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Angiogenic Deficiency And Adipose Tissue Dysfunction Are Associated With Macrophage Malfunction In Sirt1 -/- Mice, Fen Xu, David Burk, Zhanguo Gao, Jun Yin, Xia Zhang, Jianping Weng, Jianping Ye Apr 2012

Angiogenic Deficiency And Adipose Tissue Dysfunction Are Associated With Macrophage Malfunction In Sirt1 -/- Mice, Fen Xu, David Burk, Zhanguo Gao, Jun Yin, Xia Zhang, Jianping Weng, Jianping Ye

Faculty Publications

The histone deacetylase sirtuin 1 (SIRT1) inhibits adipocyte differentiation and suppresses inflammation by targeting the transcription factors peroxisome proliferator-activated receptor γ and nuclear factor κB. Although this suggests that adiposity and inflammation should be enhanced when SIRT1 activity is inactivated in the body, this hypothesis has not been tested in SIRT1 null (SIRT1 -/-) mice. In this study, we addressed this issue by investigating the adipose tissue in SIRT1 -/-mice. Compared with their wild-type littermates, SIRT1 null mice exhibited a significant reduction in body weight. In adipose tissue, the average size of adipocytes was smaller, the content of extracellular matrix …

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Plant Science In Forest Canopies - The First 30 Years Of Advances And Challenges (1980-2010), Margaret D. Lowman, Timothy D. Schowalter Apr 2012

Plant Science In Forest Canopies - The First 30 Years Of Advances And Challenges (1980-2010), Margaret D. Lowman, Timothy D. Schowalter

Faculty Publications

Contents: Summary 12 I. Introduction 12 II. History of canopy access 13 III. Consequences of whole-tree approaches to forest science 15 IV. Canopy communities - their inhabitants, environment, and processes 16 V. The role of forest canopies in providing ecosystem services 21 VI. Using canopy science as a 'hook' to inspire forest conservation 21 VII. Conclusions -'black boxes' in canopy science that remain 22 Acknowledgements 23 References 24 Summary: As an emerging subdiscipline of forest biology, canopy science has undergone a transition from observational, 'oh-wow' exploration to a more hypothesis-driven, experimental arena for rigorous field biology. Although efforts to explore …

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Ultraconserved Elements Are Novel Phylogenomic Markers That Resolve Placental Mammal Phylogeny When Combined With Species-Tree Analysis, John E. Mccormack, Brant C. Faircloth, Nicholas G. Crawford, Patricia Adair Gowaty, Robb T. Brumfield, Travis C. Glenn Apr 2012

Ultraconserved Elements Are Novel Phylogenomic Markers That Resolve Placental Mammal Phylogeny When Combined With Species-Tree Analysis, John E. Mccormack, Brant C. Faircloth, Nicholas G. Crawford, Patricia Adair Gowaty, Robb T. Brumfield, Travis C. Glenn

Faculty Publications

Phylogenomics offers the potential to fully resolve the Tree of Life, but increasing genomic coverage also reveals conflicting evolutionary histories among genes, demanding new analytical strategies for elucidating a single history of life. Here, we outline a phylogenomic approach using a novel class of phylogenetic markers derived from ultraconserved elements and flanking DNA. Using species-tree analysis that accounts for discord among hundreds of independent loci, we show that this class of marker is useful for recovering deep-level phylogeny in placental mammals. In broad outline, our phylogeny agrees with recent phylogenomic studies of mammals, including several formerly controversial relationships. Our results …

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Genomic Insights Into Adaptation To High-Altitude Environments, Z. A. Cheviron, R. T. Brumfield Apr 2012

Genomic Insights Into Adaptation To High-Altitude Environments, Z. A. Cheviron, R. T. Brumfield

Faculty Publications

Elucidating the molecular genetic basis of adaptive traits is a central goal of evolutionary genetics. The cold, hypoxic conditions of high-altitude habitats impose severe metabolic demands on endothermic vertebrates, and understanding how high-altitude endotherms cope with the combined effects of hypoxia and cold can provide important insights into the process of adaptive evolution. The physiological responses to high-altitude stress have been the subject of over a century of research, and recent advances in genomic technologies have opened up exciting opportunities to explore the molecular genetic basis of adaptive physiological traits. Here, we review recent literature on the use of genomic …

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Improvement Of Performance Of Cardiac Spect Camera Using Curved Detectors With Pinholes, Joyoni Dey Apr 2012

Improvement Of Performance Of Cardiac Spect Camera Using Curved Detectors With Pinholes, Joyoni Dey

Faculty Publications

SPECT is primarily used in the clinic for cardiac myocardial perfusion imaging. However, for SPECT, sensitivity is impaired due to the need for collimation. System resolution FWHM is poor as well (∼ 1 cm). In this work the resolution of a curved detector was theoretically derived. The advantage of a curved detector over a flat detector with pinhole collimation was demonstrated for cardiac applications using theoretical derivations as well as a ray-tracing voxel-based forward projector. For the flat detector using parameters close to what was expected for the new multi-pinhole GE Discovery system, it is shown that using a paraboloid …

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Tall Jalul 2012, Paul Z. Gregor Apr 2012

Tall Jalul 2012, Paul Z. Gregor

Faculty Publications

No abstract provided.

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Dispersal Behavior Correlates With Personality Of A North American Fish, Josh E. Rasmussen, Mark C. Belk Apr 2012

Dispersal Behavior Correlates With Personality Of A North American Fish, Josh E. Rasmussen, Mark C. Belk

Faculty Publications

The process of dispersal is determined by the interaction of individual (intrinsic) traits and environmental (extrinsic) factors. Although many studies address and quantify dispersal, few evaluate both intrinsic and extrinsic factors jointly. We test the relative importance of intrinsic traits (exploration tendency and size) and extrinsic factors (population density and habitat quality) on dispersal of a medium-sized western United States minnow, southern leatherside chub Lepidomeda aliciae. A generalized linear model with a binomial response was used to determine the probability of individuals dispersing one year after tagging. Medium-sized individuals that were more prone to explore novel environments were 10.7 …

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Role Of Raltegravir In Hiv-1 Management, Kristina E. Rokas, P Brandon Bookstaver, Caitlin L. Shamroe, S Scott Sutton, Vanessa E. Millisor, Jacquelyn E. Bryant, Sharon B. Weissman Apr 2012

Role Of Raltegravir In Hiv-1 Management, Kristina E. Rokas, P Brandon Bookstaver, Caitlin L. Shamroe, S Scott Sutton, Vanessa E. Millisor, Jacquelyn E. Bryant, Sharon B. Weissman

Faculty Publications

OBJECTIVE: To review the literature concerning the role of raltegravir in the treatment of HIV-1 in antiretroviral (ARV)-experienced and ARV-naïve patients. DATA SOURCES: A PubMed search was conducted for published data through March 2012 using the search terms raltegravir, MK-0518, and integrase strand transfer inhibitor. An additional search of International Pharmaceutical Abstracts for unpublished data, including data from the Infectious Diseases Society of America, the Conference on Retroviruses and Opportunistic Infections, the International AIDS Society, and the Interscience Conference on Antimicrobial Agents and Chemotherapy, was conducted using similar search terms. STUDY SELECTION AND DATA EXTRACTION: In vitro and in vivo …

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Education's Elusive Future, Storied Past, And The Fundamental Inequity In Between, Derek W. Black Apr 2012

Education's Elusive Future, Storied Past, And The Fundamental Inequity In Between, Derek W. Black

Faculty Publications

No abstract provided.

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Diversity Of Tanaidacea (Crustacea: Peracarida) In The World's Oceans - How Far Have We Come?, Gary Anderson, Magdalena Blazewicz-Paszkowycz, Roger Bamber Apr 2012

Diversity Of Tanaidacea (Crustacea: Peracarida) In The World's Oceans - How Far Have We Come?, Gary Anderson, Magdalena Blazewicz-Paszkowycz, Roger Bamber

Faculty Publications

Tanaidaceans are small peracarid crustaceans which occur in all marine habitats, over the full range of depths, and rarely into fresh waters. Yet they have no obligate dispersive phase in their life-cycle. Populations are thus inevitably isolated, and allopatric speciation and high regional diversity are inevitable; cosmopolitan distributions are considered to be unlikely or non-existent. Options for passive dispersion are discussed. Tanaidaceans appear to have first evolved in shallow waters, the region of greatest diversification of the Apseudomorpha and some tanaidomorph families, while in deeper waters the apseudomorphs have subsequently evolved two or three distinct phyletic lines. The Neotanaidomorpha has …

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The Future Of Nursing: How Important Is Discipline-Specific Knowledge? A Conversation With Jacqueline Fawcett, Janie B. Butts, Karen L. Rich, Jacqueline Fawcett Apr 2012

The Future Of Nursing: How Important Is Discipline-Specific Knowledge? A Conversation With Jacqueline Fawcett, Janie B. Butts, Karen L. Rich, Jacqueline Fawcett

Faculty Publications

Nurses have long attempted to secure a unique identity for the profession. Many scholars are now promoting an interdisciplinary framework for nursing practice. Fawcett is convinced that interdisciplinary practice poses a danger for nursing to lose its identity and that interdisciplinary practice cannot be successful if members of each discipline do not understand the conceptual models, practice, and research of their own discipline. Dr. Janie Butts and Dr. Karen Rich interviewed Dr. Jacqueline Fawcett about her views related to discipline-specific knowledge and nursing's future. The authors conclude that Fawcett's scientific foundation gives nursing the solidarity and power necessary to determine …

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Mediation And Post-Election Litigation: A Way Forward, Rebecca Green Apr 2012

Mediation And Post-Election Litigation: A Way Forward, Rebecca Green

Faculty Publications

No abstract provided.

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A Functional Approach To Risks And Uncertainties Under Nepa, Todd S. Aagaard Apr 2012

A Functional Approach To Risks And Uncertainties Under Nepa, Todd S. Aagaard

Faculty Publications

The National Environmental Policy Act (NEPA) mandates that federal agencies evaluate the environmental impacts of their proposed actions. This requires agencies to make ex ante predictions about environmental consequences that often involve a significant degree of factual risk or uncertainty. Considerable controversy exists regarding how agencies should address such risks and uncertainties. Current NEPA law adopts a largely ad hoc approach that lacks coherence and analytical rigor. Some environmentalists and legal scholars have called for a greater emphasis on worst-case analysis in environmental planning, especially after the recent Deepwater Horizon oil spill in the Gulf of Mexico and the meltdowns …

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The Effects Of Video Formats In Online News: A Study Of Recall And Stickiness, August Grant, Diane Guerrazzi, Jack Karlis Apr 2012

The Effects Of Video Formats In Online News: A Study Of Recall And Stickiness, August Grant, Diane Guerrazzi, Jack Karlis

Faculty Publications

News organizations putting content on their websites may better engage their audience by offering a choice of raw video rather than packages. A two-by-three experiment studied the relationships among video format, time spent, and recall for online news. Test subjects viewed a traditional, broadcast-type standard news “package,” a disassembled package, and raw video with text. Results showed users spent significantly more time with the raw video format than with the other two formats. Time spent was strongly correlated with post-test recall of elements of each story, but there was no direct relationship between format and recall. A model is proposed …

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Ototoxic Hearing Loss And Retinoblastoma Patients, Shaum Bhagat Mar 2012

Ototoxic Hearing Loss And Retinoblastoma Patients, Shaum Bhagat

Faculty Publications

Chemotherapy is often used in the conservative management of retinoblastoma. Chemotherapy drugs, while ameliorative, can produce long-lasting side effects that potentially can affect survivor quality of life. Carboplatin is a common chemotherapy agent with known ototoxic side effects that is used in the treatment of retinoblastoma (Rodriguez-Galindo et al., 2003). The potential for carboplatin-induced hearing loss is of concern to the medical professional, given that retinoblastoma is often diagnosed in early childhood and children with retinoblastoma have visual impairments. This chapter will outline the mechanisms underlying carboplatin ototoxicity. The extent of knowledge concerning the pathophysiology of carboplatin-induced hearing loss will …

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Reply To Jenkins Et Al.: Evidence For Contaminating Oil Exposure Is Closely Linked In Space And Time To Biological Effects, Andrew Whitehead, Benjamin Dubansky, Charlotte Bodinier, Tzintzuni I. Garcia, Scott Miles, Chet Pilley, Vandana Raghunathan, Jennifer L. Roach, Nan Walker, Ronald B. Walter, Charles D. Rice, Fernando Galvez Mar 2012

Reply To Jenkins Et Al.: Evidence For Contaminating Oil Exposure Is Closely Linked In Space And Time To Biological Effects, Andrew Whitehead, Benjamin Dubansky, Charlotte Bodinier, Tzintzuni I. Garcia, Scott Miles, Chet Pilley, Vandana Raghunathan, Jennifer L. Roach, Nan Walker, Ronald B. Walter, Charles D. Rice, Fernando Galvez

Faculty Publications

No abstract provided.

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The Facebook Effect: Secondary Markets And Insider Trading In Today's Startup Environment, Stephen F. Diamond Mar 2012

The Facebook Effect: Secondary Markets And Insider Trading In Today's Startup Environment, Stephen F. Diamond

Faculty Publications

The dismissal of a senior Facebook employee in connection with the purchase of Facebook shares on a private resale trading platform last year raised new concerns about secondary trading in the securities of private companies and insider trading. This practitioner-oriented essay explores these issues and suggests that startup companies consider adopting a variation on the standard insider trading policy widely adopted by public companies. The discussion is important in light of new attention being paid by regulators to insider trading as well as a debate in Congress about barriers to raising capital for smaller companies.

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Buffalo, Bush Meat, And The Zoonotic Threat Of Brucellosis In Botswana, Kathleen Anne Alexander, Jason Kenna Blackburn, Mark Eric Vandewalle, Risa Pesapane, Eddie Kekgonne Baipoledi, Phil H. Elzer Mar 2012

Buffalo, Bush Meat, And The Zoonotic Threat Of Brucellosis In Botswana, Kathleen Anne Alexander, Jason Kenna Blackburn, Mark Eric Vandewalle, Risa Pesapane, Eddie Kekgonne Baipoledi, Phil H. Elzer

Faculty Publications

Background: Brucellosis is a zoonotic disease of global importance infecting humans, domestic animals, and wildlife. Little is known about the epidemiology and persistence of brucellosis in wildlife in Southern Africa, particularly in Botswana. Methods: Archived wildlife samples from Botswana (1995-2000) were screened with the Rose Bengal Test (RBT) and fluorescence polarization assay (FPA) and included the African buffalo (247), bushbuck (1), eland (5), elephant (25), gemsbok (1), giraffe (9), hartebeest (12), impala (171), kudu (27), red lechwe (10), reedbuck (1), rhino (2), springbok (5), steenbok (2), warthog (24), waterbuck (1), wildebeest (33), honey badger (1), lion (43), and zebra (21). …

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Preserving And Using Germplasm And Dissociated Embryonic Cells For Conserving Caribbean And Pacific Coral, Mary Hagedorn, Virginia Carter, Kelly Martorana, Malia K. Paresa, Jason Acker, Iliana B. Baums, Eric Borneman, Michael Brittsan, Michael Byers, Michael Henley, Michael Laterveer, Jo Ann Leong, Megan Mccarthy, Stuart Meyers, Brian D. Nelson, Dirk Petersen, Terrence Tiersch, Rafael Cuevas Uribe, Erik Woods, David Wildt Mar 2012

Preserving And Using Germplasm And Dissociated Embryonic Cells For Conserving Caribbean And Pacific Coral, Mary Hagedorn, Virginia Carter, Kelly Martorana, Malia K. Paresa, Jason Acker, Iliana B. Baums, Eric Borneman, Michael Brittsan, Michael Byers, Michael Henley, Michael Laterveer, Jo Ann Leong, Megan Mccarthy, Stuart Meyers, Brian D. Nelson, Dirk Petersen, Terrence Tiersch, Rafael Cuevas Uribe, Erik Woods, David Wildt

Faculty Publications

Coral reefs are experiencing unprecedented degradation due to human activities, and protecting specific reef habitats may not stop this decline, because the most serious threats are global (i.e., climate change), not local. However, ex situ preservation practices can provide safeguards for coral reef conservation. Specifically, modern advances in cryobiology and genome banking could secure existing species and genetic diversity until genotypes can be introduced into rehabilitated habitats. We assessed the feasibility of recovering viable sperm and embryonic cells post-thaw from two coral species, Acropora palmata and Fungia scutaria that have diffferent evolutionary histories, ecological niches and reproductive strategies. In vitro …

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Spike Resonance Properties In Hippocampal O-Lm Cells Are Dependent On Refractory Dynamics., Kispersky Tj, Fernandez Fr, Economo Mn, White Ja Mar 2012

Spike Resonance Properties In Hippocampal O-Lm Cells Are Dependent On Refractory Dynamics., Kispersky Tj, Fernandez Fr, Economo Mn, White Ja

Faculty Publications

No abstract provided.

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Impact Of The Red Imported Fire Ant, Solenopsis Invicta (Hymenoptera: Formicidae), On Biological Control Of Salvinia Minima (Hydropteridales: Salviniaceae) By Cyrtobagous Salviniae (Coleoptera: Curculionidae), Katherine A. Parys, Seth J. Johnson Mar 2012

Impact Of The Red Imported Fire Ant, Solenopsis Invicta (Hymenoptera: Formicidae), On Biological Control Of Salvinia Minima (Hydropteridales: Salviniaceae) By Cyrtobagous Salviniae (Coleoptera: Curculionidae), Katherine A. Parys, Seth J. Johnson

Faculty Publications

A 2-yr study of the impacts of the red imported fire ant, Solenopsis invicta Buren, on the success of Cyrtobagous salviniae Calder & Sands as a biological control agent of common salvinia, Salvinia minima Baker, was undertaken in southern Louisiana. Floating moats were constructed around 8 release sites where C. salviniae was introduced as a biological control agent. These moats were used to restrict access to the release site by red imported fire ants in half the quadrats. Moating was successful in limiting the number of red imported fire ants in the release sites over the course of the study …

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Pathogen Persistence In The Environment And Insect-Baculovirus Interactions: Disease-Density Thresholds, Epidemic Burnout, And Insect Outbreaks, Emma Fuller, Bret D. Elderd, Greg Dwyer Mar 2012

Pathogen Persistence In The Environment And Insect-Baculovirus Interactions: Disease-Density Thresholds, Epidemic Burnout, And Insect Outbreaks, Emma Fuller, Bret D. Elderd, Greg Dwyer

Faculty Publications

Classical epidemic theory focuses on directly transmitted pathogens, but many pathogens are instead transmitted when hosts encounter infectious particles. Theory has shown that for such diseases pathogen persistence time in the environment can strongly affect disease dynamics, but estimates of persistence time, and consequently tests of the theory, are extremely rare. We consider the consequences of persistence time for the dynamics of the gypsy moth baculovirus, a pathogen transmitted when larvae consume foliage contaminated with particles released from infectious cadavers. Using field-transmission experiments, we are able to estimate persistence time under natural conditions, and inserting our estimates into a standard …

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Life, Transferable: Questioning The Commodity-Based Approach To Transplantation Ethics, David Dillard-Wright Mar 2012

Life, Transferable: Questioning The Commodity-Based Approach To Transplantation Ethics, David Dillard-Wright

Faculty Publications

Some bioethicists have proposed a legalized market in human organs as a solution to transplant waiting lists and global poverty. Solutions to organ procurement problems that are solely market-based would unfairly shift the burdens of medical procedures onto developing nations. Market advocates base their claims on the understanding of organs as property, a position that should be problematized. Instrumentalizing people in this way is made part of the broader commodification of animals and the environment. Combating the market mentality requires a return to the holistic view of bioethics that led to the founding of the field.

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Tolerance, Fermentation, And Cytokine Expression In Healthy Aged Male C57bl/6j Mice Fed Resistant Starch, June Zhou, Michael J. Keenan, Jeffrey Keller, Sun O. Fernandez-Kim, Paul J. Pistell, Richard T. Tulley, Anne M. Raggio, Li Shen, Hanjie Zhang, Roy J. Martin, Marc R. Blackman Mar 2012

Tolerance, Fermentation, And Cytokine Expression In Healthy Aged Male C57bl/6j Mice Fed Resistant Starch, June Zhou, Michael J. Keenan, Jeffrey Keller, Sun O. Fernandez-Kim, Paul J. Pistell, Richard T. Tulley, Anne M. Raggio, Li Shen, Hanjie Zhang, Roy J. Martin, Marc R. Blackman

Faculty Publications

Health benefits of resistant starch (RS), a dietary fermentable fiber, have been well documented in young, but not in old populations. As the essential step of more comprehensive evaluations of RS on healthy aging, we examined the effects of dietary RS on tolerance, colonic fermentation, and cytokine expression in aged mice. Healthy older (18-20 months) C57BL/6J male mice were fed control, 18% RS, or 36% RS diets for 10weeks. Body weight gain, body composition, and fat pad weights did not differ among the three groups after 10weeks, indicating good tolerance of the RS diet. Fermentation indicators (cecum weights, and cecal …

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“Done In Convention”: The Attestation Clause And The Declaration Of Independence, Jesse M. Cross Mar 2012

“Done In Convention”: The Attestation Clause And The Declaration Of Independence, Jesse M. Cross

Faculty Publications

No abstract provided.

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Normal Modes Of The Indian Elephant Bell, Robert Perrin, Luke Chalmers, Daniel Elford, Gerry M. Swallowe, Thomas R. Moore Mar 2012

Normal Modes Of The Indian Elephant Bell, Robert Perrin, Luke Chalmers, Daniel Elford, Gerry M. Swallowe, Thomas R. Moore

Faculty Publications

The geometrical structure of the Indian elephant bell is presented and the requirements on its normal modes from group representation theory are described. These are in good agreement with the results of a finiteelement model (FEM) for a specific 16-tine case. The spectrum consists of a sequence of families of modes lying on saturation curves and so is completely different from those of conventional bells. Physical explanations for the occurrence of these families are presented in terms of the tines behaving as a closed loop of coupled cantilevers with constraints from the dome. Each family is found to consist of …

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Particle Transport Over Rough Hillslope Surfaces By Dry Ravel: Experiments And Simulations With Implications For Nonlocal Sediment Flux, Emmanuel Gabet, Morgan Mendoza Feb 2012

Particle Transport Over Rough Hillslope Surfaces By Dry Ravel: Experiments And Simulations With Implications For Nonlocal Sediment Flux, Emmanuel Gabet, Morgan Mendoza

Faculty Publications

Past studies of hillslope evolution have typically assumed that soil creep processes are governed by a linear relationship between local hillslope angle and transport distance. The assumption of “linear diffusion” has fallen out of favor because, when coupled with an expression of mass continuity, it yields unrealistic hillslope profiles. As a consequence, a better understanding of the mechanics of sediment transport is needed. Here we report results from a series of flume experiments performed to investigate sediment transport by dry ravel, a common soil creep process in arid and semiarid environments. We find that, at gentle slopes, transport distances follow …

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Mapview And Cross Section Animations, Jason Luke Feb 2012

Mapview And Cross Section Animations, Jason Luke

Faculty Publications

Movie 1: A series of time slices animated through the amplitude volume. Movie 2: A series of time slices animated through the semblance volume. Movie 3: Cross section animation from SW-NE through the amplitude volume. Movie 4: Cross section animation from SW-NE through the semblance volume.

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Inactivation Of Androgen-Induced Regulator Ard1 Inhibits Androgen Receptor Acetylation And Prostate Tumorigenesis, Zehua Wang, Zemin Wang, Jianhui Guo, Yingchun Li, Jasmin H. Bavarva, Chiping Qian, M. Christiane Brahimi-Horn, Deyong Tan, Wanguo Liu Feb 2012

Inactivation Of Androgen-Induced Regulator Ard1 Inhibits Androgen Receptor Acetylation And Prostate Tumorigenesis, Zehua Wang, Zemin Wang, Jianhui Guo, Yingchun Li, Jasmin H. Bavarva, Chiping Qian, M. Christiane Brahimi-Horn, Deyong Tan, Wanguo Liu

Faculty Publications

Androgen signaling through androgen receptor (AR) is critical for prostate tumorigenesis. Given that AR-mediated gene regulation is enhanced by AR coregulators, inactivation of those coregulators is emerging as a promising therapy for prostate cancer (PCa). Here, weshowthat the N-acetyltransferase arrest-defect 1 protein (ARD1) functions as a unique AR regulator in PCa cells. ARD1 is up-regulated in human PCa cell lines and primary tumor biopsies. The expression of ARD1 was augmented by treatment with synthetic androgen (R1881) unless AR is deficient or is inhibited by AR-specific siRNA or androgen inhibitor bicalutamide (Casodex). Depletion of ARD1 by shRNA suppressed PCa cell proliferation, …

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Of Frightened Horses And Autonomous Vehicles: Tort Law And Its Assimilation Of Innovations, Kyle Graham Feb 2012

Of Frightened Horses And Autonomous Vehicles: Tort Law And Its Assimilation Of Innovations, Kyle Graham

Faculty Publications

This symposium contribution considers five recurring themes in the application of tort law to new technologies. First, the initial batch of cases presented to courts may be atypical of later lawsuits that implicate the innovation, yet relate rules with surprising persistence. Second, these cases may be identified, and resolved, by reference to analogies that rely on similarities in form, and which do not wear well over time. Third, it may be difficult to isolate the unreasonable risks generated by an innovation from the benefits it is perceived to offer. Fourth, potential claims by early adopters of the technology may be …

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