Digital Commons Network^™

The Role Of Ehd2 In Endothelial Cells, Rachael Judson

Electronic Theses and Dissertations

The role of EHD2 in terms of Cav1 interaction had not been previously characterized and was the main goal of this research. Cav1 has been shown to lead to the ubiquitination of Rac1. Because of this, the role of EHD2 in Rac1 regulation was investigated. An increase in long-term migration in endothelial cells was observed and suggested that EHD2 impacts the RhoA pathway instead of the Rac1 pathway. This lead to the hypothesis that EHD2 controls a part of the RhoA pathway. This hypothesis is supported by the loss of filamentous actin and an increase in serrated junctions in cells …

Exploring The Potential For Therapeutic Art-Making In School Psychology Practice: A Single Case Study Of A Training Experience, Alexandra G. Manion

Electronic Theses and Dissertations

The purpose of this study was to investigate the impact of a training experience on the use of therapeutic art-making for school psychologists, with a focus on how to incorporate these concepts into their school-based mental health practice. Therapeutic artmaking includes the use of visual art activities (drawing, painting, clay, and collage) with specific therapeutic intent. Although there are examples of art therapists providing inschool therapeutic art-making services to support the mental health needs of students, there is far less information regarding the use of therapeutic art-making by school-based mental health providers, including school psychologists. This single case study explored …

Going Backstage: Examining Justice Perceptions Of Electronic Performance Monitoring, Maurice Harris

Electronic Theses and Dissertations

Organizations are rapidly adopting emerging technologies, popularly known in the media as “bossware,” that track the behaviors of employees. The use of these technologies to monitor worker performance is known as electronic performance monitoring (EPM) in the academic literature. EPM systems increasingly utilize advanced algorithms, equipping companies with the capabilities to expose employees' actions, thoughts, and feelings. Prior research on EPM has focused mainly on the reactions of front-line workers, ignoring the perceptions of employees who work at different hierarchical levels within their organizations. An organizational justice perspective is used to examine how a company’s decision to grant employees the …

Characterization Of Cyclopropyl Synthases Involved In The Maturation Of Ribosomally Synthesized And Posttranslationally Modified Peptides, Yi Lien

Electronic Theses and Dissertations

Ribosomally synthesized and post-translationally modified peptides (RiPPs) are a large class of natural products with significant human health implications. RiPPs are synthesized from a genetically encoded precursor peptide that undergoes significant modifications by maturing enzymes, or maturases. Recently, radical-S-adenosylmethionine (rSAM) enzymes have emerged as an important family of RiPP maturases. rSAM enzymes have been shown to install ether, thioether, and carbon-carbon bonds on the precursor peptide. These modifications usually define the backbone structure of the mature RiPP. This thesis describes the characterization of a novel RiPP modification catalyzed by the radical S-adenosylmethionine enzyme TigE. TigE belongs to the TIG biosynthetic …

Mia San Mia: Professional Club Soccer, Religion, And Social Ethics, Rebecca A. Chabot

Electronic Theses and Dissertations

For thousands of soccer fans around the world, soccer is their religion. This dissertation marks the first extended examination of what religious soccer is, what it looks like in practice, and how it impacts the lives of fans in the context of professional club soccer. It provides a framework for non-fans to understand how religious supporters view the game and addresses major moments in the development of soccer throughout the world, paying special attention to the difference between the United States and the rest of the world. Religious soccer is then explored in depth, drawing on ethnographic research with over …

Could Alexa Increase Your Social Worth?, Peter Tripp

Electronic Theses and Dissertations

People have historically used personal introductions to build social capital, which is the foundation of career networking and is perhaps the most effective way to advance a career (Lin, 2001). With societal changes, such as the pandemic (Venkatesh & Edirappuli, 2020), and the increasing capabilities of Artificial Intelligence (AI), new approaches may emerge that impact societal relationships. Social capital theory highlights the need for reciprocal agreements to establish the trust between parties (Gouldner, 1960). My theoretical prediction and focus of this research include two principles: The impact of reciprocity in evaluating trust of the source of the introduction and the …

An Intersectional Perspective On The Role Of Workplace Policy Among Employed Female Caregivers During The Coronavirus Pandemic, Jessica King Mclaughlin

Electronic Theses and Dissertations

Providing care for an older adult while working can be challenging, often leading to caregiver burden. The socioenvironmental context of the coronavirus pandemic creates additional complications for working caregivers. Women, who are the majority of informal caregivers, face unique stressors in the workplace (McKinsey & Company, 2019; Carnevale et al., 2018). Prior to and during the coronavirus pandemic, workplace policies have offered the potential of support, yet more information is needed on how working female informal caregivers of older adults of diverse identities receive, interpret, and experience these policies amidst the context of the pandemic. This study uses a phenomenological …

Exploring Youth Relationships With Nature Using Qualitative Gis, Corey J. Martz

Electronic Theses and Dissertations

Understanding youth relationships with nature—what nature is, where nature is located, and why nature is meaningful—is important for a range of contemporary issues, from promoting health and well-being to advancing a sustainable future. Relationships with nature are profoundly influenced by the lived experiences of youth, as they form social connections, have fun, learn, and go about their lives across an array of places—residences, schools, trip destinations, and places in between. One key to exploring youth relationships with nature, therefore, is engaging youth to document their experiences of nature in relation to specific places and developing methods that support them to …

Digital Searching: A Grounded Theory Study On The Modern Search Experience, Nicolas Armando Parés

Electronic Theses and Dissertations

This Grounded theory study explores US adults' modern information search process as they pursue information through digital search user interfaces and tools. To study the current search process, a systematic grounded theory methodology and two data collection methods, a think-aloud protocol and semi-structured interviews, are used to develop the theory. The emerging theory addressed two tightly connected research questions that asked, “What is the process by which humans search and discover information?” and “What is the process by which search and discovery interfaces and tools support the modern search process?”

The study collects participant data from US adults who have …

Understanding And Supporting Asian American Youth’S Mental Health Within Cultural And Family Contexts, In Young Park

Electronic Theses and Dissertations

Mental health problems are a major health issue among East Asian American (EAA) youth. Although previous research has explored the risk and protective factors associated with mental health problems of EAA youth, many studies have employed Eurocentric perspectives, thereby excluding their unique cultural backgrounds, beliefs, and values. To better understand mental health needs and support these youth, further research that identifies different factors associated with mental health problems in their cultural context and assesses evidence-supported and culturally responsive interventions is needed.

This three-manuscript dissertation is presented in three papers. The first manuscript presents an integrative conceptual framework that uses two …

Inhibition Of De Novo And The Prion-Like Spread Of Amyloidogenesis Using In Vitro And In Vivo Disease Models, Johnson Anazoba Joseph

Electronic Theses and Dissertations

The aberrant fibrous, extracellular, and intracellular proteinaceous deposits in cells, organs and tissues are referred to as amyloids. These deposits are dominated by β-sheet structures that have been implicated in several neurodegenerative diseases and cancer. In this work, the types of amyloidosis studied include Parkinson’s disease (PD) using UA196 and NL5901 strains of Caenorhabditis elegans (C. elegans), Alzheimer’s disease (AD) using GMC101 strain of C. elegans, and cancer-associated mutant p53 aggregation in MIA PaCa-2 mutant cells. Several molecules including SK-129, NS132, NS163, bexarotene, a polyphenol (-)-epi-gallocatechine gallate (EGCG), ADH40, RD148, and RD242 were screened in vitro and in …

Working Here, There, And Everyware: The Impact Of Virtual Work On Employee Belonging, Martha Davis

Electronic Theses and Dissertations

Globalization, improvements in information and communications technologies, and the COVID-19 outbreak have increased the prevalence of virtual work arrangements. This change in the workforce presents both opportunities and challenges to employees and their organizations, transforming how organizations operate and how workers interact with each other. This shift to more virtual work has a high likelihood of impacting other fundamental human motivations, such as the need to belong, which has significant implications for an employee’s well-being and the broader organization’s health. This study asks the question: How do collaborative technologies impact virtual employee belonging? The study proposes a conceptual framework of …

Directly Polymerizable Co Releasing Molecules, Jackson Snow

Electronic Theses and Dissertations

Despite the commonly held consensus that carbon monoxide (CO) is toxic, it has been shown to be an essential signaling molecule in the human neuronal system and has been noted to have anti-inflammatory properties, act as a vasodilator, have anti-proliferative impacts on tumors, and many other beneficial effects. The current limitation to using CO as a therapeutic molecule is delivering the proper dosages using CO releasing molecules (CORMs) without exhibiting toxicity. The first chapter of this thesis will review the biological significance of CO in biological systems, the limitations of existing CORMs, and the properties of diphenylcyclopropenone (DPCP) that make …

Humanizing Computational Literature Analysis Through Art-Based Visualizations, Alexandria Leto

Electronic Theses and Dissertations

Inequalities in gender representation and characterization in fictional works are issues that have long been discussed by social scientists. This work addresses these inequalities with two interrelated components. First, it contributes a sentiment and word frequency analysis task focused on gender-specific nouns and pronouns in 15,000 fictional works taken from the online library, Project Gutenberg. This analysis allows for both quantifying and offering further insight on the nature of this disparity in gender representation. Then, the outcomes of the analysis are harnessed to explore novel data visualization formats using computational and studio art techniques. Our results call attention to the …

Exploring The Relational Impact Of Breast Cancer On Younger Women Partnered With Women, Kaitlin V. Ross

Electronic Theses and Dissertations

Approximately 268,600 new cases of breast cancer in women are diagnosed each year in the United States. Due to improvements in cancer detection and treatment, survivorship is higher than in the past. More than ten percent of new diagnoses are in women 45 years or younger. There are approximately one million sexual minority individuals living with cancer in the US, yet this population is understudied in cancer care. For sexual minority women with breast cancer, sociocultural factors such as lack of affirmative care influences their disease experience. Further, sexual minority women and women partnered with women may be subject to …

Puerto Ricans And Asthma: Looking Through The Lens Of Historical Trauma, Lisa Colón

Electronic Theses and Dissertations

This study utilized an explorative phenomenological qualitative design to begin understanding the many ways Puerto Ricans experience asthma. Further is sought to understand the asthma experience broadly and within the context of the hurricanes that devastated Puerto Rico in 2017 including the governments’ responses to that devastation. Another core goal of this study was the conceptual and empirical application of the theoretical framework of historical trauma to Puerto Ricans. I conducted 12 semi structured interviews with collaborators who expressed a range of asthma experiences. My collaborators represented a mixture of those who lived through the hurricanes in Puerto Rico and …

Where Virtual Well-Being Becomes Reality, Colleen M. Reilly

Electronic Theses and Dissertations

Strategies to mitigate the spread of COVID-19, specifically quarantine and social distancing protocols, have exposed a troubling paradox: mandated isolation meant to save lives has inadvertently contributed to a decline in America’s well-being. Prolonged isolation due to more remote work and decentralized workplaces has been associated with widespread loneliness and diminished physical and mental health, with effects compounded by limited face-to-face access to social support systems. While remote communication technologies (e.g., video chat) can connect individuals with colleagues and social networks, remote technologies might have limited effectiveness in business and social contexts. This study uses Roger’s Diffusion of Innovation Theory …

Trans And Genderqueer Military Service Member-Veterans: An Acculturation Phenomenology Of Civilian Reintegration, Joseph A. Galluzzo

Electronic Theses and Dissertations

As United States military policy continues to evolve and affirm the accession and retention of trans and genderqueer (TGQ) service members, more TGQ people will join and ultimately separate from military service. Reintegration is a term that represents the experience of beginning to separate from the military and transitioning into civilian life, and those who encounter it are referred to as military service member-veterans (MSMVs). Though empirical knowledge of reintegration for MSMVs overall continues to improve, cultural relevance has only recently been considered, and no research has investigated the reintegration experiences of TGQ MSMVs specifically. The primary purpose of this …

Measurements Of Atmospheric Radicals, Heather L. Runberg

Electronic Theses and Dissertations

Atmospheric particulate matter (PM) is a global health concern. PM_2.5 is formed primarily through combustion processes such as automobile use and industrial activity. Natural sources of PM_2.5 result from events like volcanos and wildfires. Upon inhalation, PM_2.5 is small enough to travel deep into the lungs where it can form reactive oxygen species (ROS), such as hydroxyl radical (OH), causing oxidative damage to pulmonary tissues. PM_2.5 has been linked to cardiopulmonary diseases such as asthma, chronic obstructive pulmonary disease (COPD), and high blood pressure.

PM_2.5 is small enough to remain aloft and travel many hundreds …

Outdoor Early Intervention Services: Current Practices And Future Directions, Tiffany Lee

Electronic Theses and Dissertations

Outdoor play is a crucial in supporting child development, resiliency, social skills, creative thinking, adaptability, family growth, and family engagement. Unfortunately, children are spending less time outside because of technology, parent fears, and other factors. Parents who have a child with a disability have even more challenges when it comes to playing outside. Thus, children with disabilities are spending even less time in outdoor environments. Early Intervention (EI) is a program that is designed for infants and toddlers between the ages of zero to three that have developmental delays and/or disabilities. EI uses a family-center approach in natural environments to …

A Labor Of Love: Extensive Exploitation Of Contract Music Workers, Malia Odekirk

Electronic Theses and Dissertations

Workers across the United States are reckoning with unfair labor conditions by unionizing and speaking out. Systemic undervaluing of many workers has created a climate of fear, hidden agendas, and pervasive labor misconduct. The pageantry/marching arts are no exception. As a cultural insider, I conducted interviews, had many informal conversations, and ran a large survey that uncovered how the marching arts exploit instructors extensively despite their experience, education, and efforts. A systematic proclivity toward late payments, abused contracts, egregiously low compensation, and free labor begs the question: how can programs continually mistreat instructors this way? I explore this question through …

Tech-Savvy School Principals Leveraging Crisis Leadership To Support Teaching And Learning In Their Schools Through Covid-19 Pandemic, Mohsen Alzahrani

Electronic Theses and Dissertations

The purpose of this exploratory case study was to learn about the effective practices that recognized tech-savvy principals enacted to support teaching and learning in their schools during the first academic year of the COVID-19 crisis. The study involved semi structured interviews with five recognized tech-savvy school principals. It also involved analyzing supporting materials and documents.

The findings of this study indicated that tech-savvy principals were not stuck in the structural rut that most principals found themselves in during the COVID-19 crisis. Four main themes emerged from the data. The first theme addressed how recognized tech-savvy principals demonstrated decisive decision …

Evaluating The Impact Of Individual And Couple Relationship Education On Postpartum Depression, Maggie O’Reilly Treter

Electronic Theses and Dissertations

This dissertation evaluated the impact of relationship education on postpartum depression using data from two randomized controlled trials of relationship education for individuals and couples who were pregnant or recently had a baby. Paper 1 focused on a well-established relationship education program for low-income couples in Oklahoma City, Family Expectations. Key findings from Paper 1 demonstrated that being randomized to Family Expectations was associated with lower odds of experiencing depression in the first 12 months after having a baby among both mothers and fathers, though this effect was only marginally significant, and that the program had the strongest impact among …

Crafting Up A Narrative: An Ethnographic Study Of Fair Trade Marketing Practices And The Representation Of Female Handicraft Producers, Jessica Bradley

Electronic Theses and Dissertations

Unlike the exploitative supply chains that exist under neoliberal globalization, where the social conditions of their supply chain are largely hidden; fair trade attempts to reveal the conditions of their supply chains through transparent marketing practices. Transparency is often presented in the form of storytelling wherein fair trade organizations (FTOs) reveal intimate details of the artisans they partner with to educate consumers on the interrelations of their product supply chains. I wanted to explore the implications of sharing artisan stories to further sales of the handicrafts they produced. How does sharing intimate stories of artisans formulate the perceptions Western consumers …

Morphological Variation And Community Science In Orthoptera, Amy Byerly

Electronic Theses and Dissertations

Patterns of morphological divergence across species’ ranges provide insight into local adaptation and speciation. Here, we compare phenotypic divergence among 4,221 crickets from 337 populations of two related species of field cricket, Gryllus firmus and G. pennsylvanicus and their hybrids. We find that these species differ across their geographic range in key morphological traits, such as body size and ovipositor length, and we directly compare phenotype with genotype for a subset of crickets demonstrating nuclear genetic introgression, phenotypic intermediacy of hybrids, and essentially unidirectional mitochondrial introgression. We discuss how these morphological traits relate to life history differences between the species. …

The Genuine Alacrity Of Things, Evelyn Hampton

Electronic Theses and Dissertations

“The Genuine Alacrity of Things” is a short story collection. Themes include personal identity, the Anthropocene, grief, family, and relationships. The story collection is introduced by a critical introduction.

Organellar Zn2+ Homeostasis And The Role Of Trpml Channels In Neuronal Lysosome Physiology And Axonal Transport, Taylor Franklin Minckley

Electronic Theses and Dissertations

Zinc (Zn²⁺) is crucial for proper cellular function, and as such it is important to measure and track Zn²⁺ dynamics in living cells. Fluorescent sensors have been used to estimate Zn²⁺ content of subcellular compartments, but little is known about endolysosomal Zn2+ homeostasis. Similarly, although numerous sensors have been reported, it is unclear whether and how Zn²⁺ can be released from intracellular compartments into the cytosol due to a lack of probes that can detect physiological dynamics of cytosolic Zn²⁺. My dissertation started with comparing and characterizing different Zn²⁺ sensors including the …

Executive Function And Parenting Among Latinx Caregivers Of Young Children, Amy Dominguez Fabatz

Electronic Theses and Dissertations

Supportive and responsive parenting is vital to the healthy development of young children. Parenting behaviors are determined by many factors, including caregivers’ cognitive resources and abilities such as executive functioning (EF). The present study investigated how two core dimensions of EF, working memory and set-shifting abilities, are related to parenting behaviors in a sample of Latinx caregivers of young children experiencing low income. Positive parenting was measured using a multi-method approach including video-coded observations, parent self-report, and evaluation of the home environment. Findings from hierarchical regressions indicated that caregiver working memory, but not set-shifting, predicted positive parenting as measured by …

Dismantling The Education-Survival Complex: A Qualitative Case Study Of How High School Youth Resist Whitestream School Policies And Foster School Change Through A Youth-Development Organization, Tracie Trinidad

Electronic Theses and Dissertations

The aim of this study is to critically examine how youth resist whitestream school policies and foster educational change through community sociopolitical youth-development organizations. The methodology for this study is a qualitative case study (Fraenkel & Wallen, 1990; Merriam, 1988), as I am focused on participant perceptions and experiences, and how they make sense of their resistance experience through participation in sociopolitical youth development organizations like Youth for Social and Political Activism (YSPA). In total, eight participants spoke about their racial identity through their lived experiences in public school and YSPA programming.

The data and analysis are presented in the …

Faculty Facilitation Of Help-Seeking On Campus: A Phenomenological Study, Lillian V. Clark

Electronic Theses and Dissertations

An ever-increasing number of students on college campuses are experiencing distress, and not all students in need of care are being reached (Kitzrow, 2009, LeViness, et al., 2019). Faculty are one of the most valuable resources for identifying and connecting students to care (Kitzrow, 2009). Despite this, we know very little about the experiences of faculty working with students in distress. This study sought to understand those experiences, as well as identify the barriers to connecting students to care. A qualitative study using an Interpretive Phenomenology framework was conducted (Smith & Osborn, 2007, Moustakas, 1994). Four themes were interpreted from …