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Identification Of Proteins Regulating Vldl Sorting Into The Vldl Transport Vesicle (Vtv) And Involved In The Biogenesis Of The Vtv, Samata Tiwari

Electronic Theses and Dissertations

Increased secretion of very low-density lipoprotein (VLDL), a triglyceride-rich lipoprotein, by the liver causes hypertriglyceridemia, which is a major risk factor for the development of atherosclerosis. The rate of VLDL-secretion from the liver is determined by its controlled transport from the endoplasmic reticulum (ER) to the Golgi. The ER-to-Golgi transport of newly synthesized VLDL is a complex multi-step process and is mediated by the VLDL transport vesicle (VTV). Once a nascent VLDL particle is synthesized in the lumen of the ER, it triggers the process of VTV-biogenesis and this process requires coat complex II (COPII) proteins that mediate the formation …

Role Of Host Immune Response And Bacterial Autolysin Atl In Human Nasal Colonization By Staphylococcus Aureus, Vanathy Paramanandam

Electronic Theses and Dissertations

Staphylococcus aureus (SA) is a major human pathogen that colonizes the anterior nares in 30% of the human population. Though nasal carriage of SA is a known risk factor for the subsequent spread of SA infections, the dynamics of SA nasal colonization is poorly understood. Our research focuses on understanding the host and bacterial factors that might contribute to the human nasal colonization by SA. In an attempt to elucidate the host response to SA, we performed an autologous human in vivo nasal colonization study, which showed decreased survival rates of SA in hosts who elicited a robust immune response. …

A Randomized Trial Of Attention Training For Generalized Social Phobia: Does Attention Training Change Social Behavior?, Brian Bunnell

Electronic Theses and Dissertations

The use of attention training protocols for the treatment of generalized social anxiety disorder (SAD) is undergoing increased examination. Initial investigations were positive but more recent investigations have been less supportive of the treatment paradigm. One significant limitation of current investigations may be over-reliance on self-report. In this investigation, we expanded on initial investigations by using a multimodal assessment of patient functioning (i.e., including behavioral assessment). Patients with a primary diagnosis of SAD (n = 31) were randomly assigned to eight sessions of attention training (n = 15) or placebo/control (n = 16). Participants were assessed at pre- and post-treatment …

Biochemical Characterization Of The Nifb Enzyme And Nifb-Cofactor, Jirair Gevorkyan

Electronic Theses and Dissertations

The Mo-nitrogenase complex is composed of two components, Fe-protein and MoFe-protein. This complex is able to catalyze the reduction of N2 through the MgATP dependent transfer of electrons from the Fe-protein Fe4S4 cluster to the MoFe-protein P-cluster and, subsequently, to the iron-molybdenum cofactor (FeMoco). FeMo-co is a Fe7S9MoC-(R)-homocitrate cluster and has two biosynthetic precursors, NifB-co and L-cluster, of unknown structure and composition. The biosynthesis of FeMo-co is an enigmatic process that minimally requires NifB, NifEN, Fe-protein, MoO4 2- , (R)-homocitrate and S-adenolsylmethionine. A means to isolate the NifB enzyme for characterization has been developed through use of a GST-fusion tag. …

Examining Relationships Among Levels Of Victimization, Perpetration, And Attitudinal Acceptance Of Same-Sex Intimate Partner Violence In Lesbian, Gay, Bisexual, Transgender, And Queer College Students, Elizabeth Jacobson

Electronic Theses and Dissertations

The Centers for Disease Control and Prevention (CDC; 2012) reported that intimate partner violence (IPV) affects approximately 4.8 million females and 2.8 million males in their intimate relationships each year. Past research (e.g., Fanslow, Robinson, Crengle, & Perese, 2010; Foshee et al., 1996; Foshee et al., 2009) on IPV solely evaluated prevalence rates and factors within opposite-sex relationships; however, IPV within lesbian, gay, bisexual, transgender, and queer (LGBTQ) individuals' relationships exists at equal, if not higher, rates compared to their heterosexual counterparts (Alexander, 2008; McKenry, Serovich, Mason, & Mosak, 2006). Subsequently, a gap in research existed on violence in LGBTQ …

Showcasing Self: An Intersectional Analysis Of Body Type Presentation In Online Daters, Andrew Latinsky

Electronic Theses and Dissertations

Using data collected from the online dating site Match.com, this paper performs a content analysis examining the relationships between race, gender, and sexuality as both independent variables and as intersections on impression management strategies in online dating. Impression management strategies form a foundational core of how people interact with others in social situations. This analysis focuses on impression management strategies by examining how people advertise their body type in a public arena. Analysis also draws upon the types of bodies these people desire in an ideal date, as a second method of looking at the norms surrounding the ideal body …

The Contribution Of Practicing School Counselors' Level Of Altruism To Their Degree Of Burnout, Dorothy Limberg

Electronic Theses and Dissertations

The present study investigated the directional relationship between practicing school counselors’ level of altruism to their degree of burnout. Specifically, this investigation tested the hypothesized directional relationship that practicing school counselors scoring at higher levels of altruism would have lower levels of burnout (emotional exhaustion, depersonalization, personal accomplishment). In addition, the investigation examined the relationship between the practicing school counselors’ levels altruism and burnout and their reported demographic information (e.g., age, school counseling level, self-reported levels of wellness). A thorough review of the literature is presented with supporting empirical research for each construct (altruism and burnout). A descriptive, correlational research …

Measurement Of Negative Affectivity In Psychometrically Defined Schizotypy Using Facial Electromyography, Jonathan Mitchell

Electronic Theses and Dissertations

Schizotypy is a sub-threshold syndrome associated with schizophrenia. Much of the research on schizotypy concerns its component features, one of which being blunted or constricted affect. While several investigations have addressed this common “negative” symptom within the context of schizophrenia, few have focused on schizotypy directly, and none have utilized psychophysiological measurement to examine affective constriction. The present investigation uses facial electromyography (EMG) to measure patterns of affective expression within a psychometrically defined schizotypal population when presented threatening and distressing pictures from the IAPS. Twenty-eight individuals with elevated schizotypal features and 20 healthy controls were recruited for this investigation. The …

Investigating The Relationship Between Adverse Events And Infrastructure Development In An Active War Theater Using Soft Computing Techniques, Erman Cakit

Electronic Theses and Dissertations

The military recently recognized the importance of taking sociocultural factors into consideration. Therefore, Human Social Culture Behavior (HSCB) modeling has been getting much attention in current and future operational requirements to successfully understand the effects of social and cultural factors on human behavior. There are different kinds of modeling approaches to the data that are being used in this field and so far none of them has been widely accepted. HSCB modeling needs the capability to represent complex, ill-defined, and imprecise concepts, and soft computing modeling can deal with these concepts. There is currently no study on the use of …

Biomechanical Factors Influencing Treatment Of Developmental Dysplasia Of The Hip (Ddh) With The Pavlik Harness, Orlando Ardila

Electronic Theses and Dissertations

Biomechanical factors influencing the reduction of dislocated hips with the Pavlik harness in patients of Developmental Dysplasia of the Hip (DDH) were studied using a simplified three-dimensional computer model simulating hip reduction dynamics in (1) subluxated, and (2) fully dislocated hip joints. The CT-scans of a 6 month-old female infant were used to measure the geometrical features of the hip joint including acetabular and femoral head diameter, acetabular depth, and geometry of the acetabular labrum, using the medical segmentation software Mimics. The lower extremity was modeled by three segments: thigh, leg, and foot. The mass and the location of the …

Go Fish: An Analysis Of Economic Rents In Panamanian Fisheries Against Ecosystem Service Values, David Glassner

Electronic Theses and Dissertations

Global demand of fish for consumption in developing nations is expected to continue to rise in the near future, putting pressure on stocks that are already overexploited. In the territorial waters of Panama there is a constant struggle between commercial vessels with high yield, subsistence fishermen trying to feed a remote village, and ecosystem services struggling to sustain themselves. These services are the direct and indirect benefits received by the population in the form of food, raw materials, nutrient cycling, and disaster regulation. They are being degraded by illegal and unregulated fishing, bottom trawlers raking the benthos and destroying coral …

The Study Of Photo-Reduction Of Cerium Oxide Nanoparticles In Presence Of Dextran: An Attempt In Understanding The Functionality Of The System, Swetha Barkam

Electronic Theses and Dissertations

Malignant melanoma cancer is the sixth common cancer diagnosed in the United States. Surgery, chemotherapy and radiation are some of the successful techniques in killing tumor cells. However, in these techniques, it is not easy to distinguish tumor cells from the healthy once which inadvertently get exposed to chemical agent/radiation. Therefore it is required to develop an anticancer agent which selectively kills the cancer cells, while still protecting the normal tissues. In our preliminary work, we have shown that Dextran (1000Da) coated Cerium oxide nanoparticles (Dex-CNPs) selectively kills the cancer cells (50% killing at a concentration of 150μM) without inducing …

Chemophysical Characteristics And Application Of Biosorption Activated Media (Bam) For Copper And Nutrient Removal In Stormwater Management, Jamie Jones

Electronic Theses and Dissertations

For high groundwater table areas, stormwater wet detention ponds are utilized as the preferred stormwater management throughout the state of Florida. Previous research has found that accumulations of nutrients, algae, heavy metals, pesticides, chlorophyll a, fecal coliform bacteria and low concentrations of dissolved oxygen (DO) are common characteristics of stormwater wet detention ponds. Although these pollutant levels are not regulated within the ponds, states are required to compute the pollutant load reductions through total maximum daily load (TMDL) programs to meet the water quality requirements addressed by the Clean Water Act (CWA). In this study, field sampling data of stormwater …

Tailoring The Properties Of Polyelectrolyte Coated Cerium Oxide Nanoparticles As A Function Of Molecular Weight, Shashank Saraf

Electronic Theses and Dissertations

The application of Cerium oxide nanoparticles (CNPs) for therapeutic purposes requires a stable dispersion of nanoparticles in biological environment. The objective of this study is to tailor the properties of polyelectrolyte coated CNPs as a function of molecular weight to achieve a stable and catalytic active dispersion. This was achieved by coating CNPs with polyacrylic acid (PAA) which increased the dispersion stability of CNPs and enhanced the catalytic ability. The stability of PAA coating was analysed using the change in the Gibbs free energy computed by Langmuir adsorption model. The adsorption isotherms were determined using soft particle electrokinetics which overcomes …

Transient Multi-Scale Computational Fluid Dynamics (Cfd) Model For Thrombus Tracking In An Assit Device Vascular Bed, Ruben Osorio

Electronic Theses and Dissertations

Heart failure occurs when the heart is not capable to pump blood at a sufficient rate to meet the demands of the body. Depending on the health of the heart, doctors may recommend a heart transplant, but finding a suitable donor is often a long duration process and the patient might be at an advance condition or the patient is not adequate for a heart transplant. In such cases Ventricular assist devices (VAD) are implemented. The purpose of a VAD is to aid the heart to pump the correct amount of blood, by doing so it relives the load that …

Integrated Data Fusion And Mining (Idfm) Technique For Monitoring Water Quality In Large And Small Lakes, Benjamin Vannah

Electronic Theses and Dissertations

Monitoring water quality on a near-real-time basis to address water resources management and public health concerns in coupled natural systems and the built environment is by no means an easy task. Furthermore, this emerging societal challenge will continue to grow, due to the ever-increasing anthropogenic impacts upon surface waters. For example, urban growth and agricultural operations have led to an influx of nutrients into surface waters stimulating harmful algal bloom formation, and stormwater runoff from urban areas contributes to the accumulation of total organic carbon (TOC) in surface waters. TOC in surface waters is a known precursor of disinfection byproducts …

Economic Valuation Of Florida Sea Turtles In Face Of Sea Level Rise, Ahmed Hamed

Electronic Theses and Dissertations

Sea level rise (SLR) is posing a great risk of flooding and inundation to coastal areas in Florida. Some coastal nesting species, including sea turtle species, have experienced diminished habitat from SLR. In an effort to assess the economic and ecosystem service loss to coastal areas with respect to sea turtles Contingent Valuation Method (CVM) and Habitat Equivalency Analysis (HEA) were used. The CVM was used to measure the economic impacts of SLR on sea turtles. Open-ended and dichotomous choice CVM was used to obtain the willingness to pay (WTP) values of Florida residents to implement certain mitigation strategies which …

Assessment, Optimization, And Enhancement Of Ultrafiltration (Uf) Membrane Processes In Potable Water Treatment, Christopher Boyd

Electronic Theses and Dissertations

This dissertation reports on research related to ultrafiltration (UF) membranes in drinking water applications. A pilot-scale investigation identified seasonal surface water quality impacts on UF performance and resulted in the development of a dynamic chemically enhanced backwash protocol for fouling management. Subsequent analysis of UF process data revealed limitations with the use of specific flux, transmembrane pressure (TMP), and other normalization techniques for assessing UF process fouling. A new TMP balance approach is presented that identifies the pressure contribution of membrane fouling and structural changes, enables direct process performance comparisons at different operating fluxes, and distinguishes between physically and chemically …

How Emoticons Affect Leader-Member Exchange, Jennifer Loglia

Electronic Theses and Dissertations

Emoticons have been shown to be the nonverbal cues of computer-mediated communication and could therefore be a rich source of information, but they are not used in the workplace because they are considered unprofessional. This study aimed to look at the effects of emoticons on relationships, specifically between a leader and member. Participants were asked to read a fake email from a fake boss and answer several questions in regard to leader-member exchange, affective presence, perceived message positivity, perceived masculinity/femininity of the fake boss, and perceived professionalism. This study found that the use of a positive emoticon in an email …

Three-Phase Contact Line Phenomena In Droplets On Solid And Liquid Surfaces: Electrocapillary, Pinning, Wetting Line Velocity Effect, And Free Liquid Surface Deformation, Roxana Shabani

Electronic Theses and Dissertations

In this dissertation physical phenomena relevant to (i) an interface formed between two fluids and a solid phase (wetting line) and (ii) an interface between three fluids (triple contact line) were investigated. In the former case, the wetting line (WL) phenomena which encompass the wetting line energy (WLE) or pinning, the wetting line velocity (WLV), and the contact angle hysteresis, were studied using a micropump based on electrowetting on dielectric (EWOD). In the latter case, the interfacial phenomena such as the air film lubrication effect and the liquid free surface deformation were taken into account to explain the dual equilibrium …

Bio-Inspired, Varying Manifold Based Method With Enhanced Initial Guess Strategies For Single Vehicle's Optimal Trajectory Planning, Ni Li

Electronic Theses and Dissertations

Trajectory planning is important in many applications involving unmanned aerial vehicles, underwater vehicles, spacecraft, and industrial manipulators. It is still a challenging task to rapidly find an optimal trajectory while taking into account dynamic and environmental constraints. In this dissertation, a unified, varying manifold based optimal trajectory planning method inspired by several predator-prey relationships is investigated to tackle this challenging problem. Biological species, such as hoverflies, ants, and bats, have developed many efficient hunting strategies. It is hypothesized that these types of predators only move along paths in a carefully selected manifold based on the prey’s motion in some of …

Evaluation Of The Biodegradability And Toxicity Of Pca And Mpca, Juan Rueda

Electronic Theses and Dissertations

The main types of hypergolic propellants used at Kennedy Space Center (KSC) are hydrazine (HZ) and monomethylhydrazine (MMH). HZ and MMH are classified as hazardous materials and they are also known to be potentially carcinogenic to humans; therefore, handling these substances and their waste is strictly regulated. The wastes streams from HZ and MMH have been estimated to be the main hazardous wastes streams at KSC. Currently at KSC these wastes are first neutralized using citric acid and then they are transported on public roads for incineration as hazardous materials. A new method using alpha ketoglutaric acid (AKGA) was proposed …

Virtual Interactions With Real-Agents For Sustainable Natural Resource Management, Tyler Pierce

Electronic Theses and Dissertations

Common pool resource management systems are complex to manage due to the absence of a clear understanding of the effects of users’ behavioral characteristics. Non-cooperative decision making based on individual rationality (as opposed to group rationality) and a tendency to free ride due to lack of trust and information about other users’ behavior creates externalities and can lead to tragedy of the commons without intervention by a regulator. Nevertheless, even regulatory institutions often fail to sustain natural common pool resources in the absence of clear understanding of the responses of multiple heterogeneous decision makers to different regulation schemes. While modeling …

Study Of The Effect Of Surface Morphology On Mass Transfer And Fouling Behavior Of Reverse Osmosis And Nanofiltration Membrane Processes, Yuming Fang

Electronic Theses and Dissertations

Reverse osmosis (RO) and nanofiltration (NF) membranes are pressure driven, diffusion controlled process. The influence of surface characteristics on membrane process performance is considered significant and is not well understood. Current mass transport models generally assume constant mass transfer coefficients (MTCs) based on a homogeneous surface. This work evaluated mass transfer processes by incorporating surface morphology into a diffusion-based model assuming MTCs are dependent on the thickness variation of the membrane’s active layer. To mathematically create such a surface layer, Gaussian random vectors embedded in a software system (MATLAB) were used to generate a three-dimensional ridge and valley active layer …

Individual And Population Responses Of The Caribbean Sponge, Aplysina Cauliformis, To Natural And Anthropogenic Stressors, Cole Gregory Easson

Electronic Theses and Dissertations

Coral reefs are under increasing threat from a diversity of stressors. These reefs have undergone a phase shift from coral-dominated to algal-dominated ecosystems, and in many cases other functional groups such as sponges are now the predominant organisms on many reefs. This dissertation investigated the responses of a combranching sponge, Aplysina cauliformis, to algal contact, eutrophication, hurricanes, and disease. The effects of algal competition, anthropogenic nutrients and a combination of these stressors on A. cauliformis were examined using factorial designed field experiments on Bahamian reefs. These experiments demonstrated a complex interaction between sponge and alga, in which the green alga, …

Effects Of Temperament, Attachment, And Parental Sensitivity On The Development Of Adhd, Danielle C. Rubinic

Electronic Theses and Dissertations

Attention deficit/hyperactivity disorder (ADHD) is one of the most common and well-researched childhood disorders. Despite extensive knowledge, there remains a demand to understand ADHD from a developmental psychopathology perspective. Even more important than recognizing symptoms, it is necessary to determine how biological and environmental factors in a child's life play a role in the development of ADHD. In the proposed study, three significant factors were examined in relation to ADHD: attachment, temperament, and parental sensitivity with an emphasis on goodness of fit. Regression analyses were utilized to examine data from the Early Childhood Longitudinal Study, Birth Cohort (ECLS-B) to determine …

Evaluation Of Dna Barcoding As A Technique For Elucidating The Diet Of Louisiana Waterthrush Nestlings, Brian K. Trevelline

Electronic Theses and Dissertations

The Louisiana Waterthrush (Parkesia motacilla) (LOWA) is a Neotropical-Nearctic migrant songbird that annually breeds in the Eastern United States. As an obligate riparian species, it preys upon a diverse community of benthic macroinvertebrates along headwater streams. Fecal material potentially contains residual DNA that can be used to molecularly identify prey species. The objective of this study was to develop a non-invasive technique capable of elucidating the diet of Waterthrush nestlings from residual DNA present in fecal sacs via DNA barcoding. Our limited analysis revealed that the majority of the analyzed fecal sacs were comprised of an acid-sensitive family of Ephemerotperan …

Predictors Of Health Promoting Lifestyles In Baccalaureate Nursing Students, Faye J. Grund

Electronic Theses and Dissertations

Background: Nurses comprise the largest segment of healthcare professionals. As nursing students become health professionals, they will have a significant role in modeling health promoting lifestyles and educating patients regarding healthy lifestyle choices.

Purpose: The purpose of this study was to determine the predictors of health promoting lifestyles in baccalaureate nursing students.

Methods: A descriptive, cross-sectional design was used to determine associations between variables including gender, age, basic metabolic index (BMI), financial need, race, ethnicity, relationship status, living situation, general health status, self-reported depressive symptoms, social support, academic outcomes, self-efficacy, and heath promoting lifestyles. A convenience sample of participants from …

Potential Natural Product Phosphodiesterase Inhibitors, Michael John Cunningham

Electronic Theses and Dissertations

Three different studies set forth to investigate the role of phosphodiesterase (PDE) enzyme inhibitors in sexual dysfunction and mood regulation. First, naturalproducts were screened by computer modeling of PDE5A1. Second, compounds were isolated from a plant traditionally used as an aphrodisiac. Third, a new synthesis of psychoactive PDE4 inhibitor was attempted. An in silico screen was performed using chemical structures of isolated compounds thought to have some PDE inhibitory activity based on traditional use of the plants. A collection of compounds with structures similar to known natural product inhibitors was also included in the docking library. Glide docking software (Schrödinger) …

Trophic State Monitoring Of Lakes And Reservoirs Using Remote Sensing, Michelle Aten

Electronic Theses and Dissertations

Lakes and reservoirs are important resources that provide water for critical needs, such as drinking water, agriculture, recreation, fisheries, wildlife, and other uses. However, there is increasing concern that anthropogenic eutrophication threatens the usability of these natural resources. Therefore, this research investigates these complex hydrologic ecosystems and recommends a methodology for monitoring the trophic state of lakes and reservoirs using remote sensing data. The Mississippi Department of Environmental Quality provided in situ data for seven Mississippi lakes including, Arkabutla, Bay Springs, Enid, Grenada, Okatibbee, Ross Barnett, and Sardis lakes. This research explored the relationships between the Secchi depth (SD), chlorophyll-a …