Digital Commons Network^™

Detecting Evidence Of Systemic Inflammation From Osteological Markers In The Indian Knoll Population Of Ohio County, Kentucky., Krysta Wilham

Electronic Theses and Dissertations

Indian Knoll is an Archaic shell midden site located in the Green River region of west-central Kentucky, and was excavated twice in the first half of the 20^th century. While Indian Knoll has been the subject of frequent bioarchaeological studies, the present study presents an osteological analysis of the relationships between skeletal markers commonly associated with local inflammatory processes, and that have the potential to be used as proxies for systemic inflammation. The analysis revealed a significant positive association in the presence of periodontal disease (PD) and periosteal lesions (PL), suggesting a potential underlying hyper-inflammatory status or phenotype. These …

Cost Of Care For Hospitalized Patients With Pulmonary Mycobacterial Diseases In The United States., Mary Beth Wells Allen

Electronic Theses and Dissertations

Background: Pulmonary mycobacterial diseases describe both tuberculosis (TB) and nontuberculous mycobacteria (NTM). Few data are available measuring the cost burden of mycobacterial diseases on the national level. The purpose of this study was to evaluate the cost burden and measure emerging trends in hospitalization of pulmonary TB and NTM in the US from 2001 through 2012. Methods: This study was a retrospective community based cost analysis of hospitalized patients with a principal diagnosis of pulmonary mycobacterial diseases from 2001 through 2012. Data for pulmonary TB and NTM were retrieved from the Healthcare Cost and Utilization Project (HCUP), US Department of …

Tnf-Like Weak Inducer Of Apoptosis (Tweak) : Not So Weak After All., Joseph Dekward Mcmillan Iv

Electronic Theses and Dissertations

Background: Tumor necrosis factor (TNF)-like weak inducer of apoptosis (TWEAK) is a proinflammatory cytokine belonging to the TNF super family. TWEAK produces a variety of cellular responses through the binding to fibroblast growth factor inducible 14 (Fn14), a member of TNF receptor superfamily. Although Fn14 lacks a death domain, TWEAK has been found to induce apoptosis in some cell types by perturbing the activity of certain pathways such as TNF-receptor signaling. TWEAK is also known to regulate proliferation and differentiation of myogenic cells. We have previously reported that the TWEAK-Fn14 system causes skeletal muscle wasting both in vitro and in …

Leadership Practices Of Supervisory Employees: An Exploration Of Current Practices At A Southeastern Veterans Affairs Medical Center, Melissa M. Zimmerman

Electronic Theses and Dissertations

As the nation’s healthcare system moves through the 21^st century, unprecedented changes are occurring on both a local and global stage. Healthcare organizations are faced with creating and implementing leadership strategies to enhance the overall patient experience. When coupled with the need to ensure increased nurse job satisfaction, improved cost-effectiveness and healthy organizational cultures with fiscally sound budgets, improvement work has led efforts to ensure effective leadership techniques are used across an agency.

This task may be viewed as commonplace for some organizations, while others may perceive this process as a complete paradigm shift from historical practices related to …

Pharmacokinetics, Tissue Distribution, Synergistic Activity, And Antitumor Activity Of Two Isomeric Flavones, Crystal L. Whitted

Electronic Theses and Dissertations

Flavonoids are polyphenolic secondary metabolites found in plants that have bioactive properties including antiviral, antioxidant, and anticancer. Two isomeric flavone were extracted from Gnaphalium elegans and Achyrocline bogotensis, plants used by the people from the Andean region of South America as remedies for cancer. 5,7-dihydroxy-3,6,8-trimethoxy-2-phenyl-4H-chromen-4-one (5, 7–dihydroxy- 3, 6, 8 trimethoxy flavone/ flavone A) and 3,5-dihydroxy-6,7,8-trimethoxy-2-phenyl-4H-chromen-4-one (3, 5–dihydroxy-6, 7, 8–trimethoxy flavone/ flavone B) have shown antineoplastic activity against colon cancer cell lines dependent upon their differentiation status. Pharmacokinetic studies reported herein were used to determine dosing for antitumor assays, as well as determine target tissue concentration. These included the …

Mid-Level Dental Care Provider: Awareness And Attitudes Of Ohio’S Dental Hygienists, Cynthia S. Leverich

Electronic Theses and Dissertations

The purpose of this study was to determine the awareness and attitudes of dental hygienists in Ohio regarding the Advanced Dental Hygiene Practitioner (ADHP) as an occupation proposed by the American Dental Hygienists’ Association and to determine whether the ADHP could be a viable career option for Ohio dental hygienists.

I developed a survey to assess dental hygienists’ awareness, attitudes, and their views regarding the new mid-level dental provider. The study was limited to licensed dental hygienists in Ohio. The study included a simple random sample of 400 of the 4100 dental hygienists in Ohio obtained by a systematic approach, …

A Study Of The Perceptions Of Racial Equity In One Early Childhood Education Program, Dawn M. Meskil

Electronic Theses and Dissertations

Although public education in the United States has had remarkable growth and improvement since its beginning, significant inadequacies concerning racial equity continue to cast a shadow on the system. Despite desegregation efforts and specific attention to providing integrated school settings there has been little progress in establishing educational justice. The purpose of this case study was to uncover perceptions about racial inequity within Asheville City Schools as well as potential facilitators of equity. A qualitative case study using 10 guiding research questions was conducted to evaluate the perceptions of parents as well as educators at Asheville City Schools Preschool regarding …

Self-Perceived Coordinated School Health Coordinator Leadership Styles And Practices, Heather R. Ledbetter

Electronic Theses and Dissertations

School-aged children’s health needs have changed over the last several decades to the present day population of many overweight and obese children with health complications (Centers for Disease Control & Prevention, 2015). Tennessee has implemented the Centers for Disease Control and Prevention’s (CDC) model for Coordinated School Health (CSH) in all public schools. Leading each school district’s program is a CSH Coordinator. The role of CSH Coordinators is to provide leadership to district and school administrators while effectively and efficiently implementing the CSH program (Wechsler, 2012).

The purpose of this quantitative study was to explore the self-perceived leadership styles and …

Restoring Relationship: How The Methodologies Of Wangari Maathai And The Green Belt Movement In Post-Colonial Kenya Achieve Environmental Healing And Women's Empowerment, Casey L. Wagner

Electronic Theses and Dissertations

The effects of the colonial project in Kenya created multi-faceted damages to the land and indigenous people-groups. Using the lens of ecofeminism, this study examines the undergirding structures that produce systems such as colonization that oppress and destroy land, people, and other beings. By highlighting the experience of the Kikuyu people within the Kenyan colonial program, the innovative and ingenious response of Wangari Maathai's Green Belt Movement proves to be a relevant and effective counter to women's disempowerment and environmental devastation in a post-colonial nation. The approach of the Green Belt Movement offers a unique and accessible method for empowering …

Residual Feed Intake And The Relationship With Performance, Temperament And Carcass Traits In Growing And Finishing Steers, Courtney R. Branton

Electronic Theses and Dissertations

Two trials were conducted with Santa Gertrudis steers, trial 1 (n = 115) and trial 2 (n = 118), were fed a roughage-based diet during the growing phase and high-grain diet during the finishing phase. Steers were weighed at 14-d intervals and dry matter intake (DMI) measured for 70 d during both phases. Residual feed intake (RFI) is the difference between actual DMI and DMI predicted from linear regression of DMI on mid-test metabolic body weight. Ultrasound carcass measurements were measured on day 0 and 70 of the growing phase. Steers were harvested after finishing phase and carcass cooler traits …

Perceptual Variations In Thermoregulation During Exercise In A Hot Environment, William C. Alger

Electronic Theses and Dissertations

ABSTRACT

Professionals are seeking to find ways to prevent exertional heat illness (EHI) in populations working in hot environments as well as populations that are physically active. The purpose of the present study was to evaluate individuals’ ability to accurately perceive core temperature ranges associated with homeothermic and EHI temperatures during exercise. Ten physically active males exercised on a treadmill at a self-selected rate until core temperature reached 39°C. Participants rated perceived core and skin temperature on 100 mm scales each time core temperature increased 0.25˚ C (37.5-39.0˚ C), along with thermal comfort and sweating sensation. During exercise core temperature …

Breeding Season Avian Community Composition And Prey Availability In Eucalyptus And Slash Pine Plantations Of Southwestern Louisiana, Elizabeth J. Messick

Electronic Theses and Dissertations

The increased demand for wood products related to industries such as bioenergy and paper has resulted in a need for a consistent supply of raw materials. Eucalyptus (Eucalyptus spp.) plantations have the potential to boost wood production for pulpwood and biomass feedstocks. Species characteristics such as rapid, indeterminate growth, coppice regrowth, resistance to disease and insects, and tolerance of a range of environmental conditions make these species successful short-rotation woody crops (SRWCs). Camden white gum (Eucalyptus benthamii), a more cold tolerant species, has made management of eucalyptus plantations viable in southern portions of the United States such …

Type 2 Diabetes Mellitus (T2dm) Onset And "Remission"., Srikanth Tangelloju

Electronic Theses and Dissertations

Background: Type 2 diabetes mellitus (T2DM) is a progressive disease condition. As the disease progresses the function of beta (β) cells (cells which regulate insulin) decline, thereby increasing the circulating blood glucose levels. If left unmanaged the disease progresses from onset to development of T2DM related complications and eventually death. When managed, in certain individuals, T2DM onset can be prevented and/or slowed down and in certain T2DM individuals, remission is observed. There are some known modifiable risk factors such as diet and physical activities that are associated with the speed and direction of progression, but much is still unknown. In …

Vinyl Chloride-Diet Interactions In Liver Disease : Potential Roles Of Autophagy And Energy Management., Anna L. Lang

Electronic Theses and Dissertations

Vinyl chloride (VC) is a prevalent environmental toxicant that has been shown to cause liver injury at high, occupational exposures. However, most studies have not addressed interactions of low doses with risk-modifying factors. This study aims to explore low-level VC metabolite exposure interactions with other potential risk-modifying factors and their effect on underlying liver disease. We examined sub-hepatotoxic effects of a VC metabolite (chloroethanol, CE) in two murine models of liver injury using ethanol and lipopolysaccharide (LPS). In both, CE significantly enhanced liver injury when compared to either ethanol or LPS alone. Previous studies have shown an increase in mTOR …

Toll-Like Receptor 4 Mutation Suppresses Hyperhomocysteinemia-Mediated Hypertension., Anastasia Familtseva

Electronic Theses and Dissertations

Background: Hyperhomocysteinemia (HHcy) has been observed to promote hypertension, but the mechanisms are unclear. Toll-like receptor 4 (TLR-4) is a cellular membrane protein that is ubiquitously expressed in all cell types of the vasculature. TLR-4 activation has been shown to promote inflammation that has been associated with pathogenesis of hypertension. In this study, we hypothesize that HHcy induces hypertension by TLR-4 activation that promotes inflammatory cytokine up-regulation (IL-1β, IL-6, TNF-α) and initiation of mitochondrial dysfunction leading to cell death and chronic vascular inflammation. Methods: To test this hypothesis, we used C57BL/6J mice (WT); Cystathionine-β-synthase deficient mice (CBS+/-) with genetic mild …

Rumination, Worry, And Drinking Behaviors In College Students : A Mediation Analysis., Stephanie Winkeljohn Black

Electronic Theses and Dissertations

Mental health and alcohol-related behaviors are constructs of concern on university campuses, as a significant portion of college students experience alcohol-related consequences. There is an established link between mental health variables, including repetitive thoughts associated with depression and anxiety, and drinking behaviors among college students. However, how preventative behaviors – protective behavioral strategies – impact the associations between repetitive thoughts and drinking behaviors and outcomes is less understood. The current longitudinal study analyzed mediational relationships among these variables in college students at a mid-sized 4-year university (N = 107; 78.5% female; average age = 21.06 years, SD = 4.41). Analyses …

Awareness, Perception, And Self-Reported Purchasing Behaviors Of College Students Regarding Front-Of-Package Nutrition Labeling Systems And Symbols, Audrey L. Kessler

Electronic Theses and Dissertations

Traditional students enroll in post-secondary institutions during emerging adulthood. College enrollment is increasing and adult weight gain occurs most rapidly during the college-age years, with poor food decisions as a potential contributing factor. The present study examined the awareness, perception, and self-reported purchasing behaviors of college students regarding four front-of-package (FOP) nutrition labeling systems and symbols. Students were sent a 24-question web-based survey, with 908 completed surveys that met the research criteria. There were 888 (98.3%) respondents who recognized at least one of the four presented FOP nutrition labels. There were no significant differences between the groups that recognized one …

Factors Influencing Healthy Eating And Physical Activity Behaviors Of Adolescents In Appalachia, Natalie Walker

Electronic Theses and Dissertations

This study examined the TPB constructs of attitude, perceived behavioral control, and subjective norms and their ability to predict healthy eating and physical activity behaviors among adolescents living in Southern Appalachia. The study also considered the relative utility of subjective norms and social support in predicting these behaviors. Data for this research were derived from a larger study, Team Up for Healthy Living, conducted September 2011 through November 2014 with high school students in the Appalachian region (Study ID: R01MD006200 from the National Institute on Minority Health and Health Disparities). Participants (n=963) completed a three-part paper survey collecting data about …

Improving The P300-Based Brain-Computer Interface By Examining The Role Of Psychological Factors On Performance, Samantha A. Sprague

Electronic Theses and Dissertations

The effects of neurodegenerative diseases such as amyotrophic-lateral sclerosis (ALS) eventually render those suffering from the illness unable to communicate, leaving their cognitive function relatively unharmed and causing them to be “locked-in” to their own body. With this primary function compromised there has been an increased need for assistive communication methods such as brain-computer interfaces (BCIs). Unlike several augmentative or alternative communication methods (AACs), BCIs do not require any muscular control, which makes this method ideal for people with ALS. The wealth of BCI research focuses mainly on increasing BCI performance through improving stimulus processing and manipulating paradigms. Recent research …

Social Comparison Processes As Contributors To Consistent Physical Activity., Holly M. Knight

Electronic Theses and Dissertations

The present study examined the impact that attention to social comparison (SC) information may have on consistency in physical activity (PA) behaviors across genders. SC factors, including SC frequency, SC direction and trait tendency to compare (SCO) were assessed within the Dynamic Relapse Model (DRM) as markers of PA consistency within men and women. Participants were N=200 individuals engaging in physical activity at YMCA gym facilities. Data collection utilized cross-sectional methods including anthropomorphic data collection at the point of recruitment and online selfreport measures post-recruitment. High adherence to regular physical activity was observed, with participants reporting infrequent slips in PA …

Effect Of A Recovery Supplement On Weight Lifting Performance, Muscle Fiber Morphology And Muscle Protein Accretion, Christopher B. Taber

Electronic Theses and Dissertations

The purposes of this dissertation were to examine the effect of a protein and carbohydrate recovery beverage versus a placebo on weightlifting performance, its effect on muscle morphological changes and specific muscle protein accretion. The following are major finding from the dissertation: 1) Protein and carbohydrate recovery supplementation does not appear to have influence on performance measure in trained weightlifters. This finding may be associated with the short-term nature of this study and the trained population used. 2) Compared with placebo, a protein and carbohydrate beverage provided greater benefits on cross sectional area of type I and type II muscle …

Exploring The Relationship Between Behaviour And Neurochemistry In The Polyphenic Spider, Anelosimus Studiosus (Araneae: Theridiidae), Jennifer B. Price

Electronic Theses and Dissertations

The importance of social behaviour is evident in human society, but there are both costs and benefits associated with cooperation and sociality throughout the animal kingdom. At what point do the benefits outweigh the costs, and when do selective pressures favour sociality and colonization over solitude and independence? To investigate these questions, we have focused on an anomalous species of spider, Anelosimus studiosus, also known now as the northern social spider. Throughout its broad range, A. studiosus is solitary and aggressive, but recently, colonies of cooperative and social individuals have been observed at northern latitudes. This leads to two …

The Combined Effects Of Leptin And Coenzyme Q10 In Ameliorating Obesity- Induced Infertility In Female Rats, Adekunle Adedeji

Electronic Theses and Dissertations

Infertility is one of the major problems of obesity. Studies have shown that administration of leptin reversed obesity-induced infertility in rats and mice. Coenzyme Q₁₀ (CoQ₁₀) is an antioxidant and also supplies the energy needed for ovulation and embryo development. We hypothesized that leptin when combined with CoQ₁₀ could greatly improve obesity-induced infertility. The results showed a significant decrease in food intake, body weight, and the regular estrous cycle was restored after treatment with leptin+CoQ₁₀. There was a significant increase (p10 significantly (p10 can improve fertility in obese infertile female rats. This study could …

The Church, State, And Literature Of Carolingian France, Steffan James Geiter

Electronic Theses and Dissertations

This thesis examines the eighth century rise in power of the Carolingian Church and the Carolingian dynasty through an early promise of religious revival, monarchial revival, and increased Papal power. Such aims gained the Carolingians a powerful in the Church. Aided by Boniface (672-754 AD) and the Church, the Carolingians replaced the Merovingians in Francia. In conjunction with this revival, Church scholars dictated a reformation of kingship in treatises called the Speculum Principum. A king’s position became tremulous when they strayed from these rules, as it betrayed their alliance. Ultimately, Louis the Pious (778-840 AD) faced deposition after they …

Dead Center: Polarization And The Democratic Party, 1932-2000, Colin S. Campbell

Electronic Theses and Dissertations

Polarization forced massive changes in the institutions of Washington throughout the 20^th century, and the Democratic Party played a key role throughout. Under President Franklin D. Roosevelt, the Democratic Party formed the powerful New Deal coalition. The coalition faltered in the turbulent 1960s under the pressures of the Vietnam War and racial unrest. The chaotic 1968 Democratic National Convention in Chicago dealt the coalition a mortal wound. Young voters and activists gained an outsized voice in the party. Several crushing defeats in presidential elections followed as the party chose unelectable candidates who appealed to the passions of left-wing activists …

Effects Of Acute Exercise On Postprandial Lipemia And Postprandial Glycemia, Stephen Decker

Electronic Theses and Dissertations

Introduction: Moderate-intensity aerobic exercise has been shown to attenuate the rise in triglycerides in during the postprandial period, however the effects of acute bouts of high-intensity exercise on postprandial lipemia and glycemia have not been explored. The purpose of this study was to examine the effects of acute high-intensity interval training on postprandial lipemia and postprandial glycemia.

Methods: Ten healthy males participated in a randomized crossover design consisting of one high-intensity exercise session and one sedentary control session, followed by consumption of a mixed meal. Blood triglyceride and glucose concentrations were monitored following the consumption of the meal.

Results: High-intensity …

Sensation Seeking And Conscientiousness In Relation To Caffeine Consumption And Expectancy, Cheyenne Bullock

Electronic Theses and Dissertations

Habitual caffeine consumers often report difficulty reducing caffeine use with many continuing to use caffeine despite experiencing symptoms suggestive of substance dependence. Given the evidence of a positive association between sensation seeking and substance use as well as initial reports of a negative relationship between elevated conscientiousness and substance use, this study proposed to evaluate the relationship of both factors on caffeine consumption and expectancy. Two hundred sixty-five students in an introductory psychology course completed a series of brief surveys assessing caffeine consumption, caffeine expectancies, sensation seeking, and conscientiousness. A statistically significant positive correlation was hypothesized for sensation seeking and …

Stop The Pricks: A Validation Study Of A Noninvasive Lactate Threshold Device, Rebecca M. Mcmorries

Electronic Theses and Dissertations

ABSTRACT

Purpose: The aim of this study is to assess the validity of a noninvasive lactate threshold device (NID) to determine lactate threshold heart rate (LTHR) and aerobic threshold heart rate (AeTHR).

Methods: Twenty-one recreational athletes completed a personalized graded exercise test on a treadmill. All participants wore the noninvasive device and blood lactate samples were taken at the end of 3-minute stages. Lactate threshold heart rate and aerobic threshold heart rate were then calculated using four traditional methods and compared against the same heart rate values calculated by the device.

Results: No significant differences were found in lactate threshold …

Comparison Of Two Body Weight Screenings Of Self-Conscious Emotions And Coping, Rachel N. Nanez Ms.

Electronic Theses and Dissertations

Novel technologies are currently being utilized in fitness and clinical settings. However, there is not much research to examine the emotional responses to such screenings.

PURPOSE: To examine the group differences between the FIT3D and DXA protocol on emotional responses and the differences between weight classifications.

METHODS: The Body and Appearance-related Self-conscious Emotions Scale and WEIGHTCOPE were used to assess self-conscious emotions and intention to utilize 10 different weight-related coping strategies following the scans. Motivation was measured by a 10-point Likert scale measuring motivation pre and post scans.

RESULTS: There were no differences in motivation, affective response, or intention to …

Optimism Bias In Fitness, Katrielle Marx

Electronic Theses and Dissertations

The people of the United States of America have been concerned with the population’s overweight and obesity rate for a while. The purpose of this study was to find out if optimism bias had an influence on fitness. Optimism bias is overestimating the likelihood of positive events and underestimate the likelihood of negative events happening in one’s life. This study created a fitness optimism scale and used a set of fitness assessments and exercise questions to correlate with the fitness optimism bias. There were 105 students who participated in this study, 82 females and 23 males with a mean age …