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Emotion Regulation And The Experience Of Racial Microaggressions., Broderick Sawyer May 2019

Emotion Regulation And The Experience Of Racial Microaggressions., Broderick Sawyer

Electronic Theses and Dissertations

Racial microaggressions are defined as subtle racial insults or slights that racial minorities may encounter daily, communicating negative messages to victims. Perceiving discrimination has been associated with negative outcomes in racial minorities such as symptoms of depression, anxiety, trauma, and low self-esteem. Previous research has suggested emotion regulation and psychological symptoms as playing significant roles in the experience of discrimination. Research has yet to identify specific emotion regulation tactics that might offset the harm of racial microaggressions. Mindfulness and self-compassion have been found to buffer the negative emotional impact of chronic stressors that are similar to racial microaggressions. The current …

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The Self-Efficacy Of Biological Mothers And Foster Mothers Caring For Infants Prenatally Exposed To Drugs Or Treated For Nas : Examination Of Potentially Influencing Factors., Megan Kathleen Sherehiy May 2019

The Self-Efficacy Of Biological Mothers And Foster Mothers Caring For Infants Prenatally Exposed To Drugs Or Treated For Nas : Examination Of Potentially Influencing Factors., Megan Kathleen Sherehiy

Electronic Theses and Dissertations

This study sought to identify demographic risk and protective factors that may relate to parental self-efficacy in biological and foster mothers caring for infants prenatally exposed to opioids. The study also examined whether participation in treatment for biological mothers and in training for foster mothers was associated with parental self-efficacy. Forty-nine women (21 biological mothers and 28 foster mothers) were surveyed. Measures included demographic, treatment, and training information. A single-item, self-report measure was used to assess satisfaction with support from friends using an item from the World Health Organization Quality of Life-Bref scale (Skevington, Lotfy, & O'Connell, 2004). The Karitane …

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Novel Mechanisms And Biomarkers In Alcohol-Induced Organ Injury., Christine E. Dolin May 2019

Novel Mechanisms And Biomarkers In Alcohol-Induced Organ Injury., Christine E. Dolin

Electronic Theses and Dissertations

Background. Ethanol (EtOH) consumption is known to affect multiple organs; this is unsurprising, as the concentration of EtOH in the blood at relevant doses reaches the millimolar range. The overarching goal of this dissertation was to elucidate mechanisms of alcohol-induced organ injury, specifically the effects of alcohol on the hepatic extracellular matrix (ECM) proteome, the alcoholic hepatitis (AH) plasma peptidome, and the effects of alcohol on the renal cortex proteome and transcriptome. Methods. Mice were pair-fed ethanol-containing liquid diet chronically, and then some mice were administered lipopolysaccharide (LPS). Liver sections from these mice were processed in a series of increasingly …

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Investigating Predictive Relationships Between Speech-Language Pathology Graduate Students' Sense Of Classroom Community, Perceived Learning, And Perceived Anxiety., Emily B. Schantz May 2019

Investigating Predictive Relationships Between Speech-Language Pathology Graduate Students' Sense Of Classroom Community, Perceived Learning, And Perceived Anxiety., Emily B. Schantz

Electronic Theses and Dissertations

Mental health is an all-encompassing term that focuses on a person’s ability to achieve work-life balance inclusive of positive mental health and mental ill-health. Current trends suggest an overall increase in mental ill-health for undergraduate and graduate students. McMillan and Chavis’ sense of community theory provided the theoretical framework for this study. This study aimed to examine whether speech-language pathology graduate students’ sense of classroom community and perceived learning predict anxiety levels while controlling for demographic variables. Three-hundred-sixteen master’s level speech-language pathology students completed an online survey containing the Generalized Anxiety Disorder Questionnaire, Perceived Learning Scale, and Classroom Community Scale. …

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The Q Rule In Bacteriodetes And The Identification And Characterization Of Porphyromonas Gingivalis Glutaminyl Cyclase., John Andrew Houston May 2019

The Q Rule In Bacteriodetes And The Identification And Characterization Of Porphyromonas Gingivalis Glutaminyl Cyclase., John Andrew Houston

Electronic Theses and Dissertations

Background: Porphyromonas gingivalis, a major pathogen associated with chronic periodontitis, secretes variety of proteins, majority of which begins with glutamine. Several of these proteins were found with pyroglutamate (pGlu) at N-terminus suggesting the presence of this posttranslational modification pathway in P.gingivalis. The observation that N-terminal glutamine is over-represented as the first amino acid after signal peptide cleavage, and subsequent confirmation of pGlu formation on the nascent protein via mass spectrometry, led us to conclude that an enzyme must be present as the executor of this reaction. Hypothesis: PG2157 is a glutaminyl cyclase and is responsible for the cyclization of …

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Evaluation Of The Health And Exposure Histories Of A Community Surrounded By Industry And Industrial Waste : A Mixed Methods Approach., Lindsay Koloff Tompkins May 2019

Evaluation Of The Health And Exposure Histories Of A Community Surrounded By Industry And Industrial Waste : A Mixed Methods Approach., Lindsay Koloff Tompkins

Electronic Theses and Dissertations

Environmental pollution is not distributed equally across members of society. Low-income individuals are more likely to live near waste sites and other sources of pollution, and, therefore, face greater exposure to environmental health hazards. One such community in Louisville, Kentucky, the Riverside Gardens neighborhood, consists of approximately 300 homes that are surrounded on three sides by industry and industrial waste, including a remediated Environmental Protection Agency Superfund site, a former coal-burning power plant and coal ash storage site, and multiple chemical, rubber, and plastic manufacturing companies. Residents have reported elevated rates of cancer and other chronic diseases and have requested …

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Exploring The Role Of Ptn1 In Ustilago Maydis., Lalu Murali Krishna Vijayakrishna Pillai May 2019

Exploring The Role Of Ptn1 In Ustilago Maydis., Lalu Murali Krishna Vijayakrishna Pillai

Electronic Theses and Dissertations

Signal transduction is a key aspect of biological life. Cell signaling involves a series of biochemical and molecular steps that regulate the normal cellular functions, and any disruption at any of these steps is likely to have substantial impacts on cell physiology. The current study was aimed at the characterization of ptn1 of Ustilago maydis, a basidiomycete fungus. When the U. maydis, ptn1 gene was either deleted or overexpressed, it was found that the deletion of this gene lead to reduced virulence, spore production, and germination rate; effects of the overexpression were more subtle or not discernable. Previous studies …

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Polydrug Use Among People Who Use Opioids, National Survey On Drug Use And Health 2002 To 2017., Diana Kuo Stojda May 2019

Polydrug Use Among People Who Use Opioids, National Survey On Drug Use And Health 2002 To 2017., Diana Kuo Stojda

Electronic Theses and Dissertations

Introduction: Mortality due to overdose has been increasing since 2010 in the U.S., with an increase in the reported use of heroin and co-use of heroin and prescription opioids. Trends and correlates of polydrug use need to be analyzed to propose policies to reduce overdose risk. The overall objective of this study is to characterize high-risk polydrug groups among people who use opioids (PWUO) to understand the patterns of co-used substances and overdose risk factors. Methods: Publicly available data from the 2002-2017 National Survey on Drug Use and Health were analyzed to obtain weighted prevalence rates and trends …

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Synthesis, Characterization, And Evaluation Of Metal Complexes With Cancer Selective Anti-Proliferative Effects And Hydrogen Evolution Catalytic Properties., Nicholas Vishnosky May 2019

Synthesis, Characterization, And Evaluation Of Metal Complexes With Cancer Selective Anti-Proliferative Effects And Hydrogen Evolution Catalytic Properties., Nicholas Vishnosky

Electronic Theses and Dissertations

Bis-thiosemicarbazones (BTSC) and their metal chelates have properties that are useful in several different scientific fields. These systems have already received attention in major fields of biology and engineering. Hydrogen evolution reaction (HER) catalysts need to be cheap and operate under minimal overpotentials with a long lifetime. The treatment of cancer requires, novel agents that have potent cytotoxic activity against cancer cells while displaying minimal side effects. In this dissertation the modular synthesis of these bis-thiosemicarbazone systems is utilized to regulate the redox chemistry for employment in the desired sector of chemistry. The ligand and metal chelates synthesized were characterized …

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Marginal Staining Between Pressed Lithium Disilicate Ceramic Crowns And Direct Restorative Materials By Various Fluids : A Microleakage Study., Sarah Ann Jestel May 2019

Marginal Staining Between Pressed Lithium Disilicate Ceramic Crowns And Direct Restorative Materials By Various Fluids : A Microleakage Study., Sarah Ann Jestel

Electronic Theses and Dissertations

When treating patients with existing restorations in which indirect restoration placement is indicated and crown lengthening surgery is contraindicated, dentists may choose to finish the crown margin on an existing restoration. The interface between the two dental restorations (resin composite and ceramic crown) may be more susceptible to microleakage and fluid staining, reducing restoration longevity. In this study, 80 extracted molars received indirect restoration margins finished on different direct restorative materials (resin-modified glass ionomer and conventional, flowable, and bulk fill nano-hybrid resin composite) and subjected to common staining fluids of coffee, tea, red wine, or Coca-Cola. If the clinician must …

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The Emergent Matter Of Archives : A Rhetorical Investigation Of The Queer Formation Of The Williams-Nichols Archive., Richard Wysocki May 2019

The Emergent Matter Of Archives : A Rhetorical Investigation Of The Queer Formation Of The Williams-Nichols Archive., Richard Wysocki

Electronic Theses and Dissertations

Scholarly conversations across disciplines have asked researchers to consider archive as a site of power—often framed in terms of archives’ potential impact on history and practices of knowledge making more generally. This dissertation contributes to such conversations as they relate to queer archives and material rhetoric, exploring the Williams-Nichols Archive, an LGBTQ archive housed at the University of Louisville. I extend interdisciplinary scholarship to argue for approaching archives as rhetorical emergences rather than as containers or locations for discovery, a perspective that foregrounds the archive and archival practices as the subject of research. Drawing on archival research and oral history …

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An Evaluation Of The Supply And Demand Of Radiation Oncology Medical Physicists In The United States., Christine Marie Swanson May 2019

An Evaluation Of The Supply And Demand Of Radiation Oncology Medical Physicists In The United States., Christine Marie Swanson

Electronic Theses and Dissertations

Background: This dissertation is a mixed methods evaluation of the radiation oncology medical physics workforce in the United States. Radiation oncology medical physicists serve a vital role in the safe treatment of patients with radiation therapy. While cancer incidence continues to rise, the pathways to board certification in radiation oncology medical physics continue to narrow causing a potential shortage of radiation oncology physicists in the United States. While there is no lack of data about the medical physics community it has scarcely been used to evaluate the current state of the workforce. In order to ensure patient safety, appropriate physics …

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Development Of A Lectin-Fc Fusion Protein With Antiviral And Anti-Cancer Activity., Matthew William Dent May 2019

Development Of A Lectin-Fc Fusion Protein With Antiviral And Anti-Cancer Activity., Matthew William Dent

Electronic Theses and Dissertations

This thesis describes the development of a novel lectin-Fc fusion protein and its antiviral and anti-cancer activity. The molecule, Avaren-Fc (AvFc), is a fusion of a variant of the actinomycete lectin actinohivin (Avaren) and the Fc region of human IgG1, and is selective for the terminal α1,2-mannose residues found at the ends of high-mannose-type glycans that can be found on the surface of certain heavily glycosylated viruses and cancer cells. Here, AvFc was found to be able to neutralize simian immunodeficiency virus as well as Hepatitis C virus with nanomolar IC50 values. Furthermore, AvFc recognizes a number of cell …

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Paraoxonase 2 Is Critical For Non-Small Cell Lung Carcinoma Proliferation., Aaron Whitt May 2019

Paraoxonase 2 Is Critical For Non-Small Cell Lung Carcinoma Proliferation., Aaron Whitt

Electronic Theses and Dissertations

Non-small cell lung carcinoma (NSCLC) comprises 85% of lung cancer diagnoses and is plagued by drug resistance. Thus, elucidating the underlying mechanisms of NSCLC is paramount to expand future treatment options. Paraoxonase 2 (PON2), an intracellular enzyme with arylesterase and lactonase functions, has well-established anti-atherosclerotic activity. Recent studies show PON2 is overexpressed in a variety of tumors and confers drug resistance, although these interactions have not been thoroughly examined in NSCLC. Thus, we sought to investigate the role of PON2 in cellular proliferation using PON2-knockout mice, primary mouse cells, and NSCLC cell lines. Using these approaches, we demonstrate that PON2 …

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Receptive Fields Optimization In Deep Learning For Enhanced Interpretability, Diversity, And Resource Efficiency., Babajide Odunitan Ayinde May 2019

Receptive Fields Optimization In Deep Learning For Enhanced Interpretability, Diversity, And Resource Efficiency., Babajide Odunitan Ayinde

Electronic Theses and Dissertations

In both supervised and unsupervised learning settings, deep neural networks (DNNs) are known to perform hierarchical and discriminative representation of data. They are capable of automatically extracting excellent hierarchy of features from raw data without the need for manual feature engineering. Over the past few years, the general trend has been that DNNs have grown deeper and larger, amounting to huge number of final parameters and highly nonlinear cascade of features, thus improving the flexibility and accuracy of resulting models. In order to account for the scale, diversity and the difficulty of data DNNs learn from, the architectural complexity and …

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An Assessment Of Sustainability In Jefferson County Public Schools (Kentucky)., Elizabeth Ann Ruhe May 2019

An Assessment Of Sustainability In Jefferson County Public Schools (Kentucky)., Elizabeth Ann Ruhe

Electronic Theses and Dissertations

Schools play a vital role in preparing the next generation of citizens to be active, engaged, creative thinkers and problem-solvers. Schools are also large institutions in their communities, employing many people and spending large sums of money. What happens in schools has an impact on their surrounding communities. Human behaviors are having a significant impact on our planet and changes in our society are affecting the sense of safety and security of our citizens. These are aspects of sustainability that schools need to begin addressing. This research looks at sustainability practices in a large urban school district to document current …

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Speech Articulation In Children With Williams Syndrome Or 7q11.23 Duplication Syndrome., Myra Jean Fallon Huffman May 2019

Speech Articulation In Children With Williams Syndrome Or 7q11.23 Duplication Syndrome., Myra Jean Fallon Huffman

Electronic Theses and Dissertations

Williams syndrome (WS) and 7q11.23 duplication syndrome (Dup7) are associated with communication disorders (Huffman et al., 2013). However, articulatory accuracy has not been systematically examined in these populations. The dissertation involved two studies. Using standardized citation assessment, Study 1 addressed articulatory accuracy with regard to age norms and differences between groups. Results indicated that for both groups, (a) consonant accuracy was significantly below expectations, (b) older children pronounced consonants with significantly better accuracy than younger children, (c) children with IQs at or above 70 earned significantly higher articulation standard scores, and (d) for particular groups of consonant sounds, arranged as …

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The Elite Meroitic Experience On Sai Island, Sudan: Using Stable Isotope Analysis To Identify Patterns Related To Sex And Age For The Interpretation Of Social Identity, Alexandria Brock May 2019

The Elite Meroitic Experience On Sai Island, Sudan: Using Stable Isotope Analysis To Identify Patterns Related To Sex And Age For The Interpretation Of Social Identity, Alexandria Brock

Electronic Theses and Dissertations

The research conducted for this thesis utilized stable isotope analysis to reconstruct the diet of 35 individuals from an elite Meroitic (350 BC – 300 AD) cemetery (site 8.B.5A) located on Sai Island, Sudan, with a focus on adult age categories and biological sex, to understand intraclass variation in diet. Stable carbon and nitrogen values from human bone collagen were used to understand elite social organization, social practice, and gender roles in the Meroitic period through the lens of social identity and post-processual theories. The samples were grouped based on biological sex, median age, and assigned age categories (young, middle, …

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Miami-Dade Task Force: A Content Analysis Of How Coastal Communities View Sea Level Rise As A Threat, Francisco Alvaro May 2019

Miami-Dade Task Force: A Content Analysis Of How Coastal Communities View Sea Level Rise As A Threat, Francisco Alvaro

Electronic Theses and Dissertations

Sea level rise (SLR) has become a serious threat for coastal communities in recent years. Many communities, including South Florida, are already having the security of their daily lives impacted as climate change causes SLR and other environmental impacts to worsen. This study reviews the Miami-Dade Sea Level Rise Task Force Report to determine how this coastal county government views SLR as a threat. Using mixed content analysis to analyze the report qualitatively and quantitatively, the Task Force's recommendations are categorized based on their focus on security, infrastructure, economics, and the environment. One finds the concerns of the people to …

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Do Per-Capita Impact Or Abundance Dominate The Impact Of An Invader? Interactions Among Neighboring Species In Context-Dependent Competition, Haoyu Li May 2019

Do Per-Capita Impact Or Abundance Dominate The Impact Of An Invader? Interactions Among Neighboring Species In Context-Dependent Competition, Haoyu Li

Electronic Theses and Dissertations

Evaluating relative species competitive strength is a central question in community ecology, with strong implications for invasion ecology. Models assessing invader success consider three components: distribution, abundance and per-capita impact. However, relative strength and interactions among these factors remain unclear when applying to specific invasion scenarios. We hypothesized that performance of native and non-native species will vary as a function of direct and indirect effects at different abundances and scales. We conducted a replacement experiment between two dominant grasses in subtropical grasslands (the native Axonopus fissifolius and the non-native Paspalum notatum) in central Florida, USA. Thirty fenced plots (1 m …

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A Deep Learning Approach To Diagnosing Schizophrenia, Justin Barry May 2019

A Deep Learning Approach To Diagnosing Schizophrenia, Justin Barry

Electronic Theses and Dissertations

In this article, the investigators present a new method using a deep learning approach to diagnose schizophrenia. In the experiment presented, the investigators have used a secondary dataset provided by National Institutes of Health. The aforementioned experimentation involves analyzing this dataset for existence of schizophrenia using traditional machine learning approaches such as logistic regression, support vector machine, and random forest. This is followed by application of deep learning techniques using three hidden layers in the model. The results obtained indicate that deep learning provides state-of-the-art accuracy in diagnosing schizophrenia. Based on these observations, there is a possibility that deep learning …

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Zika Virus-Induced Lysis Of Cervical Cancer Cells, Harini Krishnapura May 2019

Zika Virus-Induced Lysis Of Cervical Cancer Cells, Harini Krishnapura

Electronic Theses and Dissertations

Cervical cancer is the fourth most frequent cancer in women with an estimated 570,000 new cases globally in 2018. Treatment of advanced cervical cancer is often unsuccessful leading to high cancer-related mortality rates, especially in under-resourced countries. Recently, a possible role for the cell surface glycoprotein CD24 in host cell specificity of Zika virus was reported. As an extension of this work, Zika viruses have been proposed as oncolytic therapy for the treatment of neuroblastoma and other CD24 positive tumors. To determine the permissiveness of cervical cancer cells to Zika virus infection and its association with CD24, we assessed cytopathic …

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Concerning The Perceptive Gaze: The Impact Of Vision Theories On Late Nineteenth-Century Victorian Literature, Lindsay Rushworth May 2019

Concerning The Perceptive Gaze: The Impact Of Vision Theories On Late Nineteenth-Century Victorian Literature, Lindsay Rushworth

Electronic Theses and Dissertations

This thesis examines two specific interventions in vision theory—namely, Herbert Spencer's theory of organic memory, which he developed by way of Lamarckian genetics and Darwinian evolution in A System of Synthetic Philosophy (1864), and the Aesthetic Movement (1870s–1890s), famously articulated by Walter Pater in The Renaissance: Studies in Art and Poetry (1873 and 1893). I explore the impact of these theories on late nineteenth-century fiction, focusing on two novels: Thomas Hardy's Two on a Tower (1882) and Edith Johnstone's A Sunless Heart (1894). These two authors' texts engage with scientific and aesthetic visual theories to demonstrate their anxieties concerning the …

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Decentralized Consensus-Based Control Allocation For Some Dynamical Systems, August Mark May 2019

Decentralized Consensus-Based Control Allocation For Some Dynamical Systems, August Mark

Electronic Theses and Dissertations

In this dissertation, three separate studies, wherein techniques from graph theory and consensus control are used to address control allocation problems, are presented. In the first study, a decentralized allocator is presented for synthetic jet actuators and control surfaces onboard a small unmanned aerial vehicle to cooperatively generate desired aerodynamic moments. First order linear dynamics are assumed for both the synthetic jet actuators and control surfaces. A weighted consensus algorithm with limited feedback is used for the aerodynamic moment contribution allocator considering constraints. In the second study, the same allocation problem as in the first study is considered, but the …

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Synergistic Visualization And Quantitative Analysis Of Volumetric Medical Images, Neslisah Torosdagli May 2019

Synergistic Visualization And Quantitative Analysis Of Volumetric Medical Images, Neslisah Torosdagli

Electronic Theses and Dissertations

The medical diagnosis process starts with an interview with the patient, and continues with the physical exam. In practice, the medical professional may require additional screenings to precisely diagnose. Medical imaging is one of the most frequently used non-invasive screening methods to acquire insight of human body. Medical imaging is not only essential for accurate diagnosis, but also it can enable early prevention. Medical data visualization refers to projecting the medical data into a human understandable format at mediums such as 2D or head-mounted displays without causing any interpretation which may lead to clinical intervention. In contrast to the medical …

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Heterogeneous Reconfigurable Fabrics For In-Circuit Training And Evaluation Of Neuromorphic Architectures, Ramtin Mohammadizand May 2019

Heterogeneous Reconfigurable Fabrics For In-Circuit Training And Evaluation Of Neuromorphic Architectures, Ramtin Mohammadizand

Electronic Theses and Dissertations

A heterogeneous device technology reconfigurable logic fabric is proposed which leverages the cooperating advantages of distinct magnetic random access memory (MRAM)-based look-up tables (LUTs) to realize sequential logic circuits, along with conventional SRAM-based LUTs to realize combinational logic paths. The resulting Hybrid Spin/Charge FPGA (HSC-FPGA) using magnetic tunnel junction (MTJ) devices within this topology demonstrates commensurate reductions in area and power consumption over fabrics having LUTs constructed with either individual technology alone. Herein, a hierarchical top-down design approach is used to develop the HSCFPGA starting from the configurable logic block (CLB) and slice structures down to LUT circuits and the …

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Mechanical Properties Of Brittle Ceramics: Case Study Of Boron Rich Ceramics And Acropora Cervicornis Coral Skeleton, Alejandro Carrasco-Pena May 2019

Mechanical Properties Of Brittle Ceramics: Case Study Of Boron Rich Ceramics And Acropora Cervicornis Coral Skeleton, Alejandro Carrasco-Pena

Electronic Theses and Dissertations

Ceramics are ubiquitous in man-made and natural structures. Their mechanical properties highly depend on their composition, microstructure and level of defects in the bulk of the material, the latter affecting the integrity of the components; such is the case of boron-rich ceramics where large agglomerates create high stressed regions, or coral skeleton where porosity determines their strength against hydrodynamic forces present in the ocean tides. Therefore, studying the properties of ceramic materials using invasive and non-invasive methods helps in the understanding of the link between the properties and the performance of the structures. The aim of this research was to …

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Federal, State And Local Law Enforcement Agency Interoperability Capabilities And Cyber Vulnerabilities, Tyrone Trapnell May 2019

Federal, State And Local Law Enforcement Agency Interoperability Capabilities And Cyber Vulnerabilities, Tyrone Trapnell

Electronic Theses and Dissertations

The National Data Exchange (N-DEx) System is the central informational hub located at the Federal Bureau of Investigation (FBI). Its purpose is to provide network subscriptions to all Federal, state and local level law enforcement agencies while increasing information collaboration across all domains. The National Data Exchange users must satisfy the Advanced Permission Requirements, confirming the terms of N-DEx information use, and the Verification Requirement (verifying the completeness, timeliness, accuracy, and relevancy of N-DEx information) through coordination with the record-owning agency (Management, 2018). A network infection model is proposed to simulate the spread impact of various cyber-attacks within Federal, state …

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Predicting Students' Academic Performance With Decision Tree And Neural Network, Junshuai Feng May 2019

Predicting Students' Academic Performance With Decision Tree And Neural Network, Junshuai Feng

Electronic Theses and Dissertations

Educational Data Mining (EDM) is a developing research field that involves many techniques to explore data relating to educational background. EDM can analyze and resolve educational data with computational methods to address educational questions. Similar to EDM, neural networks have been utilized in widespread and successful data mining applications. In this paper, synthetic datasets are employed since this paper aims to explore the methodologies such as decision tree classifiers and neural networks to predict student performance in the context of EDM. Firstly, it introduces EDM and some relative works that have been accomplished previously in this field along with their …

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Variable Fluid Flow Regimes Alter Endothelial Adherens Junctions And Tight Junctions, Dilshan Ranadewa May 2019

Variable Fluid Flow Regimes Alter Endothelial Adherens Junctions And Tight Junctions, Dilshan Ranadewa

Electronic Theses and Dissertations

Variable blood flow regimes influence a range of cellular properties ranging from cell orientation, shape, and permeability: all of which are dependent on endothelial cell-cell junctions. In fact, cell-cell junctions have shown to be an integral part of vascular homeostasis through the endothelium by allowing intercellular signaling and passage control through tight junctions (TJs), adherens junctions (AJs), and gap junctions (GJs). It was our objective to determine the structural response of both AJs and TJs under steady and oscillatory flow. Human brain microvascular endothelial cells (HBMECs) were cultured in a parallel plate flow chamber and exposed to separate trails of …

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