Digital Commons Network^™

Using An Ethics Of Care To Re-Interpret Consent In The Management Of Care For Addiction Disorders, Diann Ecret

Electronic Theses and Dissertations

Patients who suffer from the biological, genetic, epigenetic neurocognitive dysfunction and social sequela of substance use disorders and addiction require the empowering support from healthcare professionals; necessitating the need to utilize an ethics of care to re-interpret consent for the management of care for those who suffer from substance use disorders and addiction. The care of the ‘other’ should embrace a care paradigm that is relational and collaborative in order to eliminate constructs of stigma, moral weakness and individual blame, which isolates those who manifest the trajectory of harms associated with addiction pathology. Relational consent and an ethics of care …

Enhancing Quality Ethics Consultations In Pediatric Medicine, Ariel Clatty

Electronic Theses and Dissertations

Medical ethics consultations occur predominantly in the adult realm of medicine, alternatively in Pediatric Medicine there is a widespread lack of training and skilled professionals to service these requests. Most of the literature in pediatric ethics consultations revolves around mirroring adult ethics consultations. This dissertation seeks to identify and address the issues related to quality of ethics consultations in a clinical setting regarding the organizational and research settings for Pediatric Medicine, and how adopting and applying the guiding standards for ethics consultation using the Core Competencies of the American Society of Bioethics and Humanities will better assist all parties to …

An Ethics Of Care Approach To Managing The Burden Of Alzheimer's Disease, Carrie L. Stott

Electronic Theses and Dissertations

Alzheimer’s disease is a progressive, neurodegenerative disease for which there is currently no cure or effective treatments. The disease has devastating effects on the individuals whom it strikes and because its prevalence continues to rise, it significantly threatens the public good. Throughout its lengthy duration from diagnosis to death there are numerous ethical issues concerning patients individually as well as society generally. The management of the burdens of Alzheimer’s disease presents a formidable ethical challenge from the perspective of patients and society. The ethics of care is adopted to address this problem because of its flexibility to integrate personal care …

The Logic Of Sexuation In Deleuze And Lacan, Matthew Lovett

Electronic Theses and Dissertations

In The Logic of Sexuation in Deleuze and Lacan, I argue for an account of sexual difference that responds to a tension in feminist philosophy, namely, the problem of the ontological status of the sexed body. In so doing, I turn to the work of Gilles Deleuze and Jacques Lacan. I argue that, rather than being antithetical, the two can be productively read together, in particular with regard to this very question. Ultimately basing my reading in the Deleuzian passive syntheses and dynamic geneses of Difference and Repetition and The Logic of Sense as well as in Lacan’s twentieth …

Synthesis Of Novel 5-Substituted Pyrrolo[2,3-D]Pyrimidine Antifolates As Selective And Potent Anti-Tumor Agents, Mohammad Karim

Electronic Theses and Dissertations

In last few decades many folate analogs have been discovered and several compounds are successfully being used as anticancer agents. Methotrexate (MTX), pemetrexed (PMX), raltitrexed (RTX): are a few examples of classical antifolates that are currently in clinical use. Although these compounds are widely used, all of them show dose limiting toxicity due to their non-specific transport into normal cells as well as malignant cells. Currently, clinically used classical antifolates suffer from this disadvantage because there is no way to selectively transport them into malignant cells. Currently available antifolates are transported via reduced folate career (RFC) as well as Folate …

Illuminating The Eighteenth-Century British Stage: Perfecting Performance Through Education, Bethany Csomay

Electronic Theses and Dissertations

Actress studies has become “a truly interdisciplinary field” that “intersect[s] with art, music, literature, history, economics, psychology, anthropology, sociology, and fashion” (Engel 752). While much scholarship has been conducted on the actress’ life, interaction with material culture, public spectacle, authority, femininity, and writings, the role of an actress’ education in her success has yet to be explored adequately or examined beyond biography. My project seeks to examine the educational beginnings of actresses and I assert there are three modes that eighteenth-century actresses often undertook to cultivate their celebrity and success: inheritance, discovery, and trial and error. This project examines the …

The Core Relation Between Hospitality (Philoxenia), Dignity And Vulnerability In Orthodox Christian Bioethics: A Contribution To Global Bioethics, Rabee Toumi

Electronic Theses and Dissertations

In a pluralistic world, reaching consensus in matters of bioethics has proved to be difficult, especially with the political polarization that nurtures inimical differences. This dissertation argues that a middle ground can be identified between the plurality of value systems in contemporary bioethics based on an anthropological approach. This middle ground that reflects commonalities of the human condition can be explored in relation to the foundational principles of Orthodox Christian anthropology. To identify this middle ground the analysis discusses the core relation between hospitality, dignity, and vulnerability as a contribution to global bioethics.

In general, based on Orthodox Christian theology …

Who Says You Can't Go Home?, Holly Dameron

Electronic Theses and Dissertations

Sebastian Barry is most notable for using his ancestors as the main characters in his novel. He takes small wisps of their life and tells a hauntingly, beautiful story. In The Whereabouts of Eneas McNulty, On Canaan’s Side, and The Secret Scripture, he explores the themes of exile and the importance and difficulty of home. The problem with home for all of these characters is the fact that none of them can fully return. In the first chapter, I focus on Eneas’ thought of home, which is the physical land of Ireland. The next chapter is Lilly whose home is …

The Effects Of Aggression On College Adjustment When Accounting For Impulsivity, Christian Wright

Electronic Theses and Dissertations

Aggression and college adjustment has been examined in previous literature many times. Aggression and impulsivity have also been examined in literature numerous times due to being interrelated constructs. However, most research has not examined impulsivity on college adjustment, and no research has looked at aggression on college adjustment accounting for impulsivity. The aim of this study was to further develop the understanding of the relationship between aggression and impulsivity, as well as examine how these two constructs affect social, emotional, and academic adjustment to college. Specifically, this study sought to examine the relationship between aggression and college adjustment accounting for …

The Relationship Between Loneliness, Stress, And Alcohol Consumption Among College Students, I'Esha Baber

Electronic Theses and Dissertations

As the misuse of alcohol among college students remains a public health concern in the United States, students are participating in problematic drinking for various reasons. Loneliness and stress have both been associated with the reasoning behind why some college students participate in heavy drinking. Studies show that students who perceive themselves as under a lot of stress tend to drink more and that students who feel they need to overcome structural and emotional barriers such as loneliness and shyness, use alcohol as a resource. This paper examines the relationship between alcohol consumption, loneliness, and stress. Sixteen students, who attended …

Postwar Churches Of Christ Mission Work: The Philippines As A Case Study, Brady Kal Cox

Electronic Theses and Dissertations

There was a large increase in the number of Churches of Christ missionaries and missionary efforts following World War II (WWII). There were also significant changes and developments in American religious culture following WWII—Churches of Christ were not exempt from these changes. This study examines the question of how postwar developments in American religion influenced missionary efforts of American Churches of Christ by looking at examples of American missionaries in the Philippines.

The study relies heavily on primary sources, including letters and news reports from archival collections, Churches of Christ periodicals, and email correspondence with people familiar with the main …

Differences In Perceived Stress, Locus Of Control, And Coping Styles Used By Male And Female Stem And Human Service Majors, Dawn M. Lowe

Electronic Theses and Dissertations

The current study sought to determine if program type along with gender could predict the type of coping styles students are more likely to use. Secondly, it endeavored to uncover whether a college student’s gender and program type might affect their locus of control and the amount of perceived stress reported. It was hypothesized that female students in Human Service programs would exhibit the most adaptive coping styles, while males in Science, Technology, Engineering, and Mathematics (STEM) programs utilize the most maladaptive coping styles. Moreover, it was postulated that females in Human Service programs would report a more internalized locus …

Petrographic And Stratigraphic Analysis Along The Lower Cretaceous Strata, In Kimble County Texas, Austin C. Wilkerson

Electronic Theses and Dissertations

The upper Trinity Group is predominantly a carbonate system with minor clastic couplets that were deposited during the Middle Cretaceous in the south Llano Uplift region. The upper Trinity Group was deposited on a southward dipping platform in the Kimble County area. Stratigraphic units of the upper Trinity Group are the Hensel Formation, determined to be supratidal claystones, the Glen Rose Formation, which are mudstones that were deposited in a carbonate lagoon, and the Walnut and Fort Terrett formations, which are wackestones to packstones interpreted to have been deposited on a shallow carbonate shelf.

Nine stratigraphic sections were measured along …

Access To Culturally Responsive Teaching For English Language Learners : Mainstream Teacher Perceptions And Practice On Inclusion., Tamela N. Compton

Electronic Theses and Dissertations

This dissertation was designed to inform educators, practitioners, and policy makers on equity-based instruction for ELLs by examining secondary teachers’ perceptions and practice on inclusion. A dominant qualitative research design was used for this study. A survey adapted from Reeves (2002) research on secondary teacher’s attitudes and perceptions on the inclusion of English as a Second Language (ESL) student in mainstream classrooms was administered to 212 secondary teachers in three high schools who have shown significant growth in their ESL student enrollment. The study then interviewed six teachers who participated in the survey on their personal experiences with instructing ELLs …

An Exploration Of Barriers To Health Care Access Among Uninsured Patients: Using The Moderating Effect Of Patients’ Enablement, Enedelia L. Jessup

Electronic Theses and Dissertations

ABSTRACT On March 23, 2010, Congress passed the Patient Protection and Affordable Care Act (ACA) to increase value of care, improve clinical outcomes, decrease health care costs, and increase affordability in health care access. The purpose of the study attempts to examine the moderating effects of patient enablement impacting barriers, low socio economic status, and unmet basic needs, toward health care access in uninsured populations post ACA. Only certain aspects of patient enablement in self-management of an individual’s health care goals have been conducted with uninsured populations with barriers toward health care access. The research design was a quantitative, exploratory, …

Self-Organized Structures: Modeling Polistes Dominula Nest Construction With Simple Rules, Matthew Harrison

Electronic Theses and Dissertations

The self-organized nest construction behaviors of European paper wasps (Polistes dominula) show potential for adoption in artificial intelligence and robotic systems where centralized control proves challenging. However, P. dominula nest construction mechanisms are not fully understood. This research investigated how nest structures stimulate P. dominula worker action at different stages of nest construction. A novel stochastic site selection model, weighted by simple rules for cell age, height, and wall count, was implemented in a three-dimensional, step-by-step nest construction simulation. The simulation was built on top of a hexagonal coordinate system to improve precision and performance. Real and idealized …

Universal Truths, Verisimilitude, And Hyperreality: Baudrillard’S Simulacra And Simulation In Pride And Prejudice And The Lizzie Bennet Diaries., Kathryn M. Kohls

Electronic Theses and Dissertations

This project applies Jean Baudrillard’s Simulacra and Simulation (1981) to Jane Austen’s Pride and Prejudice (1813) and Hank Green and Bernie Su’s The Lizzie Bennet Diaries (2012). By applying Baudrillard’s theory, one can see that Austen’s marriage plot is a shrewd critique of how social simulacra, simulations of reality, dictate how society is structured and interacts. These manipulative simulations are able to be transgressed by the novel’s protagonists, Elizabeth Bennet and Fitzwilliam Darcy. Their ability to find an unsimulated real is appealing to contemporary audiences caught in the hyperreality of the internet age. This leads to a panicked production to …

Confidence In The Police Among Caribbean Countries., Hyunin Baek

Electronic Theses and Dissertations

This dissertation identifies public confidence in the police in contemporary policing, in particular among Caribbean countries. Law enforcement agencies in Caribbean countries have failed to earn confidence from the public. Citizens with a lower level of confidence in the police are unwilling to cooperate and support policing activities, making initiatives of law enforcement agencies difficult to achieve. In order to improve the public-police relationship in Caribbean countries, examinations of public confidence in the police are required. Researchers have developed two theoretical frameworks, the instrumental and expressive models, to explain key factors associated with public confidence in the police. In order …

Loss Of The Na+/H+ Exchange Regulatory Factor 1 Results In Increased Susceptibility To Cisplatin-Induced Acute Kidney Injury., Adrienne M. Bushau-Sprinkle

Electronic Theses and Dissertations

Background. Acute kidney injury (AKI), an abrupt loss of kidney function which carries a high mortality and confers an increased risk of chronic kidney disease, develops in 30% of patients who receive cisplatin, a widely used chemotherapeutic agent [1], [2], [3]. The sodium hydrogen exchange regulatory factor isoform 1 (NHERF1) is a scaffolding protein that anchors multiple membrane proteins, in renal proximal tubules [4]. NHERF-1 deficient mice have aberrant localization of BBM proteins in intracellular compartments [5]. The investigators have recently demonstrated NHERF1 deficient proximal tubule cells have an underlying …

Cognitive Performance Application., Shade El-Hadik

Electronic Theses and Dissertations

This work shows that combining the techniques of neural networking and predictive analytics with the fundamental concepts of computing performance optimization is genuine in many ways. It has the potentials to: (1) reduce infrastructure upgrade costs (2) reduce human interactions, by enabling the system to learn, analyze, and make decisions on its own, and (3) generalize the solutions to other performance problems. This paper attempts to tackle a JVM performance optimization from a different dimension and in a way that can be scaled to other common utilized resources, such as file systems, static contents, search engines, web services...etc. It shows …

Computational Modeling Of Electronically Excited States In Cobalamin-Dependent Reactions., Brady D. Garabato

Electronic Theses and Dissertations

The current understanding of the photolytic properties of Vitamin B12 derivatives or cobalamins are summarized from a computational point of view. The focus is on two non-alkylcobalamins, cyanocobalamin (CNCbl) and hydroxocobalamin (HOCbl), two alkylcobalamins, methylcobalamin (MeCbl) and adenosylcobalamin (AdoCbl), as well as the stable cob(II)alamin radical. Photolysis of alkylcobalamins involves low-lying singlet excited states where photo-dissociation of the Co-C bond forms singlet-born alkyl/cob(II)alamin radical pairs (RPs). Potential energy surfaces (PESs) of low-lying excited states as functions of both axial bonds provide the most reliable tool for analysis of photochemical and photophysical properties. Due to the size limitations associated with the …

Long-Range Electrostatic Interactions In Gold Catalysis And Fluorinating Reagent Development., Zhichao Lu

Electronic Theses and Dissertations

Our research focus is on applying two long range electrostatic interactions--coulombic interaction between ion pairs and hydrogen bonding—to two tasks: exploring counterion effects in gold catalysis and utilizing hydrogen bonding for fluorinating reagent development. Cationic gold catalysis is considered one of the most important breakthroughs in organic synthesis over the past two decades. A wealth of empirical information on counterion effects is now available regarding homogeneous gold catalysis. However, the rational understanding of the counterion effect on reactivity is still elusive. We proposed a widely applicable model to rationalize the kinetic effect in gold catalyzed reaction. We first solved the …

'Where History Meets The Future' : A Historiographic Exploration Of Mississippi : The View From Tougaloo., Khirsten L. Echols

Electronic Theses and Dissertations

“Where History Meets the Future”: A Historiographic Exploration of Mississippi: The View from Tougaloo explores the historical narratives of Historically Black Colleges and Universities, with a special emphasis on Tougaloo College in Tougaloo, Mississippi. In particular, this dissertation examines the ways in which Tougaloo’s official history omits the voices of its student populations. It offers, then, a revisionist reading of the school’s history, constructing a narrative from the perspective of students. Based on hours of archival research and examination of the school’s student newspaper, this dissertation constructs a method that incorporates student voices into the historical narrative. The collection of …

Vertical Gallium Nitride Schottky Diodes For Power Switching Applications., Sowmya Kolli

Electronic Theses and Dissertations

Gallium nitride (GaN) has enormous potential for use in devices operating at high power, frequency and temperature. Its wide band gap, high critical electric field and favourable carrier properties lead to lower switching losses and conduction losses in power electronic devices. However, most GaN rectifiers reported to date exhibit an ON-resistance (Ron) versus breakdown voltage much below theoretical predictions. Heteroepitaxial growth of GaN on substrates such as SiC, Si, and sapphire suffer from a high density of threading dislocations defects due to the mismatch in lattice constants and thermal expansion coefficients. Vertical devices, in which a bulk GaN substrate is …

Characterization Of Type Ii Toxin Anti-Toxin Systems In Aggregatibacter Actinomycetemcomitans., Blair W. Schneider

Electronic Theses and Dissertations

Microbes express many protective mechanisms in response to environmental stress. Toxin/anti-toxin systems encode a biologically active toxin and a labile anti-toxin that inhibits the toxin’s activity. These systems are known to contribute to persister cell and biofilm formation. A. actinomycetemcomitans thrives in the complex oral microbial community and is subjected to continual environmental flux. Little is known regarding the presence and function of TA systems in this organism or their contribution survival in the oral environment. Using BLAST searches and other informatics tools, we identified 11 intact TA systems that are conserved across all seven serotypes of A. actinomycetemcomitans and …

A Qualitative Approach To Examining The Rules Of A Community College And Industry Partnership., Cara Dimattina-Ryan

Electronic Theses and Dissertations

The purpose of this study was to qualitatively examine the governance structure of a successful community college and industry advisory board that collaborate to improve regional workforce development initiatives. The institutional analysis and development (IAD) framework was used as a lens to describe the partnership. The results determined that there were many informal rules that governed the relationship between the community college and industry partners, which led to successful implementation of decisions. The community college leaders created the informal rules with the purpose of encouraging involvement among industry stakeholders, sharing power among all the participants, and facilitating communication. The findings …

"Triggers": Systematic And Social Cues For Black College Student Racial Self-Consciousness And Rejection Sensitivity, Race-Based., Leanna T. Luney

Electronic Theses and Dissertations

Scholars have examined black student well-being in varying ways including through the framing of race-based rejection sensitivity (Downey & Feldman, 1996; Mendoza-Denton, Downey, Purdie, Davis, & Pietrzak, 2002) and racial self-consciousness (Clark & Clark, 1939). Research shows that black students perform worse academically when they display high levels of race-based rejection sensitivity and racial self-conscious levels (Brannon & Taylor, 2015; Clark & Clark, 1939; Koehler & Skvoretz, 2010), and feelings of racial self-consciousness or rejection sensitivity stem from discriminatory and prejudicial experiences. However, research has not fully connected the broader context surrounding black students in college to their high levels …

Machine Learning For Omics Data Analysis., Ameni Trabelsi

Electronic Theses and Dissertations

In proteomics and metabolomics, to quantify the changes of abundance levels of biomolecules in a biological system, multiple sample analysis steps are involved. The steps include mass spectrum deconvolution and peak list alignment. Each analysis step introduces a certain degree of technical variation in the abundance levels (i.e. peak areas) of those molecules. Some analysis steps introduce technical variations that affect the peak areas of all molecules equally while others affect the peak areas of a subset of molecules with varying degrees. To correct these technical variations, some existing normalization methods simply scale the peak areas of all molecules detected …

Perceptions Of Pediatric Nurses And Parents Of Hospitalized Children Engaged In Shared Decision Making., Lisa English Long

Electronic Theses and Dissertations

Achievement of optimal quality in today’s healthcare environment practices means that clinical practices must be based on evidence. Evidence-based practice (EBP) is the integration of research findings, clinician expertise, and patient-centeredness that includes a focus on preferences and values (Melnyk & Fineout-Overholt, 2015). An area within EBP needing increased attention is the aspect of patient preferences and values. The process of Shared Decision Making (SDM) incorporates assessment of preferences and values within a process in which where patients, families and healthcare professionals collaborate to make decisions regarding patient care. The purpose of this study was to describe perceptions of parents …

Biophysical Exploration Of Conformational Environments In Zymogen Prothrombin And Blood Coagulant Thrombin., Ramya Billur

Electronic Theses and Dissertations

The serine protease thrombin plays important roles in coagulation, anticoagulation, and platelet activation. Thrombin is initially expressed as the inactive zymogen prothrombin (ProT). The final cleaved and activated form of thrombin has mature anion binding exosites (ABEs) and several regulatory loops. Engagement with these exosites helps define the fate of thrombin as a procoagulant or an anticoagulant. Researchers previously reported that zymogen ProT may already bind exosite ligands. Little is known about conformational changes associated with ProT maturation, resultant ligand binding affinities, individual ligand-protein contacts, and long-range communication between thrombin exosites. Protease Activated Receptors (PARs) play critical roles in controlling …