Digital Commons Network^™

Fabrication And Characterization Of Amlodipine Besylate Based Sub-Cutaneous Implants: Fabricated With The Help Of Hot Melt Extrusion, Kshitij Chitnis

Electronic Theses and Dissertations

Hypertension (HTN) can lead to heart attack, cardiac arrest, or coronary heart disease, and eventually death without proper treatment. Amlodipine Besylate (AMB) was approved by, US Food and Drug Administration in 1987, as a monotherapy for the management of HTN. AMB is commercially available in tablet (2.5, 5, and 10 mg) and solution (1mg/mL) dosage forms. However, adherence to the properly prescribed dosage form is critical and difficult for patients with chronic diseases such as HTN to prevent illness progression and death. The objective of the study was to develop AMB-loaded subcutaneous implants to reduce the frequency of administration, thus, …

Formulation And Evaluation Of Prochlorperazine Maleate Sustained Release Mucoadhesive Buccal Films Using Hot Melt Extrusion, Umesh Chandra Chowdary Devineni

Electronic Theses and Dissertations

Many patients find it difficult to swallow tablets or hard gelatin capsules and fail to comply with prescriptions, resulting in a high incidence of noncompliance and ineffective treatment. Well, in recent years, buccal drug delivery has gained significant attention as a potential alternative to traditional drug delivery systems. Prochlorperazine Maleate is a widely used antiemetic drug for treating nausea and vomiting caused by various medical conditions. However, its oral administration is associated with poor bioavailability and inconsistent therapeutic effects. To overcome these limitations this study aims to develop sustained release mucoadhesive buccal films of Prochlorperazine Maleate using the Hot Melt …

Adversarial Explanations For Text-Based Local Surrogate Models, Christopher Burger

Electronic Theses and Dissertations

LIME has emerged as one of the most commonly referenced tools in explainable AI (XAI) frameworks that is integrated into critical machine learning applications–e.g., healthcare and finance. However, its stability remains little explored, especially in the context of text data, due to the unique challenges when it comes to perturbing the underlying data, data that requires a stricter measure of semantic and syntactic consistency. To address these challenges, we first evaluate the inherent instability of LIME on text data to establish a baseline, and then propose a novel algorithm XAIFOOLER to perturb text inputs and manipulate explanations that casts investigation …

The Enduring Tradition Of Toxic Masculinity In French Literature, Hailey Caroline Kaim

Electronic Theses and Dissertations

Toxic masculinity, the modern definition has given a concise explanation to what French literature has been relaying to audiences for centuries. This thesis will explore how toxic masculinity is seen in French literature through five time periods: the Medieval era, 17th, 18th, 20th, and 21st century. Introducing toxic masculinity is provided by a modern definition, biological evidence, and evaluation with society’s definition of masculinity. The Medieval era will investigate two short stories of courtly love that provide readers with classical examples of toxic masculinity that both men and women displayed. Venturing into the 17th and 18th centuries, plays brought the …

Photophysical Characterization Of Small Organic Molecules Via Time-Resolved And Steady-State Spectroscopic Techniques, Cameron Luke Smith

Electronic Theses and Dissertations

This dissertation describes in detail the photophysical characterization of novel organic dyes in the infrared region for bioimaging purposes in a rapidly evolving field which originates from the need for more efficient and bright systems that are capable of replacing current commercial options and functioning in biologically relevant media. Biological tissue, whether it be muscle, adipose, or epithelium, has a higher scattering efficiency, greater light attenuation, and stronger autofluorescence at shorter wavelengths, thus limiting the biological window to longer wavelengths. The goal of this dissertation was the comparison of novel organic dyes for commercial development as bioimaging dye candidates with …

Leadership Matters: An Assessment Of The Mpower Leadership Program At The University Of Mississippi, Ryan Upshaw

Electronic Theses and Dissertations

The purpose of this manuscript is to examine the importance of student leadership development programs on undergraduate students using the framework of the Social Change Leadership Model. This document will specifically examine the MPower Leadership program held at the University of Mississippi. Student engagement and leadership is extremely important to college campuses as universities seek to prepare their students for the world of work and to become engaged citizens. Student leadership and engagement also has ties to academic success and persistence. A concrete plan that is focused on leadership development also benefits student affairs administrators who are responsible for coordinating, …

Exploration Of Student Success Programs For Freshmen Students On Academic Warning/Academic Probation At The University Of Mississippi, Jeremy Roberts

Electronic Theses and Dissertations

Nearly ten percent of the first-year class at the University of Mississippi go on Academic Warning or Academic Probation each semester after their first-full semester at the University. During this time, the student's GPA is below a 2.0, which requires them to take the EDHE 101: Academic Skills for College course, if they plan to return to the University that following Spring or Fall semester (depending on which was their first-full semester). Academic Support Programs, under the Center for Student Success and First-Year Experience oversees this course and several other programs to assist students as they look to return to …

Entrepreneurs Want More Than Just Money: The Role Of Subjective Entrepreneurial Success In Predicting Entrepreneur’S Grief Following Venture Failure, Joseph Richard Schaefer

Electronic Theses and Dissertations

The focal topics of this dissertation are subjective entrepreneurial success (SES) and grief. Over the past three decades, the budding SES literature has seen accelerating growth since its conceptual inception in 1987, with 2016 marking a key event in the literature – the formal naming and definition of the SES construct. Research on the SES construct is of interest to scholars because it complements the objective economic conceptualizations of success often seen in the entrepreneurship literature, highlighting the idiosyncratic ways that entrepreneurs conceptualize and evaluate their success.

To contribute to the SES literature, Essay One of my three-essay dissertation, I …

Novel Delivery Systems Of Curcumin And Resveratrol, Mohamed Salem Elfaruk

Electronic Theses and Dissertations

No abstract provided.

Seroprevalence Of Sars-Cov-2 Antibodies Among Rural Healthcare Workers, Jordan Neises

Electronic Theses and Dissertations

The objective of this longitudinal cohort study was to determine the seroprevalence of antibodies to severe acute respiratory syndrome coronavirus-2 (SARSCoV- 2) in healthcare workers employed at healthcare clinics in three rural counties in eastern South Dakota and western Minnesota from May 13, 2020 through December 22, 2020. Three blood draws were performed at five clinical sites and tested for the presence of antibodies against the SARS-CoV-2 virus. Serum samples were tested for the presence of antibodies using a fluorescent microsphere immunoassay (FMIA), neutralization of SARS-CoV-2 Spike-pseudotyped particles (SARS-CoV-2pp) assay, and serum virus neutralization (SVN) assay. The seroprevalence was determined …

Building No-Tillage Maize Nitrogen Recommendation Algorithm That Considers Improvements In Soil Health, Dwarika Bhattarai

Electronic Theses and Dissertations

In long-term no-till fields, farmers have reported that less N is required to optimize maize (Zea mays L.) yields in long term no-tillage fields than conventional tillage fields. These reductions may be attributed to improved soil health resulting from increasing soil organic matter, higher soil microbial activities, and improved water and nutrient use efficiency. However, the impact of soil health measurements on fertilizer-N requirement has not been determined. The objective of this dissertation was to compare different regional N recommendation models to measured values and develop a maize fertilizer-N recommendation model, using machine learning approaches, that includes adjustments based on …

Impact Of Virtual Fence Technology On Yearling Steer Behavior, Performance, And Energetic Expenditure, Logan Riley Vandermark

Electronic Theses and Dissertations

Beef cattle production in the U.S. is largely dependent upon extensive rangelands like the Northern Great Plains. Solutions are needed to meet both the demand of animal-based protein products for a growing world population and the desire for producers to manage for several different ecosystem functions. Virtual fencing (VF) is an emerging precision technology that has the potential to revolutionize livestock management on extensive rangeland systems. However, the need to quantify animal behavior and performance differences using emerging precision technologies, like VenceTM, is ever growing. Thus, the objective of this research was to determine the impact of virtual fencing on …

Fighting For What Is Right: A Rhetorical Analysis Of The Fan Campaign To Save Anne With An E From Cancellation, Marie E. Anderson

Electronic Theses and Dissertations

The Anne with an E fan campaign highlighted storylines of social issues that fans felt were important for society. Of particular interest to the fan community was a storyline from the series in which Anne and her friends organized a protest following incidents of sexual assault and censorship aimed at silencing girls from speaking out on gendered issues. This storyline was heavily referenced in the billboards that the fan-based campaign displayed in Toronto and New York City (Anne Nation, 2020). In this analysis, I used fantasy theme analysis (Bormann, 1972) and metaphorical criticism (Osborn, 2018) to conduct a visual and …

The Effects Of Body Weight, Feed Intake, And Weather On Total And Liquid Water Intake In Growing Beef Cattle, Madison Rae Kovarna

Electronic Theses and Dissertations

Research conducted in the 1950s to determine water requirements utilized cattle that vary greatly from the animals being raised today. Additionally, most of the previous research has been conducted on animals being fed for slaughter, rather than bulls or reproductive females. The objective of this study was to analyze the effect of weather variables, dry matter intake (DMI), and body weight (BW) on total daily water intake (TDWI) and liquid daily water intake (LDWI) in growing beef bulls and heifers. Two contemporary groups of Angus and Simmental x Angus bulls and heifers over a two-year period were utilized in this …

The Crisis Of White Supremacy In The Antebellum South: Poor Whites, Slavery, And The Coming Of The Civil War, Jeffrey Glossner

Electronic Theses and Dissertations

The so-called “poor whites” of the antebellum South have often been overlooked by historians due to their perceived insignificance to the political and cultural development of the South. However, within the context of the sectional debate over slavery, poor whites represented a disturbing presence for elite southerners who sought to defend slavery on the basis of white supremacy, a political platform built on the promise of universal white superiority. In order to defend the slave labor system from northern promises of white supremacy under free labor and to justify widespread southern white poverty, the architects of the antebellum southern cultural …

Dark Personality, Sexual Satisfaction And Sexual Perceptions: An Event-Contingent Study, Jasmine Whitney Rios

Electronic Theses and Dissertations

Research has consistently linked Dark Personality (DP) to one’s mating tendencies (e.g., mating strategy, sexual behavior, sociosexual orientation) and sexual motivation. However, DP researchers have failed to expand the association between DP and sex beyond these common sexual dimensions. As such, there is little to no research linking DP to people’s sexual satisfaction and sexual perceptions. Additionally, personality research has predominantly investigated sexuality at the global-level (e.g., average/general report of sexual satisfaction) when studying aspects of sexual interaction at the interaction-level (i.e., soon after the interaction) can reduce various issues that accompany global measures. Thus, one purpose of this current …

Enhancing Student Engagement: Regional Campus Students’ Access To High Impact Practices And Co-Curricular Organizations, Angela Kristina Austin

Electronic Theses and Dissertations

Regional campuses serve a vital role in today's higher education landscape, extending access to college education for underserved locations and populations. The University of Mississippi’s university system has five regional campuses. The students at a regional campus, like their traditional main campus counterparts, aspire to attain bachelor's or graduate degrees. However, regional campus students often exhibit characteristics more akin to community college or non-traditional students.

While literature on regional campuses is limited, ample research supports the positive impact of student involvement in higher education. Even more limited is research on participation levels of non-traditional students in co-curricular organizations and high-impact …

Saudi Perspective On Using Efl Resources To Improve Their English Pronunciation In Saudi Public Institutions, Khadija Abdullah Alzahrani

Electronic Theses and Dissertations

Due to the lack of a pronunciation curriculum and materials in Saudi universities, EFL students individually select use different resources to help with their English pronunciation difficulties. Therefore, this study aims to describe (a) Saudi students' perspectives and attitudes toward pronunciation resources that may help with their pronunciation (b) if they use them to help with their weaknesses, and (c) the teachers’ perspectives on their students' pronunciation difficulties, their knowledge of the resources the universities provide, and what they use to help the students' pronunciation learning and development. This study investigates what Saudi students think they need to learn pronunciation, …

Solubility Enhancement Of Atorvastatin Calcium Using Cyclodextrin, Karthik Abburi

Electronic Theses and Dissertations

The present study is intended to increase the solubility and dissolution rate of Atorvastatin calcium (ATN Ca) by formulating the drug- hydroxy-propyl-beta cyclodextrin (HPBCD) complexes using solvent-assisted extrusion (SAE) using a twin-screw extruder. Various studies on ATN Ca saturation solubility in water and other pH mediums revealed a pH-dependent solubility with a difference. Thus, the saturation solubility for ATN Ca and Solvent Assisted Extruded complex was conducted in water and different pH mediums in this study. Phase solubility studies between ATN Ca and CDs revealed an AL-type solubility profile exhibiting a linear increase with HPBCD. Drug-HPBCD complexes were made using …

Level Of Pj (Peace Journalism) Awareness Among Journalists From Saudi Arabia, Abdullah Ayidh J. Alqahtani

Electronic Theses and Dissertations

This study aimed to ascertain whether Saudi Arabian journalists know peace journalism. According to the peace journalism model and the framing theory, journalists' practices are supposed to foster peace rather than fuel violence. As a result, journalists can shed light on the social and underlying causes of violence with the noble goal of demoting violence and promoting peace. In that sense, 100 journalists from Saudi Arabia made up the sample population of this study. The mixed-method approach was used to collect data; Consequently, the researcher provided the participants with a questionnaire to elicit the level of awareness of peace journalism …

"It's My Job:" Graduate Student Socialization And Career Choice, Megan Black

Electronic Theses and Dissertations

The purpose of planning this evaluation is to explore perspectives of graduate student socialization to practitioner careers in students’ fields of study. Socialization in graduate programs refers to the process by which students learn and adapt to the norms and expectations of their anticipated career fields, and the activities within programs that provide related information and practice. Higher education in the United States has been undergoing a long-term change in which full-time, tenured faculty positions are becoming increasingly rare, with many new doctoral graduates relegated to non-tenure track adjunct positions. Also of note is the growing number of doctoral students …

Academic Medical Center Governance: A Study Focused On The University Of Mississippi Medical Center, Jacob Daniels

Electronic Theses and Dissertations

Academic Medical Centers (AMCs) face many challenges, which can lead to financial constraints. For AMCs to remain sustainable in today’s healthcare system, the literature presents a compelling case for expansion to mitigate their financial burdens. Expansion often requires quick decision-making, and as a result, scholars repeatedly discuss the importance of AMC governance being both nimble and efficient. The University of Mississippi Medical Center (UMMC) substantially impacts Mississippians, and the institution must remain a thriving center for education, research, and healthcare for the state. Given the importance of efficient and nimble governance in the institution’s sustainability, this Dissertation in Practice (DiP) …

Adolescent Health And Maladaptive Coping: Assessing The Relationship Between Poor Physical Health And Underage Drinking, Shelby Gilbreath

Electronic Theses and Dissertations

Adolescents endure various stressors throughout their lives, making them one of the most vulnerable populations in the United States. Among those life stressors are physical health issues, including physical illness and disabilities. Physical health challenges may serve as a strain that fosters deviant behavior, such as underage drinking. However, prior research has failed to investigate this relationship. The current study uses publicly available data from the National Study of Adolescent to Adult Health (Add Health) to examine the impact of physical health challenges on underage drinking.

"Dug Way To Liberty": Newspapers, Prison, And Jim Crow In Georgia In The Early 1900s, Avery Elise Gross

Electronic Theses and Dissertations

On April 15, 1907, twelve Black and white convicts escaped from the Durham Mines prison camp located on Lookout Mountain, Georgia. Over the next month, newspapers throughout Georgia and in neighboring states reported the escape and discussed the recapture events. Within five days of the prison break, the local white community recaptured all nine Black convicts. None of the white convicts were caught. As this thesis investigates the lives, crimes, and recapture of all twelve prisoners, it connects the convict lease prison system with the newspaper media to understand the impact of white supremacy ideology and the repressive systems that …

“Mississippi’S Greatest Minister”: A Historical Study Of Cornelius W. Grafton’S 61-Year Pastorate, 1873-1934, David Thomas Irving

Electronic Theses and Dissertations

Cornelius W. Grafton (b.1846, d.1934) pastored two Presbyterian churches in Southwest Mississippi for 61 consecutive years (1873-1934). He moderated the Presbyterian Church, U.S. General Assembly in 1916 and wrote a 658-page unpublished History of Presbyterianism in Mississippi. This dissertation studies Grafton’s ministry—his student years at the University of Mississippi and Columbia Theological Seminary, his sermons, his public opposition to lynching, and his periodical and historical writings—to understand how white Christians in the South thought of and responded to their context from Reconstruction through the Progressive Era and into the 1930’s. Many of the priorities of Grafton’s ministry corresponded to those …

Effects And Mechanisms Of Cognitive Impairment During Vigorous-Intensity Exercise, Myungjin Jung

Electronic Theses and Dissertations

Recent research indicates that vigorous-intensity exercise concurrent with a prefrontal cortex (PFC)-dependent cognitive task can temporarily deactivate the PFC, leading to impaired cognition. Shifting attentional focus from a cognitive task to exercise or vice versa during exercise may also affect cognitive performance. However, the underlying mechanisms of this effect remain unclear. Therefore, this dissertation aimed to evaluate whether changes in attention and PFC oxygenation mediate cognitive impairment during vigorous-intensity exercise. Seventy-five young healthy adults (37 males, 38 females; 20.3 ± 1.6 years) completed three visits. The initial visit consisted of a max cycle test to measure VO2max via indirect calorimetry. …

Fte2: An Exploration Of Full-Time Employed, Full-Time Enrolled Undergraduate Student Perceptions Regarding The Impact Of Support Systems On Their Ability To Persist, Victoria Lauren Mccord

Electronic Theses and Dissertations

Full-time enrolled students participating in full-time employment is a growing trend on college campuses. This dissertation serves to explore the perceptions of full-time employed, full-time enrolled graduate students’ perceptions on the impact of their support systems on their ability to persist. The proposed study utilizes Laura Perna’s Conceptual Model for College Access and Choice (2006), along with Cabrera, Nora, and Castenada’s Integrated Model for Student Retention (1993) to the following research questions: (1) What factors, support systems or resources do students utilize? (2) What formal or informal support systems and/or resources aid in student persistence, if any? This dissertation addresses …

Formulation Development And Evaluation Of Cannabidiol Hot Melt Extruded Solid Self-Emulsifying Drug Delivery System For Oral Applications, Kavish Dilip Sanil

Electronic Theses and Dissertations

Cannabidiol (CBD) is a highly lipophilic compound with poor oral bioavailability, due to poor aqueous solubility and extensive pre-systemic metabolism. The aim of this study was to explore the potential of employing Hot Melt Extrusion (HME) technology for the continuous production of Self Emulsifying Drug Delivery Systems (SEDDS) to improve the solubility and in vitro dissolution performance of CBD. Accordingly, different placebos were processed through HME in order to obtain a lead CBD loaded solid SEDDS. Two SEDDS were prepared with sesame oil, Poloxamer 188, Gelucire®59/14, PEO N80 and Soluplus®. Moreover, Vitamin E was added as an antioxidant. Both SEDDS …

A Care Ethical Defense Of Intergenerational Obligations, Owen Spalding

Electronic Theses and Dissertations

This paper argues that an ethic of care can justify an obligation or set of obligations to future generations. To do this, I analyze a comparable project by Thomas Randall and while ultimately agreeing with his basic conclusion, I show that he needlessly rejects arguments that would help to establish this obligation. Specifically, I defend against his critiques of Nel Noddings and Anca Gheaus. From here, I move on to show that an ethic of care centered on needs is more effective for making policy decisions than the sufficientarian model established by Randall.

Assessing The Relationship Between School Disengagement And Violence Involvement, Senneca Evans

Electronic Theses and Dissertations

Social control theory suggests that having strong social bonds to a society prevents individuals from engaging in delinquent acts. Consistent with the main assumption of this theoretical framework, the current study assesses whether having a weak bond to school, specifically, school disengagement, impacts violent behavior among adolescents. The current study also assesses whether gender and race/ethnicity moderate the relationship between school disengagement and violence involvement. Data used in this study were obtained from the National Longitudinal Study of Adolescents to Adult Health public-use data (N = 6,045). Results show that school disengagement is a significant predictor of violent behavior among …