Digital Commons Network^™

Host-Derived Interleukin-1Α Drives Tumor Immunosuppression By Reprogramming Tumor-Associated Myeloid Cells, Manikanda Raja Keerthi Raja, Gourab Gupta, Grace Atkinson, Katie Kathrein, Alissa R. Armstrong, R. Michael Gower, Igor Roninson Ph.D., Eugenia Broude, Mengqian Chen Ph.D., Hao Ji, Chang-Uk Lim, Hongjun Wang, Daping Fan, Peisheng Xu Ph.D., Hexin Chen

Faculty Publications

Myeloid cells are highly heterogeneous and play key roles in establishing an immunosuppressive tumor microenvironment (TME), but the mechanisms controlling their differentiation remain unclear. Using orthotopic murine breast cancer models, we investigated how interleukin-1α (IL-1α) influences this process. Deletion of host Il1α resulted in rejection of transplanted tumors. Single-cell RNA sequencing identified CX3CR1⁺ macrophages as the main source of IL-1α in the TME. Il1α deficiency disrupted monocyte–macrophage differentiation, reducing CX3CR1⁺ macrophages and increasing iNOS⁺ macrophages. Myeloid cells from Il1α⁻/⁻ hosts induced lower PD-1 and CTLA-4 expression in co-cultured CD8⁺ T cells than those from wild-type hosts. CellChat analysis showed …

The Incorporation Of Ai-Enabled Culturally Relevant Narrative-Based Learning Pedagogy To Engage Students In A Diverse Stem Classroom, Nitin U. Jain, Eliza G. Braden

Faculty Publications

This study explores how AI-enabled, culturally relevant, narrative-based learning pedagogy influences engagement among ninth-grade students in an Earth Science course. Conducted in two classrooms in a southeastern U.S. school predominantly attended by African American and Latinx students, we developed lesson plans on Earth Systems and Climate Change. Using a qualitative case study design, we examined one educator's implementation of AI-enhanced lessons. Thematic analysis of exit surveys and students' artifacts revealed that narrative-based learning significantly increased students' desire, engagement, and confidence in scientific concepts compared to conventional methods. This approach allowed students to integrate local and global knowledge, fostering deep questions …

Distributed Model Predictive Control-Based Power Management Scheme For Grid-Integrated Microgrids, Sergio Escareno, Sijo Augustine, Liang Sun, Sathishkumar J. Ranade, Olga Lavrava, Enrico Pontelli, John Hedengren

Faculty Publications

Transitioning from traditional electrical grids to smart grids is currently an ongoing process that many nations are striving for due to their access to renewable resources. Energy management is one of the key parameters that decides the performance of such complex systems. Distributed Model Predictive Control (DMPC) is a promising technique that can be used to improve the energy management of grid-connected systems. This paper analyzes a grid-connected inverter system with DMPC that exchanges key operating parameters with the grid to optimize coordinated power sharing between its respective loads. The state-space model for the inverter is derived and verified to …

Jwst Interferometric Imaging Reveals The Dusty Torus Obscuring The Supermassive Black Hole Of Circinus Galaxy, Enrique Lopez Rodriguez, Joel Sanchez-Bermudez, Omaira González-Martín, Robert Nikutta, Ryan M. Lau, Deepashri Thatte, Julien H. Girard, Ismael García-Bernete, Matthew J. Hankins

Faculty Publications

The dusty and molecular torus is an elusive structure surrounding supermassive black holes, yet its importance is unequivocal for understanding feedback and accretion mechanisms. The torus and accretion disk feed the inspiraling gas onto the active nucleus, launching outflows that fundamentally connect the active nucleus’s activity to the host galaxy. In this work, we utilize the aperture-masking interferometric mode onboard the JWST to achieve a resolution of 0.08" at 4.3 μm and bring out the fainter features in the central 10 pc of the Circinus galaxy. We show that most of the dust mass is located along the equatorial …

Cortical Hierarchy And Aphasia Severity: The Sensorimotor–Association Gradient Modulates Lesion Effects Within Language-Specific Networks, Ida Rangus, Natalie Busby, Nicholas Riccardi, Sigfus Kristinsson, Janina Wilmskoetter, Dirk B. Den Ouden, Chris Rorden, Roger Newman-Norlund, Julius Fridriksson Ph.D., Leonardo Bonilha

Faculty Publications

Aphasia severity after stroke varies widely and is not fully explained by lesion size or location. We propose that incorporating the brain’s sensorimotor-association (S-A) gradient, reflecting cortical hierarchy, offers a biologically grounded framework for predicting language outcomes. In 236 individuals with chronic left-hemisphere stroke, we examine whether the hierarchical position of lesions in language-specific (LS) and domain-general (DG) areas modulates aphasia severity. We parcellate lesions using a cortical atlas and weigh them by each region’s S-A rank. We apply hierarchical linear regression to test whether S-A ranking and its interaction with lesion volume improves prediction of Western Aphasia Battery-Revised Aphasia …

Temperature Dependent High Frequency Performance Of A 62% Algan Channel Hemt, Jiahao Chen, Abdullah Al Mamun Mazumder, Parthasarathy Seshadri, Dheekshinn Nandakumar, Ruixin Bai, Rafael Andrew Choudhury, M. Asif Khan, Chirag Gupta

Faculty Publications

This article reports on the temperature dependent performance of a HEMT with an Al_0.62Ga_0.38N channel layer and an Al_0.84Ga_0.16N barrier layer grown by metal–organic chemical vapor deposition. The device in this report was measured at room temperature and elevated temperatures of 100–150 °C. The sheet resistance increased from 3.5 kΩ/sq (25 °C) to 5.4 kΩ/sq (150 °C), while the contact resistance remained nominally similar. For a device with 160 nm gate length and 2 µm source-to-drain length, excellent electrical characteristics have been achieved when the device was operated at 150 °C with …

Optimal Placement Of Electric Vehicle Chargers: A Mixed-Integer Linear Programming Model, Joubin Zahiri Khameneh, Emmanuel Fagbenle

Faculty Publications

Electric vehicle adoption is growing, but New Hampshire lags in public charging infrastructure, especially in rural areas. This gap increases range anxiety and economic inefficiencies. In this study, we developed a mixed-integer linear programming (MILP) model to optimally locate new electric vehicle chargers statewide, maximizing coverage and equity under budget constraints. The model includes geographic coverage requirements, population-weighted equity, capacity limits, and a $28 million budget. Moreover, the model recommends 855 Level 2 chargers and 149 Direct Current Fast Chargers (DCFCs) across 247 ZIP Codes, nearly doubling public charging capacity and achieving 98.8% coverage within defined service radii. The plan …

Comparing The Cognitive And Physiological Effects Of Traditional And Virtual Reality Exercise In Overweight/Obese Adults: A Pilot Study, Emma Kelsey, Greta Ness, Grayce Bjugan, Darci Wiseman, Terence Moriarty

Faculty Publications

Research suggests that overweight/obese adults (BMI ≥ 25 kg/m²) have an elevated risk of cognitive decline. Although exercise is recommended to improve both physical and cognitive health, adherence is often low in this population. Virtual reality (VR) is an emerging strategy that may enhance exercise engagement. This pilot study compared the effects of traditional (TRAD) cycling and VR-based exercise on cognitive performance and prefrontal cortex (PFC) oxygenation (O2Hb). Eleven adults (M = 6, F = 5; BMI: 31.1 ± 2.8 kg/m²; VO2max: 30.4 ± 5.7 mL/kg/min) completed a VO2max test and two 16 min moderate-intensity cycling …

Risk And Public Judgments On Police Pursuits: A Nationally Representative Conjoint Experiment, Scott M. Mourtgos, Ian T. Adams, Kyle Mclean, Geoffrey P. Alpert

Faculty Publications

Police vehicle pursuits emphasize a central tension between law enforcement imperatives and public safety. While modern policies emphasize balancing apprehension needs against risks of continuation, little is known about whether public intuitions mirror this framework. We address this gap using a nationally representative conjoint experiment (N = 3,334) that varied eleven contextual factors across randomized pursuit scenarios. Respondents rated perceived risk, indicated whether pursuits should be terminated, and made forced-choice tradeoffs. Across all outcomes, high-risk situational factors (e.g., high speeds, adverse weather, heavy traffic, urban settings, etc.) increased perceived danger and termination support, while more serious underlying offenses, particularly …

Turning Risks Of Cheating With Ai Into Opportunities For Better Teaching, John M. Lande

Faculty Publications

Many law school faculty are concerned that students may misuse artificial intelligence (AI) tools to undermine their learning and violate academic integrity policies.  Although some students will inevitably cheat, faculty can reduce the risk – and improve student learning – by rethinking assignment design and classroom communication.

This article frames the risk of AI-related cheating as an opportunity for pedagogical improvement.  It offers practical strategies to help faculty design assignments that enhance student learning, promote good decision-making, discourage inappropriate AI use, and foster responsible AI literacy.  It outlines approaches consistent with the ABA’s new requirement for formative assessment throughout the …

Back To The Drawing Board? Overdraft Fees, The Congressional Review Act, And The Cfpb's Path Back To Consumer Protection, Kaitlin A. Caruso

Faculty Publications

In late 2024, the Consumer Financial Protection Bureau adopted a rule aimed at addressing a longtime pain point for consumers: high, sometimes unpredictable, overdraft fees. The CFPB predicted that the rule would save consumers billions of dollars per year. But it was not to be. The second Trump Administration has taken unprecedented, sometimes unlawful, action to incapacitate and dismantle the CFPB. The President and Congress have also worked together to use an unusual statutory tool, the Congressional Review Act, to not only to kill the overdraft rule but also keep the CFPB from adopting any regulation that is “substantially the …

Humanizing The Base Of The Pyramid: Exploring The Influence Of Resource (Dis)Advantages On Value Creation, Ted London, Lisa Jones Christensen, Tyson Mackey, Alison Mackey, Heather Esper, Andrew Grogan-Kaylor

Faculty Publications

Base of the pyramid (BoP) scholarship emphasizes the potential for enterprises to generate profits by enhancing the wellbeing of the impoverished, often by selling socially-beneficial products (SBPs). Yet, many such BoP enterprises have experienced mixed results. We argue that this may stem from insufficient attention to how BoP consumers value SBPs and other products. We frame SBPs as a type of human capital investment and thus use human capital theory to study how the consumption of SBPs does or does not create value for consumers. Specifically, we use a novel data set from rural India to measure value creation in …

Gambling Away Stability: Sports Betting’S Impact On Vulnerable H, Scott R. Baker, Justin Balthrop, Mark J. Johnson, Jason Kotter, Kevin Pisciotta

Faculty Publications

We estimate the causal effect of online sports betting on households’ investment, spending, and debt management decisions using household transaction data and a staggered difference-in-differences framework. Following legalization, sports betting spreads quickly, with both the number of participants and frequency of bets increasing over time. This increase does not displace other gambling or consumption but significantly reduces savings, as risky bets crowd out positive expected value investments. These effects concentrate among frequent bettors and low-savings households. Our findings highlight the potential adverse effects of online sports betting on vulnerable households.

The Trial Of Socrates, Jonathan Van Patten

Faculty Publications

In many important ways, the trial of Socrates was not just the trial of the century, nor even the trial of the millennium. It predated the trial of Jesus, which is important for many other reasons, but Socrates’ contribution to how we think about justice and the rule of law is without equal. This Article explores the ways that this fifth-century B.C. trial, located geographically on the margin of what came to be known as the West, is at the center of what makes us a civilization. It is not simply about the drama, nor the politics of free inquiry, …

Regulatory History And Judicial Review, Todd Phillips, Anthony L. Moffa

Faculty Publications

The Administrative Procedure Act requires federal agencies to simply "incorporate in the rules adopted a concise general statement of their basis and purpose" after they receive comments from the public, and the Supreme Court ruled in Overton Park that courts are to adjudicate whether rules are arbitrary and capricious based on agencies' contemporaneous rationales. Judge-created doctrines incentivize agencies to rely on these "concise" statements to elucidate their rationales, and as a result, rulemaking preambles have ballooned in size as agencies seek to insulate themselves from critical courts.

This article contends that although the APA's statutory requirement is in tension with …

Fda After Loper Bright, Erika Lietzan

Faculty Publications

Loper Bright, which overruled the Chevron decision from 1984, tells us that a court should determine the meaning of all statutory provisions for itself, rather than deferring to the views of the federal agencies that implement those provisions. But the overruling of Chevron may have less of an impact on the U.S. Food and Drug Administration than conventional wisdom supposes. Most challenges to FDA action do not concern its statutory interpretations. And the agency prevailed in most cases involving statutory interpretation, before the Chevron doctrine took hold. After 1984, when the doctrine did apply, the agency often lost cases at …

Why Ai May Be Your Best Negotiation And Mediation Coach, John Lande

Faculty Publications

This article explores the role of artificial intelligence (AI) tools as negotiation and mediation coaches.  Drawing on research from negotiation, mediation, and consumer behavior, the article explains why bots can sometimes coach more effectively than humans.  In this role, they offer on-demand support that can help users prepare strategically and reflect honestly.  This support is especially valuable when seeking help from a human would feel too risky or awkward.

The article cautions against use of AI for roles requiring emotional intelligence, discretion, or legitimacy, such as negotiators, mediators, or arbitrators.  It distinguishes between AI as a thinking partner and AI …

Navigating Racist Spaces Through Radical Self-Care: A Photovoice Exploration Of The Experiences Of Black Graduate Students, Laetitia Adelson, Cherese Fine, Dion Harry, Keneisha Harrington, Rebecca Lynn Morgan Ph.D., Tomiko Smalls, Jerad Green, Courtney Allen, Anuoluwapo Bankole, Robin Phelps-Ward

Faculty Publications

This manuscript examines the impact of racist campus climates for Black graduate students at a predominantly white institution. Using a photovoice methodological design, this study illuminates students’ ability to thrive through radical self-care despite the many racist factors, incidents, and systems at the institution. The paper ends with recommendations for improving campus racial climate in graduate education.

Moving Forward Together For Cancer Recovery: Collaborative Guide For Researchers And Cancer Care Organizations, M. Madison Kindred, Karen E. Wickersham, Daneille E. Ostendorf, Bernardine M. Pinto

Faculty Publications

No abstract provided.

A Comprehensive Survey On Facial Expression Generation: From Gans To Llm-Guided Multimodal Models, Murad Hasan, Rabab Abdelfattah, Kareem Abdelfatah, Mostafa Fouda, Ahmed Sherif

Faculty Publications

Facial expression generation (FEG) has emerged as a vital area in human–computer interaction, virtual avatars, and affective computing, aiming to synthesize natural and expressive facial behaviors across diverse interaction contexts. This survey presents a comprehensive analysis of recent advances in FEG, organized into six key paradigms: speech-driven expression generation, facial reaction generation, face video generation, facial animation, avatar-based generation, and text-driven expression generation. We review a wide range of model architectures, including VQ-VAEs, Generative Adversarial Networks (GANs), 3D Morphable Models (3DMMs), Transformers, and diffusion-based approaches, and compare their performance using commonly adopted evaluation metrics such as Fréchet Distance (FD), Peak …

Building Capacity, Driving Impact: A Landscape Analysis Of Community Engagement And Outreach Cores' Activities, Emily Frankel, Stephanie Broyles, Stephenie Kennedy-Rea, Casey Solsrud, Elizabeth K. Woods, Deborah Goebert, Zsolt Nagykaldi, Holly Huye, Lee M. Pachter

Faculty Publications

Community Engagement and Outreach (CEO) Cores are a key component of the IDeA Clinical and Translational Research (IDeA-CTR) Program, serving to develop and implement capacity-building initiatives that empower communities to engage and collaborate with investigators in community-engaged research. To strengthen collaboration and shared learning across sites, a CEO Special Interest Group was established. In 2022, the group conducted a landscape analysis to systematically characterize and categorize CEO Core activities across the IDeA-CTR network, with a focus on capacity-building efforts related to knowledge transfer, co-learning, and infrastructure development. The analysis revealed several common approaches to community engagement and capacity building across …

Do Audit Partner And Audit Committee Member Ideologies Influence Engagement Partner Selection And Financial Reporting Oversight Effectiveness?, Robert Felix, Sattar Mansi, Mikhail Pevzner, Timothy Seidel

Faculty Publications

This study examines whether the ideological orientation of the audit partner and audit committee members— defined as their personal belief systems and inclinations, including their attitude toward risk, ambiguity, and novelty—has an impact on engagement partner selection and the effectiveness of oversight in the financial reporting process. Drawing on prior evidence that the two main US political parties reflect different ideologies, we hand-collect political donation data to construct ideological scores for audit partners and audit committee members. Our findings highlight several intriguing relationships. First, audit committees are more likely to select an ideologically dissimilar partner. Second, greater ideological dissimilarity between …

A First Amendment Right To Know, David S. Ardia

Faculty Publications

This Article tackles an increasingly important question: Can police round up people on American streets and keep secret the names of those they detain without violating the First Amendment? Alarmingly, the government made this very argument in the summer of 2020 when it sought to break up Black Lives Matter protests occurring in cities across the country. Based in part on a Supreme Court decision from the 1970s involving access to prisons, the government argued that the First Amendment imposes no constraints on government secrecy. If it is true that the government can shield its exercise of police power from …

At The Intersection Of Property And Disaster Recovery, Jeanne Ortiz-Ortiz

Faculty Publications

(Excerpt)

When disaster strikes, communities rally to meet urgent, short-term needs—food, shelter, and medical care that keep people alive and safe in the immediate aftermath. For days, we see images of flooded streets, emergency shelters, and calls to support fundraising campaigns in the media cycle. Long-term recovery after a disaster often depends on something less visible: the ability of people, especially those experiencing economic insecurity, to rebuild or return to stable, functional homes.

The outcome of this largely depends on whether families can navigate and access assistance programs like those offered by the Federal Emergency Management Agency (FEMA). Can you …

Using Network Models To Understand Biological Signaling Architecture, Russ White, Emily Brown Reeves, Gerald L. Fudge

Faculty Publications

Engineers have developed abstract network models to better understand the recurring problems faced by communication systems. This paper argues that these models can be generalized to describe biological communications systems given that they share many requirements with human-designed systems, including functional requirements and physical constraints. Leveraging collaboration, biologists and engineers can work together to use well-understood communication systems, designed to carry data across a computer network, as a model for analyzing less well-understood biological communication systems in order to make predictions and uncover previously unknown functionalities. To illustrate this approach, we apply the Recursive Internet Network Architecture model (RINA) to …

Workshop Outcomes Report: 2nd International Workshop On Seismic Resilience Of Arctic Infrastructure And Social Systems, Majid Ghayoomi, Daniela Morganti

Faculty Publications

The report provides an overview of the second international workshop on Seismic Resilience of Arctic Infrastructure and Social Systems. The report discusses agenda, workshop activities, interdisciplinary working groups, and results. It ends with several strategic questions and investigation plans that were developed as part of the workshop activities.

My Negotiation Chatbot Toby And Pedagogical Governance, Renee Henson

Faculty Publications

The use of artificial intelligence (AI) chatbots is exploding. Adolescents increasingly prefer interactions with AI companions over peers. Adults rely on these systems for health planning, therapy, administrative assistance, nutrition guidance, and even simulated “romantic relationships.” Individuals and institutions are adopting AI tools at a pace that far exceeds the development of governance frameworks.

I developed Toby for use in my first-year Lawyering: Problem-Solving and Dispute Resolution (“Lawyering”) course to expose students to the dynamics of negotiating against an opposing counsel with a difficult personality—a type of adversary all too common in legal practice, yet difficult to prepare for. Toby …

Effect Of Density Irregularities On Radio Frequency Wave Propagation In Ionospheric Plasmas, Eun-Hwa Kim, Jay Johnson, Syun'ichi Shiraiwa, Nicola Bertelli, Masayuki Ono, Simon Wing

Faculty Publications

No abstract provided.

Mental And Physical Humanlikeness In Artificial Intelligence Influencers: Effects On Humanness, Eeriness, And Consumer Responses, Terry Kim Ph.D., Hyunjoo Im

Faculty Publications

Artificial intelligence (AI) influencers, nonhuman characters powered by AI, have garnered a significant following on social media in recent years. Through two between-subjects online experiments (n = 957), this study investigates the impact of AI influencers' appearance realism and self-disclosure on consumer perceptions (humanness and eeriness) and their downstream responses (intention to self-disclose, intention to follow the advice, and brand attitude). Drawing from anthropomorphism and theory of mind, this study emphasizes the distinction of two dimensions of AI influencers' humanlikeness (physical and mental) which differently affect the humanness and eeriness of the AI influencer. Results indicate that the AI …

De-Skilling Or Re-Skilling? The Case For Smarter Writing Assignments, John Lande

Faculty Publications

This article challenges the assumption that AI inevitably leads to the de-skilling of law students.  Some faculty understandably fear that students will use AI to bypass critical thinking and avoid meaningful effort.  This article reframes AI as a potential catalyst for improving legal education rather than inherently a threat.

Concerns about de-skilling generally are based on the assumption that faculty will not change traditional writing assignments.  This article analyzes why these assignments often fail to help students develop strong analytical and writing skills. These include limited instruction in basic writing skills, poor design, lack of feedback, and faculty inertia in …