Digital Commons Network^™

Trust In Primary Care Providers: Perspectives From Deaf People., Greir Ander Huck Flynn

Electronic Theses and Dissertations

Trust is an integral part of the patient-provider relationship, responsible for influencing several key aspects of healthcare behaviors and patient perceptions of health outcomes. Though the topic has previously been discussed by scholars, little evidence exists to support the application of our understanding of trust in culturally Deaf populations. As such, this dissertation seeks to lay the necessary groundwork for further investigations on the topic by first understanding the nature of trust in patient-provider relationships from the perspectives of culturally Deaf people. The dissertation is comprised of five chapters. The first chapter provides an introduction to salient terms and concepts …

Tumor-Derived Exosomes Drive Immunosuppressive Macrophages In A Pre-Metastatic Niche Through Nf-Kβ Dependent Glycolytic Metabolic Reprogramming., Samantha M. Morrissey

Electronic Theses and Dissertations

The formation of a pre-metastatic niche is a fundamental requirement for primary tumor metastasis. One of the defining characteristics of a pre-metastatic niche is infiltration of immunosuppressive macrophages. However, how these macrophages acquire their immunosuppressive phenotype remains largely unexplored. Here, we demonstrate that tumor-derived exosomes (TDE) polarize macrophages towards an immunosuppressive phenotype characterized by increased PD-L1 expression through NF-kB-dependent metabolic reprogramming in mice and humans. While NF-κB has previously been shown to act as a direct transcription factor for PD-L1, we report a novel mechanism where TDE-induced NF-κB activation drives PD-L1 expression by augmenting the glycolytic capacity of macrophages through …

Genes Involved In Nitrogen Assimilation In Ustilago Maydis., Sunita Khanal

Electronic Theses and Dissertations

U. maydis can utilize nitrate as a source of nitrogen from its environment, a process requiring a nitrate transporter to bring the nitrate inside the cell. This is followed by a two-step reduction of nitrate to ammonium. At first, nitrate reductase reduces nitrate into nitrite; in the second reaction, nitrite is reduced to ammonium by nitrite reductase. The goal of the study was to identify the nitrate transporter and nitrite reductase genes in U. maydis and characterize them based on their role in mating and virulence. The genes um03848 and um03849 were identified bioinformatically as encoding, respectively, the nitrite reductase …

Water Cluster Motifs In Structurally Similar N-(2-Aminoethyl)-1-Methylimidazole-2-Carboxamide Metal Complexes: Synthesis, Characterization, Thermal And Electrical Properties., Nina Saraei

Electronic Theses and Dissertations

Water is a remarkable molecule and in all of its forms exhibits an amazing collection of properties and functions. Besides its crucial role in life and many technological processes, water displays some unusual and anomalous properties at various interfaces and under different conditions. Although the role of hydrogen-bonding interactions and their fluctuations are well known to determine the properties of water, the main obstacle exists in the complexity of correctly describing the interactions between water molecules. The key to understanding the behavior of water is to collect precise structural data of various H-bonded water networks in diverse environments. In this …

Plasmodium Impairs Antibacterial Innate Immunity To Systemic Infections In Part Through Hemozoin-Bound Bioactive Molecules., Christopher Lynn Harding

Electronic Theses and Dissertations

Despite efforts to decrease the global health burden of malaria, infections with Plasmodium species continue to cause over 200 million episodes of malaria each year which resulted in 405,000 deaths in 2018 [1]. One complication of malaria is increased susceptibility to invasive bacterial infections. Plasmodium infections impair host immunity to non-Typhoid Salmonella (NTS) through activities of heme oxygenase I (HO-I) )-induced release of immature granulocytes and myeloid cell-derived IL-10. Yet, it is not known if these mechanisms are specific to NTS. We show here, that Plasmodium yoelii 17XNL (Py) infected mice had impaired clearance of systemic Listeria monocytogenes (Lm) during …

Making Modality: Transmodal Composing In A Digital Media Studio., Chris Scheidler

Electronic Theses and Dissertations

The multiple media that exist for communication have historically been theorized as possessing different available means for persuasion and meaning-making. The exigence of these means has been the object of theoretical debate that ranges from cultural studies, language studies, semiology, and philosophies of the mind. This dissertation contributes to such debates by sharing the results of an ethnographically informed study of multimedia composing in a digital media studio. Drawing from Cultural Historical Activity Theory and theories of enactive perception, I analyze the organizational and infrastructural design of a media studio as well as the activity of composer/designers working in said …

The Nigerian-American Immigration Experience: Overcoming Adversity Through Resilence., K. Chinwe Idigo

Electronic Theses and Dissertations

Nigerian-Americans are a fast-growing population in the United States, when compared to other immigrant groups. Despite growing numbers there is limited empirical research examining pathways that facilitate success among this immigrant population. This study addresses the dearth in literature by proposing and testing a modified ABCX model of family resilience among Nigerian-Americans. It is hypothesized that similar to other immigrant, and racial/ethnic minority groups in the United States, NigerianAmericans employ protective factors such as ethnic identity and resilience to buffer the effects of acculturative stress and perceived discrimination on well-being and psychological distress. Regression analyses suggest some consistency with the …

Epithelial Responses To Porphyromonas Gingivalis In The Community Context., Zackary Ray Fitzsimonds

Electronic Theses and Dissertations

Porphyromonas gingivalis, a keystone pathogen for periodontal disease, initiates a complex molecular dialogue with gingival epithelial cells, leading ultimately to disruption of host signaling pathways. Dysbiotic host responses are also thought to contribute to the initiation and progression of oral squamous cell carcinomas. Recently, the homeostatic commensal Streptococcus gordonii has been shown to antagonize P. gingivalis-induced epithelial cell signaling events in host cells, such as proliferation and migration. The aim of this study was to characterize pathways that P. gingivalis targets to disturb host signaling, with a specific focus on pathways that S. gordonii can restore to homeostatic …

Practicing Pan-Africanism: West Indians And Governance In Kwame Nkrumah's Ghana., Nicholas C. Mcleod

Electronic Theses and Dissertations

After gaining independence from England, Kwame Nkrumah, the first President of Ghana, was transparent in his embrace of the entire African diaspora and actively recruited a number of Pan-African West Indian intellectual-activists, who mentored and advised him as a student in London, to help build Ghana as a Pan-Africanist state. Among these West Indian intellectual-activists were George Padmore, W. Arthur Lewis, T. Ras Makonnen, and Jan Carew. For these West Indians the appeal of Ghana was neither symbolic nor ceremonial, but rather an opportunity to achieve the ultimate objective of the Pan-African movement, a free and self-governed African continent. In …

Identification And Structural Characterization Functional Motifs In The Porphyromonas Gingivalis Mfa1 Short Fimbria., Mohammad K. Roky

Electronic Theses and Dissertations

Porphyromonas gingivalis is a causative agent of periodontal disease, initially colonizes the oral cavity by adhering to commensal streptococci. Adherence requires the interaction of the minor fimbrial protein (Mfa1) of P. gingivalis with streptococcal antigen I/II (Ag I/II). A peptide derived from Ag I/II peptide has been well characterized and shown to significantly reduce P. gingivalis colonization and bone loss in vivo, suggesting that this interaction represents a potential target for therapeutic intervention. However, the functional motifs of Mfa1 involved in the interaction with Ag I/II remain uncharacterized. A series of N- and C-terminal peptide fragments of Mfa1 were …

The Sidewalk Less Traveled: Evaluating Change In Community And Police Perception., Jennifer Lee Hall

Electronic Theses and Dissertations

For a police department to provide efficient and effective services to the community, they must obtain the support of the public, continuously cultivating and maintaining positive perceptions from the citizens being served. Various methods, such as walking patrols, have been implemented to increase public support and trust in police, which, in turn, contributes to a cooperative relationship between community and law enforcement. When opinions of law enforcement are precarious or police departments fall out of favor with the surrounding community, police officers can feel isolated if their work is unsupported. This often leads to the development of a strong bond …

Women Of Pop., Jourdan Cunningham

Electronic Theses and Dissertations

The hegemonic values that were represented in 1960s mass media were heavily reinforced by the Pop Art movement. Male Pop artists have often been viewed as genius, while the women were pushed aside to reside within the margins of the Pop canon. This thesis emphasizes the work of four female artists who participated in the Pop Art movement and were largely overlooked throughout Pop’s discourse. By analyzing their “popness” and Feminist viewpoints, it allows for the imbalance that has resulted from women Pop artists neglect throughout Pop’s discourse to be readdressed. In the Introduction I analyze the background of the …

Identifying Competencies And Outputs Of Sss Role In Stem Bridge Programs In The Silicon Valley, Alexandra C. Duran

Electronic Theses and Dissertations

This study identified the competencies and outputs associated with the role of student support specialists (SSS) in science, technology, engineering, or mathematics (STEM) bridge programs in the community colleges of Silicon Valley. The growth of STEM education, coupled with the increasing diversity of student population in community colleges, has made the work of SSS professionals in the region challenging. While the SSS professionals are often positioned as comprehensive, nonacademic support for STEM students, not enough has been documented on the competencies and outputs associated with SSS role in STEM bridge programs. In addition, most studies on student affairs professionals primarily …

Cluster Analysis Of Opioid Accessibility In The Carolinas Using Data From The Arcos Database And An Enhanced Two-Step Floating Catchment Area Method, Michael T. Bunker

Electronic Theses and Dissertations

This study takes advantage of transaction level data from the U.S. Drug Enforcement Administration's (DEA) Automation of Reports and Consolidated Orders System (ARCOS) database made newly available under court order by The Washington Post in July 2019. This data details individual shipments of pharmaceutical opioid analgesics from wholesalers to retail distributors. Using the Enhanced 2-Step Floating Catchment Area (E2SFCA) method, this study calculated access to opioid morphine milligram equivalents (MME) per capita for census tracts in North Carolina and South Carolina during the year 2009. This study demonstrated that outlier volumes of opioid analgesics at individual pharmacies are not always …

A School-Based Sexual Health Education Program, Tracy L. Kendall

Electronic Theses and Dissertations

A small rural community has high incidence rates of chlamydia (4,751 per 100,000) and gonorrhea (970 per 100,000) in females 15–24 years old. Data obtained from Texas Health and Human Services showed that incidence rates of chlamydia and gonorrhea in females 15–24 years old were higher in Navarro County, Texas, than the state of Texas. Texas schools do not mandate sex health education. There is a gap in school-based sexual health education available to 18- and 19-year-old females residing in this rural community in Texas. The purpose of this research study was to evaluate the impact of school-based sexual health …

The Relationship Between Exclusionary Discipline, Race, Socioeconomic Status, And Graduation Rates At 4a, 5a, And 6a High Schools, Ryan M. Cavazos

Electronic Theses and Dissertations

High school graduation is a significant predictor of future success. In most cases, a high school graduate will earn more money and live a healthier lifestyle than those who do not graduate from high school. The graduation rate in the United States is lower than the graduation rate of many other industrialized countries. Three known predictors of graduation rate are the number of exclusionary discipline assignments a student incurs, the race of the student, and the socioeconomic status of the student. The purpose of this study was to determine the relationship between graduation rate, exclusionary discipline, race (nonwhite), and low …

Academic Success And Curricular Structure: Exploring The Relationship Between Prerequisite Course Sequence And Grade Point Average In Community College Health Science Students, Patrick Carl Dupont

Electronic Theses and Dissertations

The current and ongoing shortage of healthcare professionals in the United States challenges educators and institutions to produce graduates of health professions programs in ever-increasing numbers. However, the current process typically used in community colleges is a cafeteria-style system of open enrollment, a model in which students pick courses from many choices without guidance or counseling. As a result, students often enroll in more advanced courses before taking the fundamental science courses. This may lead to poor performance, dropout, or failure. One potentially important variable in student success at a community college in the southwestern United States is student performance …

Increased Access To Information Communication Technologies And Work-Life Balance With K-12 Leaders, Carolyn D. Washington

Electronic Theses and Dissertations

This qualitative study describes the lived experiences of kindergarten through 12th-grade leaders (K-12) relative to the increased accessibility of information communication technology (ICT) and work-life balance (WLB). Technology has evolved and become more accessible in the 21st century in individuals’ personal and professional lives. Research has shown the impact of ICT in other high demanding professions, with little research available relative to the impact with K-12 leaders. However, the role of the K-12 leader is likewise considered highly demanding with extended work hours. The K-12 leader is responsible for the day-to-day activities of the principalship, being available after hours for …

Folk Music Of Atlantis: An Exploration Of Water As A Sound Source In Music, Lucy Jackson

Electronic Theses and Dissertations

Folk Music of Atlantis is a programmatic composition for water instruments and orchestra depicting the mythical city of Atlantis. I have researched water’s musical properties: its pitch bending, its ability to create sound through motion, and its percussive effects on various materials. Drawing upon my research, I have invented a collection of water-based instruments that take advantage of these properties. Folk Music of Atlantis demonstrates their potential, combining them with both the traditional orchestra and the innovations in water music of past composers.

The written portion of the thesis includes a historical overview of water as a musical sound source, …

A Rhetoric And Philosophy Of Gifts, Mary Eberhardinger

Electronic Theses and Dissertations

This project synthesizes a selected scope of rhetorical and philosophical perspectives of the gift. The research question is what the relationship between gifts and rhetoric might be. In order to approach this question, this project offers a review of related literature on the topic of gifts. It then provides analysis and discussion that contextualize the question. The project finally concludes by offering implications. The implications address why the question concerning the relationship between gifts and rhetoric matters for the larger landscape of international relations.

Friendship In The Digital Age: Implications From A Philosophy Of Communication Approach, Tiffany Petricini

Electronic Theses and Dissertations

Friendship is a central relationship-style that grounds us. Much of the literature on the effects of technology on our relationships, especially friendship, has taken a skeptical approach. The notion of friendship is historically-situated, thus, it requires attention in each era and has prompted questions throughout human history. Our time is no exception. Changing cultures and redefinitions of basic human institutions have led us to our current moment, in which we are experiencing a loud and continuing debate on the effect of technology on our lives. Advancements in science have allowed us to understand our past and present in new ways. …

Evaluating An Evidenced Based Program: Ruling Our Experiences (Rox) For 9/10-Year-Old Girls In The Yough School District, Lisa Mumau

Electronic Theses and Dissertations

During elementary school years, girls experience social, emotional, and physical changes that affect their abilities to manage relationships and establish positive images of themselves. Given the aforementioned issues, girls need effective elementary school programming to support positive self-esteem and the development of girls’ Social Emotional Learning (SEL) Competencies. The purpose of this mixed-method study focused on evaluating the Ruling Our Experiences (ROX) program for 9/10-year-old girls. The methods used were designed to address the three research questions: Based on the implementation of the ROX program in Yough elementary schools, to what extent do participants exhibit a greater level of positive …

Apparatgeist And Mobile Communication: Considering Interpersonal Communication Practices, Lisa Enright

Electronic Theses and Dissertations

Mobile communication is embedded into our daily life increasing our connection to social networks. The development of mobile communication occurred during the second half of the twentieth century and has become domesticated into everyday life. One consequence of the widespread adoption of mobile communication device use is an increase in connectivity. This increase in connection has led to a shift in interpersonal relationships. People now must be aware of when to connect and disconnect to develop meaningful relationships in private, public, and social realms. This project seeks an understanding of how the consequence of increased connectivity and the development of …

Agency, Identity, And Authority In Rwanda: 1950s Political Rhetoric As A Bridge To Post-Colonial Genocide, Amanda E. Rollinson

Electronic Theses and Dissertations

During the Rwandan genocide, Hutu targeted Tutsi and allies. Interpreting this complex event requires examining the late 1950s. Analyzing Tutsi and Hutu in central Rwanda in 1957 improves understanding of political and social context preceding the genocide. This study rejects that the genocide occurred as an inevitable event. Instead, it layers domestic actors with international groups: the White Fathers missionaries; the United Nations; Belgium; and the United States. Analyzing each group and synthesizing their interactions elevates Rwanda’s history from the falsehood of ancient adversaries to a complex, modern narrative. Studying Rwandan rhetoric and responses to it provides an opportunity to …

Exploring And Re-Envisioning The Significance Of Agrarian Consciousness In Theology With Specific Reference To Kerala, Jinto George

Electronic Theses and Dissertations

Globalization has a great impact on present-day society. Everything and everyone relates to each other based on market value. The commodification of agriculture and food has led the world into a situation where one lacks intimacy and bond in the relationship. The impact of globalization has influenced the present Kerala community. The monocultural systems of globalization have influenced the community which has led the Kerala society into a commodified society. The commodification of agriculture and food has influenced the patterns of relationships in the Kerala society, especially in their ecological, human, and spiritual relationship.

God did not create a world …

The Physiology And Evolution Of Selenite Respiration In Bacteria, Michael Wells

Electronic Theses and Dissertations

The selenium oxyanions selenate (Se(VI)) and selenite (Se(IV)) can be utilized by some bacteria and archaea as terminal electron acceptors in anaerobic respiration. Se(VI) and Se(IV) respiration is mediated by a phylogenetically and ecologically diverse array of organisms, suggesting that selenium respiration is ubiquitous in natural environments. Several respiratory Se(VI) reductases have been characterized in bacteria, revealing that Se(VI) respiration has evolved independently several times in this domain. Se(IV) respiration, in contrast, has yet to be characterized. I have purified and characterized the first respiratory Se(IV) reductase from Bacillus selenitireducens MLS10. The Se(IV) reductase appeared to purify as a single …

Gene Delivery To The Blood-Brain Barrier For Ischemic Stroke Therapy, Wanzhu Zhao

Electronic Theses and Dissertations

Stroke is a major cause of death in the United States. We aim to develop safe and efficient approaches for the treatment of stroke. Regenerative therapies have been identified as the major need for curing stroke [1]. We explored two different carriers (poly (ethylene glycol)_5k-poly (L-aspartate-diethylenetriamine)₄₈ (PEG-DET) / Pluronic P84 (P84) and exosomes (EXOs) / microvesicles (MVs)) to deliver brain-derived neurotrophic factor (BDNF) plasmid DNA (pDNA), a functional gene encoding a neurotrophin. In the first project, our data showed that DNA nanoparticles (NPs) with 0.03% P84 was a promising formulation to deliver Luciferase pDNA into immortalized human …

St. Ignatius' Quill Pen: Exploring The Orality-Literacy Difficulty In The Spiritual Exercises, Hongchao Qian

Electronic Theses and Dissertations

Informed by the work of Walter Ong, in the first prelude of the First Week in the Spiritual Exercises, St. Ignatius of Loyola used an emblematical image, the “prison-cage”, to provide phenomenological accounts for the exercitants to examine the existential situation within. This dissertation explores into the difficulty of being rhetorical in mediating on the existential situation emblematically. I try to understand the orality-literacy dynamic within the Exercises through the theoretical framework of semiotic phenomenology. The Ignatian emblematics can be understood as phenomenological descriptions that asked the exercitants to provide the parts of moral-phenomenological reductions and phenomenological interpretations within …

Using Point Of View Video Modeling To Teach Math To Students With Autism Spectrum Disorder In Saudi Arabia, Hamad Hamdi

Electronic Theses and Dissertations

The utilization of academic skills plays a significant role in an individual’s function in society. For countries who are still developing an effective base of evidence-based practices, such as Saudi Arabia, single-subject research can be a powerful tool in discovering best practices for students with autism spectrum disorder (ASD). The purpose of this study was to determine the effectiveness of point-of-view video modeling (POVM) in improving the math skills (addition with regrouping) of elementary participants with ASD. A multiple baseline across participants design was used to examine the effectiveness of the intervention on each participant’s ability to solve two-digit by …

The Effects Of Teacher Professional Development And Self-Efficacy On Classroom Uses Of Information And Computer Technologies, Elif N. Gokbel

Electronic Theses and Dissertations

The uses of new technologies during mathematics instruction are essential for maintaining opportunities for students to gain better understanding of the content and become digital learners in the information age. Although scholars found technology integration is helpful in improving students’ mathematics achievement, the role of teachers’ preparedness for technology integration remains critical.

Technology professional development and self-efficacy are two major factors impacting teachers’ successful integration of instructional technologies. The purpose of this study was to provide a more in-depth look into (i) mathematics teachers technology uses during direct instruction, dialogic instruction, and assessment; (ii) the relationship between various types of …