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The Effect Of Road Crossings On Stream-Associated Salamanders Within Holly Springs National Forest, Caleb Ashton Aldridge
The Effect Of Road Crossings On Stream-Associated Salamanders Within Holly Springs National Forest, Caleb Ashton Aldridge
Electronic Theses and Dissertations
Road crossings have significant effects on wildlife, but there is limited information on how road crossings affect stream-associated salamanders. Stream-associated salamanders are vital to their ecological communities and are likely to experience the effect of roads more readily than other species due to their physiological characteristics. To test the effects of road crossings on stream-associated salamanders, I surveyed 12 pairs of confluent streams – one stream crossed by a road and the other not in each pair – within Holly Springs National Forest, Mississippi. Surveys in the summer of 2015 were used to measure abundance and species richness of stream-associated …
The Challenge Of Enhancement & Adaptability In Healthcare: An Ethical Framework For Organizations, Gary Edwards
The Challenge Of Enhancement & Adaptability In Healthcare: An Ethical Framework For Organizations, Gary Edwards
Electronic Theses and Dissertations
This work defends enhancements that aim at promoting adaptability and formulates a framework for how healthcare organizations can cope with these sorts of enhancements. It begins by defending explicit approaches to defining enhancements and sketches a tripartite conception of enhancements dependent on well-being, social, and perception approaches. After assessing several major arguments for and against enhancement, it defends an adaptability justification for enhancements. In light of this justification, the remaining sections explore the adaptability argument’s implications for healthcare, justify an organizational approach for dealing with these implications, and finally formulate an organizational ethics framework for coping with the adaptability argument’s …
Reassessing Survival, Movement, Resource Selection, And Sightability Of Pronghorn In Western South Dakota, Adam Kauth
Reassessing Survival, Movement, Resource Selection, And Sightability Of Pronghorn In Western South Dakota, Adam Kauth
Electronic Theses and Dissertations
Limited information exists on the survival, movements, resource selection, and densities of pronghorn (Antilocapra americana) inhabiting sagebrush-steppe regions within the Dakotas. Primary objectives of this study were to develop a sightability model for aerial surveying and to document survival rates and movement patterns for pronghorn in western South Dakota. Secondary objectives were to estimate seasonal home ranges, daily movements, determine cause-specific mortality, and evaluate summer and winter resource use and selection. Additionally, we evaluated exposure of pronghorn to novel diseases including Epizootic Hemorrhagic Disease (EHD), West Nile Virus (WNV), Blue Tongue Virus (BTV), Bovine Viral Diarrhea Virus (BVDV), Neospora, and …
Evaluation Of A Bioprocessed Soybean Meal On Nursery Pig Immune Status And Disease Resistance, Jacob R. Koepke
Evaluation Of A Bioprocessed Soybean Meal On Nursery Pig Immune Status And Disease Resistance, Jacob R. Koepke
Electronic Theses and Dissertations
Weaning is a stressful time in a piglet’s life that can have negative impacts on performance and health if not managed properly. The objective of this research was to evaluate the effects of a bioprocessed SBM alone or in combination with spray-dried plasma (SDP) or fishmeal (FM) on immune response at weaning with no imminent disease threat and during a porcine reproductive and respiratory virus (PRRSV) challenge. In the first trial, 239 pigs (initial BW 6.56 ± 0.87 kg, 21 d of age) were used in a 35-d study and allotted to one of 4 dietary treatments (10 pens/trt) according …
Identification Of Cdks As Novel Targets Of Aspirin And Its Metabolites: A Potential Role In Cancer Prevention, Rakesh Dachineni
Identification Of Cdks As Novel Targets Of Aspirin And Its Metabolites: A Potential Role In Cancer Prevention, Rakesh Dachineni
Electronic Theses and Dissertations
Background:
The pursuit of drugs that inhibit cyclin-dependent kinases (CDKs) has been an intense area of research for more than 15 years. Till date, although multiple CDK inhibitors have been identified and few are undergoing clinical trials, only two synthetic drugs have been approved by Food and Drug Administration (FDA) for use in the treatment of cancer. These two drugs are mainly used for the treatment of metastatic breast cancer in combination with other drugs; however they have toxicity associated with their use and extends patients life not more than 24 months. Therefore, there is an urgent need for …
Self-Assembled Architecture Of Natural Organic Matter, Cynthia Johnson-Edler
Self-Assembled Architecture Of Natural Organic Matter, Cynthia Johnson-Edler
Electronic Theses and Dissertations
This investigation focuses on the determination of the architecture of the natural organic matter (NOM) contained within a soft coal-like material, an agricultural soil and a peat material. NOM has been extracted from bulk materials, fractionated, reassembled, then characterized by 13C Solid State NMR, Pulsed-Field Gradient NMR (PFG-NMR), and Small Angle Neutron Scattering (SANS). Interpretation of the data obtained by SANS has established that the majority of the components of NOM are mass fractals in solution and surface fractals in the solid state. Surface-to-volume ratios calculated with PFGNMR data indicate the NOM components studied have varying disk-like shapes. These …
Food Protein-Based Core-Shell Nanocarriers For Oral Drug Delivery Applications: (Influence Of Shell Composition On In Vitro And In Vivo Functional Performance Of Zein Nanocarriers, Md Saiful Islam
Electronic Theses and Dissertations
Oral delivery is the most preferred route for drug administration. Oral drug delivery is limited by poor physicochemical properties of drugs and physiological barriers in the gastrointestinal tract. To this end, there is a need for developing new carrier systems to enhance the oral bioavailability of poorly absorbed molecules. Food-grade biopolymers are attractive materials for developing drug delivery carriers’ due to their unique properties and proven safety. Six different core-shell nanocarriers were prepared using food-grade biopolymers including zein-casein (ZC) nanoparticles, zein-lactoferrin (ZLF) nanoparticles, zein-β-lactoglobulin (ZLG) nanoparticles, zein-whey protein isolate (ZWP) nanoparticles, zein-pluronic-lecithin (ZPL) nanoparticles and zein-PEG (ZPEG) micelles. The study …
Swift Foxes In Southwestern South Dakota: Assessing The Current Status Of A Reintroduced Population, Sarah Ann Nevison
Swift Foxes In Southwestern South Dakota: Assessing The Current Status Of A Reintroduced Population, Sarah Ann Nevison
Electronic Theses and Dissertations
Swift foxes (Vulpes velox) were reintroduced into Badlands National Park between 2003 and 2006 after being nearly extirpated from South Dakota in the early 1900’s. Genetic analysis provided strong evidence that the reintroduction was successful, but viability analysis indicated the population may be in jeopardy with a high probability of extinction. Recently, the population has declined due to various biotic and abiotic factors (e.g., recent weather patterns, effects of plague [Yersinia pestis], and increased coyote [Canis latrans] numbers). No information on the status of swift foxes has been collected since 2009. Between 2014 and 2016, the objectives of this study …
Growth Potential And Genetic Diversity Of Yellow Perch In South Dakota, Alex J. Rosburg
Growth Potential And Genetic Diversity Of Yellow Perch In South Dakota, Alex J. Rosburg
Electronic Theses and Dissertations
Yellow Perch Perca flavescens represent a valued sport fish throughout their range and are an important prey species for piscivorous fishes. In South Dakota, two distinct population types of Yellow Perch have been characterized that differ in growth, survival, and recruitment patterns. Fast growth populations exhibit high growth rates, high mortality, low population density, and inconsistent recruitment. In contrast, slow growth populations are characterized by reduced growth rates, low mortality, high population density, and relatively consistent recruitment. The role of genetics in contributing to these population characteristics is currently unknown. To address these questions, I used high-throughput restriction-site associated DNA …
Genetic Interference And Receptor Biology Of Neglected Influenza Viruses, Runxia Liu
Genetic Interference And Receptor Biology Of Neglected Influenza Viruses, Runxia Liu
Electronic Theses and Dissertations
Influenza B virus (IBV) is an important pathogen that infects humans and causes seasonal influenza epidemics. By using next-generation sequencing (NGS) approach, we analyzed total mRNAs extracted from A549 cells infected with B/Brisbane/60/2008, and identified four defective genomes in IBV with two from the polymerase basic subunit 1 (PB1) segment and the other two from the matrix (M) segment. Each of them can potently inhibit the replication of IBV. One derived from PB1 segment was able to interfere modestly with influenza A virus (IAV) replication. The productions of the four defective RNAs are not dependent on the cell types. The …
Genetic Algorithm For University Course Timetabling Problem, Achini Kumari Herath
Genetic Algorithm For University Course Timetabling Problem, Achini Kumari Herath
Electronic Theses and Dissertations
Creating timetables for institutes which deal with transport, sport, workforce, courses, examination schedules, and healthcare scheduling is a complex problem. It is difficult and time consuming to solve due to many constraints. Depending on whether the constraints are essential or desirable they are categorized as ‘hard’ and ‘soft’, respectively. Two types of timetables, namely, course and examination are designed for academic institutes. A feasible course timetable could be described as a plan for the movement of students and staff from one classroom to another, without conflicts. Being an NP-complete problem, many attempts have been made using varying computational methods to …
Regulation Of The Kras Promoter In Pancreatic Cancer By Proteins And Small Molecules, Harshul Batra
Regulation Of The Kras Promoter In Pancreatic Cancer By Proteins And Small Molecules, Harshul Batra
Electronic Theses and Dissertations
DNA-binding proteins play a pivotal role in cell biology. The major class of DNA-binding proteins are transcription factors (TFs). TFs are central to almost every fundamental cellular process such as cell development, differentiation, cell growth, and gene expression. They account for 10% of the genes in eukaryotes. In mammals, more than 700 TFs are identified to be DNA-binding TFs. They bind to the TF binding sites (TFBSs) in the genome and regulate the expression of their target genes. kRAS is a proto-oncogene with intrinsic GTPase activity, that contributes to cell proliferation, division, and apoptosis. kRAS mutations are observed in >95% …
Development Of Phenotypic Drug Discovery Models For Tropical Parasitic Diseases, Surendra Kumar Jain
Development Of Phenotypic Drug Discovery Models For Tropical Parasitic Diseases, Surendra Kumar Jain
Electronic Theses and Dissertations
Malaria and visceral leishmaniasis are major killer parasitic diseases. These diseases though occur primarily in tropical countries; economic burden and overall health impacts of malaria and leishmaniasis are global. The emergence of drug-resistant and more-virulent strains of the pathogens has further amplified the problems. New drug discovery approaches primarily rely on in vitro and in vivo models of the disease. The pathogens causing leishmaniasis and malaria are intracellular. Leishmania parasite grows as amastigotes in macrophages cells, and malaria parasite grows within the hepatocytes or erythrocytes. The intracellular forms of the pathogens are responsible for the pathophysiology of the diseases. New …
Characterizing The Developmental And Reproductive Toxicities Of Cannabidiol And Δ9-Tetrahydrocannabinol, Dennis Ray Carty
Characterizing The Developmental And Reproductive Toxicities Of Cannabidiol And Δ9-Tetrahydrocannabinol, Dennis Ray Carty
Electronic Theses and Dissertations
Medical marijuana is legal in twenty-nine of the United States and an additional nineteen states have passed legislation for cannabidiol (CBD) treatment of drug-resistant epilepsy, such as Dravet Syndrome (DS) which is diagnosed in children as young as two months. While CBD has shown anecdotal and recently clinical trial efficacy in reducing seizure frequency in DS patients, little is known about the potential adverse side-effects on child physiology, brain development, adult disease, or subsequent generations. Moreover, CBD is rarely administered without including low concentrations of Δ9-tetrahydrocannabinol (THC). The goal of this project is to characterize the relative morphological, behavioral, reproductive, …
Phytochemical Investigation Of Psychoactive Medicinal Plants For The Treatment Of Neurological Disorders, Vedanjali Gogineni
Phytochemical Investigation Of Psychoactive Medicinal Plants For The Treatment Of Neurological Disorders, Vedanjali Gogineni
Electronic Theses and Dissertations
Neurological disorders include disorders such as migraine, tension-type headaches, Parkinson’s disease (PD), epilepsy, dementia, and Alzheimer’s disease (AD). Globally, PD is the second most comneurodegenerative disorder following AD. In developed countries, PD affects 1% of all population over 60 years of age. The prevalence of PD is increasing over the years and is expected to double by 2030. It is proposed that combination of dopaminergic drugs with monoamine oxidase B (MAO-B) inhibitors, anticholinergics, catechol-O-methyl transferase inhibitors, and other non-dopaminergic drugs can better alleviate levodopa-induced motor complications along with better control of motor symptoms. MAO-B inhibitors play a significant role in …
Dose-Response Association Between Acute Exercise Duration, Exercise Recovery And Cognitive Function, Elizabeth Ann Crush
Dose-Response Association Between Acute Exercise Duration, Exercise Recovery And Cognitive Function, Elizabeth Ann Crush
Electronic Theses and Dissertations
Previous studies have shown moderate intensity exercise to be a desired intensity level to optimize cognitive function, however, this research has mostly been conducted among older adults despite the claim that cognitive function may start to decline in the early years (i.e., 20s). Another research gap within this population is our limited understanding of the effects of different exercise durations and recovery periods on cognitive function. Thus, the purpose of this study was to examine the effects of different exercise durations and recovery periods on cognition using a treadmill-based protocol. In a counterbalanced, cross-over randomized controlled design, 352 participants, ages …
Comparing The Effects Of Cognitive And Social Stress Among Individuals With Headache, Yelena Louise Johnson
Comparing The Effects Of Cognitive And Social Stress Among Individuals With Headache, Yelena Louise Johnson
Electronic Theses and Dissertations
Stress is the most frequently reported trigger of headache. A number of studies have examined responses to cognitive and physical stressors among individuals with headache, primarily using self-report and various physiological measurements as outcome variables. In the stress literature more broadly, the Trier Social Stress Test (TSST) consistently has been shown to be a valid and reliable method of eliciting laboratory stress. However, this popular stress manipulation has not been previously used or promoted within the headache literature. The present study aimed to introduce the TSST to the headache literature and to experimentally compare the TSST to a cognitive stressor …
System Identification Of A Circulation Control Unmanned Aerial Vehicle, Mohammed Agha
System Identification Of A Circulation Control Unmanned Aerial Vehicle, Mohammed Agha
Electronic Theses and Dissertations
The advancement in automation and sensory systems in recent years has led to an increase the demand of UAV missions. Due to this increase in demand, the research community has gained interest in investigating UAV performance enhancing systems. Circulation Control (CC), which is an active control flow method used to enhance UAV lift, is a performance enhancing system currently studied. In prior research, experimental studies have shown that Circulation Control wings (CCW) implemented on class-I UAVs can reduce take-off distance by 54%. Wind tunnel tests reveal that CC improves aircraft payload capabilities through lift enhancement. Increasing aircraft payload capabilities causes …
The Relationship Between Participation In Tutoring And Accountability Outcomes In Three Urban Middle Schools, Pamela Rajadhyax
The Relationship Between Participation In Tutoring And Accountability Outcomes In Three Urban Middle Schools, Pamela Rajadhyax
Electronic Theses and Dissertations
This quantitative study was conducted to determine the relationship between participation in a school based tutoring and change in accountability measures on the Florida Standards Assessment (FSA) in Mathematics and English Language Arts (ELA) in the 2014-2015 and 2015-2016 school years. The research was designed to determine the impact of participation in tutoring for urban middle school students. All students who attended one of the three urban middle schools and participated in the administration of FSA for mathematics or ELA in both the 2014-2015 and 2015-2016 school years were divided into two groups: students who participated in school based tutoring …
Synthesis, Chemistry, Biological Evaluation And Structure-Activity Relationships Of Rac- And Chiral 6-Desmethyl-5Β –Hydroxy-D-Secoartemisinin And Analogs, Mohamed Elsideiq Jihan
Synthesis, Chemistry, Biological Evaluation And Structure-Activity Relationships Of Rac- And Chiral 6-Desmethyl-5Β –Hydroxy-D-Secoartemisinin And Analogs, Mohamed Elsideiq Jihan
Electronic Theses and Dissertations
The prevention and cure of malaria is difficult as it thrives under poor socio- and pharmacoeconomic conditions in third world, tropical and subtropical regions. It is a parasitic disease spread through the bite of an infected Anopheles mosquito. In humans, malaria can be caused by several Plasmodium species that include: Plasmodium falciparum, Plasmodium vivax, Plasmodium ovale, Plasmodium malariae and Plasmodium knowlesi. The natural product artemisinin is a sesquiterpene lactone with an endoperoxide bridge isolated from the Chinese annual herb qinghao (Artemisia annua L or sweet wormwood). The relatively stable endoperoxide bridge is essential for their antimalarial activity. The synthesis of …
G-Quadruplexes As Molecular Targets For Transcriptional Control, Rhianna Kyelle Morgan
G-Quadruplexes As Molecular Targets For Transcriptional Control, Rhianna Kyelle Morgan
Electronic Theses and Dissertations
DNA G-quadruplexes (G4s) have gained interest in modern drug discovery efforts. The majority of G4 research, including the mass of this research, heavily focuses on cancer therapeutic development, as G4s are more pronounced in oncogenic promoters compared to the rest of the genome, our efforts extend towards neuroprotection as well. In particular, this work covers G4s in the promoters of MYC, VEGF, kRAS, and Bcl-2. MYC and VEGF harbor the two most well described promoter G4s to date, and their stabilization cultivates transcriptional silencing. Downregulation of MYC reduces cell growth and alters cell energetics; it is promising for a variety …
Lipid Based Frameworks And Topical Ocular Inserts For The Delivery Of Small Molecule Therapeutics To The Posterior Segment Of The Eye, Sai Prachetan Balguri
Lipid Based Frameworks And Topical Ocular Inserts For The Delivery Of Small Molecule Therapeutics To The Posterior Segment Of The Eye, Sai Prachetan Balguri
Electronic Theses and Dissertations
Lipid based systems and topical ocular inserts of various drugs were developed for the intervention/treatment of posterior segment ocular complications. Indomethacin (IN) was developed into solid lipid nanoparticles (SLNs) and Nanostructured lipid carriers (NLCs). Effect of surface functionalization using chitosan (CS) on lipid nanocarriers was tested to evaluate corneal penetration. Surface modification of SLNs with CS increased ocular penetration of IN. NLCs maintained significantly higher IN concentrations in all ocular tissues tested, compared to the other formulations evaluated in vivo. Effect of surface poly (ethylene) glycol (PEG) functionalization of the NLCs on ocular disposition was studied using Ciprofloxacin (CIP) as …
Predictors Of Medication Nonadherence In Children/Adolescents With Attention Deficit Hyperactivity Disorder (Adhd) In Mississippi Medicaid Program, Wahidullah Noori
Predictors Of Medication Nonadherence In Children/Adolescents With Attention Deficit Hyperactivity Disorder (Adhd) In Mississippi Medicaid Program, Wahidullah Noori
Electronic Theses and Dissertations
Objectives: To examine adherence to ADHD stimulant medications and determined the condition-related, therapy-related, patient-related, health-system related, and social and economic related predictors of medication nonadherence in children/adolescents (4 – 18 years) with ADHD enrolled in Mississippi Medicaid Program. Methods: This was a retrospective cohort study of the Mississippi Medicaid administrative claims data. Data was analyzed from March 01, 2014 to February 29, 2016. Adherence was calculated as the proportion of days covered (PDC). PDC was calculated including and excluding summer break (June – August) and at two different timelines, at 6 months and 12 months depending upon the length of …
Stereotypes And The Self-Perceptions Of Black Women: How Places And Identity Strategies Matter, Brieann Avery
Stereotypes And The Self-Perceptions Of Black Women: How Places And Identity Strategies Matter, Brieann Avery
Electronic Theses and Dissertations
Black women are one of the most oppressed groups in America because they possess two qualities of being a minority in terms of race and gender. Whether it is magazines, television shows, or music videos, controlling images are established in the preservation of hegemonic power and to condone the remaining marginalization of black women. Black women are seen mostly sexually exploited in hip-hop. Black women are continuously being oppressed through hip-hop’s constructions created to reinforce ideals about race and gender positioning and inferiority in a hegemonic masculine world, Hip-hop promotes negative images of black women as sexual objects and the …
Evidence Of Chemical Camouflage In Pirate Perch (Aphredoderus Sayanus); Avoiding Detection By Colonizing/Ovipositing Prey Through Chemical Crypsis, Tyler Breech
Electronic Theses and Dissertations
No abstract provided.
Carbon Cycle Trends Recorded By Organic Carbon Stable Isotopes In Paleocene Strata, Benton County, Mississippi: Implications For Chronostratigraphy Of The Porters Creek And Naheola Formations, Erica Gerweck
Electronic Theses and Dissertations
The paleocene-eocene thermal maximum (petm) is one of the most studied carbon isotope excursions in earth's history. The petm occurred 55 million years ago when excess isotopically heavy carbon (c13) was added into earth's carbon cycle, resulting in ecological and environmental changes. The petm is marked by a negative stable carbon isotope excursion (cie) in marine and continental strata around the globe. The paleocene and eocene boundary is contained in the sedimentary fill of the Mississippi embayment so there is high potential to produce new petm stable isotope datasets. The purpose of this project is to analyze the boundary for …
The Frequency Of The Twelve Verb Tenses In History Papers Written By University Native Writers, Bushra Qahtani
The Frequency Of The Twelve Verb Tenses In History Papers Written By University Native Writers, Bushra Qahtani
Electronic Theses and Dissertations
Due to the variety and complexity of verb tenses in English, English as a Second Language (ESL) / English as a Foreign Language (EFL) learners often experience difficulty in mastering English verb tense system. This corpus-based study was conducted to ascertain the most frequently used verb tenses by English native speakers (NSs), specifically in their academic writing in a history course. As this study aimed to examine the naturally-occurring language produced by NSs, specifically in their academic writing, an original corpus of 101,713 words was assembled. The corpus consisted of 130 research papers written by 65 students. The corpus was …
The Effect Of Speech Elicitation Method On Second Language Phonemic Accuracy, Nicole Carrasquel
The Effect Of Speech Elicitation Method On Second Language Phonemic Accuracy, Nicole Carrasquel
Electronic Theses and Dissertations
The present study, a One-Group Posttest-Only Repeated-Measures Design, examined the effect of speech elicitation method on second language (L2) phonemic accuracy of high functional load initial phonemes found in frequently occurring nouns in American English. This effect was further analyzed by including the variable of first language (L1) to determine if L1 moderated any effects found. The data consisted of audio recordings of 61 adult English learners (ELs) enrolled in English for Academic Purposes (EAP) courses at a large, public, post-secondary institution in the United States. Phonemic accuracy was judged by two independent raters as either approximating a standard American …
Climate Change And The Evolution Of Insect Immune Function, Danae Perry
Climate Change And The Evolution Of Insect Immune Function, Danae Perry
Electronic Theses and Dissertations
Insects are ectothermic organisms that have physiological, behavioral and life-history traits directly influenced by their environment. Investigations have shown that many insects use melanin to permanently darken their cuticles in cooler or drier climates to improve thermoregulation and desiccation resistance. Melanin is a major component of pathogen defense in insects. This suggests that environmentally driven adaptive changes in cuticular melanin may non-adaptively shape insect immune function. This hypothesis has been referred to as climate-related Cuticle Dependent Immune Investment (climate-related CDII). Climate-related CDII also suggests that a warming climate could lead to the evolution of a weakened melanin-based immune response due …
The Rest Of The Story: Exploring The Overall Functioning And Maturational Experiences Of Former Foster Youth In Middle Adulthood, Jessica Lynn Yang
The Rest Of The Story: Exploring The Overall Functioning And Maturational Experiences Of Former Foster Youth In Middle Adulthood, Jessica Lynn Yang
Electronic Theses and Dissertations
Middle adulthood as a developmental stage is often neglected in developmental research, yet it is vitally important to the cohesiveness of the life span as this is a time when integrating the experiences of the earlier developmental periods such as emerging adulthood, setting the stage for healthy aging. Emerging adulthood is but one unique stage in the life course, and situating this phase within a holistic developmental context is essential. Doing so illuminates the ways in which the past influences current functioning and the ways in which one's present developmental state sets the stage for later development. To date, no …