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Recovery And Biogeography Of Pseudomonas And Burkholderia Species From The Human Home., Megan E. Purdy Aug 2013

Recovery And Biogeography Of Pseudomonas And Burkholderia Species From The Human Home., Megan E. Purdy

Electronic Theses and Dissertations

15 households in the Louisville Metro area were sampled, 7 had a patient with cystic fibrosis (CF), and 8 did not. Houses were sampled between 3 and 8 times each, and samples were collected from 123 different sites within and around the homes. These sites were categorized into the variable environment type based on ecological similarity of sites. Between 75 and 168 samples were collected from each home per visit. Recovery was examined for biogeographical patterns by environment type and season at multiple taxonomic levels. Approximately 10% of samples taken yielded Pseudomonas, and of these 61% were P. putida group, …

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Effects Of Telemetry Emg Implants On Hindlimb Locomotor Recovery In Thoracic Spinal Contused Rats., Matthew L. Hamilton Aug 2013

Effects Of Telemetry Emg Implants On Hindlimb Locomotor Recovery In Thoracic Spinal Contused Rats., Matthew L. Hamilton

Electronic Theses and Dissertations

Spontaneous recovery in rats after spinal cord injury (SCI), and interventions that improve or impede spontaneous recovery are not well understood. During a study to characterize recovery landmarks after SCI using telemetry EMG, we discovered loss of function in telemetry implanted animals. To investigate this difference further, we implanted animals with leads in various hindlimb muscles to look for behavioral and kinematic differences in recovery. We found significant differences in both open field locomotor testing (BBB) and kinematics between implant and non-implant groups where implanted groups showed loss of coordination, as well as trends for animals implanted below the knee …

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6-Phosphofructo-2-Kinase Inhibition Induces Autophagy As A Survival Mechanism., Alden Klarer Aug 2013

6-Phosphofructo-2-Kinase Inhibition Induces Autophagy As A Survival Mechanism., Alden Klarer

Electronic Theses and Dissertations

Altered metabolism has long been recognized as a defining characteristic of tumor cells. The increased glycolytic phenotype, an observation credited to Otto Warburg in 1956, is almost universal for cancer cells, making metabolic enzymes attractive targets for cancer therapy. However, anti-metabolic drugs, thus far, have not lived up to expectations as stand-alone agents to treat this disease. Unlike glycolytic enzymes that directly catabolize glucose to pyruvate, the family of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatases (PFKFBs) control the conversion of fructose-6-phosphate to and from fructose-2,6-bisphosphate, a key regulator of the glycolytic enzyme phosphofructokinase-1 (PFK-1). One isoform, PFKFB3, has been shown to be highly expressed by …

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Audiovisual Sensory Processing In Autism Spectrum Condition., Ryan Mikel Burdette Kiser Aug 2013

Audiovisual Sensory Processing In Autism Spectrum Condition., Ryan Mikel Burdette Kiser

Electronic Theses and Dissertations

Autism spectrum condition (ASC) consists of a set of pervasive developmental problems marked by measurable deficits in social interaction and communication, often coupled with specific and repetitive patterns of behavior. Featured restrictions in the capability to communicate and remain attentive can directly relate to the individual’s ability to interact with others within societal norms. Evidence has suggested that the deficits commonly demonstrated by individuals with autism may arise from a disconnect between neural processes governing sensory inputs. Comparing ASC subjects to controls, previous investigations had shown that electroencephalogram (EEG) recordings and event-related potentials (ERPs) evoked via separate auditory and visual …

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Novel Methods Based On Regression Techniques To Analyze Multistate Models And High-Dimensional Omics Data., Sutirtha Chakraborty Aug 2013

Novel Methods Based On Regression Techniques To Analyze Multistate Models And High-Dimensional Omics Data., Sutirtha Chakraborty

Electronic Theses and Dissertations

The dissertation is based on four distinct research projects that are loosely interconnected by the common link of a regression framework. Chapter 1 provides an introductory outline of the problems addressed in the projects along with a detailed review of the previous works that have been done on them and a brief discussion on our newly developed methodologies. Chapter 2 describes the first project that is concerned with the identification of hidden subject-specific sources of heterogeneity in gene expression profiling analyses and adjusting for them by a technique based on Partial Least Squares (PLS) regression, in order to ensure a …

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Computational Modelling Of Chemical Reactions Catalyzed By Cobalamin (B12)-Dependent Enzymes : Mechanistic Insights., Neeraj Kumar Aug 2013

Computational Modelling Of Chemical Reactions Catalyzed By Cobalamin (B12)-Dependent Enzymes : Mechanistic Insights., Neeraj Kumar

Electronic Theses and Dissertations

The biologically active derivatives of vitamin B12 (cobalamin) possess the only examples containing organometallic Co-C bonds in living systems where the cleavage of Co-C bond initiates the catalytic cycle of the enzymatic reactions. In this dissertation, the electronic structure of various intermediates and the mechanistic details of the methyl transfer reactions involved in the catalytic cycle of the methionine synthase (MetH) have been computationally investigated using hybrid quantum mechanics/molecular mechanics (QM/MM) simulations, density functional theory (DFT), and complete active space self-consistent field with second order perturbation theory (CASSCF/QDPT2) computational methodologies. QM/MM calculations in particular reveal that the cob(I)alamin intermediate is …

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Preclinical Safety Assessment Of Griffithsin-Based Vaginal Microbicides., Amanda Lasnik Aug 2013

Preclinical Safety Assessment Of Griffithsin-Based Vaginal Microbicides., Amanda Lasnik

Electronic Theses and Dissertations

Griffithsin (GRFT) is a protein derived from the red alga Griffithsia sp. off the coast of New Zealand. It binds and inactivates number of enveloped viruses including HIV-1. For a product to be developed as a microbicide, it must be safe and effective after repeated use. For initial in vivo safety testing we exposed mice repeatedly to various vaginal products and found that increased concentration of mouse serum albumin (MSA) in the vaginal lumen is predictive of epithelial damage. Repeated intravaginal administration of GRFT did not result in increased amounts of MSA, but the known epithelial disrupters nonoxynol-9 and benzylkonium …

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Mixture Of Poisson Distributions To Model Discrete Stock Price Changes., Rasitha Rangani Jayasekare Kodippuli Thanthillage Dona Aug 2013

Mixture Of Poisson Distributions To Model Discrete Stock Price Changes., Rasitha Rangani Jayasekare Kodippuli Thanthillage Dona

Electronic Theses and Dissertations

An application of a mixture of Poisson distributions is proposed to model the discrete changes in stock price based on the minimum price movement known as `tick-size'. The parameters are estimated using the Expectation-Maximization (EM) algorithm with a constant mixing probability as well as mixing probabilities which depend on order size. The model is evaluated using simulations and real data. Both the simulated and real data show reasonable estimates. Several adjustments are made to the model implementation to improve the efficiency with user written codes for the Newton Raphson algorithm and also implementing one of the most recent versions of …

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Cause And Impacts Of The Early Season Collapse Of Lilium Grayi (Gray’S Lily), On Roan Mountain, Tn/Nc, Russell J. Ingram Aug 2013

Cause And Impacts Of The Early Season Collapse Of Lilium Grayi (Gray’S Lily), On Roan Mountain, Tn/Nc, Russell J. Ingram

Electronic Theses and Dissertations

A population of the rare Southern Appalachian endemic species Lilium grayi, (Gray’s lily) Roan Mountain, TN/NC was monitored for 2 years to determine the cause and impact of an early season collapse. High concentrations of the Lilium spp. host-specific fungal phytopathogen, Pseudocercosporella inconspicua (G. Winter) U. Braun were associated with 19/20 symptomatic and 0/30 asymptomatic plants. Strength of the association between pathogen and disease and the replication of disease symptoms in 4/4 healthy hosts showed that P. inconspicua was the causal agent of the disease referred to as lily leaf spot. Disease had a severe impact on the population …

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Exploring The Potential Relationship Between Mindfulness And Ratings Of Perceived Exertion., Scott Michael Hanneman Aug 2013

Exploring The Potential Relationship Between Mindfulness And Ratings Of Perceived Exertion., Scott Michael Hanneman

Electronic Theses and Dissertations

This study focuses on an evolving, interdisciplinary area of research involving Exercise Science and Clinical Psychology. It investigated the relationship between the perception of present-moment exertion or effort during exercise and a concept called mindfulness. Exertion is commonly measured more objectively using physiological measures (e.g., heart rate) or more subjectively using self-rated Ratings of Perceived Exertion (RPE). Mindfulness is characterized as “present-moment, non-judgmental awareness,” or “living in the present.” Despite the acknowledged benefits of physical activity, many people find it burdensome, stressful, and emotionally taxing, especially when first starting an exercise program. Based upon previous research, it was hypothesized that …

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Modeling Risk For The Development Of Child Anxiety : The Role Of Parent Emotion Socialization Practices, Children's Emotional Competence, And Physiological Responsiveness., Sarah Ramsey Williams Aug 2013

Modeling Risk For The Development Of Child Anxiety : The Role Of Parent Emotion Socialization Practices, Children's Emotional Competence, And Physiological Responsiveness., Sarah Ramsey Williams

Electronic Theses and Dissertations

The prevalence of child anxiety is high and anxiety disorders are often left untreated throughout childhood and adolescence. Many studies have focused on the role of parenting in understanding the development of anxiety during childhood. Given the importance of the parent-child relationship in a child's development of emotional competence, the role of the parent in facilitating their child's emotional development was proposed here to provide a more specific method of assessing the impact of parenting on risk for developing anxiety. Specifically, the current study hypothesized that parent emotion socialization would predict child emotional development. Further, the study sought to build …

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Influence Of Lonicera Maackii On Leaf Litter Decomposition And Macroinvertebrate Communities In An Urban Stream., Catherine A. Fargen Aug 2013

Influence Of Lonicera Maackii On Leaf Litter Decomposition And Macroinvertebrate Communities In An Urban Stream., Catherine A. Fargen

Electronic Theses and Dissertations

Lonicera maackii (amur honeysuckle) is an aggressive alien shrub that invades many habitats in the Eastern United States, including along streambanks. This study investigated the direct and indirect effects of L. maackii invasion on leaf litter decomposition in an urban stream by placing leaf litter packs of L. maackii and the native Acer saccharum (sugar maple) in stream segments invaded by or managed for L. maackii. We found L. maackii litter decomposed two times faster than native A. saccharum, and A. saccharum leaf litter supported a higher abundance of macroinvertebrates than L. maackii. Functional feeding groups of macroinvertebrates were also …

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Characterization Of Promoter Regions Of Parotid Gland Genes., Sara M. Perez 1987- Aug 2013

Characterization Of Promoter Regions Of Parotid Gland Genes., Sara M. Perez 1987-

Electronic Theses and Dissertations

BACKGROUND: Salivary secretion aids in digestion, host defense, and lubrication. Parotid salivary gland defects from Sjogren’s Syndrome affect more than one million Americans and cause dry mouth leading to oral disease. The Amylase 1 gene and the PSP gene are markers of parotid gland differentiation and indicate normal parotid gland function. Transcriptional activators of genes involved in parotid differentiation have not been characterized. HYPOTHESIS: Characterizing transcriptional activating sites in gene promoter regions will confirm upstream activating factors in bioinformatic network pathways. METHODS: Two promoter regions of mouse amylase 1 were identified using the ECR Browser, PCR amplified and ligated into …

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Unpacking The Temperament Weight Relationship: The Mediating Role Of Food Preferences, Sarah A. Berry Aug 2013

Unpacking The Temperament Weight Relationship: The Mediating Role Of Food Preferences, Sarah A. Berry

Electronic Theses and Dissertations

The current study examined the mediating role of possible food preferences on the temperamentweight relationship among 18-month-old toddlers. Parents of 37 typically developing toddlers completed the Early Childhood Behavior Questionnaire (ECBQ). During a lab visit toddlers’ weight and recumbent length were measured and recorded. Toddlers also completed a sequential touching task to examine their ability to categorize a healthy group of foods and an unhealthy group of foods. The only temperament measure found to associate with both child weight status and food categorization was inhibitory control. Toddlers’ food categorization was not found to mediate the relationship between inhibitory control and …

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The Relationship Of Stress Levels To Wellness Practices Among U.S. Radiologic Technology Program Directors, Jesse D. Pennington Aug 2013

The Relationship Of Stress Levels To Wellness Practices Among U.S. Radiologic Technology Program Directors, Jesse D. Pennington

Electronic Theses and Dissertations

The purpose of this modified replication study is to examine the relationship between the stress levels and the wellness practices of U.S. radiologic technology program directors and to determine if correlations exist between wellness practices and stress levels of the group. Additionally, relaxation activities and the feelings, characteristics, and symptoms associated with stress were considered. The design of the study was ex post facto correlational. The population of the study was U.S. radiologic technology program directors working in JRCERT accredited programs. The electronic instrument was distributed to 635 program directors through e-mail, with 424 (66.7%) usable returns. Significant associations were …

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Evaluation Of Drug Release From Abraxane And Doxil In Tumor Tissue., Michael Christopher Clark Aug 2013

Evaluation Of Drug Release From Abraxane And Doxil In Tumor Tissue., Michael Christopher Clark

Electronic Theses and Dissertations

Currently, the clinical strategy to treat cancer consists of a combination of surgery, radiotherapy, and chemotherapy on the basis of clinical and molecular staging. Nanotechnology applied to biomedical sciences has paved the way for the development of novel strategies for early detection and more efficient treatment of diseases. Abraxane and Doxil are approved formulations that utilize nanoparticles carrying the drugs paclitaxel and doxorubicin, respectively; however, tumors are not completely eradicated in some patients. It is well known that inefficient vascularization may prevent optimal transport of oxygen, nutrients, and therapeutics to cells in solid tumors. In order to quantitatively evaluate therapy …

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Ventricular Assist Device And Extracellular Matrix Combination Therapy In A Chronic Ischemic Heart Failure Bovine Model., Erin F. Smith Aug 2013

Ventricular Assist Device And Extracellular Matrix Combination Therapy In A Chronic Ischemic Heart Failure Bovine Model., Erin F. Smith

Electronic Theses and Dissertations

Purpose: Currently, heart transplantation and mechanical circulatory support (MCS) are the preferred treatments for end stage heart failure. However, these therapies are associated with a shortage of donor organs, a 5-yr survival rate of 80%, and adverse events associated with long-term MCS usage. To overcome these limitations, new clinical paradigm is proposed using a combination therapy of MCS and extracellular matrix (ECM) injection therapy to promote myocardial recovery. Methods: The experimental design consisted of a control (no therapy, n=10) and 3 test groups: (1) ECM only (n=2); (2) MSC (HVAD) only (n=2); and (3) HVAD + ECM (n=2) in a …

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Behavioral Rhythm, Sleep, And Mood Disturbances In Newly Admitted Nursing Home Residents., Irene M. Kostiwa Aug 2013

Behavioral Rhythm, Sleep, And Mood Disturbances In Newly Admitted Nursing Home Residents., Irene M. Kostiwa

Electronic Theses and Dissertations

Older adults entering a nursing home face many physical and psychosocial challenges, all at a point in life when their bodies may be least equipped to handle such adversity. Data for the present study were collected for 186 incoming residents from 6 nursing homes over the course of 1 year. Fifty-six participants were interviewed at the earliest possible time point following admission and rest-activity data were collected via actigraphy for 1 week, after which participants were interviewed a second time. Newly admitted residents in this sample were functionally dependent, highly medicated, and diagnosed with many conditions associated with sleep and/or …

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Systemic Leptin Modulates The Expression Of E-Cadherin, Β-Catenin In The Ovary Of Dietary-Induced Obese Infertile Rats, Olufunke A. Sokan Aug 2013

Systemic Leptin Modulates The Expression Of E-Cadherin, Β-Catenin In The Ovary Of Dietary-Induced Obese Infertile Rats, Olufunke A. Sokan

Electronic Theses and Dissertations

One of the numerous complications of obesity is infertility. Leptin has been shown to reverse infertility; however, exact mechanism is poorly understood. Recent evidence indicates Ecadherin/ β-catenin complex, which is a structural constituent of adherens junction, is expressed in the rat ovary during folliculogenesis. We hypothesized that systemic leptin modulates the expression of E-cadherin and β-catenin in dietary-induced obese infertile rats to reverse infertility. Female Sprague-Dawley rats were fed either regular chow diet (RCD) (n=6) or high fat diet (HFD) (n=14). Oestrus cycles were monitored daily until their cycles became irregular. 100 ug/ml of leptin was given intraperitoneally to HFD-fed …

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A Glyptosaurine Lizard From The Eocene (Late Uintan) Of San Diego, California, And Implications For Glyptosaurine Evolution And Biogeography, David Moscato Aug 2013

A Glyptosaurine Lizard From The Eocene (Late Uintan) Of San Diego, California, And Implications For Glyptosaurine Evolution And Biogeography, David Moscato

Electronic Theses and Dissertations

Glyptosaurinae is an extinct subfamily of lizards of the family Anguidae. Glyptosaurine lizards are known exclusively from the Paleogene of North America and Eurasia, reaching their peak of diversity and distribution in the Eocene. In North America these lizards are largely restricted to the intermontane basins along the Rocky Mountain range, with only sparse, indeterminately-identified skeletal elements known from outside of this region. Glyptosaurine lizards are split into two tribes: the monophyletic Glyptosaurini and paraphyletic “Melanosaurini”. Within Glyptosaurini, the most common and widespread genus is Glyptosaurus. In this study I describe a new specimen assignable to G. sylvestris, …

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Teacher Evaluation And Classroom Practice: Teacher Perceptions In Northeast Tennessee, Christopher D. Bogart Aug 2013

Teacher Evaluation And Classroom Practice: Teacher Perceptions In Northeast Tennessee, Christopher D. Bogart

Electronic Theses and Dissertations

The purpose of this quantitative study was to investigate the perceptions of K-12 teachers as they relate to the implementation of the Tennessee Educator Acceleration (TEAM) evaluation framework. Survey links were sent to 1,115 K-12 teachers from 4 Northeast Tennessee school districts. The survey achieved a 24% return rate for a total of 270 participants. The research evaluated K-12 teachers’ overall perceptions of the TEAM evaluation framework, their perceptions of changes to their lesson planning processes, their perceptions of changes in the use of instructional strategies in their classrooms, and their perceptions of changes in the amount of time needed …

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Microsporidia Spore Adherence And Host Cell Infection In Vitro, Cory A. Leonard Aug 2013

Microsporidia Spore Adherence And Host Cell Infection In Vitro, Cory A. Leonard

Electronic Theses and Dissertations

Microsporidia infect invertebrate and vertebrate animals. Human pathogenic microsporidia are associated with severe disease in immunocompromised individuals, and mostly asymptomatic infection in the immunocompetent. Treatment options for microsporidiosis are limited, incompletely effective, and associated with toxicity. Furthermore, microsporidia infection of healthy individuals is poorly understood, and the consequences of asymptomatic infection have not been determined. Little is known about the molecular mechanisms of microsporidia infection, but such information is essential for the development of new therapies. Spores adhere to host cell surfaces in vitro. Our laboratory has focused on determining specific host cell and microsporidia spore surface participants in spore …

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The Eiios Task: Executive Function And Word Learning At 18-Months, Leslie A. Patton Aug 2013

The Eiios Task: Executive Function And Word Learning At 18-Months, Leslie A. Patton

Electronic Theses and Dissertations

This study was an investigation of the association between executive functioning (EF) ability and language development in the latter half of the second year. Fifty-five typically developing 18- month-olds were brought into the lab. The elicited imitation with inappropriate object substitution (EIIOS) task was used as a developmentally sensitive measure of EF. Language acquisition was assessed using a real-time word learning task as well as a parent report measure of vocabulary size (MacArthur-Bates Communicative Development Inventory: Words and Sentences Version). Contrary to expectations, very few statistically significant associations were found between the EF measure and either language measure. Despite these …

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Bioengineering The Expression Of Active Recombinant Human Cathepsin G, Enteropeptidase, Neutrophil Elastase, And C-Reactive Protein In Yeast, Eliot T. Smith Aug 2013

Bioengineering The Expression Of Active Recombinant Human Cathepsin G, Enteropeptidase, Neutrophil Elastase, And C-Reactive Protein In Yeast, Eliot T. Smith

Electronic Theses and Dissertations

The yeasts Pichia pastoris and Kluyveromyces lactis were used to express several recombinant human proteins for further biochemical characterization. Two substitution variants of recombinant human enteropeptidase light chain (rhEPL) were engineered to modify the extended substrate specificity of this serine protease. Both were secreted as active enzymes in excess of 1.7 mg/L in P. pastoris fermentation broth. The substitution variant rhEPL R96Q showed significantly reduced specificities for the preferred substrate sequences DDDDK and DDDDR; however, the rhEPL Y174R variant displayed improved specificities for these substrate sequences relative to all other reported variants of this enzyme. The neutrophil serine proteases human …

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Systematics, Climate, And Ecology Of Fossil And Extant Nyssa (Nyssaceae, Cornales) And Implications Of Nyssa Grayensis Sp. Nov. From The Gray Fossil Site, Northeast Tennessee, Nathan R. Noll Aug 2013

Systematics, Climate, And Ecology Of Fossil And Extant Nyssa (Nyssaceae, Cornales) And Implications Of Nyssa Grayensis Sp. Nov. From The Gray Fossil Site, Northeast Tennessee, Nathan R. Noll

Electronic Theses and Dissertations

The Late Hemphillian (latest Miocene or earliest Pliocene, 7-4.5 Ma) Gray Fossil Site in northeastern Tennessee is interpreted to represent a lacustrine paleokarst fed by a river or stream. This research focuses on the morphological and systematic relations of Nyssa endocarps (fruit pits) from the fossil site to extinct and extant Nyssa species. A combination of metric and nonmetric traits allows recognition of a new species: Nyssa grayensis sp. nov. This fossil species shares the most similarities with the extant Nyssa ogeche Bartram ex Marshall from southeast North America and the Eocene fossil Nyssa eolignitica Berry from western Tennessee. Affinities …

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A Content Analysis Of A&E'S Hoarders, Samantha J. Redwine Aug 2013

A Content Analysis Of A&E'S Hoarders, Samantha J. Redwine

Electronic Theses and Dissertations

The interest in hoarding has peaked since its first clinical definition in 1996 and is evident by six television shows centered on the topic. This thesis reports the results a content analysis of two seasons (21 episodes) of the popular T.V. series A&E’s Hoarders. People rationalize hoarding in ways that both differ and overlap. Doctors, professional organizers, hoarders and their loved ones collectively frame hoarding as a medical and mental health problem. The results suggest that Americans’ perceptions of hoarding behavior has shifted from one that is deviant behavior to one that is medicalized.

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“The Price Of A Woolworth’S Burger:” The Importance And Overshadowing Of The Nashville Sit-Ins, Aaron M. Owens Aug 2013

“The Price Of A Woolworth’S Burger:” The Importance And Overshadowing Of The Nashville Sit-Ins, Aaron M. Owens

Electronic Theses and Dissertations

This thesis examines the sit-in demonstrations that used direct action and civil disobedience to target segregation at store lunch counters. The Nashville demonstrations were the last sit-in protests to occur that are discussed in this thesis, which also examines the protests in Wichita and Greensboro. Historians argue that the Wichita and Greensboro sit-ins were the most important demonstrations of their kind. The movement in Wichita was the first protest to end segregation policies at targeted stores, and the Greensboro protests led to a direct action movement in over fifty other cities targeting lunch counters. However, the Nashville based sit-ins surpassed …

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Regulating Rsma Expression In Pseudomonas Aeruginosa, Sean D. Stacey Aug 2013

Regulating Rsma Expression In Pseudomonas Aeruginosa, Sean D. Stacey

Electronic Theses and Dissertations

Pseudomonas aeruginosa, a Gram-negative bacillus, commonly infects immunocompromised individuals and uses a variety of virulence factors to persist in these hosts. The posttranscriptional regulator, RsmA, plays a role in the expression of many virulence factors in P. aeruginosa. RsmA up regulates virulence factors used in colonizing hosts. However, regulation of rsmA is not well elucidated. Transposon mutagenesis was performed on P. aeruginosa containing a transcriptional rsmA-lacZ fusion to answer this question. Mutants were screened via β-galactosidase assay and transposon insertions identified via arbitrary PCR. A probable MFS transporter, we named mtpX, was one significant transposon mutant identified. …

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Synthesis Of Ester Derivatives Of Resveratrol As Potential Anti-Cancer Drugs, Parasmani Pageni Aug 2013

Synthesis Of Ester Derivatives Of Resveratrol As Potential Anti-Cancer Drugs, Parasmani Pageni

Electronic Theses and Dissertations

Resveratrol is a naturally occurring phytoalexin of the stilbene family produced by various plants in response to stress, UV radiation, and fungal attack. It is primarily found in peanuts, berries, grape skin, and red wine. Resveratrol has been found to exhibit anti-cancer, anti-inflammatory, anti-aging, and anti-oxidant properties. Research indicates that diets enriched with resveratrol containing substances result in less incidence of cancer. Unfortunately, the low bioavailability and solubility has been a huge setback for its potential prospects. As a result, efforts have been made to synthesize derivatives of resveratrol with increased solubility and bioavailability. Three triester novel resveratrol derivatives 3, …

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Novel Roles Of Replication Protein A Phosphorylation In Cellular Response To Dna Damage, Moises A. Serrano Aug 2013

Novel Roles Of Replication Protein A Phosphorylation In Cellular Response To Dna Damage, Moises A. Serrano

Electronic Theses and Dissertations

Human replication protein A (RPA) is an eukaryotic single-stranded DNA binding protein directly involved in a variety of DNA metabolic pathways including replication, recombination, DNA damage checkpoints and signaling, as well as all DNA repair pathways. This project presents 2 novel roles of RPA in the cellular response to DNA damage. The first elucidates the regulation of RPA and p53 interaction by DNA-dependent protein kinase (DNA-PK), ataxia telangiectasia mutated (ATM) and ATM- and Rad3-related (ATR) in homologous recombination (HR). HR and nonhomologous end joining (NHEJ) are 2 distinct DNA double-stranded break (DSB) repair pathways. Here, we report that DNA-PK, the …

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