Open Access. Powered by Scholars. Published by Universities.®
- Discipline
-
- Social and Behavioral Sciences (5476)
- Education (4376)
- Engineering (4148)
- Physical Sciences and Mathematics (3531)
- Arts and Humanities (3496)
-
- Life Sciences (3161)
- Medicine and Health Sciences (2239)
- Psychology (1660)
- Electrical and Computer Engineering (1170)
- Educational Leadership (1083)
- Sociology (973)
- Educational Administration and Supervision (791)
- Chemistry (781)
- History (716)
- Civil and Environmental Engineering (663)
- Communication (653)
- Mechanical Engineering (647)
- Biology (633)
- Environmental Sciences (627)
- Physics (618)
- Computer Sciences (567)
- Higher Education (552)
- Business (546)
- Animal Sciences (502)
- Biochemistry, Biophysics, and Structural Biology (488)
- Curriculum and Instruction (479)
- Public Affairs, Public Policy and Public Administration (453)
- Teacher Education and Professional Development (448)
- Clinical Psychology (440)
- Educational Assessment, Evaluation, and Research (429)
- Institution
-
- University of Mississippi (8605)
- University of Central Florida (6833)
- South Dakota State University (4806)
- University of Louisville (4691)
- East Tennessee State University (3781)
-
- University of Denver (2609)
- Duquesne University (2246)
- Abilene Christian University (1048)
- Stephen F. Austin State University (675)
- Coastal Carolina University (202)
- Xavier University of Louisiana (153)
- University of Health Sciences and Pharmacy in St. Louis (3)
- University of Memphis (2)
- Georgia Southern University (1)
- Keyword
-
- Morgridge College of Education (709)
- College of Arts Humanities and Social Sciences (657)
- Education (606)
- Daniel Felix Ritchie School of Engineering and Computer Science (397)
- College of Natural Science and Mathematics (259)
-
- Gender (212)
- Higher education (205)
- School administration (200)
- Josef Korbel School of International Studies (197)
- Leadership (188)
- Teaching and Learning Sciences (167)
- Psychology (164)
- Identity (151)
- Retention (150)
- Communication (143)
- Phenomenology (140)
- Women (135)
- Joint Ph.D. Program in Study of Religion (132)
- Race (127)
- Depression (124)
- Curriculum and Instruction (121)
- Mathematics (121)
- Technology (120)
- Machine learning (118)
- Stress (117)
- Simulation (114)
- Higher Education (110)
- Performance (109)
- Anthropology (105)
- Religion (104)
- Publication Year
- File Type
Articles 8251 - 8280 of 35655
Full-Text Articles in Entire DC Network
Characterizing Spatiotemporal Patterns Of White Mold In Soybean Across South Dakota Using Remote Sensing, Confiance L. Mfuka
Characterizing Spatiotemporal Patterns Of White Mold In Soybean Across South Dakota Using Remote Sensing, Confiance L. Mfuka
Electronic Theses and Dissertations
Soybean is among the most important crops, cultivated primarily for beans, which are used for food, feed, and biofuel. According to FAO, the United States was the biggest soybeans producer in 2016. The main soybean producing regions in the United States are the Corn Belt and the lower Mississippi Valley. Despite its importance, soybean production is reduced by several diseases, among which Sclerotinia stem rot, also known as white mold, a fungal disease that is caused by the fungus Sclerotinia sclerotiorum is among the top 10 soybean diseases. The disease may attack several plants and considerably reduce yield. According to …
Evaluation Of Feeding Alternative Feedstuffs Including Hydroponic Barley Sprouts And Carinata Meal To Dairy Cattle, Rhea D. Lawrence
Evaluation Of Feeding Alternative Feedstuffs Including Hydroponic Barley Sprouts And Carinata Meal To Dairy Cattle, Rhea D. Lawrence
Electronic Theses and Dissertations
The purpose of this dissertation research was to examine alternative feed ingredients not typically found in dairy cattle diets. In total, four studies were conducted to evaluate feedstuffs such as hydroponic barley sprouts and carinata meal and how they affect cattle performance. To determine how feeding hydroponic barley sprouts would affect growing dairy heifer and lactating cow performance two feeding studies were conducted. In the first study, inclusion of 14 % (DM basis) hydroponic barley sprouts (HYD) was evaluated in an ad libitum total mixed ration (TMR) compared to a control (CON) diet on dairy heifer performance during a 12 …
Effects Of Increasing Dietary Levels Of Carinata Meal On Feeding Behavior, Performance And Carcass Characteristics Of Beef Growing Steers, Alejandro C. Casella
Effects Of Increasing Dietary Levels Of Carinata Meal On Feeding Behavior, Performance And Carcass Characteristics Of Beef Growing Steers, Alejandro C. Casella
Electronic Theses and Dissertations
The objectives of the present study are to evaluate feeding behavior, animal performance and carcass characteristics of beef growing steers fed increasing amounts of carinata meal (CM). Due to the high protein content of the CM after the oil extraction for biofuel there is an opportunity to use it as a protein supplementation in beef cattle. Twenty-four steers blocked by weight were assigned to four corn-based diets (n = 6 animals per treatment). In the three treatment diets, carinata meal replaced high-moisture corn at 5, 10, or 15%. The diets were fed using the Insentec RIC system for 138 days. …
Nutritional Transporter Mediated Drug Delivery For Cancer, Siddharth S. Kesharwani
Nutritional Transporter Mediated Drug Delivery For Cancer, Siddharth S. Kesharwani
Electronic Theses and Dissertations
Recent advancements in nanotechnology have unfolded novel opportunities in medicine, especially in targeted therapeutics and imaging for cancer. However, the majority of the existing nanotechnologies for cancer suffer from shortcomings such as (i) rapid elimination from the systemic circulation before reaching the cancer tissue. (ii) poor tumor accumulation, targeting, and penetration due to inadequate vasculature and extensive extracellular matrix in the tumor. Thus, overcoming these two limitations of nanotechnology is of considerable interests for cancer researchers. In this dissertation, we demonstrate the feasibility of glucose-modified nanoparticles (GLU-NPs) as an efficient cancer targeted-delivery system for enhancing the systemic circulation time and …
Classification Of North Africa For Use As An Extended Pseudo Invariant Calibration Sites (Epics) For Radiometric Calibration And Stability Monitoring Of Optical Satellite Sensors, Mahesh Shrestha
Electronic Theses and Dissertations
An increasing number of Earth-observing satellite sensors are being launched to meet the insatiable demand for timely and accurate data to help the understanding of the Earth’s complex systems and to monitor significant changes to them. The quality of data recorded by these sensors is a primary concern, as it critically depends on accurate radiometric calibration for each sensor. Pseudo Invariant Calibration Sites (PICS) have been extensively used for radiometric calibration and temporal stability monitoring of optical satellite sensors. Due to limited knowledge about the radiometric stability of North Africa, only a limited number of sites in the region are …
A Dynamic Fault Tolerance Model For Microservices Architecture, Hajar Hameed Addeen
A Dynamic Fault Tolerance Model For Microservices Architecture, Hajar Hameed Addeen
Electronic Theses and Dissertations
Microservices architecture is popular for its distributive system styles due to the independent character of each of the services in the architecture. Microservices are built to be single and each service has its running process and interconnecting with a lightweight mechanism that called application programming interface (API). The interaction through microservices needs to communicate internally. Microservices are a service that is likely to become unreachable to its consumers because, in any distributed setup, communication will fail on occasions due to the number of messages passing between services. Failures can occur when the networks are unreliable, and thus the connections can …
An Initial Exploration Of The 2005 Iowa Rural Interstate Speed Limit Increase Using Linear Regression, Thomas Ryan Cook
An Initial Exploration Of The 2005 Iowa Rural Interstate Speed Limit Increase Using Linear Regression, Thomas Ryan Cook
Electronic Theses and Dissertations
Speed limit increases, particularly on interstates have been studied and researched many times over the course of the last 50 years in the United States. These research efforts began after the implementation of the National Maximum Speed Law (NMSL), which reduced all speed limits to a maximum of 55-mph. In the years that followed, this restriction was relaxed to 65-mph with the Surface Transportation and Uniform Relocation Assistance Act (STURAA) and ultimately repealed later by the National Highway System Designation Act (NHSDA). Since the repeal, states reacted in myriad of ways and many studies documented the changes of those reactions. …
Reducing The Large Class Code Smell By Applying Design Patterns, Bayan Turkistani
Reducing The Large Class Code Smell By Applying Design Patterns, Bayan Turkistani
Electronic Theses and Dissertations
Software systems need continuous developing to cope and keep up with everchanging requirements. Source code quality affects the software development costs. In software refactoring object-oriented systems, Large Class, in particular, hinder the maintenance of a system by letting it difficult for software developers to understand and perform modifications. Also, it is making the development process labor-intensive and time-wasting. Reducing the Large Class code smell by applying design patterns can make the refactoring process more manageable, ease developing the system and decrease the effort required for the maintaining of software. To guarantee object-oriented software stays clear to read, understand and modify …
Machine Learning For Load Profile Data Analytics And Short-Term Load Forecasting, Md. Rashedul Haq
Machine Learning For Load Profile Data Analytics And Short-Term Load Forecasting, Md. Rashedul Haq
Electronic Theses and Dissertations
Short-term load forecasting (STLF) is a key issue for the operation and dispatch of day ahead energy market. It is a prerequisite for the economic operation of power systems and the basis of dispatching and making startup-shutdown plans, which plays a key role in the automatic control of power systems. Accurate power load forecasting not only help users choose a more appropriate electricity consumption scheme and reduces a lot of electric cost expenditure but also is conducive to optimizing the resources of power systems. This advantage helps while improving equipment utilization for reducing the production cost and improving the economic …
Alternative Treatment Options For Controlling Anthelmintic-Resistant Haemonchus Contortus Populations In South Dakota Sheep Herds, Adam Sarah
Electronic Theses and Dissertations
Haemonchus contortus is a common economically important gastrointestinal nematode that obliges the survival and productivity of small ruminants, especially sheep and goats. Anthelmintic resistance is a primary challenge in ruminant health management programs in preventing and controlling the H. contortus populations; therefore, there is a great necessity in finding and developing natural plant products for use as alternatives to commercial anthelmintics for controlling H. contortus in pastured sheep and goats. This dissertation has three major aims conducted in three separate studies: the first in vivo one was to evaluate the extended effect of a springtime, combined-treatment with 3 anthelmintics having …
Application Of Analytical Techniques In Food Product Development, Sonali R. Pandey
Application Of Analytical Techniques In Food Product Development, Sonali R. Pandey
Electronic Theses and Dissertations
Products are analyzed in major sectors of food industry to meet regulatory standards, food safety, quality control, and research and development. Analytical and extraction techniques have been applied for simultaneous investigation of multiple product characteristics. Food analysis faces critical challenges due to the complex composition of food, leading to matrix effects that result in loss of accuracy and reliability. The analytical techniques require an efficient sample preparation to avoid or minimize matrix effects. Solid-phase extraction has been widely used to address this issue. In this dissertation, the aim is to apply analytical techniques in food product development. To accomplish this, …
Performance Differences Between Two Groups Of Commercial Pigs Following Experimental Infection With Prrs Virus 1-7-4, Erin Little
Performance Differences Between Two Groups Of Commercial Pigs Following Experimental Infection With Prrs Virus 1-7-4, Erin Little
Electronic Theses and Dissertations
Porcine reproductive and respiratory syndrome virus (PRRSV) is the costliest swine disease in North America. Vaccines and management alone have not been effective in controlling this disease. Genetic selection for resilience may be a complimentary approach for controlling PRRSV. The objective of this study was to estimate performance differences between two groups of pigs from the same commercial line following infection with PRRSV 1-7-4: 1) pigs sired by boars selected based on a standard index (TN-S), which emphasized feed efficiency and carcass quality; and 2) pigs sired by boars selected based on an experimental index (TN-E), which emphasized feed intake, …
Winter Snow Depth In Arctic Alaska Results In Complex Changes In Caribou Forage Quality, Jessica C. Richert
Winter Snow Depth In Arctic Alaska Results In Complex Changes In Caribou Forage Quality, Jessica C. Richert
Electronic Theses and Dissertations
Caribou (Rangifer tarandus) rely on the short growing season for much of their annual nutrition, making them susceptible to even small changes in forage quantity and quality. Body condition in the summer and fall is linked to winter survival rates and fecundity in cows, critical factors in the robustness of caribou populations. Due to a warmer, wetter climate, snowfall is predicted to increase over Alaska’s North Slope in the next several decades. Deeper snow results in higher soil temperatures, allowing microbial mineralization of nitrogen to continue throughout the winter and increasing the availability of nitrogen for plants in spring and …
Rumen Microbial Culture Library And In Vitro Analysis Of Selected Bacterial Species On Colonization Resistance Against Bovine Enteric Pathogens, Maria Antony
Electronic Theses and Dissertations
The anaerobic habitat of the four chambers in ruminant’s foregut plays a vital role in the fermentation of the food by the active involvement of the residing microbial community. The cultivability and the potential role of rumen bacteria in the field of livestock production, host health and immunity are important to study. The developed anaerobic culturing techniques enable us to culture and screen different rumen bacteria to study the anti-pathogenic effects. Whole genome sequencing and analysis help us to understand the genome level characteristics of the rumen bacterial species individually. Since the majority of the rumen biosphere is still not …
Finite Mixture Of Regression Models For Complex Survey Data, Abdelbaset Abdalla
Finite Mixture Of Regression Models For Complex Survey Data, Abdelbaset Abdalla
Electronic Theses and Dissertations
Over time, survey data has become an essential source of information for modern society. However, to be effective, the structures of survey data require sampling designs that are more complex than simple random sampling. The complex sampling data collected from enormous national surveys via these complex designs ideally include sample weights that allow analysis to take account of complicated population structures. When the target of inference is the parameters of a regression model, it is crucial to know whether these weights should be incorporated into the sampling weight when fitting the model to the survey data. The finite mixture models …
Methods For Earth-Observing Satellite Surface Reflectance Validation, Moe Talal Badawi
Methods For Earth-Observing Satellite Surface Reflectance Validation, Moe Talal Badawi
Electronic Theses and Dissertations
In this study an initial validation of the Landsat 8 (L8) Operational Land Imager (OLI) Surface Reflectance (SR) product was performed. The OLI SR product is derived from the L8 Top-of-Atmosphere product via the Landsat Surface Reflectance Code (LaSRC) software and generated by the U.S. Geological Survey (USGS) Earth Resources Observation and Science (EROS) Center. The goal of this study is to develop and evaluate proper validation methodology for the OLI L2 SR product. Validation was performed using near-simultaneous ground truth SR measurements during Landsat 8 overpasses at 13 sites located in the U.S., Brazil, Chile and France. The ground …
How Are Interannual Variations Of Land Surface Phenology In The Highland Pastures Of Kyrgyzstan Modulated By Terrain, Snow Cover Seasonality, And Climate Oscillations? An Investigation Using Multi-Source Remote Sensing Data, Monika Anna Tomaszewska
How Are Interannual Variations Of Land Surface Phenology In The Highland Pastures Of Kyrgyzstan Modulated By Terrain, Snow Cover Seasonality, And Climate Oscillations? An Investigation Using Multi-Source Remote Sensing Data, Monika Anna Tomaszewska
Electronic Theses and Dissertations
In the semiarid, continental climates of montane Central Asia, with its constant moisture deficit and low relative humidity, agropastoralism constitutes the foundation of the rural economy. In Kyrgyzstan, an impoverished, landlocked republic in Central Asia, herders of the highlands practice vertical transhumance—the annual movement of livestock to higher elevation pastures to take advantage of seasonally available forage resources. Dependency on pasture resource availability during the short mountain growing season makes herds and herders susceptible to changing weather and climate patterns. This dissertation focuses on using remote sensing observations over the highland pastures in Kyrgyzstan to address five interrelated topics: (i) …
Searching For A Sense Of Place: The Process Of How Adolescent Girls Overcome Suicidality, Tamara Keefner
Searching For A Sense Of Place: The Process Of How Adolescent Girls Overcome Suicidality, Tamara Keefner
Electronic Theses and Dissertations
Suicide and self-harming behaviors are significant public health problems among children and adolescents globally and in the United States. Despite significant advances in recent decades to understand, prevent, and treat childhood and adolescent self-harming and suicide, suicide rates remain high. Since the National Action Alliance for Suicide Prevention set a goal to reduce suicide deaths and attempts by 40% by 2020, there has been a paradigm shift in the study of suicide yielding significant advances in the understanding of suicide and other forms of self-inflicted injury. This dissertation highlights some of the new developments in the study of suicide. First, …
Sunflower Pollinators In South Dakota: An Evaluation Of Species Composition, Abundance And Influence On Yield, Mackenzie Mattern
Sunflower Pollinators In South Dakota: An Evaluation Of Species Composition, Abundance And Influence On Yield, Mackenzie Mattern
Electronic Theses and Dissertations
In 2017 and 2018, South Dakota was the largest producer of sunflowers, Helianthus annuus L. (Asterales: Asteraceae) in the US, grossing approximately $178 million per year. In South Dakota, both confection and oilseed sunflower cultivars are grown. Despite breeding efforts to increase sunflower's ability to self-pollinate there is evidence that pollinator visitation results in increased sunflower yields. In addition, there is evidence that sunflower pollen is beneficial for pathogen resistance in various bee species, suggesting the importance of a mutualistic relationship between pollinators and sunflowers. In some areas, observed increases in sunflower yield is attributed to the presence of Apis …
The Impacts Of Land Use And Land Cover Change On Water Quality In The Big Sioux River: 2007-2016, Dinesh Shrestha
The Impacts Of Land Use And Land Cover Change On Water Quality In The Big Sioux River: 2007-2016, Dinesh Shrestha
Electronic Theses and Dissertations
Between 2006 and 2012, conversion of 485,000 acres of grassland to cropland in eastern South Dakota was reported. In 2012, the Big Sioux River (BSR) running through most of eastern South Dakota was listed among the dirtiest rivers in the nation. This rating convinced state authorities to study trends of land cover changes in the BSR watershed and its association with BSR water quality with respect to increases in nitrate levels. This research i) quantifies spatial and temporal changes in the land cover types within the BSR watershed, and ii) identifies any correlation between these changes and changes in BSR …
Development Of A Neural Network-Based Object Detection For Multirotor Target Tracking, Spencer Harwood
Development Of A Neural Network-Based Object Detection For Multirotor Target Tracking, Spencer Harwood
Electronic Theses and Dissertations
Unmanned aerial vehicles (UAVs) have, for the past few decades, seen an increased popularity in industry and research centres. Despite this intense utilization by both markets there exists an active demand for the development of autonomous guidance, navigation, and control strategies. One need relates to the achievement of a high level of autonomy to identify and track a target object. An elective technique for this set of tasks is neural networks. In the development and study of these networks there is a distinct lack of substantive validation techniques to qualify network performances when implemented in a multirotor UAV. This thesis …
The Role Of A Community Coach In Rural Food Councils In Six Midwestern States, Kaitlyn Tusha
The Role Of A Community Coach In Rural Food Councils In Six Midwestern States, Kaitlyn Tusha
Electronic Theses and Dissertations
Objective: To quantitatively assess perceived coaching confidence of a community coach working with food councils, and to qualitatively determine perceived barriers and facilitators associated with coaching rural food councils.
Design: Two phases were implemented using a mixed methods study design with quantitative (scorecard) and qualitative (key informant interviews) methodologies.
Setting: Six rural, Midwestern states implementing Voices for Food.
Participants: Voices for Food community coaches (n=9) who coached rural food council(s).
Intervention: A component of the broader Voices for Food intervention.
Analysis: Quantitative scorecard data were analyzed with STATA by running paired ttests. Qualitative key information interview data were analyzed with …
The Relationship Between Campus Wellness Center Usage And Symptoms Of Depression In College Freshmen, Allison Leonard
The Relationship Between Campus Wellness Center Usage And Symptoms Of Depression In College Freshmen, Allison Leonard
Electronic Theses and Dissertations
There is limited research done on the relationship between the program utilization at a campus wellness facility and the symptoms of depression in college freshmen. College students have been found to have a higher prevalence of depressive symptoms than the general population, possibly due to the stressors college life can add. Studies have been done on the effects of physical activity as an intervention for depression as well as on the benefits of campus wellness facilities; however, there have been few studies that look at both campus recreation and depression. The author’s purpose for this study was to see if …
Energy Optimization And Coordination Frameworks For Smart Homes Considering Incentives From Discomfort And Market Analysis, Priti Paudyal
Energy Optimization And Coordination Frameworks For Smart Homes Considering Incentives From Discomfort And Market Analysis, Priti Paudyal
Electronic Theses and Dissertations
The electricity demand is increasing with the growing use of electricity-based appliances in today’s world. The residential sector’s electricity consumption share is also increasing. Demand response (DR) is a typical way to schedule consumers’ energy consumption and help utility to reduce the peak load demand. Residential demand management can contribute to reduce peak electric demand, decrease electricity costs, and maintain grid reliability. Though the demand management has benefits to the utility and the consumers, controlling the consumers electricity consumption provides inconvenience to the consumers. The challenge here is to properly address the customers’ inconvenience to encourage them to participate and …
Evaluation Of Effects Of Methods Used For Forage Analysis And Dietary Inclusion Of Buffer On Fiber Digestibility And Rumen Fermentation In Diets High In Distillers Grains, Lydia Kehinde Olagunju
Evaluation Of Effects Of Methods Used For Forage Analysis And Dietary Inclusion Of Buffer On Fiber Digestibility And Rumen Fermentation In Diets High In Distillers Grains, Lydia Kehinde Olagunju
Electronic Theses and Dissertations
Forage quality is an important factor affecting intake and utilization of forage, thus making it imperative to evaluate the methods used to determine the nutritive values of forage in order to predict animal performance. Additionally, fibrous feeds for ruminants are less subject to competitive demand. The plant cell wall is the largest hindrance to complete digestion of feeds, particularly forages and by-products and to the utilization of the nutrients and energy they contain, necessitating effective strategies for increasing the rate and efficiency of utilization of forage fiber and the energy therein. It is critically important to increase fiber digestion for …
The Impact Of Alcohol Consumption On Academic Success And Athletic Identity In Collegiate Student-Athletes, Zoe E. Arnold
The Impact Of Alcohol Consumption On Academic Success And Athletic Identity In Collegiate Student-Athletes, Zoe E. Arnold
Electronic Theses and Dissertations
Upon entering college in the United States, students are exposed to alcohol and, relatedly, the potentially dangerous experiences and effects that come with consuming alcohol. This is especially true for collegiate student-athletes, who have been found to have the highest consumption rate among student groups on campus. The purpose of the study was to understand the relationship between how student-athletes at a focus university, a Division I member of the National Collegiate Athletic Association, experience alcohol consumption, how their consumption affects their academic grade point average (GPA), and how athletic identity plays a role in their experiences. While the research …
Evaluation Of Flax Oil Supplementation On Performance Of Growing Dairy Heifer Calves And Lactating Cows, Chelsea Rose Schossow
Evaluation Of Flax Oil Supplementation On Performance Of Growing Dairy Heifer Calves And Lactating Cows, Chelsea Rose Schossow
Electronic Theses and Dissertations
Utilization of flax oil is new to the livestock industry, and limited research has been done to see the benefits of feeding the highly unsaturated oil to both dairy calves and lactating cows. Two studies were conducted to evaluate the potential benefits of flax oil as a lipid supplement. The first study compared the supplementation of two plant based oils to growing dairy calves. Thirty-six female Holstein calves in individual hutches were used in a 12-wk randomized complete block design study. Treatments were: 1) control (CON) with no oil, 2) 80 g/d of flax oil (FLAX), and 3) and 80 …
Escherichia Coli Removal From Stormwater Using Steel Chips Filter, Peng Dai
Escherichia Coli Removal From Stormwater Using Steel Chips Filter, Peng Dai
Electronic Theses and Dissertations
Media filtration has received increasing attention as an effective technology that can facilitate the removal of particles and dissolved pollutions in the stormwater. However, most traditional media filtration systems are generally ineffective in removing bacteria, causing pollution of groundwater and receiving surface water. In this study, recycled steel chips were evaluated as low-cost filter materials for bacterial removal from stormwater. Laboratory column experiments were conducted to evaluate the impact of steel chips particle size, flow rate, initial E.coli concentration, pH, natural organic matter (NOM), steady and intermittent flow on E.coli removal. The results showed that E.coli removal decreased from 99.4% …
Disease Resistance In Wheat And Its Relatives, Ethan James Andersen
Disease Resistance In Wheat And Its Relatives, Ethan James Andersen
Electronic Theses and Dissertations
Plants have evolved a complex defense system against pests and pathogens utilizing many types of receptors, signaling factors, and defense compounds to detect pathogen presence and respond effectively. Since many pathogens have evolved immunesuppressing effectors used to reduce plant resistance, plants have evolved a family of receptors that detect pathogenic effectors as a result of an evolutionary arms race. These receptors contain Nucleotide-Binding Site and Leucine-Rich Repeat domains and are called NBS-LRR or NLR proteins. Many grasses possess huge genomes with hundreds of NLR-encoding genes, often found in clusters at the extra-pericentromeric regions of chromosomes, where unequal crossing over causes …
Development Of A Novel Nanotechnology-Based Vaccine Adjuvant And Delivery System For Systemic And Mucosal Immunity, Mohammed Ali Bakkari
Development Of A Novel Nanotechnology-Based Vaccine Adjuvant And Delivery System For Systemic And Mucosal Immunity, Mohammed Ali Bakkari
Electronic Theses and Dissertations
Many serious infections for which there are no existing vaccines, enter by a mucosal route such as HIV, influenza, and tuberculosis, etc. Therefore, designing safe and effective mucosal vaccines that elicit robust immune response at mucosal sites is still a major challenge without a safe mucosal adjuvant. Previously, our laboratory had discovered inulin acetate as a novel toll-like-receptor-4 agonist (adjuvant). The study in this dissertation explored the application of nanoparticles prepared with inulin acetate (InAc-NPs) as a vaccine adjuvant and delivery system for enhancing mucosal immunity. The rationale behind selecting InAc-NPs is their proven ability to activate strong systemic immunity …