Digital Commons Network^™

Aminooxy Reagents For Synthesis And Analysis : Expanding The Role Of Oximation., Sebastien Laulhe

Electronic Theses and Dissertations

The reaction between an aminooxy moiety (RONH2) and a carbonyl group of either an aldehyde or a ketone — known as an oximation reaction — is a versatile click chemistry coupling that generates a robust oxime ether linkage. The oximation reaction is chemoselective and can be performed under mild conditions in a large variety of solvents, including water. The attractive properties of the aminooxy group and derived oximation reactions, reviewed in Chapter 1, inspired us to use this chemistry as a key feature of our research. Specifically, we prepare functionalized aminooxy compounds so that the oximation chemistry can then serve …

Comparison Of Obesity Bias, Attitudes, And Beliefs Among Undergraduate Dietetic Students, Dietetic Interns, And Practicing Registered Dietitians, Sarah E. Welborn

Electronic Theses and Dissertations

The obesity epidemic in the United States is increasing, and health concerns are also on the rise as they are directly related to obesity. Even though the majority of Americans are overweight or obese, prejudice and weight bias continue to be prevalent and socially accepted in a culture that tolerates discrimination towards these individuals. Health care providers, including registered dietitians, are not exempt from instigating bias towards obese patients causing a decrease in the level of care that they receive. The main purpose of this study was to compare attitudes, beliefs, and bias concerning obesity among undergraduate dietetic students, dietetic …

Assessment Of Dietary Behaviors Of College Students Participating In The Health Promotion Program Bucs: Live Well, Courtney E. Mckinney

Electronic Theses and Dissertations

Rates of adult obesity in the United States continue to rise, especially among the college-age population who typically practice poor dietary choices, contributing to weight gain. College-age students experience a transitional phase called ‘emerging adulthood’ where they learn autonomy in many areas that influence long-term health status. The purpose of the online health promotion program BUCS: Live Well was to promote self-efficacy in ability to incorporate positive dietary changes, assess incidences of positive dietary habits after completing the program, and determine if weight status, residence, and health perceptions influence dietary behaviors. BUCS: Live Well was successful in assessing current dietary …

Detection Of Bacterial Retroelements Using Genomics, Sen Mu

Electronic Theses and Dissertations

The reverse flow of genetic information can occur when a special DNA polymerase called Reverse Transcriptase (RT) copies the genetic information in an RNA molecule back into a complementary DNA. One type of RT encoding gene found in bacteria is called a retron element. Recent bacterial genome sequencing projects have revealed many examples of retron RT genes. This gene assignment is based on comparison with a few known retron RT proteins. However, RT proteins are highly diverse in their amino acid sequences, and thus the assigned identity of these RT proteins as retrons in genome databases is questionable. One way …

Perceptions Of Alternative Center Students On Their Successes: A Case Study Of An Alternative Center In Northeast Tennessee, Julia E. Decker

Electronic Theses and Dissertations

This qualitative study examined how students at Science Hill High Alternative Center (AC) perceived their academic success. Eighteen alumni from Science Hill High School Alternative Center were interviewed to examine their perceptions of their success. Choosing 2 alumni to represent each of the 9 programs represented at the AC provided perceptions of 3 emerging themes: (a) relationships, (b) diversity of programs, and (c) personal growth. There were other findings that were noted but not identified as a theme. Other findings involved alumni wanting to reminisce about incidents that occurred and reflect on peers who were in attendance with them at …

Summer School: Perceptions Of Summer School Teachers In A Northeast Tennessee School District, Kari Arnold

Electronic Theses and Dissertations

The requirements of various educational reform movements such as No Child Left Behind and Race to the Top have left public education systems searching for ways to make sure students are reaching their highest potential. Because of the importance of accountability issues to school systems, it is important to examine ways to help students reach their potential. One tool school districts use to aid in improving student achievement is summer school. This qualitative study provides an overview of the history of summer school. Additionally, it offers a synopsis of various types of summer programs and populations often targeted by summer …

Very Cost Effective Partitions In Graphs, Inna Vasylieva

Electronic Theses and Dissertations

For a graph G=(V,E) and a set of vertices S, a vertex v in S is said to be very cost effective if it is adjacent to more vertices in V -S than in S.

A bipartition pi={S, V- S} is called very cost effective if both S and V- S are very cost effective sets. Not all graphs have a very cost effective bipartition, for example, the complete graphs of odd order do not. We consider several families of graphs G, including Cartesian products and cacti graphs, to determine whether G has a very cost effective bipartition.

Academic Achievement Of Elementary Students: A Comparison Study Of Student Athletes Versus Nonathletes, Kimberly R. Dyke

Electronic Theses and Dissertations

The place of sports in academic institutions has been analyzed at length for several years. However most studies focus on the participation of high school and university students in school sports. Very little research exists to suggest a positive or negative correlation between academic achievement and participation in interscholastic sports at the elementary level. As a result the relationship between academic performance and participation in school sports among elementary students in grades 4 and 5 was investigated in this study. Through an independent-samples t test analysis of 1,605 fourth and fifth grade boys and girls, it was determined that students …

Study Of Immobilizing Cadmium Selenide Quantum Dots In Selected Polymers For Application In Peroxyoxalate Chemiluminescence Flow Injection Analysis, Christopher S. Moore

Electronic Theses and Dissertations

Two batches of CdSe QDs with different sizes were synthesized for immobilizing in polyisoprene (PI), polymethylmethacrylate (PMMA), and low-density polyethylene (LDPE). The combinations of QDs and polymer substrates were evaluated for their analytical fit-for-use in applicable immunoassays. Hydrogen peroxide standards were injected into the flow injection analyzer (FIA) constructed to simulate enzyme-generated hydrogen peroxide reacting with bis-(2,4,6-trichlorophenyl) oxalate.

Linear correlations between hydrogen peroxide and chemilumenscent intensities yielded regression values greater than 0.9750 for hydrogen peroxide concentrations between 1.0 x 10^-4 M and 1.0 x 10^-1 M. The developed technique’s LOD was approximately 10 ppm. Variability of the prepared …

Preventing Skin Cancer In Adolescent Girls Through Intervention With Their Mothers, Mary K. Baker

Electronic Theses and Dissertations

Indoor tanning (IT) before the age of 35 increases one’s risk for melanoma by 75%, and epidemiological data show a 6.1% annual increase in the incidence of melanomas in white women younger than age 44 in the US. Population-based studies reveal that 15% of adolescents and 8% to 14% of their primary caregivers have engaged in IT in the past year.

The compelling case for IT being a significant risk factor for melanoma, together with the high rates of IT in teen girls and their mothers, provided a strong rationale for conducting an antitanning intervention directed at mother-daughter dyads. This …

Contextual Effects On Student Academic Achievement : A Multilevel Analysis., Shawnise Martin Miller

Electronic Theses and Dissertations

Approximately 1 million young people annually who should do not graduate from high school, positioning them on a downward trajectory of a lifetime of lower income and limited opportunities. The effects of low education ranges from micro-level consequences, such as unemployment and health, to mezzo-level consequences, such as neighborhood crime and poverty rates, to macro-level consequences, such as increased costs in government assistance and policy implications. Data from the 2011 American Community Survey (ACS) 5-Year Estimate dataset and from the Jefferson County Public School (JCPS) Division of Data Management, Planning, and Program Evaluation were used to examine environmental factors that …

Compound Identification Using Penalized Linear Regression., Ruiqi Liu

Electronic Theses and Dissertations

In this study, we propose a new method for compound identification using penalized linear regression. Compound identification is often achieved by matching the experimental mass spectra to the mass spectra stored in a reference library based on mass spectral similarity. In the context of the linear regression, the response variable is an experimental mass spectrum (i.e., query) and all the compounds in the reference library are the independent variables. However, the number of compounds in the reference library is much larger than the range of m/z values so that the data become high dimensional data with suffering from singularity. For …

The Nashville John School : Risk Deterrence And The Reintegrative Shaming Approach., Robin Malony Valenzuela

Electronic Theses and Dissertations

Contemporary anti-prostitution campaigns focus on curtailing “the demand” by punishing sexual service consumers. One component of this approach is a diversion program, or “john school,” offered to those who are caught buying prostitution. This ethnography focuses upon the Nashville John School (NJS), which consists of informational presentations that educate johns about the risks associated with prostitution. By employing a restorative justice approach, the NJS exemplifies elements of John Braithwaite’s “reintegrative shaming” theory (1989), which seeks to hold offenders accountable for their wrongdoing while avoiding stigmatization. This ethnographic study utilizes participant observation in the NJS, as well as individual interviews with …

The Women Of Battlestar Galactica And Their Roles : Then And Now., Jesseca Schlei Cox 1988-

Electronic Theses and Dissertations

This study used textual analysis to compare a science fiction television show from the 1970's to its remake in the 2000's concerning the representation of women in the shows and what that representation signifies about the United States' depiction of gender roles. Battlestar Galactica, its 1978 version and 2003 remake, was chosen. Coding sheets were utilized for each character for each episode of the show. Each coding sheet listed several themes such as toughness and gender stereotypes to be explored, and each character had a character profile based on the themes explored. It was predicted that the series would illustrate …

Genetic Mapping And Mechanism Of Action Of Rat Mammary Carcinoma Susceptibility Quantitative Trait Locus Mcs1b., Aaron D. Dendekker

Electronic Theses and Dissertations

Breast cancer is a complex disease that involves genetic, epigenetic, and environmental components. High and moderate penetrant genes have been identified that affect risk to developing breast cancer; however, these risk alleles are present in a small percentage of breast cancer cases. Low penetrant modifier genes have risk-associated alleles that are common in the population. Although these genes have lower penetrance, it is expected that the majority of genetic risk to developing breast cancer is controlled by common genetic variation. Studying mechanisms of common genetic variants on breast cancer risk is difficult due to their small individual effects and overlapping …

The Feeling Of Faith : A Thomistic Account Of Religious Emotions., John K. Dryden 1976-

Electronic Theses and Dissertations

This dissertation is a philosophical analysis of religious emotions. It draws upon Thomas Aquinas’s theory of the passions to build and apply a framework for thinking about religious emotions and their role in the spiritual life. The first two chapters are dedicated to building the theoretical framework. Chapter one outlines Aquinas’s theory of emotions in a very general way and compares this account to recent versions of cognitivism. By placing Aquinas in conversation with contemporary accounts, I show that his theory is able to capture the central insights of this mainstream philosophical view. According to the Thomistic account that emerges …

Genetic Characterization Of The K2 Serotype Capsule Of Klebsiella Pneumoniae Atcc 43816 And The Development Of A Bioluminescent Strain., Jacob Brandon Scott 1987-

Electronic Theses and Dissertations

OBJECTIVE: Klebsiella pneumoniae is a Gram-negative enterobacterium that is a major cause of community-acquired and nosocomial infections. We performed a genetic characterization of K. pneumoniae strain ATCC 43816, which is a well-studied strain with a K2 serotype capsular polysaccharide. To provide the ability to monitor bacteria within a host, we will develop a bioluminescence strain of K. pneumoniae by integrating the lux operon into the chromosome. METHODS: The ATCC 43816 capsule cluster sequencing was performed by closing gapE, in the Next Generation Sequencing by long range peR for template and primer walking. We constructed a bioluminescent K. pneumoniae by using …

Impedance Analysis Of Endothelial Cells Undergoing Orbital Shear Stress., Mark Jacob Gruenthal

Electronic Theses and Dissertations

Understanding the endothelium at the cellular level could further knowledge of the cardiovascular system as a whole and could therefore lead to advances in the prevention and treatment of cardiovascular disease. Electric cell-substrate impedance sensing is an in vitro technique that can be used for observing the behavior of endothelial cells in real-time using a fluid flow environment to simulate the circulatory system. This study examined the effect of fluid shear stress on human umbilical vein endothelial cells using electrochemical impedance spectroscopy (impedance sensing). Circuit models were fit to empirical data to measure cell layer resistance and capacitance changes, and …

Analysis Of The Blancan Procyonids Of Florida, Laura S. Gilmore

Electronic Theses and Dissertations

Procyonids are well known biologically but knowledge of their fossil record is comparatively sparse. This study seeks to describe a sample of late Blancan procyonid fossils composed mostly of postcranial and dental material. Fossils are analyzed using linear and 2D geometric morphometrics and compared with a large sample of modern specimens from a wide geographic area to understand the range of intraspecific variation. The large Procyon species is described as a new taxon based on morphology of the postcrania and lower dentition, while another Procyon species is also described as new due to an apomorphy in the upper dentition. A …

Language Arts Achievement Of Fourth Grade Students With Regard To Gender, Ethnicity, And Socioeconomic Status, Paula C. Davis

Electronic Theses and Dissertations

This study was conducted to see if a difference exists in the language arts proficiency levels of 2,080 fourth grade students with regard to gender, ethnicity, and socioeconomic status from 2010 through 2012 on the Tennessee Comprehensive Assessment Program. Specifically, this study considered the possibility that a difference existed in language arts proficiency levels between males and females.

A quantitative study was used to find differences in the language arts proficiency levels from 2010 through 2012 for males and females in the fourth grade in an upper East Tennessee urban school system. A quasi-experimental design was selected because preexisting data …

Biomodeling Of Pancreatic Tumor Mass., Justin Lee Howell

Electronic Theses and Dissertations

Pancreatic adenocarcinoma is the fourth leading cause of cancer death in the United States. It is identified by its rapid, invasive progression with a profound resistance to treatments such as chemotherapy. Unfortunately, there is a lack of information on how to effectively inhibit and control the rapid growth of pancreatic tumors, as well as limited information for diagnostics. With current methods, pancreatic cancer will continue to prevail as a leading cause of cancer death. We propose to study the complexity of pancreatic tumors with a systematic and analytical approach. Cancer is an abnormal growth of tissue caused by uncontrolled cell …

Modified Half-Edge Data Structure And Its Applications To 3d Mesh Generation For Complex Tube Networks., Richard Paris

Electronic Theses and Dissertations

In computer graphics 3D mesh generation is an important topic, it is required for a vast number of applications. While there are currently solutions available for the generation of meshes, there is not one that suits our application well that is written in C#, for this reason a C# implementation of the half-edge data structure as well as a C# implementation of the mesh generation algorithms is needed. This document will discuss in detail the method by which the algorithms are implemented, the improvements that are made on the half-edge data structure, and the new features that have been added …

Development Of Novel Layered Nanoparticles For More Efficient Cancer Treatment., Thomas A. Priest

Electronic Theses and Dissertations

Cancer is the second-most leading cause of death in the United States, with 1.66 million new cases expected to be diagnosed and over 580,000 Americans expected to die of cancer in 2013 alone. (American Cancer Society 2013) Current treatments result in damage to the healthy tissues and incomplete resections of solid tumors, but by harnessing nanotechnology, more effective treatments can be constructed. Gold nanoshells present a promising option for targeted cancer therapy. The anatomy of tumors causes the “enhanced permeability and retention” effect, which means that nano-scale particles will extravasate from the bloodstream and accumulate in the tumors. However, small …

Force Sensing Glove For Quantification Of Joint Torques During Stretching After Spinal Cord Injury In The Rat Model., Erik Seibt

Electronic Theses and Dissertations

An increasing amount of healthcare resources is used for the treatment and prevention of contractures in patients with spinal cord injury (SCI), with stretch and passive movements remaining the most prominent intervention methods. The results of both clinical trials and animal studies in recent years have shown traditional stretch therapies to be ineffective at preventing contracture and joint immobility, and have encouraged further emphasis on evidence-based practices. However, these studies only analyzed one aspect of stretching, dosage, and failed to look at the characteristic of joint torque. Recent clinical trials have unearthed the fact that the joint torque application of …

Academic Performance Of First-Year Students At A College Of Pharmacy In East Tennessee: Models For Prediction, Cheri W. Clavier

Electronic Theses and Dissertations

With the increase of students applying to pharmacy programs, it is imperative that admissions committees choose appropriate measures to analyze student readiness. The purpose of this research was to identify significant factors that predict the academic performance, defined as grade point average (GPA) at the end of the first professional year, of pharmacy students. The population consisted of 466 students enrolled in a Doctor of Pharmacy Program in northeast Tennessee over a 5-year period. Statistical procedures included bivariate correlations, t-tests for independent samples, and multiple regression. Analysis of the data revealed that the majority of the students in the population …

Peg Solitaire On Trees With Diameter Four, Clayton A. Walvoort

Electronic Theses and Dissertations

In a paper by Beeler and Hoilman, the traditional game of peg solitaire is generalized to graphs in the combinatorial sense. One of the important open problems in this paper was to classify solvable trees. In this thesis, we will give necessary and sufficient conditions for the solvability for all trees with diameter four. We also give the maximum number of pegs that can be left on such a graph under the restriction that we jump whenever possible.

A Mathematical Model For Antibiotic Resistance In A Hospital Setting With A Varying Population, Edward H. Snyder

Electronic Theses and Dissertations

Antibiotic-resistant bacteria(ARB) is causing increased health risk and cost to society. Mathematical models have been developed to study the transmission of resistant bacteria and the efficacy of preventive measures to slow its spread within a hospital setting. The majority of these models have assumed a constant total hospital population with the admission and discharge rates being equal throughout the duration. But a typical hospital population varies from day to day and season to season. In this thesis, we apply variable admission and discharge daily rates to existing deterministic and stochastic models which examine the transmission of single and dual resistant …

Genetic Imbalances In Endometriosis Detected By Oligonucleotide-Array Based Comparative Genomic Hybridization, Natalie Burke

Electronic Theses and Dissertations

Endometriosis is one of the most common gynecological diseases as it is thought to affect up to 15% of the female population. Characterized by the growth and proliferation of endometrial tissue outside of the uterine cavity, it is a complex condition with varying degrees of severity and can affect multiple regions of the body with symptoms ranging from a total lack of symptoms to debilitating pain and infertility. The most accepted theory of how endometriosis initiates is that of retrograde menstruation; however, approximately 90% of women with unobstructed fallopian tubes are thought to have some menstrual debris in the peritoneal …

Evaluation Of Colloidal Stability And Ecotoxicity Of Metal-Based Nanoparticles In The Aquatic And Terrestrial Systems, Lok R. Pokhrel

Electronic Theses and Dissertations

Intrinsic to the many nano-enabled products are atomic-size multifunctional engineered nanomaterials, which upon release contaminate the environments, raising considerable health and safety concerns. This Ph.D. dissertation is designed to investigate (i) whether metals or oxide nanoparticles are more toxic than ions, and if MetPLATE^TM bioassay is applicable as a rapid nanotoxicity screening tool; (ii) how variable water chemistry (dissolved organic carbon (DOC), pH, and hardness) and organic compounds (cysteine, humic acid, and trolox) modulate colloidal stability, ion release, and aquatic toxicity of silver nanoparticles (AgNP); and (iii) the developmental responses of crop plants exposed to Ag- or ZnO- (zinc …

Identifying Myotis Species Using Geometric Morphometrics And Its Implications For The Fossil Record And Conservation, Kyle J. Jansky

Electronic Theses and Dissertations

Dentaries of the 6 species of Myotis that occur in the eastern United States were analyzed using landmark-based geometric morphometrics. The species could be distinguished with a high degree of accuracy. Evidence was found of a phylogenetic signal in the morphology of the Neotropical and Nearctic Myotis sub-clades. There is also evidence of convergence in the morphology of the dentary among Myotis species that feed primarily by gleaning. When analyzed together there was no evidence of sexual dimorphism among the 6 eastern U.S. Myotis, but when analyzed individually some dimorphism may be present. A sample of fossil Myotis of …