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Faculty Bibliography 2010s

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2010

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Articles 121 - 148 of 148

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Spitzer Irac Secondary Eclipse Photometry Of The Transiting Extrasolar Planet Hat-P-1b, Kamen Todorov, Drake Deming, Jospeph Harrington, Kevin B. Stevenson, William C. Bowman, Sarah Nymeyer, Jonathan J. Fortney, Gaspar A. Bakos Jan 2010

Spitzer Irac Secondary Eclipse Photometry Of The Transiting Extrasolar Planet Hat-P-1b, Kamen Todorov, Drake Deming, Jospeph Harrington, Kevin B. Stevenson, William C. Bowman, Sarah Nymeyer, Jonathan J. Fortney, Gaspar A. Bakos

Faculty Bibliography 2010s

We report Spitzer/IRAC photometry of the transiting giant exoplanet HAT-P-1b during its secondary eclipse. This planet lies near the postulated boundary between the pM and pL-class of hot Jupiters, and is important as a test of models for temperature inversions in hot Jupiter atmospheres. We derive eclipse depths for HAT-P-1b, in units of the stellar flux, that are: 0.080%+/- 0.008% [3.6 mu m], 0.135%+/- 0.022% [4.5 mu m], 0.203%+/- 0.031% [5.8 mu m], and 0.238%+/- 0.040% [8.0 mu m]. These values are best fit using an atmosphere with a modest temperature inversion, intermediate between the archetype inverted atmosphere (HD 209458b) …


Time-Dependent Density-Matrix Functional Theory For Biexcitonic Phenomena, Volodymyr Turkowski, Carsten A. Ullrich, Talat S. Rahman, Michael N. Leuenberger Jan 2010

Time-Dependent Density-Matrix Functional Theory For Biexcitonic Phenomena, Volodymyr Turkowski, Carsten A. Ullrich, Talat S. Rahman, Michael N. Leuenberger

Faculty Bibliography 2010s

We formulate a time-dependent density-matrix functional theory (TDDMFT) approach for higher-order correlation effects like biexcitons in optical processes in solids based on a reduced two-particle density-matrix formalism within the normal orbital representation. A TDDMFT version of the Schrodinger equation for biexcitons in terms of one- and two-body reduced density matrices is derived, which leads to finite biexcitonic binding energies already with an adiabatic approximation. Biexcitonic binding energies for several bulk semiconductors are calculated using a contact biexciton model.


Decoherence By Electromagnetic Fluctuations In Double-Quantum-Dot Charge Qubits, Diego C. B. Valente, Eduardo R. Mucciolo, F. K. Wilhelm Jan 2010

Decoherence By Electromagnetic Fluctuations In Double-Quantum-Dot Charge Qubits, Diego C. B. Valente, Eduardo R. Mucciolo, F. K. Wilhelm

Faculty Bibliography 2010s

We discuss decoherence due to electromagnetic fluctuations in charge qubits formed by two lateral quantum dots. We use effective circuit model to evaluate correlations of voltage fluctuations in the qubit setup. These correlations allows us to estimate energy (T(1)) and phase (T(2)) relaxation times of the qubit system. Our theoretical estimate of the quality factor due to dephasing by electromagnetic fluctuations yields values much higher than those found in recent experiments, indicating that other sources of decoherence play a dominant role.


Delta-Expansion Method For Nonlinear Stochastic Differential Equations Describing Wave Propagation In A Random Medium, Robert A. Van Gorder Jan 2010

Delta-Expansion Method For Nonlinear Stochastic Differential Equations Describing Wave Propagation In A Random Medium, Robert A. Van Gorder

Faculty Bibliography 2010s

We apply the delta-expansion method to nonlinear stochastic differential equations describing wave propagation in a random medium. In particular, we focus our attention on a model describing a nonlinear wave propagating in a turbulent atmosphere which has random variations in the refractive index (we take these variations to be stochastic). The method allows us to construct much more reasonable perturbation solutions with relatively few terms (compared to standard "small-parameter" perturbation methods) due to more accurate linearization used in constructing the initial approximation. We demonstrate that the method allows one to compute effective wave numbers more precisely than other methods applied …


A New Target For Amyloid Beta Toxicity Validated By Standard And High-Throughput Electrophysiology, Kucku Varghese, Peter Molnar, Mainak Das, Neelima Bhargava, Stephen Lambert, Mark S. Kindy, James J. Hickman Jan 2010

A New Target For Amyloid Beta Toxicity Validated By Standard And High-Throughput Electrophysiology, Kucku Varghese, Peter Molnar, Mainak Das, Neelima Bhargava, Stephen Lambert, Mark S. Kindy, James J. Hickman

Faculty Bibliography 2010s

Background: Soluble oligomers of amyloid beta (A beta) are considered to be one of the major contributing factors to the development of Alzheimer's disease. Most therapeutic development studies have focused on toxicity directly at the synapse. Methodology/Principal Findings: Patch clamp studies detailed here have demonstrated that soluble A beta can also cause functional toxicity, namely it inhibits spontaneous firing of hippocampal neurons without significant cell death at low concentrations. This toxicity will eventually lead to the loss of the synapse as well, but may precede this loss by a considerable amount of time. In a key technological advance we have …


Chloroplast-Derived Enzyme Cocktails Hydrolyse Lignocellulosic Biomass And Release Fermentable Sugars, Dheeraj Verma, Anderson Kanagaraj, Shuangxia Jin, Nameirakpam D. Singh, Pappachan E. Kolattukudy, Henry Daniell Jan 2010

Chloroplast-Derived Enzyme Cocktails Hydrolyse Lignocellulosic Biomass And Release Fermentable Sugars, Dheeraj Verma, Anderson Kanagaraj, Shuangxia Jin, Nameirakpam D. Singh, Pappachan E. Kolattukudy, Henry Daniell

Faculty Bibliography 2010s

It is widely recognized that biofuel production from lignocellulosic materials is limited by inadequate technology to efficiently and economically release fermentable sugars from the complex multi-polymeric raw materials. Therefore, endoglucanases, exoglucanase, pectate lyases, cutinase, swollenin, xylanase, acetyl xylan esterase, beta glucosidase and lipase genes from bacteria or fungi were expressed in Escherichia coli or tobacco chloroplasts. A PCR-based method was used to clone genes without introns from Trichoderma reesei genomic DNA. Homoplasmic transplastomic lines showed normal phenotype and were fertile. Based on observed expression levels, up to 49, 64 and 10, 751 million units of pectate lyases or endoglucanase can …


Oral Delivery Of Bioencapsulated Coagulation Factor Ix Prevents Inhibitor Formation And Fatal Anaphylaxis In Hemophilia B Mice, Dheeraj Verma, Babak Moghimi, Paul A, Loduca, Harminder D. Singh, Brad E. Hoffman, Roland W. Herzog, Henry Daniell Jan 2010

Oral Delivery Of Bioencapsulated Coagulation Factor Ix Prevents Inhibitor Formation And Fatal Anaphylaxis In Hemophilia B Mice, Dheeraj Verma, Babak Moghimi, Paul A, Loduca, Harminder D. Singh, Brad E. Hoffman, Roland W. Herzog, Henry Daniell

Faculty Bibliography 2010s

To address complications of pathogenic antibody or life-threatening anaphylactic reactions in protein replacement therapy for patients with hemophilia or other inherited protein deficiencies, we have developed a prophylactic protocol using a murine hemophilia B model. Oral delivery of coagulation factor IX fused with cholera toxin beta-subunit (with or without a furin cleavage site; CTB-FFIX or CTB-FIX), expressed in chloroplasts (up to 3.8% soluble protein or 0.4 mg/g leaf tissue), bioencapsulated in plant cells, effectively blocked formation of inhibitory antibodies (undetectable or up to 100-fold less than controls). Moreover, this treatment eliminated fatal anaphylactic reactions that occurred after four to six …


Evolving Static Representations For Task Transfer, Phillip Verbancsics, Kenneth O. Stanley Jan 2010

Evolving Static Representations For Task Transfer, Phillip Verbancsics, Kenneth O. Stanley

Faculty Bibliography 2010s

An important goal for machine learning is to transfer knowledge between tasks. For example, learning to play RoboCup Keepaway should contribute to learning the full game of RoboCup soccer. Previous approaches to transfer in Keepaway have focused on transforming the original representation to fit the new task. In contrast, this paper explores the idea that transfer is most effective if the representation is designed to be the same even across different tasks. To demonstrate this point, a bird's eye view (BEV) representation is introduced that can represent different tasks on the same two-dimensional map. For example, both the 3 vs. …


Climatic Variability Leads To Later Seasonal Flowering Of Floridian Plants, Betsy Von Holle, Yun Wei, David Nickerson Jan 2010

Climatic Variability Leads To Later Seasonal Flowering Of Floridian Plants, Betsy Von Holle, Yun Wei, David Nickerson

Faculty Bibliography 2010s

Understanding species responses to global change will help predict shifts in species distributions as well as aid in conservation. Changes in the timing of seasonal activities of organisms over time may be the most responsive and easily observable indicator of environmental changes associated with global climate change. It is unknown how global climate change will affect species distributions and developmental events in subtropical ecosystems or if climate change will differentially favor nonnative species. Contrary to previously observed trends for earlier flowering onset of plant species with increasing spring temperatures from mid and higher latitudes, we document a trend for delayed …


Neural Membrane Signaling Platforms, Ron Wallace Jan 2010

Neural Membrane Signaling Platforms, Ron Wallace

Faculty Bibliography 2010s

Throughout much of the history of biology, the cell membrane was functionally defined as a semi-permeable barrier separating aqueous compartments, and an anchoring site for proteins. Little attention was devoted to its possible regulatory role in intracellular molecular processes and neuron electrical signaling. This article reviews the history of membrane studies and the current state of the art. Emphasis is placed on natural and artificial membrane studies of electric field effects on molecular organization, especially as these may relate to impulse propagation in neurons. Implications of these studies for new designs in artificial intelligence are briefly examined.


Analysis Of Throughput For Multilayer Infrared Meanderline Waveplates, Samuel L. Wadsworth, Glenn D. Boreman Jan 2010

Analysis Of Throughput For Multilayer Infrared Meanderline Waveplates, Samuel L. Wadsworth, Glenn D. Boreman

Faculty Bibliography 2010s

A meanderline wave retarder is a unique type of frequency-selective-surface (FSS) that enables a change in the state of optical polarization. The principles of operation are very similar to a typical crystalline waveplate, such that the artificially structured meanderline array has both 'slow' and 'fast' axes that provide a phase offset between two orthogonal wave components. In this paper, we study the behavior and response of multilayered meanderline quarter-wave retarders designed for operation at 10.6 mu m wavelength (28.28 THz). It will be shown that meanderline quarter-wave plates with more than a single layer exhibit improved transmission throughput at infrared …


Folate Receptor Targeting Silica Nanoparticle Probe For Two-Photon Fluorescence Bioimaging, Xuhua Wang, Sheng Yao, Hyo-Yang Ahn, Yuanwei Zhang, Mykhailo V. Bondar, Joseph A. Torres, Kevin D. Belfield Jan 2010

Folate Receptor Targeting Silica Nanoparticle Probe For Two-Photon Fluorescence Bioimaging, Xuhua Wang, Sheng Yao, Hyo-Yang Ahn, Yuanwei Zhang, Mykhailo V. Bondar, Joseph A. Torres, Kevin D. Belfield

Faculty Bibliography 2010s

Narrow dispersity organically modified silica nanoparticles (SiNPs), diameter similar to 30 nm, entrapping a hydrophobic two-photon absorbing fluorenyl dye, were synthesized by hydrolysis of triethoxyvinylsilane and (3-aminopropyl) triethoxysilane in the nonpolar core of Aerosol-OT micelles. The surface of the SiNPs were functionalized with folic acid, to specifically deliver the probe to folate receptor (FR) over-expressing Hela cells, making these folate two-photon dye-doped SiNPs potential candidates as probes for two-photon fluorescence microscopy (2PFM) bioimaging. In vitro studies using FR over-expressing Hela cells and low FR expressing MG63 cells demonstrated specific cellular uptake of the functionalized nanoparticles. One-photon fluorescence microscopy (1PFM) imaging, …


The Adaptive Function Of Masturbation In A Promiscuous African Ground Squirrel, Jane M. Waterman Jan 2010

The Adaptive Function Of Masturbation In A Promiscuous African Ground Squirrel, Jane M. Waterman

Faculty Bibliography 2010s

Background: Studies of animal mating systems increasingly emphasize female multiple mating and cryptic sexual selection, particularly sperm competition. Males under intense sperm competition may manipulate sperm quantity and quality through masturbation, which could waste sperm and decrease fertility. I examined the factors influencing masturbation by male Cape ground squirrels (Xerus inauris) in light of a number of functional hypotheses. Methodology: Observational data on a marked population of squirrels were collected in east-central Namibia using scan and all-occurrences sampling. Findings: Masturbation was far more frequent on days of female oestrus and mostly occurred after copulation. Masturbation rates were higher in dominant …


Nd:Yag-Co2 Double-Pulse Laser Induced Breakdown Spectroscopy Of Organic Films, Matthew Weidman, Matthieu Baudelet, Santiago Palanco, Michael Sigmann, Paul J. Dagdigian, Martin Richardson Jan 2010

Nd:Yag-Co2 Double-Pulse Laser Induced Breakdown Spectroscopy Of Organic Films, Matthew Weidman, Matthieu Baudelet, Santiago Palanco, Michael Sigmann, Paul J. Dagdigian, Martin Richardson

Faculty Bibliography 2010s

Laser-induced breakdown spectroscopy (LIBS) using double-pulse irradiation with Nd:YAG and CO2 lasers was applied to the analysis of a polystyrene film on a silicon substrate. An enhanced emission signal, compared to single-pulse LIBS using a Nd: YAG laser, was observed from atomic carbon, as well as enhanced molecular emission from C-2 and CN. This double-pulse technique was further applied to 2,4,6-trinitrotoluene residues, and enhanced LIBS signals for both atomic carbon and molecular CN emission were observed; however, no molecular C-2 emission was detected.


Liquid Crystal Parameter Analysis For Tunable Photonic Bandgap Fiber Devices, Johannes Weirich, Jesper Lægsgaard, Lei Wei, Thomas Tanggaard Alkeskjold, Thomas X. Wu, Shin-Tson Wu, Anders Bjarklev Jan 2010

Liquid Crystal Parameter Analysis For Tunable Photonic Bandgap Fiber Devices, Johannes Weirich, Jesper Lægsgaard, Lei Wei, Thomas Tanggaard Alkeskjold, Thomas X. Wu, Shin-Tson Wu, Anders Bjarklev

Faculty Bibliography 2010s

We investigate the tunability of splay-aligned liquid crystals for the use in solid core photonic crystal fibers. Finite element simulations are used to obtain the alignment of the liquid crystals subject to an external electric field. By means of the liquid crystal director field the optical permittivity is calculated and used in finite element mode simulations. The suitability of liquid crystal photonic bandgap fiber devices for filters, wave-plates or sensors is highly dependent on the tunability of the transmission spectrum. In this contribution we investigate how the bandgap tunability is determined by the parameters of the liquid crystals. This enables …


Reflecting On The Design And Implementation Issues Of Virtual Environments, Chadwick A. Wingrave, Joseph J. Laviola Jr. Jan 2010

Reflecting On The Design And Implementation Issues Of Virtual Environments, Chadwick A. Wingrave, Joseph J. Laviola Jr.

Faculty Bibliography 2010s

We present a candid reflection on the issues surrounding virtual environment design and implementation (VEDI) in order to: (1) motivate the topic as a research-worthy undertaking, and (2) attempt a comprehensive listing of impeding VEDI issues so they can be addressed. In order to structure this reflection, an idealized model of VEDI is presented. This model, investigated using mixed methods, resulted in 67 distinct issues along the model's transitions and pathways. These were clustered into 11 themes and used to support five VEDI research challenges.


Measurement Of Contractile Stress Generated By Cultured Rat Muscle On Silicon Cantilevers For Toxin Detection And Muscle Performance Enhancement, Kerry Wilson, Mainak Das, Kathryn J. Wahl, Richard J. Colton, James Hickman Jan 2010

Measurement Of Contractile Stress Generated By Cultured Rat Muscle On Silicon Cantilevers For Toxin Detection And Muscle Performance Enhancement, Kerry Wilson, Mainak Das, Kathryn J. Wahl, Richard J. Colton, James Hickman

Faculty Bibliography 2010s

Background: To date, biological components have been incorporated into MEMS devices to create cell-based sensors and assays, motors and actuators, and pumps. Bio-MEMS technologies present a unique opportunity to study fundamental biological processes at a level unrealized with previous methods. The capability to miniaturize analytical systems enables researchers to perform multiple experiments in parallel and with a high degree of control over experimental variables for high-content screening applications. Methodology/Principal Findings: We have demonstrated a biological microelectromechanical system (BioMEMS) based on silicon cantilevers and an AFM detection system for studying the physiology and kinetics of myotubes derived from embryonic rat skeletal …


Design, Implementation, And Testing Of A Cryogenic Loading Capability On An Engineering Neutron Diffractometer, T. R. Woodruff, V. B. Krishnan, B. Clausen, T. Sisneros, V. Livescu, D. W. Brown, M. A. M. Bourke, R. Vaidyanathan Jan 2010

Design, Implementation, And Testing Of A Cryogenic Loading Capability On An Engineering Neutron Diffractometer, T. R. Woodruff, V. B. Krishnan, B. Clausen, T. Sisneros, V. Livescu, D. W. Brown, M. A. M. Bourke, R. Vaidyanathan

Faculty Bibliography 2010s

A novel capability was designed, implemented, and tested for in situ neutron diffraction measurements during loading at cryogenic temperatures on the spectrometer for materials research at temperature and stress at Los Alamos National Laboratory. This capability allowed for the application of dynamic compressive forces of up to 250 kN on standard samples controlled at temperatures between 300 and 90 K. The approach comprised of cooling thermally isolated compression platens that in turn conductively cooled the sample in an aluminum vacuum chamber which was nominally transparent to the incident and diffracted neutrons. The cooling/heat rate and final temperature were controlled by …


Complete Chloroplast Genome Of Oncidium Gower Ramsey And Evaluation Of Molecular Markers For Identification And Breeding In Oncidiinae, Fu-Hui Wu, Ming-Tsair Chan, De-Chih Liao, Chen-Tran Hsu, Yi-Wei Lee, Henry Daniell, Melvin R. Duvall, Choun-Sea Lin Jan 2010

Complete Chloroplast Genome Of Oncidium Gower Ramsey And Evaluation Of Molecular Markers For Identification And Breeding In Oncidiinae, Fu-Hui Wu, Ming-Tsair Chan, De-Chih Liao, Chen-Tran Hsu, Yi-Wei Lee, Henry Daniell, Melvin R. Duvall, Choun-Sea Lin

Faculty Bibliography 2010s

Background: Oncidium spp. produce commercially important orchid cut flowers. However, they are amenable to intergeneric and inter-specific crossing making phylogenetic identification very difficult. Molecular markers derived from the chloroplast genome can provide useful tools for phylogenetic resolution. Results: The complete chloroplast genome of the economically important Oncidium variety Onc. Gower Ramsey (Accession no. GQ324949) was determined using a polymerase chain reaction (PCR) and Sanger based ABI sequencing. The length of the Oncidium chloroplast genome is 146,484 bp. Genome structure, gene order and orientation are similar to Phalaenopsis, but differ from typical Poaceae, other monocots for which there are several published …


Assessing The Long-Term Urban Heat Island In San Antonio, Texas Based On Moderate Resolution Imaging Spectroradiometer/Aqua Data, Hongjie Xie, Ni-Bin Chang, Ammarin Daranpob, David Prado Jan 2010

Assessing The Long-Term Urban Heat Island In San Antonio, Texas Based On Moderate Resolution Imaging Spectroradiometer/Aqua Data, Hongjie Xie, Ni-Bin Chang, Ammarin Daranpob, David Prado

Faculty Bibliography 2010s

Urban environmental conditions are strongly dependent on the land use and land cover properties. Urban and rural areas normally exhibit obvious difference in land surface temperature (LST). The Moderate Resolution Imaging Spectroradiometer (MODIS) Aqua (PM satellite) MYD11A1 temperature products (daily and 1 km spatial resolution) for the period from June 1 to September 30 between 2002 and 2008 were used to screen the existence of urban heat island (UHI) phenomena for the city of San Antonio, TX. 8-day MYD11A2 temperature products between 2002 and 2008 were also retrieved to map the temperature climatology at the 1:30 a.m. for the region. …


A Novel Adaptive Mechanical-Wetting Lens For Visible And Near Infrared Imaging, Su Xu, Yifan Liu, Hongwen Ren, Shin-Tson Wu Jan 2010

A Novel Adaptive Mechanical-Wetting Lens For Visible And Near Infrared Imaging, Su Xu, Yifan Liu, Hongwen Ren, Shin-Tson Wu

Faculty Bibliography 2010s

We demonstrate an adaptive mechanical-wetting lens with a concentric reservoir to reduce image aberrations and overcome the gravity effect. This lens adopts liquid pressure to change the interface between two immiscible liquids which, in turn, changes the focal length of the resultant liquid lens. Good optical performance, high resolution, and a wide dynamic range of both positive and negative optical power are achieved. Since no PDMS is employed, such lenses can extend their working range to infrared region by choosing proper liquids.


A Shortstraw-Based Algorithm For Corner Finding In Sketch-Based Interfaces, Yiyan Xiong, Joseph J. Laviola Jr. Jan 2010

A Shortstraw-Based Algorithm For Corner Finding In Sketch-Based Interfaces, Yiyan Xiong, Joseph J. Laviola Jr.

Faculty Bibliography 2010s

We present IStraw, a corner finding technique based on the ShortStraw algorithm. This new algorithm addresses deficiencies with ShortStraw while maintaining its simplicity and efficiency. We also develop an extension for ink strokes containing curves and arcs. We compare our algorithm against ShortStraw and two other state of the art corner finding approaches, MergeCF and Sezgin's scale space algorithm. Based on an all-or-nothing accuracy metric, IStraw shows significant improvements over these algorithms for ink strokes with and without curves. (C) 2010 Elsevier Ltd. All rights reserved.


Modeling And Simulation Of The Horizontal Component Of The Geomagnetic Field By Fractional Stochastic Differential Equations In Conjunction With Empirical Mode Decomposition, Zu-Guo Yu, Vo Anh, Yang Wang, Dong Mao, James Wanliss Jan 2010

Modeling And Simulation Of The Horizontal Component Of The Geomagnetic Field By Fractional Stochastic Differential Equations In Conjunction With Empirical Mode Decomposition, Zu-Guo Yu, Vo Anh, Yang Wang, Dong Mao, James Wanliss

Faculty Bibliography 2010s

In this paper, we investigate the characteristics and develop a stochastic model for the horizontal component B-x of the magnetic field at 22 stations of the global near-real-time magnetic observatory network INTERMAGNET. The model is in the form of a fractional stochastic differential equation. A method to estimate the parameters on the basis of observed data and to simulate the data using the model is given. The degree of fractional differentiation and the alpha-stability exponent of the process are employed to cluster the stations. The B-x time series possess pronounced local trends, which must be removed before modeling and simulation …


Determining Time Resolution Of Microchannel Plate Detectors For Electron Time-Of-Flight Spectrometers, Qi Zhang, Kun Zhao, Zenghu Chang Jan 2010

Determining Time Resolution Of Microchannel Plate Detectors For Electron Time-Of-Flight Spectrometers, Qi Zhang, Kun Zhao, Zenghu Chang

Faculty Bibliography 2010s

The temporal resolution of a 40 mm diameter chevron microchannel plate (MCP) detector followed by a constant fraction discriminator and a time-to-digital converter was determined by using the third order harmonic of 25 fs Ti:sapphire laser pulses. The resolution was found to deteriorate from 200 to 300 ps as the total voltage applied on the two MCPs increased from 1600 to 2000 V. This was likely due to a partial saturation of the MCP and/or the constant fraction discriminator working with signals beyond its optimum range of pulse width and shape.


A Cell-Permeable Stat3 Sh2 Domain Mimetic Inhibits Stat3 Activation And Induces Antitumor Cell Effects In Vitro, Wei Zhao, Soumya Jaganathan, James Turkson Jan 2010

A Cell-Permeable Stat3 Sh2 Domain Mimetic Inhibits Stat3 Activation And Induces Antitumor Cell Effects In Vitro, Wei Zhao, Soumya Jaganathan, James Turkson

Faculty Bibliography 2010s

Given the role of constitutively active Signal Transducer and Activator of Transcription (Stat) 3 in human tumors, Stat3 inhibitors would be useful as novel therapeutics and as tools for probing Stat3-mediated tumor processes. We here in report that a 28-mer peptide, SPI, derived from the Stat3 SH2 domain, replicates Stat3 biochemical properties. Studies show SPI and Stat3 (or Stat3 SH2 domain) bind with similar affinities to known Stat3-binding phosphotyrosine (pY) peptide motifs, including those of the epidermal growth factor receptor (EGFR) and the high-affinity, IL-6R/gp130-derived pY-peptide, GpYLPQTV-NH(2). Consequently, SPI functions as a potent and selective inhibitor of Stat3 SH2 domain: …


Birefringent Properties Of Cyclic Block Copolymers And Low-Retardation-Film Development, Weijun Zhou, Charles Diehl, Dan Murray, Kurt A. Koppi, Stephen Hahn, Shin-Tson Wu Jan 2010

Birefringent Properties Of Cyclic Block Copolymers And Low-Retardation-Film Development, Weijun Zhou, Charles Diehl, Dan Murray, Kurt A. Koppi, Stephen Hahn, Shin-Tson Wu

Faculty Bibliography 2010s

Cyclic block copolymers (CBCs) are a new class of optical polymers made by fully hydrogenating block copolymers of styrene and conjugated diene. This class of materials has excellent optical transparency, photostability, and good thermal resistance. By changing the copolymer composition and the resulting block-copolymer morphology, a unique set of birefringence properties can be achieved. The focus of this work was to study various sources of birefringence in block copolymers using a series of model CBC materials. One particularly interesting finding relates to the development of an ultra-low-phase-retardation CBC film. Unlike the conventional approach of using an additive or blend, a …


Pt Optical Lattices And Universality In Beam Dynamics, Mei C. Zheng, Demetrios N. Christodoulides, Ragnar Fleischmann, Tsampikos Kottos Jan 2010

Pt Optical Lattices And Universality In Beam Dynamics, Mei C. Zheng, Demetrios N. Christodoulides, Ragnar Fleischmann, Tsampikos Kottos

Faculty Bibliography 2010s

Beam dynamics in synthetic optical media with PT symmetries imposed by a balanced arrangement of gain or loss is investigated. We find that the beam power evolution is insensitive to microscopic details of the system and that it follows three distinct universal laws which depend only on the magnitude of the gain or loss parameter. Our theoretical calculations are confirmed numerically for the experimentally realizable case of a lattice consisting of coupled PT-symmetric dimers


Rnamotifscan: Automatic Identification Of Rna Structural Motifs Using Secondary Structural Alignment, Cuncong Zhong, Haixu Tang, Shaojie Zhang Jan 2010

Rnamotifscan: Automatic Identification Of Rna Structural Motifs Using Secondary Structural Alignment, Cuncong Zhong, Haixu Tang, Shaojie Zhang

Faculty Bibliography 2010s

Recent studies have shown that RNA structural motifs play essential roles in RNA folding and interaction with other molecules. Computational identification and analysis of RNA structural motifs remains a challenging task. Existing motif identification methods based on 3D structure may not properly compare motifs with high structural variations. Other structural motif identification methods consider only nested canonical base-pairing structures and cannot be used to identify complex RNA structural motifs that often consist of various non-canonical base pairs due to uncommon hydrogen bond interactions. In this article, we present a novel RNA structural alignment method for RNA structural motif identification, RNAMotifScan, …