Digital Commons Network^™

Acoustofluidics For Simultaneous Nanoparticle-Based Drug Loading And Exosome Encapsulation, Zeyu Wang, Joseph Rich, Nanjing Hao, Yuyang Gu, Chuyi Chen, Shujie Yang, Peiran Zhang, Tony Jun Huang

Faculty Publications

Nanocarrier and exosome encapsulation has been found to significantly increase the efficacy of targeted drug delivery while also minimizing unwanted side effects. However, the development of exosome-encapsulated drug nanocarriers is limited by low drug loading efficiencies and/or complex, time-consuming drug loading processes. Herein, we have developed an acoustofluidic device that simultaneously performs both drug loading and exosome encapsulation. By synergistically leveraging the acoustic radiation force, acoustic microstreaming, and shear stresses in a rotating droplet, the concentration, and fusion of exosomes, drugs, and porous silica nanoparticles is achieved. The final product consists of drug-loaded silica nanocarriers that are encased within an …

To Stick Or Not To Stick: The Multiple Roles Of Cell Adhesion Molecules In Neural Circuit Assembly, Trevor Moreland, Fabienne E. Poulain

Faculty Publications

Precise wiring of neural circuits is essential for brain connectivity and function. During development, axons respond to diverse cues present in the extracellular matrix or at the surface of other cells to navigate to specific targets, where they establish precise connections with post-synaptic partners. Cell adhesion molecules (CAMs) represent a large group of structurally diverse proteins well known to mediate adhesion for neural circuit assembly. Through their adhesive properties, CAMs act as major regulators of axon navigation, fasciculation, and synapse formation. While the adhesive functions of CAMs have been known for decades, more recent studies have unraveled essential, non-adhesive functions …

High-Mobility Semiconducting Polymers With Different Spin Ground States, Xiao-Xiang Chen, Jia-Tong Li, Yu-Hui Fang, Xin-Yu Deng, Xue-Qing Wang, Guangchao Liu, Yunfei Wang, Xiaodan Gu, Shang-Da Jiang, Ting Lei

Faculty Publications

Organic semiconductors with high-spin ground states are fascinating because they could enable fundamental understanding on the spin-related phenomenon in light element and provide opportunities for organic magnetic and quantum materials. Although high-spin ground states have been observed in some quinoidal type small molecules or doped organic semiconductors, semiconducting polymers with high-spin at their neutral ground state are rarely reported. Here we report three high-mobility semiconducting polymers with different spin ground states. We show that polymer building blocks with small singlet-triplet energy gap (ΔE_S-T) could enable small ΔE_S-T gap and increase the diradical character in copolymers. …

A Case Study Of Protecting Bridges Against Overheight Vehicles, Aly Mousaad Aly, Marc Hoffmann

Faculty Publications

Most transportation departments have recognized and developed procedures to address the ever-increasing weights of trucks traveling on bridges in service today. Transportation agencies also recognize the issues with overheight vehicles’ collisions with bridges, but few stakeholders have definitive countermeasures. Bridges are becoming more vulnerable to collisions from overheight vehicles. The exact response under lateral impact force is difficult to predict. In this paper, nonlinear impact analysis shows that the degree of deformation recorded through the modeling of the unprotected vehicle-girder model provides realistic results compared to the observation from the US-61 bridge overheight vehicle impact. The predicted displacements are 0.229 …

Pickle Associates With Histone Deacetylase 9 To Mediate Vegetative Phase Change In Arabidopsis, Tieqiang Hu, Darren Manuela, Valerie Hinsch, Mingli Xu

Faculty Publications

• The juvenile-to-adult vegetative phase change in flowering plants is mediated by a decrease in miR156 levels. Downregulation of MIR156A/MIR156C, the two major sources of miR156, is accompanied by a decrease in acetylation of histone 3 lysine 27 (H3K27ac) and an increase in trimethylation of H3K27 (H3K27me3) at MIR156A/MIR156C in Arabidopsis.

• Here, we show that histone deacetylase 9 (HDA9) is recruited to MIR156A/MIR156C during the juvenile phase and associates with the CHD3 chromatin remodeler PICKLE (PKL) to erase H3K27ac at MIR156A/MIR156C.

• H2Aub and H3K27me3 become enriched at MIR156A/MIR156C, and the recruitment of Polycomb Repressive Complex …

Predictors Of Therapy Response In Chronic Aphasia: Building A Foundation For Personalized Aphasia Therapy, Sigfus Kristinsson, Dirk B. Den Ouden, Chris Rorden, Roger Newman-Norlund

Faculty Publications

Chronic aphasia, a devastating impairment of language, affects up to a third of stroke survivors. Speech and language therapy has consistently been shown to improve language function in prior clinical trials, but few clinicially applicable predictors of individual therapy response have been identified to date. Consequently, clinicians struggle substantially with prognostication in the clinical management of aphasia. A rising prevalence of aphasia, in particular in younger populations, has emphasized the increasing demand for a personalized approach to aphasia therapy, that is, therapy aimed at maximizing language recovery of each individual with reference to evidence-based clinical recommendations. In this narrative review, …

Soil Volatile Organic Compound Emissions In Response To Soil Warming And Nitrogen Deposition, A. L. Romero-Olivares, C. L. Davie-Martin, M. Kramshoj, R. Rinnan, Serita D. Frey

Faculty Publications

Biogenic volatile organic compounds (VOCs) play crucial roles in ecosystems at multiple scales, ranging from mediating soil microbial interactions to contributing to atmospheric chemistry. However, soil VOCs and how they respond to environmental change remains understudied. We aimed to assess how 2 abiotic global change drivers, soil warming and simulated nitrogen (N) deposition, impact soil VOC emissions over time in a temperate forest. We characterized the effect of warming, N deposition, and their interaction on the composition and emissions of soil VOCs during the growing season of 2 consecutive years. We found that chronic warming and N deposition enhanced total …

Parenting Education For Low-Income Job Seekers: A Mixed-Methods Analysis Of The Parenting With Love And Logic Program, Bryan Spuhler, Jacob A. Esplin, Kay Bradford, Brian J. Higginbotham

Faculty Publications

Although the principles and strategies outlined in Cline and Fay’s (1990) Parenting with Love and Logic have been the foundation for several parent and educator training curricula over the last 30 years, there has been a dearth of empirical research to evaluate these programs (Fay, 2012). Prior research has documented the impact of cumulative family risk factors on parenting skills and child outcomes (Repetti et al., 2002, 2012), but few studies have examined the impact of parenting education courses within unemployed, low-income families. This study investigates perceived parental efficacy across the four program domains of connection, autonomy, regulation, and parental …

Attention/Deficit Hyperactivity Disorder In Adolescent And Young Adult Males With Fragile X Syndrome, Jessica Klusek, Shannon L. O'Connor, Alexandra Hickey, Kimberly J. Hills, Leonard Abbeduto, Jane E. Roberts

Faculty Publications

This study characterized the rates of rates of attention-deficit/hyperactivity disorder (ADHD) in adolescent and young adult males with fragile X syndrome (FXS) using a multi-method approach integrating a DSM-based parent interview (Children’s Interview for Psychiatric Syndromes; P-ChIPS, Fristad et al., 1998) and a parent rating scale (Child Behavior Checklist; CBCL, Achenbach, 2001). Thirty-one males with FXS, aged 16-24 years, participated. Forty-two percent met DSM-5 criteria for ADHD and 35% exceeded the CBCL cut-offs. Agreement between the two classification methods was fair (κ=0.38). Autism symptom severity and nonverbal cognitive ability did not predict ADHD diagnoses/symptoms. Results show …

Key Stakeholder Perspectives On Challenges And Opportunities For Rural Hpv Vaccination In North And South Carolina, Laura J. Fish, Sayward Harrison, Jodi-Ann Mcdonald, Valerie Yelverton, Charnetta Williams, Emmanuel B. Walter, Lavanya Vasudevan

Faculty Publications

The objective of this study was to identify factors at the individual, provider, and systems levels that serve as challenges or opportunities for increasing adolescent vaccination—including Human Papillomavirus (HPV) vaccination—in rural communities in the southern United States (US). As part of a broader study to increase HPV vaccine uptake in the southern US, we conducted in-depth interviews with vaccination stakeholders representing public health and education agencies in North Carolina (NC) and South Carolina (SC). Fourteen key stakeholders were recruited using purposive sampling to obtain insights into challenges and solutions to rural-urban disparities in HPV vaccination coverage. Stakeholders were also queried …

Key Stakeholder Perspectives On Challenges And Opportunities For Rural Hpv Vaccination In North And South Carolina, Laura J. Fish, Sayward Harrison, Jodi-Ann Mcdonald, Valerie Yelverton, Charnetta Williams, Emmanuel B. Walter, Lavanya Vasudevan

Faculty Publications

The objective of this study was to identify factors at the individual, provider, and systems levels that serve as challenges or opportunities for increasing adolescent vaccination—including Human Papillomavirus (HPV) vaccination—in rural communities in the southern United States (US). As part of a broader study to increase HPV vaccine uptake in the southern US, we conducted in-depth interviews with vaccination stakeholders representing public health and education agencies in North Carolina (NC) and South Carolina (SC). Fourteen key stakeholders were recruited using purposive sampling to obtain insights into challenges and solutions to rural-urban disparities in HPV vaccination coverage. Stakeholders were also queried …

Library Diversity And Inclusion Statements In Action, Megan Bresnahan

Faculty Publications

In recent years, many academic libraries have renewed their commitments to advancing equity, diversity, and inclusion (EDI) initiatives in public statements. In this qualitative study, the author interviewed academic librarians to understand how these commitments have been actualized in libraries, and what barriers and challenges have been faced by individuals coordinating this work. All libraries had established committees to implement EDI initiatives, but committees with dedicated positions, budgets, and consistent support from administrators were able to attempt more large-scale, systematic work. The study includes recommendations for library administrators for providing effective structures and support for EDI efforts.

Designing Moocs With Little, Hengtao Tang, Yingxiao Qian Ph.D.

Faculty Publications

Massive Open Online Courses (MOOCs) have been touted as a disruptive innovation with a low-cost and flexible option for opening up higher education. However, existing barriers of MOOCs such as a low retention rate and a low forum participation rate have limited their capacity of serving learners. To strengthen the potential of MOOCs, a compelling design that enables an effective learning experience is needed. This article is aimed to propose a series of design guidelines for MOOCs, namely the LITTLE, as a preliminary design framework for an effective MOOC. The LITTLE includes guidelines such as learner-centered, inquiry-based, technology-enriched, trophy-driven, literature-guided, …

Neural Correlates Of Impaired Vocal Feedback Control In Post-Stroke Aphasia, Roozbeh Behroozmand, Leonardo Bonilha, Chris Rorden, Gregory Hickok, Julius Fridriksson

Faculty Publications

We used left-hemisphere stroke as a model to examine how damage to sensorimotor brain networks impairs vocal auditory feedback processing and control. Individuals with post-stroke aphasia and matched neurotypical control subjects vocalized speech vowel sounds and listened to the playback of their self-produced vocalizations under normal (NAF) and pitch-shifted altered auditory feedback (AAF) while their brain activity was recorded using electroencephalography (EEG) signals. Event-related potentials (ERPs) were utilized as a neural index to probe the effect of vocal production on auditory feedback processing with high temporal resolution, while lesion data in the stroke group was used to determine how brain …

Social Capital, Urbanization Level, And Covid-19 Vaccination Uptake In The United States: A National Level Analysis, Shan Qiao, Zhenlong Li, Jiajia Zhang, Xiaowen Sun, Camryn Garrett, Xiaoming Li

Faculty Publications

Vaccination remains the most promising mitigation strategy for the COVID-19 pandemic. However, existing literature shows significant disparities in vaccination uptake in the United States. Using publicly available national-level data, we aimed to explore if county-level social capital can further explain disparities in vaccination uptake rates when adjusting for demographic and social determinants of health (SDOH) variables, and if association between social capital and vaccination uptake may vary by urbanization level. Bivariate analyses and a hierarchical multivariable quasi-binomial regression analysis were conducted, where the regression analysis was stratified by urban–rural status. The current study suggests that social capital contributes significantly to …

Do We Trust The Government? Attributes Of Covid-19 Vaccine Hesitancy And Acceptance In Nigeria, Osmond C. Ekwebelem, Helen Onyeaka, Ismaeel Yunusa Ph. D., Taghi Miri, Yahwedalu M. Onwuneme, Ayeni T. Eunice, Amara Anyogu, Bright Obi, Ngwogu Ada Carol

Faculty Publications

Objectives:

A significant percentage of the population must be vaccinated to achieve herd immunity. Therefore the success of a vaccination program relies on the level of acceptance. This present study seeks to understand COVID-19 vaccine acceptance and hesitancy in Nigeria by assessing the public's willingness to get vaccinated.

Study design:

This is a population-based cross-sectional study. Data were derived through a structured online survey.

Methods:

A cross-sectional study was conducted among adult residents in Nigeria in March 2021 using a structured online questionnaire. The questionnaire surveyed participants' demographic characteristics and perception of COVID-19 and the COVID-19 vaccine. Descriptive statistics and …

Canonical Sentence Processing And The Inferior Frontal Cortex: Is There A Connection?, Nicholas Riccardi, Chris Rorden, Julius Fridriksson, Rutvik H. Desai

Faculty Publications

The role of left inferior frontal cortex (LIFC) in canonical sentence comprehension is controversial. Many studies have found involvement of LIFC in sentence production or complex sentence comprehension, but negative or mixed results are often found in comprehension of simple or canonical sentences. We used voxel-, region-, and connectivity-based lesion symptom mapping (VLSM, RLSM, CLSM) in left-hemisphere chronic stroke survivors to investigate canonical sentence comprehension while controlling for lexical-semantic, executive, and phonological processes. We investigated how damage and disrupted white matter connectivity of LIFC and two other language-related regions, the left anterior temporal lobe (LATL) and posterior temporal-inferior parietal area …

An Exploration Of How Biophilic Attributes On Campuses Might Support Student Connectedness To Nature, Others, And Self, Susana Alves, Gowri Betrabet Gulwadi, Pia Nilsson

Faculty Publications

University Campuses remain important settings for nurturing and supporting student health and quality of life (QoL). Research shows the health benefits of nature experiences may be facilitated by campus spaces and activities that afford connectedness. Connectedness to nature, others, and self may allow students to cope with mental fatigue, stress, and a constant need for restoration. Despite recent encouraging trends, we still lack an integrative conceptual framework to describe the mechanisms involved in achieving connectedness for making recommendations for campus design. In this conceptual review, we examine students’ connectedness in campus settings in relation to biophilic elements and attributes. We …

Nh’S Workforce: The Youth Retention Initiative For Educational, Occupational And Residential Futures In New Hampshire, Andrew D. Coppens, Sarah Jusseaume, Cindy L. Hartman, Jayson Seaman, Erin H. Sharp, Molly Donovan

Faculty Publications

No abstract provided.

Tell Or Retell? The Role Of Task And Language In Spanish-English Narrative Microstructure Performance, Mary Claire Wofford, Jessica Cano, Lisa A. Fitton Ph.D.

Faculty Publications

Purpose:

This study examined performance of dual language learners (DLLs) on Spanish- and English-language narrative story retells and unique tells. Transcription and analysis focused on comparisons of common microstructural language sample measures in Spanish and English across tasks. Each language sample measure was evaluated for its possible convergence with norm-referenced standardized assessments for DLL children.

Method:

Spanish–English DLLs (N = 133) enrolled in English-only kindergarten or first-grade classrooms completed two-language sample tasks (one in each language), which were transcribed and analyzed using Systematic Analysis of Language Transcripts (Miller & Iglesias, 2017) for measures of syntactic complexity (mean length of …

Materialsatlas.Org: A Materials Informatics Web App Platform For Materials Discovery And Survey Of State-Of-The-Art, Jianjun Hu, Stanislav Stefanov, Yuqi Song, Sadman Sadeed Omee, Steph-Yves Louis, Edirisuriya M.D. Siriwardane, Yong Zhao, Lai Wei

Faculty Publications

The availability and easy access of large-scale experimental and computational materials data have enabled the emergence of accelerated development of algorithms and models for materials property prediction, structure prediction, and generative design of materials. However, the lack of user-friendly materials informatics web servers has severely constrained the wide adoption of such tools in the daily practice of materials screening, tinkering, and design space exploration by materials scientists. Herein we first survey current materials informatics web apps and then propose and develop MaterialsAtlas.org, a web-based materials informatics toolbox for materials discovery, which includes a variety of routinely needed tools for exploratory …

Pro-Inflammatory Diet Pictured In Children With Atopic Dermatitis Or Food Allergy: Nutritional Data Of The Lina Cohort, Olivia Schütte, Larissa Bachmann, Nitin Shivappa Mbbs, Mph, Ph.D., James R. Hébert Scd, Janine F. Felix, Stefan Röder, Ulrich Sack, Michaek Borte, Wieland Kiess, Ana C. Zenclussen, Gabriele I. Stangl

Faculty Publications

Background: Lifestyle and environmental factors are known to contribute to allergic disease development, especially very early in life. However, the link between diet composition and allergic outcomes remains unclear. Methods: In the present population-based cohort study we evaluated the dietary intake of 10-year-old children and analyses were performed with particular focus on atopic dermatitis or food allergy, allergic diseases known to be affected by dietary allergens. Dietary intake was assessed via semi-quantitative food frequency questionnaires. Based on these data, individual nutrient intake as well as children’s Dietary Inflammatory Index (C-DII™) scores were calculated. Information about atopic manifestations during the first …

Mapping Yellow Fever Epidemics As A Potential Indicator Of The Historical Range Of Aedes Aegypti In The United States, Nicole S. Fijman, Donald A. Yee

Faculty Publications

Background: Yellow fever (YF) plagued the United States from the 1690s until 1905, resulting in thousands of deaths. Within the US, Aedes aegypti is the only YF vector and almost no data exists for the location of this species prior to the early 1900s.

Objectives: To determine the historical range of Ae. aegypti we examined the occurrence of YF epidemics across time and space. We hypothesized that historically Ae. aegypti was driven by human population density, like its contemporary range suggests.

Methods: To test this hypothesis, we compiled a list of YF cases in the US, human population density, location, …

Making The World A Better Place Today: Fred Cornforth's Mission, Mindset And Motivation, Beverly Matiko

Faculty Publications

No abstract provided.

Implementation Of An Automated Grading Tool For Phonetic Transcription Training, Marisha Speights Atkins, Dallin J. Bailey, Cheryl D. Seals

Faculty Publications

Clinical phonetic transcription is regarded as a highly specialised skill requiring hours of practice for mastery. Although this skill is a critical part of students’ clinical preparation to become speech-language pathologists, students often report feeling unprepared to apply the skill in clinical practice. Previous studies suggest that increased opportunities for practice and timely feedback on transcriptions are needed in order to develop skill confidence. However, providing more opportunities for practice can be impeded by the limited resources to manage the grading of additional assignments. The purpose of this study is to show the implementation of a web-based learning management system …

Evaluating The Fit-Effectiveness Of Fabric-Based Reusable Face Masks On 3d Printed Niosh Headforms, Casey Stannard, Charles Freeman, Lesley Strawderman, Meagan Moore, Wayne Newhauser, Reuben Burch, Catherine Black, David Saucier

Faculty Publications

No abstract provided.

Exposure To Negative News Stories About Vaping, And Harm Perceptions Of Vaping, Among Youth In England, Canada, And The United States Before And After The Outbreak Of E-Cigarette Or Vaping-Associated Lung Injury (‘Evali’), Katherine East, Jessica L. Reid, Robin Burkhalter, Olivia A. Wackowski, Jim Thrasher Ph.D., Ma, Ms, Harry Tattan-Birch, Christian Boudreau, Maansi Bansal-Travers, Alex C. Liber, Ann Mcneill, David Hammond

Faculty Publications

Introduction

Little is known about the international impact of E-cigarette or Vaping-Associated Lung Injury (‘EVALI’) on youth perceptions of vaping harms. Methods

Repeat cross-sectional online surveys of youth aged 16–19 years in England, Canada, and the United States before (2017, 2018), during (2019 August/September), and after (2020 February/March, 2020 August) the ‘EVALI’ outbreak (N = 63380). Logistic regressions assessed trends, country differences, and associations between exposure to negative news stories about vaping and vaping harm perceptions. Results

Exposure to negative news stories increased between 2017 and February–March 2020 in England (12.6% to 34.2%), Canada (16.7% to 56.9%), and the United …

Maternal Depression Moderated By Family Resources When Children Have Developmental Disabilities., Timothy B. Smith, Terisa P. Gabrielsen

Faculty Publications

Children with developmental disabilities require extensive parental involvement in intervention, but parents with depression may be less able to intervene effectively. We examined prevalence of depression symptoms and predictors among 131 mothers of children with disabilities enrolled in early childhood special education. Participants completed several self-report measures of depression and child and family functioning. Children were directly evaluated using the Battelle Developmental Inventory. One year later, 68 mothers repeated self-report measures. Participants (30%) reported elevated depression symptoms across time. Depression scores were correlated with parental stress and family resources. An interaction between higher maternal depression and higher child functioning with …

Visual Homing For Robot Teams: Do You See What I See?, Damian Lyons, Noah Petzinger

Faculty Publications

Visual homing is a lightweight approach to visual navigation which does not require GPS. It is very attractive for robot platforms with a low computational capacity. However, a limitation is that the stored home location must be initially within the field of view of the robot. Motivated by the increasing ubiquity of camera information we propose to address this line-of-sight limitation by leveraging camera information from other robots and fixed cameras. To home to a location that is not initially within view, a robot must be able to identify a common visual landmark with another robot that can be used …

Visual Homing For Robot Teams: Do You See What I See?, Damian Lyons, Noah Petzinger

Faculty Publications

Visual homing is a lightweight approach to visual navigation which does not require GPS. It is very attractive for robot platforms with a low computational capacity. However, a limitation is that the stored home location must be initially within the field of view of the robot. Motivated by the increasing ubiquity of camera information we propose to address this line-of-sight limitation by leveraging camera information from other robots and fixed cameras. To home to a location that is not initially within view, a robot must be able to identify a common visual landmark with another robot that can be used …