Digital Commons Network^™

Transcriptomic Analysis Reveals That Municipal Wastewater Effluent Enhances Vibrio Vulnificus Growth And Virulence Potential, Karlen Enid Correa Velez, Robert Sean Norman

Faculty Publications

Vibrio vulnificusis an opportunistic pathogen indigenous to estuarine and marine environments and associated with aquatic organisms. Vibrio vulnificusis of utmost importance because it causes 95% of the seafood-related deaths in the United States due to rapid progression of septicemia. Changes in environmental parameters associated with climate change and coastal population expansion are altering geographical constraints, resulting in increased Vibrio spread, exposure, and rates of infection. In addition, coastal population expansion is resulting in increased input of treated municipal sewage into areas that are also experiencing increased Vibrio proliferation. This study aimed to better understand the influence of treated …

Occurrence And Removal Of Engineered Nanoparticles In Drinking Water Treatment And Wastewater Treatment A Review, Cheng Yu, Sewoon Kim, Min Jang, Chang Min Park, Yeomin Yoon

Faculty Publications

Engineered nanoparticles (ENPs) are widely used in various industrial products and consumer goods, resulting in their widespread existence, particularly in natural water systems and water and wastewater treatment plants. Their presence in surface water for human consumption may severely harm human health. Therefore, this review examines new findings and developments in the removal technology of ENPs in drinking water and wastewater treatment processes since the publication of the literature by Park et al. [1]. By evaluating recent articles, this review investigates the occurrence of ENPs, discusses the transport of nanoparticles (NPs) in various drinking water and wastewater treatment …

Cytotoxicity Analysis Of Pre- And Post-Hurricane Harvey Soil Samples Collected From Greater Houston Bayous, Djene Keita, Shishir Shishodia, Balaji Bhaskar Maruthi Sridhar

Faculty Publications

Rapid urbanization, anthropogenic pollution and frequent flooding events are affecting the soil and water quality along the streams and bayous of Houston. Soil acts as sink and reservoir of heavy metals and nutrients affecting human and animal health. The objectives of the study are 1) to analyze the effects of the metal and nutrient concentration of bayou flood plain surface soil samples on the gut cell cytotoxicity and 2) to evaluate the spatial and temporal difference in soil contamination on cell viability of colon cancer (HT-29) and normal colon epithelial (CCD 841 CoN) cell lines. To evaluate soil contamination between …

Binary And Ternary Toxicological Interactions Of Clothianidin And Eight Commonly Used Pesticides On Honey Bees (Apis Mellifera), Yanhua Wang, Yu Cheng Zhu, Wenhong Li, Jianxiu Yao, Gadi V.P. Reddy, Lu Lv

Faculty Publications

Although many toxicological evaluations have been conducted for honey bees (Apis mellifera), most of these studies have only focused on the effects of individual chemicals. However, honey bees are usually exposed to pesticide mixtures under field conditions. In this study, we examined the effects of individual pesticides and mixtures of clothianidin (CLO) with eight other pesticides [carbaryl (CAR), thiodicarb (THI), chlorpyrifos (CHL), beta-cyfluthrin (BCY), gamma-cyhalothrin (GCY), tetraconazole (TET), spinosad (SPI) and indoxacarb (IND)] on honey bees using a feeding method. Toxicity tests of a 4-day exposure to individual pesticides revealed that CLO had the highest toxicity to A. mellifera, with …

Voice-Activated Virtual Home Assistant Use And Social Isolation And Loneliness Among Older Adults: Mini Review, Cynthia F. Corbett, Pamela J. Wright Phd, Ms, Med, Rn, Cen, Kate Jones, Michael Parmer

Faculty Publications

A lack of social connectedness is common among older adults due to living alone, loss of loved ones, reduced mobility, and, more recently, social distancing created by the global Covid-19 pandemic. Older adults are vulnerable to social isolation and loneliness, which pose significant health risks comparable to those of smoking, obesity, physical inactivity, and high blood pressure. A lack of social connectedness is also correlated with higher mortality rates even when controlling for other factors such as age and comorbid conditions. The purpose of this mini review was to explore the emerging concepts of older adults' use of commercially available …

Framing Of And Attention To Covid-19 On Twitter: Thematic Analysis Of Hashtags, Iman Tahamtan, Devendra Potnis, Ehsan Mohammadi, Laura E. Miller, Vandana Singh

Faculty Publications

Background: Although past research has focused on COVID-19–related frames in the news media, such research may not accurately capture and represent the perspectives of people from diverse backgrounds. Additionally, research on the public attention to COVID-19 as reflected through frames on social media is scarce.

Objective: This study identified the frames about the COVID-19 pandemic in the public discourse on Twitter, which voices diverse opinions. This study also investigated the amount of public attention to those frames on Twitter.

Methods: We collected 22 trending hashtags related to COVID-19 in the United States and 694,582 tweets written in English containing these …

Trajectories Of Heart Activity Across Infancy To Early Childhood Differentially Predict Autism And Anxiety Symptoms In Fragile X Syndrome, Abigail Hogan Ph.D., Erin Hunt, Kayla Smith, Conner Black, Katherine Bangert, Jessica Klusek Ph.D., Ccc-Slp, Jane Roberts

Faculty Publications

Fragile X syndrome (FXS) is a monogenic disorder characterized by high rates of autism spectrum disorder (ASD) and anxiety. A longstanding "hyperarousal hypothesis" in FXS has argued that ANS dysfunction underpins many symptoms of FXS. However, the developmental onset and trajectory of ANS dysfunction, as well as the consequences of ANS dysfunction on later psychiatric symptoms, remain poorly understood in FXS. Insight into the emergence, trajectory, and consequences of ANS dysfunction across early development in FXS has critical implications for prevention, intervention, and optimal outcomes in both typical and atypical development. This longitudinal study investigated whether and when males with …

Developing Nutritional Component Chrysin As A Therapeutic Agent: Bioavailability And Pharmacokinetics Consideration, And Adme Mechanisms, Song Gao, Nyma Siddiqui, Imoh Etim, Ting Du, Yun Zhang, Dong Liang

Faculty Publications

Chrysin is a promising naturally occurring flavonoid mainly found in honey and propolis. Although chrysin's biological activities have been demonstrated and the mechanism of actions has been determined using in vitro and in vivo models, results from the current clinical studies were largely negative. A potential reason for chrysin's low efficacy in humans is poor oral bioavailability. In this paper, we reviewed the preclinical and clinical pharmacokinetics studies of chrysin and analyzed the mechanism of poor in vivo efficacy with emphasis on its bioavailability and ADME mechanism. Low aqueous solubility, rapid metabolism mediated by UGTs and SULT, efficient excretion through …

The Therapeutic Potential Of The Novel Angiotensin-Converting Enzyme 2 In The Treatment Of Coronavirus Disease-19, Ademola Adetokunbo Oyagbemi, Temitayo Olabisi Ajibade, Yapo Guillaume Aboua, Idayat Titilayo Gbadamosi, Aduragbenro Deborah A. Adedapo, Abimbola Obemisola Aro, Olumuyiwa Abiola Adejumobi, Emma Thamahane-Katengua, Temidayo Olutayo Omobowale, Olufunke Olubunmi Falayi, Taiwo Olaide Oyagbemi, Blessing Seun Ogunpolu, Fasilat Oluwakemi Hassan, Iyanuoluwa Omolola Ogunmiluyi, Olufunke Eunice Ola-Davies, Adebowale Benard Saba, Adeolu Alex Adedapo, Sanah Malomile Nkadimeng, Lyndy Joy Mcgaw, Prudence Ngalula Kayoka-Kabongo, Momoh Audu Yakubu

Faculty Publications

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the etiological agent of coronavirus disease 2019 (COVID-19). This virus has become a global pandemic with unprecedented mortality and morbidity along with attendant financial and economic crises. Furthermore, COVID-19 can easily be transmitted regardless of religion, race, sex, or status. Globally, high hospitalization rates of COVID-19 patients have been reported, and billions of dollars have been spent to contain the pandemic. Angiotensin-converting enzyme (ACE) 2 is a receptor of SARS-CoV-2, which has a significant role in the entry of the virus into the host cell. ACE2 is highly expressed in the type …

Anticipating And Adapting To The Future Impacts Of Climate Change On The Health, Security And Welfare Of Low Elevation Coastal Zone (Lecz) Communities In Southeastern Usa, Thomas Allen, Joshua Behr, Anamaria Bukvic, Ryan S.D. Calder, Kiki Caruson, Charles Connor, Christopher D’Elia, David Dismukes, Robin Ersing

Faculty Publications

No abstract provided.

Democracy Avoidance In Tax Lawmaking, Clint G. Wallace

Faculty Publications

The Tax Cuts and Jobs Act was the most significant tax law in more than three decades, but the strategy for getting it enacted included a variety of maneuvers to avoid public scrutiny. As a result, many taxpayers did not know how they would be affected until they filed their own tax returns more than a year later. This Article identifies this lack of transparency as part of a persistent pathology of avoiding and constraining democratic inputs and responsiveness in U.S. federal tax lawmaking. Indeed, some scholars and policy makers have sought to channel tax lawmaking away from democratically grounded …

Reattribution, The Poison Pill And Inventorship, Dennis D. Crouch

Faculty Publications

Brian Frye's Right of Reattribution proposes a mechanism for loosening the strictures of attribution associated with creative works of authorship and giving the law of attribution a pro-property spin. Authors regularly receive attribution recognizing their authorship role. Frye transforms this norm of attribution into a fully alienable property right. An author would receive original rights of attribution, but those rights could then be sold or transferred to another person seeking accolades. This secondary transfer process is knows as reattribution. Frye recognizes that a right of reattribution would require congressional action since the current scope of attribution rights is limited by …

Placental Adaptation To Maternal Malnutrition, M. Carey Satterfield, Ashley K. Edwards, Fuller W. Bazer, Kathrin A. Dunlap, Chelsie B. Steinhauser, Guoyao Wu

Faculty Publications

Maternal malnutrition gives rise to both short- and long-term consequences for the survival and health of the offspring. As the intermediary between mother and fetus, the placenta has the potential to interpret environmental signals, such as nutrient availability, and adapt to support fetal growth and development. While this potential is present, it is clear that at times placental adaptation fails to occur resulting in poor pregnancy outcomes. This review will focus on placental responses to maternal undernutrition related to changes in placental vascularization and hemodynamics and placental nutrient transport systems across species. While much of the available literature describes placental …

Nest Survival Of Seaside Sparrows (Ammospiza Maritima) In The Wake Of The Deepwater Horizon Oil Spill, Megan E. Hart, Anna Perez-Umphrey, Philip C. Stouffer, Christine Bergeon Burns, Andrea Bonisoli-Alquati, Sabrina S. Taylor, Stefan Woltmann

Faculty Publications

In 2010, the Deepwater Horizon oil spill released an estimated 4.9 million barrels of oil into the Gulf of Mexico, damaging coastal ecosystems. Seaside Sparrows (Ammospiza maritima)—a year-round resident of Gulf Coast salt marshes—were exposed to oil, as shown by published isotopic and molecular analyses, but fitness consequences have not been clarified. We monitored nests around two bays in Plaquemines Parish, Louisiana, USA from 2012–2017 to assess possible impacts on the nesting biology of Seaside Sparrows. A majority of nests failed (76% of known-fate nests, N = 252 nests, 3521 exposure-days) during our study, and predation was the main cause …

Carcass Yields And Physical-Chemical Meat Quality Characteristics Of Namibian Red Hartebeest (Alcelaphus Buselaphus) As Influenced By Sex And Muscle, Louwrens C. Hoffman, Diana L. Van Schalkwyk, Magdalena Muller, Tersia Needham, Kenneth W. Mcmillin

Faculty Publications

This study determined the carcass yields of red hartebeest from Namibia and compared the physical-chemical meat quality characteristics of six different muscles (biceps femoris, infraspinatus, longissimus thoracis et lumborum, semimembranosus, semitendinosus, and supraspinatus) for both males and females. Red hartebeest males were heavier (133.92 kg) than females (114.20 kg) but the average dressing percentage did not differ between the two sexes. Muscles from females had a lower mean shear force value of 3.59 kg/1.27 cm ø, compared to males (4.23 kg/1.27 cm ø). The most tender muscle was the infraspinatus of the female treatment group, while the semimembranosus of the …

Atlas Of Receptor Genes Expressed By The Bovine Morula And Corresponding Ligand-Related Genes Expressed By Uterine Endometrium, Lei Sang, Yao Xiao, Zongliang Jiang, Niamh Forde, Xiuchun Cindy Tian, Patrick Lonergan, Peter J. Hansen

Faculty Publications

Regulation of the mammalian embryo involves cell-signaling molecules produced by the maternal oviduct and endometrium. Here, datasets on the transcriptome of the gestational Days 5 and 6 bovine morula and Day 5 maternal endometrium were examined to identify receptor genes expressed by the morula and expression of the corresponding ligand-related genes in the endometrium. A total of 175 receptor genes were identified in the morula, including 48 encoding for growth factors or WNT signaling molecules, 25 for cytokines and chemokines, 35 involved in juxtacrine and matricellular signaling and 25 encoding for receptors for small molecules. Some of the highly-expressed pairs …

Bigger, Better, Wider, And Always More: What Has Wealth To Do With Mission?, Gerald A. Klingbeil

Faculty Publications

No abstract provided.

Sperm Repository For A Breeding Program Of The Eastern Oyster Crassostrea Virginica: Sample Collection, Processing, Cryopreservation, And Data Management Plan, Huiping Yang, Yuanzi Huo, Jayme C. Yee, Scott Rikard, William C. Walton, Eric A. Saillant

Faculty Publications

The Eastern oyster Crassostrea virginica (Family Ostreidae) is one of the most important fishery and aquaculture species in the U.S. and is a keystone species for coastal reefs. A breeding program was initiated in 2019 to support the fast-growing aquaculture industry culturing this species in the Gulf of Mexico. Oysters from 17 wild populations in embayment along the U.S. Gulf of Mexico coast from southwest Florida to the Matagorda Bay, Texas were used as broodstock for the program to maximize genetic diversity in the base population. A sperm repository of the broodstock was established to support the breeding project. The …

Enhanced Detection Of Desmoplasia By Targeted Delivery Of Iron Oxide Nanoparticles To The Tumour-Specific Extracellular Matrix, Meenu Chopra, Jiansha Wu, Yen Ling Yeow, Louise Winteringham, Tristan D. Clemons, Martin Saunders, Venkata Ramana Kotamraju, Ruth Ganss, Kirk W. Feindel, Juliana Hamzah

Faculty Publications

Diagnostic imaging of aggressive cancer with a high stroma content may benefit from the use of imaging contrast agents targeted with peptides that have high binding affinity to the extracellular matrix (ECM). In this study, we report the use of superparamagnetic iron-oxide nanoparticles (IO-NP) conjugated to a nonapeptide, CSGRRSSKC (CSG), which specifically binds to the laminin-nidogen-1 complex in tumours. We show that CSG-IO-NP accumulate in tumours, predominantly in the tumour ECM, following intravenous injection into a murine model of pancreatic neuroendocrine tumour (PNET). In contrast, a control untargeted IO-NP consistently show poor tumour uptake, and IO-NP conjugated to a pentapeptide. …

Preaching Social Justice, Hyveth Williams

Faculty Publications

No abstract provided.

Coronary Heart Disease (Chd) In Elderly Patients: Which Drug To Choose, Ticagrelor And Clopidogrel? A Systematic Review And Meta-Analysis Of Randomized Controlled Trials, Mohammed Ahmed Akkaif, Abubakar Sha'aban, Nur Aizati Athirah Daud, Ismaeel Yunusa Ph.D., Mei Li Ng, Muhamad Ali Sk Abdul Kader, Dzul Azri Mohamed Noor, Baharudin Ibrahim

Faculty Publications

Background: A new generation P2Y12 receptor inhibitor (ticagrelor) is recommended in current therapeutic guidelines to treat patients with coronary heart disease (CHD). However, it is unknown if ticagrelor is more effective than clopidogrel in elderly patients. Therefore, a systematic review was done to assess the effectiveness and safety of ticagrelor and clopidogrel in older patients with CHD to determine the appropriate antiplatelet treatment plan. Methodology: We performed a systematic review of randomized controlled trials (RCTs) to compare the effectiveness and safety of ticagrelor vs. clopidogrel in elderly patients with CHD. We selected eligible RCTs based on specified study criteria following …

Analysis Of Body Condition Indices Reveals Different Ecotypes Of The Antillean Manatee, D. N. Castelblanco-Martínez, D. H. Slone, S. S. Landeo-Yauri, E. A. Ramos, A. Alvarez-Alemán, F. L. N. Attademo, C. A. Beck, R. K. Bonde, S. M. Butler, L. J. Cabrias-Contreras, D. Caicedo-Herrera, J. Galves, I. V. Gómez-Camelo, Daniel Gonzalez-Socoloske, J. Jiménez-Domínguez, F. O. Luna, Y. Mona-Sanabria, J. B. Morales-Vela, L. D. Olivera-Gómez, J. A. Padilla-Saldívar, J. Powell, J. P. Reid, G. Rieucau, A. A. Mignucci-Giannoni

Faculty Publications

Assessing the body condition of wild animals is necessary to monitor the health of the population and is critical to defining a framework for conservation actions. Body condition indices (BCIs) are a non-invasive and relatively simple means to assess the health of individual animals, useful for addressing a wide variety of ecological, behavioral, and management questions. The Antillean manatee (Trichechus manatus manatus) is an endangered subspecies of the West Indian manatee, facing a wide variety of threats from mostly human-related origins. Our objective was to define specific BCIs for the subspecies that, coupled with additional health, genetic and …

Recent Development Of Unpowered Exoskeletons For Lower Extremity: A Survey, Tao Liu, Bin Zhang, Bin Zhang, Micheal G. Pecht

Faculty Publications

Unpowered exoskeletons (UEs) have attracted extensive research attentions for their portability, handleability and simplicity. However, designing exoskeletons without any active actuators is a great challenge because essential criteria such as performance enhancement, low impedance, and comfort must be met. This paper reviews the UEs researches from three aspects including modeling for understanding gait pattern, mechanical designs, and validation methods, which are main considerations of designing UEs. This review is based on the reported works in the past two decades and underlines some practical opportunities and challenges. Statistical data analysis and critical reviews are stated to understand human gait patterns, designing …

Editorial: Unraveling Mechanisms Underlying Annual Plankton Blooms In The North Atlantic And Their Implications For Biogenic Aerosol Properties And Cloud Formation, Michael Behrenfeld, Sarah D. Brooks, Peter Gaube, Kristina D.A. Mojica

Faculty Publications

No abstract provided.

The Response Of Airborne Mycobiome To Dust Storms In The Eastern Mediterranean, Xuefeng Peng, Daniela Gat, Adina Paytan, Yinon Rudich

Faculty Publications

Airborne microbial communities directly impact the health of humans, animals, plants, and receiving ecosystems. While airborne bacterial and fungal communities have been studied by both cultivation-based methods and metabarcoding surveys targeting specific molecular markers, fewer studies have used shotgun metagenomics to study the airborne mycobiome. We analyzed the diversity and relative abundance of fungi in nine airborne metagenomes collected on clear days (“background”) and during dust storms in the Eastern Mediterranean. The negative correlation between the relative abundance of fungal reads and the concentrations of atmospheric particulate matter having an aerodynamic diameter smaller than 10 μm (PM10) indicate that dust …

Recognition And Screening For Chagas Disease In The Usa, Rachel Marcus, Andres F. Henao-Martinez, Melissa Nolan Ph.D., Mph, Elizabeth Livingston, Stephen A. Klotz, Robert H. Gilman, Monica Miranda-Schaeubinger, Sheba Meymandi

Faculty Publications

Chagas disease (CD), caused by the protozoan Trypanosoma cruzi, is a public health concern, mainly among countries in South and Central America. However, despite the large number of immigrants from endemic countries living in the USA, awareness of CD is poor in the medical community, and therefore it is significantly underdiagnosed. To avoid the catastrophic cardiac complications of CD and to prevent maternal–fetal transmission, widespread educational programs highlighting the need for diagnosis are urgently needed.

The Ghost Of Hosts Past: Impacts Of Host Extinction On Parasite Specificity, Maxwell J. Farrell, Andrew W. Park, Clayton E. Cressler, Tad Dallas, Shan Huang, Nicole Mideo, Ignacio Morales-Castilla, T. Jonathan Davies, Patrick Stephens

Faculty Publications

A growing body of research is focused on the extinction of parasite species in response to host endangerment and declines. Beyond the loss of parasite species richness, host extinction can impact apparent parasite host specificity, as measured by host richness or the phylogenetic distances among hosts. Such impacts on the distribution of parasites across the host phylogeny can have knock-on effects that may reshape the adaptation of both hosts and parasites, ultimately shifting the evolutionary landscape underlying the potential for emergence and the evolution of virulence across hosts. Here, we examine how the reshaping of host phylogenies through extinction may …

The Future Of Zoonotic Risk Prediction, Colin J. Carlson, Maxwell J. Farrell, Zoe Grange, Barbara A. Han, Nardus Mollentze, Alexandra L. Phelan, Angela L. Rasmussen, Gregory F. Albery, Bernard Bett, David M. Brett-Major, Lily E. Cohen, Tad Dallas, Evan A. Eskew, Anna C. Fagre, Kristian M. Forbes, Rory Gibb, Sam Halabi, Charlotte C. Hammer, Rebecca Katz, Jason Kindrachuk, Renata L. Muylaert, Felicia B. Nutter, Joseph Ogola, Kevin J. Olival, Michelle Rourke, Sadie J. Ryan, Noam Ross, Stephanie N. Seifert, Tarja Sironen, Claire J. Standley, Kishana Taylor, Marietjie Venter, Paul W. Webala

Faculty Publications

In the light of the urgency raised by the COVID-19 pandemic, global investment in wildlife virology is likely to increase, and new surveillance programmes will identify hundreds of novel viruses that might someday pose a threat to humans. To support the extensive task of laboratory characterization, scientists may increasingly rely on data-driven rubrics or machine learning models that learn from known zoonoses to identify which animal pathogens could someday pose a threat to global health. We synthesize the findings of an interdisciplinary workshop on zoonotic risk technologies to answer the following questions. What are the prerequisites, in terms of open …

Epidemiology Of Type 2 Diabetes In The Middle East And North Africa: Challenges And Call For Action, Imad El-Kebbi, Nayda Bidikian, Layal Hneiny, Mona Nasrallah

Faculty Publications

Type 2 diabetes continues to be a serious and highly prevalent public health problem worldwide. In 2019, the highest prevalence of diabetes in the world at 12.2%, with its associated morbidity and mortality, was found in the Middle East and North Africa region. In addition to a genetic predisposition in its population, evidence suggests that obesity, physical inactivity, urbanization, and poor nutritional habits have contributed to the high prevalence of diabetes and prediabetes in the region. These risk factors have also led to an earlier onset of type 2 diabetes among children and adolescents, negatively affecting the productive years of …

A Southwestern United States Pilot Investigation Of Triatomine–Mite Prevalence, Kyndall C. Dye-Braumuller, Hanna Waltz, Mary K. Lynn, Stephen A. Klotz, Justin O. Schmidt, Alvaro Romero, Marvin Stanley Rodriguez Aquino, Jose Ricardo Palacios Valladares, Pamela Michelle Cornejo Rivas, Melissa Nolan Ph.D., Mph

Faculty Publications

An estimated 70 million persons in the Western Hemisphere are living at risk for Chagas disease, a parasitic infection transmitted to humans by over 156 different competent triatomine insect vector species. Prior Pan American Health Organization insecticide campaigns throughout Latin America in the 1990s and 2000s demonstrated that domestic insecticide spraying had temporary effects, which resulted in the re-establishment of triatomine species within a few years. Serendipitously, our team found ectoparasitic mites parasitizing triatomines collected from the field in multiple locations in the southwestern United States, where human–triatomine interaction was high but human parasite infection remains low. Upon further investigation …