Digital Commons Network^™

Designing Without Boundaries., Mickey Glover

Electronic Theses and Dissertations

This thesis was written as a supporting paper for a graphic design exhibit for a Master of Fine Arts Degree. The focus of my design is the creation of successful pieces of expressive graphic design that defy many traditional or formal rules of design.

This thesis begins with a brief explanation of my methods and what I feel makes for good expressive design. These include a heavy reliance upon intuition, the necessity of traditional design education, historical and contemporary influences. I then characterize my motivations and methods of creating graphic design. Followed by the relation of my work to historical …

Flavone: The Molecular And Mechanistic Study Of How A Simple Flavonoid Protects Dna From Oxidative Damage., Jennifer Dawn Dean

Electronic Theses and Dissertations

Dietary flavonoids are ubiquitous and are marketed as supplements. Characterized as antioxidants, they offer protection against a number of degenerative diseases. Flavonoid mechanics involve free radical scavenging, metal chelation, and substrate association. The skeletal structure of flavonoids is a fused ring system modified by hydroxyl, sugar, and carbohydrate additions. Flavone is a structurally simple flavonoid. Quercetin and its glycosidic analog rutin are complex structures. Using a DNA oxidation/cleavage assay, flavone reduces DNA nicking by 91%. Depending on the solvent system used, quercetin can either increase or decrease DNA oxidation. Rutin exhibits neither pro- nor antioxidant activity. The molecular interactions responsible …

The Osteogenic Effects Of 12 Weeks Of Oral Supplementation Of Androstenedione In Middle-Aged Men., Troy Matthew Wills

Electronic Theses and Dissertations

Recent evidence suggests that declining bone mineral density (BMD) in males is related to declining circulating estrogens. The majority of endogenous plasma estrogens in males result from peripheral aromatization of plasma androgens. Thus, it was hypothesized that dietary supplementation with an aromatizable androgen (androstenedione) may stimulate increases in BMD.

BMD (measured by dual energy x-ray absorptiometry) and biochemical markers of bone turnover (1, 25 OH2 Vitamin D, calcitonin, deoxypyrodinoline, and parathyroid hormone) were assessed before and after 12 weeks of dietary androstenedione supplementation (200 mg/d). Twenty-four volunteers were randomized into either an androstenedione supplementation or placebo groups. Study volunteers also …

Jeffersonianism And 19th Century American Maritime Defense Policy., Christopher Taylor Ziegler

Electronic Theses and Dissertations

This paper analyzes the fundamental maritime defense mentality that permeated America throughout the early part of the Republic. For fear of economic debt and foreign wars, Thomas Jefferson and his Republican party, opposed the construction of a formidable blue water naval force. Instead, they argued for a small naval force capable of engaging the Barbary pirates and other small similar forces. For protection of the nation and commerce, they wanted a strictly defensive strategy developed around coastal gunboats and harbor fortifications. This research will analyze the naval aspect of this defense mentality from its creation in 1794, through the War …

A Comparison Of Bioaccumulation And Digestive Enzyme Solubilization Of Copper In Two Species Of Sea Cucumbers With Different Feeding Habits., John W. Bundridge

Electronic Theses and Dissertations

The mode of feeding exhibited by different organisms may influence the form or quantity of copper that is bioaccumulated. This hypothesis has been tested by exposing 2 species of sea cucumbers, Pentacta anceps and Stichopus chloronotus, which possess different feeding modes, to varying concentrations of copper.

The digestive tract and body wall were dissected and analyzed for copper concentration using atomic absorption spectroscopy. A trend was present, exhibiting a small dose dependent curve. The results did not show a significant difference between species or treatments. This study indicates that feeding mode may influence the amount of copper accumulated but …

Perceived Effectiveness Of Conflict Management Strategies In Dating Relationships., Jaime Ann Counts

Electronic Theses and Dissertations

The purpose of the present study was to determine how college participants view the success of different conflict management strategies: chance, manipulation, compliance, and confrontation. The success of the conflict management strategies was evaluated by how participants rated female satisfaction, male satisfaction, likelihood of marriage and success of marriage. A MANOVA, and a Roy Bargman step-down procedure were conducted on all dependent variables. A Tukey HSD post hoc test was ran to reveal which conflict management strategies differed from one another. Results indicated that participants thought women were less satisfied than men. For male satisfaction and likelihood of marriage, post …

Sex And Pottery: Erotic Images On Athenian Cups, 600-300 B.C., Michael Lee Banner

Electronic Theses and Dissertations

Many pages have been written concerning erotic images on Greek vases but few studies have focused on the frequency of erotic images. This is an important concept in determining the significance of the erotic images. Various Athenian cups from the online holdings of the Beazley Archive were investigated, using simple tabulations and Chi-square analysis, for erotic images. Out of 7901 cups only 130 had erotic images. As cups with erotic images represented only a small portion of the sample it was likely that they only appealed to the tastes of a small sub-set of the Athenian population. The context of …

Police Officers' Perception Of The Validity Of The General Theory Of Crime., William Jaison Giesler

Electronic Theses and Dissertations

This study measured police officers perception of the validity of General Theory of Crime. Using a sample of 117 officers and an adapted version of the Grasmick et al. (1993) self-control scale, this study measures the level of agreement officers exhibit that low self-control traits are present in property and violent offenders. Measurement is also performed to determine variation in officers agreement based on the personal characteristics gender, age, education, experience, and rank.

Findings indicate officers show agreement with self-control items across the six dimensions of self control traits, as well as significant variation in agreement with the property offender …

Patience : A Play In Two Acts., Mary Rotella 1958-

Electronic Theses and Dissertations

When Howard Manning wakes from a fainting spell to find himself hospitalized with a serious but correctable weakness in his heart, his refusal of treatment intimates a death wish that provokes consternation among the skilled medical professionals who are poised to save his life. The first act explores the character and implications of his resistance in relation to the expectations of his surgeon Dr. Vincent Abel, nurse Zo Clement, psychiatry resident Trudy Zeffirelli, and neighboring patient Clarence Weatherby. It culminates with Manning's precipitous and injurious departure against medical advice. The second act reveals Manning returned to his hospital bed, withdrawn …

Synthesis Of Peptides With Hydroxamic Acid Side Chain Appendages., Yingchuan Susan Sun 1975-

Electronic Theses and Dissertations

Chapter 1 detailed the synthesis method of hydroxamate peptides derivatives of pentapeptide Ac-PHSXX\'-N-NH2 by solid phase hydroxamate peptide synthesis method. The glutamic acid/aspartic acid side chain was modified to hydroxamic acid by on resin N-C coupling. The hydroxamate benzyl protecting group was removed during HF cleavage. In Chapter 2 a novel multiple hydroxamic acid peptide siderophore was prepared and the metal binding activity of these peptides was studied by ESI-MS and MS/MS. Siderophore peptide Ac-Gly1-Glu2(NHOH)-D-Pro3-Gly4-Glu5(NHOH)-D-Pro6-NH2 was found to have significant preference to Fe(III) over Zn(II) and Ni(II), while the natural peptide analogue Ac-Gly1-Glu2-D-Pro 3-Gly4-Glu5-D-Pro6-NH2 did not show any obvious preference …

A Markov Model Of Secondary Prevention Of Osteoportic Hip Fractures., Stephanie Tapp

Electronic Theses and Dissertations

Low-trauma fractures of older women are a major public health burden. Fractures of the hip and spine are some of the primary causes of chronic pain, functional impairment, and disability among the elderly [1]. The underlying cause of these fractures is osteoporosis. Although the disease is common, only a small proportion (15%-20%) of women at risk currently receive preventative treatment [2]. We have focused our attention to white postmenopausal women who have sustained a fracture of the distal radius. We developed a Markov model using probabilities obtained from recent literature in order to evaluated the effects of three hypothetical interventions …

Functional Proteomic Analysis Of The Myocardial Pkcepsilon Subproteome Pkcepsilon-Akt-Enos Signaling Modules And During., Jun Zhang

Electronic Theses and Dissertations

Ischemic heart disease is the leading cause of mortality and morbidity in Western societies. Thus, understanding the molecular mechanisms to reduce myocardial ischemia and limit infarction size are of great importance. Ample evidence has shown that protein kinase C epsilon (PKCepsilon) play an essential role in the genesis of cardioprotection. In particular, our laboratory has shown that activation of PKCepsilon in the heart is sufficient to significantly reduce myocardial infarction due to coronary artery occlusion. However, the molecular mechanism responsible for PKCepsilon-induced cardioprotection remain unclear. Recently, functional proteomic analysis have demonstrated that PKCepsilon forms signaling complexes with various of proteins, …

Oxygen Toxicity And Mitochondrial Metabolism., Jian Li 1974-

Electronic Theses and Dissertations

Oxygen is critical to aerobic metabolism, but hyperoxia is cytostatic and cytocidal. The precise mechanisms involved in hyperoxic cell injury remain incompletely understood although there is substantial support for the possibility that hyperoxia increases the 'leak' of electrons from the mitochondrial electron transport chain and the resulting increased generation of reactive oxygen species (ROS) might explain the toxic effects of high oxygen. To evaluate the possible role of mitochondria in oxygen toxicity, we used cloned HeLa cells having no functional mitochondria (?° cells) as a model. In contrast to wild-type HeLa cells, ?° cells survive and grow in 80% O2 …

An Exploration Of The Influence Of Demographic Factors On Individual And Aggregate Student Achievement Measurements In The Kentucky Accountability System., Beverly Lee Derrington Moore 1938-

Electronic Theses and Dissertations

This study investigates the progress of standards-based accountability in eliminating the effects of student background and school composition factors on student achievement and school performance in a large, urban district in Kentucky. The factors included gender, socioeconomic status (SES), ethnicity, mobility, family structure, giftedness, and disability. The school composition variables were the percentages of those factors in the school populations. Each grade and level--elementary, middle, and high school--was analyzed by multiple regression. At the student level, SES, giftedness, and disability predicted 15 to 36% of the variance in scores. SES, family structure, and mobility rate accounted for 56 to 91% …

State Political Culture And The Affordability Of Higher Education : A Multivariate Analysis Of The Impact Of State Higher Education Systems On The Cost Of Attending College., Angela Perkins Girdley 1964-

Electronic Theses and Dissertations

The purpose of this study was to understand variance in state system performance in affordability using variables describing the state political environment and the higher education governance structure. Understanding how the political culture of states affects higher education illuminates agendas, priorities, and motivations of key decision-makers in higher education. The dependent variable was affordability of higher education measured by the National Council on Public Policy in Higher Education "Measuring Up" (2000) grade. Independent variables were the impact of special interest groups, the state higher education governance structure, legislative professionalization, and the institutional strength of the governor. Pearson product-moment correlations and …

Regulation Of Na,K-Atpase Activity By Tyrosine Phosphorylation In Lens Cells., Larry Darko Bozulic 1974-

Electronic Theses and Dissertations

Na,K-ATPase is essential for the regulation of cytoplasmic Na+ and K+ levels in lens cells. Insufficient Na,K-ATPase activity is associated with cataract formation. Based on earlier studies in which Src-tyrosine kinase inhibitors were found to suppress Na,K-ATPase activity changes that occur in response to either thrombin, endothelin, or dopamine, I hypothesize that regulation of Na,K-ATPase activity might occur through phosphorylation of the Na,K-ATPase a1 (catalytic) subunit by Src-family tyrosine kinases. Here, I tested the influence of Src-kinase family members on tyrosine phosphorylation and Na,K-ATPase activity in membrane material isolated from porcine lens epithelium. Western blot studies indicated the expression of …

Factors That Predict Student Performance In Dual Credit Courses In Kentucky Community And Technical Colleges., Nicholas L. Brake

Electronic Theses and Dissertations

This research addresses the problem of productivity in the P-16 system of education, emphasizing the repetition of the senior year of high school with the first year of postsecondary education. This study analyzes this integration through dual credit courses in the context of both P-12 and higher education reform in Kentucky. An analysis of these factors is critical in light of the deregulation of dual credit in Kentucky since 2000 and the increased enrollment of high school students in college courses both nationally and in Kentucky. Dual credit courses in Kentucky community and technical colleges are evaluated based on the …

James Wilson : Progressive Constitutionalist., Bradley Jay Caffee 1972-

Electronic Theses and Dissertations

This essay is a biography and ideological interpretation of James Wilson. Wilson was an important member of the Revolutionary generation whom historians and political theorists too often overlook. Moving from the rise of historical interest in Wilson and reasons why Wilson deserves study, this essay tells the story of Wilson's ideological development from the opposition Whig struggles of the 1760s until his law lectures in 1790 and 1791. Originally willing to accept Lockean ideas of contractualism in the British constitution he, like many Americans, rejected such contractualism during the Revolution in favor of an un-transferrable popular sovereignty that could only …

The Problem Of Religious Diversity : A Study And Critique Of The Philosophy Of John Hick., John K. Dryden 1976-

Electronic Theses and Dissertations

This thesis is a study and critique of John Hick's pluralistic hypothesis as presented in his book "An Interpretation of Religion." I primarily focus on two issues: Hick's epistemology of religious beliefs and the pluralistic hypothesis itself. These are two separate issues, but for Hick they prove to be inextricably linked. Hick uses his epistemological stance to argue that there is an epistemological problem of religious diversity. After he argues that there is a problem, he presents his solution, i.e. the pluralistic hypothesis. After explaining these issues, my critique focuses upon the connection between the two. I first critique Hick's …

The Creation Of A Worldview., Jamie Bryan Price

Electronic Theses and Dissertations

This is an analysis of how fin-de-siècle Vienna and its mayor, Karl Lueger, influenced the development of Adolf Hitler’s worldview.

The works of many authors were consulted in conjunction with newspapers and memoirs of the period in order to gain a better understanding of what the environment of the Austrian capital was like in the fin-de-siècle period.

Several of Vienna’s political, social, and artistic facets are analyzed in an attempt to prove that the general atmosphere of the city influenced Adolf Hitler greatly during his formative years. It is concluded that while Adolf Hitler’s Weltanschauung did not completely crystallize until …

Beauty As Currency, Joseph Abide

Electronic Theses and Dissertations

This body of work addresses the concept of physical beauty and the attendant value that we as a society place upon it. Beauty shares characteristics with other prized possessions in life. It may be traded for monetary gain, as is the case with professional models. The exchange is not always so obvious. What constitutes beauty is open to many interpretations as to why it is deemed desirable. I have observed physical characteristics which are valued as attractive, change, from one social group to another and within that same society evolve with the passage of time.

Physical beauty differs from other …

Developing Efficient Technique In Beginning Piano Students, Fen-Fang Chen

Electronic Theses and Dissertations

No abstract provided.

Analyzing Rhetoric : A Frame Analysis Of The Pro-Life Movement In The United States., Juanita Raley Shever 1949-

Electronic Theses and Dissertations

The purpose of this study is to consider the significance of rhetoric used by pro-life social movement organizations to frame the experience of abortion and to label those women who have participated in that experience. The study explores how frames are devised and how these frames are applied so that reality is organized in such a manner as to appear aligned with the religious, moral, and/or philosophical position of the pro-life movement. The study uses pro-life web pages to obtain data; then, analyzes the data for emerging themes and content. The general tasks of framing such as agenda setting are …

Studies Of The Effects Of Pancreatic Beta Cell Antioxidant Transgenes On Experimental Models Of Diabetes., Hainan Chen

Electronic Theses and Dissertations

Pancreatic beta cells are extremely vulnerable to the destruction of Reactive Oxygen Species (ROS). In both type 1 and type 2 diabetes ROS are involved in the loss of U+000DF-cells. We hypothesized that the deficiency in ROS detoxifying system of U+000DF-cells resulted in U+000DF-cell vulnerability and enhanced ROS protection would protect from diabetes. To test this hypothesis, transgenic mice with overexpression of U+000DF-cell antioxidant protein metallothionein (MT), manganese superoxide dismutase (MnSOD) and catalase were produced on an FVB background. Initial studies demonstrated that these transgenes did not affect U+000DF-cell normal function and morphology. But those transgenes significantly protected pancreatic islets …

A Comparative Analysis Of Mentoring As A Socializing Strategy Among Law Faculty., Ray Kennard Haynes 1963-

Electronic Theses and Dissertations

This dissertation used a comparative analysis approach to determine mentoring's ability to socialize law faculty. Specifically, it sought to examine the efficacy of formal and informal mentoring in socializing law faculty to their respective institutions. A Mentoring Questionnaire was developed to determine the occurrence of mentoring, the distinctions between the various forms of mentoring, and law faculty perceptions of the effectiveness of the various forms of mentoring received. The Organizational Socialization Questionnaire measured socialization along six dimensions of People, Performance Proficiency, Politics, Language, History and Organizational Goals and Values and was used to determine socialization differences among mentored and non-mentored …

Process Of Performance : An Acting Thesis., Jennifer Ann Hunt 1970-

Electronic Theses and Dissertations

In fulfillment of the thesis project requirement for the Master of Fine Arts Degree at the University of Louisville, I portrayed the multiple roles of Clytemnestra, Electra and Athena in Dr. Steve Schultz's translation of Aeschylus' "Oresteia" in February 1998. Additionally I acted in at least one play each semester utilizing the skills and techniques that I learned in the program's classwork. This document includes a discussion of each class, the methodology studied and how I was able to apply each class to that semester's acting project. It also contains personal observations of my own strengths and weaknesses as an …

Marshall Keeble And The Implementation Of A Grand Strategy., Darrell L. Broking

Electronic Theses and Dissertations

This study examines the development of Marshall Keeble’s work during the early and middle parts of the twentieth century in the Church of Christ. The purpose of this study is to examine the direction taken by Keeble in his work and determine whether he was a submissive Tom used by whites to accomplish their goals among blacks, or to determine if he was pursuing his own grand strategy to defuse racial tension in the Church of Christ. Conclusions of this research denote that Marshall Keeble was following a grand strategy, or a decisive course of action designed to erase the …

Healthcare Strategic Management: The Impact Of State And Federal Funding Levels On The Implementation Of Strategic Plans At Tennessee Hospitals., Randy Lee Byington

Electronic Theses and Dissertations

The purpose of this study was to determine hospital executive management’s perceptions of how turbulence in the politico-legal sector of the macroenvironment impacted the strategic management systems of Tennessee hospitals. In particular, how did Federal and State funding restrictions (Medicare and TennCare) impact the strategic planning and implementation process of their hospitals? The study was also designed to gain insight regarding specific changes to strategic management systems that may have resulted from these funding restrictions.

The research was conducted during April and May of 2003. Data were gathered by surveying the Chief Executive Officers (CEOs) of acute care hospitals in …

Leadership Practices Of Veterans Health Administration Nurse Executives., Virginia Holt Bieber

Electronic Theses and Dissertations

Transformational leadership has been linked to improved organizational performance and has been recognized as a possible solution to the challenges in Health Care. The role of Nurse Executives (NE) has become an influential leadership position in Health Care Organizations (HCO) and a factor in improving HCO. The purpose of this research was to explore self-reported leadership practices of Veterans Health Administration (VHA) Medical Center NEs, examine leadership strengths of the NEs, and report professional development needs of the NEs.

The study population consisted of NEs employed in the Veterans Affairs Medical Centers (VAMC’s) throughout the United States. The Leadership Practices …

A Historical Review And Financial Analysis Of Higher Education Funding In Tennessee., Claire Sauls Stinson

Electronic Theses and Dissertations

This was a study of the development of an objective funding method for public higher education institutions in Tennessee. The review covers the history of higher education funding from the early 1800s through the beginning of the twenty-first century with emphasis on the early 1960s through the year 2000. The study describes and analyzes the efforts made in Tennessee to provide adequate and equitable funding to public higher education institutions.

Minutes of meetings of the Tennessee Higher Education Commission, reports on studies commissioned by state officials, accountability reports prepared by the Tennessee Higher Education Commission, the Tennessee Board of Regents …