Digital Commons Network^™

A Saturated Map Of Common Genetic Variants Associated With Human Height, Loïc Yengo, Sailaja Vedantam, Eirini Marouli, Julia Sidorenko, Eric Bartell, Saori Sakaue, Marielisa Graff, Anders U. Eliasen, Yunxuan Jiang, Sridharan Raghavan, Jenkai Miao, Joshua D. Arias, Sarah E. Graham, Ronen E. Mukamel, Cassandra N. Spracklen, Xianyong Yin, Shyh Huei Chen, Teresa Ferreira, Heather H. Highland, Yingjie Ji, Tugce Karaderi, Kuang Lin, Kreete Lüll, Deborah E. Malden, Carolina Medina-Gomez, Moara Machado, Amy Moore, Sina Rüeger, Xueling Sim, Scott Vrieze, Tarunveer S. Ahluwalia, Masato Akiyama, Matthew A. Allison

Faculty Publications

Common single-nucleotide polymorphisms (SNPs) are predicted to collectively explain 40–50% of phenotypic variation in human height, but identifying the specific variants and associated regions requires huge sample sizes1. Here, using data from a genome-wide association study of 5.4 million individuals of diverse ancestries, we show that 12,111 independent SNPs that are significantly associated with height account for nearly all of the common SNP-based heritability. These SNPs are clustered within 7,209 non-overlapping genomic segments with a mean size of around 90 kb, covering about 21% of the genome. The density of independent associations varies across the genome and the regions of …

With Great Power Comes Great Responsibility: Superheroes & The Law, Thomas Simmons, Chris Dellicarpini, Rick Collins

Faculty Publications

Legal issues and lessons abound in superhero narratives. Caped heroes often act above and outside the law but deliver on law’s promises of justice and mercy in ways that ordinary legal actors cannot. Legal ethics, criminal law, and procedure are all on display. Superheroes supply a framework for examination of multiple legal issues and lessons, including what it means to be ethical (within the context of the rules of professional conduct and also in a broader sense) and how a legal life can be a virtuous one.

Beyond The Ångström Exponent: Probing Additional Information In Spectral Curvature And Variability Of In Situ Aerosol Hyperspectral (0.3–0.7 Μm) Optical Properties, Carolyn E. Jordan, Bruce E. Anderson, John D. Barrick, Dani Blum, Kathleen Brunke, Jiajue Chai, Gao Chen, Ewan C. Crosbie, Jack E. Dibb, Ann M. Dillner, Emily Gargulinski, Charles H. Hudgins, Emily Joyce, Jackson Kaspari, Robert F. Martin, Richard H. Moore, Rachel O’Brien, Claire E. Robinson, Gregory L. Schuster, Taylor J. Shingler, Michael A. Shook, Amber J. Soja, Kenneth L. Thornhill, Andrew T. Weakley, Elizabeth B. Wiggins, Edward L. Winstead, Luke D. Ziemba

Faculty Publications

Ångström exponents (α) allow reconstruction of aerosol optical spectra over a broad range of wavelengths from measurements at two or more wavelengths. Hyperspectral measurements of atmospheric aerosols provide opportunities to probe measured spectra for information inaccessible from only a few wavelengths. Four sets of hyperspectral in situ aerosol optical coefficients (aerosol-phase total extinction, σext, and absorption, σabs; liquid-phase soluble absorption from methanol, σMeOH-abs, and water, σDI-abs, extracts) were measured from biomass burning aerosols (BBAs). Hyperspectral single scattering albedo (ω), calculated from σext and σabs, provide spectral resolution over a wide spectral range rare for this optical parameter. Observed spectral shifts …

A Five-Country Study Of Front- And Back-Of-Package Nutrition Label Awareness And Use: Patterns And Correlates From The 2018 International Food Policy Study, Jasmin Bhawra, Sharon I. Kirkpatrick, Marissa G. Hall, Lana Vanderlee, Jim Thrasher Ph.D., Ma, Ms, Alejandra Jáuregui De La Mota, David Hammond

Faculty Publications

Objective:

This study aimed to identify correlates of nutrition label awareness and use, particularly subgroup differences among consumers. Two label types were assessed: (1) nutrition facts tables (NFt) in Australia, Canada, Mexico, UK, and USA and (2) front-of-package (FOP) labels, including mandatory Guideline Daily Amounts (Mexico), voluntary Health Star Ratings (Australia) and voluntary Traffic Lights (UK). Design:

Respondents were recruited using Nielsen Consumer Insights Global Panel (n 21 586) and completed online surveys in November–December 2018. Linear regression and generalised linear mixed models examined differences in label use and awareness between countries and label type based on sociodemographic, knowledge-related and …

In A Double-Bind: Time-Space Distanciation, Socioeconomic Status, And Coping With Financial Stress In The United States, Harrison J. Schmitt, Adeena L. Black, Lucas A. Keefer, Daniel Sullivan

Faculty Publications

Psychological research has shown that lower socioeconomic status (SES) individuals experience higher levels of stress and tend to cope in more present-oriented ways. While some research in the field has sought to, for instance, increase future-oriented ways of being among lower SES individuals, we argue that such approaches may come at significant cost. We consider the construct of time–space distanciation (TSD) – the normative way in which time and space are abstracted from one another at cultural and individual levels – as a way to complicate psychological research on social class, stress, and coping. Across four studies, we present research …

Friendship As The Primary Purpose Of Law, Michael P. Moreland

Faculty Publications

A significant aspect of the legacy of John Finnis is the restoration of friendship to a central place in moral, political, and legal theory building on the classical tradition in Plato, Aristotle, and Aquinas. This essay surveys the implications of friendship for law by way of exploring Finnis’s treatment of friendship in several of his works, including friendship as a condition for discourse, friendship as an especially important illustration of the central case, the relationship between friendship and the common good, and the place of civic friendship in a political community. The essay concludes with a discussion of friendship with …

Reconciling Copyright "Restoration" For Pre-1972 Foreign Sound Recordings With The Classics Protection And Access Act, Tyler T. Ochoa

Faculty Publications

When Congress first added sound recordings to the Copyright Act, it acted prospectively only: sound recordings fixed on or after February 15, 1972, received federal statutory copyright protection, while sound recordings fixed before February 15, 1972, were left to the vagaries of state law. This historic inequity was corrected in 2018 with enactment of the Classics Protection and Access Act (CPA), which provides sui generis protection to pre-1972 sound recordings that is similar, but not identical, to federal copyright protection. But there is a subset of pre-1972 sound recordings that already had federal copyright protection before the CPA was enacted: …

Associations Between Visceral Adipose Tissue Estimates Produced By Near-Infrared Spectroscopy, Mobile Anthropometrics, And Traditional Body Composition Assessments And Estimates Derived From Dual-Energy X-Ray Absorptiometry, Austin J. Graybeal, Caleb F. Brandner, Grant M. Tinsley, Hunter Haynes, Jon Stavres

Faculty Publications

Assessments of visceral adipose tissue (VAT) are critical in preventing metabolic disorders; however, there are limited measurement methods that are accurate and accessible for VAT. The purpose of this cross-sectional study was to evaluate the association between VAT estimates from consumer-grade devices and traditional anthropometrics and VAT and subcutaneous adipose tissue (SAT) from dual-energy X-ray absorptiometry (DXA). Data were collected from 182 participants (female = 114; White = 127; Black/African-American (BAA) = 48) which included anthropometrics and indices of VAT produced by near-infrared reactance spectroscopy (NIRS), visual body composition (VBC) and multifrequency BIA (MFBIA). VAT and SAT were collected using …

The Impact Of Meal Dietary Inflammatory Index On Exercise-Induced Changes In Airway Inflammation In Adults With Asthma, Katrina P. Mcdiarmid, Lisa G. Wood, John W. Upham, Lesley K. Macdonald-Wicks, Nitin Shivappa Mbbs, Mph, Ph.D., James R. Hébert Scd, Hayley A. Scott

Faculty Publications

Research suggests exercise may reduce eosinophilic airway inflammation in adults with asthma. The Dietary Inflammatory Index (DII®) quantifies the inflammatory potential of the diet and has been associated with asthma outcomes. This study aimed to determine whether the DII of a meal consumed either before or after exercise influences exercise-induced changes in airway inflammation. A total of 56 adults with asthma were randomised to (1) 30–45 min moderate–vigorous exercise, or (2) a control group. Participants consumed self-selected meals, two hours pre- and two hours post-intervention. Energy-adjusted DII (E-DIITM) was determined for each meal, with meals then characterised as “anti-inflammatory” or …

Bias In Measurement Of Autism Symptoms By Spoken Language Level And Non-Verbal Mental Age In Minimally Verbal Children With Neurodevelopmental Disorders (Vol 13, 927847, 2022), Shuting Zheng, Aaron Kaat, Cristan Farmer, Audrey Thurm, Catherine A. Burrows, Stephen Kanne, Stelios Georgiades, Amy Esler, Catherine Lord, Nicole Takashashi, Kerri P. Nowell, Elizabeth A. Will Ph.D., Bcba, Jane E. Roberts, Somer L. Bishop

Faculty Publications

No abstract provided.

Incorporating Diversity, Equity, And Inclusion Principles Into Our Metadata, Nicole Lewis, Allie Mccormack, Rachel Jane Wittmann

Faculty Publications

This presentation was given at the Core Forum 2022 in Salt Lake City, Utah.

In early 2021, a group of librarians at two university libraries embarked on a journey to review and update harmful subject headings and other metadata in their catalog, digital library, and finding aids. This session will discuss the background of the project and where the librarians currently stand in the process of remediating these records, including their efforts to create student internships to address problematic language in archival finding aids as well as create a community user advisory group. Special attention will be given to creating …

Development Of A Prediction Model For The Management Of Noncommunicable Diseases Among Older Syrian Refugees Amidst The Covid-19 Pandemic In Lebanon, Stephen J. Mccall, Tanya El Khoury, Noura Salibi, Berthe Abi Zeid, Maria El Haddad, Marwan F. Alawieh, Sawsan Abdulrahim, Monique Chaaya, Hala Ghattas Ph.D., Abla M. Sibai

Faculty Publications

Importance: Older Syrian refugees have a high burden of noncommunicable diseases (NCDs) and economic vulnerability.

Objectives: To develop and internally validate a predictive model to estimate inability to manage NCDs in older Syrian refugees, and to describe barriers to NCD medication adherence.

Design, Setting, and Participants: This nested prognostic cross-sectional study was conducted through telephone surveys between September 2020 and January 2021. All households in Lebanon with Syrian refugees aged 50 years or older and who received humanitarian assistance from a nongovernmental organization were invited to participate. Refugees who self-reported having chronic respiratory disease (CRD), diabetes, history of cardiovascular disease …

Tau Neutrinos In The Next Decade: From Gev To Eev, Roshan Mammen Abraham, Jamie Alvarez-Muñiz, Carlos A. Argüelles, Akitaka Ariga, Tomoko Ariga, Adam Aurisano, Dario Autiero, Mary Bishai, Nilay Bostan, Mauricio Bustamante, Austin Cummings, Valentin Decoene, André De Gouvêa, Giovanni De Lellis, Albert De Roeck, Peter B. Denton, Antonia Di Crescenzo, Milind V. Diwan, Yasaman Farzan, Anatoli Fedynitch, Jonathan L. Feng, Laura J. Fields, Alfonso Garcia, Maria Vittoria Garzelli, Julia Gehrlein, Christian Glaser, Katarzyna Grzelak, Steffen Hallmann, Jeremy Hewes, D Indumathi, Ahmed Ismail, Sudip Jana, Yu Seon Jeong, Kevin J. Kelly, Spencer R. Klein, Felix Kling, Thomas Kosc, Umut Kose, D Jason Koskinen, John Krizmanic, Jeff Lazar, Yichen Li, Ivan Martinez-Soler, Irina Mocioiu, Jiwoo Nam, Valentin Niess, Nepomuk Otte, Sameer Patel, Roberto Petti, Et. Al.

Faculty Publications

Tau neutrinos are the least studied particle in the standard model. This whitepaper discusses the current and expected upcoming status of tau neutrino physics with attention to the broad experimental and theoretical landscape spanning long-baseline, beam-dump, collider, and astrophysical experiments. This whitepaper was prepared as a part of the NuTau2021 Workshop.

Metabolome-Wide Associations Of Gestational Weight Gain In Pregnant Women With Overweight And Obesity, Jin Dai, Nansi S. Boghossian, Mark Sarzynski Ph.D., Faha, Facsm, Feng Luo, Xiaoqian Sun, Jian Li, Oliver Fiehn, Jihong Liu Sc.D., Liwei Chen

Faculty Publications

Excessive gestational weight gain (GWG) is associated with adverse pregnancy outcomes. This metabolome-wide association study aimed to identify metabolomic markers for GWG. This longitudinal study included 39 Black and White pregnant women with a prepregnancy body mass index (BMI) of ≥ 25 kg/m². Untargeted metabolomic profiling was performed using fasting plasma samples collected at baseline (mean: 12.1 weeks) and 32 weeks of gestation. The associations of metabolites at each time point and changes between the two time points with GWG were examined by linear and least absolute shrinkage and selection operator (LASSO) regression analyses. Pearson correlations between the …

Solvation Of Large Polycyclic Aromatic Hydrocarbons In Helium: Cationic And Anionic Hexabenzocoronene, Miriam Kappe, Florent Calvo, Johannes Schöntag, Holger F. Bettinger, Serge Krasnokutski, Martin Kuhn, Elisabeth Gruber, Fabio Zappa, Paul Scheier, Olof E. Echt

Faculty Publications

The adsorption of helium on charged hexabenzocoronene (Hbc, C₄₂H₁₈), a planar polycyclic aromatic hydrocarbon (PAH) molecule of D_6h symmetry, is investigated by a combination of high-resolution mass spectrometry and classical and quantum computational methods. The ion abundance of He_nHbc⁺ complexes versus size n features prominent local anomalies at n = 14, 38, 68, 82, and a weak one at 26, indicating that for these “magic” sizes the helium evaporation energies are relatively large. Surprisingly, mass spectra of anionic He_nHbc^– complexes feature a different set of anomalies, namely at …

Wave-Front Reconstruction Via Single-Pixel Homodyne Imaging, Savannah L. Cuozzo, Charris Gabaldon, Pratik J. Barge, Ziqi Niu, Hwang Lee, Lior Cohen, Irina Novikova, Eugeniy E. Mikhailov

Faculty Publications

We combine single-pixel imaging and homodyne detection to perform full object recovery (phase and amplitude). Our method does not require any prior information about the object or the illuminating fields. As a demonstration, we reconstruct the optical properties of several semi-transparent objects and find that the reconstructed complex transmission has a phase precision of 0.02 radians and a relative amplitude precision of 0.01.

The Exercise Metabolome: Acute Aerobic And Anaerobic Signatures, Joseph K. Pellegrino, Tracy G. Anthony, Peter Gillies, Shawn M. Arent

Faculty Publications

Background

Exercise modality differentially alters body composition and physical performance. Metabolic changes underlying these outcomes can be tracked through assessment of circulating metabolites. Here, global responses to an acute bout of aerobic or anaerobic exercise were compared in the serum of male and female subjects using a discovery-based metabolomics platform.

Methods

On separate days, 40 healthy, active participants completed 45 min of aerobic cycling or resistance exercise, and blood samples were collected at rest, immediately after (T1) and 1 hour post-exercise (T2) to examine the serum metabolomic landscape.

Results

The two exercise metabolomes appeared more similar than different in this …

Fashion Or Function: Examining Consumers' Perceived Values Of Mass-Customized Menswear Via A Content Mining Approach, Yuli Liang, Snigdha Rangineni, Chuanlan Liu

Faculty Publications

Mass customization has been used in various clothing products including T-shirts, dress shirts, jeans, sports shoes, accessories, etc. However, even though the concept of mass customization has been accepted among scholars and business practitioners, and the application of mass customization has been practiced in the fashion industry for more than two decades, the acceptance among ultimate consumers and the market of MC in the apparel industry has not taken off yet. To this end, this study intends to fill the identified gap through a content mining exploratory qualitative study using customer value theory to evaluate individual consumers' actual customization experiences. …

Utilizing Genomics And Historical Data To Optimize Gene Pools For New Breeding Programs: A Case Study In Winter Wheat, Carolina Ballén-Taborda, Jeanette Lyerly, Jared Smith, Kimberly Howell, Gina Brown-Guedira, Md Ali Babar, Stephen A. Harrison, Richard E. Mason, Mohamed Mergoum, J. Paul Murphy, Russell Sutton, Carl A. Griffey, Richard E. Boyles

Faculty Publications

With the rapid generation and preservation of both genomic and phenotypic information for many genotypes within crops and across locations, emerging breeding programs have a valuable opportunity to leverage these resources to 1) establish the most appropriate genetic foundation at program inception and 2) implement robust genomic prediction platforms that can effectively select future breeding lines. Integrating genomics-enabled1 breeding into cultivar development can save costs and allow resources to be reallocated towards advanced (i.e., later) stages of field evaluation, which can facilitate an increased number of testing locations and replicates within locations. In this context, a reestablished winter wheat breeding …

"The Rule” And The Constitution: Witness Exclusion And The Right To A Public Trial, Stephen E. Smith

Faculty Publications

Federal and state rules of evidence provide for the exclusion of potential witnesses from the courtroom. But, in criminal proceedings, the Sixth Amendment’s right to a public trial presumes that a courtroom will be open. The public trial right has been widely interpreted to restrict even “partial closures” – the exclusion of an individual or group from a criminal courtroom. The rule on witnesses is potentially at odds with the right to a public trial. Witness exclusion, by rule, is almost automatic. The Sixth Amendment, on the other hand, requires heightened scrutiny before individuals may be excluded from the courtroom. …

The Risk And Clinical Implications Of Antibiotic-Associated Acute Kidney Injury: A Review Of The Clinical Data For Agents With Signals From The Food And Drug Administration’S Adverse Event Reporting System (Faers) Database, Kalin M. Clifford, Ashley R. Selby, Kelly R. Reveles, Chengwen Teng, Ronald G. Hall Ii, Jamie Mccarrell, Carlos A. Alvarez

Faculty Publications

Antibiotic-associated acute kidney injury (AA-AKI) is quite common, especially among hospitalized patients; however, little is known about risk factors or mechanisms of why AA-AKI occurs. In this review, the authors have reviewed all available literature prior to 1 June 2022, with a large number of AKI reports. Information regarding risk factors of AA-AKI, mechanisms behind AA-AKI, and treatment/management principles to decrease AA-AKI risk were collected and reviewed. Patients treated in the inpatient setting are at increased risk of AA-AKI due to common risk factors: hypovolemia, concomitant use of other nephrotoxic medications, and exacerbation of comorbid conditions. Clinicians should attempt to …

A Survey Of Retail Trade Patterns In South Dakota: 2012-2021, Rand E. Wergin

Faculty Publications

This paper provides an analysis of retail sales and retail trade in the state of South Dakota for the years 2012 to 2021. This analysis will provide valuable information to community leaders in the cities and towns of South Dakota. Along with measures such as unemployment and inflation, Retail Pull (RP) provides a measure of community’s economic health. For example, retail is often the largest employer in a city, particularly the smaller communities of South Dakota, and a robust retail sector provides a tax base to support community services. Thus, the economic health of the community depends on the viability …

Impact Of Horizontal Resolution (Submesoscale Permitting Vs. Mesoscale Resolving) On Ocean Dynamic Features In The South China Sea, Renhao Wu, Liqun Jia, Chunyan Li, Yu Liu, Bo Han, Dake Chen

Faculty Publications

Model resolution is a key factor that impacts the model bias in simulating ocean dynamics. How would model resolution influence model bias is an important question. In this study, we set up two sets of experiments with identical settings except the grid resolution, one with a minimum spacing of 2 km, referred to as the submesoscale permitting (SP) model, and the other with a minimum spacing of 6 km, referred to as the mesoscale resolving (MR) model, to investigate the impact of horizontal resolution on simulated dynamic features in the South China Sea. Results show that the SP outperforms the …

Solving The Procedural Puzzles Of The Texas Heartbeat Act And Its Imitators: New York Times V. Sullivan As Historical Analogue, Charles W. "Rocky" Rhodes, Howard M. Wasserman

Faculty Publications

The Texas Heartbeat Act (S.B. 8) prohibits abortions following detection of a fetal heartbeat while delegating exclusive enforcement through private civil actions brought by “any person,” regardless of injury, for statutory damages of a minimum of $10,000 per prohibited abortion. Texas sought to impose costly litigation and potentially crippling liability on reproductive health providers and rights advocates, with the hope of stopping abortion in the state. Prior to Dobbs v. Jackson Women’s Health Organization overruling Roe v. Wade and eliminating constitutional protection for abortion, the law represented a unique threat to reproductive freedom. But states are spreading S.B. 8’s exclusive …

Dissemination Trial For Health For Hearts United: Model Development, Preliminary Outcomes And Lessons Learned, Penny A. Ralston, Iris Young-Clark, Kandauda Wickrama, Catherine Coccia, Jennifer L. Lemacks, Arrie M. Battle, Celeste Hart, Jasminka Z. Ilich

Faculty Publications

No abstract provided.

For Their Own Good: Girls, Sexuality, And State Violence In The Name Of Safety, Madalyn K. Wasilczuk

Faculty Publications

No abstract provided.

Taxation And The Constitution, Reconsidered, David Gamage, John R. Brooks

Faculty Publications

Our current income tax is unable to address growing concentrations of financial wealth and resulting economic inequality. But reforms to address these problems—such as a wealth tax or an income tax on unrealized capital gains—are stymied by fears of unconstitutionality. The basic claim is that wealth taxes and similar reforms are “direct taxes” under the Apportionment Clauses of the Constitution, and since apportionment is not feasible, these taxes are impossible. But this claim is wrong.

This Article shows that there is in fact a long history of federal taxes similar to wealth taxes—both apportioned and uniform—and a well-developed constitutional tax …

Permafrost And Climate Change: Carbon Cycle Feedbacks From The Warming Arctic, Edward A. G. Schuur, Benjamin W. Abbott, Roisin Commane, Jessica G. Ernakovich, Eugenie Euskirchen, Gustaf Hugelius, Guido Grosse, Miriam Jones, Charlie Koven, Victor Leshyk, David Lawrence, Michael M. Loranty, Marguerite Mauritz, David Olefeldt, Susan Natali, Heidi Rodenhizer, Verity Salmon, Christina Schadel, Jens Strauss, Claire C. Treat, Merritt Turetsky

Faculty Publications

Rapid Arctic environmental change affects the entire Earth system as thawing permafrost ecosystems release greenhouse gases to the atmosphere. Understanding how much permafrost carbon will be released, over what time frame, and what the relative emissions of carbon dioxide and methane will be is key for understanding the impact on global climate. In addition, the response of vegetation in a warming climate has the potential to offset at least some of the accelerating feedback to the climate from permafrost carbon. Temperature, organic carbon, and ground ice are key regulators for determining the impact of permafrost ecosystems on the global carbon …

Inheritance Of Resistance To Cry1a.105 In Helicoverpa Zea (Boddie) (Lepidoptera: Noctuidae), Wenbo Yu, Graham P. Head, Fangneng Huang

Faculty Publications

Cry1A.105 is a bioengineered Bacillus thuringiensis (Bt) insecticidal protein consisting of three domains derived from Cry1Ac, Cry1Ab, and Cry1F. It is one of the two pyramided Bt toxins expressed in the MON 89034 event, a commonly planted Bt maize trait in the Americas. Recent studies have documented that field resistance of the corn earworm, Helicoverpa zea (Boddie), to the Cry1A.105 toxin in maize plants has become widespread in the United States. To investigate the inheritance of resistance to Cry1A.105 in H. zea, two independent tests, each with various genetic crosses among susceptible and Cry1A.105-resistant populations, were performed. The responses of …

Observational Constraints On Anisotropies For Bouncing Alternatives To Inflation, Ivan Agullo, Javier Olmedo, Edward Wilson-Ewing

Faculty Publications

We calculate how primordial anisotropies in the background space-time affect the evolution of cosmological perturbations for bouncing alternatives to inflation, like ekpyrosis and the matter bounce scenario. We find that the leading order effect of anisotropies in the contracting phase of the universe is to induce anisotropies in the cosmic microwave background with a very concrete form: a scale-invariant quadrupolar angular distribution. Sub-leading effects are the generation of higher-order moments in the angular distribution, as well as cross-correlations between scalar and tensor modes. We also find that observational constraints from the cosmic microwave background on the quadrupole moment provide strong …