Digital Commons Network^™

Distribution Of A Sum Of Random Variables When The Sample Size Is A Poisson Distribution, Mark Pfister

Electronic Theses and Dissertations

A probability distribution is a statistical function that describes the probability of possible outcomes in an experiment or occurrence. There are many different probability distributions that give the probability of an event happening, given some sample size n. An important question in statistics is to determine the distribution of the sum of independent random variables when the sample size n is fixed. For example, it is known that the sum of n independent Bernoulli random variables with success probability p is a Binomial distribution with parameters n and p: However, this is not true when the sample size …

Developing Optimization Techniques For Logistical Tendering Using Reverse Combinatorial Auctions, Jennifer Kiser

Electronic Theses and Dissertations

In business-to-business logistical sourcing events, companies regularly use a bidding process known as tendering in the procurement of transportation services from third-party providers. Usually in the form of an auction involving a single buyer and one or more sellers, the buyer must make decisions regarding with which suppliers to partner and how to distribute the transportation lanes and volume among its suppliers; this is equivalent to solving the optimization problem commonly referred to as the Winner Determination Problem. In order to take into account the complexities inherent to the procurement problem, such as considering a supplier’s network, economies of scope, …

The Expected Number Of Patterns In A Random Generated Permutation On [N] = {1,2,...,N}, Evelyn Fokuoh

Electronic Theses and Dissertations

Previous work by Flaxman (2004) and Biers-Ariel et al. (2018) focused on the number of distinct words embedded in a string of words of length n. In this thesis, we will extend this work to permutations, focusing on the maximum number of distinct permutations contained in a permutation on [n] = {1,2,...,n} and on the expected number of distinct permutations contained in a random permutation on [n]. We further considered the problem where repetition of subsequences are as a result of the occurrence of (Type A and/or Type B) replications. Our method of enumerating the Type A replications causes double …

Hiv Integrase Inhibitor Pharmacogenetics And Clinical Outcomes: An Exploratory Association Study, Derek E. Murrell

Electronic Theses and Dissertations

As HIV is now primarily a chronic condition, treatment is given life-long with changes as necessitated by alterations in tolerability and efficacy. Thus, personalized medicine may be useful in the prevention of unnecessary drug exposure and avoidable side effects. Three of the four currently available HIV integrase strand transfer inhibitors (INSTIs), raltegravir, elvitegravir, and dolutegravir, are widely utilized antiretrovirals in the USA and exhibit variations in outcomes among subjects. To interrogate differences among subjects receiving these drugs, we investigated the association of several single nucleotide polymorphisms (SNPs) with drug exposure, clinical outcomes, and subject-reported adverse events. HIV+ adults (≥18 years …

Metabolic Plasticity In The Cellular Stress Response, Ying Li

Electronic Theses and Dissertations

Changes to the metabolism of the cardiomyocyte are driven by complex signaling pathways in order to adjust to stress. For instance, HIF-1α is classically known to upregulate glycolytic metabolism to compensate for oxygen deficiency. Other important effects upon glucose metabolism, which we investigate here more extensively, were also observed. Hearts derived from mice with the cardiac-restricted expression of a stabilized form of HIF-1α are remarkably ischemia stress-tolerant. Here, stable isotope-resolved metabolomic analyses were utilized to investigate glucose cardiometabolism remodeling by HIF-1αduring ischemia. We found that ¹³C-lactate accumulation was significantly elevated in HIF-1α expressing hearts while paradoxically glycogen was maintained …

Selecting The Most Effective Energy Modeling Tool Based On A Project Requirement, Sodiq Akande

Electronic Theses and Dissertations

Building energy usage can be derived and controlled by performing building energy modeling. BEM can be performed using numerous software tools such as DesignBuilder, OpenStudio, EnergyPlus etc. These modeling tools can be sorted into three different modeling categories: Black-box, Gray-box and White-box. It is important for a modeler to be able to quickly select the proper tool from the proper category to meet the need of the project. To validate the method of categorizing tools, the three models generated using tools from each category and the modeling outputs required were compared. Each model was designed to estimate the amount of …

Hydrolysis Of Cellulose And Biomass Using Blue Molybdenum, Farouk Awudu

Electronic Theses and Dissertations

Hydrolysis of cellulosic biomass is an important and ongoing subject of research due to generating precursors for biofuel synthesis. This work involves hydrolysis of microcrystalline cellulose and Arundo donax to glucose. Methods for acid hydrolysis include the use of sulfuric acid, phosphomolybdic acid, blue molybdenum using low concentrations at 40-100 °C. For comparison purposes, enzymatic hydrolysis was also carried out using cellulase. Products were quantified by measuring total organic carbon and reducible sugars using dinitrosalicylic acid. Use of phosphomolybdic acid, blue molybdenum and sulfuric acid even at 6.0 M did not increase the amount of glucose compared to using water …

An Assessment Of The Factors That Increase The Likeliness Of Hispanic Students To Attend Higher Education In Northeast Tennessee, Denise Chavez Reyes

Electronic Theses and Dissertations

From 2000 to 2014 the number of Hispanics grew 230%, representing an 8.6% of the national's youth (Tennessee Higher Education Commission, 2016). Although the population is growing, the educational attainment does not reflect this growth. This research tries to identify what factors influence individuals' decision to pursue higher education in rural Tennessee. Intrinsic (grit, hardiness, and motivation to lead) and extrinsic factors (Status in the U.S., caregivers’ education, involvement in high school and others) were explored. Sixty-six complete responses were submitted to our online survey. Hypothesis testing with Pearson chi-square, difference of means (ANOVA and two sample t-test), and correlational …

Examining Contributors To Preschoolers’ Classroom Engagement Using Structural Equation Modeling, Hongxia Zhao

Electronic Theses and Dissertations

The purpose of this study is to demonstrate whether and how teacher-child interactions, teacher-child relationships, children’s self-control, parents’ education levels, teachers’ teaching experience and education levels, and classroom physical environment impact children’s engagement levels. Preschoolers from Head Start programs and a university childcare center (N = 135, M = 54.93 months, SD = 7.50) and 15 preschool classroom teachers in East Tennessee participated in the study. Classroom head teachers rated child’s engagement, teacher-child interaction, teacher-child relationships, and children’s self-control using provided questionnaires. The primary researcher assessed the classroom physical environment and determined the reliability for the Children’s Physical Environments …

3d-Printed Fluidic Devices And Incorporated Graphite Electrodes For Electrochemical Immunoassay Of Biomarker Proteins, Abdulhameed Alabdulwaheed

Electronic Theses and Dissertations

Biomarkers are measurable indicators of health status or disease state that can be used for diagnosis and may help guide patient treatment strategies. Enzyme-linked immunosorbent assays (ELISA) and other many clinical techniques currently used for measuring biomarker proteins lack sensitivity, demand high analysis cost, are often not well-suited for measuring multiple biomarkers in a single sample, and require long analysis times. Here, we demonstrate simple, low-cost 3D-printed flow-through devices with integrated electrodes modified with gold nanoparticles (AuNPs) for electrochemical immunoassays of S100B, a biomarker protein related to conditions like skin cancer and brain injuries. Flow-through devices are fabricated from photocurable-resin …

Synthesis And Characterization Of Zinc(Ii) Dipyrrin Photosensitizers, Norah Alqahtani

Electronic Theses and Dissertations

Photocatalytic carbon dioxide reduction transforms CO2 to useful chemicals and fuels, reducing CO2 emissions and making fossil fuels more renewable. Due to a lack of earthabundant sensitizers, we want to design new earth-abundant sensitizers to go with the many known carbon dioxide reduction catalysts. Zn(II) dipyrrin complexes strongly absorb visible light, but their excited state properties have not been widely studied. To investigate their photophysical properties, two Zn dipyrrin complexes, with and without heavy atoms, were synthesized and characterized by NMR and mass spectrometry. The photophysical properties of the two complexes were measured in polar and non-polar solvents, particularly fluorescence …

School Library Access As Related To Student Reading Comprehension In An Urban East Tennessee School District, Lori Church

Electronic Theses and Dissertations

The purpose of this study was to explore the impact of school library access on student reading comprehension as measured by the Easy CBM universal screener test. The population consisted of 5^th and 6^th grade students enrolled in one intermediate school in an urban school system in East Tennessee. Data were analyzed for the population of the 2016-2017 academic school year. Specifically, this study considered the impact of school library access on students who qualify for free or reduced meals.

A quantitative study was used to find correlations and differences in the reading comprehension data and library checkout …

Effect Of Root Cause Analysis On Pre-Licensure, Senior-Level Nursing Students’ Safe Medication Administration Practices, Kristi Miller

Electronic Theses and Dissertations

Aim: The aim of this study was to examine if student nurse participation in root cause analysis has the potential to reduce harm to patients from medication errors by increasing student nurse sensitivity to signal and responder bias.

Background: Schools of nursing have traditionally relied on strategies that focus on individual characteristics and responsibility to prevent harm to patients. The modern patient safety movement encourages utilization of systems theory strategies like Root Cause Analysis (RCA). The Patient Risk Detection Theory (Despins, Scott-Cawiezell, & Rouder, 2010) supports the use of nurse training to reduce harm to patients.

Method. Descriptive and …

An Investigation Into Fatigue Management: Effects Of Two Different Loading Protocols On Markers Of Inflammation And The Endocrine Response, Jake Bernards

Electronic Theses and Dissertations

The purposes of this dissertation were to 1) determine the effectiveness of the neutrophillymphocyte ratio (NLR) as an athlete monitoring tool in resistance training and 2) determine if repetition maximum or relative intensity loading scheme is superior in managing fatigue through the hormonal, inflammatory, and performances response throughout a 10-week periodized resistance training program. Results from the dissertation give merit to continued research regarding the use of NLR as a monitoring tool to help determine the degree of recovery. Furthermore, results from this dissertation lead to questioning the effectiveness of using a repetition maximum (RM) loading scheme within a periodized …

Pre-Kindergarten And Kindergarten Teachers' Perceptions Of The Student Growth Portfolio Model In Tennessee, Amanda Pickens

Electronic Theses and Dissertations

The focus of this quantitative study was to discover perceptions of pre-K and kindergarten teachers within public schools in Tennessee regarding the appropriateness of the student growth portfolio model. This study explored teachers’ perceptions of the appropriateness of the math standards, English language arts standards, and the scoring guide included within the SGPM. A quantitative survey was used to understand pre-K and kindergarten teachers’ perceptions of the appropriateness of the 2017-2018 student growth portfolio model. There were 16 pre-K teachers and 51 kindergarten teachers who participated in the survey. Single sample t-tests were used to analyze responses. Research indicated that …

Factors And Circumstances Related To Teacher Retention In Rural, High Poverty Districts In South Carolina, Neal Vincent

Electronic Theses and Dissertations

According to the literature related to teacher retention in rural, high poverty districts, South Carolina researchers are predicting a major shortage of teachers based on the number of college students enrolled in education majors. Another area of concern is the retention of teachers in high poverty districts and schools. A qualitative study was therefore conducted to investigate the factors and circumstances related to teacher retention in rural, high poverty, South Carolina districts. Specifically, data was collected and analyzed to determine why long-serving teachers have remained in the same district for at least four years instead of transferring or leaving the …

Fascicle Arrangement In College-Aged Athletes, Jacob Goodin

Electronic Theses and Dissertations

Purpose: To compare muscle architecture variables between sport and sex in competitive athletes, and to compare muscle architecture with performance variables in strong versus weak athletes, and good versus poor jumpers. Methods: The vastus lateralis (VL) and lateral gastrocnemius (LG) muscles of 139 collegiate athletes were collected using ultrasonography to determine muscle thickness (MT), pennation angle (PA), fascicle length (FL), and relative fascicle length (FL_rel). Absolute and relative peak power, absolute and relative isometric peak force, and jump height were measured in a subset of baseball and soccer athletes. A 5x2 factorial analysis of variance (ANOVA) was used …

Determinants Of Well-Being Among Military Caregivers, Ludwig Marcello Martinez

Electronic Theses and Dissertations

Although the current body of research in the field of informal caregivers is extensive, this research focuses on the experiences of civilian caregivers. This focus contributes to limited knowledge regarding factors that influence the experiences of individuals who provide care to ill and/or wounded service members. Although limited, this research suggests that military caregivers often experience higher levels of distress when compared to the national average. The present study aimed to examine the relationship between the veteran’s level of disability and dyadic stress on the military caregiver’s overall sense of well-being. Additionally, this study examined the moderating effects of attachment …

Relationship Variables In Group Psychotherapy Treatment For Sexual Trauma Survivors, Sarah Gooch

Electronic Theses and Dissertations

In the aftermath of sexual trauma, many survivors face painful emotions and experiences that impact their mental health and relationships. This study examined relational group psychotherapy processes including group cohesion and bond with the group leaders as vital components in treatment for sexual trauma survivors. The construct of shame was highlighted and the relationship between shame and group cohesion was explored. Outcome measures were used to assess PTSD symptomatology. A repeated-measures design was used to assess groups that were currently occurring in the community for adult, female survivors of sexual trauma. Five treatment groups were evaluated, with 27 members consenting …

Examining The Clinical Prediction Of Cohesion In Group Psychotherapy And Potential Moderators, Ron Dolgin

Electronic Theses and Dissertations

Group cohesion, or the way in which group members relate and work toward the primary task of a therapy group, is a predictor for positive outcome in group psychotherapy and the building block for most group development models. Research has shown that interventions are most effective when tailored for the developmental stage of the group (Burlingame, Fuhriman, & Johnson, 2001). Logic follows that if best practice dictates that interventions be implemented based on developmental stage which, in turn, is largely informed by group cohesion, then group leaders should be competent in accurately assessing the cohesion of the group. To date, …

Three Studies Examining The Effects Of Business Analytics On Judgment And Decision Making In Accounting, Bradley Lang

Electronic Theses and Dissertations

This dissertation consists of three studies investigating the relationship between business analytics and decision making in accounting. In an effort to improve performance, organizations increasingly emphasize fact-based decision making supported by business analytics, which translate complex data into manageable information through statistical analysis. While the recent focus on business analytics is transforming how managers make decisions, analytics alone do not generate increased performance; the synergy between business analytics and user judgments is a vital component of realizing value. To this end, Study I experimentally investigates how various characteristics of business analytics affect individuals' reliance and perceptions of the analytic. Through …

Preparing For A National Weightlifting Championship: A Case Series, Spencer K. Travis

Electronic Theses and Dissertations

The purpose of this thesis was to observe psychological, physiological, and performance changes to determine when two high-level weightlifters were peaked for a major competition. We addressed this purpose by conducting a two-part case study series with one USA international level female and one USA national level male weightlifter. Both athletes were considered to be peaked on competition day. The results support our hypothesis that jumping performance would be peaked on competition day corresponding with an increased recovery and decreased stress state. However, contrary to our hypothesis, each athlete exhibited small decreases in muscle size leading into the competition relative …

Clustering Mixed Data: An Extension Of The Gower Coefficient With Weighted L2 Distance, Augustine Oppong

Electronic Theses and Dissertations

Sorting out data into partitions is increasing becoming complex as the constituents of data is growing outward everyday. Mixed data comprises continuous, categorical, directional functional and other types of variables. Clustering mixed data is based on special dissimilarities of the variables. Some data types may influence the clustering solution. Assigning appropriate weight to the functional data may improve the performance of the clustering algorithm. In this paper we use the extension of the Gower coefficient with judciously chosen weight for the L2 to cluster mixed data.The benefits of weighting are demonstrated both in in applications to the Buoy data set …

Native American Occupation Of The Singer-Hieronymus Site Complex: Developing Site History By Integrating Remote Sensing And Archaeological Excavation, Claiborne Sea

Electronic Theses and Dissertations

Located on a ridgetop in central Kentucky, the Singer-Hieronymus Site Complex consists of at least four Native American villages. The Native Americans who lived there are called the “Fort Ancient” by archaeologists. This study examined relationships between these villages, both spatially and temporally, to build a more complete history of site occupation. To do this, aerial imagery analysis, geophysical survey, and archaeological investigations were conducted. This research determined there were differences among villages in terms of their size, however other characteristics—internal village organization, village shape, radiometric dates, and material culture—overlapped significantly. Additionally, landscape-scale geophysical survey identified at least three potentially …

School Climate: A Comparison Of Teachers, Students, And Parents, James A. Jacobs

Electronic Theses and Dissertations

This study was designed to examine the benefits of positive school climate and to measure the perceptions of school climate for intermediate grades in a Northeast Tennessee School district. An online school climate survey was used to collect responses from participants in intermediate grades and focused on the 3 major components of school climate: school engagement, school environment, and school safety. Data were collected for 2 consecutive years in 2016-2017 and 2017-2018. Response totals included 1,955 student responses, 116 teacher responses, and 210 parent responses that were analyzed and used for this study. Of the student totals, some students that …

Post-Transcriptional Regulation Of Rsma In Pseudomonas Aeruginosa, Ian Miller

Electronic Theses and Dissertations

Pseudomonas aeruginosa is a Gram-negative bacillus found in numerous environments. Gene regulatory mechanisms such as; Two-Component Systems, transcriptional and post-transcriptional regulators, and small non-coding RNAs control the expression of virulence factors that allow P. aeruginosa to initiate acute infections and persist as a chronic infection. A significant post-transcriptional regulator involved in these regulatory networks is the Regulator of Secondary Metabolites (RsmA). In this study, we investigated the contribution of a putative stem-loop on expression of RsmA. We constructed rsmA leader fusions to measure translation with and without the stem-loop present. Secondly, we introduced point mutations to disrupt the formation …

The State Of Outdoor Education In Northeast Tennessee: Preschool Teacher Attitudes Toward Outdoor Education, Cathy Landy

Electronic Theses and Dissertations

The purpose of this study was to investigate the state of outdoor education in preschool classrooms in Northeast Tennessee, with a specific focus on preschool teachers’ attitudes toward outdoor education. This comparative, mixed-methods study focused in part on teachers’ current beliefs about outdoor education, how they use the outdoor environment, and whether their attitudes influence their lesson planning for outdoor education. Participants were preschool teachers in public, private, church-affiliated, and Head Start preschools in 4 counties in northeast Tennessee. The study sample consisted of 81 participants (80 female; 1 male). Ages ranged from 20-65 years (M = 40.76). The …

Novel Relative Spontaneous Ignition Temperature Determination Using Carbon Dioxide Onset With Sta/Ir, Antonio David Trevino

Electronic Theses and Dissertations

Simultaneous thermal analysis, coupled with infrared spectroscopy (STA/IR), was utilized to monitor the evolution of gaseous products during the thermal degradation of samples from Triadica sebifera (Chinese tallow), Ligustrum sinense (Chinese privet), and Ilex vomitoria (yaupon) plants. Identification of carbon dioxide was successful with a spectral match of 90.2 percent and further used in the determination of relative spontaneous ignition temperature, or RSIT. The RSIT value during the growing season for Chinese tallow, Chinese tallow stem, Chinese privet, and Yaupon were 208.4°C, 250.3°C, 210.1°C, and 232.3°C respectively. During the dormant seasons, the values for Chinese tallow stem, Chinese privet, and …

Design Guidelines: A Practical Guide To Preserving The Historic, Cultural, And Architectural Heritage Of Gladewater, Texas, Conor Herterich

Electronic Theses and Dissertations

In October of 1930, Columbus Marion Joiner’s oil rig, “Daisy Bradford No. 3,” blew a gusher of oil high into the East Texas sky. The subsequent storm of economic activity that resulted from the discovery of the East Texas oilfield irrevocably changed the built environment of many small towns in the region, including Gladewater, Texas. Oil money that flowed into the city funded a flurry of building projects in the 1930s and 1940s that left an indelible mark on the landscape of Gladewater’s downtown area. Unfortunately, a lack of oversight, planning, and guidance has since led to the deterioration of …

I Cut Off My... Voice: An Autoethnography Of An Artist And Art Educator With A Brca Genetic Mutation, Nicki Lynn Hornbaker

Electronic Theses and Dissertations

The effects of BRCA genetic mutations on artists and art educators had not been known. Autoethnography is a qualitative method for writing about personal experiences through a cultural lens. I used my personal experiences within a BRCA positive community to understand shared experiences among artists and art educators with this genetic mutation. This study aimed to explore the commonalities that are occurring within this subgroup. Anxiety and emotional stress played a role in most of the respondents‟ lives, affecting them in numerous ways. Most of the respondents underwent salpingectomy, oophorectomy, and mastectomy surgeries which led to further emotional and physical …