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Statistical Methods For Assessing Treatment Effects On Ordinal Outcomes And Selecting Optimal Treatment On Survival Outcomes Using Observational Data., Huirong Hu
Electronic Theses and Dissertations
This dissertation consists of two projects investigating statistical methods in causal inference and personalized medication using observational data. In the first project, we propose a parametric marginal structural ordinal logistic regression model (MS-OLRM) to assess treatment effects on ordinal outcomes. Average treatment effect (ATE) is used to measure the difference of the mean outcomes if all patients would have been treated compared with the outcomes if they would not have been treated. Many statistical methods have been developed to estimate ATE when the outcome is continuous or binary. The methodology on assessing treatment effect for an ordinal outcome is less …
From Androgyny To Binary And Back: A Qualitative Analysis Of Nonbinary Tiktoks., Savannah Hatton
From Androgyny To Binary And Back: A Qualitative Analysis Of Nonbinary Tiktoks., Savannah Hatton
Electronic Theses and Dissertations
This study explores how nonbinary individuals represent and express their gender on TikTok. Given the limited amount of research that has been done on nonbinary gender expression in online spaces, this study uses TikTok to observe the ways that nonbinary individuals perform gender. Additionally, given the relative newness of TikTok, this study serves to inform growing research on identity formation through social media. It used a sample of fifty TikToks by nonbinary creators to perform a content analysis. The findings reveal significant variation in how nonbinary individuals "do gender" on the platform, with some individuals identifying closely with binary labels, …
Aurka Inhibition-Based Combination Therapy Approaches In Glioblastoma., Muge Sak
Aurka Inhibition-Based Combination Therapy Approaches In Glioblastoma., Muge Sak
Electronic Theses and Dissertations
Glioblastoma is the most common and aggressive central nervous system tumor in adults with a 6% survival rate. Decades of research for improving life expectancy and quality of life have been ineffective. The discovery of better treatment strategies is urgent to improve the survival rates for glioblastoma patients. Aurora Kinase A is a regulator of tumor progression and is overexpressed in glioblastoma. We used a specific Aurora Kinase A inhibitor alisertib in combination with DNA-damaging platinum agent carboplatin or brain-penetrating taxane TPI 287. We investigated the efficacy of these combinations in treating in vitro and in vivo tissue culture models …
A Data-Driven Multi-Regime Approach For Predicting Real-Time Energy Consumption Of Industrial Machines., Abdulgani Kahraman
A Data-Driven Multi-Regime Approach For Predicting Real-Time Energy Consumption Of Industrial Machines., Abdulgani Kahraman
Electronic Theses and Dissertations
This thesis focuses on methods for improving energy consumption prediction performance in complex industrial machines. Working with real-world industrial machines brings several challenges, including data access, algorithmic bias, data privacy, and the interpretation of machine learning algorithms. To effectively manage energy consumption in the industrial sector, it is essential to develop a framework that enhances prediction performance, reduces energy costs, and mitigates air pollution in heavy industrial machine operations. This study aims to assist managers in making informed decisions and driving the transition towards green manufacturing. The energy consumption of industrial machinery is substantial, and the recent increase in CO2 …
Cad System For Early Diagnosis Of Diabetic Retinopathy Based On 3d Extracted Imaging Markers., Ahmed Sleman
Cad System For Early Diagnosis Of Diabetic Retinopathy Based On 3d Extracted Imaging Markers., Ahmed Sleman
Electronic Theses and Dissertations
This dissertation makes significant contributions to the field of ophthalmology, addressing the segmentation of retinal layers and the diagnosis of diabetic retinopathy (DR). The first contribution is a novel 3D segmentation approach that leverages the patientspecific anatomy of retinal layers. This approach demonstrates superior accuracy in segmenting all retinal layers from a 3D retinal image compared to current state-of-the-art methods. It also offers enhanced speed, enabling potential clinical applications. The proposed segmentation approach holds great potential for supporting surgical planning and guidance in retinal procedures such as retinal detachment repair or macular hole closure. Surgeons can benefit from the accurate …
Experimental And Numerical Studies Of Laser Powder-Bed Fusion Process With Ti-6al-4v Powder: (1) Porosity And Mechanical Properties, And (2) Transient Phenomena In One- And Two-Dimensional Fabrications., Santosh K. Rauniyar
Electronic Theses and Dissertations
Laser powder bed fusion (L-PBF) process represents a form of metal additive manufacturing (AM) where micron-level powdered material is selectively melted and fused layer by layer to create intricate three-dimensional parts. This process involves rapid melting and solidification, leading to intense thermocapillary convection within the molten pool. The melt pool is a crucial element of the L-PBF process and refers to the localized region where the powder particles are melted and solidified to form each layer of the printed part. The shape and dimensions of the melt pool directly influence the accuracy and surface finish of the printed part. Precise …
Using Graphic Novels To Teach Economics Content To High School Students With Extensive Support Needs., Caroline Mae Fitchett
Using Graphic Novels To Teach Economics Content To High School Students With Extensive Support Needs., Caroline Mae Fitchett
Electronic Theses and Dissertations
The purpose of social studies instruction in school is to facilitate the growth of competent citizens (National Council for the Social Studies [NCSS], 2013). Despite the recognized benefit of social studies instruction, emphasis on this subject has decreased over time, and has ultimately been termed a “dispensable subject” (Fitchett & Haefner, 2010). Social studies is an even more marginalized subject area for students with disabilities (Zakas et al., 2013). Expanding the research in this area is not only necessary to improving social studies academic content acquisition but is also likely to facilitate greater independence for students post-school – and by …
Perception Is Reality! How Perception Shapes Our World., Nicole Clay
Perception Is Reality! How Perception Shapes Our World., Nicole Clay
Electronic Theses and Dissertations
This thesis is an examination of the role different photography techniques play in how images are perceived. There have existed techniques for manipulating the perception of images since the creation of the camera. The techniques examined in this paper are editing, staging, and the use of captions. In recent years, perception has become a powerful tool for political parties to manipulate. This manipulation of perception has led to an increasing distrust in the images the media presents to the public. This paper does not seek to answer any questions but to encourage people to have a greater understanding of photography.
The Role Of E-Liquid Constituents In E-Cigarette-Induced Cardiac Arrhythmia And Autonomic Imbalance., Cory Kucera
The Role Of E-Liquid Constituents In E-Cigarette-Induced Cardiac Arrhythmia And Autonomic Imbalance., Cory Kucera
Electronic Theses and Dissertations
Introduction. Accumulating evidence indicates that exposure to electronic cigarettes (e-cigs) promotes sympathetic dominance and electrophysiologic instability in the heart, potentially culminating in arrhythmogenesis. E-liquids contain various formulations of nicotine and flavorings, but the effects of specific e-liquid constituents and their concentrations on e-cig-induced autonomic imbalance and electrical dysfunction are unresolved. To that end, we tested the hypothesis that e-cigs modify cardiac autonomic balance and ventricular arrhythmogenesis in mice dependent on e-liquid constituent type and concentration. Methods. Using a crossover design and a serial exposure regimen, ECG-telemetered male C57BL/6J mice underwent whole-body exposure to e-cig aerosols generated from e-liquids containing different …
Reservoir Characterization Of The Utica Shale Play Using Well Log Data In Columbiana, Ohio, Tyler L. West
Reservoir Characterization Of The Utica Shale Play Using Well Log Data In Columbiana, Ohio, Tyler L. West
Electronic Theses and Dissertations
The Ordovician Utica shale play is rapidly developing throughout the Appalachian Basin. The play is a mixed carbonate-siliciclastic system that grades from primarily carbonates at its base in the Lexington/Trenton limestones into primarily shale within the Utica shale. As of January 2021, it is the third highest-producing dry shale gas play in the contiguous U.S., although it is known to produce wet gas and oil in various parts of the basin. In addition to being an unconventional reservoir, the Utica shale, an informal unit in Ohio where the main fairway is located, is a known source rock for much of …
A Practice-Based Inquiry Into The Correlation Between Nursing Retention Rates And Resiliency, Kelly J. Watson
A Practice-Based Inquiry Into The Correlation Between Nursing Retention Rates And Resiliency, Kelly J. Watson
Electronic Theses and Dissertations
Nurses are the frontline in the security of the United States. Their wellbeing and retention in the workforce is of the utmost of importance. Nurses are leaving at increasing levels with just over 27% turnover rates across the nation in 2021. Organizations are experiencing increasing fiscal losses and the average loss for a nurse leaving is just over $46,000. The prioritization of nurses’ wellbeing and taking steps to address policy that promotes the sustainability of this very valuable workforce has the potential to pay high dividends for nurses individually, the security of the nation, and the good of the organization. …
Persistence And Retention Of Adult Learners: Results Of A Program Evaluation Of Tuition Funding Provided By Employers, Andrea J. Gross
Persistence And Retention Of Adult Learners: Results Of A Program Evaluation Of Tuition Funding Provided By Employers, Andrea J. Gross
Electronic Theses and Dissertations
As the looming enrollment cliff approaches and more adult learners return to higher education, understanding the factors that affect their persistence and retention is vital for higher education institutions. Previous studies have shown that external factors influence post-traditional learners’ pursuit of higher education. This program evaluation aimed to acquire knowledge of up-front employer tuition funding and its effects on adult learners' persistence, retention, and time to degree completion. Through a quantitative approach, this program evaluation examines the differences between students receiving up-front employer tuition funding and those who do not. The results indicated that students who received employer funding retained …
Exploring Collective Impact: A Developmental Program Evaluation Of A College Access Program, Diana C. Zakhem
Exploring Collective Impact: A Developmental Program Evaluation Of A College Access Program, Diana C. Zakhem
Electronic Theses and Dissertations
The Partnership was established in 2015 when the Arbor Glen School District, Brook Heights Community College, and Remarkable Outcomes rallied around their common priorities of increasing college matriculation rates in their community. The Partnership created programming that promotes the preparation and transition of students into postsecondary education and the completion of a postsecondary credential. The COVID-19 global pandemic directly impacted The Partnership, including the loss of grant funding, changes in data reporting systems, changes in the delivery method of its services to students, and significant staff turnover. The combination of these factors caused The Partnership’s organizational structure, measurement systems, activities, …
Understanding Associations Between Chronic Illness Identity, Psychological Flexibility, And Type 2 Diabetes Emotional, Behavioral, And Psychosocial Functioning., Valery Bodziony
Electronic Theses and Dissertations
Introduction: Illness identity, defined as the extent to which one integrates their illness into their sense of self, may be a key psychological factor to consider in overall adjustment to and management of Type 2 Diabetes. Emerging research suggests illness identity integration is associated with aspects of diabetes-specific functioning. Psychological flexibility has also been found to be associated with positive diabetes-specific functioning. This modifiable cognitive factor may play a role in the relationship between illness identity and diabetes-specific functioning. This study aims to examine associations between illness identity enrichment, illness identity rejection, psychological flexibility, and aspects of diabetes-functioning, including self-management …
Institutional Racism, Racial Trauma, And Mental Health In Bipoc Graduate Students And Professionals., Jody Zhong
Institutional Racism, Racial Trauma, And Mental Health In Bipoc Graduate Students And Professionals., Jody Zhong
Electronic Theses and Dissertations
While there is increasing mainstream focus on diversity, equity, and inclusion (DEI) amongst U.S. college campuses, institutional racism and everyday racist events continue to be common experiences for Black/Brown, Indigenous, and People of Color (BIPOC) students (Bartz, 2019; Noltemeyer et al., 2012; Pieterse et al., 2010; Regis, 2016; Vaishnav, 2020). Research has shown that subtle, everyday racist slights, known as microaggressions, can have a substantial effect on the mental health and functioning of BIPOC, leading to the development of posttraumatic stress and to negative impacts on psychological well-being (Abdullah et al., 2021; Le et al., 2021; Lui & Quezada, 2019; …
“Long Live Ear X-Tacy!”: An Oral History Study Of Rhetorics Of Nostalgia And Place., Aubrie Warner
“Long Live Ear X-Tacy!”: An Oral History Study Of Rhetorics Of Nostalgia And Place., Aubrie Warner
Electronic Theses and Dissertations
This study aims to explore rhetorical placemaking through how people understand and construct narratives around places that no longer exist. In doing so, it examines the relationship between nostalgia and place — how rhetorical construction of place is influenced and/or informed by rhetorics of nostalgia, how our experiences influence our sense of place (past and present), and how we create continuity for ourselves in the construction and maintenance of particular narratives. This study contributes to the emerging field of rhetorics of nostalgia and places it in direct conversation with rhetorics of place and unpacks how these two are more connected …
False Memories Are Impacted By Semantic Pairing Of Drm Lists., Ryan Coleman
False Memories Are Impacted By Semantic Pairing Of Drm Lists., Ryan Coleman
Electronic Theses and Dissertations
In the DRM paradigm, experience of semantically related words leads to false memories of related words called critical lures. These false memories serve as evidence that the relationship between items in a DRM list contribute to an overall gist or central concept for the experience. The present studies aim to investigate whether the higher-order semantic relationship that exists between different DRM lists can also influence recognition memory. Study 1 compared memory confidence ratings for list items and critical lures to two metrics: “Temporal Contiguity”, how closely in time lists appeared to each other at encoding, and “Semantic Distance”, the semantic …
Why Are Measures Of Depression Imperfectly Correlated? An Empirical Investigation., Eric Joseph Smith
Why Are Measures Of Depression Imperfectly Correlated? An Empirical Investigation., Eric Joseph Smith
Electronic Theses and Dissertations
Depression remains one of the most prevalent and impactful mental health disorders worldwide. A large number of measures of depressive symptoms are currently available, all designed to assess the same underlying construct. However, the measures tend not to correlate highly with one another. Measurement error cannot fully account for this observation, suggesting that clinical heterogeneity – that is, differences in symptom coverage across measures – might contribute to the lower-than-expected correlation between measures. We conducted two concurrent studies to examine this hypothesis. In Study 1, we developed a coding scheme to categorize items into one of 10 symptom categories. We …
Injury Induced Neuroplasticity And Cell Specific Targeting Of The Lumbar Enlargement For Gene Therapy., Brandon Lee Brown
Injury Induced Neuroplasticity And Cell Specific Targeting Of The Lumbar Enlargement For Gene Therapy., Brandon Lee Brown
Electronic Theses and Dissertations
This dissertation is an examination of spinal cord injury induced neuroplasticity and tests whether noninvasive gene therapy can successfully target neurons in the lumbar spinal cord. It begins with an overview of neural control of locomotion and a brief summary of therapeutics that are used and/or in development for treating spinal anatomically characterize s subset of neurons in the spinal cord, long ascending propriospinal neurons, that are involved in interlimb coordination. Characterization of these neurons allows for subsequent evaluation of their potential involvement in injury induced neuroplasticity. This dissertation is divided into five chapters, covering spinal cord injury and therapeutics. …
Development And Applications Of Novel And Practical Fluorination Reagents., Yuhao Yang
Development And Applications Of Novel And Practical Fluorination Reagents., Yuhao Yang
Electronic Theses and Dissertations
The fluorine (F) atom has distinctive properties such as the highest electronegativity, small size, low polarizability, and strong C–F bond strength. Not surprisingly, fluorinated organic compounds have garnered significant attention in the pharmaceutical, agrochemical, and material fields. Since organofluorides are very rare in nature, we need fluorination reagents to help us transfer fluorine into the organic molecules. In past decades, a vast number of fluorination reagents have been developed and many of them are commercially available now. However, there is still much room for the improvement of these reagents. Our target is to develop novel and practical fluorination reagents to …
Food Insecurity And Residential Segregation Among Adults In The United States: The National Health And Nutrition Examination Survey 2017- March 2020 Pre-Pandemic Data., Chandre' L. Chaney
Food Insecurity And Residential Segregation Among Adults In The United States: The National Health And Nutrition Examination Survey 2017- March 2020 Pre-Pandemic Data., Chandre' L. Chaney
Electronic Theses and Dissertations
Food insecurity is when a household has insufficient food supply due to limited economic resources. It is a public health issue that continues to persist. The health, social, and economic impact affects millions of people nationwide. Residential segregation is a primary cause of inequities and health disparities. It shapes the differences in socio-economic conditions between Blacks and Whites living in the U.S. This country is segregated across racial lines in many of our most populated metropolitan cities. Americans worship in different churches, learn in disparate schools, and live in separate neighborhoods. Residential segregation has consequences that impact the economy, professional …
Swallow, Breathing And Survival: Sex-Specific Effects Of Opioids., Michael Frazure
Swallow, Breathing And Survival: Sex-Specific Effects Of Opioids., Michael Frazure
Electronic Theses and Dissertations
This dissertation presents a series of studies examining mechanisms of deglutition and respiration, and how these vital processes are impacted by opioids. The experiments in Chapter Two investigated the role of the upper esophagus in airway protection through systematic activation of pharyngeal and esophageal mechanoreceptors in a cat electromyography model. Chapter Three compared effects of opioid administration on breathing and swallowing between male and female rats, and found that females are more susceptible to opioid-induced depression of breathing and swallow than males. Findings from Chapters Two and Three led to the development of a translational model of opioid-induced dysphagia using …
Inhibition Of Ras As A Novel Therapeutic Approach In Luminal B Breast Cancer., Raphael Ngozichi Jigo
Inhibition Of Ras As A Novel Therapeutic Approach In Luminal B Breast Cancer., Raphael Ngozichi Jigo
Electronic Theses and Dissertations
Historically, the RAS oncoprotein has not been implicated in breast cancer due to less than 1% of breast cancer cases bearing oncogenic RAS mutations. Recently, however, it has been reported that greater than 60% of Luminal B breast cancer cases have a decreased expression of negative RAS regulators RASAL2 and DAB2IP. Thus, in many Luminal B breast cancers, RAS remains in a constitutively active state without mutation, in turn driving oncogenesis. To date, there are no FDA-approved direct inhibitors of wild type RAS. We have developed a direct RAS inhibitor that acts on wild type RAS using in silico drug …
New Species Of Dryolestoid From The Late Cretaceous Allen Formation And Implications For South American Faunal Diversity., Brigid Erin Connelly
New Species Of Dryolestoid From The Late Cretaceous Allen Formation And Implications For South American Faunal Diversity., Brigid Erin Connelly
Electronic Theses and Dissertations
Dryolestoids are extinct cladotherians mammals from the Jurassic and Cretaceous periods. I describe a collection of dryolestoid specimens from the Late Cretaceous localities of Cerro Tortuga (Allen Formation), Anfiteatro 1, and Shining (both La Colonia Formation) from Patagonia, Argentina. Using comparative morphology, I identify a new species of meridiolestidan dryolestoid based on eleven specimens across both formations. The new species’ recovery from La Colonia Formation represents the first dryolestoid connection between the two approximately contemporaneous formations. The species’ morphology may represent an ecological shift within Meridiolestida from insectivory to herbivory, showing a transition in characters between the plesiomorphic sharp-toothed meridiolestidans …
Epitranscriptomic Regulation In Breast Cancer And Pcb-Induced Liver Disease., Belinda Petri
Epitranscriptomic Regulation In Breast Cancer And Pcb-Induced Liver Disease., Belinda Petri
Electronic Theses and Dissertations
Post-transcriptional RNA modifications including N6-methyladenosine (m6A) regulate mRNA stability, splicing, and translation. My research examined m6A in two disease models: breast cancer (BCa) and non-alcoholic fatty liver disease (NAFLD). Acquired resistance to endocrine therapies (ET) develops in approximately 20% of BCa patients with estrogen receptor α positive (ER+) tumors following treatment. The mechanisms by which tumor cells evade ET are not completely understood. Using a cell line model, we investigated the role of an m6A reader protein, HNRNPA2B1 (A2B1) that is upregulated in ET-resistant ER+ BCa cells. Stable overexpression of A2B1 in ET-sensitive MCF-7 cells (MCF-7-A2B1), results in ET resistance, …
Teachers And Administrators' Perceptions Of The Implementation Of District Student Conduct Procedures., Amy Ghibaudy
Teachers And Administrators' Perceptions Of The Implementation Of District Student Conduct Procedures., Amy Ghibaudy
Electronic Theses and Dissertations
While there is a body of research about student conduct policies and procedures, there is a lack of research about how different role groups work together to implement these procedures and have a positive working interpersonal relationship. This sequential mixed methods case study design takes place in a large urban school district. In this study, I investigate the perceptions that educators have on the implementation of student conduct procedures in their school. I also explore how their perceptions of each other shape their interpersonal relationships. I used Normalization Process Theory (NPT) as my guiding theoretical framework. This study drew upon …
The Influence Of Power On Racial Identity And Social Power: Learning While A Minority In A Bullitt County High School In Kentucky., Michele Johnson
The Influence Of Power On Racial Identity And Social Power: Learning While A Minority In A Bullitt County High School In Kentucky., Michele Johnson
Electronic Theses and Dissertations
The purpose of this phenomenological study is to examine the influence of power on racial identity and social awareness of minority high schools’ students in Bullitt County, Kentucky. The research will come from the student perspective of those attending high school with students predominantly from another racial background. Using purposeful sampling, 12 students participated in semi-structured interviews, providing insight into three research questions regarding racial identity, social power, and social awareness. Student participants used their voice to share their lived educational experiences attending school with students from another racial background. Interviews were transcribed, coded and analyzed using In Vivo and …
Promotional Communication For A College Food Pantry: Findings From A Cross-Sectional Assessment Of Socioecological Variables Related To Past Use Of A Campus-Based Food Pantry., Bunny Marie Hayes
Electronic Theses and Dissertations
Objective: This study examined differences between users and non-users of campus food pantry, conducted communication audit, and made recommendations for future food pantry communication. Methods: Cross-sectional twofold study, first analyzing existing intrapersonal, interpersonal, and environmental data to test predictors of campus food pantry usage characteristics, using inferential statistics. Secondly, conducting a communication audit that evaluates the reach of student communication. Results: Significant differences were found between users and non-users of food pantry that support hypotheses in relation to gender, age, race, class, marital status, housing type, housing description, and Pell eligibility. Findings could not support hypothesized differences in first-generation status. …
Non-Western Rendition Of Ambient Rhetoric Of Khajuraho Monuments., Shiva Hari Mainaly
Non-Western Rendition Of Ambient Rhetoric Of Khajuraho Monuments., Shiva Hari Mainaly
Electronic Theses and Dissertations
This dissertation develops an ambient rhetoric: a living practice that is more disclosive than communicative, more entangled than intersectional, and more subtle than explicit and evidential. Rather than exploring the symbology, iconography, texture, and artistic integrity of Khajuraho monuments, I claim that Khajuraho monuments aim at convincing visitors with their persuadability and affectability inherent in their material bases, architectural panels, fractal design, allegorical cast, aura of attunement, and the environment in which the monument complex is nestled. Khajuraho groups of monuments in Central India, matchless in their monumentality, dynamic in their adjustment to the shifting socio-politico-cultural landscape in the world, …
Incidence And Determinants Of Hypertensive Disorders Of Pregnancy In The Us: Hospitalization Discharge Rate For Preeclampsia, Eclampsia, And Gestational Hypertensions, 2016-2018., Kahir S. Jawad
Electronic Theses and Dissertations
Background: Hypertension remains one of the most prevalent medical issues in pregnancy. It contributes considerably to maternal and fetal morbidity and mortality, making it one of the most significant public health problems. Although various epidemiological studies have been conducted over the past decades to assess the disease incidence and key risk factors associated with hypertensive disorders of pregnancy, current incidence rates and trends are lacking. This is a novel and significant study because there are no current population-based incidence estimates of hypertensive disorders of pregnancy and their subtypes and very few studies with the power to explore a wide range …