Digital Commons Network^™

Factors Affecting Nurse Educators' Decision To Teach., Linda J. Thomas 1946-

Electronic Theses and Dissertations

The field of nursing currently faces a shortage of both nurses and nursing faculty. Yet, little is known about why clinical nurses opt to become nursing faculty. Qualitative investigations into this phenomenon are particularly rare. This study addressed these gaps in the context of career choice of faculty associate degree nursing (ADN) programs. The qualitative analysis was guided by Astin's (1984) psychosocial model of career choice. The central research question was, "What factors influence the career choice of nurse educators currently teaching in Kentucky associated degree nursing programs?" Faculty from the 20 ADN programs in public community colleges and 4-year …

Social-Cognitive Predictors Of Physical Activity Initiation In Type 2 Diabetes Following Diabetes Self-Management Education : Application Of The Health Action Process Approach., Jason E. Bonner

Electronic Theses and Dissertations

Type 2 diabetes presents a public health crisis and a global pandemic. Successful management of diabetes requires engagement in a daily regimen of self-care behaviors to achieve optimal glycemic control and to reduce the severity of diabetes-related complications. Regular engagement in physical activity has been demonstrated to improve glycemic control and overall quality of life among patients with diabetes. Diabetes self-management education (DSME) has become the hallmark for instructing patients with diabetes to engage in physical activity, yet physical activity patterns of DSME patients remains largely unknown. Further, it is unclear what factors could account for such behavior change in …

Determination Of Variables Which Predict Success On The National Council Licensure Examination (Nclex-Pn)., Mary A. Kleber

Electronic Theses and Dissertations

Nursing is one of the most frequently chosen programs by those entering postsecondary institutions in preparation for a career. This is in part due to the job opportunities available, interest in healthcare, and a pending shortage of nurses in healthcare. One strategy for meeting this shortage is the career pathway which encompasses the concept of lifelong learning and provides a mechanism for advancement of nurses along a continuum. Regardless of the level that a student enters the nursing education continuum, failure on the national licensure exam becomes a burden to both graduates and faculty in time and resources expended. Whereas …

The Role Of Genetic And Environmental Oxidative Stress Factors In Prostate Cancer., Nicole A. Lavender

Electronic Theses and Dissertations

Prostate cancer (PCA) development may be influenced by genetic variations within oxidative stress response (OSR) related mechanisms, such as antioxidation (e.g., carcinogen metabolism/detoxification), DNA repair, and apoptotic regulation. Excessive oxidative stress can produce DNA base changes, damage tumor suppressors, enhance proto-oncogene expression, and induce malignant transformation of cells. Persistent oxidative stress may even trigger apoptosis. Environmental reactive oxygen species (ROS) exposure attributable to lifestyle factors may exacerbate this situation by increasing oxidative stress. Therefore, it is likely that genetic variation resulting in compromised ROS capacity combined with increased environmental ROS exposure may increase PCA risk and disease aggressiveness. Consequently, this …

Role Of Sabp2 In Systemic Acquired Resistance Induced By Acibenzolar-S-Methyl In Plants., Diwaker Tripathi

Electronic Theses and Dissertations

Plants have evolved an efficient mechanism to defend themselves against pathogens. Many biotic and abiotic agents have been shown to induce defense mechanism in plants. Acibenzolar-S-Methyl (ASM) is a commercially available chemical inducer of local and systemic resistance (SAR) response in plants. ASM functioning at molecular level is mostly unclear. This research was designed to investigate the mechanism of ASM action in plants. It was hypothesized that SABP2, a plant protein, plays an important role in ASM-mediated defense signaling. Biochemical studies were performed to test the interaction between SABP2 and ASM. Transgenic SABP2-silenced tobacco plants were used to determine the …

Rural Versus Urban: Tennessee Health Administrators' Strategies On Recruitment And Retention For Allied Health Professionals., Derek Ray Slagle

Electronic Theses and Dissertations

There is a growing interest in understanding recruitment, retention, and turnover of allied health professionals considering employment trends and workforce mobility, an increased need to understand the healthcare delivery system, and the dynamic nature of the allied health workforce especially for rural areas. A survey was sent to allied health administrators across a variety of allied health disciplines from the state of Tennessee hospitals in order to gauge opinions on retention and recruitment strategies. Overall successful strategies for recruitment and retention of allied health professionals were reported as well as differences between urban and rural areas, differences among allied health …

"Knowing Where I Am At": The Experience Of Self-Monitoring Blood Glucose For People With Non-Insulin-Requiring Type 2 Diabetes., Dana Elisabeth Brackney

Electronic Theses and Dissertations

Eleven participants living with non-insulin-requiring Type 2 Diabetes (T2DM) discussed their self-monitoring blood glucose (SMBG) experience. All had been recently diagnosed (< 2 years) and treated for diabetes with a self-regulating SMBG guideline for primary care practice. Their digitally-recorded interviews and photographed logbooks were analyzed thematically and interpreted through the lens of numeracy literature to answer 2 questions: 1. What is the meaning of SMBG among people with non-insulinrequiring T2DM? 2. How do people with non-insulin-requiring T2DM perceive the function of SMBG in diabetes self-management? The meanings of SMBG were patient competence, "It is easy, just a little pin prick"; patient control, "I can control it. It doesn't control me"; and patient security, "It is not that way anymore." Three periods of lived time were observed: Diagnosis "The numbers say I have diabetes"; "I just can't figure out why it does that"; and Routine "I make my numbers." Prominent numeracy functions emerged by time period. During Diagnosis primary numeracy functions included comparing SMBG results to target values. Participants expressed this experience as, "I am some kind of O.K." During applied numeracy functions included taking medication correctly. SMBG readings were experienced as a clue to the diabetes mystery, sometimes confusing the participants, "I just don't …

Family Income, Maternal Marital Status, Maternal Employment, And The Development Of Overweight And Obesity During Childhood., Shaoqing Gong

Electronic Theses and Dissertations

This study examined the longitudinal associations of family income level, maternal marital status, and maternal employment with body mass measurements and the development of overweight and obesity. Multiple linear and logistic regressions were used to assess the effects of the exposure variables on weight status with simultaneous adjustment for the exposure variables and the covariates. Key findings include: Children in families with incomes below the poverty line at child's 24 or 54 months of age were at a higher risk of becoming overweight and obese at child's third grade than children in families with incomes above the poverty line; longer …

Synthesis Of A Water Soluble Resveratrol Derivative As A Potential Anti-Cancer Drug., Augustine Essel

Electronic Theses and Dissertations

Research on development of water soluble anti-cancer drugs is one of the great challenges of modern medicinal chemistry. Resveratrol (Res) is one of the many phytoalexins producing stilbenoids present in several medicinal plants, grape skin, peanuts, and red wine. It has been found to exhibit anti-cancer, anti-inflammatory, and anti-oxidant properties. Water solubility and bioavailability are some of the setbacks of this interesting compound. In view of this, effort has been made to synthesize amino acid derivative of resveratrol to improve its bioavailability and solubility in water. Methyl 4-{-[(1E)-2-(3, 5-dihydroxyphenyl)-ethenyl] - phenoxy} butyrate (7), a novel ester intermediate, has been synthesized …

Risk And Protective Factors Associated With Academic Achievement Among Ghanaian Youth, Ziblim Abukari

Electronic Theses and Dissertations

Young people in Ghana who grow up in poverty and to families with little or no education endure limited early learning opportunities, underfunded educational systems, and more health and mental health problems compared to their peers from more privileged backgrounds. A significant body of literature addressing the relationship among risk, protection, resilience and academic achievement is based on youth populations in North America and Western Europe. Relatively little is known about the applicability of ecological and risk and resilience frameworks in non-Western countries. Consequently, educational outcomes of young people in Ghana are often characterized by similarities in low achievement, lack …

Systemic And Strength Effects : Experimental Concentrations Of Topical Menthol., Lee Jordan Winchester 1984-

Electronic Theses and Dissertations

Menthol has been regularly utilized as a treatment in sports related injuries for many years, yet little is known about its physiological interactions or its effect on performance. Our previous study indicates that topically applied menthol may cause an acute decrease in blood flow and may improve strength capabilities. The purpose of this study is to examine the effects of two different concentrations of menthol (3.5% and 10%) on systemic blood flow and strength. 16 subjects participated in this 4 week study examining blood flow and strength effects after menthol or control treatment. Results indicate that the 3.5% menthol causes …

The Role Of Hsl7 In Morphology And Pathogenicity And Its Interaction With Other Signaling Components In The Plant Pathogen Ustilago Maydis., Charles Ben Lovely 1977-

Electronic Theses and Dissertations

Dimorphism is a highly conserved process in fungi in which a transition between a unicellular, yeast-like growth form and either a unicellular or multicellular, filamentous growth form occurs in response to several different environmental cues. The phytopathogenic fungus Usti/ago maydis undergoes the dimorphic transition from a yeast-like saprobic growth form to a unicellular, hyphal growth form in response to successful mating and subsequent host cues. In addition, U maydis can also undergo haploid filament formation in response to several environmental cues including low ammonium conditions and growth in lipids or acid pH. On solid media deficient in ammonium (SLAD), U …

Curcumin Reactivates Epigenetically Silenced Tumor Suppressor Gene Tissue Factor Pathway Inhibitor-2 In Hepatocellular Carcinoma Cells., Akshata Moghe 1983-

Electronic Theses and Dissertations

Hepatocellular carcinoma (HCC) is the fifth most common cancer worldwide and the third most fatal, with a rising incidence in the US as a result of the increase in alcoholic liver disease and obesity. Current therapeutic strategies are unsatisfactory with poor treatment outcomes and efficacious therapies are acutely needed for better management of this deadly disease. Curcumin, a phenolic compound from the rhizome of the plant Curcuma longa has been shown to inhibit growth and induce cell death in various types of cancer cells including HCC. However, the anti-HCC mode of action of curcumin has not yet been elucidated. In …

Design, Fabrication, And Testing Of A Microfluidic System For Cardiac Cell Culture., Mai-Dung Thi Nguyen

Electronic Theses and Dissertations

Cardiovascular disease (CVD) is the leading cause of death in the United States and accounts for nearly 1,372,000 deaths each year. In addition, ~81 million Americans suffer from some form of CVD. Understanding the molecular basis of various manifestations of CVD requires cellular-level studies. However, current technologies for cell culture, fail to recreate the in-vivo environment where cells are subject to pressure and stretch as a consequence of normal hemodynamic loading and unloading. Therefore, to study cardiac cells with physiological relevance, the mechanical loading environment needs to be accurately replicated in-vitro. In order to create an appropriate platform for cardiac …

The Role Of Matrix Metalloproteinases Induced Angiogenesis During Transition From Compensatory Cardiac Hypertrophy To Cardiac Failure : Therapeutic Effects Of Hydrogen Sulfide., Srikanth Givvimani

Electronic Theses and Dissertations

Background: Although matrix metalloproteinase (MMPs) and tissue inhibitor of metalloproteinase (TIMPs) play a vital role in tumor angiogenesis and TIMP-3 causes apoptosis, their role in cardiac angiogenesis is unknown. Interestingly, a disruption of coordinated cardiac hypertrophy and angiogenesis contributes to the transition to heart failure, however, the proteolytic and anti-angiogenic mechanisms of transition from compensatory hypertrophy to decompensatory heart failure are unclear. Previous studies have shown the cardio protective role of hydrogen sulfide (H2S) in myocardial ischemia, infarction and heart failure, but its role during transition from compensatory cardiac hypertrophy to heart failure is yet to be unveiled. We hypothesize …

The Impact Of Parental Risk Factors On Child Outcomes : Examining Parental Incarceration Within A Multiple-Risk Model., Melody Lynn Hyppolite 1976-

Electronic Theses and Dissertations

The impact of four primary parental risk factors (parental mental illness, parental substance use, parental mental illness, and poverty) on seven child outcomes (school failure, criminal behaviors, being arrested, behavioral difficulties, emotional difficulties, alcohol, and drug use) was examined. The accumulation of multiple risk factors in a child's life was found to significantly increase the likelihood that several negative outcomes would occur. The research, however, suggests further that this is an over simplification of the phenomenon and that specific risk factors are more likely to contribute to specific child outcomes. Depending on the outcome being addressed by programming and policies …

Resistance Training Increases The Expression Of Ampk, Mtor, And Glut4 In Previously Sedentary Subjects And Subjects With The Metabolic Syndrome., Andrew Steven Layne

Electronic Theses and Dissertations

Exercise has been considered a cornerstone of diabetes prevention and treatment for decades, but the benefits of resistance training are less clear. Nineteen non-diabetic subjects (10 metabolic syndrome, 9 sedentary controls) underwent 8 weeks of supervised resistance training. After training, strength and V̇ O_2max increased by 10% in both groups. Percent body fat decreased in subjects with the metabolic syndrome. Additionally, lean body mass increased in both groups (p<0.05). Expression of glucose transporter protein-4 (GLUT4), the principle insulin-responsive glucose transporter, increased significantly in both groups. 5-adenosine monophosphateactivated protein kinase (AMPK) and mammalian target of rapamycin (mTOR) expression increased in both groups, indicating increased protein synthesis and mitochondrial biogenesis. Markers of insulin resistance measured by a euglycemic hyperinsulinemic clamp did not improve in subjects with the metabolic syndrome but increased significantly in control subjects (13%). Resistance training upregulates intracellular signaling pathways that may be beneficial for ameliorating the metabolic syndrome.

The Effects Of An Actiped Pedometer Intervention Program On Body Composition And Aerobic Capacity Of Youth In A School System In East Tennessee., Kristie Russell Coleman

Electronic Theses and Dissertations

The purpose of this study is to determine if the ActiPed Pedometer Intervention Program would sustain or improve aerobic capacity or body composition scores over a 12-week period for students ages 8-12 in a school system in East Tennessee. Obesity is an epidemic in Tennessee and in the United States. In fact, Tennessee has the 5^th highest obesity rates for youth in the United States. National and State Legislations with physical activity and wellness mandates are being passed at an alarming rate as the need to combat the obesity epidemic is astonishing. The responsibility to decrease the obesity rates …

Inhibition Of Escherichia Coli Atp Synthase By Polyphenols And Their Derivatives., Prasanna Keerthi Dadi

Electronic Theses and Dissertations

We have studied the inhibitory effect of natural and structurally modified polyphenols on Escherichia coli ATP synthase to test (I) if the beneficial dietary effects of polyphenols are related to their inhibitory actions on ATP synthase, (II) if inhibitory effects of polyphenolic compound could be augmented through structural modifications, and (III) if they can act as antimicrobial agent through their actions on ATP synthesis. X-ray crystal structures of polyphenol binding sites suggested that polyphenols bind at a distinct polyphenol binding pocket, at the interface of α,β,γ-subunits. We found that both natural and modified polyphenols inhibit E. coli ATP synthase to …

Assessing Commercial Organic And Conventionally Grown Vegetables By Monitoring Selected Heavy Metals Found In Them., Charles Kafui Dotse

Electronic Theses and Dissertations

Commercially available organic and conventionally grown vegetables were studied by quantitative determination of selected metals in them and to determine if any differences found are statistically significant. These findings can help the consumers to determine if the vegetable products are within the recommended maximum limits as proposed by the joint FAO/WHO Expert committee on organic foods designation. Eight edible vegetables were purchased from local stores in both the organic and conventionally grown categories. Samples were digested with concentrated nitric acid and the metals monitored were zinc, copper, lead, iron, cadmium, and nickel using flame atomic absorption. The concentration range for …

At-Risk Indicators: The Impact On School Success., Lisa Wynn Stewart

Electronic Theses and Dissertations

The hope of educators is that children will obtain a strong educational foundation that will lead to life-long learning and a bright future. However, several factors may play a role in hindering a successful outcome. Addressing the at-risk indicators of excessive absences, discipline referrals, socioeconomic status, disability status, early grade retention, and family composition gives insight into struggles students face.

Looking at 6 research questions, an independent sample t test was used to determine the difference in students who had excessive absences and discipline referrals in relation to school success. A chi-square analysis was used to identify the relationship between …

Predictors Of Depression In African American Men And Their Implications For Community And Individual Focused Interventions., Michael A. Robinson

Electronic Theses and Dissertations

Background: In any given year depression affects as many as 121 million people worldwide and 20 percent or 19 million people in the U.S. suffer from at least one episode of depression during their lifetime. In the U.S., depression has a substantial impact on the economy. It is estimated that $17 billion dollars in salary and/or equivalent compensation is lost due to missing work days, caused by major depression. Depression is considered a highly prevalent condition that can lead to significant functional impairments, such as absenteeism and work productivity and problems with activities of daily living. This study focuses on …

Predictors Of Risk For Child Neglect Among Expectant First-Time Mothers And Their Partners., Bertha M. Mucherera

Electronic Theses and Dissertations

The study purpose was three-fold: finding a point of entry for primary prevention of child neglect, assessing for child neglect risk level for both first-time mothers and their partners, and individuals opinions about establishing and administering a multi-dimensional family assessment tool prior to birth. This study utilized a non-experimental, cross-sectional design to survey 250 first-time expectant mothers and their partners, attending Lamaze Classes at a public hospital in Lexington, Kentucky. Participants completed a 97-item questionnaire comprised of eleven different measures identifying individual personal (Attachment Theory) and situational characteristics (Ecological Theory). Results indicated that this particular population was predominately White Caucasian …

Health Promotion Self-Efficacy Of Belizean Nurses : Variables Influencing Condom Use Promotion To Women To Prevent Hiv/Aids., Whitney A. Nash

Electronic Theses and Dissertations

This dissertation is a descriptive, correlational study that explores how a nurse's personal sexual relationship power, vicarious experience, and other interpersonal and socio-cultural variables are related to her self-efficacy to promote and teach condom use to women to reduce the risk of contracting HIV/AIDS. How these variables are related among a specific subset of nurses with lower sexual relationship power is also examined. Self-efficacy theory, specifically portions of Dr. Albert Bandura's work is used to guide this exploration. Chapter 1 introduces the problem of HIV/AIDS in Belize; the role of power, and selected issues surrounding women and HIV/AIDS. Chapter 1 …

Examining The Dissemination Of Innovations In The Sporting Goods Industry., Marion E. Hambrick

Electronic Theses and Dissertations

US consumers spend $87 million annually on sporting goods and services (National Sporting Goods Association, 2008). Each year sporting goods manufacturers also spend millions of dollars creating innovative products for consumers looking to improve their playing performances and enjoyment of the sport (Reisinger, 2002). Manufacturers want to receive adequate returns on their research and development investments and create innovations consumers support and want to buy (Berman & McLaughlin, 1973). To facilitate the dissemination of innovations, manufacturers provide information about their innovations to increase product awareness and help consumers make informed purchasing decisions (Rogers, 2003). The purpose of the current study …

A Descriptive-Comparative Study Of Professional Development And Observed Quality In Early Care And Education Programs, Rebecca Romeyn

Electronic Theses and Dissertations

With over 12 million children enrolled in early care and education programming across the U.S., families with children under the age of 5 years old are dependent on these programs. Although highly important, little regulation exists regarding qualifications necessary for individuals to work in these programs. Consequently, individuals in the field bring a plethora of professional development experiences, skills, and competencies. This variance is partly a result of the uncertainty surrounding what should be required. Major information about the impact training and education have on these programs is missing from quantitative research, including capturing content and quantity, accurate measurement of …

A Grounded Theoretical Approach To Embodiment Among Homeless Youth, Felicia Washington Sy

Electronic Theses and Dissertations

Using grounded theory methodology, this research explored, described and theorized about the ways youth, specifically homeless youth; make sense of their bodies within the context of living environments. It describes the relationship between body, space, and context for homeless youth in order to inform treatment options for this population. The importance of context, setting, and participant frame of reference was stressed, because embodiment is contextually and culturally influenced. The research addressed the questions: What is the process of becoming consciously embodied for homeless youth who have experienced multiple traumas? Do homeless youth who have experienced multiple traumas perceive a role …

Classical And Nonclassical Antifolates: Synthesis Of Furo-[2,3-D] Pyrimidines Pyrrolo[2,3-D]Pyrimidines And Pyrimido-[4, 5-B]-Indoles, Lei Wang

Electronic Theses and Dissertations

The dissertation will give an introduction, background and our research progress in the areas of antifolates. The design and synthesis of both classical and nonclassical bicyclic furo[2,3-d]pyrimidines, pyrrolo[2,3-d]pyrimidines and tricyclic pyrimido[4,5-b]indoles as potential antifolates have been described. As a part of this study, a total of one hundred and fifty-three new compounds have been synthesized and characterized. Of these, sixty-seven final compounds were submitted for biological evaluation.

Mothers Behind Bars: The Lived Experience, Annette Weiss

Electronic Theses and Dissertations

Purpose

Few research studies have been conducted by nurses that focus on incarcerated women. In fact, there are a limited number of research studies with a focus on the incarcerated female by any individual group of health professionals. The purpose of this qualitative study was to explore the lived experience of the incarcerated woman as a mother, and to obtain an increased understanding of the meaning of her experience.

Background

The United States has the highest per capita rate of incarcerated persons of all countries. Women are the fastest growing group of inmates and are being incarcerated at double the …

Social Capital Influences In Women At Risk For Poor Pregnancy Outcomes, Jennifer James-Mesloh

Electronic Theses and Dissertations

Poor pregnancy outcomes such as prematurity, low birth weight and infant mortality are societal indicators of a nation’s health status. These indicators have remained at exceptionally high rates in the United States despite the levels of resources and technology. In the quest to understand that discrepancy, among the ranges of theories and models for explaining poor pregnancy outcomes an emerging concept is coming to attention: social capital. In order to test whether maternal social capital has an impact on pregnancy outcome, women in a Healthy Start program were surveyed over a 13-month period to assess their social capital levels and …