Digital Commons Network^™

Synthetic And Pharmacological Diversity Of Nitrogen-Containing Heterocycles., Shramana Ghosh

Electronic Theses and Dissertations

Nitrogen-containing heterocycles are a foundational class of compounds in organic chemistry, playing critical roles in pharmaceuticals, agrochemicals, and natural products due to their structural diversity and biological relevance. Among them, isoindolinones are notable for their wide range of pharmacological activities. Structurally, isoindolinones possess a benzylic methylene group adjacent to the nitrogen atom, which allows for selective oxidative transformations to yield phthalimide derivatives, well-known intermediates in synthetic, pharmaceutical, and materials chemistry. Although phthalimide is traditionally employed as a protecting group for amines via the Gabriel synthesis, isoindolinone offers a valuable alternative. Through a modified Gabriel-like approach, isoindolinones can serve as more …

The Influence Of Psychological, Biological, And Social Determinants On Disordered Eating Behaviors Among U.S. Young Adults: Evidence From Nhanes 2015-2018., Samantha Kaye Gerbine

Electronic Theses and Dissertations

Disordered eating behaviors (DEBs) are influenced by biological, social, and psychological factors, yet research often narrowly focuses on White, college-aged women. This study assessed the predictors and prevalence of DEBs in a nationally representative sample of U.S. young adults using data from the 2015–2018 National Health and Nutrition Examination Survey (NHANES). Survey weights were applied to generate national estimates. Descriptive statistics characterized the sample, and logistic regressions tested biological, social, and psychological predictors of DEBs. A composite risk score was developed using variables retained in the final model. The unweighted sample (n = 1,062) represented 64 million U.S. young adults. …

Crossed Stitches: Tension And Transformation In Nineteenth-Century Embroidery Samplers., Hayley Salo

Electronic Theses and Dissertations

Originally designed as practice pieces, embroidery samplers have long been studied as domestic objects and part of sewing history. Interpretations of the material and textual significance of individual samplers is less common. However, recent scholarly attention has turned to using sewing practices and objects as a means for understanding individual stitchers and their contributions to public discourse. As such, a focused study of the material and textual content of embroidery samplers furthers our understanding of the genre on its own and as a wider textile practices. Crossed Stitches is interested in the production, portability, circulation, and reception of embroidery samplers …

"That’S Not A Meal, Bestie”: Humor, Identity, & Feminized Consumption In “Girl Dinner”., Claire Tudor

Electronic Theses and Dissertations

This thesis examines the viral “Girl Dinner” trend as a case study in how gendered consumption, digital identity, and feminist humor intersect in digital spaces. Using “Girl Dinner” as a rhetorical artifact, this thesis explores how women use gendered trends to navigate visibility, labor, and autonomy in online spaces. Through thematic analysis of TikTok content, media coverage, and branded adaptations, the research traces the evolution of the trend from a lighthearted joke to a site of cultural negotiation. This study reveals that while “Girl Dinner” may appear empowering and relatable on the surface, it often reinforces traditional gender expectations under …

Rhetorical Analysis Of Kristen Bell's Articulation Of Imperfect Motherhood On Armchair Expert., Sarah J. Neff

Electronic Theses and Dissertations

This thesis explores how Kristen Bell’s articulation of imperfect motherhood, as heard on the popular podcast Armchair Expert, contributes to broader social discourses surrounding motherhood, empowering some mothers while inadvertently constraining others. Using rhetorical analysis grounded in Goffman’s dramaturgical approach, facework theory, and McGee’s theory of fragments, this study explores Bell’s discourse and performance of motherhood within the podcast medium. The podcasting medium provides a rich source for rhetorical analysis due to the long form interview content, and emotionally nuanced content, leading to a stronger connection with the audience. This is evident with the new headlines that follow Bell’s appearance …

The Substance Of Reality: Moral Perfectionism In Shakespeare's Hamlet., David Wright

Electronic Theses and Dissertations

Through a selection of and close reading of key passages, I offer an interpretation of Hamlet that seeks to illuminate the play as an important work of moral philosophy, and to situate the play within a strand of moral philosophy named moral perfectionism by Stanley Cavell. Indeed, Hamlet is a masterpiece of Renaissance drama, but when read with attention to moral perfectionism, the play yields additional layers of meaning. Hamlet is a “philosophical drama” that navigates the “moral calling of philosophy”—a text that seems to, almost uncannily, elicit the audience to think reflectively, to ask fundamental human questions along …

Incarcerated Women: Gendered Rhetoric From The Outside And Reality Inside Prison Walls., Taylor Riley Geiser

Electronic Theses and Dissertations

This dissertation examines how formerly incarcerated women navigate and resist gendered media portrayals through digital platforms, focusing on the “mad” and “bad” woman tropes that shape public perceptions. Drawing on feminist rhetorical theory—particularly Royster and Kirsch’s methodological practices and Ratcliffe’s concept of rhetorical listening—this study combines Critical Discourse Analysis (CDA) of mainstream headlines with Multimodal Discourse Analysis (MDA) of TikTok content. CDA of media coverage surrounding Lori Vallow Daybell, Casey Anthony, and Andrea Yates reveals how language, imagery, and cultural logics sustain harmful binaries that portray women who commit crimes either as depraved or as excused by madness, obscuring the …

Why Are Parents Choosing Forest Preschool? A Look Into Parent Choice And Outcome Expectations In A Forest Preschool Setting., Victoria M. Jones

Electronic Theses and Dissertations

As interest in alternative early childhood education settings continues to grow, Forest Preschools—programs emphasizing immersive outdoor, nature-based learning—have gained increasing attention from parents across the United States. This qualitative research study explores the underlying motivations and decision-making processes that lead families to choose Forest Preschool settings. Guided by Kurt Lewin’s Field Theory, which examines behavior as a function of person and environment, the study investigates the dynamic interplay of personal beliefs, social influences, and contextual factors that shape parental choice. Specifically, this study addresses four key research questions: (1) How do families who choose Forest Preschools gain information about preschool …

Mindfulness As A Protective Factor In Women’S Sexual Health, Shana Byerley

Electronic Theses and Dissertations

Many women who experience physical health complaints also report sexual dysfunction across a variety of domains including decreased arousal, desire and satisfaction. Although there are well-established connections between disease-specific populations and sexual dysfunction, less research has focused on women who experience somatic symptoms more broadly. Similarly, mindfulness as a treatment intervention has been applied across many facets of sexual functioning, but mindfulness as a trait characteristic has been less explored in its connections with generalized somatic complaints. Further, the within-domain interactions between facets of mindfulness and domains of sexual dysfunction have not been previously explored. Using data from an online …

An Examination Of Legal Status, Law Enforcement Perception, And Crime Victimization And Reporting Among Hispanic Immigrants, Guadalupe C. Cabrera

Electronic Theses and Dissertations

This study relied on in-depth interviews with naturalized citizens and lawful permanent resident Hispanic immigrants to explore their perceptions of law enforcement and experiences with crime victimization and reporting. Past literature has explained that the absence of legal status may deter crime reporting. We added to this body of work by investigating relationships among legal status, trust, and reporting behaviors. This study finds that direct experiences with law enforcement and acquired knowledge may be a better indicator of law enforcement trust and crime reporting compared to legal status. While most participants expressed trust in law enforcement, others felt neutral due …

A Tale Of Two Toxicants: Investigating The Interaction Between Hexavalent Chromium And Perfluorooctane Sulfonic Acid., Morgan Elizabeth Delnicki

Electronic Theses and Dissertations

Hexavalent chromium [Cr(VI)] and per- and polyfluoroalkyl substances (PFAS) are environmental contaminants of major public health concern. Despite commonly being found together in contaminated drinking water, no studies have considered the concomitant health effects of Cr(VI) and PFAS, specifically perfluorooctane sulfonic acid (PFOS). In vitro studies using CHO cells assessed the cytotoxicity and genotoxicity of Cr(VI) and PFAS both individually and in combination. Intracellular and extracellular Cr levels were measured with Atomic Absorption Spectrometry. PFOS was found to exacerbate Cr(VI) induced cytotoxicity and genotoxicity. Additionally, a novel in vivo model of studying the hepatotoxicity of Cr(VI) was established. Adult Hartley …

An Exploration Of Lgbtq+ Runner Motivation And Constraints., Michael Clemons

Electronic Theses and Dissertations

Running offers extensive benefits beyond physical fitness, encompassing mental, emotional, and social advantages. However, LGBTQ+ individuals face unique challenges in participating in the running community, which remains predominantly White, cisgender, and heterosexual. With the LGBTQ+ population in the U.S. growing, there is a need to understand their motivations and barriers to participation in running events and training groups. This study explores these motivations using self-determination theory, comparing LGBTQ+ and non-LGBTQ+ runners to identify differences in driving factors such as social connectivity, self-esteem, and competition. Additionally, it examines barriers LGBTQ+ runners face, ranging from structural obstacles to intrapersonal challenges, and how …

Therapeutic Potential Of Sglt2 Inhibitors In A Repeated Love Dose Cisplatin Model., Dianet C. Sanchez

Electronic Theses and Dissertations

Cisplatin is a potent chemotherapeutic, thirty percent of patients develop Acute Kidney Injury (AKI). These patients are ten times more likely to develop chronic kidney disease (CKD). Sodium-glucose-cotransporter-2-inhibitors (SGLT2i), FDA approved for diabetes, has shown protection in multiple mouse models of AKI-CKD. We hypothesize SGLT2i can protect the kidney in a model of repeated low dose cisplatin with/without cancer. B6:129 mice with/without lung adenocarcinoma (Lung-adeno) were treated daily with SGLT2i dapagliflozin (10mg/kg)/vehicle control. After seven days, weekly cisplatin (7mg/kg)/vehicle control was initiated for 3-4 weeks. Following final cisplatin dose, kidney function, injury, fibrosis, inflammation was assessed. SGLT2i treatment attenuated alterations …

An Exploration Of Factors Influencing Sophomore-Year Persistence At A Regional Institution In Southern Appalachia, Jonathan W. Mitchell

Electronic Theses and Dissertations

The purpose of this qualitative and interpretative phenomenological study was to explore factors that participants identified as playing roles in their persistence through their sophomore years at a regional university located within Southern Appalachia. Research on second-year retention efforts is far lacking compared to first-year retention efforts. Reflecting the heavy emphasis placed on the first year, there is also more research on first-year retention. However, students can feel a sharp decline in support entering sophomore year, making that just as critical of a transition. Student retention has been emphasized in higher education since its inception, as an institution’s goal in …

Popular Culture As Conduit: Navigating Integrated Marketing Communication In An Age Of Hyperconsumerism, Abbey N. Mccann

Electronic Theses and Dissertations

This dissertation examines the discipline and practice of integrated marketing communication, acknowledging the limitations inherent in analyzing a field deeply embedded in the structures of hyperconsumption. This inquiry adopts a constructive hermeneutic approach, interpreting the dialectical tensions that define integrated marketing communication. These tensions include that between commercial imperatives and cultural critiques, which are further complicated by the influence of popular culture and shifting political climates. As popular culture increasingly intersects with sociopolitical discourse, brands are compelled to navigate these dynamics publicly. This evolving landscape reshapes consumer perceptions and brand strategies, reinforcing integrated marketing communication’s role as both a cultural …

Investigating The Multiple Enzyme Complex In The Carotenoid Biosynthesis Pathway, Mercy Mormor

Electronic Theses and Dissertations

In nature, plant carotenoids are 40-carbon isoprenoids with polyene chains that may have double bonds. They are vital components of all photosynthetic organisms, playing several roles in the plant cell, including photosynthesis, pigmentation, phytohormone synthesis, signaling and photoprotection. In this study, we investigated protein-protein interactions among key enzymes involved in the carotenoid biosynthesis pathway using the Bimolecular Fluorescent Complementation (BiFC) assay. Our results revealed several interactions that suggest a coordinated regulation of enzymatic activity within this pathway, highlighting potential regulatory complexes that influence carotenoid production. The study also highlights the pivotal role of Zeta-Carotene Isomerase (Z-ISO) as a key regulatory …

Examining The Lived Experiences Of International Students At East Tennessee State University, John The Baptist Anodjo

Electronic Theses and Dissertations

This research investigates the lived experiences of international students at East Tennessee State University (ETSU), specifically examining how they navigate social, academic, and structural challenges. Through in-depth interviews with 20 international students from a variety of nationalities, I analyzed issues related to legal status, housing, food insecurity, healthcare, and social integration. I found that students encounter barriers due to immigration policies, financial constraints, and limited access to essential resources. Additionally, international students benefit significantly from support provided by campus services, community organizations, and their social networks, which play a vital role in their adjustment process. While institutional resources are beneficial …

"No One Leaves For Free": A Media Analysis Of The Lived Experiences And Cumulative Impacts Of The Flint Water Crisis., Jordan Leigh Gatewood

Electronic Theses and Dissertations

In April 2014, the city of Flint, Michigan changed their municipal water source from Lake Huron to the Flint River. The effects of this change have been felt far and wide as news broke across the nation that this water was contaminated with lead and residents of Flint were getting sick. This research analyzes 170 news articles from three local and three national news outlets over a 10-year span, 2014 to 2024, to determine how community voice is presented in news media to portray the lived experiences and cumulative impacts of the Flint Water Crisis. Applying a Critical Environmental Justice …

The Diversity Of Our Weightlifting Uniforms: A Qualitative Analysis Of The Experiences Of Gender And Sexual Minorities In Gyms, Rachel M. Schott

Electronic Theses and Dissertations

Gender and sexual minority (GSM) populations experience significant mental and physical health disparities compared to their cisgender, heterosexual counterparts. A particularly understudied modality that may contribute to these disproportionate health outcomes is decreased engagement in physical activity (PA). Gyms are a primary source for PA, yet understanding GSM experiences in these spaces is relatively understudied. The purpose of the present study is to better understand the experiences of GSMs in gym spaces with an emphasis on barriers and facilitators to their engagement. We conducted semi-structured phone interviews among self-identified gender and sexual minorities across the U.S. Thematic analysis was used …

Isolation And Characterization Of Siderophore(S) From Pseudomonas Mosselii, Casey J. Stophel

Electronic Theses and Dissertations

Iron is essential for growth of most microorganisms. It functions as an important cofactor in many important biological processes. However, iron found in soil is rendered insoluble and unavailable to microorganisms for use. To overcome this, many bacterial species produce siderophores, a small organic molecule that has high affinity for iron. Siderophores allow for bacterial cells to obtain otherwise insoluble iron. Pseudomonas mosselii, a Gram negative bacterium, was isolated from a local soil sample. P. mosselii was found to produce siderophore(s) under iron restricted environment, however, they have not been characterized. Therefore, it was of interest to isolate, purify and …

The Intersection Of Appalachian Identity And Gambling Behavior, Noah S. Anderson

Electronic Theses and Dissertations

This study examined the relation between Appalachian identity and gambling behavior among students in central Appalachia (n = 395). One-way ANOVAs revealed no significant differences in engagement, F(2, 392) = 0.65, p = .523, or severity, F(2, 392) = 0.33, p = .718, across identification groups. Moderated regression showed that identity did not significantly moderate the engagement–severity relation (B = 0.073, p = .099), though engagement itself was a strong predictor of harm (B = 0.696, p < .001, R² = .521). Negative affect predicted both engagement (B = 0.074, p = .001) and severity (B = 0.069, p = .001), while identity remained non-significant. Logistic regression found that identity predicted gambling engagement (Exp(B) = 1.18, p = .034) only when controlling for severity. These findings relay the importance of empirical efforts in Appalachia and suggest that Appalachian identity may not be an independent risk factor in gambling behavior.

Evaluating Online Autism Information: A Content Analysis Of Language, Quality, And Interventions, Jada R. Beal

Electronic Theses and Dissertations

The internet is a widely used source of autism-related information, yet previous studies demonstrate that the quality, accuracy, and language used in such content remain inconsistent. This study conducted a content analysis of 356 autism-related internet sources obtained from top Google search results, examining their use of neurodiversity-affirming language, the quality of health-related information, and the inclusion of evidence-based interventions. Results showed that medical model language and person-first terminology were more common than neurodiversity-affirming language. Sources targeting caregivers were significantly more likely to use medical model language than those aimed at autistic adults. Only 12.92% of sources included quotes or …

Drivers And Consequences Of Changes In Nectar Microbiome Composition Across Spatial And Biological Scales, Daniel A. Barker

Electronic Theses and Dissertations

Microbial communities inhabiting floral nectar, known as the nectar microbiome, are important mediators of plant-pollinator interactions. However, the ecological and environmental factors that shape the composition of these microbial communities remain poorly understood. While previous studies have examined the effects of a few microbial groups, typically independent of one another, on one plant or pollinator species, this dissertation takes a wide-scale approach to explore how abiotic conditions and biotic interaction’s structure microbial communities within floral nectar. Furthermore, I also quantify how variation in microbial richness and identity influences pollinator behavior and plant reproductive success.

This dissertation shows that microbial abundance …

In A Safe-Space Of Her Own: Alice's Journey Through A Traumatized Wonderland To Find Attunement And Recovery, Cheston A. Axton

Electronic Theses and Dissertations

Throughout Alice’s Adventures in Wonderland/Through the Looking-Glass’s 160-year existence, Lewis Carroll’s seven-year-old protagonist has experienced many changes and alterations. With an ever-growing pop culture interest, Alice’s original narrative has undergone numerous adaptations, with each new variation diving deeper into the impact of trauma on Wonderland.

This thesis continues this existing discourse by examining Wonderland’s capacity to facilitate recovery in the aftermath of severe trauma. Through this research, the traumatic experiences of Alice, from Christina Henry’s The Chronicles of Alice: Alice and American McGee’s Alice: Madness Returns, are examined concerning their effect(s) on her construction of Wonderland, as …

An Evaluation Of Key Components Of Natural Resource Camps, Undergraduate Persistence And Success In Natural Resources, Brandy Bishop

Electronic Theses and Dissertations

This study explores the key components that connect natural resource camps, undergraduate persistence, and overall success through gainful employment within the natural resource industry. The aim of this study was to assess early interest and attitudes towards natural resource career pathways and how education interventions shape students’ career outcomes thus leading to overall success. A longitudinal mixed method design was used combining Conservation Careers Camp survey data (n = 39) with institutional records for Forestry majors (n =655) in the Arthur Temple College of Forestry and Agriculture on the Stephen F. Austin State University campus. Quantitative data was analyzed through …

An Exploratory Descriptive Study Of Urban Professional High School Counselors' Work Culture, Burnout, And Mental Well-Being, Alexandria L. Hall

Electronic Theses and Dissertations

This descriptive, exploratory, qualitative study examined urban, public U.S. high school counselors’ perceptions of job-related stress, autonomy, and administrative support within urban school environments. Seven current high school counselors working in urban public schools were recruited through convenience sampling in educator forums on Facebook, followed by snowball sampling to expand the participant pool. Counselors participated in semistructured interviews conducted via Zoom or asynchronous online focus groups hosted on Padlet, depending on the participant’s preference. Data were analyzed using Braun and Clarke’s six-step thematic analysis process, supported by Dedoose software for coding and data management. The analysis revealed four major themes: …

Overcoming Second-Order Barriers To Teachers’ Technology Integration: A Study Of Positive Impacts, Crystal Ann Hume

Electronic Theses and Dissertations

This study explored K–12 public school teachers’ self-efficacy, value, and pedagogical beliefs about technology. The teachers worked in a medium-sized, semi-affluent public school district in North Texas. The study investigated second-order barriers to technology integration and what might positively impact teachers’ self-efficacy, value, and pedagogical beliefs. This study used a qualitative descriptive methodology to collect qualitative data about their beliefs by interviewing and observing K–12 classroom teachers who had completed a bachelor’s degree through a traditional teacher education program. Teachers with alternative certifications or noncertified classroom instructors were omitted. Findings revealed that external factors, failure, mistakes, confidence, and professional development …

Principal Self-Efficacy: A Qualitative Study, Vance E. Self

Electronic Theses and Dissertations

This qualitative study explored elementary principals’ perspectives on the importance of selfefficacy in relation to management responsibilities, instructional leadership, and moral leadership as they impact student achievement measured by the STAAR in a Central Texas school district. The research addressed the growing challenges principals face in high-accountability environments, focusing on how their beliefs in their leadership abilities affect school performance and student outcomes. The purpose was to examine principals’ views on selfefficacy across three domains and to consider implications for leadership preparation, district support, and policy. The study was grounded in a constructivist paradigm and employed a qualitative case study …

Institutional Betrayal And Military Vaccine Mandates: An Inquiry Into Loss Of Health Autonomy Concerning Unlimited Liability Contractual Employment In The Covid-19 Era, Aaron G. Dehaven

Electronic Theses and Dissertations

The balance between government control and personal liberty is a growing concern in the modern world. Nowhere is this more evident than in discussions surrounding government policy in public health and individual health autonomy. The Covid-19 pandemic forced many institutions to change their standard operating procedures by adapting to rapidly changing health guidance instituted to protect public health. These changes highlighted the role of health autonomy and individuals’ rights to refuse medical treatments. The Department of Defense changed many aspects of how it operated during the pandemic, including the mandate of the Covid-19 vaccine for all service members. For various …

Unheard Echoes: Undocumented Students’ Success Amidst Challenges At U.S. Higher Education Community Colleges, Elvia Ortiz Segura

Electronic Theses and Dissertations

This qualitative descriptive study explored the lived experiences of undocumented Latinx students at a southern U.S. community college, identifying support services that assisted students with barriers that emerged in their academic journey. The problem of the study was the complex challenges undocumented students face in higher education and how they are addressed and supported. The research used a qualitative descriptive methodology to magnify student voices and influence institutional policies. Using Bronfenbrenner’s ecological systems theory as the theoretical framework, this study examined how family, culture, policy, and institutional systems influenced undocumented students’ educational journeys. Data were collected through semistructured interviews with …