogenetic cause of obesity, MC4R haploinsufficient rats were fed a range of dietary fat (0–12 %) in a longitudinal design. Physiological and motivational assessments were performed using a locomotor task, a 5-choice sucrose preference task, an operant task with fixed and progressive ratios, as well as a distraction operant task. Dendritic spine morphology of medium spiny neurons (MSNs) of the nucleus …
Mediator Kinase Inhibitors Suppress Triple-Negative Breast Cancer Growth And Extend Tumor Suppression By Mtor And Akt Inhibitors, Xiaokai Ding, Jiaxin Liang, Amanda C. Sharko, Thomas A. Hilimire, Jing Li, Jürgen Loskutov, Zachary T. Mack, Hao Ji, Gary P. Schools, Chao Cai, Elena N. Pugacheva, Mengqian Chen, Igor Roninson, Eugenia Broude
Mediator Kinase Inhibitors Suppress Triple-Negative Breast Cancer Growth And Extend Tumor Suppression By Mtor And Akt Inhibitors, Xiaokai Ding, Jiaxin Liang, Amanda C. Sharko, Thomas A. Hilimire, Jing Li, Jürgen Loskutov, Zachary T. Mack, Hao Ji, Gary P. Schools, Chao Cai, Elena N. Pugacheva, Mengqian Chen, Igor Roninson, Eugenia Broude
Faculty Publications
Triple-negative breast cancers (TNBC) are treated primarily by chemotherapy and lack clinically validated therapeutic targets. In particular, inhibitors of the PI3K/AKT/mTOR pathway, abnormally activated in many breast cancers, failed to achieve clinical efficacy in TNBC due to the development of adaptive drug resistance, which is largely driven by the transcriptomic plasticity of TNBC. Expression of CDK8/19 Mediator kinases that control transcriptional reprogramming correlates with relapse-free survival and treatment failure in breast cancer patients, including TNBC. We now investigated how CDK8/19 inhibitors affect the growth of TNBC tumors and their response to mTOR and AKT inhibitors. In contrast to the effects …
Strategies To Alleviate Flickering: Bayesian And Smoothing Methods For Deep Learning Classification In Video, Noah Miller, Glen Ryan Drumm, Lance Champagne, Bruce A. Cox, Trevor Bihl
Strategies To Alleviate Flickering: Bayesian And Smoothing Methods For Deep Learning Classification In Video, Noah Miller, Glen Ryan Drumm, Lance Champagne, Bruce A. Cox, Trevor Bihl
Faculty Publications
Excerpt: Increasing reliance on autonomous systems requires confidence in the accuracies produced from computer vision classification algorithms. Computer vision (CV) for video classification provides phenomenal abilities, but it often suffers from “flickering” of results. Flickering occurs when the CV algorithm switches between declared classes over successive frames. Such behavior causes a loss of trust and confidence in their operations.
Limitations Of Beam-Control Compensation, Matthew Kalensky, Darren Getts, Matthias T. Banet, Derek J. Burrell, Milo W. Hyde, Mark F. Spencer
Limitations Of Beam-Control Compensation, Matthew Kalensky, Darren Getts, Matthias T. Banet, Derek J. Burrell, Milo W. Hyde, Mark F. Spencer
Faculty Publications
In this paper, we use wave-optics simulations to explore the limitations of beam-control compensation. We evaluate performance in terms of the normalized power in a diffraction-limited bucket for the cases of no beam-control compensation, perfect phase compensation, and perfect full-field compensation. From these results, we are able to arrive at the following conclusions: (1) without any form of beam-control compensation, performance begins to degrade when D/r0 > 1; (2) with perfect phase compensation, performance begins to degrade when D/r0 > 1 and (λ/r0)/θ0 > 1; and (3) with perfect full-field compensation, performance begins to degrade when D/r0 …
Ultra-Relativistic Electron Flux Enhancement Under Persistent High Speed Solar Wind Stream, L R. Alves, L A. Da Silva, V Deggeroni, J P. Marchezi, P R. Jauer, G B D Silva, D G. Sibeck
Ultra-Relativistic Electron Flux Enhancement Under Persistent High Speed Solar Wind Stream, L R. Alves, L A. Da Silva, V Deggeroni, J P. Marchezi, P R. Jauer, G B D Silva, D G. Sibeck
Faculty Publications
The physical mechanisms usually applied to explain the relativistic electron enhancement have been delved into to elucidate non-adiabatic electron acceleration resulting in the ultra-relativistic electron population observed in the outer radiation belt. We considered multisatellite observations of the solar wind parameters, magnetospheric waves, and particle flux to report an unusual local acceleration of ultra-relativistic electrons under a prolonged high-speed solar wind stream (HSS). A corotating interaction region reaches the Earth’s bowshock on August 3, 2016, causing a minor geomagnetic storm. Following this, the magnetosphere was driven for 72 h by a long-term HSS propagating at 600 km/s. During this period, …
Ultra-Relativistic Electron Flux Enhancement Under Persistent High Speed Solar Wind Stream, L R. Alves, L A. Da Silva, V Deggeroni, J P. Marchezi, P R. Jauer, G B D Silva, D G. Sibeck
Ultra-Relativistic Electron Flux Enhancement Under Persistent High Speed Solar Wind Stream, L R. Alves, L A. Da Silva, V Deggeroni, J P. Marchezi, P R. Jauer, G B D Silva, D G. Sibeck
Faculty Publications
The physical mechanisms usually applied to explain the relativistic electron enhancement have been delved into to elucidate non-adiabatic electron acceleration resulting in the ultra-relativistic electron population observed in the outer radiation belt. We considered multisatellite observations of the solar wind parameters, magnetospheric waves, and particle flux to report an unusual local acceleration of ultra-relativistic electrons under a prolonged high-speed solar wind stream (HSS). A corotating interaction region reaches the Earth’s bowshock on August 3, 2016, causing a minor geomagnetic storm. Following this, the magnetosphere was driven for 72 h by a long-term HSS propagating at 600 km/s. During this period, …