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Fluorinated Organic Molecules For Medicinal Applications, Munia Sowaileh Jan 2018

Fluorinated Organic Molecules For Medicinal Applications, Munia Sowaileh

Electronic Theses and Dissertations

The significant applications of fluorinated molecules in the pharmaceutical, agrochemical, and material sciences make them attractive synthetic targets. Difluoromethylation methods are of exceptional value and a limited number of techniques are available to perform that transformation. The primary method for introducing CF2 groups is through the use of difluoroenolates. Difluoroenolates can be generated from α-keto pentafluoro gem -diols under mild conditions. The process involves the cleavage of carbon-carbon bond and the release of trifluoroacetate. The release of trifluoroacetate is a versatile method to generate fluorinated molecules. We explored the utility of this method in generating various fluorinated moieties including α,α-difluoroketones, …


Novel Application Of Twin Screw Extruder On Production Of Diverse Formulations, Xingyou Ye Jan 2018

Novel Application Of Twin Screw Extruder On Production Of Diverse Formulations, Xingyou Ye

Electronic Theses and Dissertations

Twin-screw extruder has attracted considerable attention in the pharmaceutical industry as an alternative processing instrument due to its advantages compared to other conventional equipment, such as economical processing, small footprint, reduced in-process times, solvent-free and continuous processing. These superiorities have led to the application of twin-screw extruder to produce numerous dosage forms, including pellets, tablets and films. Many other formulations production can also be beneficial from the introduction of twin-screw extruder to the process. Nanocrystal formulations are promising drug delivery systems owing to their ability to enhance the bioavailability and maintain the stability of poorly water-soluble drugs. However, conventional methods …


Synthesis And Evaluation Of Dual-Acting Ligands For Mu Opioid And Neuropeptide Ff Receptors, Kelsey Gabrielle Mcpherson Jan 2018

Synthesis And Evaluation Of Dual-Acting Ligands For Mu Opioid And Neuropeptide Ff Receptors, Kelsey Gabrielle Mcpherson

Electronic Theses and Dissertations

Pain, although subjective, is an unpleasant sensation caused by a noxious stimulus, that effects millions of people every year. Currently, the most frequently prescribed class of analgesics for moderate to severe acute and sometime chronic pain are opioid analgesics, most commonly ?-opioid receptor (MOP) agonists, such as oxycodone, morphine, and fentanyl. Although these drugs provide significant pain relief, they are also associated with unwelcome side effects such as constipation, addiction, physical dependence, respiratory depression, and physiological tolerance that leads to hyperalgesia. Receptor desensitization due to excessive receptor activation by an agonist is but one source of physiological tolerance; it can …


The Effect Of Environmental Perturbations On The Plant Phyllosphere Microbiome, Bram W. Stone Jan 2018

The Effect Of Environmental Perturbations On The Plant Phyllosphere Microbiome, Bram W. Stone

Electronic Theses and Dissertations

Applying ecological concepts to microbial communities has proved to be challenging, often revolving around the relative importance of stochastic and deterministic processes applied heterogeneously across the habitat in time or space. The phyllosphere is the aboveground surface of plants on which microbial communities, composed primarily of Bacteria, but also including Archaea and microbial eukaryotes, exist and is characterized by stochastic immigration balanced with strong selective forces. Variation in bacterial community composition was characterized across space and time, with special attention given to the exposure of phyllosphere communities to rain as a plausible mechanism of ecological disturbance. Bacterial communities were characterized …


Counter Clockwise Culture Shock, Matthew Mercer Jan 2018

Counter Clockwise Culture Shock, Matthew Mercer

Electronic Theses and Dissertations

Counter Clockwise Culture Shock is a memoir focused the narrator's return to his hometown, a place he barely escaped: drug addiction, incarceration, bad relationships, alienation, an Oedipal mother, and suicidal threats. It is reflection on both culture and self, after I gained an outside perspective from Japan. The narrator is forced to relive nihilism and monotony, and face the troubles of his younger years. It describes the difficult journey of today's youth, in an evermore technologically dynamic world - with few role models able to plot a course through. This is a meditation on past actions that ended in survival. …


Exploring Fpga Implementation For Binarized Neural Network Inference, Li Yang Jan 2018

Exploring Fpga Implementation For Binarized Neural Network Inference, Li Yang

Electronic Theses and Dissertations

Deep convolutional neural network has taken an important role in machine learning algorithm. It is widely used in different areas such as computer vision, robotics, and biology. However, the models of deep neural networks become larger and more computation complexity which is a big obstacle for such huge model to implement on embedded systems. Recent works have shown the binarized neural networks (BNN), utilizing binarized (i.e. +1 and -1) convolution kernel and binarized activation function, can significantly reduce the parameter size and computation cost, which makes it hardware-friendly for Field-Programmable Gate Arrays (FPGAs) implementation with efficient energy cost. This thesis …


Behavioral And Disease Ecology Of Gopher Tortoises (Gopherus Polyphemus) Post Exclusion And Relocation With A Novel Approach To Homing Determination, Johnathan Napier Jan 2018

Behavioral And Disease Ecology Of Gopher Tortoises (Gopherus Polyphemus) Post Exclusion And Relocation With A Novel Approach To Homing Determination, Johnathan Napier

Electronic Theses and Dissertations

In the wake of human expansion, relocations and the loss of habitat can be stressful to an organism, plausibly leading to population declines. The gopher tortoise (Gopherus polyphemus) is a keystone species that constructs burrows it shares with 362 commensal species. Frequent exclusions and relocations and long generation times have contributed to G. polyphemus being State-designated as Threatened in Florida. Prior studies have indicated that G. polyphemus may possess homing behavior and thus be able to counteract stressors due to relocation and exclusion. I radiotracked a cohort of G. polyphemus for 11 months following excavation, relocation, and exclusion due to …


Numerical Study Of Interfacial Flow Using Algebraic Coupled Level Set-Volume Of Fluid (A-Clsvof) Method, Majid Haghshenas Jan 2018

Numerical Study Of Interfacial Flow Using Algebraic Coupled Level Set-Volume Of Fluid (A-Clsvof) Method, Majid Haghshenas

Electronic Theses and Dissertations

Solving interfacial flows numerically has been a challenge due to the lack of sharpness and the presence of spurious currents at the interface. Two methods, Algebraic Coupled Level Set-Volume of Fluid (A-CLSVOF) method and Ghost Fluid Method (GFM) have been developed in the finite volume framework and employed in several interfacial flows such as Rayleigh-Taylor instability, rising bubble, impinging droplet and cross-flow oil plume. In the static droplet simulation, A-CLSVOF substantially reduces the spurious currents. The capillary wave relaxation shows that this method delivers results comparable to those of more rigorous methods such as Front Tracking methods for fine grids. …


Hibridación Y Subversión De Arquetipos Femeninos Latinoamericanos En Alfonsina Storni, Gabriela Mistral Y Silvina Ocampo, Aned Ladino Jan 2018

Hibridación Y Subversión De Arquetipos Femeninos Latinoamericanos En Alfonsina Storni, Gabriela Mistral Y Silvina Ocampo, Aned Ladino

Electronic Theses and Dissertations

Social, political, and economic transformations contributed to redefine gender roles at the beginning of the twentieth century. In Latin America, Alfonsina Storni (1889-1938), Gabriela Mistral (1892-1957) and Silvina Ocampo (1906-1993) produced a hybrid narrative that challenged heteronormative conventions. In dialogue with a global realignment, they advocated for the rights of mestiza, indigenous, and working class subjects. This thesis proposes that the authors participated in a worldwide transformation that established women as historical agents. The research incorporates poems, essays, and short stories to map the emergence of independent, clever, and ambiguous models of femininity. They deployed traditional archetypes, such as the …


Raça, Jinshu, Race: Whiteness, Japanese-Ness, And Resistance In Sūkyō Mahikari In The Brazilian Amazon, Moana Luri De Almeida Jan 2018

Raça, Jinshu, Race: Whiteness, Japanese-Ness, And Resistance In Sūkyō Mahikari In The Brazilian Amazon, Moana Luri De Almeida

Electronic Theses and Dissertations

This dissertation presented an analysis of how leaders and adherents of a Japanese religion called Sūkyō Mahikari understand and interpret jinshu (race) and hito(person) in a particular way, and how this ideology is practiced in the city of Belém, in the Brazilian Amazon. The teachings of Sūkyō Mahikari classify humanity into five races (yellow, white, red, blue/green, black/purple) and five religions (Christianity, Islam, Buddhism, Confucianism, Taoism). In this classification, the original humans - hito, the kingly race ōbito, and the God-given supra-religion sūkyō - deteriorated into ningen (people), the other races, and shūkyō (religions) along an …


Dynamic Hotspot Identification For Limited Access Facilities Using Temporal Traffic Data, Samer Al Amili Jan 2018

Dynamic Hotspot Identification For Limited Access Facilities Using Temporal Traffic Data, Samer Al Amili

Electronic Theses and Dissertations

Crash frequency analysis is the most critical tool to investigate traffic safety problems. Therefore, an accurate crash analysis must be conducted. Since traffic continually fluctuates over time and this effects potential of crash occurrence, shorter time periods and less aggregated traffic factors (shorter intervals than AADT) need to be used. In this dissertation, several methodologies have been conducted to elevate the accuracy of crash prediction. The performance of using less aggregated traffic data in modeling crash frequency was explored for weekdays and weekends. Four-time periods for weekdays and two time periods for weekends, with four intervals (5, 15, 30, and …


Style Speaks: Clothing Judgments, Gender Stereotypes, And Expectancy Violations Of Professional Women, Jamie Lower Jan 2018

Style Speaks: Clothing Judgments, Gender Stereotypes, And Expectancy Violations Of Professional Women, Jamie Lower

Electronic Theses and Dissertations

Clothing is a powerful nonverbal communicative tool and form of self-expression that provides others with clues about our personality, mood, education, culture, financial status, and social ranking, amongst numerous other impression cues. Research shows that physical appearance plays a prominent role in the formation of initial judgments and is significant in shaping a person's overall impression on others (Richmond, McCroskey, & Payne, 1991). The present study sought to quantitatively explore the effect that different styles of dress have on initial judgments formed about women in workplace settings. Using expectancy violation theory, the study investigates workplace gender bias and whether or …


Narrative Transportation And Virtual Reality: Exploring The Immersive Qualities Of Social Justice In The Digital World, Sara Raffel Jan 2018

Narrative Transportation And Virtual Reality: Exploring The Immersive Qualities Of Social Justice In The Digital World, Sara Raffel

Electronic Theses and Dissertations

This dissertation explores the potential applications for virtual reality (VR) stories in support of social justice causes, examining whether digital games historically been successfully leveraged for social justice purposes, and determining which components of VR technology can most encourage narrative transportation of participants in VR stories. The first chapter examines theories of simulation, virtual reality, narrative, and interactivity, as well as concepts of immersion from various disciplines and settles on narrative transportation, a theory from cognitive psychology, as the most useful in measuring the effect of VR stories on participants. The second chapter examines ethnographic practices, activist games, and modes …


Business Closure In The North American Theme Park Industry: An Analysis Of Causes, Kelly Kaak Jan 2018

Business Closure In The North American Theme Park Industry: An Analysis Of Causes, Kelly Kaak

Electronic Theses and Dissertations

Prior to this study, no analysis had focused on the 31% failure rate recorded among theme parks opened in North American between the years 1955 and 2009. This study's purpose was to identify the causes of closures among the 23 failed theme parks and inform the industry of what can be learned from these business failures. Business failure analysis typically stresses the impact of financial ratios and the accuracy of certain negative numbers to predict impending failure, but such studies avoid examining the underlying causes that lead to poor financial performance in the first place. To focus on this question, …


Aging Well: How Subjective Age, Playfulness, And Depression Influence Quality Of Life Among Older Adults, Yvette Saliba El Habre Jan 2018

Aging Well: How Subjective Age, Playfulness, And Depression Influence Quality Of Life Among Older Adults, Yvette Saliba El Habre

Electronic Theses and Dissertations

Given the growing population of aging adults, there is a need for research examining factors that enhance quality of life for older adults (QoL; Colby & Ortman, 2014). Changes in health, relationships, support systems, and social identity are inevitable throughout the lifespan. Therefore, research focused on lessening the negative effects of changes due to aging while also improving QoL is warranted. As such, the aim of the current research study was to examine the extent to which subjective age (SA; how old or young an individual feels), playfulness (PF; "the ability to frame or reframe everyday situations to experience them …


Hole Selective Tunneling Oxide Applications With Insight Into Sophisticated Characterization Techniques, Nizamettin Kortan Ogutman Jan 2018

Hole Selective Tunneling Oxide Applications With Insight Into Sophisticated Characterization Techniques, Nizamettin Kortan Ogutman

Electronic Theses and Dissertations

Tunneling metal oxide layers combined with industrially applicable novel cleaning methods can boost the current efficiency limit, which corresponds to approximately %22 in production, of crystalline silicon (c-Si) solar cells. Within the scope of this dissertation, extremely thin tunneling layers (1-3nm) of aluminum oxide is studied in conjunction with the development of wet cleaning procedures that are feasible in production lines currently exist today. These tunneling stacks are deployed to serve as exceptional surface passivation layers due to the inherent built-in charge provided by aluminum oxide. This capability is further strengthened by the introduction of extremely well controlled wet chemical …


A Multisystem Approach For The Characterization Of Bacteria For Sustainable Agriculture, Briana Lee Jan 2018

A Multisystem Approach For The Characterization Of Bacteria For Sustainable Agriculture, Briana Lee

Electronic Theses and Dissertations

The chemical, physical, and biological properties of bacteria developing resistance have been explored in animal based bacteria while plant bacteria have been largely neglected. Thus, the ability to probe changes in stiffness, adhesion, binding interactions and molecular traits of bacteria causing plant diseases is of great interest to develop a new generation of more potent, yet sustainable, pesticides. Our study aims to investigate the physical and chemical properties of bacterial systems, in particular their cell walls. Building upon this fundamental understanding of the cells, we also investigate the physicochemical responses associated to multivalent nanoparticle-based bactericide treatments on bacterial systems identified …


Seeing Living Things: Observations Of Figures From The Outside In, Forrest Deblois Jan 2018

Seeing Living Things: Observations Of Figures From The Outside In, Forrest Deblois

Electronic Theses and Dissertations

This writing accompanies the outcomes of my studio practice over the last three years, focusing on two bodies of work of paintings and drawings. In it I describe and analyze multiple influences tied to the progression and change in my studio practice. I began the process of my work with images and subjects from my home state of Florida, frequently juxtaposing the wildlife and humans, now I see this pattern as a byproduct of a studio practice functioning as a introspective reflection of what I experience, the things that I understand and the things that I don't. I deconstruct elements …


Searching For Home At Château De La Guette And Beyond: Social And Spatial Dimensions Of Jewish German And Austrian Children's Journey To Flee Nazi Persecution Via Children's Homes In France, Sarah Schneider Jan 2018

Searching For Home At Château De La Guette And Beyond: Social And Spatial Dimensions Of Jewish German And Austrian Children's Journey To Flee Nazi Persecution Via Children's Homes In France, Sarah Schneider

Electronic Theses and Dissertations

This study examines the experiences of a group of Jewish German and Austrian children who were sent on the Kindertransport to France in an effort to escape Nazi persecution. Using oral history interviews from the USC Shoah Foundation Visual History Archive, written testimonies, personal papers, and archival collections from organizations such as the OEuvre de Secours aux Enfants (OSE), this study analyzes the children's experiences at the Château de la Guette children's home in France and their subsequent time at the children's home Hôtel des Anglais in La Bourboule. This thesis examines the social and spatial dimensions of the children's …


Undergraduate Student Agreement With Reformed Introductory Physics Classes, Matthew Wilcox Jan 2018

Undergraduate Student Agreement With Reformed Introductory Physics Classes, Matthew Wilcox

Electronic Theses and Dissertations

In this study, I investigate student "buy-in", defined as students' proper understanding of and agreement with the class format, for introductory studio physics classes that incorporate lectures, labs, and group problem-solving activities into one interactive environment. I also investigate the ways in which instructors try to gain student buy-in to their class. Research has shown that student resistance to reformed instruction is a barrier to an instructor's use of research-based instructional strategies that are common to the studio class. Expectancy value theory suggests that by gaining student buy-in to the reformed class format, student resistance will decrease thus allowing a …


Risk Factors Associated With The Arrest For Adolescent To Parent Abuse, Coleen Cicale Jan 2018

Risk Factors Associated With The Arrest For Adolescent To Parent Abuse, Coleen Cicale

Electronic Theses and Dissertations

This study explored risk factors associated with the arrest for adolescent to parent abuse (ATPA) when compared to arrest for a similar violent misdemeanor against a non-parent. The phenomenon of ATPA is widely under-researched and there is little in terms of prevention policy or treatment. Using 18,548 risk assessment screens performed with adolescents (12-17) arrested in Florida for a violent misdemeanor, and guided by previous literature and social ecological and social bond theories, this analysis explored the relationship between risk factors (categorized as individual characteristics, beliefs, behavior, commitment and involvement and attachment) and arrest for ATPA versus arrest for a …


Investigations Of Possible Cases Of Scurvy In Juveniles From The Kellis 2 Cemetery In The Dakhleh Oasis, Egypt, Through Stable Carbon And Nitrogen Isotopic Analysis Of Multiple Tissues, Georgina Chasse Jan 2018

Investigations Of Possible Cases Of Scurvy In Juveniles From The Kellis 2 Cemetery In The Dakhleh Oasis, Egypt, Through Stable Carbon And Nitrogen Isotopic Analysis Of Multiple Tissues, Georgina Chasse

Electronic Theses and Dissertations

Vitamin C deficiency, or scurvy, is a disease that can occur in humans at any age and has been seen throughout time. Scurvy affects the production of connective tissues, including collagen, which leads to the many symptoms of the disease, including fatigue, anemia, bleeding gums and lost teeth, skeletal changes, and even death. The Kellis 2 cemetery in the Dakhleh Oasis, Egypt, in use from approximately AD 50-360, contains the remains of many juveniles who exhibit skeletal indicators of scurvy. Tissue samples from juveniles who did (n=31) and did not (n=117) exhibit skeletal indicators of scurvy were analyzed isotopically, with …


An Examination Of The Insights And Support Of Self-Advocacy By Academic Advisors When Working With Students With Disabilities In Higher Education, Jennifer Farran Jan 2018

An Examination Of The Insights And Support Of Self-Advocacy By Academic Advisors When Working With Students With Disabilities In Higher Education, Jennifer Farran

Electronic Theses and Dissertations

Self-advocacy for students with disabilities was noted throughout the literature as a necessary element for student success (Brinckerhoff, 1996; Daly-Cano, Vaccaro, & Newman, 2015; Gould, 1986; Williams & Shoultz, 1982). The literature also found that self-advocacy was particular crucial as students entered higher education (English, 1997; Stodden, Conway, and Chang, 2003; Vaccaro, Daly-Cano & Newman, 2015). In regard to student persistence, academic advising was the most cited student service (Hossler & Bean, 1990). Academic advisors assist students through their academic journeys and are tasked with assisting students to navigate college life (Kuh, 2008). However, there was a lack of research …


Understanding The Perceived Experiences Of Goal Setting Of Mothers Of Preschool Children: A Narrative Analysis, Dawn Eckhoff Jan 2018

Understanding The Perceived Experiences Of Goal Setting Of Mothers Of Preschool Children: A Narrative Analysis, Dawn Eckhoff

Electronic Theses and Dissertations

Mothers are often asked to use goal setting to help their children achieve optimal health. Before mothers can be successful, they must grasp the meaning and process of goal setting. Currently there is a glaring lack of published research regarding how goal setting is understood and experienced by mothers. The purpose of this qualitative study was to examine the self-described understanding and experiences of mothers, regarding goal setting for their preschool children. Narrative Inquiry was used to explore mothers' experiences with goal setting. A purposive sample of mothers with children in a Voluntary Pre-Kindergarten program were recruited from the central …


Social Media Usage By Municipal Elected Officials For Open Government Community Engagement, Sarah Stoeckel Jan 2018

Social Media Usage By Municipal Elected Officials For Open Government Community Engagement, Sarah Stoeckel

Electronic Theses and Dissertations

As public administration has evolved with the technological advances in today's society, it can be challenging to ensure the demands of the public are being met in terms of efficiency, effectiveness, and engagement. Nonetheless, a focus on community remains at the forefront of public administration. When looking at technology and the community, the tool known as social media emerges. Social media has allowed people to interact in new ways and therefore, has allowed the government to interact with citizens in ways they have not been able to in the past. In addition to attempting to modernize public administration, there has …


Procedural Justice And Police Officers: The Forgotten Perspective, Kirby Laura Rhodes Jan 2018

Procedural Justice And Police Officers: The Forgotten Perspective, Kirby Laura Rhodes

Electronic Theses and Dissertations

In recent years, there has been increased attention to questions about police legitimacy and the expectation of citizen compliance. Some scholars argue that procedurally just practices benefit police-citizen interactions (see Mazerolle et al., 2012, 2013). While there are many studies that focus on procedural justice and its effects on the civilian population, there is little research on police officers’ willingness to implement procedurally just practices. This study evaluates police officer perceptions of and willingness to engage in procedural justice using factor analytic techniques. There are four major findings: 1) Police officers are willing to engage in procedural justice, 2) police …


On The Design Of Physical Layer Rateless Codes, Amrit Kharel Jan 2018

On The Design Of Physical Layer Rateless Codes, Amrit Kharel

Electronic Theses and Dissertations

Codes that are capable of generating any number of encoded symbols from a given number of source symbols are called rateless codes. Luby transform (LT) codes are the first practical realization of rateless codes while Raptor codes are constructed by serially concatenating LT codes with high-rate outer low-density parity-check (LDPC) codes. Although these codes were originally developed for binary erasure channel (BEC), due to their rateless feature, they are being investigated and designed for their use in noisy channels. It is known that LT codes are the irregular non-systematic rateless counterpart of low-density generator-matrix (LDGM) codes. Therefore, the first part …


Freedom At The Freak Show: Carnivalesque Imagery In The Fiction Of Eudora Welty, Flannery O'Connor And Katherine Anne Porter, Virginia Mccarley Jan 2018

Freedom At The Freak Show: Carnivalesque Imagery In The Fiction Of Eudora Welty, Flannery O'Connor And Katherine Anne Porter, Virginia Mccarley

Electronic Theses and Dissertations

This thesis examines the function of the circus and the sideshow in the work of Eudora Welty, Flannery O’Connor, and Katherine Anne Porter, arguing that all of these authors employ Mikhail Bakhtin’s idea of the carnivalesque as a reaction to and against the expectations put on them as women who are pressured to conform to the Southern ideal. In the first chapter, I argue that Eudora Welty uses the carnivalesque to reveal the performativity of normalcy in both “Lily Daw and the Three Ladies” (1937) and “A Memory” (1937). These performances, in the first story particularly, offer a critique of …


Impulsion, Nicholas Meyer Jan 2018

Impulsion, Nicholas Meyer

Electronic Theses and Dissertations

The nut, bolt, and thread are symbols of order in my work. They represent a memory trace of my time growing up in Iowa and my connection to working on the family farm. These objects have the potential to exhibit elements of both simplicity and complexity, expressed through patterns and harmony, and the repetition of form, line, color, space, presentation, and ultimately, their relation to you the viewer. With this body of work, I intend to create metaphors relating to connections people have to one another, as individuals, society and ultimately as a reflection of self. The act of grouping, …


Food Insecurity And Child And Parent/Caretaker Overweight/Obesity In A Rural, Appalachian Mississippi Community, Sydney Antolini Jan 2018

Food Insecurity And Child And Parent/Caretaker Overweight/Obesity In A Rural, Appalachian Mississippi Community, Sydney Antolini

Electronic Theses and Dissertations

This study examined the differences in parent/caretaker body mass index (BMI) and parent/caretaker-reported child overweight/obesity by food security status in a rural, Appalachian, Mississippi community, as well as the relationship of parent/caretaker BMI and parent/caretaker-reported child overweight/obesity to food security status. A cross-sectional survey of elementary school parents/caretakers recruited at three elementary schools in an economically-distressed Appalachian, Mississippi county was conducted. Parent/caretaker BMI was calculated from self-reported height and weight. Caretaker-reported child overweight/obesity was determined using caretaker report of a medical professional identifying child overweight/obesity within the past year. Data were analyzed using IBM SPSS (version 23, 2015) to assess …