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Design, Synthesis, And Evaluation Of Gunw-3 As A Brain Targeting Agent, Asim Najmi
Design, Synthesis, And Evaluation Of Gunw-3 As A Brain Targeting Agent, Asim Najmi
Electronic Theses and Dissertations
The blood brain barrier (BBB) is a barrier in the brain that separates the peripheral blood circulation system from the central nerve system (CNS). The barrier effectively protects the brain from xenobiotics. The BBB serves as a physical barrier through the tight junction of endothelial cells that were found to be 50-100 times tighter than that of normal endothelial cells. Different drug efflux pumps such as P-glycoproteins and multidrug-resistance proteins are found to be overdistributed on the BBB. These drug efflux pumps help pump xenobiotics out if they enter the cells and serv as an additional mechanism to prevent xenobiotics …
Differences In Running Mechanics And Tibial Plateau Dimensions Between Overweight/Obese And Healthy Weight Children, Claire Sylvestre
Differences In Running Mechanics And Tibial Plateau Dimensions Between Overweight/Obese And Healthy Weight Children, Claire Sylvestre
Electronic Theses and Dissertations
INTRODUCTION: Overweight and obese (OW/OB) children display increased knee joint loading during running, which may lead to excessive frontal plane motion and moments at the knee joints. The relationship between tibial plateau dimensions and knee vertical loading may explain the loading related injuries OW/OB children experience.
PURPOSE: Compare knee mechanics during running and tibial plateau dimensions between healthy weight (HW) and OW/OB children.
METHODS: Ten HW children and ten OW/OB children aged 9-12 participated in the study. Kinematic and kinetic data were captured as participants ran across a force platform at 3.5m/s. Tibial plateau area and density were collected by …
Characterizing Spatiotemporal Patterns Of White Mold In Soybean Across South Dakota Using Remote Sensing, Confiance L. Mfuka
Characterizing Spatiotemporal Patterns Of White Mold In Soybean Across South Dakota Using Remote Sensing, Confiance L. Mfuka
Electronic Theses and Dissertations
Soybean is among the most important crops, cultivated primarily for beans, which are used for food, feed, and biofuel. According to FAO, the United States was the biggest soybeans producer in 2016. The main soybean producing regions in the United States are the Corn Belt and the lower Mississippi Valley. Despite its importance, soybean production is reduced by several diseases, among which Sclerotinia stem rot, also known as white mold, a fungal disease that is caused by the fungus Sclerotinia sclerotiorum is among the top 10 soybean diseases. The disease may attack several plants and considerably reduce yield. According to …
Effects Of Increasing Dietary Levels Of Carinata Meal On Feeding Behavior, Performance And Carcass Characteristics Of Beef Growing Steers, Alejandro C. Casella
Effects Of Increasing Dietary Levels Of Carinata Meal On Feeding Behavior, Performance And Carcass Characteristics Of Beef Growing Steers, Alejandro C. Casella
Electronic Theses and Dissertations
The objectives of the present study are to evaluate feeding behavior, animal performance and carcass characteristics of beef growing steers fed increasing amounts of carinata meal (CM). Due to the high protein content of the CM after the oil extraction for biofuel there is an opportunity to use it as a protein supplementation in beef cattle. Twenty-four steers blocked by weight were assigned to four corn-based diets (n = 6 animals per treatment). In the three treatment diets, carinata meal replaced high-moisture corn at 5, 10, or 15%. The diets were fed using the Insentec RIC system for 138 days. …
Nutritional Transporter Mediated Drug Delivery For Cancer, Siddharth S. Kesharwani
Nutritional Transporter Mediated Drug Delivery For Cancer, Siddharth S. Kesharwani
Electronic Theses and Dissertations
Recent advancements in nanotechnology have unfolded novel opportunities in medicine, especially in targeted therapeutics and imaging for cancer. However, the majority of the existing nanotechnologies for cancer suffer from shortcomings such as (i) rapid elimination from the systemic circulation before reaching the cancer tissue. (ii) poor tumor accumulation, targeting, and penetration due to inadequate vasculature and extensive extracellular matrix in the tumor. Thus, overcoming these two limitations of nanotechnology is of considerable interests for cancer researchers. In this dissertation, we demonstrate the feasibility of glucose-modified nanoparticles (GLU-NPs) as an efficient cancer targeted-delivery system for enhancing the systemic circulation time and …
Alternative Treatment Options For Controlling Anthelmintic-Resistant Haemonchus Contortus Populations In South Dakota Sheep Herds, Adam Sarah
Electronic Theses and Dissertations
Haemonchus contortus is a common economically important gastrointestinal nematode that obliges the survival and productivity of small ruminants, especially sheep and goats. Anthelmintic resistance is a primary challenge in ruminant health management programs in preventing and controlling the H. contortus populations; therefore, there is a great necessity in finding and developing natural plant products for use as alternatives to commercial anthelmintics for controlling H. contortus in pastured sheep and goats. This dissertation has three major aims conducted in three separate studies: the first in vivo one was to evaluate the extended effect of a springtime, combined-treatment with 3 anthelmintics having …
Application Of Analytical Techniques In Food Product Development, Sonali R. Pandey
Application Of Analytical Techniques In Food Product Development, Sonali R. Pandey
Electronic Theses and Dissertations
Products are analyzed in major sectors of food industry to meet regulatory standards, food safety, quality control, and research and development. Analytical and extraction techniques have been applied for simultaneous investigation of multiple product characteristics. Food analysis faces critical challenges due to the complex composition of food, leading to matrix effects that result in loss of accuracy and reliability. The analytical techniques require an efficient sample preparation to avoid or minimize matrix effects. Solid-phase extraction has been widely used to address this issue. In this dissertation, the aim is to apply analytical techniques in food product development. To accomplish this, …
Performance Differences Between Two Groups Of Commercial Pigs Following Experimental Infection With Prrs Virus 1-7-4, Erin Little
Performance Differences Between Two Groups Of Commercial Pigs Following Experimental Infection With Prrs Virus 1-7-4, Erin Little
Electronic Theses and Dissertations
Porcine reproductive and respiratory syndrome virus (PRRSV) is the costliest swine disease in North America. Vaccines and management alone have not been effective in controlling this disease. Genetic selection for resilience may be a complimentary approach for controlling PRRSV. The objective of this study was to estimate performance differences between two groups of pigs from the same commercial line following infection with PRRSV 1-7-4: 1) pigs sired by boars selected based on a standard index (TN-S), which emphasized feed efficiency and carcass quality; and 2) pigs sired by boars selected based on an experimental index (TN-E), which emphasized feed intake, …
Winter Snow Depth In Arctic Alaska Results In Complex Changes In Caribou Forage Quality, Jessica C. Richert
Winter Snow Depth In Arctic Alaska Results In Complex Changes In Caribou Forage Quality, Jessica C. Richert
Electronic Theses and Dissertations
Caribou (Rangifer tarandus) rely on the short growing season for much of their annual nutrition, making them susceptible to even small changes in forage quantity and quality. Body condition in the summer and fall is linked to winter survival rates and fecundity in cows, critical factors in the robustness of caribou populations. Due to a warmer, wetter climate, snowfall is predicted to increase over Alaska’s North Slope in the next several decades. Deeper snow results in higher soil temperatures, allowing microbial mineralization of nitrogen to continue throughout the winter and increasing the availability of nitrogen for plants in spring and …
Rumen Microbial Culture Library And In Vitro Analysis Of Selected Bacterial Species On Colonization Resistance Against Bovine Enteric Pathogens, Maria Antony
Electronic Theses and Dissertations
The anaerobic habitat of the four chambers in ruminant’s foregut plays a vital role in the fermentation of the food by the active involvement of the residing microbial community. The cultivability and the potential role of rumen bacteria in the field of livestock production, host health and immunity are important to study. The developed anaerobic culturing techniques enable us to culture and screen different rumen bacteria to study the anti-pathogenic effects. Whole genome sequencing and analysis help us to understand the genome level characteristics of the rumen bacterial species individually. Since the majority of the rumen biosphere is still not …
Finite Mixture Of Regression Models For Complex Survey Data, Abdelbaset Abdalla
Finite Mixture Of Regression Models For Complex Survey Data, Abdelbaset Abdalla
Electronic Theses and Dissertations
Over time, survey data has become an essential source of information for modern society. However, to be effective, the structures of survey data require sampling designs that are more complex than simple random sampling. The complex sampling data collected from enormous national surveys via these complex designs ideally include sample weights that allow analysis to take account of complicated population structures. When the target of inference is the parameters of a regression model, it is crucial to know whether these weights should be incorporated into the sampling weight when fitting the model to the survey data. The finite mixture models …
How Are Interannual Variations Of Land Surface Phenology In The Highland Pastures Of Kyrgyzstan Modulated By Terrain, Snow Cover Seasonality, And Climate Oscillations? An Investigation Using Multi-Source Remote Sensing Data, Monika Anna Tomaszewska
How Are Interannual Variations Of Land Surface Phenology In The Highland Pastures Of Kyrgyzstan Modulated By Terrain, Snow Cover Seasonality, And Climate Oscillations? An Investigation Using Multi-Source Remote Sensing Data, Monika Anna Tomaszewska
Electronic Theses and Dissertations
In the semiarid, continental climates of montane Central Asia, with its constant moisture deficit and low relative humidity, agropastoralism constitutes the foundation of the rural economy. In Kyrgyzstan, an impoverished, landlocked republic in Central Asia, herders of the highlands practice vertical transhumance—the annual movement of livestock to higher elevation pastures to take advantage of seasonally available forage resources. Dependency on pasture resource availability during the short mountain growing season makes herds and herders susceptible to changing weather and climate patterns. This dissertation focuses on using remote sensing observations over the highland pastures in Kyrgyzstan to address five interrelated topics: (i) …
Searching For A Sense Of Place: The Process Of How Adolescent Girls Overcome Suicidality, Tamara Keefner
Searching For A Sense Of Place: The Process Of How Adolescent Girls Overcome Suicidality, Tamara Keefner
Electronic Theses and Dissertations
Suicide and self-harming behaviors are significant public health problems among children and adolescents globally and in the United States. Despite significant advances in recent decades to understand, prevent, and treat childhood and adolescent self-harming and suicide, suicide rates remain high. Since the National Action Alliance for Suicide Prevention set a goal to reduce suicide deaths and attempts by 40% by 2020, there has been a paradigm shift in the study of suicide yielding significant advances in the understanding of suicide and other forms of self-inflicted injury. This dissertation highlights some of the new developments in the study of suicide. First, …
Sunflower Pollinators In South Dakota: An Evaluation Of Species Composition, Abundance And Influence On Yield, Mackenzie Mattern
Sunflower Pollinators In South Dakota: An Evaluation Of Species Composition, Abundance And Influence On Yield, Mackenzie Mattern
Electronic Theses and Dissertations
In 2017 and 2018, South Dakota was the largest producer of sunflowers, Helianthus annuus L. (Asterales: Asteraceae) in the US, grossing approximately $178 million per year. In South Dakota, both confection and oilseed sunflower cultivars are grown. Despite breeding efforts to increase sunflower's ability to self-pollinate there is evidence that pollinator visitation results in increased sunflower yields. In addition, there is evidence that sunflower pollen is beneficial for pathogen resistance in various bee species, suggesting the importance of a mutualistic relationship between pollinators and sunflowers. In some areas, observed increases in sunflower yield is attributed to the presence of Apis …
The Impacts Of Land Use And Land Cover Change On Water Quality In The Big Sioux River: 2007-2016, Dinesh Shrestha
The Impacts Of Land Use And Land Cover Change On Water Quality In The Big Sioux River: 2007-2016, Dinesh Shrestha
Electronic Theses and Dissertations
Between 2006 and 2012, conversion of 485,000 acres of grassland to cropland in eastern South Dakota was reported. In 2012, the Big Sioux River (BSR) running through most of eastern South Dakota was listed among the dirtiest rivers in the nation. This rating convinced state authorities to study trends of land cover changes in the BSR watershed and its association with BSR water quality with respect to increases in nitrate levels. This research i) quantifies spatial and temporal changes in the land cover types within the BSR watershed, and ii) identifies any correlation between these changes and changes in BSR …
The Role Of A Community Coach In Rural Food Councils In Six Midwestern States, Kaitlyn Tusha
The Role Of A Community Coach In Rural Food Councils In Six Midwestern States, Kaitlyn Tusha
Electronic Theses and Dissertations
Objective: To quantitatively assess perceived coaching confidence of a community coach working with food councils, and to qualitatively determine perceived barriers and facilitators associated with coaching rural food councils.
Design: Two phases were implemented using a mixed methods study design with quantitative (scorecard) and qualitative (key informant interviews) methodologies.
Setting: Six rural, Midwestern states implementing Voices for Food.
Participants: Voices for Food community coaches (n=9) who coached rural food council(s).
Intervention: A component of the broader Voices for Food intervention.
Analysis: Quantitative scorecard data were analyzed with STATA by running paired ttests. Qualitative key information interview data were analyzed with …
The Relationship Between Campus Wellness Center Usage And Symptoms Of Depression In College Freshmen, Allison Leonard
The Relationship Between Campus Wellness Center Usage And Symptoms Of Depression In College Freshmen, Allison Leonard
Electronic Theses and Dissertations
There is limited research done on the relationship between the program utilization at a campus wellness facility and the symptoms of depression in college freshmen. College students have been found to have a higher prevalence of depressive symptoms than the general population, possibly due to the stressors college life can add. Studies have been done on the effects of physical activity as an intervention for depression as well as on the benefits of campus wellness facilities; however, there have been few studies that look at both campus recreation and depression. The author’s purpose for this study was to see if …
Evaluation Of Effects Of Methods Used For Forage Analysis And Dietary Inclusion Of Buffer On Fiber Digestibility And Rumen Fermentation In Diets High In Distillers Grains, Lydia Kehinde Olagunju
Evaluation Of Effects Of Methods Used For Forage Analysis And Dietary Inclusion Of Buffer On Fiber Digestibility And Rumen Fermentation In Diets High In Distillers Grains, Lydia Kehinde Olagunju
Electronic Theses and Dissertations
Forage quality is an important factor affecting intake and utilization of forage, thus making it imperative to evaluate the methods used to determine the nutritive values of forage in order to predict animal performance. Additionally, fibrous feeds for ruminants are less subject to competitive demand. The plant cell wall is the largest hindrance to complete digestion of feeds, particularly forages and by-products and to the utilization of the nutrients and energy they contain, necessitating effective strategies for increasing the rate and efficiency of utilization of forage fiber and the energy therein. It is critically important to increase fiber digestion for …
The Impact Of Alcohol Consumption On Academic Success And Athletic Identity In Collegiate Student-Athletes, Zoe E. Arnold
The Impact Of Alcohol Consumption On Academic Success And Athletic Identity In Collegiate Student-Athletes, Zoe E. Arnold
Electronic Theses and Dissertations
Upon entering college in the United States, students are exposed to alcohol and, relatedly, the potentially dangerous experiences and effects that come with consuming alcohol. This is especially true for collegiate student-athletes, who have been found to have the highest consumption rate among student groups on campus. The purpose of the study was to understand the relationship between how student-athletes at a focus university, a Division I member of the National Collegiate Athletic Association, experience alcohol consumption, how their consumption affects their academic grade point average (GPA), and how athletic identity plays a role in their experiences. While the research …
Evaluation Of Flax Oil Supplementation On Performance Of Growing Dairy Heifer Calves And Lactating Cows, Chelsea Rose Schossow
Evaluation Of Flax Oil Supplementation On Performance Of Growing Dairy Heifer Calves And Lactating Cows, Chelsea Rose Schossow
Electronic Theses and Dissertations
Utilization of flax oil is new to the livestock industry, and limited research has been done to see the benefits of feeding the highly unsaturated oil to both dairy calves and lactating cows. Two studies were conducted to evaluate the potential benefits of flax oil as a lipid supplement. The first study compared the supplementation of two plant based oils to growing dairy calves. Thirty-six female Holstein calves in individual hutches were used in a 12-wk randomized complete block design study. Treatments were: 1) control (CON) with no oil, 2) 80 g/d of flax oil (FLAX), and 3) and 80 …
Escherichia Coli Removal From Stormwater Using Steel Chips Filter, Peng Dai
Escherichia Coli Removal From Stormwater Using Steel Chips Filter, Peng Dai
Electronic Theses and Dissertations
Media filtration has received increasing attention as an effective technology that can facilitate the removal of particles and dissolved pollutions in the stormwater. However, most traditional media filtration systems are generally ineffective in removing bacteria, causing pollution of groundwater and receiving surface water. In this study, recycled steel chips were evaluated as low-cost filter materials for bacterial removal from stormwater. Laboratory column experiments were conducted to evaluate the impact of steel chips particle size, flow rate, initial E.coli concentration, pH, natural organic matter (NOM), steady and intermittent flow on E.coli removal. The results showed that E.coli removal decreased from 99.4% …
Development Of A Novel Nanotechnology-Based Vaccine Adjuvant And Delivery System For Systemic And Mucosal Immunity, Mohammed Ali Bakkari
Development Of A Novel Nanotechnology-Based Vaccine Adjuvant And Delivery System For Systemic And Mucosal Immunity, Mohammed Ali Bakkari
Electronic Theses and Dissertations
Many serious infections for which there are no existing vaccines, enter by a mucosal route such as HIV, influenza, and tuberculosis, etc. Therefore, designing safe and effective mucosal vaccines that elicit robust immune response at mucosal sites is still a major challenge without a safe mucosal adjuvant. Previously, our laboratory had discovered inulin acetate as a novel toll-like-receptor-4 agonist (adjuvant). The study in this dissertation explored the application of nanoparticles prepared with inulin acetate (InAc-NPs) as a vaccine adjuvant and delivery system for enhancing mucosal immunity. The rationale behind selecting InAc-NPs is their proven ability to activate strong systemic immunity …
Cropping Sequence Affects Subsequent Soybean Yield, Soil Microbiome And Soil Health, Izzet Bulbul
Cropping Sequence Affects Subsequent Soybean Yield, Soil Microbiome And Soil Health, Izzet Bulbul
Electronic Theses and Dissertations
Rotation is an important cultural practice that farmers use to manage crop growth and diseases. Diversified crop rotations directly affect plant residue inputs that may enrich specific groups of microbes that form beneficial associations with the following crop. At two field sites, yield differences were observed in soybeans planted after the following four long-term (14 year) crop sequences: continuous corn (CC), corn (Zea mays)/corn/soybean (Glycine max) (CCS), corn/soybean/corn (CSC), soybean/corn/soybean (SCS). Soybean yields were in decreasing order, CC>CCS>CSC>SCS, and the yield differences could not be explained by soil chemical and physical properties previously …
A Comparison Between The Efficacy Of Traditional Periodization, Undulating Periodization, And Plyometric Training And Their Lasting Effects On Performance Outcomes In Youth Athletes. A Systematic Review And Meta-Analysis, Andre Mcintyre
Electronic Theses and Dissertations
Recreational and competitive youth (≤ 16 years old) sport participation over the years has increased in recent years. As a result of increased sport participation an emphasis on sport performance training and more particularly resistance training along with plyometric training have been on the rise. Resistance training and plyometric training can improve sports performance, rehabilitate injuries, prevent injuries, and enhance long-term health in adolescent athletes. Resistance training can be periodized numerous different ways, but the most popular training methods are traditional periodization, undulating periodization, and plyometric training. This systematic review and meta-analysis examined studies that compared traditional periodization, undulating periodization, …
Relationship Of Weight-Related Eating Behaviors And Weight-Loss Of Participants In A Proprietary Weight-Loss Program, Megan Tschakert
Relationship Of Weight-Related Eating Behaviors And Weight-Loss Of Participants In A Proprietary Weight-Loss Program, Megan Tschakert
Electronic Theses and Dissertations
The aim of this study is to evaluate weight-related eating behaviors of participants with clinically significant weight loss (CSWL) in a proprietary weight loss program. A crosssectional sample of participants (n=1,454) enrolled in a proprietary weight-loss program that includes meal replacements and health coaching were queried for weight-related eating behaviors (using Weight Related Eating Questionnaire) of routine restraint (RR), compensatory restraint (CR), susceptibility to external cues (SEC), and emotional eating (EE) in relation to CSWL (defined as having achieved a weight loss greater than 10% of starting weight). Participants were dichotomized into those with CSWL (n=973) and with no CSWL …
Maximizing Ecosystem Services Provided To The New Oil Crop Brassica Carinata Through Landscape And Arthropod Diversity, Shane Stiles
Maximizing Ecosystem Services Provided To The New Oil Crop Brassica Carinata Through Landscape And Arthropod Diversity, Shane Stiles
Electronic Theses and Dissertations
Prairies, once spanning the Upper Midwest, have now largely been replaced by agriculture. The lack of resources available to pollinators in agricultural fields and the practices employed by farmers to maximize yield has led to a decline in insect and pollinator diversity. There is a need to better understand how ecosystem services provided by a diverse insect community scale to current farming practices as they relate to crop yield. We sought to explain how landscape heterogeneity relates to insect and pollinator diversity, as well as how insect diversity relates to crop yield across common farming practices. To evaluate how farming …
Pilot Scale Evaluation Of E. Coli Filtration Removal From Stormwater Using Recycled Steel, Jason Neville
Pilot Scale Evaluation Of E. Coli Filtration Removal From Stormwater Using Recycled Steel, Jason Neville
Electronic Theses and Dissertations
Microbial pathogens are considered one of the most important pollutants in regards to surface waters such as coastal waters, rivers and urban estuaries. Escherichia Coli (E. coli) is a bacterial microorganism found in the guts of humans and some animals that if ingested can cause diarrhea, severe stomach cramps, and vomiting. E. coli carried by stormwater runoff can deteriorate water quality of receiving bodies of water. It is necessary to develop technologies to remove E. coli from stormwater runoff to protect surface waters and public health. The use of steel byproducts as an adsorption technology is an emerging stormwater treatment …
Using Maximum Power As A Variable For 1rm Prediction In The Squat And Bench Press, Sean O'Connor
Using Maximum Power As A Variable For 1rm Prediction In The Squat And Bench Press, Sean O'Connor
Electronic Theses and Dissertations
Many Strength and Conditioning (S&C) coaches utilize a one-rep max (1RM) exercise test to gauge the maximal strength of athletes, and then prescribe resistance training programs based on a relative percentage of 1RM to obtain strength or power adaptations. However, many S&C coaches have raised questions regarding the safety and necessity of a 1RM test. Attempts to mitigate the weaknesses of 1RM testing have led to other methods of testing including repetition max testing (3RM, 5RM, 10RM, etc.) as well as load/velocity profiling. The main purpose of this study is to determine if 1RM can be accurately estimated from maximal …
African American Student-Athletes: Factors Influencing Choice Of Graduate School, Tanner Feterl
African American Student-Athletes: Factors Influencing Choice Of Graduate School, Tanner Feterl
Electronic Theses and Dissertations
Although support systems are in place for student-athletes, African Americans remain underrepresented in careers requiring a graduate education, including intercollegiate athletic departments (Okahana, Feaster, & Allum, 2016). The purpose of this qualitative, phenomenological study was to explore the factors influencing an NCAA Mid-major, Division I African American student-athletes’ choice of pursuing graduate school. Researchers identified themes utilizing Critical Race Theory (CRT) and Student Involvement Theory frameworks to explain the influencing factors. The participants consisted of nine African American sophomore, junior, and senior student-athletes who participated in different sports and were chosen using purpose sampling. Each participant took part in an …
Our Stigmatized American Heroes: Examining How Veterans With Ptsd Communicatively Manage Stigma, Rikki A. Roscoe
Our Stigmatized American Heroes: Examining How Veterans With Ptsd Communicatively Manage Stigma, Rikki A. Roscoe
Electronic Theses and Dissertations
Mental health conditions are arguably the most prominent disabling medical condition that military service members endure. Veterans with combat-related PTSD often refrain from seeking mental health treatment due to the stigma attached. Concealing PTSD or attempting to cope without professional help can lead to extreme and lifethreatening consequences including depression, substance abuse, and suicide. Attaining a better understanding of stigma management strategies is important because it has the ability to help veterans better manage stigma in the future. Thus, the current study uses stigma management communication theory (Meisenbach, 2010) to uncover the ways in which veterans with PTSD communicatively manage …