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Polypeptoid Polymers: Synthesis, Characterization, And Properties, Brandon A. Chan, Sunting Xuan, Ang Li, Jessica M. Simpson, Garrett L. Sternhagen, Tianyi Yu, Omead A. Darvish, Naisheng Jiang, Donghui Zhang Jan 2018

Polypeptoid Polymers: Synthesis, Characterization, And Properties, Brandon A. Chan, Sunting Xuan, Ang Li, Jessica M. Simpson, Garrett L. Sternhagen, Tianyi Yu, Omead A. Darvish, Naisheng Jiang, Donghui Zhang

Faculty Publications

© 2017 Wiley Periodicals, Inc. Polypeptoids, a class of peptidomimetic polymers, have emerged at the forefront of macromolecular and supramolecular science and engineering as the technological relevance of these polymers continues to be demonstrated. The chemical and structural diversity of polypeptoids have enabled access to and adjustment of a variety of physicochemical and biological properties (eg, solubility, charge characteristics, chain conformation, HLB, thermal processability, degradability, cytotoxicity and immunogenicity). These attributes have made this synthetic polymer platform a potential candidate for various biomedical and biotechnological applications. This review will provide an overview of recent development in synthetic methods to access polypeptoid …

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Expression Of An 8r-Lipoxygenase From The Coral Plexaura Homomalla, Nathaniel C. Gilbert, David B. Neau, Marcia E. Newcomer Jan 2018

Expression Of An 8r-Lipoxygenase From The Coral Plexaura Homomalla, Nathaniel C. Gilbert, David B. Neau, Marcia E. Newcomer

Faculty Publications

© 2018 Elsevier Inc. Methods are presented for the use of the coral 8R-lipoxygenase from the Caribbean sea whip coral Plexaura homomalla as a model enzyme for structural studies of animal lipoxygenases. The 8R-lipoxygenase is remarkably stable and can be stored at 4°C for 3 months with virtually no loss of activity. In addition, an engineered “pseudo wild-type” enzyme is soluble in the absence of detergents, which helps facilitate the preparation of enzyme:substrate complexes.

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Trpc5 Is Required For The No-Dependent Increase In Dendritic Ca 2+ And Gaba Release From Chick Retinal Amacrine Cells, J. Wesley Maddox, Nikka Khorsandi, Evanna Gleason Jan 2018

Trpc5 Is Required For The No-Dependent Increase In Dendritic Ca 2+ And Gaba Release From Chick Retinal Amacrine Cells, J. Wesley Maddox, Nikka Khorsandi, Evanna Gleason

Faculty Publications

© 2018 American Physiological Society. All rights reserved. GABAergic signaling from amacrine cells (ACs) is a fundamental aspect of visual signal processing in the inner retina. We have previously shown that nitric oxide (NO) can elicit release of GABA independently from activation of voltage-gated Ca 2+ channels in cultured retinal ACs. This voltage-independent quantal GABA release relies on a Ca 2+ influx mechanism with pharmacological characteristics consistent with the involvement of the transient receptor potential canonical (TRPC) channels TRPC4 and/or TRPC5. To determine the identity of these channels, we evaluated the ability of NO to elevate dendritic Ca 2+ and …

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Nkg2d Regulation Of Lung Pathology And Dendritic Cell Function Following Respiratory Syncytial Virus Infection, Huan Liu, Andrew R. Osterburg, Jennifer Flury, Shuo Huang, Francis X. Mccormack, Stephania A. Cormier, Michael T. Borchers Jan 2018

Nkg2d Regulation Of Lung Pathology And Dendritic Cell Function Following Respiratory Syncytial Virus Infection, Huan Liu, Andrew R. Osterburg, Jennifer Flury, Shuo Huang, Francis X. Mccormack, Stephania A. Cormier, Michael T. Borchers

Faculty Publications

© The Author(s) 2018. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. Background. Respiratory syncytial virus (RSV) is a common cause of respiratory tract infection in vulnerable populations. Natural killer (NK) cells and dendritic cells (DC) are important for the effector functions of both cell types following infection. Methods. Wild-type and NKG2D-deficient mice were infected with RSV. Lung pathology was assessed by histology. Dendritic cell function and phenotype were evaluated by enzyme-linked immunosorbent assay and flow cytometry. The expression of NKG2D ligands on lung and lymph node DCs was measured by immunostaining and …

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Intergenic And Intronic Dna Hypomethylated Regions As Putative Regulators Of Imprinted Domains, Arundhati Bakshi, Corey L. Bretz, Terri L. Cain, Joomyeong Kim Jan 2018

Intergenic And Intronic Dna Hypomethylated Regions As Putative Regulators Of Imprinted Domains, Arundhati Bakshi, Corey L. Bretz, Terri L. Cain, Joomyeong Kim

Faculty Publications

© 2018 2018 Future Medicine Ltd. Aim: To investigate the regulatory potential of intergenic/intronic hypomethylated regions (iHMRs) within imprinted domains. Materials & methods: Based on the preliminary results of the histone modification and conservation profiles, we conducted reporter assays on the Peg3 and H19 domain iHMRs. The in vitro results were confirmed by the in vivo deletion of Peg3-iHMR designed to test its function in the Peg3 imprinted domain. Results & conclusion: Initial bioinformatic analyses suggested that some iHMRs may be noncanonical enhancers for imprinted genes. Consistent with this, Peg3- and H19-iHMRs showed context-dependent promoter and enhancer activity. Further, deletion …

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Field And Laboratory Studies On The Ecology, Reproduction, And Adult Diapause Of The Asian Comma Butterfly, Polygonia C-Aureum L. (Lepidoptera: Nymphalidae), Satoshi Hiroyoshi, Gadi V.P. Reddy Jan 2018

Field And Laboratory Studies On The Ecology, Reproduction, And Adult Diapause Of The Asian Comma Butterfly, Polygonia C-Aureum L. (Lepidoptera: Nymphalidae), Satoshi Hiroyoshi, Gadi V.P. Reddy

Faculty Publications

Adult diapause and reproduction of a nymphalid butterfly, Polygonia c-aureum L., were investigated in field and laboratory examinations. Laboratory studies showed that old virgin male butterflies of non-diapausing generations had heavy accessory glands and simplex, which were suppressed in diapausing generations. The number of eupyrene sperm bundles in the duplex increased with adult age, whereas testis size decreased with age. Field examinations indicated that reproductive development of both sexes of diapausing generations in autumn was suppressed, and developed in spring. We attempted to estimate the physiological age of wild-caught males, as adult male age can be estimated from the testis …

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Recognizing The Danger Zone: Response Of Female White-Tailed To Discrete Hunting Events, Jeffery D. Sullivan, Stephen S. Ditchkoff, Bret A. Collier, Charles R. Ruth, Joshua B. Raglin Jan 2018

Recognizing The Danger Zone: Response Of Female White-Tailed To Discrete Hunting Events, Jeffery D. Sullivan, Stephen S. Ditchkoff, Bret A. Collier, Charles R. Ruth, Joshua B. Raglin

Faculty Publications

The landscape of fear theory proposes that prey should utilize habitat over space and time such that demographic risk is minimized. White-Tailed deer Odocoileus virginianus respond to temporally and spatially predictable threats posed by humans consistent with the landscape of fear theory. However, few studies examining the response of deer to hunting have accounted for the localized nature of risk. To determine if white-Tailed deer are able to recognize and respond to risks posed by hunters relative to specific hunting locations, we equipped 38 female white-Tailed deer with GPS collars August-December 2013-2015. Deer were generally found to increase use of …

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Looking At The Big Picture: Understanding How The Oviduct's Dialogue With Gametes And The Embryo Shapes Reproductive Success, Beatriz Fernandez-Fuertes, Beatriz Rodríguez-Alonso, José María Sánchez, Constantine A. Simintiras, Patrick Lonergan, Dimitrios Rizos Jan 2018

Looking At The Big Picture: Understanding How The Oviduct's Dialogue With Gametes And The Embryo Shapes Reproductive Success, Beatriz Fernandez-Fuertes, Beatriz Rodríguez-Alonso, José María Sánchez, Constantine A. Simintiras, Patrick Lonergan, Dimitrios Rizos

Faculty Publications

The oviduct is a tubular organ comprising three distinct anatomical regions (the infundibulum, the ampulla and the isthmus) connecting the ovary and the uterus. Oviductal function is regulated by ovarian hormones, gametes, and embryo-derived factors, for optimally facilitating key reproductive events. A cross-talk is established between the oviduct and the gametes and embryo and this dialogue shapes the microenvironment in which gamete transport, fertilization, and early embryonic development occur. This review aims to address each participant in this conversation in a holistic manner by delineating several advances in the field within the greater context of understanding how oviduct-gamete and oviduct-embryo …

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Gluten-Free Bakery And Pasta Products: Prevalence And Quality Improvement, Yupeng Gao, Marlene E. Janes, Busarawan Chaiya, Margaret A. Brennan, Charles S. Brennan, Witoon Prinyawiwatkul Jan 2018

Gluten-Free Bakery And Pasta Products: Prevalence And Quality Improvement, Yupeng Gao, Marlene E. Janes, Busarawan Chaiya, Margaret A. Brennan, Charles S. Brennan, Witoon Prinyawiwatkul

Faculty Publications

An increasing demand of gluten-free (GF) products is caused by a growing number of diagnosed coeliacs and a consumption trend to eliminate allergenic proteins from diet. Driven by the rapidly growing market, comprehensive understanding of GF products is necessary. The purpose of this review was to concisely present an overview of various approaches to improve physicochemical and sensory qualities of GF bread, cake/muffin and pasta/noodle products. Some novel techniques used in GF products were discussed in this review. These techniques included the use of different alternative flours (including GF cereals, pseudo-cereals, legume flours, fruit and vegetable powders and seafood powders), …

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Investigating The Role Of Mitochondrial Respiratory Dysfunction During Hexavalent Chromium-Induced Lung Carcinogenesis, James T.F. Wise, Lei Wang, Michael C. Alstott, Ntube N.O. Ngalame, Yuting Wang, Zhuo Zhang, Xianglin Shi Jan 2018

Investigating The Role Of Mitochondrial Respiratory Dysfunction During Hexavalent Chromium-Induced Lung Carcinogenesis, James T.F. Wise, Lei Wang, Michael C. Alstott, Ntube N.O. Ngalame, Yuting Wang, Zhuo Zhang, Xianglin Shi

Faculty Publications

Hexavalent chromium [Cr(VI)] is a lung carcinogen and its complete mechanism of action remains to be investigated. Metabolic reprogramming of key energy metabolism pathways (e.g., increased anaerobic glycolysis in the presence of oxygen or “Warburg effect,” dysregulated mitochondrial function, and lipogenesis) are important to cancer cell and tumor survival and growth. In our current understanding of Cr(VI)-induced carcinogenesis, the role for metabolic reprogramming remains unclear. In this study, we treated human lung epithelial cells (BEAS-2B) with Cr(VI) for 6 months and obtained malignantly transformed cells from an isolated colony grown in soft agar. We also used Cr(VI)-transformed cells from two …

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Saltmarsh Plants, But Not Fertilizer, Facilitate Invertebrate Recolonization After An Oil Spill, David Samuel Johnson, John W. Fleeger, Maria Rita Riggio, Irving A. Mendelssohn, Qianxin Lin, Sean A. Graham, Donald R. Deis, Aixin Hou Jan 2018

Saltmarsh Plants, But Not Fertilizer, Facilitate Invertebrate Recolonization After An Oil Spill, David Samuel Johnson, John W. Fleeger, Maria Rita Riggio, Irving A. Mendelssohn, Qianxin Lin, Sean A. Graham, Donald R. Deis, Aixin Hou

Faculty Publications

Foundation species contribute to the recovery of animal communities from disturbance by engineering, by improving habitat quality, and by regulating food availability. In a salt marsh impacted by the Deepwater Horizon oil spill, we tested the hypothesis that nutrient subsidies would enhance the positive effects of the foundation species Spartina alterniflora on the initial recolonization of benthic invertebrate communities (e.g., copepods, annelids, nematodes) by augmenting food (i.e., microalgae) availability. After two months, plantings of S. alterniflora significantly elevated the densities of the polychaete Capitella capitata, meiofauna-sized annelids, and total macroinfauna over unplanted plots. After 7 months, the significant effect of …

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Schooling At Risk, Barbara A. Fedders Jan 2018

Schooling At Risk, Barbara A. Fedders

Faculty Publications

No abstract provided.

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Editing Nature: Reconceptualizing Biotechnology Governance, Jonas J. Monast Jan 2018

Editing Nature: Reconceptualizing Biotechnology Governance, Jonas J. Monast

Faculty Publications

No abstract provided.

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Sex And Religion: Unholy Bedfellows, Mary-Rose Papandrea Jan 2018

Sex And Religion: Unholy Bedfellows, Mary-Rose Papandrea

Faculty Publications

No abstract provided.

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Copyright Policy As Catalyst And Barrier To Innovation And Free Speech, Amanda Reid Jan 2018

Copyright Policy As Catalyst And Barrier To Innovation And Free Speech, Amanda Reid

Faculty Publications

No abstract provided.

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Whether Or Not Special Expertise Is Needed: Anti-Intellectualism, The Supreme Court, And The Legitimacy Of Law, Sean Kammer Jan 2018

Whether Or Not Special Expertise Is Needed: Anti-Intellectualism, The Supreme Court, And The Legitimacy Of Law, Sean Kammer

Faculty Publications

No abstract provided.

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Health Information Programming In Public Libraries: A Content Analysis, Lili Luo Jan 2018

Health Information Programming In Public Libraries: A Content Analysis, Lili Luo

Faculty Publications

Health information programs, defined as library programs focusing on health-related topics, are an essential way for public libraries to reach out to their user communities, raising awareness of and interest in healthy lifestyle, promoting access to quality health information, and ultimately enhancing health literacy of the citizenry. This study presents a content analysis of the health information programs provided by a large urban public library system in the past year, seeking to strengthen the professional understanding of how public libraries can contribute to health literacy improvement through effective programming, and help other libraries gain insights on health information program planning …

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The Law Of Social Entrepreneurship – Creating Shared Value Through The Lens Of Sandra Day O’Connor’S Icivics, Anat Alon-Beck Jan 2018

The Law Of Social Entrepreneurship – Creating Shared Value Through The Lens Of Sandra Day O’Connor’S Icivics, Anat Alon-Beck

Faculty Publications

This article calls for harmonizing state law legislation on social enterprises, due to the potential discrepancy between the various states on the nature and legal structure of social enterprises. Since 2008, legislators in thirty-five (35) states across the United States of America and the District of Columbia, have enacted some form of innovative social enterprise legislation. This new revolution in corporate law is called social entrepreneurship, mirroring social movements in the aftermath of the 2008 financial crisis. Public opinion has led to a shift in prevalent corporate governance theory, from current share-holder centric corporate governance to collaborative corporate governance. A …

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Development And Validation Of The Outdoor Activity Profile (Oap): A Research Note, Andrew Lacanienta, Mat Duerden, Peter Ward, Ramon Zabriskie Jan 2018

Development And Validation Of The Outdoor Activity Profile (Oap): A Research Note, Andrew Lacanienta, Mat Duerden, Peter Ward, Ramon Zabriskie

Faculty Publications

This study sought to design and validate the Outdoor Activity Profile (OAP), which was based on the Family Leisure Activity Profile (FLAP; Zabriskie & McCormick, 2001). The OAP was designed to measure and categorize involvement as opposed to time in outdoor activities. Data were collected from undergraduate students on two occasions separated by four weeks. Significant correlations existed between all time one and time two involvement scores, thereby supporting the OAP’s test-retest reliability. Descriptive data is presented outlining involvement, satisfaction, and whom respondents were with during activity categories. One-way ANOVA results describe differences between male and female outdoor activity involvement …

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Joint Dedication To Justice Lori S. Wilbur, Neil Fulton Jan 2018

Joint Dedication To Justice Lori S. Wilbur, Neil Fulton

Faculty Publications

No abstract provided.

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Narrating Contested Pasts: Lessons Learned At Tall Hesban, Oystein S. Labianca, Elena Maria Ronza Jan 2018

Narrating Contested Pasts: Lessons Learned At Tall Hesban, Oystein S. Labianca, Elena Maria Ronza

Faculty Publications

No abstract provided.

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Tall Hisban 2016 Expedition Season: Household Archaeology In The Medieval Village, Bethany Walker, Tarina Greer, Reem Al-Shqour, Aren Labianca, Robert D. Bates, Jeffrey P. Hudon, Warren Schultz, Julian Henderson, Chiara Corbino, Sofia Laparidou, Annette Hansen, Oystein Labianca Jan 2018

Tall Hisban 2016 Expedition Season: Household Archaeology In The Medieval Village, Bethany Walker, Tarina Greer, Reem Al-Shqour, Aren Labianca, Robert D. Bates, Jeffrey P. Hudon, Warren Schultz, Julian Henderson, Chiara Corbino, Sofia Laparidou, Annette Hansen, Oystein Labianca

Faculty Publications

No abstract provided.

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Licensing & Law Who Owns An Avatar?, Tyler T. Ochoa, Jaime Banks Jan 2018

Licensing & Law Who Owns An Avatar?, Tyler T. Ochoa, Jaime Banks

Faculty Publications

Both players and game developers have great influence over how avatars—via their assembled components— manifest in digital game play. Developers craft their foundational platforms and draw on those infrastructures to craft dynamic code that enables movements, appearances, and abilities. But those potentials call into question whether avatars are avatars until they are played—players click avatars into being, customize their bodies and attire, drive their actions and interactions, and sometimes bring them outside the game world through physical representations. So, given avatars’ joint reliance on developers and players, and given legal frameworks such as copyright law, who really “owns” a video …

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Inequality, Innovation, And Patents, Colleen V. Chien Jan 2018

Inequality, Innovation, And Patents, Colleen V. Chien

Faculty Publications

This article explores the relationship between patents, innovation, and inequality, making three contributions. First, it reveals how shifts in patented innovation over the last several decades have contributed to broader social and economic shifts, away from manufacturing-based, domestic, and independent innovation, and towards digital, foreign, and corporate innovation, validating both optimistic accounts of immigration-driven, digital prosperity and pessimistic accounts of the shrinking role of domestic innovators. Second, it offers a framework for understanding the relationship between innovation and inequality that includes both the potentially inequality-increasing impacts of innovation and the potentially inequality-decreasing impacts of innovation and specifies the contribution of …

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Hydrothermal Carbonization: Modeling, Final Properties Design And Applications: A Review, Silvia Román, Judy Libra, Nicole Berge, Eduardo Sabio, Kyoung Ro, Liang Li, Beatriz Ledesma, Andrés Alvarez, Sunyoung Bae Jan 2018

Hydrothermal Carbonization: Modeling, Final Properties Design And Applications: A Review, Silvia Román, Judy Libra, Nicole Berge, Eduardo Sabio, Kyoung Ro, Liang Li, Beatriz Ledesma, Andrés Alvarez, Sunyoung Bae

Faculty Publications

Active research on biomass hydrothermal carbonization (HTC) continues to demonstrate its advantages over other thermochemical processes, in particular the interesting benefits that are associated with carbonaceous solid products, called hydrochar (HC). The areas of applications of HC range from biofuel to doped porous material for adsorption, energy storage, and catalysis. At the same time, intensive research has been aimed at better elucidating the process mechanisms and kinetics, and how the experimental variables (temperature, time, biomass load, feedstock composition, as well as their interactions) affect the distribution between phases and their composition. This review provides an analysis of the state of …

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The Expansion Of Child Pornography Law, Carissa Byrne Hessick Jan 2018

The Expansion Of Child Pornography Law, Carissa Byrne Hessick

Faculty Publications

This Symposium essay identifies two dramatic expansions of child pornography law: prosecutions for possessing images of children who are clothed and not engaged in any sexual activity, and prosecutions for possessing smaller portions of artistic and non-pornographic images. These prosecutions have expanded the definition of the term ‘‘child pornography’’ well beyond its initial meaning. What is more, they signal that child pornography laws are being used to punish people not necessarily because of the nature of the picture they possess, but rather because of the conclusion that those individuals are sexually attracted to children. If law enforcement concludes that a …

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Fractality Of Body Movements Predicts Perception Of Affordances: Evidence From Stand-On-Ability Judgments About Slopes, Alen Hajnal, Joseph Clark, Jonathan K. Doyon, Damian G. Kelty-Stephen Jan 2018

Fractality Of Body Movements Predicts Perception Of Affordances: Evidence From Stand-On-Ability Judgments About Slopes, Alen Hajnal, Joseph Clark, Jonathan K. Doyon, Damian G. Kelty-Stephen

Faculty Publications

We recorded head motion with one wireless marker attached to the back of the head during quiet stance as participants visually inspected a sloped ramp in order to perceive whether they might be able to stand on the surface. Participants responded with "yes" or "no" without attempting to stand on the ramp. As has been found in dynamic touch (Palatinus, Kelty-Stephen, Kinsella-Shaw, Carello, & Turvey, 2014), we hypothesized that multiscale fluctuation patterns in bodily movement during visual observation would predict perceptual judgments. Mixed-effects logistic regression predicted binary affordance judgments as a function of geographical slant angle, head-motion standar deviation, and …

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A Will For Willa Cather, Thomas Simmons Jan 2018

A Will For Willa Cather, Thomas Simmons

Faculty Publications

Artists hold their creative works dear. Whether paintings, poems, or songs, their human creators treat them with special care and often desire that same care be exercised after death. Some may wish to ban the use of a song in a television commercial. Others may wish to stop their novel from being turned into an animated Disney movie. But directing particular uses of property from the grave can be met with several objections and legal impediments. The objections sound in alarmist responses to “dead hand control.” The impediments include the Rule Against Perpetuities, uncertainty, capriciousness, and the repugnancy of restraints …

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The Humanities: Our Human Journey, Ilona Klein Jan 2018

The Humanities: Our Human Journey, Ilona Klein

Faculty Publications

Life. The miracle of human life. Scientists believe that our incarnation as anatomically modern humans–homo sapiens–began on African soil about 200,000 years ago, as we started walking erect on two legs instead of four. We wandered upon our planet, a tiny, beautiful, blueish speck almost literally in the middle of nowhere, traveling elliptically around our sun within the cold, dark immensity of the universe.

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Informational Video Gaming In The Waiting Room, Andrew Long, Mitchell Ramirez, Coltin Shields, Nathan Twyman Jan 2018

Informational Video Gaming In The Waiting Room, Andrew Long, Mitchell Ramirez, Coltin Shields, Nathan Twyman

Faculty Publications

This study is testing the potential of a gamified method of conveying information and the ability of the game to influence people’s sentiment towards immunization. The most popular way that medical information and awareness is spread is in the form of pamphlets or flyers, even though many people either ignore them or do not retain much information from them. Perhaps a game paired with intermittent quiz questions that influence the overall score will improve overall retention as compared with plain reading. To test this hypothesis, a game was designed to include identical information as a pamphlet commonly handed out in …

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