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Articles 9511 - 9540 of 35659
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Therapeutic Potential Of A Plant-Made Cholera Toxin B Subunit Variant For The Treatment Of Ulcerative Colitis., Joshua Mark Royal
Therapeutic Potential Of A Plant-Made Cholera Toxin B Subunit Variant For The Treatment Of Ulcerative Colitis., Joshua Mark Royal
Electronic Theses and Dissertations
Cholera toxin B subunit (CTB) is a mucosal immunomodulatory protein that induces robust mucosal and systemic antibody responses. This well-known biological activity has been exploited in cholera prevention (as a component of Dukoral® vaccine) and vaccine development for decades. On the other hand, several studies have investigated CTB’s immunotherapeutic potential in the treatment of inflammatory diseases such as Crohn’s disease and asthma. Furthermore, we recently found that a plant-made variant of CTB (CTBp) could induce colon epithelial wound healing in mouse colitis models. In this thesis, it is revealed that the wound healing effects are unique to the plant-made variant, …
Political Activism And Resistance In Irish America : The Clan Na Gael 1912-1916., Sara Bethany Bornemann
Political Activism And Resistance In Irish America : The Clan Na Gael 1912-1916., Sara Bethany Bornemann
Electronic Theses and Dissertations
This thesis is a historical examination of a group of male Irish Americans, the Clan na Gael, that sought Ireland’s independence from Britain during the years 1912-1916. This is a chronological study of the four years leading up to the Irish rebellion known as the Easter Rising, but it is examined from the American side of the Atlantic. The Clan na Gael was not successful politically, but had outsized influence financially on the efforts to gain Ireland’s independence. Analysis of primary source material makes the compelling argument that in focusing on elite political actors, maintaining a vociferous public relations …
Potential For Developing Run-Of-River Systems In Eastern Kentucky : A Gis Approach To Site Suitability., Thomas Jeffords
Potential For Developing Run-Of-River Systems In Eastern Kentucky : A Gis Approach To Site Suitability., Thomas Jeffords
Electronic Theses and Dissertations
Coal has a questionable future with the potential exhaustion of available coal. Alternate sources of energy production should be considered, such as hydropower dams, or the more environmentally friendly, Run of River (RoR) hydropower system. This study seeks to answer the question: What is the potential for RoR hydroelectric systems in Eastern Kentucky counties with significant decreases in coal production and employment? I hypothesize that GIS will identify suitable sites within Pike County for RoR systems. Site suitability for Eastern Kentucky was assessed and determined that Pike County did not have a suitable physical environment for RoR systems. The power …
Segmentation, Tracking, And Kinematics Of Lung Parenchyma And Lung Tumors From 4d Ct With Application To Radiation Treatment Planning., Jungwon Cha
Electronic Theses and Dissertations
This thesis is concerned with development of techniques for efficient computerized analysis of 4-D CT data. The goal is to have a highly automated approach to segmentation of the lung boundary and lung nodules inside the lung. The determination of exact lung tumor location over space and time by image segmentation is an essential step to track thoracic malignancies. Accurate image segmentation helps clinical experts examine the anatomy and structure and determine the disease progress. Since 4-D CT provides structural and anatomical information during tidal breathing, we use the same data to also measure mechanical properties related to deformation of …
A Study Of Gpr3, Gpr6, Of Gpr12 As Novel Molecular Targets For Cannabidiol., Alyssa S. Laun
A Study Of Gpr3, Gpr6, Of Gpr12 As Novel Molecular Targets For Cannabidiol., Alyssa S. Laun
Electronic Theses and Dissertations
The G protein-coupled receptors 3, 6, and 12 (GPR3, GPR6, and GPR12) comprise a family of closely related orphan receptors with no confirmed endogenous ligands. These receptors are constitutively active, capable of signaling through G protein and non-G protein mediated mechanisms. These orphan receptors have previously been reported to play important roles in many normal physiological functions and to be involved in a variety of pathological conditions. Although they are orphans, GPR3, GPR6, and GPR12 are phylogenetically most closely related to the cannabinoid receptors. Using β-arrestin2 recruitment and cAMP accumulation assays, we have recently found that the non-psychoactive phytocannabinoid cannabidiol …
African American Grandmothers As The Black Matriarch : You Don't Live For Yourself., Tanisha Nicole Stanford
African American Grandmothers As The Black Matriarch : You Don't Live For Yourself., Tanisha Nicole Stanford
Electronic Theses and Dissertations
This study examined historical and contemporary roles of African American grandmothers within the familial system, and their socio-psychological experiences. The primary method of data collection was semi-structured, conversational style interviews with an oral history aspect. There were six grandmothers interviewed, two from the midwest region of the United States, and four from the southern region. The findings reveal stories that corroborate with the literature on the role of women in African American families and that of the Black matriarch, considering their strength are not inherent but necessary. They are not born matriarchs or strong black women, they become that person …
End-To-End Learning Framework For Circular Rna Classification From Other Long Non-Coding Rnas Using Multi-Modal Deep Learning., Mohamed Chaabane
End-To-End Learning Framework For Circular Rna Classification From Other Long Non-Coding Rnas Using Multi-Modal Deep Learning., Mohamed Chaabane
Electronic Theses and Dissertations
Over the past two decades, a circular form of RNA (circular RNA) produced from splicing mechanism has become the focus of scientific studies due to its major role as a microRNA (miR) ac tivity modulator and its association with various diseases including cancer. Therefore, the detection of circular RNAs is a vital operation for continued comprehension of their biogenesis and purpose. Prediction of circular RNA can be achieved by first distinguishing non-coding RNAs from protein coding gene transcripts, separating short and long non-coding RNAs (lncRNAs), and finally pre dicting circular RNAs from other lncRNAs. However, available tools to distinguish circular …
The Effects Of Polychlorinated Biphenyls Exposure On Non-Alcoholic Fatty Liver Disease : Role Of Aryl Hydrocarbon Receptor., Hongxue Shi
Electronic Theses and Dissertations
Polychlorinated biphenyls (PCBs) are detectable in serum of 100% of adults in US, and has been associated with fatty liver disease in epidemiological studies. PCBs are classified as either dioxin-like (DL) or non-dioxin-like (NDL) PCB based on their ability to activate the aryl hydrocarbon receptor (AhR). We used exposures that reflect human bioaccumulation patterns, which resembles Aroclor 1260 with a low level of the DL-PCB, PCB 126. Our aim was to determine if this exposure will activate the human and mouse AhR and examine if receptor activation influences these steatotic responses due to PCB exposures. DL-PCBs exposure-induced AhR activation in …
Title., Douglas Miller
Title., Douglas Miller
Electronic Theses and Dissertations
Title is a series of drawings that explores the aspects of failed projects and the complications of representation within literary and visual practices. This series is informed by preliminary drawings, marginalia, and written notations that are inherent in the formulation processes of both visual and literary compositions. Through an investigation of the 19th Century Russian author Nikolai Gogol’s unfinished novel Dead Souls, I situate this series of drawings as a means to conflate literary theories with visual representation. In this way, the Title series presents fragmentary images, texts, and digressive narratives that demonstrate intermediaries between propositional states and reconciled …
Inflammasome Independent Leukotriene-B4 Production Drives Crystalline Silica Induced Sterile Inflammation., Bindu Hegde
Inflammasome Independent Leukotriene-B4 Production Drives Crystalline Silica Induced Sterile Inflammation., Bindu Hegde
Electronic Theses and Dissertations
Silicosis is an irreversible lung inflammatory disease caused by chronic exposure to crystalline silica (CS) and is one of the most prevalent occupational diseases worldwide. Lipid chemoattractant Leukotriene B4 (LTB4) plays an important role in neutrophilic inflammation that drives silicosis and promotes lung cancer. Previous studies in our laboratory have demonstrated that CS-induced neutrophilic inflammation and lung tumor burden in K-rasLA1 mice is abrogated in the LTB4-receptor deficient mice. Another pathway whose importance is well studied in the progression of silicosis is the Nalp3 inflammasome pathway. Studies have shown inflammasome- dependent IL-1b to be …
There Is Water In The World For Us : The Environmental Theories Of Alice Walker., Janae Lewis Hall
There Is Water In The World For Us : The Environmental Theories Of Alice Walker., Janae Lewis Hall
Electronic Theses and Dissertations
The emergence of African-American Environmental thought responds to the ongoing erasure of Black experiences and their perspectives on nature. Mainstream environmentalism maintains a legacy of perceived innocence and incorruptibility towards the land, while Black Environmentalism demonstrates the limitations of that ideology. Limitations include the erasure of history in regards to stealing land from Indigenous people, the brutality of slavery, legalized lynching, forced removal from the land, exploitation in sharecropping, destruction of sacred lands, heavy pollution in urban centers, and harmful environmental policies. For Black and Indigenous peoples, it is impossible to view American soil as innocent. This project surveyed the …
Score Study Procedures And Processes Among Instrumental Music Teachers And Students Of Varying Experience., Jacob Mark Mitchell
Score Study Procedures And Processes Among Instrumental Music Teachers And Students Of Varying Experience., Jacob Mark Mitchell
Electronic Theses and Dissertations
Score study is agreed to be an essential part of musical preparation by professional conductors. However, no single method for score study has been established. This thesis examines the score study habits of undergraduate music majors, graduate students with a minimum of five years of instrumental teaching experience, and highly-qualified instrumental music teachers with a minimum of ten years of experience. Qualitative methods are employed, and interview transcriptions are the primary sources of data. Findings showed that instrumental music teachers and those with instrumental teaching experience base many of their score study decisions on the abilities and needs of students …
The Involvement Of Epithelial Cells In Arenavirus-Induced Pathogenesis., Nikole Leslie Margaret Warner
The Involvement Of Epithelial Cells In Arenavirus-Induced Pathogenesis., Nikole Leslie Margaret Warner
Electronic Theses and Dissertations
Mammalian Arenaviruses are a geographically and genetically diverse family of viruses, which is separated into two sub-groups; the Old World (OW) and New World (NW) groups. Of the OW viruses, Lassa virus (LASV), found endemically in Western Africa, is an important human pathogen, causing hundreds of thousands of infections, and several thousand deaths annually. Interestingly, some villages in endemic regions, up to 45% of the population show seropositivity for the virus. It is hypothesized that seropositivity is a result of natural infection through inhalation or ingestion of infectious particles. However, the exact mechanism is still unknown. LASV’s natural reservoir is …
State-Reinforced Self-Governance Of Community-Managed Open Spaces In Chicago, Il And Louisville, Ky., Willow Sequoia Dietsch
State-Reinforced Self-Governance Of Community-Managed Open Spaces In Chicago, Il And Louisville, Ky., Willow Sequoia Dietsch
Electronic Theses and Dissertations
As urban populations rise, small greenspaces, like gardens, are increasingly important to well-being of communities, and urban sustainability as a whole. However, past development, and current political and economic challenges encumber many cities in providing adequate greenspace. Cities like Chicago, IL and Louisville, KY have turned to the communities to manage greenspaces with help from partner organizations. This thesis examines these arrangements, and compares them in terms of several potential factors, (i.e. legal authority, responsibility, and support). Semi-structured interviews of important community greenspace stakeholders, and archival sources including original documents, news articles, and government reports, were used to understand the …
Vinyl Chloride Enhances Diet-Induced Liver Injury Via Metabolic Dyshomeostasis : Critical Role Of Mitochondria., Anna L. Lang
Vinyl Chloride Enhances Diet-Induced Liver Injury Via Metabolic Dyshomeostasis : Critical Role Of Mitochondria., Anna L. Lang
Electronic Theses and Dissertations
Background. Vinyl chloride (VC) is an environmental toxicant and has been shown to be directly hepatotoxic at high exposures. However, recent studies suggest low-level toxicant exposure can cause subtle changes to the liver. Given the high prevalence of non-alcoholic fatty liver disease (NAFLD) in the United States, it is important to determine the impact of low-level toxicant exposure on the progression of underlying liver injury when combined with other factors. Therefore, the overarching goal of this dissertation was to develop a model of VC co-exposure with high-fat diet (HFD) and to determine the mechanisms by which VC contributes to the …
Understanding The Role Of Social Capital On Performance In Family Firms., Mahshid Jessri
Understanding The Role Of Social Capital On Performance In Family Firms., Mahshid Jessri
Electronic Theses and Dissertations
One important form of social capital is family social capital, which is mainly the relationship among family members in family business. In this dissertation, we utilize two perspectives of innovativeness and network mobilization to study the relationship between family social capital and firm performance. In the first study, we examine family social capital as a multidimensional construct, and study the relationship between the three aspects of structural, cognitive, and relational family social capital. The relationship between relational social capital and performance is studied through the lens of network mobilization, and the model investigates how family firm identity alters this relationship, …
Nutritional Virulence Of Legionella Pneumophila., Ashley M. Best
Nutritional Virulence Of Legionella Pneumophila., Ashley M. Best
Electronic Theses and Dissertations
Legionella pneumophila is an environment organism that parasitizes a wide range of protozoa. Growth within the environmental host primes L. pneumophila for infection of human alveolar macrophages when contaminated aerosols are inhaled. Intracellular replication within either host requires the establishment a replicative niche, known as the Legionella-containing vacuole (LCV). Biogenesis of the LCV depends on the type IVb translocation system, the Dot/Icm, to translocation >320 effectors into the host cytosol. Effectors are responsible for preventing lysosome fusion to the LCV, recruitment of ER-derived vesicles to the LCV, and modulation of a plethora of host processes to promote the intracellular …
Gender Boundary Negotiation Within The U.S. Immigrant/Refugee Resettlement : How Transnational Bridge-Building Matters., Telesphore Kagaba
Gender Boundary Negotiation Within The U.S. Immigrant/Refugee Resettlement : How Transnational Bridge-Building Matters., Telesphore Kagaba
Electronic Theses and Dissertations
For the past several decades, social research about U.S. immigrant and refugee resettlement has focused on some of the ways federal and non-governmental organizations help immigrants and refugees integrate into mainstream society. Little research, if any, has explored how giving voice to immigrants and refugees is done in bridging transnational gaps and strengths in the process of their adjustment to the host country. This dissertation is grounded within transnational theory (Avenarius 2012, Levitt 2011, Peteet 1997) that argues that immigrants and refugees bring their experiences and cultures from their home countries, time in refugee camps, and other often traumatic experiences …
Breathing Instruction Of Successful High School Marching Band Directors., Michael A. Alsop
Breathing Instruction Of Successful High School Marching Band Directors., Michael A. Alsop
Electronic Theses and Dissertations
The breath is considered one of the most important factors of playing a wind instrument because it affects nearly every aspect of playing. The purpose of this study was to examine the breathing instruction of successful high school marching band directors. The researcher sought to learn about how often proper breathing is taught, what methods are most commonly used, perceived benefits for the marching members, and potential negative aspects or consequences of breathing instruction. Two-hundred-and-thirteen successful marching band directors were invited to complete a survey consisting of multiple choice, Likert scale, and open-ended questions. Seventy-six directors completed the survey. It …
Functional And Structural Impact Of The Loss Of The Leucine-Rich Repeat Protein Lrit1 In The Mouse Retina., Catherine Ann Cobb
Functional And Structural Impact Of The Loss Of The Leucine-Rich Repeat Protein Lrit1 In The Mouse Retina., Catherine Ann Cobb
Electronic Theses and Dissertations
Mutations in genes encoding the leucine-rich repeat (LRR) proteins nyctalopin and LRIT3 lead to complete congenital stationary night blindness because they are critical to depolarizing bipolar cell function in the retina. LRIT3 has two closely related family members, LRIT1 and LRIT2. In silico analyses of publicly available RNA-Seq data showed that Lrit1 was highly expressed in the retina. Here I describe the expression pattern and impact of loss of LRIT1 on retinal function. To enable these studies, we used CRISPR/Cas9 technology to create an Lrit1-/- mouse line. Retinal morphology and morphometry analyses showed no gross changes in retinal structure …
The Styles Of Criminology : Writing Among The Stars., Ethan Maxwell Higgins
The Styles Of Criminology : Writing Among The Stars., Ethan Maxwell Higgins
Electronic Theses and Dissertations
This study investigates how criminological writing style is "a [more] complicated terrain" than we realize in criminology (Butler, 1990, p. xix). Data is drawn from interviews with forty of the one hundred most influential criminological writers (Walters, 2015) to explore perceptions of good writing in the field, namely in describing writing practices, norms and values. Thus, the findings of this study come in three chapters. The first two result chapters explore the terrain of writing in criminology by presenting perceptions of best practices and values of good writing. The third results chapter then examines these perceptions within a lens of …
Gender And Leadership In Animal Sheltering Organizations., Jennifer Blevins Sinski
Gender And Leadership In Animal Sheltering Organizations., Jennifer Blevins Sinski
Electronic Theses and Dissertations
This study explores the connection between gender, leadership and implementation of best practice strategies to reduce or eliminate euthanasia of healthy, adoptable companion animals in animal sheltering organizations. The purpose of this mixed methods study utilizing an online survey and in-depth interviews is to explore the impact of gender and animal sheltering leadership on organizational policies, as well as workers’, and volunteers’ attitudes toward reducing euthanasia in sheltering organizations. It is anticipated that the knowledge generated from this research will provide new insights into animal sheltering policies and procedures and inform sheltering organizations about the connection between gendered leadership in …
Assessment And Optimization Of Environmental Systems Using Data Analysis And Simulation., Milad Ebrahimi
Assessment And Optimization Of Environmental Systems Using Data Analysis And Simulation., Milad Ebrahimi
Electronic Theses and Dissertations
For most environmental systems, specifically wastewater treatment plants and aquifers, a significant number of performance data variables are attained on a time series basis. Due to the interconnectedness of the variables, it is often difficult to assess over-arching trends and quantify temporal operational performance. The objective of this research study was to provide an effective means for comprehensive temporal evaluation of environmental systems. The proposed methodology used several multivariate data analyses and statistical techniques to present an assessment framework for the water quality monitoring programs as well as optimization of treatment plants and aquifer systems. The developed procedure considered the …
Breaking With Tradition(?) : Female Representations Of Heroism In Old English Poetry., Kathryn A. Green
Breaking With Tradition(?) : Female Representations Of Heroism In Old English Poetry., Kathryn A. Green
Electronic Theses and Dissertations
For the Anglo-Saxons, strength, bravery, and the willingness to put oneself in harm’s way for king and kingdom were not only part of contemporary society but recurring themes in Old English literature. Poems like Beowulf and The Battle of Maldon reinforce the important bond between lord and retainer and the heroic ethos key to that relationship. Women were not historically part of this relationship and, therefore, not subject to the heroic code in the same way; consequently, they are rarely seen as anything more than conventional mothers, queens, wives, sisters, daughters, and virgins, all identified by their relationships to men, …
Robust Fuzzy Clustering For Multiple Instance Regression., Mohamed Trabelsi
Robust Fuzzy Clustering For Multiple Instance Regression., Mohamed Trabelsi
Electronic Theses and Dissertations
Multiple instance regression (MIR) operates on a collection of bags, where each bag contains multiple instances sharing an identical real-valued label. Only few instances, called primary instances, contribute to the bag labels. The remaining instances are noise and outliers observations. The goal in MIR is to identify the primary instances within each bag and learn a regression model that can predict the label of a previously unseen bag. In this thesis, we introduce an algorithm that uses robust fuzzy clustering with an appropriate distance to learn multiple linear models from a noisy feature space simultaneously. We show that fuzzy memberships …
A Qualitative Case Study Examination Of Athlete Ally Using Social Movement Theory., Samuel H. Schmidt
A Qualitative Case Study Examination Of Athlete Ally Using Social Movement Theory., Samuel H. Schmidt
Electronic Theses and Dissertations
The following study answered the call for more social movement related studies in sport (Davis-Delano & Crosset, 2008) and lessened the paucity of literature on athlete activism. The purpose of this study was to examine a sport specific social movement organization, Athlete Ally, using Social Movement Theory. Social Movement Theory is guided by three tenets: Resource Mobilization Theory (Edwards & McCarthy, 2004), Political Process Theory (Kriesi, 2004), and Cultural Theory/Frame Analysis (Williams, 2004). Each of these tenets was used to examine the resources exchanged between Athlete Ally and their athlete constituents, determine the strategies for engaging with various sport (i.e. …
The Effects Of Habitat And Connectivity On Tropical Ant Ecology And Behavior., Benjamin Jacob Adams
The Effects Of Habitat And Connectivity On Tropical Ant Ecology And Behavior., Benjamin Jacob Adams
Electronic Theses and Dissertations
This dissertation explores the role that physical connections among and within habitats play in determining the local diversity and behaviors of cursorial organisms. Understanding the processes that regulate local community assembly and that contribute to the maintenance of species diversity is a cornerstone of community ecology. Ants are a useful model for studies of local communities because they are abundant and fulfill a variety of ecological roles. Chapter one of the dissertation examines the how lianas (woody vines) function as connective structures among tree crowns and how these connections affect arboreal ant community structure within a tropical forest canopy. Trees …
Longitudinal Tracking Of Physiological State With Electromyographic Signals., Robert Warren Stallard
Longitudinal Tracking Of Physiological State With Electromyographic Signals., Robert Warren Stallard
Electronic Theses and Dissertations
Electrophysiological measurements have been used in recent history to classify instantaneous physiological configurations, e.g., hand gestures. This work investigates the feasibility of working with changes in physiological configurations over time (i.e., longitudinally) using a variety of algorithms from the machine learning domain. We demonstrate a high degree of classification accuracy for a binary classification problem derived from electromyography measurements before and after a 35-day bedrest. The problem difficulty is increased with a more dynamic experiment testing for changes in astronaut sensorimotor performance by taking electromyography and force plate measurements before, during, and after a jump from a small platform. A …
A Framework For Cardio-Pulmonary Resuscitation (Cpr) Scene Retrieval From Medical Simulation Videos Based On Object And Activity Detection., Anju Panicker Madhusoodhanan Sathik
A Framework For Cardio-Pulmonary Resuscitation (Cpr) Scene Retrieval From Medical Simulation Videos Based On Object And Activity Detection., Anju Panicker Madhusoodhanan Sathik
Electronic Theses and Dissertations
In this thesis, we propose a framework to detect and retrieve CPR activity scenes from medical simulation videos. Medical simulation is a modern training method for medical students, where an emergency patient condition is simulated on human-like mannequins and the students act upon. These simulation sessions are recorded by the physician, for later debriefing. With the increasing number of simulation videos, automatic detection and retrieval of specific scenes became necessary. The proposed framework for CPR scene retrieval, would eliminate the conventional approach of using shot detection and frame segmentation techniques. Firstly, our work explores the application of Histogram of Oriented …
Divergent Evolution Of Di-Lysine Er Retention Vs. Farnesylation Motif-Mediated Anchoring Of The Ankb Virulence Effector., John David Perpich
Divergent Evolution Of Di-Lysine Er Retention Vs. Farnesylation Motif-Mediated Anchoring Of The Ankb Virulence Effector., John David Perpich
Electronic Theses and Dissertations
Legionella pneumophila is an aquatic organism capable of intracellular replication within a wide range of protozoan hosts and within human macrophages where it causes Legionnaires’ Disease. L. pneumophila manipulates a variety of host cell processes by translocating, into the host cell cytosol, more than 300 effector proteins via the type IVB secretion system (T4SS). The AnkB effector from the AA100/130b strain (AnkB-AA100) contains a C-terminal CaaX motif that rapidly becomes farnesylated upon translocation into the host cell and anchored to the cytosolic face of the Legionella-containing vacuole (LCV) membrane, which is essential for intracellular replication. We show that a …