Digital Commons Network^™

Inhibition Of De Novo And The Prion-Like Spread Of Amyloidogenesis Using In Vitro And In Vivo Disease Models, Johnson Anazoba Joseph

Electronic Theses and Dissertations

The aberrant fibrous, extracellular, and intracellular proteinaceous deposits in cells, organs and tissues are referred to as amyloids. These deposits are dominated by β-sheet structures that have been implicated in several neurodegenerative diseases and cancer. In this work, the types of amyloidosis studied include Parkinson’s disease (PD) using UA196 and NL5901 strains of Caenorhabditis elegans (C. elegans), Alzheimer’s disease (AD) using GMC101 strain of C. elegans, and cancer-associated mutant p53 aggregation in MIA PaCa-2 mutant cells. Several molecules including SK-129, NS132, NS163, bexarotene, a polyphenol (-)-epi-gallocatechine gallate (EGCG), ADH40, RD148, and RD242 were screened in vitro and in …

Socioeconomic Factors And Mass Shootings, 1982-2016, Taylor Petkovich

Electronic Theses and Dissertations

This paper is an examination and investigation of the relationship between socioeconomic factors and mass shootings. The objective of this paper was to see if economic policy making could be an effective tool for reducing the level of mass gun violence that America has been experiencing. This paper highlights the known relationship between violent crime and economics and tries to bridge that connection to mass shootings specifically through literature review and econometric testing. The ultimate takeaway from this paper’s results and analysis is the need for a universal definition and governing body for data on mass shootings in order to …

Working Here, There, And Everyware: The Impact Of Virtual Work On Employee Belonging, Martha Davis

Electronic Theses and Dissertations

Globalization, improvements in information and communications technologies, and the COVID-19 outbreak have increased the prevalence of virtual work arrangements. This change in the workforce presents both opportunities and challenges to employees and their organizations, transforming how organizations operate and how workers interact with each other. This shift to more virtual work has a high likelihood of impacting other fundamental human motivations, such as the need to belong, which has significant implications for an employee’s well-being and the broader organization’s health. This study asks the question: How do collaborative technologies impact virtual employee belonging? The study proposes a conceptual framework of …

Directly Polymerizable Co Releasing Molecules, Jackson Snow

Electronic Theses and Dissertations

Despite the commonly held consensus that carbon monoxide (CO) is toxic, it has been shown to be an essential signaling molecule in the human neuronal system and has been noted to have anti-inflammatory properties, act as a vasodilator, have anti-proliferative impacts on tumors, and many other beneficial effects. The current limitation to using CO as a therapeutic molecule is delivering the proper dosages using CO releasing molecules (CORMs) without exhibiting toxicity. The first chapter of this thesis will review the biological significance of CO in biological systems, the limitations of existing CORMs, and the properties of diphenylcyclopropenone (DPCP) that make …

Lipophilic Probes For Cellular Ethylene Detection, Morgan R. Brown

Electronic Theses and Dissertations

The structure of ethylene is simple, yet its biological effects are significant. When considering its role in biology it is almost exclusively regarded as a plant hormone. Research on ethylene from plants was progressed by several advancements in analytical instrumentation, from its discovery to elucidation of its signaling pathway. There is currently limited understanding of ethylene’s role in mammals, but evidence suggests that it may be a biomarker for oxidative stress! Additional tools and technology are crucial to study this surprising and important signaling role in mammals. Our group has developed molecular ethylene probes as a strategy to detect ethylene …

Frequency Analysis Of Trabecular Bone Structure, Daniel Parada San Martin

Electronic Theses and Dissertations

Medical data is hard to obtain due to privacy laws making research difficult. Many databases of medical data have been compiled over the years and are available to the scientific community. These databases are not comprehensive and lack many clinical conditions. Certain type of medical conditions are rare, making them harder to obtain, or are not present at all in the aforementioned databases. Due to the sparsity or complete lack of data regarding certain conditions, research has stifled. Recent developments in machine learning and generative neural networks have made it possible to generate realistic data that can overcome the lack …

Humanizing Computational Literature Analysis Through Art-Based Visualizations, Alexandria Leto

Electronic Theses and Dissertations

Inequalities in gender representation and characterization in fictional works are issues that have long been discussed by social scientists. This work addresses these inequalities with two interrelated components. First, it contributes a sentiment and word frequency analysis task focused on gender-specific nouns and pronouns in 15,000 fictional works taken from the online library, Project Gutenberg. This analysis allows for both quantifying and offering further insight on the nature of this disparity in gender representation. Then, the outcomes of the analysis are harnessed to explore novel data visualization formats using computational and studio art techniques. Our results call attention to the …

Identity And Resistance: Queer Puerto Rican Subjects, Pentecostalism, And The Shadow Of U.S. Imperialism, Jared Vázquez

Electronic Theses and Dissertations

James K.A. Smith argues that the first principle of Pentecostalism is that the same Holy Spirit described in the New Testament is !actively, dynamically, and miraculously present both in the ecclesial community and in creation” today. This ontological experience of the Holy Spirit transforms Pentecostalism into a hermeneutic thorough which Pentecostals interpret their social world. In his attempt to articulate a Pentecostal epistemology Smith leaves implied what this project seeks to make explicit: the emergence of subjectivity is mediated through the experiences of the body and is therefore affective and phenomenological in nature. I argue that pentecostal spiritual practices are …

Learning Approach For Fast Approximate Matrix Factorizations, Haiyan Yu

Electronic Theses and Dissertations

Efficiently computing an (approximate) orthonormal basis and low-rank approximation for the input data X plays a crucial role in data analysis. One of the most efficient algorithms for such tasks is the randomized algorithm, which proceeds by computing a projection XA with a random projection matrix A of much smaller size, and then computing the orthonormal basis as well as low-rank factorizations of the tall matrix XA. While a random matrix A is the de facto choice, in this work, we improve upon its performance by utilizing a learning approach to find an adaptive projection matrix A from a set …

Local-Global Results On Discrete Structures, Alexander Lewis Stevens

Electronic Theses and Dissertations

Local-global arguments, or those which glean global insights from local information, are central ideas in many areas of mathematics and computer science. For instance, in computer science a greedy algorithm makes locally optimal choices that are guaranteed to be consistent with a globally optimal solution. On the mathematical end, global information on Riemannian manifolds is often implied by (local) curvature lower bounds. Discrete notions of graph curvature have recently emerged, allowing ideas pioneered in Riemannian geometry to be extended to the discrete setting. Bakry- Émery curvature has been one such successful notion of curvature. In this thesis we use combinatorial …

Exploring The Relational Impact Of Breast Cancer On Younger Women Partnered With Women, Kaitlin V. Ross

Electronic Theses and Dissertations

Approximately 268,600 new cases of breast cancer in women are diagnosed each year in the United States. Due to improvements in cancer detection and treatment, survivorship is higher than in the past. More than ten percent of new diagnoses are in women 45 years or younger. There are approximately one million sexual minority individuals living with cancer in the US, yet this population is understudied in cancer care. For sexual minority women with breast cancer, sociocultural factors such as lack of affirmative care influences their disease experience. Further, sexual minority women and women partnered with women may be subject to …

Examining The Impact Of Discrimination, Shame, And Acculturation On Psychological Wellbeing Of East Asian International Students, Shao-Jung Stella Ko

Electronic Theses and Dissertations

This study examined the impact of discrimination, shame, and acculturation on the psychological wellbeing of East Asian international students in the U.S. Using the Minority Stress Theory as a framework, discrimination and shame were hypothesized to have a significant negative relationship with wellbeing while acculturation was hypothesized to moderate these relationships. A sample (N = 281) of East Asian international undergraduate students completed a web-based survey with measures of perceived discrimination, interpersonal shame, acculturation, and mental health outcomes. Regression analyses containing wellbeing (outcome), acculturation (moderator), discrimination (predictor), and shame (predictor) were performed to test the hypotheses using SPSS PROCESS macro …

Music Theory Pedagogy For The Violin: Cognitive Philosophy And Three Model Curricula, Morganne J. Mcintyre

Electronic Theses and Dissertations

Violin playing promotes a connection between mind and body that allows the performer to internalize, or embody, tactile features of the instrument, such as the distance between strings, the feeling of the fingertips on the fingerboard, the interval size between notes, and many other aspects. This thesis designs a pedagogy that employs the violin’s physical attributes to provide the beginning through advanced player with a deeper understanding of music theory. The thesis suggests pairing of physical learning and musical theory at each stage of a violinist’s musical education. Chapter 1 surveys embodied cognition and cognitive artifacts. Chapter 2 applies these …

Bicycles And Transit: Weather Or Not: A Study On The Effect Of Weather And Air Quality On Bicycle-Transit, Bicycle, Rail Transit Counts In Denver, Christiana M. Fairfield

Electronic Theses and Dissertations

The movement of people and goods within metropolitan areas is critically important to the operational efficiency and functionality of cities. This study explores the influence of local weather conditions and the air quality index on bicycle-transit user in Denver, Colorado. Based on bicycle-transit having two key components, bicycle and transit, the effect of local weather conditions and the air quality index is also explored with bicycle use and rail-transit usage. Key findings include: (1) the most significant variable across all three modes is temperature, (2) for bicycle-transit and bicycle use, there is a steady increase in ridership as temperatures increase …

Metaphors As Tools Of Translation In The Early Medieval English Pedagogical Tradition, Abigayil M. Wernsman

Electronic Theses and Dissertations

This dissertation examines three crucial texts written and translated from Latin into Old English between 800CE and 1010CE in medieval England by King Alfred, Bishop Æthelwold, and Abbot Ælfric. These texts are crafted to further political and educational power, reform, and change. It argues that the metaphors wielded within these pedagogical texts were essential to the cultivation of authority for kings and magisters, and the propagation of English as a written language. Utilizing the framework of conceptual metaphor with attention to the historicity surrounding each text, I examine the definitions of metaphor and of translation to argue that each text …

Puerto Ricans And Asthma: Looking Through The Lens Of Historical Trauma, Lisa Colón

Electronic Theses and Dissertations

This study utilized an explorative phenomenological qualitative design to begin understanding the many ways Puerto Ricans experience asthma. Further is sought to understand the asthma experience broadly and within the context of the hurricanes that devastated Puerto Rico in 2017 including the governments’ responses to that devastation. Another core goal of this study was the conceptual and empirical application of the theoretical framework of historical trauma to Puerto Ricans. I conducted 12 semi structured interviews with collaborators who expressed a range of asthma experiences. My collaborators represented a mixture of those who lived through the hurricanes in Puerto Rico and …

Where Virtual Well-Being Becomes Reality, Colleen M. Reilly

Electronic Theses and Dissertations

Strategies to mitigate the spread of COVID-19, specifically quarantine and social distancing protocols, have exposed a troubling paradox: mandated isolation meant to save lives has inadvertently contributed to a decline in America’s well-being. Prolonged isolation due to more remote work and decentralized workplaces has been associated with widespread loneliness and diminished physical and mental health, with effects compounded by limited face-to-face access to social support systems. While remote communication technologies (e.g., video chat) can connect individuals with colleagues and social networks, remote technologies might have limited effectiveness in business and social contexts. This study uses Roger’s Diffusion of Innovation Theory …

Emotion Dysregulation And Intimate Partner Aggression During Pregnancy: Leveraging Both Partners’ Experiences With Dyadic Data, Victoria M. Atzl

Electronic Theses and Dissertations

Intimate partner aggression (IPA) during pregnancy is a significant public health problem that has negative consequences for maternal and fetal health. This study examined emotion dysregulation as a potential predictor of IPA during pregnancy from a dyadic perspective. Participants were 113 couples expecting a baby and included 113 mothers (MOBs; Mage = 27.50 years, SDage = 5.53, rangeage = 19-40; 38.1% White, 24.8% Latinx, 15.9% African American, 14.2% biracial/multiracial, 3.5% Asian American/Pacific Islander, 2.7% Native American and .8% other) and 113 fathers (FOBs; Mage = 29.83 years, SDage = 7.61, rangeage = 18-55; 38.1% White, 22.1% African American, 20.4% Latinx, …

Trans And Genderqueer Military Service Member-Veterans: An Acculturation Phenomenology Of Civilian Reintegration, Joseph A. Galluzzo

Electronic Theses and Dissertations

As United States military policy continues to evolve and affirm the accession and retention of trans and genderqueer (TGQ) service members, more TGQ people will join and ultimately separate from military service. Reintegration is a term that represents the experience of beginning to separate from the military and transitioning into civilian life, and those who encounter it are referred to as military service member-veterans (MSMVs). Though empirical knowledge of reintegration for MSMVs overall continues to improve, cultural relevance has only recently been considered, and no research has investigated the reintegration experiences of TGQ MSMVs specifically. The primary purpose of this …

Geovisualization And Open-Source Web Mapping Of Big Origin-Destination Data, A Test Case, Joseph Hiebert

Electronic Theses and Dissertations

Migration plays a key role in determining the health and success of cities, counties, and countries. It also plays a key role in determining the health and wellbeing of the individuals and families that undergo a migration event. This has led many scholars to map and study global migration patterns to understand how and why people move. While migration data are powerful, the origin-destination (O-D), tabular format of the data can be hard to interpret. To make O-D data more powerful, geographers can lean on computer cartography and new geovisualization techniques to help decision makers make sense of large, complex …

Mis-Specification Of Functional Forms In Growth Mixture Modeling: A Monte Carlo Simulation, Richa Ghevarghese

Electronic Theses and Dissertations

Growth mixture modeling (GMM) is a methodological tool used to represent heterogeneity in longitudinal datasets through the identification of unobserved subgroups following qualitatively and quantitatively distinct trajectories in a population. These growth trajectories or functional forms are informed by the underlying developmental theory, are distinct to each subgroup, and form the core assumptions of the model. Therefore, the accuracy of the assumed functional forms of growth strongly influences substantive research and theories of growth. While there is evidence of mis-specified functional forms of growth in GMM literature, the weight of this violation has been largely overlooked. Current solutions to circumvent …

Measurements Of Atmospheric Radicals, Heather L. Runberg

Electronic Theses and Dissertations

Atmospheric particulate matter (PM) is a global health concern. PM_2.5 is formed primarily through combustion processes such as automobile use and industrial activity. Natural sources of PM_2.5 result from events like volcanos and wildfires. Upon inhalation, PM_2.5 is small enough to travel deep into the lungs where it can form reactive oxygen species (ROS), such as hydroxyl radical (OH), causing oxidative damage to pulmonary tissues. PM_2.5 has been linked to cardiopulmonary diseases such as asthma, chronic obstructive pulmonary disease (COPD), and high blood pressure.

PM_2.5 is small enough to remain aloft and travel many hundreds …

Monitoring Of State Transitions In Extreme Environment Application Materials Using Fiber Bragg Grating Sensors, Sabuj Khadka

Electronic Theses and Dissertations

By embedding both a single fiber Bragg grating (FBG) sensor and a thermocouple (TC) during the manufacturing for extreme environment applications of certain classes of materials such as metals and polymers, a novel in-situ approach was developed to precisely monitor their entire manufacturing processes. This novel monitoring technique was able to identify many characteristic points during the curing of room and high-temperature epoxies and the solidification processes of metal alloys composed of tin and bismuth which were selected in this research purely for verification purposes. Some of the characteristic points identified for the epoxies were: (i) the gel point, (ii) …

Esipt-Enabled Alkyne Migration Provides Rapid Access To Benzoxazinones, Andrés G. Muñoz

Electronic Theses and Dissertations

Benozoxazinones have long been of interest to agrochemical scientists and medicinal chemists because of their widespread biological activity. These scaffolds are also of interest to synthetic chemists, who recognize the utility of benzoxazinones for accessing functionalized heterocycles. The use of efavirenz, a benzoxazinone-based reverse transcriptase inhibitor used in the treatment of HIV-1, has brought increased attention to this privileged pharmacophore. While there exist numerous strategies for synthesizing benzoxazinones, methods that do not require the use of acutely toxic and environmentally hazardous reagents are lacking. Consequently, there is a need to develop new methods for constructing this valuable scaffold. Herein, we …

The Intersection Of Traumatic Brain Injury And Homelessness, Stephanie A. Chassman

Electronic Theses and Dissertations

The rates of TBI are significantly higher among individuals experiencing homelessness compared to the general population. Up to half of individuals experiencing homelessness may have a TBI. Accurate prevalence rates of TBI among individuals experiencing homelessness are difficult to obtain due to different methods of sampling participants and differing definitions of TBI; therefore, estimates may be underrepresented. Despite past research that has examined the relationship between TBI and homelessness, there are specific gaps in knowledge such as correlates and risk factors of TBI among individuals experiencing homelessness. This three-manuscript dissertation attempts to address these gaps in knowledge.

The first manuscript …

Developing, Refining, And Testing The Intersectional Model Of Service Use: A Transgender And Nonbinary-Specific Model Of Healthcare Access, Jarrod Call

Electronic Theses and Dissertations

Transgender and nonbinary (TNB) people are more likely to experience negative health outcomes than cisgender (i.e., not TNB) people, but less likely to access healthcare services due to the systemic forces of transphobia and cisgenderism. Despite this, there are few theoretical models of healthcare access specifically designed for TNB people. This three-paper dissertation addresses this gap by developing, refining, and testing the Intersectional Model of Service Use (IMSU), a population-specific framework for researching TNB healthcare access. Manuscript one describes how the initial IMSU was developed from an integrative review of currently available TNB healthcare access literature. This initial IMSU was …

Extracellular Vesicles And Lipid Flippase Regulators In C. Elegans, Lauren Pitts

Electronic Theses and Dissertations

Extracellular vesicles (EVs) are membrane derived organelles released by all cell types and carry a vast array of cargos that can influence communication, development, and disease. One type of EV, known as microvesicles, form by budding directly from the plasma membrane in a process known as ectocytosis, however the mechanisms that govern this process are poorly understood. In C. elegans, the P4-ATPase, TAT-5, along with its activator, PAD-1, inhibit EV release from the plasma membrane by inhibiting phosphatidylethanolamine (PE) exposure on the outer leaflet of the plasma membrane. We identified 3 key domains of PAD-1 that are required to inhibit …

Economic Theology And The Death Of God In The Context Of The Crisis Of Neoliberalism, Jared A. Lacy

Electronic Theses and Dissertations

In light of the ongoing political and economic crises in the twenty-first century, this study aims to apply the discourse of political theology, alongside Nietzsche’s concept of the death of God to an understanding of neoliberalism and the problems it faces on a global level. However, because of the centrality of sovereignty in political theological discourse and the view of neoliberalism as diffusing sovereignty in favor of an ordered system, I attempt to further develop an offshoot discourse of political theology referred to as economic theology. This discourse allows a theological signature of power to be traced through the history …

Critical Experiences Of Being Humbled In Psychotherapy Training: An Interpretative Phenomenological Analysis, Mackenzie White Jessen

Electronic Theses and Dissertations

Therapists’ cultural humility has shown promise for being a “trait like” quality that improves psychotherapy treatment for marginalized populations (Hook et al., 2016, Owen et al., 2016). However, researchers have emphasized that it is important to establish whether cultural humility can be fostered or developed through training (Davis et al., 2016). The purpose of this study was to understand the phenomenon of trainees being humbled in session during graduate school training and its potential relationship to trainee development. This is the first study to specifically examine the experience of being humbled by clients in session or that explores the potential …

Structural And Hemodynamic Analysis Of Transcatheter Aortic Valves, Dong Qiu

Electronic Theses and Dissertations

The transcatheter aortic valve replacement (TAVR) procedure has become a well-established procedure for high, intermediate-risk, and low-risk patients. However, there is limited clinical data on the TAV's long-term durability, unlike SAV devices. Computational simulations can be an alternative way to evaluate the TAV devices. This dissertation aims to conduct structural and hemodynamic analyses on the TAV devices under different conditions using computational simulation approaches.

Initially, the impact of the bicuspid aortic valve on the TAV devices was evaluated. The result indicated that the CoreValve-like supra-annular self-expandable device was likely to have increased stress and strain on the leaflet when it …