Digital Commons Network^™

Genetic Diversity Of White-Tailed Deer Populations In Southwestern Pennsylvania And The Development Of A Forensics Panel, Melanie Quain

Electronic Theses and Dissertations

During the 20^thcentury, white-tailed deer (Odocoileus virginianus) became scarce, prompting conservation efforts by hunters and wildlife managers with the goal to recover this species. Various strategies were implemented including reintroductions from areas that still had large deer populations, developing bag limits, seasonal restrictions, and habitat management. These efforts were highly successful across the United States.

Today, white-tailed deer are one of the most abundant and widely-distributed large-bodied mammals in North America. However, there are several important management concerns. In numerous states, including Pennsylvania, CWD negatively impacts deer populations and has become a major health concern. When …

Design And Synthesis Of Pyrimidine Based Heterocycles As Potential Anti-Cancer Agents With Combination Chemotherapeutic Potential Or Targeted One Carbon Metabolism Inhibition And Anti-Opportunistic Agents, Arpit Doshi

Electronic Theses and Dissertations

This dissertation describes the design, synthesis and biological evaluation of monocyclic, bicyclic and tricyclic pyrimidine-based heterocycles as a) single agents with combination chemotherapy potential having dual antiangiogenic effects and cytotoxic effects or b) one-carbon metabolism inhibitors for targeted tumor therapy; or c) selective Pneumocystis jirovecii (pj) dihydrofolate reductase (pjDHFR) inhibitors for pneumocystis pneumonia (PCP) infection.

The work in this dissertation is centered on identifying structural features that are necessary for inhibition of tubulin polymerization or thymidylate synthase as well as for inhibition of one or more of the receptor tyrosine kinases (RTKs)- vascular endothelial growth factor receptor-2 (VEGFR2), epidermal growth …

Mentor As Scaffold: A Mixed-Methods Exploration Of Feminist-Informed Mentoring In The Undergraduate Setting, Elizabeth Bennett

Electronic Theses and Dissertations

There has been little consensus around the definition or meaning of mentoring as a phenomenon. As highlighted first by Jacobi (1991) and more recently by Crisp and Cruz (2009), the relatively small mentoring literature is plagued by a poor understanding of mentoring itself. Additionally, there are few guiding recommendations for the development of formal mentoring programs, particularly those informed by feminist pedagogy and theory, at the undergraduate level. To begin to address these gaps in the mentoring literature, I conducted a mixed-methods study with a convergent parallel design (Creswell & Clark, 2007) and qualitative emphasis. Eight participants completed individual, semi-structured …

Carer Information Needs Following A Family Member's Right Hemisphere Stroke, Christyn Davidson

Electronic Theses and Dissertations

Background: Previous studies have explored information needs for carers of persons with aphasia; however, there is minimal research on information needs of carers with right hemisphere disorder (RHD). RHD describes cognitive and communication impairments a person experiences following a right hemisphere stroke or brain injury. Carers have an important role in rehabilitation and the long-term quality of life of a person with RHD. This study explores the information needs for carers following a family member’s right hemisphere stroke throughout different periods of recovery.

Methods/Procedures: Participants completed online surveys and a semi-structured phone interview. Analysis of the interviews revealed four major …

Does Emotional Intelligence Moderate The Effect Of Field Work Experience On Counseling Students' Group Counseling Self-Efficacy, John Lewis

Electronic Theses and Dissertations

Counselor educators and supervisors need a comprehensive understanding of counseling students group counseling development with the aim of assessing student learning outcomes and facilitating academic and supervisory interventions that support development. The purpose of this study was to investigate the relationship between emotional intelligence and group counseling self-efficacy and determine the feasibility of using emotional intelligence to predict changes in group counseling self-efficacy. Results indicated that although there was significant increase in group counselor self-efficacy after a semester of fieldwork experience, the results showed no significant relationship between emotional intelligence and group counselor self-efficacy. Practical implications and future directions for …

A Quantitative Study Of Drug Recrystallization In Drug-In-Adhesive Transdermal Patches Using Vibrational Spectroscopy, Yi Li

Electronic Theses and Dissertations

Drug-in-adhesive (DIA) transdermal patches are an important type of transdermal drug delivery system (TDDS). The drugs used in the DIA system are frequently present in metastable forms, such as amorphous solids or supercooled liquids. These drug states are thermodynamically unstable and tend to undergo recrystallization. Recrystallization of the active pharmaceutical ingredient can adversely affect the efficacy of transdermal products. This dissertation demonstrates a systematic approach to quantify the crystalline content of the API in DIA systems. This approach uses a novel method of preparing calibration standards and a spectroscopic method to reliably predict crystalline content in DIA patches. Spectroscopic tools, …

Impact Baseline Composite Score Differences Among Student Athletes, Kerry Schutte

Electronic Theses and Dissertations

The ImPACT aims to measure neurocognitive functioning in student athletes. Many schools administer preseason ImPACT assessments to determine athletes’ baseline functioning. Follow-up ImPACT assessments are administered to athletes who sustain concussions to compare their pre- and post-injury functioning. Normative data may be used in place of individualized baseline scores if athletes were not administered baseline assessments. At the inception of this study, normative datasets consisted of scores from typically developing athletes. However, research suggests athletes of varying gender and exceptionality statuses perform differently on baseline ImPACT assessments. In particular, differences were found among male and female athletes as well as …

Beyond A Reasonable Doubt: A Discourse Analysis Of Forensic And Psychological Truth In Child Narratives, Elizabeth Samson

Electronic Theses and Dissertations

This dissertation draws on a hermeneutically-informed modification of Potter and Wetherell’s (1987) discourse analysis methodology to explore how child memory and experience are conceptualized in two widely-used forensic psychology training manuals. Current research about child testimony tends to focus on how well children can factually recount their experiences, or on optimizing interviewer performance so as to obtain accurate accounts and minimize the risk of distorting children’s memories. Results of this discourse analysis include: 1) frequent advisement of evaluator caution, objectivity, and thoroughness, since evaluators are understood as responsible for preserving the accuracy of children’s memories during the evaluation process; and …

Humeral Retroversion, Range Of Motion, And Strength Adaptations In Tennis Players, Daniel Hannah

Electronic Theses and Dissertations

Purpose: This study aimed to develop an understanding of humeral retroversion (HRV) asymmetries in tennis players and its impact on physical and performance characteristics of the shoulder.Participants: Healthy tennis players were categorized into 3 groups: younger juniors (n=11, age=14.5±0.5 years), older juniors (n=12, age=17.1±0.9 years), and collegiate (n=16, age=19.6±1.2 years). Methods: HRV, internal rotation (IR), and external rotation (ER), total arc of motion (TAM), HRV-corrected IR (HRVcIR), and HRV-corrected ER (HRVcER) were measured and calculated bilaterally using a digital inclinometer and ultrasonography. Bilateral differences (Δ) were calculated (dominant minus nondominant) for HRV and ROM variables. Isometric ER:IR strength ratios …

Using An Extended Broken Symmetry Approximation To Characterize Structure And Spectroscopic Properties Of 2fe-2s Clusters, Ashlyn M. Koval

Electronic Theses and Dissertations

Iron-sulfur proteins perform a wide variety of biological functions that assist in mediating protein function via electron transfer reactions. The Rieske and mitoNEET iron-sulfur clusters have been shown to undergo proton coupled electron transfer facilitated by a histidine ligand. The protonation state of the histidine residue is key to understanding the mechanism of proton coupled electron transfer. This work reports a study of the 2Fe-2S ferredoxin, Rieske, and mitoNEET clusters using the extended broken symmetry approximation. Calculations were performed on the ferredoxin cluster to establish appropriate methodologies. Calculations were then performed for Rieske and mitoNEET clusters to suggest experiments capable …

Dual Inhibition Of The Pi3k/Akt And Mek5/Erk5 Pathways For The Treatment Of Breast Cancer, Thomas Douglas Wright

Electronic Theses and Dissertations

Breast cancer is a heterogeneous disease state with several challenging frontiers. In particular, aberrations in the Phosphoinositide-3-kinase (PI3K) and Mitogen Activated Protein Kinase (MAPK) pathways have been linked to increased breast cancer proliferation and survival. It has been proposed that these survival characteristics are enhanced through compensatory signaling and crosstalk mechanisms. New evidence suggests that MEK5/ERK5, a member of the MAPK family, is a crucial component in the proliferation and survival of several aggressive cancers. We hypothesize that inhibiting both PI3K/Akt and MEK5/ERK5 pathways will decrease cell viability while maintaining limited collateral toxicity. In this study, we examined the effects …

Kink In Flux: Bdsm Theory And Sexual Praxis, Celeste Pietrusza

Electronic Theses and Dissertations

The opening decades of the 21^st century have seen a veritable explosion of representations of bondage, discipline and sadomasochism (BDSM) and kink practices in mainstream media and American culture. Along with this, empirical researchers working in sexuality studies continue to show, contrary to the history of stigmatizing accounts in the history of clinical psychology, no evidence of increased pathology and, in some studies, better outcomes on measures of mental health.

Given the legacy of psychoanalysis in foregrounding considerations of sadomasochism and sexuality for the human psyche, it seems particularly well positioned to approach the complexities of dynamic fantasies involved …

Triple Functionalization Of Titanium Aluminum Vanadium For Orthopedic Implant Applications, Ashley Blystone

Electronic Theses and Dissertations

Orthopedic implant surgeries are on the rise in the United States, with well over a million surgeries performed annually. Common materials used for these applications include titanium and its alloy, titanium aluminum vanadium (Ti-6Al-4V). Ti-6Al-4V is chosen for this application due to its mechanical strength and corrosion resistance. However, Ti-6Al-4V does not support osseointegration and is susceptible to bacterial colonization. Therefore, these implants suffer from aseptic loosening and infection, necessitating removal and replacement. Revision surgery and treatment is financially burdensome and taxing on the patient. Current approaches focus on modifying the surface of Ti-6Al-4V through a variety of means to …

Reclaiming Embodiment: An Existential-Phenomenological Exploration Of Women’S Tattoos, Ashley Gill

Electronic Theses and Dissertations

This dissertation is a phenomenological research study about the lived experiences of women who elected to get tattoos in the last five years. Due to historical and present discourses on female embodiment and persistent stigmas and pathologies often associated with tattoos, I sought to generate meaningful knowledge about the lived experiences of women who have voluntarily chosen this form of body modification. I conducted phenomenological research interviews with nine participants about personal meanings, decision making processes, and lived experiences of embodiment (capturing existential themes of lived body, spatiality, relationality, and time) before and after tattooing. I applied thematic interpretation of …

The Role Of A Permeable Sand Column In Modifying Tidal Creek Geochemistry And Land-Derived Inputs To The Coastal Ocean, Nicholas Anthony Legut

Electronic Theses and Dissertations

The impairment of regional water quality in Long Bay is an episodic occurrence that has been documented for over a decade. According to one explanation, the occurrence of these events is hypothesized to be the combination of local, terrestrially derived inputs and water-column stratification in the nearshore zone. A portion of these inputs may discharge as surface run-off through estuaries ending in sandy transitional environments termed "swashes". An investigation into the fate of land-derived materials through swashes utilize a linear conservative mixing model to describe the non-conservative behavior of materials in the overlying water and pore-water. This model relies on …

Urban (Un)Planning And Social Vulnerability In The Context Of Rapid Urbanization And Data Constraints: A Quantitative Study Of Dar Es Salaam, Tanzania., Sheliza Bhanjee

Electronic Theses and Dissertations

This dissertation explores intersections between vulnerability and urban planning in Sub-Saharan Africa, where distinct forms of urbanization are occurring and where there are significant data constraints limiting local studies and urban assessments in the region. The three studies which make up this dissertation offer methodological and theoretical pathways toward examining and measuring the influence of urbanization and planning factors on vulnerability of urban populations in the region. The first study is a literature review and examines existing literature for vulnerability conceptualization in urban environments, the notion of ‘urban vulnerability’, and roles of urban planning and related factors in relation to …

Digital Political Information Consumption And Ambivalent Political Attitudes., Dane Ryan Warner

Electronic Theses and Dissertations

Understating how individuals form, reinforce, or change attitudes has a long history in political science research. This study seeks to contribute to the existing literature by bridging the gap between the ambivalence and digital political communications literature by examining the relationship between digital political information consumption and ambivalent political attitudes. Using the American National Election Studies 2016 Time Series Study, I examine the role of digital political information consumption as a moderator of value conflict and ambivalent political attitudes. The findings suggest that increased levels of information gather significantly reduce group ambivalence, candidate ambivalence, and value ambivalence.

Characterizing The Role Of Extracellular Matrix In Non-Small Cell Lung Carcinoma Metastasis Using A 3d Microenvironment Mimetic In-Vitro Culture System., Douglas John Owulaku Saforo

Electronic Theses and Dissertations

Lung cancer is the leading cause of cancer related death in the United States and worldwide. Five-year survival rates for non-small cell lung carcinoma patients have not improved in decades, and a majority of patients succumb to metastasis. Identification of therapeutic targets for metastatic disease is essential for the development of novel therapies. However, current 2-dimensional (2D) in vitro models are not reflective of the tumor microenvironment (TME) and are inadequate in identifying therapeutic targets. We adapted a 3-dimensional (3D) extracellular matrix (ECM) in vitro model to a hypoxic incubator to approximate physiological hypoxia of the TME in a microenvironment …

A Distinct Pattern Of Sterile Inflammation Induced By Zinc Oxide Nanowires., Ruqaih Salem Alghsham

Electronic Theses and Dissertations

In recent years, there has been an increasing interest in nanotechnology. Engineered nanomaterials (ENMs) become an increasingly important area in nanotechnology. Recent developments in ENMs have drawn commercial and research attention in many areas such as agriculture, medicine, and Industry. High-aspect ratio zinc oxide nanowires (ZnONWs) have become one of the most significant ENMs due to their remarkable physical properties which makes them useful in a wide-range of applications. However, questions have been raised about ZnONW safety uses and biological consequences. In this dissertation, we investigated the inflammatory potential of ZnONWs in mouse models. C57BL/6 mice were exposed to ZnONW …

Probability Of Conception After Fertility Counseling And The Association Of Sexually Transmitted Infections With Pregnancy In The Loussi Study., Lindsey Adelle Wood

Electronic Theses and Dissertations

This study interrogated predictors of pregnancy and the effect of a history of sexually transmitted infection (STI) on probability of conception among a cohort of women seeking fertility counseling (N=170), using multivariable logistic regression and Cox proportional hazards models. There were 76 (44.7%) total pregnancies. 32 (39.0%) were achieved spontaneously by women who never received ART (N=82). Among women who did receive ART (N=88), 35 (39.7%) were achieved by ART and 9 (10.2%) achieved spontaneously. Among the full cohort (N=170), obesity was a significant negative predictor of pregnancy while history of human papilloma virus was a significant negative predictor of …

Mapping Rural Literacy Sponsorship Networks : Literacy Infrastructures And Perceptions In Abbyville., Amy Mccleese Nichols

Electronic Theses and Dissertations

Recently, the academy has become aware that rural students are choosing to attend institutions of higher education less often than their urban counterparts. Rationalizing why this particular population remains underserved by institutions of higher learning is a new conversation for higher education. And yet, in literacy studies, the perceived urban/rural divide in terms of national politics sometimes seeps into conversations about the perceived “literacy” or culture of rural peoples. This polarization, unaccompanied by detailed portraits of rural community literacy sponsorship, means that rural areas do not benefit from the consistent attention paid to their urban counterparts in New Literacy Studies. …

Adaptive Physical Human-Robot Interaction (Phri) With A Robotic Nursing Assistant., Sumit Kumar Das

Electronic Theses and Dissertations

Recently, more and more robots are being investigated for future applications in health-care. For instance, in nursing assistance, seamless Human-Robot Interaction (HRI) is very important for sharing workspaces and workloads between medical staff, patients, and robots. In this thesis we introduce a novel robot - the Adaptive Robot Nursing Assistant (ARNA) and its underlying components. ARNA has been designed specifically to assist nurses with day-to-day tasks such as walking patients, pick-and-place item retrieval, and routine patient health monitoring. An adaptive HRI in nursing applications creates a positive user experience, increase nurse productivity and task completion rates, as reported by experimentation …

Opioid And Stimulant Use Among A Sample Of Corrections-Involved Drug Users : Seeking An Understanding Of High-Risk Drug Decisions Within A System Of Constraint., Kirsten Elin Smith

Electronic Theses and Dissertations

In the United States, high-risk drug use remains a significant social problem. Opioids and stimulants are two drug classes that have contributed to substantial recent increases in drug-related arrests, overdose, and mortality. Kentucky has been particularly devastated by high rates of opioid and stimulant use. Opioid and stimulant effects, while highly rewarding, can result in adverse consequences. Still, some people choose to use these drugs, and choose to continue using even after experiencing adverse consequences, such as incarceration. The aim of this study was to explore high-risk drug use among a sample of corrections-involved adults in Kentucky and to identify …

Functional Opponency In Working Memory Capacity Predicts Cognitive Flexibility In Problem Solving., Charles A. Van Stockum Jr.

Electronic Theses and Dissertations

Cognitive flexibility is a hallmark of individuals with higher working memory capacity (WMC). Yet, research demonstrates that higher WMC individuals are sometimes more likely to adopt rigid problem-solving approaches. The present research examines a novel account for these contradictory findings—that different WMC mechanisms interact in ways that both support and constrain cognitive flexibility. Across three studies, participants completed the water jug task—a problem-solving task requiring them to first establish and then break mental set using a complex strategy. Participants then completed measures targeting three WMC mechanisms: attention control, primary memory, and secondary memory. Study 1 demonstrated that primary memory and …

The Effect Of Spinal Cord Injury On Sexual Function., Casey J. Steadman

Electronic Theses and Dissertations

Spinal cord injury (SCI) causes severe neurological impairment with widespread motor, autonomic and sensory deficits, leading to a substantial quality of life impairment. The number of individuals with SCI increases by approximately 12,500 annually, and over 80% of individuals with SCI are males. SCI individuals rate sexual function as a top priority quality of life issue, and men with SCI likely suffer from sexual dysfunction, such as erectile and ejaculatory dysfunction, as well as infertility. Regardless of the high status of importance of sexual function, limited numbers of experimental studies in SCI animal models have focused on sexual function after …

Exploring Individual And Dyadic Associations Of Dispositional Mindfulness As An Ameliorative Factor Of Anxiety And Roommate Satisfaction Among Undergraduate Roommates., Kala Phillips

Electronic Theses and Dissertations

For many young adults, the college experience is stressful and the adjustment to college life can present many unique challenges. Up to one-half of undergraduates report anxiety, with prevalence rates that appear to be on the rise. Social transitions, such as living with a roommate, can also present challenges. The current study explored dispositional mindfulness, a capacity for attending to present-moment experiences, as a potential ameliorative factor of anxiety and roommate satisfaction. Dyadic associations of dispositional mindfulness were also explored among roommate dyads. Fifty undergraduate roommate dyads (N=100) provided self-report measures of demographics, dispositional mindfulness, anxiety, and three facets of …

Characterization Of A More Clinically Relevant Human Leukemia Xenograft Model To Examine Perturbation Of Met/Sam Metabolism As A Novel Therapeutic Paradigm For Mll-R Leukemia In Vivo., Aditya Barve

Electronic Theses and Dissertations

Acute myeloid leukemia (AML), is a heterogeneous clonal disorder characterized by an accumulation of malignant myeloid progenitors in the bone marrow (BM), hindering normal hematopoiesis. AML exhibits dramatic heterogeneity in terms of cytogenetics, morphology, and chemotherapeutic sensitivity. Therefore, the investigation of novel, efficacious AML therapeutics will require advanced preclinical in vivo model systems, capable of recapitulating patient specific disease heterogeneity, and induction chemotherapy outcomes. A major focus and eventual outcome of this work was the establishment and development of a more clinically relevant mouse xenograft model of patient AML, that efficiently harbors patient derived xenografts (PDXs), and unlike more prevalent …

Disordered Eating, Depression, And Cognitive Vulnerabilities In College Women., Kelsea Visalli

Electronic Theses and Dissertations

This study tests a path model of disordered eating and symptoms of depression derived from the Hopelessness Theory of Depression (Abramson, Metalsky, & Alloy, 1989). The model proposes that cognitive vulnerabilities to depression will be associated with disordered eating behaviors and symptoms of depression in college women. A sample of undergraduate women (n = 181) completed self-report measures assessing disordered eating symptoms and symptoms of depression. Findings revealed that one, but not all, cognitive vulnerability was associated with disordered eating behavior, and that disordered eating behaviors and symptoms of depression are bi-directionally associated. Implications and future research directions are discussed.

Predictors Of Empirically-Supported Interventions Following Structured Functional Assessment., Alton Nathaniel Verbist

Electronic Theses and Dissertations

Assessment is foundational to the process of evidence-based practice yet has received little research attention. Project SAFESPACE has recently initiated screening and assessment for all children entering out of home care in Kentucky with the goal of providing assessment-driven, evidence-based treatment. The Child and Adolescent Needs and Strengths (CANS) assessment—the instrument adopted in this service system—is designed to link the assessment process with the selection of appropriate interventions. Informed by naturalistic decision making, this dissertation sought to investigate the relationship between responses on the CANS assessment and the empirically supported interventions subsequently prescribed by the assessing clinician. Using secondary data …

Novel Bayesian Methodology In Multivariate Problems., Debamita Kundu

Electronic Theses and Dissertations

This dissertation involves developing novel Bayesian methodology for multivariate problems. In particular, it focuses on two contexts: shrinkage based variable selection in multivariate regression and simultaneous covariance estimation of multiple groups. Both these projects are centered around fully Bayesian inference schemes based on hierarchical modeling to capture context-specific features of the data and the development of computationally efficient estimation algorithm. Variable selection over a potentially large set of covariates in a linear model is quite popular. In the Bayesian context, common prior choices can lead to a posterior expectation of the regression coefficients that is a sparse (or nearly sparse) …