Digital Commons Network^™

Trace Element Analysis Of Human Dentition From The Elite Meroitic Cemetery At Sedeinga, Sudan To Determine Dietary Consumption And Cultural Behaviors, Tiffany Lee

Electronic Theses and Dissertations

Minimal research has been conducted on the human skeletal remains from this site, and this research is aimed toward adding knowledge of the Nubian culture for the period between the 1st c. AD to the 4th c. AD, particularly focusing on answering the following questions: 1) Was intra- individual variation present in dietary consumption or cultural behaviors based on elements found within an individual's multiple molars after analysis; 2) Was an inter-individual variation apparent, based on developmental age through permanent molars, that indicated a distinction between dietary consumption against all individuals; and 3) Based on known medicinal and cosmetic use …

School Library Access As Related To Student Reading Comprehension In An Urban East Tennessee School District, Lori Church

Electronic Theses and Dissertations

The purpose of this study was to explore the impact of school library access on student reading comprehension as measured by the Easy CBM universal screener test. The population consisted of 5^th and 6^th grade students enrolled in one intermediate school in an urban school system in East Tennessee. Data were analyzed for the population of the 2016-2017 academic school year. Specifically, this study considered the impact of school library access on students who qualify for free or reduced meals.

A quantitative study was used to find correlations and differences in the reading comprehension data and library checkout …

Novel Relative Spontaneous Ignition Temperature Determination Using Carbon Dioxide Onset With Sta/Ir, Antonio David Trevino

Electronic Theses and Dissertations

Simultaneous thermal analysis, coupled with infrared spectroscopy (STA/IR), was utilized to monitor the evolution of gaseous products during the thermal degradation of samples from Triadica sebifera (Chinese tallow), Ligustrum sinense (Chinese privet), and Ilex vomitoria (yaupon) plants. Identification of carbon dioxide was successful with a spectral match of 90.2 percent and further used in the determination of relative spontaneous ignition temperature, or RSIT. The RSIT value during the growing season for Chinese tallow, Chinese tallow stem, Chinese privet, and Yaupon were 208.4°C, 250.3°C, 210.1°C, and 232.3°C respectively. During the dormant seasons, the values for Chinese tallow stem, Chinese privet, and …

Bridging The Gap: Community Gardens As A Supplement To Senior Adult Food Assistance Programs, Jheri-Lynn Mcswain

Electronic Theses and Dissertations

Food insecurity and access to nutrition-rich food for senior adults receiving food assistance is an ever-growing concern in the United States. For households that lack accessible food, the availability of alternative sources of nutrition such as community gardens could be critically important to maintaining a stable level of food security. The purpose of this study was to explore the feasibility of using a community garden as a supplemental food assistance tool for congregate meals sites and food pantries. This study encompassed the following three phases: 1) surveying the trends in Shelby County, Texas senior adults receiving food assistance to determine …

An Examination Of The Impact That Communities In Schools' Interventions Make On High School Academic Performance, Coleton Cooper Dean Spruill

Electronic Theses and Dissertations

The following study seeks to answer the question: What impact does a local Communities In Schools (CIS), a nationwide dropout prevention program, affiliate's interventions have on a high school student's academic performance, absenteeism, and completion rates? To do this, the study examines the grade point average, absenteeism rate, and completion rate of 1298 students across four years of existing data from a local school district. For comparison purposes, the study uses a quasi-experimental approach and breaks the data into four groups: two experimental groups (At-Risk CIS students and Not-At-Risk CIS students) and two control groups (At-Risk students and Not-At-Risk students). …

Overcoming Barriers: Factors Of Resiliency In Refugee Students Pursuing Higher Education, Tamika Braye

Electronic Theses and Dissertations

This research looks at the significant barriers that exist in the United States that hinder African refugee youth from being able to pursue their educational goals. According to the literature, language, social, and economic barriers during this pivotal point in their lives are often reasons that refugee students may have a difficult time going to college. Refugee families enter the United States in hopes of a prosperous life. The following research will discuss ways that current or former refugees have overcome these barriers through forms of intervention and acts of resiliency to reach their educational goals. The findings of this …

An Evaluation Of The Impact Of Financial Coaching As A Social Work Intervention In A Church-Based Setting In Texas, Chelsea Fordham

Electronic Theses and Dissertations

Although strides have been made to reduce the negative effects of poverty, the

implementation of effective programs and policies is essential in the fight to end poverty. Literatures suggests that churches and faith-based programs offer clients a unique type of service due to the affiliation of religion that can be used as a strength and sense of support for clients. This study attempts to offer empirical data regarding the effectiveness of a program of this type by exploring the impact of a church-based financial coaching program for participants who received financial assistance and those who did not receive financial assistance. …

The Rhetoric Of The Opioid Crisis And Addiction To Prescription Pain Medicine, Rachel Kaplan

Electronic Theses and Dissertations

In this historical moment, the United States is amidst an opioid crisis killing the young and the old; at least seventy-eight people die every day from an opioid-related overdose (Enomoto in Murthy III). Changing mindsets of the doctors who prescribe opioids is just as important as asking the patients who are prescribed them to demand an alternative medication. The different parties involved in the crisis all have a different agenda and their rhetorical bias is explored throughout this project. The pharmaceutical companies have launched aggressive marketing campaigns expressing the benefits of opioids and encouraged physicians to prescribe, the CDC has …

An Ethical Framework For Organizational Resource Allocation For Patient Services In Health Care, Natalie Dick

Electronic Theses and Dissertations

Unanswered questions on how to allocate scarce resources in health care settings are often left to either bedside decision-making or, at best, the organizational policy level. Yet, there is little attention and no consensus on how organizational policy should address resource allocation in health care. An ethically sound framework is needed to guide policy development for resource allocation within health care organizations. In addition, a more comprehensive study of concepts tied to moral obligations of health care organizations is needed in terms of human rights, health disparities, and patient care quality. Until now, human rights literature has largely focused on …

Using An Ethics Of Care To Re-Interpret Consent In The Management Of Care For Addiction Disorders, Diann Ecret

Electronic Theses and Dissertations

Patients who suffer from the biological, genetic, epigenetic neurocognitive dysfunction and social sequela of substance use disorders and addiction require the empowering support from healthcare professionals; necessitating the need to utilize an ethics of care to re-interpret consent for the management of care for those who suffer from substance use disorders and addiction. The care of the ‘other’ should embrace a care paradigm that is relational and collaborative in order to eliminate constructs of stigma, moral weakness and individual blame, which isolates those who manifest the trajectory of harms associated with addiction pathology. Relational consent and an ethics of care …

An Ethics Of Care Approach To Managing The Burden Of Alzheimer's Disease, Carrie L. Stott

Electronic Theses and Dissertations

Alzheimer’s disease is a progressive, neurodegenerative disease for which there is currently no cure or effective treatments. The disease has devastating effects on the individuals whom it strikes and because its prevalence continues to rise, it significantly threatens the public good. Throughout its lengthy duration from diagnosis to death there are numerous ethical issues concerning patients individually as well as society generally. The management of the burdens of Alzheimer’s disease presents a formidable ethical challenge from the perspective of patients and society. The ethics of care is adopted to address this problem because of its flexibility to integrate personal care …

Body Image, Fear Of Fat, And Attentional Bias For Thin And Non-Thin Bodies, Neusha Khaleghi

Electronic Theses and Dissertations

The study examined the impact of Attentional Bias Modification (ABM) on body image and fear of fat in college women. Participants were randomly assigned to one of two conditions: an ABM condition or a non-ABM placebo condition in viewing a series of thin and non-thin body stimuli. Extending previous work documenting associations between attentional biases and body dissatisfaction and the effects of ABM on body dissatisfaction, we hypothesized that effects of an ABM task designed to direct attention toward non-thin bodies would: (a) decrease body dissatisfaction, (b) increase body appreciation, and (c) decrease fear of fat. There were no significant …

Characterization Of Type Ii Toxin Anti-Toxin Systems In Aggregatibacter Actinomycetemcomitans., Blair W. Schneider

Electronic Theses and Dissertations

Microbes express many protective mechanisms in response to environmental stress. Toxin/anti-toxin systems encode a biologically active toxin and a labile anti-toxin that inhibits the toxin’s activity. These systems are known to contribute to persister cell and biofilm formation. A. actinomycetemcomitans thrives in the complex oral microbial community and is subjected to continual environmental flux. Little is known regarding the presence and function of TA systems in this organism or their contribution survival in the oral environment. Using BLAST searches and other informatics tools, we identified 11 intact TA systems that are conserved across all seven serotypes of A. actinomycetemcomitans and …

Implementation Of Emergency Preparedness In Long Term Care And Rogers' Diffusion Of Innovation Theory., Elizabeth M. Shiels

Electronic Theses and Dissertations

Kentucky is one of the top ten states in the U.S. in the number of Presidential Declarations of Disaster (PDD) over the past ten years. This is due to its geology and weather patterns. The far western portion of Kentucky lies on the New Madrid Seismic Zone, one of the most dangerous fault lines in the United States; and natural hazards such as tornadoes, earthquakes, flash floods, severe storms offer only minutes or even seconds of advance notice. These “no-notice” emergencies with no timely warnings are the most common hazards experienced in Kentucky. In these events, individual long term care …

Feeding Behaviors And The Child With Posterior Tongue-Tie : Comparison To Norms., Mckenzie Sexton

Electronic Theses and Dissertations

The tongue is an important muscle used in speech, mastication, swallowing, and breastfeeding. It plays an important role in facial development, dentition, and periodontal status. Posterior ankyloglossia, also known as posterior tongue-tie (PTT), is characterized by a tether beneath the lingual mucosa. Upon visual inspection, the frenulum is non-prominent but with the use of a grooved director it may appear abnormally prominent, short, thick, or cord-like. Palpation of the frenulum may reveal tightness. There is a lack of empirical data about PTT and the impact on feeding beyond early infancy. PTT is not well recognized and can be missed resulting …

Malaria In The Prehistoric Caribbean : The Hunt For Hemozoin., Mallory D. Cox

Electronic Theses and Dissertations

With the increase in resistance to anti-malarials and global warming trends expanding the habitation range of the mosquito vector, research highlighting the biogeographical contexts of infected populations is critical to understanding epidemiological patterns. A bioarchaeological approach to epidemiology can shed light on previous disease patterns and aid in the prediction of future outbreaks of diseases like malaria. Currently, there is no direct evidence of malaria in the Americas prior to European contact; however, skeletal, archaeological, paleoenvironmental, historic, and ethnohistorical evidence strongly suggest the presence of Plasmodium spp. malaria in indigenous Caribbean skeletal remains held in the Yale Peabody Museum of …

Killing Martin County : Resiliency In A Central Appalachian Community., David Adam Sizemore

Electronic Theses and Dissertations

Environmental stressors, anything that poses a threat to human and environmental health, are disproportionately located in marginalized communities. Coal extraction companies produce and concentrate environmental stressors in Central Appalachia, a sub-region of Appalachia with high poverty rates and economic hardship. Through destructive coal extraction methods, the coal industry has jeopardized Central Appalachian health and environmental quality. The coal industry’s power to cause destruction in Central Appalachia is a product of historical strategic initiatives. Since the late 1800s, the coal industry has forcefully altered the culture and ideology of Central Appalachians and developed relationships with local, state, and federal policymakers to …

The Effects Of Polychlorinated Biphenyls Exposure On Non-Alcoholic Fatty Liver Disease : Role Of Aryl Hydrocarbon Receptor., Hongxue Shi

Electronic Theses and Dissertations

Polychlorinated biphenyls (PCBs) are detectable in serum of 100% of adults in US, and has been associated with fatty liver disease in epidemiological studies. PCBs are classified as either dioxin-like (DL) or non-dioxin-like (NDL) PCB based on their ability to activate the aryl hydrocarbon receptor (AhR). We used exposures that reflect human bioaccumulation patterns, which resembles Aroclor 1260 with a low level of the DL-PCB, PCB 126. Our aim was to determine if this exposure will activate the human and mouse AhR and examine if receptor activation influences these steatotic responses due to PCB exposures. DL-PCBs exposure-induced AhR activation in …

Inflammasome Independent Leukotriene-B4 Production Drives Crystalline Silica Induced Sterile Inflammation., Bindu Hegde

Electronic Theses and Dissertations

Silicosis is an irreversible lung inflammatory disease caused by chronic exposure to crystalline silica (CS) and is one of the most prevalent occupational diseases worldwide. Lipid chemoattractant Leukotriene B₄ (LTB₄) plays an important role in neutrophilic inflammation that drives silicosis and promotes lung cancer. Previous studies in our laboratory have demonstrated that CS-induced neutrophilic inflammation and lung tumor burden in K-ras^LA1 mice is abrogated in the LTB₄-receptor deficient mice. Another pathway whose importance is well studied in the progression of silicosis is the Nalp3 inflammasome pathway. Studies have shown inflammasome- dependent IL-1b to be …

Vinyl Chloride Enhances Diet-Induced Liver Injury Via Metabolic Dyshomeostasis : Critical Role Of Mitochondria., Anna L. Lang

Electronic Theses and Dissertations

Background. Vinyl chloride (VC) is an environmental toxicant and has been shown to be directly hepatotoxic at high exposures. However, recent studies suggest low-level toxicant exposure can cause subtle changes to the liver. Given the high prevalence of non-alcoholic fatty liver disease (NAFLD) in the United States, it is important to determine the impact of low-level toxicant exposure on the progression of underlying liver injury when combined with other factors. Therefore, the overarching goal of this dissertation was to develop a model of VC co-exposure with high-fat diet (HFD) and to determine the mechanisms by which VC contributes to the …

Nutritional Virulence Of Legionella Pneumophila., Ashley M. Best

Electronic Theses and Dissertations

Legionella pneumophila is an environment organism that parasitizes a wide range of protozoa. Growth within the environmental host primes L. pneumophila for infection of human alveolar macrophages when contaminated aerosols are inhaled. Intracellular replication within either host requires the establishment a replicative niche, known as the Legionella-containing vacuole (LCV). Biogenesis of the LCV depends on the type IVb translocation system, the Dot/Icm, to translocation >320 effectors into the host cytosol. Effectors are responsible for preventing lysosome fusion to the LCV, recruitment of ER-derived vesicles to the LCV, and modulation of a plethora of host processes to promote the intracellular …

The Effects Of Habitat And Connectivity On Tropical Ant Ecology And Behavior., Benjamin Jacob Adams

Electronic Theses and Dissertations

This dissertation explores the role that physical connections among and within habitats play in determining the local diversity and behaviors of cursorial organisms. Understanding the processes that regulate local community assembly and that contribute to the maintenance of species diversity is a cornerstone of community ecology. Ants are a useful model for studies of local communities because they are abundant and fulfill a variety of ecological roles. Chapter one of the dissertation examines the how lianas (woody vines) function as connective structures among tree crowns and how these connections affect arboreal ant community structure within a tropical forest canopy. Trees …

Divergent Evolution Of Di-Lysine Er Retention Vs. Farnesylation Motif-Mediated Anchoring Of The Ankb Virulence Effector., John David Perpich

Electronic Theses and Dissertations

Legionella pneumophila is an aquatic organism capable of intracellular replication within a wide range of protozoan hosts and within human macrophages where it causes Legionnaires’ Disease. L. pneumophila manipulates a variety of host cell processes by translocating, into the host cell cytosol, more than 300 effector proteins via the type IVB secretion system (T4SS). The AnkB effector from the AA100/130b strain (AnkB-AA100) contains a C-terminal CaaX motif that rapidly becomes farnesylated upon translocation into the host cell and anchored to the cytosolic face of the Legionella-containing vacuole (LCV) membrane, which is essential for intracellular replication. We show that a …

A New Surgical Approach For O-C2 Fusion, Solving The Problem Of Dysphagia., M. Kathryn Mcclure

Electronic Theses and Dissertations

The fusion of the second cervical vertebrae to the occipital bone (O-C2 fusion) for head stabilization can result in postoperative dysphagia and dyspnea, negatively impacting the patient’s quality of life. Currently, the O-C2 angle is used for head placement, which may not place the head neutrally. We hypothesize that aligning the external auditory meatus with midline of the C2 will reduce oropharyngeal stenosis, reducing dysphagia. One male patient with poor swallow quality of life who required a revision of a previous O-C2 surgery was evaluated via videofluoroscopy and completed the standard swallow quality of life questionnaire (SWAL-QOL) before and after …

Tissue Engineered Micro And Macrovasculature Utilizing Stromal Vascular Fraction., Joseph Samir Zakhari

Electronic Theses and Dissertations

This dissertation describes the use of stromal vascular fraction to tissue engineer 3D microvasculature and macrovasculature. Stromal vascular fraction is an easily isolatable cell source from adipose tissue depots. It has demonstrated remarkable potential both in vitro and in vivo for forming microcirculation capable of perfusion upon implantation. SVF is clinically utilized as a therapeutic cell source for anti-inflammation for osteoarthritis and is being studied for ischemic tissue application to stimulate revascularization. The work described herein is divided within four chapters. Chapter I provides an introductory overview and lists the aims and hypothesis for the dissertation. Chapter II describes experiments …

Optimizing High-Speed Exercise Performance : Effect Of Load., Ling Bai

Electronic Theses and Dissertations

The purpose of this study was to identify an optimal load for the knee extension exercise done with Impulse (Newnan, GA). Forty-one women and twenty-nine men made six laboratory visits, including two familiarization sessions of the knee extension exercise and four real workout sessions which entailed four 30-second exercise sets, separated by 120-second rests, against four different loads (0Kg, 3.41Kg, 5.68Kg, 7.95Kg). A Latin Squares design was used to counterbalance the sequence of the sets. Average force (AF), peak force (PF), total work (TW), Impulse value, and the number of knee extension repetitions were each analyzed with a 2 (gender) …

A Model To Study The Effects Of Whole Life Chronic Exposure To Arsenic Or Cadmium On The Development Of Adult Metabolic Syndrome : Initial Characterization Of Hepatic Changes., Jamie L. Young

Electronic Theses and Dissertations

Metabolic syndrome (MetS) is a group of diseases affecting < 30% of adults. Although obesity is a major risk for the development of MetS, it does not account for all cases, suggesting contribution of other risk factors. We hypothesized that early life exposure to arsenic (As) or cadmium (Cd) may represent such a risk. The purpose of this study was to characterize a model to discern the effects of early life exposures to Cd and As on high fat diet (HFD)-induced MetS. Adult C57BL/6J mice were exposed to control or metals containing drinking water. Pregnant dams and offspring were continuously exposed to the same toxicants as their parents. At weaning, offspring were fed LFD or HFD and sacrificed 10 or 24 weeks later. Metal exposure caused time- and sex-dependent alterations in HFD-induced variables of liver damage. The initial results suggest that these toxicants enhanced obesity-induced liver injury.

Comparative Analysis Of Survival And Decay Of Fecal Indicator Bacteria In Bovine Feces And Freshwater Microcosms, Reem Tariq

Electronic Theses and Dissertations

Agricultural runoff can carry FIB that can pollute surface waters through the soil matrix. This study was designed to inspect the impact of temperature and matrix on the survival of FIB. The FIB were routinely enumerated over an 18-day period from fecal samples and freshwater microcosms maintained at 4oC, 22oC, and 35oC. It was found that the FIB studied underwent a primary growth of up to 1-log10 to 3-log10, highlighting the weakness of conventional FIB as indicators of pathogen contamination. The concentrations of FIB in the water phase were found to be significantly greater than those observed in the fecal …

Escaping The Arrhenius Tyranny: Metabolic Compensation During Exposure To High Temperature In Daphnia, Bret L. Coggins

Electronic Theses and Dissertations

Poikilothermic organisms experience trade-offs by differential physiological demands generated by temperature extremes. Many such organisms exhibit acclimatory effects, adjusting their metabolism and physiology to recently experienced temperatures. One such acclimatory effect is metabolic compensation, the deceleration of biological rates below Arrhenius expectations. Daphnia magna is eurythermal, and if acclimated to mildly stressful temperatures first, survives longer in lethal temperatures. This study examined the effect of ambient temperature (5°C-37°C) and acclimation history (lifetime at 10°C or 25°C) on the oxygen consumption rates of 8 genotypes of Daphnia with high or low acute temperature tolerance. There were decelerations of respiratory rates across …

The Effect Of Ethanol On Skeletal Muscle Endocrine Function And The Novel Myokines Myonectin And Irisin, Kendra Hagood

Electronic Theses and Dissertations

Excessive alcohol consumption is a leading cause of death and disability globally and can lead to diseases such as alcoholic skeletal myopathy. Skeletal muscle is the largest organ in the human body and functions to regulate whole-body energy homeostasis. Additionally, skeletal muscle can function as an endocrine organ via secretion of myokines. Two myokines, myonectin and irisin, present a wide range of effects upon metabolism, inflammation, and tissue survival- signaling. We hypothesized that chronic alcohol consumption will result in reduced circulating myonectin and irisin levels. Mice were fed an ethanol-containing or control diet for 10 days or 6 weeks. Tissues …