Digital Commons Network^™

Evaluating The Effects Of Pcbs In Non-Alcoholic Fatty Liver Disease & Diabetes And The Role Of Ahr In Regulating The Hepatic Proteome And Lipid Metabolism., Jian Jin

Electronic Theses and Dissertations

Polychlorinated biphenyls (PCBs) are persistent organic pollutants associated with non-alcoholic fatty liver disease (NAFLD) and diabetes. Based on their ability to activate the aryl hydrocarbon receptor (AhR), PCBs are subdivided into two classes: dioxin-like (DL) and non- dioxin-like (NDL) PCBs. This study not only evaluated the chronic effect of DL PCBs (PCB126), NDL PCBs (Aroclor1260 mainly contains NDL), and the DL/NDL PCB mixture (PCB126/Aroclor1260 mixture) on liver, but also explored the acute hepatic effects of DL PCB and potential mechanisms in NAFLD and the role of AhR in regulating hepatic proteome and lipid metabolism, and whether the process independent of …

Kindergarten Readiness And Grade 1 Mathematics Achievement., Faneshia Mcpherson Jones

Electronic Theses and Dissertations

From 2013-2019, all Kentucky school districts have administered a common screener to each student entering kindergarten. In this study, kindergarten readiness—determined by academic skills/cognitive development, language development, and physical development—was a significant predictor of grade 1 end-of-year mathematics achievement. The model predictions show that kindergarten students who met the readiness benchmark had higher grade 1 end-of-year mathematics scores compared to students who entered kindergarten below the readiness benchmark. The model predictions improved substantially with the inclusion of prior level of achievement as indicated by grade 1 beginning of the year mathematics achievement. However, students with stronger readiness skills demonstrated significantly …

Social Media And Fear: Social Media As A Catalyst For Political Fear In The United States., Shane R. White

Electronic Theses and Dissertations

Abstract: Using the American National Election Study data from the 2012 and 2016 surveys I explore how social media usage shapes fear. This is likely caused by the nature of social media leading to oversharing of sensationalized articles likely to elicit an emotional and fearful response. My findings suggest first that social media usage has a statistically significant effect on whether they would say they are afraid of a candidate (2012) and how afraid they say they are of the candidates (2016). Second, social media has little effect on economic fear, and may actually make people more hopeful about the …

Inclusion Of Classified Staff In The Implementation Of Positive Behavior Interventions And Supports: A District Case Study., Devon M. Roberts

Electronic Theses and Dissertations

This qualitative case study examined the current use of Positive Behavior Interventions and Supports (PBIS) within a large school district and how that district includes classified staff within the implementation process. This study utilized information from interviews and focus groups of district leaders, school leaders, and classified staff to evaluate their perspectives on the daily use of PBIS, specifically how classified staff are included in all aspects of the initiative. Using the Normalization Process Theory (NPT) as a theoretical framework, this study sought to make sense of how complex organizational initiatives are intertwined and become embedded into the normal practices …

Development Of A Pediatric Cardiac Assist Maglev Pump For Use With A Universal Driver System., Landon Heath Tompkins

Electronic Theses and Dissertations

Heart failure (HF) remains the leading cause of death, affecting 26 million adults worldwide and 6.5 million adults in the United States. Pediatric HF patients have been a historically underserved population with few options for mechanical circulatory support (MCS) therapy, a leading treatment as an alternative to heart transplantation. To address this clinical need, the Inspired Universal MagLev System is being developed; a low cost, universal magnetically levitated extracorporeal MCS system with interchangeable single-use pumps that will ultimately provide adult and pediatric patients ventricular and respiratory assist therapies. The Inspired Pediatric VAD is the first single-use pump application for this …

The Effects Of Whole Life, Low Dose Cadmium Exposure On High Fat Diet-Induced Nonalcoholic Fatty Liver Disease And The Role Of Zinc., Jamie Lynn Young

Electronic Theses and Dissertations

Nonalcoholic fatty liver disease (NAFLD) is a major global public health concern affecting more than 25% of the world’s population. Although obesity is a major risk factor for NAFLD, it cannot account for many cases, indicating the importance of other factors such as sex and environmental exposures. Cadmium exposure is implicated in the development of NAFLD; however, the influence of early-life, in utero cadmium exposure on the development of diet-induced NAFLD is poorly understood. Therefore, we developed an in vivo, multiple-hit model to study the effect of whole-life, low-dose cadmium exposure on high fat diet (HFD)-induced NAFLD. Additionally, we …

On The Straight And Narrow: How Cultural Beliefs About Sex/Gender Manifest In College Biology Learning Environments., Katherine Ray Kng

Electronic Theses and Dissertations

This dissertation focused on the ways that social beliefs about sex/gender and sexuality manifest in biology classrooms. Especially for health science students, classes include topics like sex, sexuality, sexual behaviors, or sex determination that forms the foundation of their understanding of human forms and behaviors. If the information they receive does not include the LGBTQIA+ community, their education will fail to adequately prepare them for the reality of healthcare practice where they will be expected to treat all patients with dignity and respect. There are three chapters in this dissertation. In chapter one, I asked what beliefs about and conceptions …

Aspects Of Causal Inference., John A. Craycroft

Electronic Theses and Dissertations

Observational studies differ from experimental studies in that assignment of subjects to treatments is not randomized but rather occurs due to natural mechanisms, which are usually hidden from researchers. Yet objectives of the two studies are frequently the same: identify the causal – rather than merely associational – relationship between some treatment or exposure and an outcome. The statistical issues that arise in properly analyzing observational data for this goal are numerous and fascinating, and these issues are encompassed in the domain of causal inference. The research presented in this dissertation explores several distinct aspects of causal inference. This dissertation …

Job Satisfaction For Individuals With Disabilities: Youth One Year Out., Katherine Michelle Cooper Phd

Electronic Theses and Dissertations

Even though there have been decades of research, practice, and legislative efforts in the field of secondary transition, it is believed that students with disabilities are still less likely to enroll in postsecondary education or training, secure competitive employment, and live independently than their nondisabled peers. One of the reasons for this might be the lack of understanding students’ perceptions of employment opportunities. Much of the early vocational legislation focused on the needs of adult workers injured during a war or in civil employment. The last iteration of the Rehabilitation Act in the 1990s described disabilities, even the most significant …

Capacity Building: A Study Of Career Academies And Student Career Self-Efficacy., Shawn Timothy Hinds Jr

Electronic Theses and Dissertations

The phrase “College and Career Readiness” echoes throughout the halls of schools and districts across the United States. Politicians pass legislation aimed at ensuring the readiness of every student graduating from high school. Despite these efforts, the United States is falling further behind in a global race for economic wellbeing and academic preparedness based on one of the most respected global measures of student achievement, the Programme for International Student Assessment (Murphy & Adams, 1998; Tucker, 2016). Even as the social fabric of the country changes and the number of Students of Color and students in poverty increase, there have …

Development Of Core Pharmacy Roles With Competency/Epa Alignment And Levels Of Entrustment., Kimberly K. Daugherty

Electronic Theses and Dissertations

The purpose of this two-phase embedded mixed-method project was to investigate the extent to which a consensus exists among pharmacy professionals regarding core practice-ready roles for graduates that align with current pharmacy competencies/EPA statements with entrustment levels. Current competencies/EPAs were perceived as mapping to the core roles developed during this study, with some missing competencies. Some of the EPA levels of entrustment varied depending on the role to which it was mapped. Some levels were different than the current recommended EPA entrustment level recommended to be used by schools/colleges. The development of a set of core roles with the mapping …

Predicting Dental Student's Performance On National Board Dental Examination (Nbde) Part I: Exploring Demographic Factors, Dental Admission Test (Dat) Factors, Pre-Program Academic Factors, And Dental Program Academic Performance., Wei-Shao Lin

Electronic Theses and Dissertations

Dental students need to successfully challenge a national licensure examination to be able to practice dentistry. Dental educators currently have difficulty in identifying candidates who are at risk of failing this examination. This non-experimental quantitative study examined existing dental student data from the 2017, 2018, and 2019 graduating classes, using a retrospective and correlational approach to identify possible markers for at risk students. Demographic factors, dental admission test (DAT) factors, pre-program academic factors, dental program academic performance, and National Board Dental Examination (NBDE) Part I performance. A series of independent t-tests and One-Way analysis of variances (ANOVAs) were used to …

External Homophobia And Outness In Gay Men., Thomas Charles Isaak Jr

Electronic Theses and Dissertations

Prior studies regarding outness among gay men have often focused on internalized homophobia as a barrier to coming out for gay men, while less emphasis has been placed on external homophobia. Drawing upon social construction theory and Connell’s hierarchy of masculinity, I utilize data from the 2010 Social Justice Sexuality Project to complete an ordinary least square regression to examine the impact of external homophobia on the level of outness among the 987 gay men in this study. In this study, I find that gay men who were exposed to external homophobia reported decreased levels of outness. Further, I find …

Block Periodization Programming: Efficacy In Subjects Of Differing Strength Levels, Paul Moquin

Electronic Theses and Dissertations

Physiological muscle adaptations due to resistance training are still not fully known. The rate and area of hypertrophy could drastically help or hinder athletic performance. The purpose of this study was to observe the changes in lean body mass (and related factors), relative allometrically scaled strength and absolute strength through an 11-week block periodized resistance training program. The subjects (n = 15) realized an increase in total body water (pre = 49.77Kg; post = 51.70Kg), lean body mass (pre = 67.98Kg; post = 70.63Kg), adjusted lean body mass (pre = 20.35Kg; post = 21.03Kg) and cross sectional area (pre = …

Plasma Resuscitation Attenuates Intestinal Barrier Disturbance Following Hemorrhagic Shock., Jessica E. Schucht

Electronic Theses and Dissertations

Background: Intestinal ischemia-reperfusion injury (IIRI) following resuscitated hemorrhagic shock (HS/RES) leads to endothelial damage, microcirculatory dysfunction and intestinal barrier breakdown, increasing intestinal permeability. This pathologic process contributes pathophysiology of multiple organ dysfunction syndrome (MODS) in some trauma patients. Although vascular smooth muscle machinery remains intact, microvascular vasoconstriction occurs secondary to endothelial cell damage, resulting in further ischemia and organ injury. Used separately, resuscitation with Fresh Frozen Plasma (FFP) or Direct Peritoneal Resuscitation (DPR) improves the intestinal microcirculation and alleviates organ injury. Further examination of these effects individually or combined could aid in the resuscitation of hemorrhagic shock. Methods: Sprague Dawley …

"Don't Put An 'Or' Where God Puts An 'And'": Constitutive Rhetoric In Queer Appalachia., Brooke Elizabeth Boling

Electronic Theses and Dissertations

Appalachians who use the word “queer” to specifically refer to being gay, lesbian, bisexual, transgender, queer, intersex, and/or asexual, are regularly faced with negotiating how these parts of their identity can exist simultaneously, as many both within and without the region believe it is impossible to be Appalachian and queer at the same time. Despite rampant homophobia in the region and external narratives suggesting that queer Appalachians do not exist, these folkx have carved out spaces for themselves to assert their identities and create community and belonging through rhetorical actions. Many of these spaces are online, taking place through digital …

Characterization Of Adiposity And Inflammation Genetic Pleiotropy Underlying Cardiovascular Risk Factors In Hispanics., Mohammad Yaser (Anwar)

Electronic Theses and Dissertations

The observed overlap between genetic variants associated with both adiposity and inflammatory markers suggests that changes in both adiposity and inflammation could be partially mediated by common pathways. The pervasive but sparsely characterized “pleiotropic” genetic variants associated with both adiposity and inflammation have been hypothesized to provide insight into the shared biology. This study explored and characterized the genetic pleiotropy underpinning adiposity and inflammation using genetic and phenotypic observations from the Cameron County Hispanic Cohort (CCHC). A total of 3,313 samples and >9 million single nucleotide polymorphisms (SNPs) were examined in this study. Mixed model genome-wide association studies (GWAS) were …

Positive Parenting As A Moderator For Reducing Depression In Inner-City Children Exposed To Contextual Risk Factors? A Longitudinal Multilevel Analysis Of A Family-Based Intervention Program., Donghang Zhang

Electronic Theses and Dissertations

Depression in inner-city children is a serious social problem. Given the existing evidence supporting the links among neighborhood conditions, family functioning, parenting, and child outcome, this study expands the examination of the relationship among contextual factors and child depression from a longitudinal developmental perspective. This study also aims to examine how positive parenting as a protective factor moderates the effect of contextual risk factors on child depression in a sample of low-income, inner-city families. This present study used the secondary data from the Schools and Families Educating (SAFE) Children study (aka SAFE Children Project) with is a longitudinal panel study …

Fostering African American Female Students’ Sense Of Belonging: A Digital Storytelling Participatory Action Research Approach., Rajwinder Kaur

Electronic Theses and Dissertations

This Participatory Action Research dissertation discovers what fosters or diminishes school sense of belonging for African American female students. This is achieved by foregrounding the voices of the individual participants and the collective voice of those within this study. Both Critical Race Theory and Black Feminist Thought guide this dissertation study to ensure the intersectionality between race and gender is addressed. Data for this study was collected during five workshop sessions, where participants created digital stories on their sense of belonging. The findings revealed the importance of students’ racial identity, family, peer relationships, fitting in, safety, and being seen/heard by …

The Many Facets Of Trauma - High Need Index School Principals' Perspectives Of Trauma-Informed Care., Nicole Michelle Fields

Electronic Theses and Dissertations

This qualitative phenomenological study attempts to add to the literature by shedding light on the best practices for fostering and applying effective trauma-informed care (TIC) in schools and the educational practices and policies through human experience elements. Creating trauma-sensitive, safe, and supportive schools requires a new discernment among principals. It also requires holistic changes to transform school, culture, build supporting infrastructure, and alter curriculum content and intervention (McInerney & McKlindon, 2014). TIC refers to treating the whole person mentally, socially, emotionally, and physically. This study interview 14 principals' perspectives in a large urban school district to discover what practices, procedures, …

The Use Of Nanoparticles And Electrospun Fibers For Intravaginal Delivery To Treat Viral And Bacterial Infections And Electrophysiological Measurements Of Synthetic Chloride Channels., Farnaz Minooei

Electronic Theses and Dissertations

Female reproductive viral and bacterial infections affect millions of women worldwide. Given the diversity and magnitude of these unmet reproductive health challenges, topical administration of antiretrovirals (ARVs) and antibiotics have emerged as promising approaches to maintain and restore reproductive health. However, currently available intravaginal dosage forms often suffer from low user adherence and the need for frequent, daily administration to achieve therapeutic effect. To address these challenges, the broad goal of this research was to focus on the development of new localized nanoparticle (NP) and electrospun fiber dosage forms to prolong the delivery and enhance the efficacy of active agents …

Impacts Of Environmental And Hydrologic Factors On Urban Stream Water Quality., Jason Patrik Ingram

Electronic Theses and Dissertations

Urban streams can be impacted by a multitude of hydrologic and environmental factors, making maintaining these water sources difficult. Urbanization can exacerbate these impacts creating new challenges in preserving suitable urban stream water quality. Urbanization is the development of city landscape and suburban living within an otherwise natural region. For this environmental impact study, the effects of city development on urban stream water quality was monitored for Mill Creek in Louisville, Kentucky. To study the effects of urbanization on Mill Creek, this project was completed utilizing the BACI method for comparing impacts. The results of the water quality monitoring were …

Computational Behavioral Analytics: Estimating Psychological Traits In Foreign Languages., Kristopher Wayne Reese

Electronic Theses and Dissertations

The rise of technology proliferating into the workplace has increased the threat of loss of intellectual property, classified, and proprietary information for companies, governments, and academics. This can cause economic damage to the creators of new IP, companies, and whole economies. This technology proliferation has also assisted terror groups and lone wolf actors in pushing their message to a larger audience or finding similar tribal groups that share common, sometimes flawed, beliefs across various social media platforms. These types of challenges have created numerous studies in psycholinguistics, as well as commercial tools, that look to assist in identifying potential threats …

University Budget Models, Institutional Size, And Student Outcomes, James P. Batchelder

Electronic Theses and Dissertations

The purpose of the non-experimental quantitative research study was to identify if there is a significant difference between the types of budget model an institution utilizes, institutional size, and student enrollment, retention, and graduation rates. This study was to identify if there is significant difference between institutional size and the type budget model utilized.

Member institutions of the American Association of State Colleges and Universities (AASCU) were selected to participate in this study due to their similarities of mission and admissions policy. AASCU institutions share a common mission that focuses on access, innovation, regional support, and inclusion. AASCU institutions are …

Assessing Nurse Practitioners' Knowledge And Clinical Practice With Regard To The Oral-Systemic Link, Angela Haynes

Electronic Theses and Dissertations

Nurse Practitioners (NPs) comprise a significant portion of the U.S. primary care workforce and play an essential role in patients' health awareness, prevention strategies, disease management, and in providing appropriate provider referrals. Nurse Practitioners receive education on the oral-systemic connection, yet there have been limited studies on the clinical practice of NPs assessing the oral cavity to evaluate the condition of the teeth and the oral tissues. The purpose of this study was to explore the nurse practitioners’ knowledge and practice habits of assessing the oral cavity for diseases or abnormalities in the mouth that can, in turn, affect overall …

Kind King Or Tyrannical Ruler? An Analysis Of Hilary Mantel’S Henry Viii In Wolf Hall And Bringing Up The Bodies, Amanda S. Nicholson

Electronic Theses and Dissertations

Henry VIII (28 June 1491 – 28 January 1547) served as King of England from 1509 until his death in 1547. A melancholic character, Henry was known for his many marriages, his temper, his bouts of tyranny, and his break with the Catholic Church. Most authors, even those writing contemporary accounts, portray Henry as a villain. Hilary Mantel paints Henry differently. In Wolf Hall and Bringing up the Bodies, the King is as he has always been; argumentative, sardonic, and excessive. However, Mantel chooses to augment these parts of his character with some of his better traits, giving the …

Teacher Perceptions Of Blended Learning To Support 21st Century Learners, Nikki Hensley

Electronic Theses and Dissertations

The purpose of this qualitative study was to understand teacher perceptions of blended learning as an instructional methodology for addressing the needs of diverse learners. The researcher explored the perceptions of teachers who were participating in an ongoing professional development program within their school district. This program focused on improving teaching and learning through the implementation of a blended learning approach. The researcher examined the experiences of teachers as they learned to adapt pedagogical practices to address the learning needs of 21st century students through blended learning. The researcher sought to gain a better understanding of how teachers perceived that …

A Survey Of Pre-Service And In-Service Teachers On Training And Knowledge Of State Anti-Bullying Laws And Policies Related To Students With Disabilities, Molly Henry

Electronic Theses and Dissertations

Bullying is a serious problem on its own but emerging research suggests that bullying may present differently in students with disabilities and affect them more severely than previously thought. The purpose of this study was to explore the multi-layered issue of bullying involving students with disabilities, examine the programs and legislation developed around this issue, and determine the training and knowledge teachers and teacher candidates have regarding the problem. An exploratory survey was completed by 105 teachers and teacher candidates in northeast Tennessee. Descriptive statistics and T-tests revealed that in-service teachers were more knowledgeable in identification of bullying and the …

Best Practices: The Relationship Between School Counselors' Self-Efficacy And Conducting Suicide Risk Assessments, Maisha Roneal Davis

Electronic Theses and Dissertations

The purpose of this quantitative non-experimental cross-sectional study is to investigate the self-efficacy of middle and high school counselors in the state of Louisiana as it relates to their ability to conduct youth suicide risk assessments. Broadly, the study compares the Council for Accreditation of Counseling & Related Educational Programs (CACREP). CACREP accredited and non-accredited school counselors to determine if CACREP accreditation equips school counselors with higher self-efficacy. To this end, the study employs the Counselor Suicide Assessment Efficacy Survey (CSAES) scale to analyze degrees of self-efficacy in conjunction with a demographic survey of sample characteristics associated with educational preparation, …

Pre-Entrance Factors And Student Success In An A.A.S. Nursing Program, Connie Marshall

Electronic Theses and Dissertations

The purpose of this study was to evaluate the relationship of pre-entrance factors and the success of students in an Associate of Applied Science (A.A.S.) degree nursing program at a community college in East Tennessee. The criterion variable was success in the nursing program. Success was defined as academic success in all nursing courses and completion of the nursing program to graduation. The predictor variables of pre-entrance factors were gender, age, Health Education Systems, Incorporated (HESI) A2 scores, Pell Grant eligibility, pre-nursing GPA, and prior licensure. The data for this non-experimental secondary analysis were derived from the electronic database in …