Digital Commons Network^™

Tau Aggregation, Conformational Selection, And Inhibition, Michael R. Holden

Electronic Theses and Dissertations

Tau fibrils are a pathological hallmark of over 20 neurodegenerative disorders, including Alzheimer's disease. There currently is no cure for these diseases and treatments are limited. Once Tau fibrils form in the brain, they propagate down neuronal networks, and this spreading is linked to disease progression. Studying the behavior and structure of Tau monomer and Tau aggregates therefore may give insight into methods by which the spread of Tau fibrils can be inhibited. The structures of the Tau fibrils from different diseases are thought to vary, partially giving rise to the different disease phenotypes. Tau natively binds to microtubules by …

Tides Of Cooperation: The Ebb And Flow Of Regional Cooperation In Latin America, Amaleia E. Kolovos

Electronic Theses and Dissertations

Regional organizations have developed into important global actors as they negotiate inter-regional trade agreements, regulate economic policies, and develop international security communities. States have much to gain from such regional cooperation efforts particularly in emerging regions such as Latin America. Such gains can include increased trade and economic relations, enhanced security, attracting external investment, and increasing bargaining power at the international level. With such gains to be had, one might expect states in these regions to regularly cooperate in order to achieve their common interests. However, this is clearly not always the case. Latin America has struggled for decades with …

The Whiteness Project Of Gentrification: The Battle Over Los Angeles' Eastside, Jaime Guzmán

Electronic Theses and Dissertations

For many years, the city of Los Angeles has declared war on communities of color. In the past decade, former communities of color like Echo Park, Silver Lake, and Highland Park have all been converted into predominantly white, affluent neighborhoods. In essence, working-class people of colors' neighborhoods are being uplifted in order to welcome a much more affluent population to town. The newest target of Los Angeles' gentrification for the past couple of years has been the greater Eastside. In this project I present my critical intervention of gentrification as a whiteness project. This critical intervention argues that gentrification …

Studying Facial Expression Recognition And Imitation Ability Of Children With Autism Spectrum Disorder In Interaction With A Social Robot, Farzaneh Askari

Electronic Theses and Dissertations

Children with Autism Spectrum Disorder (ASD) experience limited abilities in recognizing non-verbal elements of social interactions such as facial expressions [1]. They also show deficiencies in imitating facial expressions in social situations. In this Master thesis, we focus on studying the ability of children with ASD in recognizing facial expressions and imitating the expressions using a rear-projected expressive humanoid robot, called Ryan. Recent studies show that social robots such as Ryan have great potential for autism therapy. We designed and developed three studies, first to evaluate the ability of children with ASD in recognizing facial expressions that are presented to …

Social Conflict On The Seas: Links Between Overfishing-Induced Marine Fish Stock Declines And Forced Labor Slavery, Jessica L. Sparks

Electronic Theses and Dissertations

Despite media attention detailing labor abuses in fisheries, social-ecological systems research has largely failed to consider whether fish stock declines could be contributing to increases in forced labor slavery. Empirical fisheries data suggests, though not a ubiquitous response to declining stocks, many vessels will fish longer, farther from shore, and deeper in waters to maintain yields. This effort intensification increases production costs, and Brashares et al. (2014), consistent with slavery theory, posited cheap and/or unpaid labor as an approach to offset increasing costs and continue harvesting fish species at a rate otherwise cost-prohibitive.

Using fuzzy cognitive mapping - a participatory, …

Psychotropic Medications And Children: Perceptions Of Mental Health Professionals, Elinor Jane Brereton

Electronic Theses and Dissertations

This project explores mental health professionals' perspectives on the prescription of psychotropic medications to children. It emphasizes the placement of biomedicine within its larger social, economic, and political context, and the influence these structures have on the way mental illness is conceptualized and treated in children. Eight semi-structured interviews were conducted in Denver, Colorado with psychiatrists, psychologists, social workers, and a pharmaceutical board member to capture multiple perspectives from different positionalities within the field. Participants discussed factors that they believe influence prescribing practices including: professional role changes, issues of access, limited evidence, cost, and institutional pressures to practice within a …

A Phenomenological Inquiry Into The Racialized Experiences Of Southeast Asian American Community College Students, Varaxy Yi Borromeo

Electronic Theses and Dissertations

Southeast Asian American (SEAA) (e.g., Cambodian, Hmong, Lao, and Vietnamese) students' educational realities are often masked by assumptions that all Asian Americans are model minorities. However, SEAA students have also been racialized as deviant minorities to explain disparities faced by the community. Relatively minimal scholarship has explored how race and racism shape their experiences. In this study, AsianCrit provides a framework for exploring the racial realities of SEAA students in community college. Qualitative research methods were employed to explore in-depth the ways they experience race and racialization. Specifically, this study is a phenomenological exploration of their lived racialized experiences and …

Fact Vs. Fiction: Uncovering The Experiences Of Homeless/Street Youths' Involvement In Survival Sex, Amber R. Mcdonald

Electronic Theses and Dissertations

Youth involvement in trading/selling sex has become of concern for policy makers, scholars, and the general public in recent years (Cecchet & Thorburn, 2014; Hossain, et al, 2010; Pub L No. 106-386; Reid & Piquero, 2013; Sapiro, Johnson, Postmus, & Simmel, 2016; Shared Hope International, 2015). The behavior of trading/selling sex is defined dichotomously within the literature. One body of literature, employs the term "survival sex" when empirical work focuses on trading/selling sex among lesbian, gay, bisexual, transgender, or queer (LGBTQ) identified individuals or youth that are homeless (Greene, Ennett & Ringwalt,1999; Halcon & Lifson, 2004; Walls & Bell, 2011). …

Away From The End Of Motherhood: Sites Of Haunting In The Social Imaginary In Lemonade And The Handmaid's Tale, Julia Michele Fleming

Electronic Theses and Dissertations

This thesis analyzes the television series adaptation of The Handmaid's Tale, specifically the episode "A Woman's Place," and Beyoncé's Lemonade: A Visual Album. I argue that these cultural texts leverage representations of women's lived experiences to scrutinize contemporary American anxieties about motherhood and reproductive justice. Lemonade, a celebration of Black womanhood, presents a counterpoint to The Handmaid's Tale's preoccupation with white motherhood in way that speculates on the utopian potentials of a woman-centered society.

Using bell hooks' film analysis, Avery Gordon's "haunting," and Luce Irigaray's "mimicry," I examine two interconnected themes: feminist aesthetics and generational haunting. …

Through The Yoruba Lens: A Postcolonial Discourse Of Female Circumcision, Jennifer Quichocho

Electronic Theses and Dissertations

Despite the Western media attention and the critique of female circumcision in sub-Saharan Africa, few studies consider the local populations' traditions, values, and ideologies. Through the Yoruba Lens: A Postcolonial Discourse of Female Circumcision investigates female circumcision practices from a philosophical, Yoruba traditionalist perspective. African philosophy and religion provides an ideological foundation and helps reveal the postcolonial and feminist theoretical framework that continues the academic debate. Framed by LeCompte and Schensul's notion that "ethnography emphasized discovery; it does not assume answers" (2010: 33), my research draws from literature reviews, quantitative data, and interviews. I will present and investigate three hypotheses …

The Foundations Of Aleksandr Dugin's Geopolitics: Montage Fascism And Eurasianism As Blowback, Grant Scott Fellows

Electronic Theses and Dissertations

This thesis is an examination of Aleksandr Dugin's The Foundations of Geopolitics, of which I have translated important sections into English and these are included as an appendix. Despite the importance of Foundations of Geopolitics to Russian strategic thought there has not been a translated edition published in English. This work was published in 1997 and has been quite influential for Russian political and military leadership. I strive to provide context for the setting in which Foundations of Geopolitics was created through an analysis of the social and political conditions that existed in Russia while the text was being …

Patient-Specific Quantification Of The Relationship Between The Left Atrium Pressure And The Ostial Diameter Of The Left Atrial Appendage, Sky Tianqi Gao

Electronic Theses and Dissertations

The left atrial appendage has been a historically understudied region of the heart until fairly recently with the new understanding of its role in the stroke pathway of patients with atrial fibrillation. The goal of this study is to take a look at the biomechanical behavior of the left atrium and left atrial appendage under normal physiological loading conditions using material properties taken from biaxial stretch tests. Several different options for material properties models were tested and biaxial stretch test data of cadaveric human tissue samples for the left atrium and appendage were fit to a Fung-type strain-energy function for …

A Critical Interpretation Of Olivier Roy: On Globalization, The Cosmopolitan And Emerging Post-Secular Religiosities, Joshua Rey Ramos

Electronic Theses and Dissertations

My thesis is that secularization transforms religion into religiosity. In other words, the secular breaks apart religion, or rather, 'deculturates' religion from a cohesive, collective body embedded within a particular society and within a traditional culture towards an individuated, and existential experience of faith within the autonomous religious subject. There are various reasons for this shift, as there are various consequences. Globalization, which is modernization writ large, is the dominant paradigm through which I conceptualize these changes. The theorist whose work I use as a lens to interpret secularization, religion and societal transformation is Olivier Roy. Roy's theories are of …

Curricular Agency: Contemplating Curriculum As A Process To Empower Teachers, Matthew L. Spurlin

Electronic Theses and Dissertations

Using the qualitative method of Educational Connoisseurship and Criticism (Eisner, 1991) and an interview structure based on the commonplaces (Schwab, 1969), this study involved working with four exemplary teacher educators to externalize their internal process of curricular decision-making. Contemplating their own curricula as a dynamic process rather than a finished product, the study identifies where in that process their curricular agency—their educational agency, and their human agency (Bandura, 2006)—is found. This operationalization of curricular agency within curricular theory provides an empowering perspective of teacher-centered education as a response to teacher burnout.

Curiosity And Gifted Identification: A Mixed Methods Study, Cameron Hays

Electronic Theses and Dissertations

This dissertation was designed to explore the link between epistemic curiosity and giftedness, in order to provide an additional potentially non-biased assessment to contribute to gifted identification "body of evidence" files for underrepresented and underserved populations. Students of color and students of lower socio-economic status are less likely to be placed into gifted and talented enrichment programs (Donovan & Cross, 2002). If a significant relationship is found between high curiosity and students who benefit from gifted education, psychometric instruments used for measuring curiosity could be invaluable in placing students in appropriate educational environments.

The study used a mixed methods design …

Now You See Me: A Black Feminist Autoethnographic Poetic Polemic Of Radical Reflexivity And Critical Arts-Based Inquiry, Myntha Anthym

Electronic Theses and Dissertations

This dissertation is an autoethnographic poetic illness narrative based on the author's year-long ordeal with unrelenting undertreated chronic pain. The project is grounded in the epistemological tradition of Black Feminist Thought and presented in alignment with the emergent methodological paradigm of critical arts-based inquiry. The purpose of the project is for the author to develop and articulate a radical reflexive praxis within the paradigm of critical arts-based inquiry while demonstrating the value of lived experience as a source of knowledge and poetry as a method of inquiry in revealing subjugated truths about the experiences of marginalized people. The dissertation lives …

Hidden In White(Ness)? Using Racial Logics To Interrogate The Instructional Arc Of A Crisis Intervention Team Training, Tara N. Meister

Electronic Theses and Dissertations

Some scholars argue that communities of color have been historically considered criminal by law enforcement (Fanon, 1963/2004; Gordon, 1996; Sharpley-Whiting, 1999), and Parenti (2003) and Kendi (2016) traced the history of modern policing to slave patrols. Wynter (2003) illuminated the racial logics undergirding our society - including policing - to the overlay of monotheism and its fixity with racial constructions of human as historically rooted in slavery and colonization. Thus, policing, too, carries a racialized dimension (Gamal, 2016) that creates or amplifies trauma and mental illness (Westcott, 2015). To address mental health, an undergirding feature of use of force and …

Effects Of Anthropogenic Noise On Mating Behavior And Fitness, Gabrielle A. Gurule-Small

Electronic Theses and Dissertations

When environments change rapidly, adaptive phenotypic plasticity can ameliorate negative effects of environmental change on survival and reproduction. Recent evidence, however, suggests that plastic responses to human induced environmental change are often maladaptive or insufficient to overcome novel selection pressures. Anthropogenic noise is a ubiquitous and expanding disturbance with demonstrated effects on fitness-related traits of animals like stress responses, foraging, vigilance, and pairing success. Elucidating the lifetime fitness effects of noise has been challenging because long-lived vertebrate systems are typically studied in this context. In both chapters described herein, I reared field crickets, Teleogryllus oceanicus, in masking traffic noise, …

Las Hijas De Violencia: Performance, The Street, And Online Discourse, Madison M. Snider

Electronic Theses and Dissertations

This paper explores street harassment as a contentious practice in the rhetorical spaces of the street and social media posting through a case study of the performance group Las Hijas de Violencia. Through anarchistic direct action resistance tactics, the group confronted harassers in the streets of Mexico City and their recordings launched global media interest which led to viral online sharing. Widespread sharing of their performance led to the creation of public discursive space, through comments sections, which was utilized to measure attitudes toward street harassment and feminist direct action protest. Contextualized in a growing call for an end to …

The Impact Of Sudden Gains And Deteriorations On The Psychotherapy Process, Joanna Mary Drinane

Electronic Theses and Dissertations

Within the field of psychotherapy research, there has been significant evidence to suggest that people change and improve because of treatment (Lambert & Ogles, 2004). One common phenomenon that has been observed when looking more closely at outcome trajectories has been termed sudden gains/deteriorations. These are defined as sudden changes in outcome (either positive or negative) of 25% or more from the pre-change level of symptoms that are in turn sustained over time (Tang & DeRubeis, 1999). Although there are data regarding how people who experience sudden gains end up after treatment, no studies have examined the impact that sudden …

Developing An Affect-Aware Rear-Projected Robotic Agent, Ali Mollahosseini

Electronic Theses and Dissertations

Social (or Sociable) robots are designed to interact with people in a natural and interpersonal manner. They are becoming an integrated part of our daily lives and have achieved positive outcomes in several applications such as education, health care, quality of life, entertainment, etc. Despite significant progress towards the development of realistic social robotic agents, a number of problems remain to be solved. First, current social robots either lack enough ability to have deep social interaction with human, or they are very expensive to build and maintain. Second, current social robots have yet to reach the full emotional and social …

The Political Economy Of Sandinismo 2.0: Environmental And Social Implications Of Paradoxical Economic Ideologies In Post-Revolutionary Nicaragua, Sarah Mccall Harris

Electronic Theses and Dissertations

This research investigates the political economy of Nicaragua's development, with specific emphasis on Venezuela and China's influence, energy policy, and environmental and social justice related to the Nicaragua canal. The first section focuses on the political economy of the current Ortega administration in Nicaragua, as part of the return of left-leaning leadership in Latin America since the early 2000s. This study examines the Ortega administration's selective interpretation of the concept of imperialism and its effect on the environment as it pertains to US interests, Venezuelan oil financing and socialist rhetoric, and China's control over a large piece of Nicaraguan territory …

A Shifting Island Landscape: Changes In Land Use And Daily Life In The 19th And 20th Century Village Of Inishark, Co. Galway, Ireland, Lauren Marie Couey

Electronic Theses and Dissertations

This thesis investigates changes to village spatial arrangement and land use patterns in the nineteenth and twentieth century village of Inishark, Co. Galway, Ireland. To understand how spatial changes within the historic village were shaped by interactions between villagers and outside groups, including landlords and government agencies, a landscape approach was utilized. An examination of historic maps, valuation documents, and Irish Census documents, combined with ground-penetrating radar (GPR) survey and archaeological excavation, were used to understand how historical pressures impacted island life. Inishark's geographic isolation creates a unique case study to understand the impact of historical pressures on rural Irish …

Examining The Role Of Liaison Librarians As Research Collaboration Partners: A Mixed-Methods Multiple-Case Study, Kawanna Michelle Bright

Electronic Theses and Dissertations

This sequential, mixed-methods study explored the professional relationship-building experiences of academic liaison librarians and university professors with a focus on research collaborations. A survey was administered and Chi-square and Spearman's rho analyses conducted on 2,650 responses to identify associations between organizational and individual factors and liaisons' work, perceptions of relationship-building experiences, and confidence in supporting faculty research. Following the survey, seven liaison-faculty pairs were identified and interviewed, and case study analysis utilized to explore specific liaison-faculty research collaboration relationships.

The study explored factors associated with liaisons' work, perceptions of faculty relationship-building, and confidence in supporting faculty research. The most salient …

Weathering Climate Change: Provisions For Climate Change Resiliency In Transboundary River Treaties, Emily Joan Zmak

Electronic Theses and Dissertations

Climate change will be most apparent in alterations to the hydrologic system - shifts in movement, variations in extremes - thereby defining many resource disputes in the coming decades. Water is a boundaryless resource; as its hydrologic patterns shift within and without borders, so too will preexisting agreements on its use and allocation. The question for transboundary water agreements is: how can agreements both satisfy parties' needs and account for future uncertainties of climate-induced changes to their basins' hydrologic systems?

From examining literature and water agreements, this thesis develops a list of provisions identified as foundational to resiliency in transboundary …

Life Partner Perceptions Of The Emotional Impact Of Stuttering, Athanasia Svenning

Electronic Theses and Dissertations

The aim of the present study is to investigate the extent to which life partners understand the emotional impact stuttering has on their loved one who stutters. This was accomplished by administering the Speech Situation Checklist - Emotional Reaction (SSC-ER), a subtest of the Behavior Assessment Battery (BAB; Vanryckeghem & Brutten, 2018) via Qualtrics, an online survey software, to the participants who stutter and a modified version of the SSC-ER to their life partner. No significant differences and a positive correlation were observed between groups (people who stutter (PWS) and their life partner (LP) as it relates to total score …

Improving The Detection Limit Of Tau Aggregates For Use With Biological Samples, Emily Rickman Hager

Electronic Theses and Dissertations

The protein Tau is found in neurofibrillary tangles in Alzheimer's disease and over 20 other neurodegenerative diseases. An assay has been developed to detect minute amounts of fibrils from human brain tissue. This assay subjects brain tissue extract and recombinant Tau to several rounds of sonication and incubation. Incubation allows recombinant Tau to add itself to the ends of the existing fibrils in brain tissue extract. Sonication breaks the existing fibrils in the brain tissue extract offering more ends for Tau to add onto. Cycles of sonication and incubation have been shown to allow for amplification of Tau fibrils from …

A Descriptive Policy Analysis Of State-Level Universal Preschool Adoption, Holly Higgins Wilcher

Electronic Theses and Dissertations

Presently, the United States does not have a publicly funded, comprehensive, universal ECE system. The fragmented and piecemeal approach to providing ECE creates social injustice and inequity for many young children (Kagan & Roth, 2017; Kagan, 2009). With the absence of comprehensive and streamlined federal ECE policy, several states have attempted to at least provide universal preschool to all four-year-old children. For states that aim to adopt universal preschool, it is critical to understand the factors, political conditions, and policy environments conducive to creating preschool policy change. Although many states would like to provide universal preschool, very few have been …

Photochemistry Of Polycyclic Aromatic Hydrocarbons With Environmentally Relevant Metals, John P. Haynes

Electronic Theses and Dissertations

The details of the work presented in this dissertation focus on simulated reactions in the atmosphere and water systems between persistent aromatic compounds and varying species of metals with an emphasis on iron. Bulk water suspensions of a standard soil and polycyclic aromatic hydrocarbons (PAH) were analyzed for soluble iron by inductively-coupled plasma mass spectroscopy (ICP-MS) following a 16 hour reaction period using simulated sunlight. Significant increases in soluble iron were only seen with 2-3 ring linear PAH and carboxylic acids.

A two-stage study was conducted to investigate the potential for and possible mechanisms involving the photo-oxidation of PAH into …

The Power Of Resurrection: Early Christian Resistance Through The Rise Of Disciplinary Power, Patrick G. Stefan

Electronic Theses and Dissertations

This dissertation is an analysis of the spread of Christianity in the first three centuries and the commensurate activation and development of what Michel Foucault calls disciplinary mechanisms of power. It sets out to explore two questions, first, what were the theoretical conditions that led to Christianity's rapid expansion? And second, what were the historical precursors to the mechanisms of disciplinary power? It then seeks to put these two questions together to propose that early Christianity was successful in overtaking the Roman Imperial government because it activated underlying disciplinary mechanisms of power in a world governed and controlled by sovereign …